Homo sapiens

68 known processes

SIRT6

sirtuin 6

(Aliases: SIR2L6)

SIRT6 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
rab protein signal transduction GO:0032482 4 0.219
defense response GO:0006952 315 0.158
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.142
small gtpase mediated signal transduction GO:0007264 78 0.118
negative regulation of protein metabolic process GO:0051248 391 0.111
anterior posterior axis specification GO:0009948 2 0.108
cellular response to dna damage stimulus GO:0006974 379 0.108
regulation of establishment of protein localization GO:0070201 242 0.101
negative regulation of apoptotic process GO:0043066 316 0.099
female gamete generation GO:0007292 2 0.097
amine metabolic process GO:0009308 44 0.090
negative regulation of intracellular signal transduction GO:1902532 183 0.079
cytokine production GO:0001816 247 0.078
oogenesis GO:0048477 2 0.075
cytoplasmic transport GO:0016482 379 0.075
regulation of transferase activity GO:0051338 355 0.074
negative regulation of protein phosphorylation GO:0001933 140 0.071
cellular defense response GO:0006968 2 0.068
intracellular protein transport GO:0006886 270 0.067
regulation of cellular amino acid metabolic process GO:0006521 6 0.065
covalent chromatin modification GO:0016569 254 0.065
positive regulation of transport GO:0051050 336 0.063
membrane organization GO:0061024 292 0.062
ras protein signal transduction GO:0007265 73 0.062
protein alkylation GO:0008213 74 0.062
positive regulation of apoptotic process GO:0043065 246 0.060
lipid localization GO:0010876 106 0.060
chromatin modification GO:0016568 298 0.059
peptidyl serine phosphorylation GO:0018105 101 0.059
immune response GO:0006955 307 0.059
regulation of proteolysis GO:0030162 293 0.058
i kappab kinase nf kappab signaling GO:0007249 166 0.057
regulation of cellular ketone metabolic process GO:0010565 50 0.056
methylation GO:0032259 106 0.056
protein modification by small protein conjugation GO:0032446 342 0.054
defense response to other organism GO:0098542 129 0.053
defense response to fungus GO:0050832 4 0.052
response to fungus GO:0009620 4 0.051
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.051
regulation of protein kinase activity GO:0045859 289 0.051
histone lysine methylation GO:0034968 50 0.051
macromolecule methylation GO:0043414 97 0.050
positive regulation of programmed cell death GO:0043068 249 0.050
protein methylation GO:0006479 74 0.050
histone methylation GO:0016571 60 0.050
cellular amino acid metabolic process GO:0006520 116 0.049
response to external biotic stimulus GO:0043207 261 0.049
negative regulation of cellular protein metabolic process GO:0032269 353 0.049
regulation of protein localization GO:0032880 296 0.049
negative regulation of phosphorus metabolic process GO:0010563 267 0.048
circadian behavior GO:0048512 2 0.048
neurofilament bundle assembly GO:0033693 2 0.047
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.047
segmentation GO:0035282 4 0.046
organonitrogen compound biosynthetic process GO:1901566 200 0.046
regulation of cellular amine metabolic process GO:0033238 11 0.045
single organism membrane organization GO:0044802 268 0.045
histone modification GO:0016570 251 0.045
regulation of meiotic cell cycle GO:0051445 4 0.044
negative regulation of catalytic activity GO:0043086 335 0.043
protein processing GO:0016485 226 0.042
lipid metabolic process GO:0006629 381 0.042
memory GO:0007613 3 0.042
protein ubiquitination GO:0016567 314 0.042
cellular amine metabolic process GO:0044106 41 0.042
regulation of nucleocytoplasmic transport GO:0046822 98 0.041
negative regulation of cellular amine metabolic process GO:0033239 3 0.041
positive regulation of protein phosphorylation GO:0001934 313 0.041
leukotriene metabolic process GO:0006691 10 0.041
protein catabolic process GO:0030163 325 0.041
post embryonic development GO:0009791 2 0.041
response to other organism GO:0051707 261 0.040
response to cytokine GO:0034097 232 0.040
positive regulation of nf kappab transcription factor activity GO:0051092 81 0.040
neurofilament cytoskeleton organization GO:0060052 2 0.039
epithelial cell differentiation GO:0030855 141 0.039
cellular protein catabolic process GO:0044257 261 0.038
positive regulation of cell death GO:0010942 263 0.038
regeneration GO:0031099 4 0.038
regulation of nucleoside metabolic process GO:0009118 209 0.038
ribonucleotide catabolic process GO:0009261 405 0.038
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.038
regulation of translation GO:0006417 89 0.037
regulation of intracellular protein transport GO:0033157 123 0.037
positive regulation of cellular catabolic process GO:0031331 284 0.037
amide biosynthetic process GO:0043604 15 0.036
translation GO:0006412 132 0.036
positive regulation of protein transport GO:0051222 135 0.036
response to bacterium GO:0009617 144 0.035
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.035
positive regulation of catabolic process GO:0009896 310 0.035
positive regulation of nucleotide metabolic process GO:0045981 230 0.035
cation transport GO:0006812 331 0.035
single organism cellular localization GO:1902580 332 0.035
regulation of circadian sleep wake cycle GO:0042749 2 0.035
protein maturation GO:0051604 233 0.034
innate immune response GO:0045087 178 0.034
enzyme linked receptor protein signaling pathway GO:0007167 303 0.034
rhythmic behavior GO:0007622 2 0.034
establishment of protein localization to organelle GO:0072594 172 0.034
angiogenesis GO:0001525 147 0.033
positive regulation of rab gtpase activity GO:0032851 39 0.033
secretion GO:0046903 254 0.033
positive regulation of transferase activity GO:0051347 227 0.033
protein localization to organelle GO:0033365 280 0.032
regulation of protein transport GO:0051223 213 0.032
cellular macromolecule catabolic process GO:0044265 380 0.032
cellular response to oxygen containing compound GO:1901701 276 0.032
cellular response to molecule of bacterial origin GO:0071219 62 0.032
protein targeting GO:0006605 187 0.032
response to biotic stimulus GO:0009607 276 0.031
nucleoside triphosphate metabolic process GO:0009141 422 0.031
positive regulation of immune system process GO:0002684 283 0.031
lipid biosynthetic process GO:0008610 177 0.031
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.031
Human
determination of adult lifespan GO:0008340 2 0.031
Fly
small molecule biosynthetic process GO:0044283 157 0.031
nucleocytoplasmic transport GO:0006913 176 0.031
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.031
regulation of protein processing GO:0070613 150 0.030
spermatid differentiation GO:0048515 4 0.030
purine containing compound catabolic process GO:0072523 411 0.030
cellular response to growth factor stimulus GO:0071363 197 0.030
response to oxygen containing compound GO:1901700 369 0.030
protein autophosphorylation GO:0046777 123 0.030
hematopoietic or lymphoid organ development GO:0048534 186 0.030
chromatin organization GO:0006325 351 0.029
negative regulation of programmed cell death GO:0043069 321 0.029
neuromuscular junction development GO:0007528 3 0.029
posttranscriptional regulation of gene expression GO:0010608 213 0.029
positive regulation of cytokine production GO:0001819 167 0.029
ectoderm development GO:0007398 3 0.029
positive regulation of cellular amine metabolic process GO:0033240 7 0.029
negative regulation of protein maturation GO:1903318 142 0.029
negative regulation of muscle contraction GO:0045932 3 0.029
glycosyl compound catabolic process GO:1901658 413 0.029
intrinsic apoptotic signaling pathway GO:0097193 127 0.029
response to molecule of bacterial origin GO:0002237 82 0.029
protein localization to membrane GO:0072657 160 0.028
cell cycle arrest GO:0007050 71 0.028
negative regulation of proteolysis GO:0045861 132 0.027
regulation of cellular response to stress GO:0080135 244 0.027
positive regulation of protein kinase activity GO:0045860 190 0.027
purine ribonucleotide catabolic process GO:0009154 404 0.027
positive regulation of immune response GO:0050778 159 0.027
negative regulation of transport GO:0051051 176 0.027
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.027
vesicle mediated transport GO:0016192 371 0.027
response to lipid GO:0033993 206 0.027
apoptotic signaling pathway GO:0097190 268 0.026
regulation of protein targeting GO:1903533 91 0.026
negative regulation of phosphorylation GO:0042326 174 0.026
activation of protein kinase activity GO:0032147 90 0.026
secretion by cell GO:0032940 226 0.026
ribonucleoside catabolic process GO:0042454 406 0.026
regulation of cytokine production GO:0001817 232 0.026
regulation of innate immune response GO:0045088 97 0.026
regulation of synaptic plasticity GO:0048167 3 0.026
nitrogen compound transport GO:0071705 191 0.026
cellular response to endogenous stimulus GO:0071495 336 0.026
negative regulation of transferase activity GO:0051348 124 0.026
reactive oxygen species biosynthetic process GO:1903409 4 0.026
regulation of protein catabolic process GO:0042176 155 0.026
negative regulation of multicellular organismal process GO:0051241 317 0.026
regulation of binding GO:0051098 111 0.025
osteoblast differentiation GO:0001649 92 0.025
response to organonitrogen compound GO:0010243 156 0.025
lipid transport GO:0006869 90 0.025
organic anion transport GO:0015711 103 0.025
purine ribonucleoside metabolic process GO:0046128 437 0.025
cellular ketone metabolic process GO:0042180 80 0.025
regulation of rab protein signal transduction GO:0032483 39 0.025
canonical wnt signaling pathway GO:0060070 116 0.025
tripartite regional subdivision GO:0007351 2 0.025
circadian sleep wake cycle GO:0042745 2 0.025
neural tube patterning GO:0021532 2 0.025
oocyte differentiation GO:0009994 2 0.025
organic hydroxy compound transport GO:0015850 63 0.024
sleep GO:0030431 2 0.024
mitochondrion organization GO:0007005 156 0.024
regulation of protein maturation GO:1903317 150 0.024
associative learning GO:0008306 1 0.024
regulation of purine nucleotide metabolic process GO:1900542 264 0.024
modification dependent protein catabolic process GO:0019941 209 0.024
ribonucleoside triphosphate catabolic process GO:0009203 391 0.024
microtubule based process GO:0007017 210 0.023
regulation of intracellular transport GO:0032386 195 0.023
peptidyl serine modification GO:0018209 106 0.023
chemical homeostasis GO:0048878 306 0.023
regulation of kinase activity GO:0043549 314 0.023
regulation of rab gtpase activity GO:0032313 39 0.023
response to abiotic stimulus GO:0009628 336 0.023
negative regulation of cell death GO:0060548 345 0.023
signal transduction by p53 class mediator GO:0072331 72 0.023
regulation of cytoplasmic transport GO:1903649 149 0.023
response to organic cyclic compound GO:0014070 204 0.023
leukocyte activation GO:0045321 164 0.023
intracellular mrna localization GO:0008298 1 0.022
positive regulation of digestive system process GO:0060456 2 0.022
wnt signaling pathway GO:0016055 156 0.022
regulation of defense response GO:0031347 154 0.022
interspecies interaction between organisms GO:0044419 156 0.022
morphogenesis of embryonic epithelium GO:0016331 4 0.022
negative regulation of cell differentiation GO:0045596 171 0.022
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.022
defense response to bacterium GO:0042742 63 0.022
response to uv GO:0009411 73 0.021
positive regulation of defense response GO:0031349 87 0.021
regulation of cell cycle GO:0051726 393 0.021
regulation of secretion GO:0051046 194 0.021
regulation of ras protein signal transduction GO:0046578 155 0.021
spermatid development GO:0007286 4 0.021
system process GO:0003008 349 0.021
motor neuron axon guidance GO:0008045 2 0.021
cellular response to cytokine stimulus GO:0071345 181 0.021
regulation of nucleotide metabolic process GO:0006140 269 0.021
negative regulation of chromatin silencing GO:0031936 4 0.021
regulation of dna metabolic process GO:0051052 153 0.021
cellular lipid metabolic process GO:0044255 303 0.021
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.021
cell substrate adhesion GO:0031589 132 0.021
positive regulation of phosphorylation GO:0042327 394 0.021
cellular response to biotic stimulus GO:0071216 71 0.021
positive regulation of cell cycle GO:0045787 140 0.021
negative regulation of hydrolase activity GO:0051346 182 0.020
negative regulation of cell cycle GO:0045786 193 0.020
negative regulation of cell proliferation GO:0008285 228 0.020
positive regulation of hydrolase activity GO:0051345 331 0.020
purine nucleotide catabolic process GO:0006195 405 0.020
anion transport GO:0006820 161 0.020
cell development GO:0048468 328 0.020
Rat
monocarboxylic acid metabolic process GO:0032787 185 0.020
nucleoside monophosphate metabolic process GO:0009123 191 0.020
maintenance of location GO:0051235 112 0.020
kidney morphogenesis GO:0060993 19 0.020
regulation of protein secretion GO:0050708 86 0.020
sodium ion transport GO:0006814 61 0.019
nucleotide catabolic process GO:0009166 408 0.019
nucleotide binding oligomerization domain containing signaling pathway GO:0070423 4 0.019
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.019
protein polyubiquitination GO:0000209 110 0.019
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.019
regulation of immune response GO:0050776 201 0.019
negative regulation of phosphate metabolic process GO:0045936 267 0.019
biological adhesion GO:0022610 331 0.018
positive regulation of multi organism process GO:0043902 56 0.018
nuclear import GO:0051170 106 0.018
myeloid cell differentiation GO:0030099 117 0.018
response to hormone GO:0009725 175 0.018
maintenance of protein location GO:0045185 57 0.018
negative regulation of nf kappab transcription factor activity GO:0032088 51 0.018
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.018
positive regulation of proteolysis GO:0045862 142 0.018
single organism reproductive process GO:0044702 98 0.018
regulation of cell adhesion GO:0030155 166 0.018
cell cell signaling GO:0007267 155 0.018
regulation of peptidase activity GO:0052547 180 0.018
tissue migration GO:0090130 119 0.018
cell projection morphogenesis GO:0048858 129 0.018
gtp catabolic process GO:0006184 237 0.018
gtp metabolic process GO:0046039 239 0.018
regulation of cell cycle process GO:0010564 266 0.017
renal sodium ion absorption GO:0070294 2 0.017
regulation of mapk cascade GO:0043408 262 0.017
cellular homeostasis GO:0019725 196 0.017
positive regulation of peptidase activity GO:0010952 88 0.017
neural tube formation GO:0001841 3 0.017
protein import GO:0017038 130 0.017
endothelial cell proliferation GO:0001935 65 0.017
compound eye development GO:0048749 1 0.017
regulation of cellular component movement GO:0051270 334 0.017
organophosphate catabolic process GO:0046434 430 0.017
ribonucleoside triphosphate metabolic process GO:0009199 412 0.017
cellular amide metabolic process GO:0043603 69 0.017
cd4 positive alpha beta t cell cytokine production GO:0035743 4 0.017
positive regulation of synaptic transmission GO:0050806 4 0.017
amide transport GO:0042886 76 0.017
purine ribonucleoside catabolic process GO:0046130 398 0.017
single organism nuclear import GO:1902593 104 0.017
positive regulation of cell proliferation GO:0008284 301 0.017
regulation of cell activation GO:0050865 125 0.016
embryonic hemopoiesis GO:0035162 4 0.016
purine nucleoside triphosphate catabolic process GO:0009146 392 0.016
regulation of dna binding GO:0051101 37 0.016
inorganic ion transmembrane transport GO:0098660 231 0.016
positive regulation of kinase activity GO:0033674 204 0.016
regulation of protein serine threonine kinase activity GO:0071900 179 0.016
organelle localization GO:0051640 84 0.016
regulation of endopeptidase activity GO:0052548 170 0.016
peripheral nervous system development GO:0007422 2 0.016
peptidyl lysine modification GO:0018205 144 0.016
protein k33 linked ubiquitination GO:1990390 1 0.016
carboxylic acid biosynthetic process GO:0046394 97 0.016
positive regulation of nucleotide catabolic process GO:0030813 185 0.016
innate immune response activating signal transduction GO:0002758 48 0.016
regulation of cell migration GO:0030334 289 0.016
epithelium development GO:0060429 227 0.016
growth GO:0040007 202 0.016
Rat
protein localization to nucleus GO:0034504 136 0.016
multicellular organismal aging GO:0010259 3 0.016
Fly
negative regulation of dna metabolic process GO:0051053 57 0.016
glycerolipid metabolic process GO:0046486 107 0.016
regulation of glial cell proliferation GO:0060251 4 0.016
cd4 positive alpha beta t cell differentiation GO:0043367 4 0.015
long term synaptic potentiation GO:0060291 1 0.015
demethylation GO:0070988 37 0.015
negative regulation of developmental process GO:0051093 247 0.015
transcription factor import into nucleus GO:0042991 40 0.015
circadian sleep wake cycle sleep GO:0050802 2 0.015
golgi vesicle transport GO:0048193 80 0.015
nuclear transport GO:0051169 179 0.015
actin filament based movement GO:0030048 17 0.015
protein targeting to nucleus GO:0044744 104 0.015
oxidation reduction process GO:0055114 396 0.015
nucleoside phosphate catabolic process GO:1901292 412 0.015
cardiac muscle contraction GO:0060048 34 0.015
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.015
regulation of multi organism process GO:0043900 157 0.015
cytokine mediated signaling pathway GO:0019221 109 0.015
interleukin 8 production GO:0032637 51 0.015
positive regulation of protein secretion GO:0050714 60 0.015
transmembrane transport GO:0055085 399 0.015
negative regulation of intracellular transport GO:0032387 60 0.015
endomembrane system organization GO:0010256 196 0.015
positive regulation of glial cell proliferation GO:0060252 2 0.015
positive regulation of lipid transport GO:0032370 22 0.015
fatty acid derivative metabolic process GO:1901568 35 0.015
oocyte development GO:0048599 1 0.015
single organism carbohydrate metabolic process GO:0044723 193 0.015
Mouse
organic acid biosynthetic process GO:0016053 97 0.015
purine nucleoside monophosphate metabolic process GO:0009126 186 0.015
negative regulation of interleukin 8 biosynthetic process GO:0045415 3 0.015
nucleoside triphosphate catabolic process GO:0009143 394 0.015
locomotory behavior GO:0007626 1 0.015
amino acid transport GO:0006865 28 0.014
embryonic epithelial tube formation GO:0001838 4 0.014
alpha amino acid metabolic process GO:1901605 72 0.014
purine nucleoside triphosphate metabolic process GO:0009144 412 0.014
anatomical structure formation involved in morphogenesis GO:0048646 284 0.014
regulation of antimicrobial humoral response GO:0002759 1 0.014
regulation of cell motility GO:2000145 299 0.014
immune system development GO:0002520 195 0.014
protein secretion GO:0009306 98 0.014
response to radiation GO:0009314 151 0.014
immune response activating signal transduction GO:0002757 90 0.014
maintenance of location in cell GO:0051651 62 0.014
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.014
organic acid transport GO:0015849 65 0.014
positive regulation of organelle organization GO:0010638 195 0.014
regulation of gtpase activity GO:0043087 180 0.014
positive regulation of humoral immune response GO:0002922 3 0.014
regulation of cd4 positive alpha beta t cell differentiation GO:0043370 3 0.014
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.014
organelle fission GO:0048285 149 0.014
Human
regulation of circadian sleep wake cycle sleep GO:0045187 2 0.014
tissue morphogenesis GO:0048729 96 0.014
Rat
positive regulation of innate immune response GO:0045089 79 0.014
embryonic placenta development GO:0001892 1 0.014
positive regulation of gtp catabolic process GO:0033126 166 0.014
icosanoid metabolic process GO:0006690 35 0.014
monovalent inorganic cation transport GO:0015672 128 0.014
organic hydroxy compound biosynthetic process GO:1901617 71 0.014
ion transmembrane transport GO:0034220 338 0.014
regulation of mitotic cell cycle GO:0007346 189 0.014
regulation of cell differentiation GO:0045595 393 0.014
positive regulation of cell differentiation GO:0045597 211 0.014
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.014
astrocyte differentiation GO:0048708 4 0.014
immune effector process GO:0002252 159 0.014
regulation of response to external stimulus GO:0032101 222 0.013
cellular response to lipopolysaccharide GO:0071222 57 0.013
endosomal transport GO:0016197 129 0.013
positive regulation of nucleoside metabolic process GO:0045979 186 0.013
cellular response to organic cyclic compound GO:0071407 127 0.013
positive regulation of antimicrobial humoral response GO:0002760 1 0.013
regulation of small gtpase mediated signal transduction GO:0051056 156 0.013
hormone transport GO:0009914 68 0.013
organ morphogenesis GO:0009887 147 0.013
Rat
chromosome passenger complex localization to spindle midzone GO:0035853 1 0.013
negative regulation of protein processing GO:0010955 142 0.013
regulation of immune effector process GO:0002697 91 0.013
neural tube closure GO:0001843 3 0.013
retrograde transport endosome to golgi GO:0042147 45 0.013
cell adhesion GO:0007155 325 0.013
positive regulation of intracellular protein transport GO:0090316 76 0.013
establishment of protein localization to membrane GO:0090150 121 0.013
cation transmembrane transport GO:0098655 238 0.013
response to growth factor GO:0070848 205 0.013
ossification GO:0001503 121 0.013
calcium ion transmembrane transport GO:0070588 76 0.013
regulation of cellular component biogenesis GO:0044087 281 0.013
negative regulation of embryonic development GO:0045992 4 0.013
multi organism cellular process GO:0044764 156 0.013
organelle assembly GO:0070925 176 0.013
reactive nitrogen species metabolic process GO:2001057 3 0.013
protein targeting to membrane GO:0006612 42 0.013
negative regulation of protein import into nucleus GO:0042308 30 0.013
regulation of transcription factor import into nucleus GO:0042990 39 0.013
organic hydroxy compound metabolic process GO:1901615 147 0.013
regulation of cytokine secretion GO:0050707 57 0.013
cell morphogenesis GO:0000902 296 0.013
regulation of cysteine type endopeptidase activity GO:2000116 127 0.013
dephosphorylation GO:0016311 209 0.012
carbohydrate metabolic process GO:0005975 207 0.012
Mouse
axis elongation GO:0003401 4 0.012
negative regulation of peptidase activity GO:0010466 91 0.012
myosin filament assembly GO:0031034 2 0.012
guanosine containing compound catabolic process GO:1901069 239 0.012
oocyte maturation GO:0001556 1 0.012
negative regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043154 46 0.012
blastoderm segmentation GO:0007350 2 0.012
muscle contraction GO:0006936 73 0.012
regulation of neuron migration GO:2001222 3 0.012
t cell activation GO:0042110 99 0.012
cellular component morphogenesis GO:0032989 314 0.012
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.012
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 2 0.012
cd4 positive alpha beta t cell differentiation involved in immune response GO:0002294 4 0.012
negative regulation of cytokine production GO:0001818 82 0.012
negative regulation of cysteine type endopeptidase activity GO:2000117 48 0.012
endocytosis GO:0006897 159 0.012
reactive oxygen species metabolic process GO:0072593 75 0.012
protein import into nucleus GO:0006606 104 0.012
regulation of hormone levels GO:0010817 125 0.012
regulation of cell maturation GO:1903429 3 0.012
regulation of interleukin 8 production GO:0032677 49 0.012
negative regulation of protein serine threonine kinase activity GO:0071901 57 0.012
positive regulation of cellular component organization GO:0051130 376 0.012
signal transduction in response to dna damage GO:0042770 57 0.012
positive regulation of cell cycle process GO:0090068 106 0.012
protein deacylation GO:0035601 39 0.012
stress activated protein kinase signaling cascade GO:0031098 94 0.012
fatty acid metabolic process GO:0006631 115 0.012
positive regulation of interleukin 5 production GO:0032754 3 0.012
long term memory GO:0007616 2 0.012
regulation of chromosome organization GO:0033044 103 0.012
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.012
proteasomal protein catabolic process GO:0010498 176 0.012
carbohydrate derivative biosynthetic process GO:1901137 207 0.012
Mouse
regulation of chromatin modification GO:1903308 51 0.012
negative regulation of protein kinase activity GO:0006469 98 0.012
regulation of macrophage derived foam cell differentiation GO:0010743 14 0.012
meiotic chromosome segregation GO:0045132 4 0.012
regulation of phosphatase activity GO:0010921 81 0.011
alcohol metabolic process GO:0006066 114 0.011
hemopoiesis GO:0030097 180 0.011
establishment of planar polarity GO:0001736 3 0.011
membrane hyperpolarization GO:0060081 1 0.011
limbic system development GO:0021761 3 0.011
cytokine secretion GO:0050663 64 0.011
regulation of protein localization to nucleus GO:1900180 85 0.011
jak stat cascade GO:0007259 46 0.011
positive regulation of cellular component biogenesis GO:0044089 158 0.011
positive regulation of secretion GO:0051047 116 0.011
protein k48 linked ubiquitination GO:0070936 38 0.011
regulation of histone modification GO:0031056 47 0.011
response to virus GO:0009615 126 0.011
nucleoside catabolic process GO:0009164 408 0.011
negative regulation of protein transport GO:0051224 75 0.011
positive regulation of meiotic cell cycle GO:0051446 2 0.011
regulation of dna replication GO:0006275 68 0.011
sulfur compound metabolic process GO:0006790 101 0.011
organophosphate biosynthetic process GO:0090407 163 0.011
peptidyl lysine monomethylation GO:0018026 4 0.011
peptidyl lysine methylation GO:0018022 37 0.011
activation of innate immune response GO:0002218 55 0.011
cellular macromolecular complex assembly GO:0034622 324 0.011
positive regulation of cell adhesion GO:0045785 84 0.011
cell part morphogenesis GO:0032990 137 0.011
interleukin 13 secretion GO:0072611 2 0.011
anterior posterior axis specification embryo GO:0008595 2 0.011
negative regulation of cytoplasmic transport GO:1903650 46 0.011
nucleoside monophosphate catabolic process GO:0009125 159 0.011
positive regulation of interleukin 13 production GO:0032736 4 0.011
peptide metabolic process GO:0006518 51 0.011
neurological system process GO:0050877 163 0.011
regulation of neuronal synaptic plasticity GO:0048168 1 0.011
viral life cycle GO:0019058 132 0.011
blood vessel morphogenesis GO:0048514 162 0.011
negative regulation of lipid storage GO:0010888 11 0.011
dna replication GO:0006260 116 0.011
nucleotide binding oligomerization domain containing 2 signaling pathway GO:0070431 4 0.011
positive regulation of intracellular transport GO:0032388 104 0.011
cellular response to lipid GO:0071396 127 0.011

SIRT6 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.025
sensory system disease DOID:0050155 203 0.021
nervous system disease DOID:863 431 0.021
central nervous system disease DOID:331 186 0.015
cancer DOID:162 167 0.013
disease of cellular proliferation DOID:14566 174 0.013
organ system cancer DOID:0050686 164 0.012
immune system disease DOID:2914 155 0.012
inherited metabolic disorder DOID:655 242 0.011
primary immunodeficiency disease DOID:612 36 0.011