Homo sapiens

18 known processes

MAN2B1

mannosidase, alpha, class 2B, member 1

(Aliases: MANB,LAMAN)

MAN2B1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
carbohydrate metabolic process GO:0005975 207 0.216
Mouse
epithelium development GO:0060429 227 0.214
biological adhesion GO:0022610 331 0.189
multicellular organismal aging GO:0010259 3 0.179
cellular amine metabolic process GO:0044106 41 0.175
cell projection organization GO:0030030 252 0.173
cell development GO:0048468 328 0.154
determination of adult lifespan GO:0008340 2 0.147
positive regulation of cellular amine metabolic process GO:0033240 7 0.138
detection of chemical stimulus involved in sensory perception GO:0050907 33 0.127
cell adhesion GO:0007155 325 0.125
sensory perception of chemical stimulus GO:0007606 38 0.114
regulation of cellular amino acid metabolic process GO:0006521 6 0.108
anatomical structure homeostasis GO:0060249 100 0.105
sensory perception of smell GO:0007608 2 0.104
negative regulation of blood vessel remodeling GO:0060313 1 0.101
purine containing compound catabolic process GO:0072523 411 0.099
amine metabolic process GO:0009308 44 0.096
gtp catabolic process GO:0006184 237 0.096
gtp metabolic process GO:0046039 239 0.095
neurological system process GO:0050877 163 0.095
Mouse
negative regulation of cellular protein metabolic process GO:0032269 353 0.093
response to oxygen containing compound GO:1901700 369 0.091
actin filament based process GO:0030029 224 0.091
immune response GO:0006955 307 0.087
vacuole organization GO:0007033 44 0.084
antigen processing and presentation GO:0019882 33 0.083
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 43 0.079
leukocyte mediated immunity GO:0002443 59 0.075
nervous system development GO:0007399 293 0.074
regulation of cellular amine metabolic process GO:0033238 11 0.072
ribonucleoside triphosphate catabolic process GO:0009203 391 0.071
cell morphogenesis GO:0000902 296 0.069
system process GO:0003008 349 0.068
Mouse
cell activation GO:0001775 213 0.067
cell projection assembly GO:0030031 126 0.066
nucleoside catabolic process GO:0009164 408 0.065
cellular chemical homeostasis GO:0055082 180 0.065
cellular component morphogenesis GO:0032989 314 0.065
maintenance of location GO:0051235 112 0.065
positive regulation of cell proliferation GO:0008284 301 0.062
post embryonic development GO:0009791 2 0.060
regulation of cellular ketone metabolic process GO:0010565 50 0.057
multicellular organismal homeostasis GO:0048871 67 0.057
cellular macromolecular complex assembly GO:0034622 324 0.056
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.056
regulation of establishment of protein localization GO:0070201 242 0.056
defense response GO:0006952 315 0.053
guanosine containing compound metabolic process GO:1901068 244 0.052
regulation of cellular component movement GO:0051270 334 0.052
oxidation reduction process GO:0055114 396 0.050
negative regulation of dendritic cell differentiation GO:2001199 2 0.050
rhythmic behavior GO:0007622 2 0.047
lipid metabolic process GO:0006629 381 0.047
positive regulation of epithelial cell proliferation GO:0050679 65 0.046
rho protein signal transduction GO:0007266 26 0.046
lymphocyte proliferation GO:0046651 70 0.046
locomotory behavior GO:0007626 1 0.046
peptidyl tyrosine phosphorylation GO:0018108 170 0.045
cellular protein complex assembly GO:0043623 188 0.045
cellular amino acid metabolic process GO:0006520 116 0.045
purine nucleotide catabolic process GO:0006195 405 0.045
small gtpase mediated signal transduction GO:0007264 78 0.044
regulation of defense response GO:0031347 154 0.043
ribonucleoside catabolic process GO:0042454 406 0.043
positive regulation of hydrolase activity GO:0051345 331 0.042
signal transduction by phosphorylation GO:0023014 297 0.042
regulation of nucleoside metabolic process GO:0009118 209 0.042
cytokine production GO:0001816 247 0.042
negative regulation of insulin secretion involved in cellular response to glucose stimulus GO:0061179 1 0.042
negative regulation of cell death GO:0060548 345 0.041
regulation of nucleotide metabolic process GO:0006140 269 0.041
cdc42 protein signal transduction GO:0032488 4 0.041
sensory perception of bitter taste GO:0050913 28 0.040
glycosyl compound catabolic process GO:1901658 413 0.040
membrane organization GO:0061024 292 0.040
negative regulation of phosphate metabolic process GO:0045936 267 0.040
actin cytoskeleton organization GO:0030036 207 0.040
positive regulation of immune system process GO:0002684 283 0.040
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.039
regulation of cell differentiation GO:0045595 393 0.039
guanosine containing compound catabolic process GO:1901069 239 0.039
regulation of gtp catabolic process GO:0033124 180 0.039
negative regulation of catalytic activity GO:0043086 335 0.039
negative regulation of multicellular organismal process GO:0051241 317 0.039
innate immune response GO:0045087 178 0.039
organophosphate catabolic process GO:0046434 430 0.039
positive regulation of locomotion GO:0040017 186 0.038
negative regulation of hydrolase activity GO:0051346 182 0.038
nucleoside phosphate catabolic process GO:1901292 412 0.038
cellular ketone metabolic process GO:0042180 80 0.037
nucleotide catabolic process GO:0009166 408 0.037
regulation of purine nucleotide metabolic process GO:1900542 264 0.037
positive regulation of gtp catabolic process GO:0033126 166 0.037
cellular macromolecule catabolic process GO:0044265 380 0.036
sex determination GO:0007530 3 0.036
chemotaxis GO:0006935 157 0.036
regulation of cytoskeleton organization GO:0051493 177 0.035
lytic vacuole organization GO:0080171 24 0.035
regulation of actin filament based process GO:0032970 141 0.035
regulation of lymphocyte activation GO:0051249 103 0.034
regulation of epithelial cell proliferation GO:0050678 113 0.034
elastin catabolic process GO:0060309 1 0.034
positive regulation of nucleoside metabolic process GO:0045979 186 0.034
regulation of actin cytoskeleton organization GO:0032956 116 0.033
positive regulation of rho gtpase activity GO:0032321 56 0.033
negative regulation of cell differentiation GO:0045596 171 0.033
chemical homeostasis GO:0048878 306 0.033
regeneration GO:0031099 4 0.033
carbohydrate catabolic process GO:0016052 36 0.033
regulation of vesicle mediated transport GO:0060627 130 0.032
negative regulation of cellular component organization GO:0051129 235 0.032
actin filament organization GO:0007015 128 0.032
regulation of protein localization GO:0032880 296 0.032
positive regulation of protein phosphorylation GO:0001934 313 0.032
negative regulation of phosphorus metabolic process GO:0010563 267 0.031
regulation of mononuclear cell proliferation GO:0032944 65 0.031
response to wounding GO:0009611 168 0.031
cellular carbohydrate metabolic process GO:0044262 84 0.031
collagen catabolic process GO:0030574 10 0.030
nucleoside triphosphate metabolic process GO:0009141 422 0.030
vesicle mediated transport GO:0016192 371 0.030
actin polymerization or depolymerization GO:0008154 56 0.030
regulation of nucleotide catabolic process GO:0030811 205 0.030
t cell proliferation GO:0042098 45 0.030
ribonucleoside triphosphate metabolic process GO:0009199 412 0.030
lipid catabolic process GO:0016042 84 0.030
taxis GO:0042330 157 0.030
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.030
segmentation GO:0035282 4 0.029
sensory perception GO:0007600 103 0.029
regulation of cell motility GO:2000145 299 0.029
neuron projection development GO:0031175 106 0.028
regulation of immune response GO:0050776 201 0.028
gland development GO:0048732 48 0.028
maintenance of location in cell GO:0051651 62 0.028
cellular homeostasis GO:0019725 196 0.028
cell morphogenesis involved in differentiation GO:0000904 144 0.028
circulatory system development GO:0072359 262 0.027
positive regulation of cell motility GO:2000147 177 0.027
neuron differentiation GO:0030182 138 0.027
immune effector process GO:0002252 159 0.027
cellular lipid metabolic process GO:0044255 303 0.027
regulation of cell adhesion GO:0030155 166 0.027
regulation of cytokine production GO:0001817 232 0.027
regulation of cell activation GO:0050865 125 0.026
positive regulation of cellular component organization GO:0051130 376 0.026
response to abiotic stimulus GO:0009628 336 0.026
ribonucleotide catabolic process GO:0009261 405 0.026
regulation of cellular response to stress GO:0080135 244 0.026
regulation of innate immune response GO:0045088 97 0.026
negative regulation of cellular catabolic process GO:0031330 83 0.025
neurogenesis GO:0022008 169 0.025
purine ribonucleotide catabolic process GO:0009154 404 0.025
vasculature development GO:0001944 181 0.025
positive regulation of ras gtpase activity GO:0032320 117 0.025
negative regulation of developmental process GO:0051093 247 0.025
cardiovascular system development GO:0072358 262 0.025
mononuclear cell proliferation GO:0032943 71 0.025
small molecule biosynthetic process GO:0044283 157 0.025
neuromuscular process GO:0050905 15 0.025
cell substrate adhesion GO:0031589 132 0.025
intracellular protein transport GO:0006886 270 0.025
response to oxidative stress GO:0006979 121 0.025
peptide catabolic process GO:0043171 10 0.025
ameboidal type cell migration GO:0001667 135 0.025
regulation of anatomical structure morphogenesis GO:0022603 286 0.024
cellular amide metabolic process GO:0043603 69 0.024
positive regulation of cellular catabolic process GO:0031331 284 0.024
generation of neurons GO:0048699 152 0.024
regulation of cell projection organization GO:0031344 107 0.024
epithelial cell proliferation GO:0050673 128 0.024
regulation of collagen catabolic process GO:0010710 3 0.024
cellular response to oxygen containing compound GO:1901701 276 0.024
cell part morphogenesis GO:0032990 137 0.024
cell projection morphogenesis GO:0048858 129 0.024
leukocyte activation GO:0045321 164 0.024
proteasomal protein catabolic process GO:0010498 176 0.024
blastoderm segmentation GO:0007350 2 0.023
purine ribonucleoside catabolic process GO:0046130 398 0.023
inflammatory response GO:0006954 79 0.023
purine ribonucleoside metabolic process GO:0046128 437 0.023
regulation of rho gtpase activity GO:0032319 66 0.023
antigen processing and presentation of peptide antigen GO:0048002 18 0.023
lipid localization GO:0010876 106 0.023
purine nucleoside triphosphate metabolic process GO:0009144 412 0.023
response to hormone GO:0009725 175 0.022
protein catabolic process GO:0030163 325 0.022
regulation of protein maturation GO:1903317 150 0.022
regulation of cell morphogenesis GO:0022604 153 0.022
single organism membrane organization GO:0044802 268 0.022
negative regulation of cell proliferation GO:0008285 228 0.022
response to organonitrogen compound GO:0010243 156 0.022
purine nucleoside triphosphate catabolic process GO:0009146 392 0.022
regulation of purine nucleotide catabolic process GO:0033121 205 0.022
muscle cell cellular homeostasis GO:0046716 3 0.022
peptidyl tyrosine modification GO:0018212 170 0.022
regulation of systemic arterial blood pressure by circulatory renin angiotensin GO:0001991 4 0.022
regulation of locomotion GO:0040012 329 0.021
positive regulation of mapk cascade GO:0043410 190 0.021
single organism carbohydrate metabolic process GO:0044723 193 0.021
Mouse
response to nitrogen compound GO:1901698 184 0.021
epithelial cell differentiation GO:0030855 141 0.021
regulation of cellular component biogenesis GO:0044087 281 0.021
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.021
cell chemotaxis GO:0060326 112 0.021
negative regulation of programmed cell death GO:0043069 321 0.021
regulation of mapk cascade GO:0043408 262 0.020
regulation of immune effector process GO:0002697 91 0.020
response to bacterium GO:0009617 144 0.020
positive regulation of cytokine production GO:0001819 167 0.020
regulation of protein complex assembly GO:0043254 147 0.020
cell growth GO:0016049 160 0.020
negative regulation of leukocyte activation GO:0002695 26 0.020
neuron development GO:0048666 113 0.020
protein localization to organelle GO:0033365 280 0.020
positive regulation of gtpase activity GO:0043547 166 0.020
hematopoietic or lymphoid organ development GO:0048534 186 0.020
response to biotic stimulus GO:0009607 276 0.020
immune system development GO:0002520 195 0.020
posttranscriptional regulation of gene expression GO:0010608 213 0.019
cellular response to endogenous stimulus GO:0071495 336 0.019
negative regulation of elastin catabolic process GO:0060311 1 0.019
response to external biotic stimulus GO:0043207 261 0.019
regulation of elastin catabolic process GO:0060310 1 0.019
regulation of lipid metabolic process GO:0019216 96 0.019
regulation of leukocyte proliferation GO:0070663 67 0.019
regulation of leukocyte activation GO:0002694 115 0.019
ras protein signal transduction GO:0007265 73 0.019
lipid biosynthetic process GO:0008610 177 0.019
regulation of cell migration GO:0030334 289 0.019
hemopoiesis GO:0030097 180 0.019
detection of chemical stimulus GO:0009593 55 0.019
detection of stimulus GO:0051606 85 0.018
nucleoside triphosphate catabolic process GO:0009143 394 0.018
actin filament bundle organization GO:0061572 54 0.018
response to radiation GO:0009314 151 0.018
cellular protein catabolic process GO:0044257 261 0.018
positive regulation of defense response GO:0031349 87 0.018
cellular response to growth factor stimulus GO:0071363 197 0.018
regulation of protein transport GO:0051223 213 0.018
mapk cascade GO:0000165 288 0.018
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.018
dephosphorylation GO:0016311 209 0.018
positive regulation of regulatory t cell differentiation GO:0045591 3 0.018
aging GO:0007568 66 0.017
response to other organism GO:0051707 261 0.017
negative regulation of immune system process GO:0002683 136 0.017
circadian behavior GO:0048512 2 0.017
positive regulation of nucleotide catabolic process GO:0030813 185 0.017
membrane lipid metabolic process GO:0006643 53 0.017
negative regulation of protein phosphorylation GO:0001933 140 0.017
positive regulation of developmental process GO:0051094 314 0.017
protein localization to membrane GO:0072657 160 0.017
regulation of cell shape GO:0008360 48 0.017
growth GO:0040007 202 0.016
regulation of kinase activity GO:0043549 314 0.016
regulation of secretion GO:0051046 194 0.016
negative regulation of catabolic process GO:0009895 104 0.016
regulation of ras protein signal transduction GO:0046578 155 0.016
lipid transport GO:0006869 90 0.016
positive regulation of cell migration GO:0030335 172 0.016
multicellular organismal macromolecule metabolic process GO:0044259 29 0.016
prostate gland development GO:0030850 3 0.016
positive regulation of transferase activity GO:0051347 227 0.016
positive regulation of cell activation GO:0050867 81 0.016
protein modification by small protein conjugation GO:0032446 342 0.016
organic hydroxy compound metabolic process GO:1901615 147 0.016
positive regulation of cellular component movement GO:0051272 181 0.016
regulation of erk1 and erk2 cascade GO:0070372 99 0.016
protein processing GO:0016485 226 0.016
leukocyte proliferation GO:0070661 74 0.016
regulation of lymphocyte proliferation GO:0050670 64 0.016
regulation of gtpase activity GO:0043087 180 0.016
protein polymerization GO:0051258 71 0.016
reproductive process GO:0022414 106 0.015
neuromuscular junction development GO:0007528 3 0.015
regulation of protein kinase activity GO:0045859 289 0.015
negative regulation of organelle organization GO:0010639 126 0.015
negative regulation of cellular amine metabolic process GO:0033239 3 0.015
protein maturation GO:0051604 233 0.015
negative regulation of collagen catabolic process GO:0010711 1 0.015
negative regulation of cell migration GO:0030336 102 0.015
alcohol metabolic process GO:0006066 114 0.015
epithelial cell migration GO:0010631 119 0.015
detection of stimulus involved in sensory perception GO:0050906 43 0.015
negative regulation of cell activation GO:0050866 33 0.015
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 40 0.015
central nervous system development GO:0007417 123 0.015
positive regulation of cytoskeleton organization GO:0051495 83 0.015
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.015
somatic muscle development GO:0007525 1 0.014
negative regulation of protein metabolic process GO:0051248 391 0.014
blood circulation GO:0008015 113 0.014
multicellular organismal metabolic process GO:0044236 34 0.014
modification dependent macromolecule catabolic process GO:0043632 212 0.014
neuron projection regeneration GO:0031102 1 0.014
regulation of blood vessel remodeling GO:0060312 2 0.014
memory GO:0007613 3 0.014
positive regulation of catabolic process GO:0009896 310 0.014
negative regulation of intracellular signal transduction GO:1902532 183 0.014
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.014
regulation of intracellular protein transport GO:0033157 123 0.014
regulation of protein polymerization GO:0032271 63 0.014
cellular lipid catabolic process GO:0044242 65 0.014
regulation of rho protein signal transduction GO:0035023 79 0.014
positive regulation of cellular component biogenesis GO:0044089 158 0.014
positive regulation of immune response GO:0050778 159 0.014
response to cytokine GO:0034097 232 0.014
wound healing GO:0042060 115 0.014
embryo development GO:0009790 123 0.014
lymphocyte mediated immunity GO:0002449 48 0.014
response to growth factor GO:0070848 205 0.014
response to salt stress GO:0009651 3 0.014
glycerophospholipid metabolic process GO:0006650 84 0.014
respiratory gaseous exchange GO:0007585 3 0.014
membrane protein proteolysis GO:0033619 38 0.014
respiratory system process GO:0003016 3 0.013
adult locomotory behavior GO:0008344 1 0.013
regulation of transferase activity GO:0051338 355 0.013
ethanolamine containing compound metabolic process GO:0042439 26 0.013
cytoplasmic transport GO:0016482 379 0.013
positive regulation of kinase activity GO:0033674 204 0.013
post embryonic organ development GO:0048569 1 0.013
single organism reproductive process GO:0044702 98 0.013
g protein coupled receptor signaling pathway GO:0007186 207 0.013
negative regulation of apoptotic process GO:0043066 316 0.013
negative regulation of cytoskeleton organization GO:0051494 45 0.013
secretion by cell GO:0032940 226 0.013
anatomical structure formation involved in morphogenesis GO:0048646 284 0.013
single organism carbohydrate catabolic process GO:0044724 33 0.013
positive regulation of transport GO:0051050 336 0.013
female gamete generation GO:0007292 2 0.013
negative regulation of actin nucleation GO:0051126 3 0.013
negative regulation of protein modification process GO:0031400 200 0.013
positive regulation of protein kinase activity GO:0045860 190 0.013
cell morphogenesis involved in neuron differentiation GO:0048667 44 0.013
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.013
response to alcohol GO:0097305 64 0.013
positive regulation of cell projection organization GO:0031346 64 0.012
negative regulation of transferase activity GO:0051348 124 0.012
ossification GO:0001503 121 0.012
jak stat cascade GO:0007259 46 0.012
retina homeostasis GO:0001895 42 0.012
regulation of cell projection assembly GO:0060491 47 0.012
glycerolipid metabolic process GO:0046486 107 0.012
regulation of leukocyte migration GO:0002685 63 0.012
muscle contraction GO:0006936 73 0.012
single organism cell adhesion GO:0098602 179 0.012
positive regulation of phosphorylation GO:0042327 394 0.012
divalent inorganic cation homeostasis GO:0072507 136 0.012
regulation of system process GO:0044057 101 0.012
chromatin modification GO:0016568 298 0.012
regulation of vasculature development GO:1901342 97 0.012
endocytosis GO:0006897 159 0.012
regulation of protein stability GO:0031647 87 0.012
tissue homeostasis GO:0001894 63 0.012
cellular response to abiotic stimulus GO:0071214 117 0.012
enzyme linked receptor protein signaling pathway GO:0007167 303 0.011
regulation of adaptive immune response GO:0002819 33 0.011
circadian sleep wake cycle process GO:0022410 2 0.011
behavior GO:0007610 112 0.011
Mouse
regulation of response to external stimulus GO:0032101 222 0.011
neuromuscular process controlling posture GO:0050884 2 0.011
lymphocyte activation GO:0046649 133 0.011
renal system development GO:0072001 63 0.011
head development GO:0060322 108 0.011
epithelial cell development GO:0002064 34 0.011
purine nucleoside catabolic process GO:0006152 398 0.011
nuclear transport GO:0051169 179 0.011
response to fungus GO:0009620 4 0.011
response to oxygen levels GO:0070482 100 0.011
single organism cellular localization GO:1902580 332 0.011
positive regulation of leukocyte activation GO:0002696 80 0.011
tripartite regional subdivision GO:0007351 2 0.011
cellular response to oxidative stress GO:0034599 85 0.011
organelle assembly GO:0070925 176 0.011
carbohydrate derivative biosynthetic process GO:1901137 207 0.011
oogenesis GO:0048477 2 0.011
defense response to gram positive bacterium GO:0050830 29 0.011
negative regulation of phosphorylation GO:0042326 174 0.011
transition metal ion transport GO:0000041 23 0.011
heart contraction GO:0060047 62 0.011
nucleoside monophosphate metabolic process GO:0009123 191 0.011
metencephalon development GO:0022037 2 0.011
response to axon injury GO:0048678 1 0.011
establishment of protein localization to organelle GO:0072594 172 0.011
epithelium migration GO:0090132 119 0.010
negative regulation of cell motility GO:2000146 104 0.010
regulation of homeostatic process GO:0032844 121 0.010
cellular response to extracellular stimulus GO:0031668 72 0.010
regulation of small gtpase mediated signal transduction GO:0051056 156 0.010
cellular response to lipid GO:0071396 127 0.010
endosomal transport GO:0016197 129 0.010
regulation of cell division GO:0051302 116 0.010
tube closure GO:0060606 3 0.010
purine nucleoside monophosphate catabolic process GO:0009128 158 0.010
organophosphate biosynthetic process GO:0090407 163 0.010

MAN2B1 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.832
inherited metabolic disorder DOID:655 242 0.832
lipid storage disease DOID:9455 28 0.376
lysosomal storage disease DOID:3211 47 0.376
central nervous system disease DOID:331 186 0.244
nervous system disease DOID:863 431 0.244
glycogen storage disease DOID:2747 10 0.091
carbohydrate metabolic disorder DOID:2978 55 0.091
glycogen metabolism disorder DOID:0050728 10 0.091
immune system disease DOID:2914 155 0.066
neurodegenerative disease DOID:1289 102 0.042
musculoskeletal system disease DOID:17 223 0.030
connective tissue disease DOID:65 109 0.030
sensory system disease DOID:0050155 203 0.023
eye and adnexa disease DOID:1492 150 0.023
eye disease DOID:5614 149 0.023
neuronal ceroid lipofuscinosis DOID:14503 11 0.023
cerebral degeneration DOID:1443 16 0.021
brain disease DOID:936 73 0.021
bone remodeling disease DOID:0080005 26 0.021
bone disease DOID:0080001 88 0.021
osteopetrosis DOID:13533 9 0.021
osteosclerosis DOID:4254 16 0.021
leukodystrophy DOID:10579 8 0.013
sphingolipidosis DOID:1927 14 0.012