|
|
histone modification
|
GO:0016570 |
251 |
0.989
|
|
|
|
chromatin modification
|
GO:0016568 |
298 |
0.988
|
|
|
|
covalent chromatin modification
|
GO:0016569 |
254 |
0.973
|
|
|
|
chromatin organization
|
GO:0006325 |
351 |
0.950
|
|
|
|
protein acetylation
|
GO:0006473 |
116 |
0.897
|
|
|
|
peptidyl lysine modification
|
GO:0018205 |
144 |
0.852
|
|
|
|
protein acylation
|
GO:0043543 |
138 |
0.785
|
|
|
|
histone h3 acetylation
|
GO:0043966 |
45 |
0.602
|
Human |
|
|
peptidyl lysine dimethylation
|
GO:0018027 |
3 |
0.596
|
|
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
379 |
0.572
|
Human Fly |
|
|
histone h4 k8 acetylation
|
GO:0043982 |
15 |
0.533
|
|
|
|
internal peptidyl lysine acetylation
|
GO:0018393 |
97 |
0.488
|
|
|
|
protein ubiquitination
|
GO:0016567 |
314 |
0.435
|
|
|
|
peptidyl lysine methylation
|
GO:0018022 |
37 |
0.432
|
|
|
|
histone h4 acetylation
|
GO:0043967 |
47 |
0.410
|
|
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.365
|
|
|
|
peptidyl lysine acetylation
|
GO:0018394 |
101 |
0.347
|
|
|
|
internal protein amino acid acetylation
|
GO:0006475 |
101 |
0.343
|
|
|
|
modification dependent macromolecule catabolic process
|
GO:0043632 |
212 |
0.322
|
Human |
|
|
regulation of gene expression epigenetic
|
GO:0040029 |
73 |
0.297
|
Fly |
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.270
|
|
|
|
protein modification by small protein conjugation
|
GO:0032446 |
342 |
0.265
|
|
|
|
protein processing
|
GO:0016485 |
226 |
0.261
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.226
|
|
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
391 |
0.223
|
|
|
|
regulation of cellular response to stress
|
GO:0080135 |
244 |
0.214
|
Fly |
|
|
histone h4 k5 acetylation
|
GO:0043981 |
15 |
0.204
|
|
|
|
histone methylation
|
GO:0016571 |
60 |
0.204
|
|
|
|
regulation of proteolysis
|
GO:0030162 |
293 |
0.198
|
|
|
|
histone lysine methylation
|
GO:0034968 |
50 |
0.182
|
|
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.181
|
|
|
|
ubiquitin dependent protein catabolic process
|
GO:0006511 |
206 |
0.176
|
Human |
|
|
modification dependent protein catabolic process
|
GO:0019941 |
209 |
0.168
|
Human |
|
|
dna repair
|
GO:0006281 |
198 |
0.164
|
Human Fly |
|
|
apoptotic signaling pathway
|
GO:0097190 |
268 |
0.159
|
|
|
|
hematopoietic or lymphoid organ development
|
GO:0048534 |
186 |
0.156
|
|
|
|
histone h4 k16 acetylation
|
GO:0043984 |
14 |
0.147
|
|
|
|
regulation of cell cycle
|
GO:0051726 |
393 |
0.145
|
|
|
|
response to abiotic stimulus
|
GO:0009628 |
336 |
0.142
|
Human Fly |
|
|
protein alkylation
|
GO:0008213 |
74 |
0.134
|
|
|
|
regulation of cell division
|
GO:0051302 |
116 |
0.131
|
|
|
|
chromosome segregation
|
GO:0007059 |
114 |
0.129
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.127
|
|
|
|
histone acetylation
|
GO:0016573 |
93 |
0.126
|
|
|
|
regulation of proteasomal protein catabolic process
|
GO:0061136 |
87 |
0.124
|
|
|
|
mitotic cell cycle
|
GO:0000278 |
326 |
0.123
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
41 |
0.123
|
|
|
|
negative regulation of cell cycle process
|
GO:0010948 |
121 |
0.122
|
|
|
|
immune system development
|
GO:0002520 |
195 |
0.121
|
|
|
|
epidermis morphogenesis
|
GO:0048730 |
3 |
0.120
|
|
|
|
protein maturation
|
GO:0051604 |
233 |
0.113
|
|
|
|
protein catabolic process
|
GO:0030163 |
325 |
0.109
|
Human |
|
|
cell development
|
GO:0048468 |
328 |
0.108
|
|
|
|
negative regulation of protein processing
|
GO:0010955 |
142 |
0.104
|
|
|
|
regulation of protein processing
|
GO:0070613 |
150 |
0.100
|
|
|
|
multicellular organismal aging
|
GO:0010259 |
3 |
0.100
|
|
|
|
proteasome mediated ubiquitin dependent protein catabolic process
|
GO:0043161 |
156 |
0.099
|
Human |
|
|
telomere maintenance
|
GO:0000723 |
32 |
0.098
|
|
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
211 |
0.097
|
Fly |
|
|
response to radiation
|
GO:0009314 |
151 |
0.096
|
Human Fly |
|
|
macromolecule methylation
|
GO:0043414 |
97 |
0.095
|
|
|
|
regulation of proteolysis involved in cellular protein catabolic process
|
GO:1903050 |
91 |
0.095
|
|
|
|
regulation of cell cycle process
|
GO:0010564 |
266 |
0.093
|
|
|
|
female gamete generation
|
GO:0007292 |
2 |
0.092
|
|
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
380 |
0.091
|
Human |
|
|
response to lipid
|
GO:0033993 |
206 |
0.090
|
Human |
|
|
negative regulation of cell proliferation
|
GO:0008285 |
228 |
0.090
|
|
|
|
neuroblast proliferation
|
GO:0007405 |
4 |
0.090
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
80 |
0.089
|
|
|
|
cell cycle checkpoint
|
GO:0000075 |
117 |
0.087
|
Fly |
|
|
oogenesis
|
GO:0048477 |
2 |
0.087
|
|
|
|
negative regulation of cellular component organization
|
GO:0051129 |
235 |
0.087
|
|
|
|
positive regulation of catabolic process
|
GO:0009896 |
310 |
0.086
|
|
|
|
oocyte differentiation
|
GO:0009994 |
2 |
0.085
|
|
|
|
negative regulation of cell cycle
|
GO:0045786 |
193 |
0.085
|
|
|
|
regulation of protein ubiquitination
|
GO:0031396 |
95 |
0.084
|
|
|
|
mitotic nuclear division
|
GO:0007067 |
119 |
0.082
|
|
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.081
|
|
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.080
|
|
|
|
cellular component morphogenesis
|
GO:0032989 |
314 |
0.080
|
|
|
|
regulation of wnt signaling pathway
|
GO:0030111 |
123 |
0.079
|
|
|
|
negative regulation of protein maturation
|
GO:1903318 |
142 |
0.079
|
|
|
|
regulation of response to dna damage stimulus
|
GO:2001020 |
94 |
0.078
|
Fly |
|
|
regulation of proteasomal ubiquitin dependent protein catabolic process
|
GO:0032434 |
71 |
0.078
|
|
|
|
response to ionizing radiation
|
GO:0010212 |
65 |
0.078
|
Human Fly |
|
|
regulation of cell differentiation
|
GO:0045595 |
393 |
0.077
|
|
|
|
determination of adult lifespan
|
GO:0008340 |
2 |
0.075
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
6 |
0.075
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
7 |
0.072
|
|
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.072
|
Fly |
|
|
cellular lipid metabolic process
|
GO:0044255 |
303 |
0.071
|
|
|
|
cellular protein catabolic process
|
GO:0044257 |
261 |
0.071
|
Human |
|
|
regulation of protein maturation
|
GO:1903317 |
150 |
0.071
|
|
|
|
negative regulation of proteolysis
|
GO:0045861 |
132 |
0.070
|
|
|
|
cell division
|
GO:0051301 |
168 |
0.070
|
|
|
|
regulation of transforming growth factor beta receptor signaling pathway
|
GO:0017015 |
48 |
0.068
|
|
|
|
organelle fission
|
GO:0048285 |
149 |
0.068
|
|
|
|
positive regulation of transport
|
GO:0051050 |
336 |
0.068
|
|
|
|
gene silencing
|
GO:0016458 |
49 |
0.068
|
|
|
|
regulation of protein catabolic process
|
GO:0042176 |
155 |
0.068
|
|
|
|
protein methylation
|
GO:0006479 |
74 |
0.067
|
|
|
|
regulation of mitosis
|
GO:0007088 |
63 |
0.067
|
|
|
|
regulation of chromosome organization
|
GO:0033044 |
103 |
0.066
|
Fly |
|
|
methylation
|
GO:0032259 |
106 |
0.066
|
|
|
|
response to growth factor
|
GO:0070848 |
205 |
0.063
|
|
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.062
|
Fly |
|
|
regulation of endopeptidase activity
|
GO:0052548 |
170 |
0.062
|
|
|
|
negative regulation of chromosome organization
|
GO:2001251 |
48 |
0.061
|
|
|
|
regulation of mitotic metaphase anaphase transition
|
GO:0030071 |
26 |
0.060
|
|
|
|
lipid metabolic process
|
GO:0006629 |
381 |
0.060
|
|
|
|
negative regulation of programmed cell death
|
GO:0043069 |
321 |
0.059
|
Fly |
|
|
positive regulation of organelle organization
|
GO:0010638 |
195 |
0.058
|
|
|
|
regulation of cysteine type endopeptidase activity
|
GO:2000116 |
127 |
0.057
|
|
|
|
regulation of protein modification by small protein conjugation or removal
|
GO:1903320 |
107 |
0.057
|
|
|
|
regulation of cellular protein catabolic process
|
GO:1903362 |
96 |
0.056
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.055
|
|
|
|
purine nucleoside catabolic process
|
GO:0006152 |
398 |
0.055
|
|
|
|
nucleoside phosphate catabolic process
|
GO:1901292 |
412 |
0.055
|
|
|
|
regulation of transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0090092 |
90 |
0.055
|
|
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
244 |
0.055
|
Human |
|
|
negative regulation of protein modification process
|
GO:0031400 |
200 |
0.054
|
|
|
|
chromatin silencing
|
GO:0006342 |
12 |
0.054
|
|
|
|
taxis
|
GO:0042330 |
157 |
0.053
|
|
|
|
regulation of cell growth
|
GO:0001558 |
135 |
0.053
|
|
|
|
purine ribonucleoside triphosphate catabolic process
|
GO:0009207 |
391 |
0.053
|
|
|
|
erythrocyte development
|
GO:0048821 |
3 |
0.053
|
|
|
|
negative regulation of transcription from rna polymerase ii promoter
|
GO:0000122 |
281 |
0.052
|
Human |
|
|
oocyte development
|
GO:0048599 |
1 |
0.052
|
|
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
127 |
0.052
|
|
|
|
signal transduction in response to dna damage
|
GO:0042770 |
57 |
0.052
|
Human Fly |
|
|
negative regulation of mitotic cell cycle phase transition
|
GO:1901991 |
85 |
0.051
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
11 |
0.050
|
|
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.050
|
|
|
|
lipid biosynthetic process
|
GO:0008610 |
177 |
0.050
|
|
|
|
anatomical structure formation involved in morphogenesis
|
GO:0048646 |
284 |
0.049
|
|
|
|
ribonucleoside triphosphate catabolic process
|
GO:0009203 |
391 |
0.049
|
|
|
|
ribonucleoside triphosphate metabolic process
|
GO:0009199 |
412 |
0.049
|
|
|
|
histone h3 k4 methylation
|
GO:0051568 |
27 |
0.048
|
|
|
|
post embryonic development
|
GO:0009791 |
2 |
0.048
|
|
|
|
anatomical structure homeostasis
|
GO:0060249 |
100 |
0.048
|
|
|
|
regulation of cellular ketone metabolic process by positive regulation of transcription from rna polymerase ii promoter
|
GO:0072366 |
1 |
0.048
|
|
|
|
nucleoside triphosphate metabolic process
|
GO:0009141 |
422 |
0.047
|
|
|
|
purine nucleoside triphosphate catabolic process
|
GO:0009146 |
392 |
0.047
|
|
|
|
negative regulation of cell cycle phase transition
|
GO:1901988 |
89 |
0.045
|
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
249 |
0.045
|
|
|
|
response to uv
|
GO:0009411 |
73 |
0.045
|
|
|
|
chromosome separation
|
GO:0051304 |
23 |
0.045
|
|
|
|
transdifferentiation
|
GO:0060290 |
2 |
0.045
|
|
|
|
purine containing compound catabolic process
|
GO:0072523 |
411 |
0.045
|
|
|
|
regulation of metaphase anaphase transition of cell cycle
|
GO:1902099 |
26 |
0.045
|
|
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
411 |
0.045
|
|
|
|
regulation of protein acetylation
|
GO:1901983 |
25 |
0.044
|
Fly |
|
|
protein deacylation
|
GO:0035601 |
39 |
0.044
|
|
|
|
ribonucleoside catabolic process
|
GO:0042454 |
406 |
0.044
|
|
|
|
positive regulation of transferase activity
|
GO:0051347 |
227 |
0.044
|
|
|
|
embryonic hemopoiesis
|
GO:0035162 |
4 |
0.044
|
|
|
|
nucleoside triphosphate catabolic process
|
GO:0009143 |
394 |
0.044
|
|
|
|
nervous system development
|
GO:0007399 |
293 |
0.043
|
|
|
|
positive regulation of cellular catabolic process
|
GO:0031331 |
284 |
0.043
|
|
|
|
cellular response to endogenous stimulus
|
GO:0071495 |
336 |
0.043
|
Human |
|
|
regulation of growth
|
GO:0040008 |
165 |
0.043
|
|
|
|
proteasomal protein catabolic process
|
GO:0010498 |
176 |
0.043
|
Human |
|
|
response to caffeine
|
GO:0031000 |
3 |
0.043
|
|
|
|
cell cycle phase transition
|
GO:0044770 |
173 |
0.042
|
|
|
|
regulation of hormone levels
|
GO:0010817 |
125 |
0.042
|
|
|
|
mitotic cell cycle checkpoint
|
GO:0007093 |
68 |
0.042
|
|
|
|
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process
|
GO:0031145 |
25 |
0.042
|
|
|
|
locomotory behavior
|
GO:0007626 |
1 |
0.042
|
|
|
|
positive regulation of protein modification by small protein conjugation or removal
|
GO:1903322 |
61 |
0.041
|
|
|
|
regulation of mitotic cell cycle
|
GO:0007346 |
189 |
0.041
|
|
|
|
secretion
|
GO:0046903 |
254 |
0.041
|
|
|
|
cell projection organization
|
GO:0030030 |
252 |
0.041
|
|
|
|
nuclear division
|
GO:0000280 |
128 |
0.040
|
|
|
|
mitotic sister chromatid segregation
|
GO:0000070 |
53 |
0.040
|
|
|
|
signal transduction by p53 class mediator
|
GO:0072331 |
72 |
0.040
|
Human Fly |
|
|
purine ribonucleoside metabolic process
|
GO:0046128 |
437 |
0.040
|
|
|
|
posttranscriptional regulation of gene expression
|
GO:0010608 |
213 |
0.040
|
|
|
|
negative regulation of mitotic sister chromatid separation
|
GO:2000816 |
17 |
0.039
|
|
|
|
enzyme linked receptor protein signaling pathway
|
GO:0007167 |
303 |
0.039
|
|
|
|
guanosine containing compound catabolic process
|
GO:1901069 |
239 |
0.039
|
|
|
|
cation transport
|
GO:0006812 |
331 |
0.039
|
|
|
|
central nervous system development
|
GO:0007417 |
123 |
0.039
|
|
|
|
regulation of nuclear division
|
GO:0051783 |
65 |
0.038
|
|
|
|
chemotaxis
|
GO:0006935 |
157 |
0.038
|
|
|
|
histone h3 k4 trimethylation
|
GO:0080182 |
7 |
0.038
|
|
|
|
negative regulation of organelle organization
|
GO:0010639 |
126 |
0.038
|
|
|
|
compound eye development
|
GO:0048749 |
1 |
0.038
|
|
|
|
somitogenesis
|
GO:0001756 |
2 |
0.038
|
|
|
|
glycosyl compound catabolic process
|
GO:1901658 |
413 |
0.038
|
|
|
|
regulation of ubiquitin protein transferase activity
|
GO:0051438 |
28 |
0.038
|
|
|
|
positive regulation of ligase activity
|
GO:0051351 |
19 |
0.037
|
|
|
|
cytokine mediated signaling pathway
|
GO:0019221 |
109 |
0.037
|
|
|
|
response to organic cyclic compound
|
GO:0014070 |
204 |
0.037
|
Human |
|
|
endomembrane system organization
|
GO:0010256 |
196 |
0.037
|
|
|
|
negative regulation of mitotic cell cycle
|
GO:0045930 |
102 |
0.036
|
|
|
|
positive regulation of cell death
|
GO:0010942 |
263 |
0.036
|
|
|
|
signal transduction by phosphorylation
|
GO:0023014 |
297 |
0.036
|
|
|
|
androgen biosynthetic process
|
GO:0006702 |
3 |
0.036
|
|
|
|
ribonucleotide catabolic process
|
GO:0009261 |
405 |
0.036
|
|
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
331 |
0.035
|
|
|
|
growth
|
GO:0040007 |
202 |
0.035
|
|
|
|
regulation of intrinsic apoptotic signaling pathway
|
GO:2001242 |
72 |
0.035
|
|
|
|
developmental programmed cell death
|
GO:0010623 |
3 |
0.035
|
|
|
|
positive regulation of cysteine type endopeptidase activity
|
GO:2001056 |
79 |
0.035
|
|
|
|
morphogenesis of embryonic epithelium
|
GO:0016331 |
4 |
0.034
|
|
|
|
cell morphogenesis
|
GO:0000902 |
296 |
0.034
|
|
|
|
mapk cascade
|
GO:0000165 |
288 |
0.034
|
|
|
|
metaphase anaphase transition of cell cycle
|
GO:0044784 |
21 |
0.034
|
|
|
|
nucleotide excision repair
|
GO:0006289 |
31 |
0.034
|
|
|
|
embryonic camera type eye morphogenesis
|
GO:0048596 |
2 |
0.034
|
|
|
|
negative regulation of cellular catabolic process
|
GO:0031330 |
83 |
0.034
|
|
|
|
negative regulation of phosphorylation
|
GO:0042326 |
174 |
0.034
|
|
|
|
negative regulation of transferase activity
|
GO:0051348 |
124 |
0.034
|
|
|
|
cell fate determination
|
GO:0001709 |
3 |
0.033
|
|
|
|
negative regulation of growth
|
GO:0045926 |
97 |
0.033
|
|
|
|
regulation of secretion by cell
|
GO:1903530 |
177 |
0.033
|
|
|
|
purine nucleoside triphosphate metabolic process
|
GO:0009144 |
412 |
0.033
|
|
|
|
gtp catabolic process
|
GO:0006184 |
237 |
0.033
|
|
|
|
positive regulation of chromatin modification
|
GO:1903310 |
30 |
0.033
|
|
|
|
histone ubiquitination
|
GO:0016574 |
31 |
0.033
|
|
|
|
response to hormone
|
GO:0009725 |
175 |
0.033
|
Human |
|
|
cellular response to transforming growth factor beta stimulus
|
GO:0071560 |
94 |
0.033
|
|
|
|
cell growth
|
GO:0016049 |
160 |
0.033
|
|
|
|
positive regulation of cell proliferation
|
GO:0008284 |
301 |
0.032
|
|
|
|
vesicle mediated transport
|
GO:0016192 |
371 |
0.032
|
|
|
|
negative regulation of apoptotic signaling pathway
|
GO:2001234 |
97 |
0.032
|
|
|
|
positive regulation of cellular component organization
|
GO:0051130 |
376 |
0.032
|
|
|
|
negative regulation of proteasomal protein catabolic process
|
GO:1901799 |
32 |
0.031
|
|
|
|
hemopoiesis
|
GO:0030097 |
180 |
0.031
|
|
|
|
negative regulation of mitotic metaphase anaphase transition
|
GO:0045841 |
17 |
0.031
|
|
|
|
chromatin assembly or disassembly
|
GO:0006333 |
78 |
0.031
|
|
|
|
nucleoside catabolic process
|
GO:0009164 |
408 |
0.031
|
|
|
|
regulation of nucleoside metabolic process
|
GO:0009118 |
209 |
0.031
|
|
|
|
regulation of anatomical structure morphogenesis
|
GO:0022603 |
286 |
0.031
|
|
|
|
cardiovascular system development
|
GO:0072358 |
262 |
0.031
|
|
|
|
mitotic cell cycle phase transition
|
GO:0044772 |
162 |
0.031
|
|
|
|
meiotic chromosome segregation
|
GO:0045132 |
4 |
0.030
|
|
|
|
negative regulation of cellular amino acid metabolic process
|
GO:0045763 |
2 |
0.030
|
|
|
|
vasculature development
|
GO:0001944 |
181 |
0.030
|
|
|
|
stress activated protein kinase signaling cascade
|
GO:0031098 |
94 |
0.030
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
183 |
0.030
|
|
|
|
negative regulation of gene expression epigenetic
|
GO:0045814 |
19 |
0.030
|
|
|
|
macromolecule deacylation
|
GO:0098732 |
41 |
0.030
|
|
|
|
regulation of jnk cascade
|
GO:0046328 |
73 |
0.030
|
|
|
|
negative regulation of catabolic process
|
GO:0009895 |
104 |
0.030
|
|
|
|
positive regulation of histone modification
|
GO:0031058 |
29 |
0.030
|
|
|
|
oxidation reduction process
|
GO:0055114 |
396 |
0.029
|
|
|
|
protein deubiquitination
|
GO:0016579 |
79 |
0.029
|
|
|
|
cellular response to abiotic stimulus
|
GO:0071214 |
117 |
0.029
|
Fly |
|
|
cell part morphogenesis
|
GO:0032990 |
137 |
0.029
|
|
|
|
regulation of locomotion
|
GO:0040012 |
329 |
0.029
|
|
|
|
negative regulation of intrinsic apoptotic signaling pathway
|
GO:2001243 |
40 |
0.029
|
|
|
|
intrinsic apoptotic signaling pathway by p53 class mediator
|
GO:0072332 |
37 |
0.029
|
|
|
|
spindle checkpoint
|
GO:0031577 |
26 |
0.029
|
|
|
|
guanosine containing compound metabolic process
|
GO:1901068 |
244 |
0.029
|
|
|
|
ras protein signal transduction
|
GO:0007265 |
73 |
0.028
|
|
|
|
embryonic camera type eye development
|
GO:0031076 |
2 |
0.028
|
|
|
|
dna methylation or demethylation
|
GO:0044728 |
19 |
0.028
|
|
|
|
positive regulation of proteolysis
|
GO:0045862 |
142 |
0.028
|
|
|
|
nucleotide catabolic process
|
GO:0009166 |
408 |
0.028
|
|
|
|
neuron differentiation
|
GO:0030182 |
138 |
0.028
|
|
|
|
purine ribonucleoside catabolic process
|
GO:0046130 |
398 |
0.028
|
|
|
|
regulation of transporter activity
|
GO:0032409 |
82 |
0.028
|
|
|
|
regulation of peptidase activity
|
GO:0052547 |
180 |
0.028
|
|
|
|
positive regulation of endopeptidase activity
|
GO:0010950 |
84 |
0.028
|
|
|
|
single organism reproductive process
|
GO:0044702 |
98 |
0.028
|
|
|
|
mitotic cell cycle process
|
GO:1903047 |
286 |
0.028
|
|
|
|
regulation of secretion
|
GO:0051046 |
194 |
0.028
|
|
|
|
ribonucleoside monophosphate metabolic process
|
GO:0009161 |
187 |
0.027
|
|
|
|
positive regulation of nucleotide metabolic process
|
GO:0045981 |
230 |
0.027
|
|
|
|
response to estrogen
|
GO:0043627 |
47 |
0.027
|
Human |
|
|
positive regulation of peptidase activity
|
GO:0010952 |
88 |
0.027
|
|
|
|
regulation of dna metabolic process
|
GO:0051052 |
153 |
0.027
|
|
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.027
|
|
|
|
protein modification by small protein removal
|
GO:0070646 |
92 |
0.027
|
|
|
|
positive regulation of ras gtpase activity
|
GO:0032320 |
117 |
0.027
|
|
|
|
negative regulation of cellular amine metabolic process
|
GO:0033239 |
3 |
0.027
|
|
|
|
cell projection morphogenesis
|
GO:0048858 |
129 |
0.027
|
|
|
|
positive regulation of apoptotic process
|
GO:0043065 |
246 |
0.027
|
|
|
|
response to oxidative stress
|
GO:0006979 |
121 |
0.027
|
|
|
|
transmembrane transport
|
GO:0055085 |
399 |
0.027
|
|
|
|
positive regulation of synaptic transmission
|
GO:0050806 |
4 |
0.027
|
|
|
|
maintenance of location
|
GO:0051235 |
112 |
0.026
|
|
|
|
metaphase anaphase transition of mitotic cell cycle
|
GO:0007091 |
21 |
0.026
|
|
|
|
positive regulation of sequence specific dna binding transcription factor activity
|
GO:0051091 |
131 |
0.026
|
Fly |
|
|
negative regulation of axonogenesis
|
GO:0050771 |
4 |
0.026
|
|
|
|
mitotic sister chromatid separation
|
GO:0051306 |
18 |
0.026
|
|
|
|
negative regulation of proteolysis involved in cellular protein catabolic process
|
GO:1903051 |
35 |
0.026
|
|
|
|
purine ribonucleotide catabolic process
|
GO:0009154 |
404 |
0.026
|
|
|
|
mating
|
GO:0007618 |
1 |
0.026
|
|
|
|
microtubule cytoskeleton organization
|
GO:0000226 |
176 |
0.025
|
|
|
|
regulation of mapk cascade
|
GO:0043408 |
262 |
0.025
|
|
|
|
negative regulation of sequence specific dna binding transcription factor activity
|
GO:0043433 |
89 |
0.025
|
|
|
|
ion homeostasis
|
GO:0050801 |
230 |
0.025
|
|
|
|
regulation of mitotic sister chromatid separation
|
GO:0010965 |
27 |
0.025
|
|
|
|
aging
|
GO:0007568 |
66 |
0.025
|
|
|
|
positive regulation of cell differentiation
|
GO:0045597 |
211 |
0.025
|
|
|
|
reproductive process
|
GO:0022414 |
106 |
0.024
|
|
|
|
transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0007178 |
125 |
0.024
|
|
|
|
regulation of chromatin modification
|
GO:1903308 |
51 |
0.024
|
Fly |
|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.024
|
|
|
|
response to light stimulus
|
GO:0009416 |
87 |
0.024
|
|
|
|
cytoplasmic transport
|
GO:0016482 |
379 |
0.024
|
|
|
|
cellular chemical homeostasis
|
GO:0055082 |
180 |
0.024
|
|
|
|
g2 dna damage checkpoint
|
GO:0031572 |
26 |
0.024
|
|
|
|
segmentation
|
GO:0035282 |
4 |
0.024
|
|
|
|
regulation of cellular component biogenesis
|
GO:0044087 |
281 |
0.024
|
|
|
|
regulation of neuronal synaptic plasticity
|
GO:0048168 |
1 |
0.024
|
|
|
|
dna damage checkpoint
|
GO:0000077 |
68 |
0.024
|
Fly |
|
|
neuron projection development
|
GO:0031175 |
106 |
0.023
|
|
|
|
positive regulation of chromosome organization
|
GO:2001252 |
41 |
0.023
|
|
|
|
negative regulation of chromatin silencing
|
GO:0031936 |
4 |
0.023
|
|
|
|
cell morphogenesis involved in differentiation
|
GO:0000904 |
144 |
0.023
|
|
|
|
regulation of gtpase activity
|
GO:0043087 |
180 |
0.023
|
|
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
175 |
0.023
|
|
|
|
circulatory system development
|
GO:0072359 |
262 |
0.023
|
|
|
|
purine nucleotide catabolic process
|
GO:0006195 |
405 |
0.022
|
|
|
|
hindbrain development
|
GO:0030902 |
3 |
0.022
|
|
|
|
regulation of cellular response to growth factor stimulus
|
GO:0090287 |
76 |
0.022
|
|
|
|
negative regulation of cellular protein catabolic process
|
GO:1903363 |
38 |
0.022
|
|
|
|
dna integrity checkpoint
|
GO:0031570 |
71 |
0.022
|
Fly |
|
|
spermatid differentiation
|
GO:0048515 |
4 |
0.022
|
|
|
|
positive regulation of protein catabolic process
|
GO:0045732 |
75 |
0.022
|
|
|
|
negative regulation of protein catabolic process
|
GO:0042177 |
59 |
0.022
|
|
|
|
organophosphate catabolic process
|
GO:0046434 |
430 |
0.022
|
|
|
|
single organism membrane organization
|
GO:0044802 |
268 |
0.022
|
|
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
140 |
0.022
|
|
|
|
regulation of histone acetylation
|
GO:0035065 |
19 |
0.021
|
Fly |
|
|
blood vessel development
|
GO:0001568 |
172 |
0.021
|
|
|
|
ribonucleoside monophosphate catabolic process
|
GO:0009158 |
158 |
0.021
|
|
|
|
cellular senescence
|
GO:0090398 |
34 |
0.021
|
|
|
|
protein monoubiquitination
|
GO:0006513 |
39 |
0.021
|
|
|
|
intrinsic apoptotic signaling pathway in response to dna damage
|
GO:0008630 |
50 |
0.021
|
|
|
|
negative regulation of protein modification by small protein conjugation or removal
|
GO:1903321 |
41 |
0.021
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
179 |
0.021
|
|
|
|
single organism cellular localization
|
GO:1902580 |
332 |
0.021
|
|
|
|
secretion by cell
|
GO:0032940 |
226 |
0.021
|
|
|
|
regulation of protein complex assembly
|
GO:0043254 |
147 |
0.021
|
|
|
|
microtubule based process
|
GO:0007017 |
210 |
0.021
|
|
|
|
regulation of stem cell differentiation
|
GO:2000736 |
56 |
0.021
|
|
|
|
system process
|
GO:0003008 |
349 |
0.021
|
|
|
|
regulation of binding
|
GO:0051098 |
111 |
0.021
|
|
|
|
sister chromatid segregation
|
GO:0000819 |
54 |
0.021
|
|
|
|
embryonic eye morphogenesis
|
GO:0048048 |
2 |
0.020
|
|
|
|
negative regulation of protein ubiquitination
|
GO:0031397 |
35 |
0.020
|
|
|
|
regulation of chromosome segregation
|
GO:0051983 |
44 |
0.020
|
|
|
|
rhythmic behavior
|
GO:0007622 |
2 |
0.020
|
|
|
|
histone deacetylation
|
GO:0016575 |
32 |
0.020
|
|
|
|
regulation of cell cycle phase transition
|
GO:1901987 |
126 |
0.020
|
|
|
|
leukocyte activation
|
GO:0045321 |
164 |
0.020
|
|
|
|
negative regulation of sister chromatid segregation
|
GO:0033046 |
17 |
0.020
|
|
|
|
regulation of ossification
|
GO:0030278 |
58 |
0.020
|
|
|
|
purine nucleoside monophosphate metabolic process
|
GO:0009126 |
186 |
0.020
|
|
|
|
protein targeting
|
GO:0006605 |
187 |
0.020
|
|
|
|
protein oligomerization
|
GO:0051259 |
173 |
0.020
|
|
|
|
regulation of stress activated protein kinase signaling cascade
|
GO:0070302 |
85 |
0.020
|
|
|
|
protein autophosphorylation
|
GO:0046777 |
123 |
0.020
|
|
|
|
cell aging
|
GO:0007569 |
52 |
0.020
|
|
|
|
ion transmembrane transport
|
GO:0034220 |
338 |
0.020
|
|
|
|
regulation of ligase activity
|
GO:0051340 |
29 |
0.020
|
|
|
|
response to steroid hormone
|
GO:0048545 |
80 |
0.020
|
Human |
|
|
gtp metabolic process
|
GO:0046039 |
239 |
0.020
|
|
|
|
steroid metabolic process
|
GO:0008202 |
94 |
0.019
|
|
|
|
lens development in camera type eye
|
GO:0002088 |
2 |
0.019
|
|
|
|
positive regulation of response to dna damage stimulus
|
GO:2001022 |
43 |
0.019
|
|
|
|
embryonic organ development
|
GO:0048568 |
36 |
0.019
|
|
|
|
regulation of synaptic plasticity
|
GO:0048167 |
3 |
0.019
|
|
|
|
regulation of cytoskeleton organization
|
GO:0051493 |
177 |
0.019
|
|
|
|
carbohydrate metabolic process
|
GO:0005975 |
207 |
0.019
|
|
|
|
telomere organization
|
GO:0032200 |
33 |
0.019
|
|
|
|
small gtpase mediated signal transduction
|
GO:0007264 |
78 |
0.019
|
|
|
|
inner ear morphogenesis
|
GO:0042472 |
4 |
0.019
|
|
|
|
regulation of cardiac muscle cell proliferation
|
GO:0060043 |
4 |
0.019
|
|
|
|
anterior posterior axis specification
|
GO:0009948 |
2 |
0.019
|
|
|
|
response to transforming growth factor beta
|
GO:0071559 |
94 |
0.019
|
|
|
|
cell activation
|
GO:0001775 |
213 |
0.019
|
|
|
|
positive regulation of insulin like growth factor receptor signaling pathway
|
GO:0043568 |
4 |
0.019
|
|
|
|
dna replication
|
GO:0006260 |
116 |
0.019
|
Human |
|
|
cellular component disassembly
|
GO:0022411 |
92 |
0.018
|
|
|
|
regulation of mitotic cell cycle phase transition
|
GO:1901990 |
118 |
0.018
|
|
|
|
multi organism reproductive process
|
GO:0044703 |
54 |
0.018
|
|
|
|
interspecies interaction between organisms
|
GO:0044419 |
156 |
0.018
|
|
|
|
dna damage response signal transduction resulting in transcription
|
GO:0042772 |
12 |
0.018
|
Human |
|
|
positive regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043280 |
69 |
0.018
|
|
|
|
positive regulation of ossification
|
GO:0045778 |
32 |
0.018
|
|
|
|
regulation of cellular component movement
|
GO:0051270 |
334 |
0.018
|
|
|
|
regulation of cardiac muscle tissue growth
|
GO:0055021 |
4 |
0.018
|
|
|
|
pharynx development
|
GO:0060465 |
1 |
0.018
|
|
|
|
blood vessel morphogenesis
|
GO:0048514 |
162 |
0.018
|
|
|
|
negative regulation of metaphase anaphase transition of cell cycle
|
GO:1902100 |
17 |
0.018
|
|
|
|
purine ribonucleoside monophosphate metabolic process
|
GO:0009167 |
186 |
0.018
|
|
|
|
neuron development
|
GO:0048666 |
113 |
0.018
|
|
|
|
wnt signaling pathway
|
GO:0016055 |
156 |
0.018
|
|
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
267 |
0.018
|
|
|
|
positive regulation of protein transport
|
GO:0051222 |
135 |
0.018
|
|
|
|
generation of neurons
|
GO:0048699 |
152 |
0.018
|
|
|
|
histone h4 k12 acetylation
|
GO:0043983 |
6 |
0.018
|
Human |
|
|
regulation of cell morphogenesis
|
GO:0022604 |
153 |
0.018
|
|
|
|
cellular response to ionizing radiation
|
GO:0071479 |
32 |
0.018
|
Fly |
|
|
negative regulation of hydrolase activity
|
GO:0051346 |
182 |
0.018
|
|
|
|
neurogenesis
|
GO:0022008 |
169 |
0.018
|
|
|
|
response to cocaine
|
GO:0042220 |
1 |
0.018
|
|
|
|
regulation of anatomical structure size
|
GO:0090066 |
101 |
0.018
|
|
|
|
negative regulation of developmental process
|
GO:0051093 |
247 |
0.018
|
|
|
|
neurotransmitter secretion
|
GO:0007269 |
4 |
0.017
|
|
|
|
regulation of chromatin organization
|
GO:1902275 |
56 |
0.017
|
Fly |
|
|
regulation of response to external stimulus
|
GO:0032101 |
222 |
0.017
|
|
|
|
regulation of stress activated mapk cascade
|
GO:0032872 |
84 |
0.017
|
|
|
|
protein deacetylation
|
GO:0006476 |
38 |
0.017
|
|
|
|
regulation of ion transport
|
GO:0043269 |
189 |
0.017
|
|
|
|
regulation of protein transport
|
GO:0051223 |
213 |
0.017
|
|
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
267 |
0.017
|
|
|
|
transforming growth factor beta receptor signaling pathway
|
GO:0007179 |
76 |
0.017
|
|
|
|
negative regulation of kinase activity
|
GO:0033673 |
106 |
0.017
|
|
|
|
regulation of transmembrane transport
|
GO:0034762 |
139 |
0.017
|
|
|
|
defense response
|
GO:0006952 |
315 |
0.017
|
|
|
|
regulation of cytoplasmic transport
|
GO:1903649 |
149 |
0.017
|
|
|
|
mesenchyme development
|
GO:0060485 |
59 |
0.017
|
|
|
|
regulation of cellular ketone metabolic process by regulation of transcription from rna polymerase ii promoter
|
GO:0072364 |
3 |
0.017
|
|
|
|
positive regulation of dendrite morphogenesis
|
GO:0050775 |
3 |
0.017
|
|
|
|
motor neuron axon guidance
|
GO:0008045 |
2 |
0.017
|
|
|
|
embryo development
|
GO:0009790 |
123 |
0.017
|
|
|
|
rho protein signal transduction
|
GO:0007266 |
26 |
0.017
|
|
|
|
immune response
|
GO:0006955 |
307 |
0.017
|
|
|
|
regulation of metal ion transport
|
GO:0010959 |
120 |
0.017
|
|
|
|
regulation of mitotic sister chromatid segregation
|
GO:0033047 |
27 |
0.017
|
|
|
|
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0090100 |
41 |
0.017
|
|
|
|
response to oxygen containing compound
|
GO:1901700 |
369 |
0.017
|
Human |
|
|
cellular homeostasis
|
GO:0019725 |
196 |
0.017
|
|
|
|
positive regulation of wnt signaling pathway
|
GO:0030177 |
54 |
0.017
|
|
|
|
establishment of protein localization to organelle
|
GO:0072594 |
172 |
0.016
|
|
|
|
stress activated mapk cascade
|
GO:0051403 |
93 |
0.016
|
|
|
|
dna catabolic process
|
GO:0006308 |
49 |
0.016
|
|
|
|
response to oxygen levels
|
GO:0070482 |
100 |
0.016
|
|
|
|
positive regulation of gtpase activity
|
GO:0043547 |
166 |
0.016
|
|
|
|
positive regulation of osteoblast differentiation
|
GO:0045669 |
23 |
0.016
|
|
|
|
startle response
|
GO:0001964 |
3 |
0.016
|
|
|
|
positive regulation of immune response
|
GO:0050778 |
159 |
0.016
|
|
|
|
blastoderm segmentation
|
GO:0007350 |
2 |
0.016
|
|
|
|
multicellular organism reproduction
|
GO:0032504 |
42 |
0.016
|
|
|
|
regulation of dna repair
|
GO:0006282 |
47 |
0.016
|
|
|
|
regeneration
|
GO:0031099 |
4 |
0.016
|
|
|
|
viral life cycle
|
GO:0019058 |
132 |
0.016
|
|
|
|
circadian behavior
|
GO:0048512 |
2 |
0.016
|
|
|
|
intracellular protein transport
|
GO:0006886 |
270 |
0.016
|
|
|
|
metencephalon development
|
GO:0022037 |
2 |
0.016
|
|
|
|
rna interference
|
GO:0016246 |
4 |
0.016
|
|
|
|
cation homeostasis
|
GO:0055080 |
189 |
0.016
|
|
|
|
osteoblast differentiation
|
GO:0001649 |
92 |
0.016
|
|
|
|
regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043281 |
116 |
0.016
|
|
|
|
positive regulation of transporter activity
|
GO:0032411 |
32 |
0.016
|
|
|
|
cellular response to cytokine stimulus
|
GO:0071345 |
181 |
0.016
|
|
|
|
sequestering of calcium ion
|
GO:0051208 |
17 |
0.016
|
|
|
|
photoreceptor cell maintenance
|
GO:0045494 |
13 |
0.015
|
|
|
|
mitotic dna damage checkpoint
|
GO:0044773 |
28 |
0.015
|
|
|
|
negative regulation of multicellular organismal process
|
GO:0051241 |
317 |
0.015
|
Human |
|
|
regulation of intracellular transport
|
GO:0032386 |
195 |
0.015
|
|
|
|
positive regulation of stress activated protein kinase signaling cascade
|
GO:0070304 |
61 |
0.015
|
|
|
|
positive regulation of cell growth
|
GO:0030307 |
48 |
0.015
|
|
|
|
peptidyl tyrosine phosphorylation
|
GO:0018108 |
170 |
0.015
|
|
|
|
positive regulation of ubiquitin protein transferase activity
|
GO:0051443 |
18 |
0.015
|
|
|
|
reproduction
|
GO:0000003 |
63 |
0.015
|
|
|
|
response to drug
|
GO:0042493 |
81 |
0.015
|
|
|
|
axis elongation
|
GO:0003401 |
4 |
0.015
|
|
|
|
negative regulation of wnt signaling pathway
|
GO:0030178 |
69 |
0.015
|
|
|
|
ossification
|
GO:0001503 |
121 |
0.015
|
|
|
|
endocytosis
|
GO:0006897 |
159 |
0.015
|
|
|
|
cellular modified amino acid metabolic process
|
GO:0006575 |
64 |
0.015
|
|
|
|
cellular response to oxygen levels
|
GO:0071453 |
55 |
0.015
|
|
|
|
positive regulation of peptidyl tyrosine phosphorylation
|
GO:0050731 |
85 |
0.015
|
|
|
|
cellular cation homeostasis
|
GO:0030003 |
163 |
0.015
|
|
|
|
histone h2b conserved c terminal lysine deubiquitination
|
GO:0035616 |
1 |
0.015
|
|
|
|
embryonic hindlimb morphogenesis
|
GO:0035116 |
2 |
0.015
|
|
|
|
positive regulation of purine nucleotide catabolic process
|
GO:0033123 |
185 |
0.015
|
|
|
|
response to inorganic substance
|
GO:0010035 |
127 |
0.014
|
|
|
|
hindlimb morphogenesis
|
GO:0035137 |
2 |
0.014
|
|
|
|
sexual reproduction
|
GO:0019953 |
37 |
0.014
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
289 |
0.014
|
|
|
|
cell morphogenesis involved in neuron differentiation
|
GO:0048667 |
44 |
0.014
|
|
