Homo sapiens

72 known processes

TIMELESS

timeless homolog (Drosophila)

(Aliases: FLJ12640,TIM1,hTIM,FLJ20714,TIM)

TIMELESS biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
dna repair GO:0006281 198 0.423
cellular response to dna damage stimulus GO:0006974 379 0.409
Mouse
mitotic cell cycle phase transition GO:0044772 162 0.361
mitotic cell cycle GO:0000278 326 0.345
Worm
negative regulation of cell cycle GO:0045786 193 0.328
cell cycle phase transition GO:0044770 173 0.240
regulation of cell cycle GO:0051726 393 0.232
Worm
cell cycle g2 m phase transition GO:0044839 43 0.222
positive regulation of cell proliferation GO:0008284 301 0.197
regulation of cell cycle phase transition GO:1901987 126 0.183
negative regulation of cell cycle phase transition GO:1901988 89 0.165
regulation of mitotic cell cycle GO:0007346 189 0.147
microtubule based process GO:0007017 210 0.146
mitotic cell cycle checkpoint GO:0007093 68 0.143
g2 m transition of mitotic cell cycle GO:0000086 41 0.138
mitotic cell cycle process GO:1903047 286 0.129
Worm
negative regulation of mitotic cell cycle GO:0045930 102 0.119
regulation of cell cycle process GO:0010564 266 0.116
Worm
negative regulation of cell cycle process GO:0010948 121 0.115
response to uv GO:0009411 73 0.110
centrosome organization GO:0051297 58 0.110
cellular amino acid metabolic process GO:0006520 116 0.108
regulation of g2 m transition of mitotic cell cycle GO:0010389 20 0.099
microtubule cytoskeleton organization GO:0000226 176 0.096
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.096
double strand break repair GO:0006302 101 0.093
response to radiation GO:0009314 151 0.090
base excision repair GO:0006284 21 0.089
dna biosynthetic process GO:0071897 40 0.089
multicellular organismal aging GO:0010259 3 0.085
membrane organization GO:0061024 292 0.081
response to abiotic stimulus GO:0009628 336 0.080
regulation of cellular amine metabolic process GO:0033238 11 0.077
regulation of double strand break repair GO:2000779 22 0.077
dna dependent dna replication GO:0006261 44 0.076
ribonucleoside triphosphate metabolic process GO:0009199 412 0.071
regulation of cellular amino acid metabolic process GO:0006521 6 0.068
nucleoside triphosphate metabolic process GO:0009141 422 0.066
histone threonine phosphorylation GO:0035405 7 0.066
mitotic dna integrity checkpoint GO:0044774 30 0.065
organophosphate catabolic process GO:0046434 430 0.065
regulation of cytoskeleton organization GO:0051493 177 0.064
determination of adult lifespan GO:0008340 2 0.064
cellular amine metabolic process GO:0044106 41 0.063
cell cycle checkpoint GO:0000075 117 0.062
cellular ketone metabolic process GO:0042180 80 0.061
regulation of cellular ketone metabolic process GO:0010565 50 0.061
amine metabolic process GO:0009308 44 0.056
mitotic dna replication checkpoint GO:0033314 2 0.056
ribonucleoside monophosphate metabolic process GO:0009161 187 0.054
regulation of dna repair GO:0006282 47 0.054
vesicle mediated transport GO:0016192 371 0.052
mitotic dna damage checkpoint GO:0044773 28 0.052
endomembrane system organization GO:0010256 196 0.051
anatomical structure formation involved in morphogenesis GO:0048646 284 0.047
purine nucleoside triphosphate metabolic process GO:0009144 412 0.046
regulation of meiotic cell cycle GO:0051445 4 0.044
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.043
regulation of cell cycle g2 m phase transition GO:1902749 22 0.043
post embryonic development GO:0009791 2 0.042
cellular component morphogenesis GO:0032989 314 0.042
regulation of mitotic cell cycle phase transition GO:1901990 118 0.042
dna damage checkpoint GO:0000077 68 0.041
organelle fission GO:0048285 149 0.041
Worm
glycosyl compound catabolic process GO:1901658 413 0.041
regulation of microtubule based process GO:0032886 74 0.040
immune system development GO:0002520 195 0.040
regulation of protein localization GO:0032880 296 0.040
negative regulation of cell size GO:0045792 3 0.039
single organism membrane organization GO:0044802 268 0.039
positive regulation of protein kinase activity GO:0045860 190 0.039
cell division GO:0051301 168 0.038
nucleoside phosphate catabolic process GO:1901292 412 0.038
alpha amino acid metabolic process GO:1901605 72 0.038
photoreceptor cell differentiation GO:0046530 2 0.038
nucleoside monophosphate metabolic process GO:0009123 191 0.037
nucleotide catabolic process GO:0009166 408 0.037
dna recombination GO:0006310 77 0.037
double strand break repair via homologous recombination GO:0000724 50 0.037
purine ribonucleoside metabolic process GO:0046128 437 0.037
regulation of double strand break repair via homologous recombination GO:0010569 11 0.037
nucleotide biosynthetic process GO:0009165 109 0.036
cellular response to endogenous stimulus GO:0071495 336 0.036
response to nitrogen compound GO:1901698 184 0.035
response to organonitrogen compound GO:0010243 156 0.035
carbohydrate derivative biosynthetic process GO:1901137 207 0.035
endocytosis GO:0006897 159 0.035
purine nucleoside catabolic process GO:0006152 398 0.035
response to light stimulus GO:0009416 87 0.034
response to organic cyclic compound GO:0014070 204 0.033
organonitrogen compound biosynthetic process GO:1901566 200 0.032
mitotic sister chromatid segregation GO:0000070 53 0.032
Worm
protein localization to organelle GO:0033365 280 0.032
microtubule organizing center organization GO:0031023 62 0.031
dna integrity checkpoint GO:0031570 71 0.031
methylation GO:0032259 106 0.031
maintenance of location in cell GO:0051651 62 0.030
cellular response to organonitrogen compound GO:0071417 124 0.030
peptidyl serine phosphorylation GO:0018105 101 0.030
purine ribonucleoside catabolic process GO:0046130 398 0.030
protein modification by small protein conjugation GO:0032446 342 0.030
chromatin organization GO:0006325 351 0.030
purine containing compound catabolic process GO:0072523 411 0.030
regulation of protein kinase activity GO:0045859 289 0.029
cellular response to abiotic stimulus GO:0071214 117 0.029
protein acylation GO:0043543 138 0.029
nucleoside monophosphate catabolic process GO:0009125 159 0.029
regulation of kinase activity GO:0043549 314 0.029
regulation of cellular response to stress GO:0080135 244 0.028
nervous system development GO:0007399 293 0.028
response to caffeine GO:0031000 3 0.028
maintenance of location GO:0051235 112 0.028
nuclear division GO:0000280 128 0.028
Worm
positive regulation of cell cycle process GO:0090068 106 0.027
purine nucleotide catabolic process GO:0006195 405 0.027
cellular response to radiation GO:0071478 65 0.027
protein catabolic process GO:0030163 325 0.027
positive regulation of kinase activity GO:0033674 204 0.027
negative regulation of cellular protein metabolic process GO:0032269 353 0.026
regulation of dna metabolic process GO:0051052 153 0.026
ribonucleoside triphosphate catabolic process GO:0009203 391 0.026
nucleoside catabolic process GO:0009164 408 0.026
non recombinational repair GO:0000726 14 0.026
negative regulation of protein metabolic process GO:0051248 391 0.026
purine nucleoside triphosphate catabolic process GO:0009146 392 0.026
positive regulation of organelle organization GO:0010638 195 0.026
positive regulation of cellular component organization GO:0051130 376 0.025
negative regulation of g2 m transition of mitotic cell cycle GO:0010972 9 0.025
positive regulation of developmental process GO:0051094 314 0.025
actin filament based process GO:0030029 224 0.025
internal peptidyl lysine acetylation GO:0018393 97 0.024
nucleus organization GO:0006997 28 0.024
purine ribonucleotide catabolic process GO:0009154 404 0.024
activation of protein kinase activity GO:0032147 90 0.024
negative regulation of cellular component organization GO:0051129 235 0.024
blastocyst development GO:0001824 3 0.024
regulation of microtubule cytoskeleton organization GO:0070507 61 0.024
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.024
organelle assembly GO:0070925 176 0.024
negative regulation of organelle organization GO:0010639 126 0.024
purine nucleoside monophosphate catabolic process GO:0009128 158 0.024
protein alkylation GO:0008213 74 0.024
nuclear migration GO:0007097 1 0.023
negative regulation of cell cycle g2 m phase transition GO:1902750 10 0.023
intra s dna damage checkpoint GO:0031573 4 0.023
positive regulation of hydrolase activity GO:0051345 331 0.023
viral life cycle GO:0019058 132 0.023
cellular response to external stimulus GO:0071496 111 0.022
meiosis i GO:0007127 4 0.022
cellular component disassembly GO:0022411 92 0.022
organ morphogenesis GO:0009887 147 0.022
histone acetylation GO:0016573 93 0.021
embryo development GO:0009790 123 0.021
Mouse Worm
cellular macromolecule catabolic process GO:0044265 380 0.021
chromatin modification GO:0016568 298 0.021
ribonucleotide catabolic process GO:0009261 405 0.021
cell development GO:0048468 328 0.021
cytoplasmic transport GO:0016482 379 0.021
negative regulation of phosphate metabolic process GO:0045936 267 0.021
intracellular protein transport GO:0006886 270 0.020
positive regulation of mitotic cell cycle GO:0045931 60 0.020
coenzyme metabolic process GO:0006732 65 0.020
positive regulation of phosphorylation GO:0042327 394 0.020
regulation of protein serine threonine kinase activity GO:0071900 179 0.020
positive regulation of immune system process GO:0002684 283 0.020
mitotic nuclear division GO:0007067 119 0.020
Worm
lagging strand elongation GO:0006273 3 0.019
cofactor metabolic process GO:0051186 87 0.019
macromolecule methylation GO:0043414 97 0.019
digestive tract development GO:0048565 75 0.019
cell morphogenesis GO:0000902 296 0.019
atp metabolic process GO:0046034 176 0.019
cellular response to uv GO:0034644 32 0.019
response to oxygen containing compound GO:1901700 369 0.019
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.019
ras protein signal transduction GO:0007265 73 0.019
cellular response to organic cyclic compound GO:0071407 127 0.019
cell activation GO:0001775 213 0.018
regulation of response to dna damage stimulus GO:2001020 94 0.018
cellular response to nitrogen compound GO:1901699 144 0.018
ribonucleoside catabolic process GO:0042454 406 0.018
cellular protein complex assembly GO:0043623 188 0.018
dephosphorylation GO:0016311 209 0.018
neuromuscular junction development GO:0007528 3 0.018
regulation of cell diameter GO:0060305 1 0.018
lipid metabolic process GO:0006629 381 0.018
immune response GO:0006955 307 0.018
regulation of cellular component movement GO:0051270 334 0.017
response to external biotic stimulus GO:0043207 261 0.017
positive regulation of catabolic process GO:0009896 310 0.017
cellular macromolecular complex assembly GO:0034622 324 0.017
microtubule anchoring GO:0034453 24 0.017
response to inorganic substance GO:0010035 127 0.017
positive regulation of transferase activity GO:0051347 227 0.017
peptidyl lysine modification GO:0018205 144 0.017
immune effector process GO:0002252 159 0.017
dna replication GO:0006260 116 0.017
lymphocyte activation GO:0046649 133 0.017
single organism cellular localization GO:1902580 332 0.017
purine nucleoside monophosphate metabolic process GO:0009126 186 0.016
response to purine containing compound GO:0014074 40 0.016
regulation of chromatin organization GO:1902275 56 0.016
positive regulation of protein phosphorylation GO:0001934 313 0.016
sex determination GO:0007530 3 0.016
cell projection assembly GO:0030031 126 0.016
reproduction GO:0000003 63 0.016
Worm
guanosine containing compound catabolic process GO:1901069 239 0.016
enzyme linked receptor protein signaling pathway GO:0007167 303 0.016
spermatid differentiation GO:0048515 4 0.016
organophosphate biosynthetic process GO:0090407 163 0.016
protein localization to nucleus GO:0034504 136 0.016
maintenance of protein location in cell GO:0032507 56 0.016
positive regulation of cellular amine metabolic process GO:0033240 7 0.015
myosin filament assembly GO:0031034 2 0.015
covalent chromatin modification GO:0016569 254 0.015
cellular modified amino acid metabolic process GO:0006575 64 0.015
response to other organism GO:0051707 261 0.015
chemical homeostasis GO:0048878 306 0.015
cell projection organization GO:0030030 252 0.015
histone lysine methylation GO:0034968 50 0.015
internal protein amino acid acetylation GO:0006475 101 0.015
male meiosis GO:0007140 1 0.015
cell cycle arrest GO:0007050 71 0.015
spermatid development GO:0007286 4 0.015
golgi organization GO:0007030 38 0.015
dna replication checkpoint GO:0000076 5 0.014
regulation of chromosome segregation GO:0051983 44 0.014
Worm
negative regulation of cell death GO:0060548 345 0.014
double strand break repair via nonhomologous end joining GO:0006303 10 0.014
neurogenesis GO:0022008 169 0.014
chromatin remodeling GO:0006338 55 0.014
tube morphogenesis GO:0035239 95 0.014
Mouse
spindle organization GO:0007051 53 0.014
negative regulation of intracellular signal transduction GO:1902532 183 0.014
protein acetylation GO:0006473 116 0.014
positive regulation of cellular catabolic process GO:0031331 284 0.014
postreplication repair GO:0006301 12 0.014
nucleoside triphosphate catabolic process GO:0009143 394 0.014
response to metal ion GO:0010038 84 0.013
cell cycle g1 s phase transition GO:0044843 80 0.013
negative regulation of apoptotic process GO:0043066 316 0.013
regulation of nucleoside metabolic process GO:0009118 209 0.013
peptidyl serine modification GO:0018209 106 0.013
response to drug GO:0042493 81 0.013
response to growth factor GO:0070848 205 0.013
negative regulation of phosphorus metabolic process GO:0010563 267 0.013
cellular response to light stimulus GO:0071482 34 0.013
peptidyl lysine acetylation GO:0018394 101 0.013
cerebellum development GO:0021549 2 0.013
regulation of gene expression epigenetic GO:0040029 73 0.013
interspecies interaction between organisms GO:0044419 156 0.013
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.013
protein targeting GO:0006605 187 0.013
defense response GO:0006952 315 0.013
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.013
dna conformation change GO:0071103 113 0.013
digestive system development GO:0055123 75 0.012
regulation of transferase activity GO:0051338 355 0.012
regulation of nucleotide catabolic process GO:0030811 205 0.012
recombinational repair GO:0000725 50 0.012
response to cytokine GO:0034097 232 0.012
cell part morphogenesis GO:0032990 137 0.012
positive regulation of immune response GO:0050778 159 0.012
adult locomotory behavior GO:0008344 1 0.012
regulation of mapk cascade GO:0043408 262 0.012
cell adhesion GO:0007155 325 0.012
histone modification GO:0016570 251 0.012
hemopoiesis GO:0030097 180 0.012
tube development GO:0035295 125 0.012
Mouse
cell fate determination GO:0001709 3 0.012
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.012
biological adhesion GO:0022610 331 0.012
mapk cascade GO:0000165 288 0.012
cell cell signaling GO:0007267 155 0.012
cellular protein catabolic process GO:0044257 261 0.012
digestive tract morphogenesis GO:0048546 56 0.012
regulation of purine nucleotide metabolic process GO:1900542 264 0.012
regulation of purine nucleotide catabolic process GO:0033121 205 0.012
regulation of immune response GO:0050776 201 0.012
centrosome separation GO:0051299 3 0.012
dna synthesis involved in dna repair GO:0000731 6 0.012
rna catabolic process GO:0006401 71 0.011
regulation of protein catabolic process GO:0042176 155 0.011
oocyte differentiation GO:0009994 2 0.011
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 17 0.011
small gtpase mediated signal transduction GO:0007264 78 0.011
regulation of chromosome organization GO:0033044 103 0.011
Worm
regulation of ras protein signal transduction GO:0046578 155 0.011
protein oligomerization GO:0051259 173 0.011
regulation of histone modification GO:0031056 47 0.011
negative regulation of protein phosphorylation GO:0001933 140 0.011
reciprocal dna recombination GO:0035825 4 0.011
viral process GO:0016032 146 0.011
regulation of leukocyte activation GO:0002694 115 0.011
oxidation reduction process GO:0055114 396 0.011
response to mechanical stimulus GO:0009612 51 0.011
maintenance of protein location GO:0045185 57 0.011
protein autophosphorylation GO:0046777 123 0.011
cellular response to oxygen containing compound GO:1901701 276 0.011
positive regulation of cytokinesis GO:0032467 29 0.011
cellular response to purine containing compound GO:0071415 3 0.011
small molecule catabolic process GO:0044282 92 0.011
regulation of neural precursor cell proliferation GO:2000177 4 0.011
regulation of lymphocyte activation GO:0051249 103 0.011
actin cytoskeleton organization GO:0030036 207 0.011
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.011
female gamete generation GO:0007292 2 0.011
ribonucleoside monophosphate catabolic process GO:0009158 158 0.011
apoptotic signaling pathway GO:0097190 268 0.011
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.011
locomotory behavior GO:0007626 1 0.011
receptor mediated endocytosis GO:0006898 84 0.010
regulation of peptidyl lysine acetylation GO:2000756 22 0.010
regulation of binding GO:0051098 111 0.010
embryonic morphogenesis GO:0048598 85 0.010
positive regulation of leukocyte activation GO:0002696 80 0.010
negative regulation of catalytic activity GO:0043086 335 0.010
response to oxidative stress GO:0006979 121 0.010
growth GO:0040007 202 0.010
regulation of cell division GO:0051302 116 0.010
leukocyte activation GO:0045321 164 0.010
cellular lipid metabolic process GO:0044255 303 0.010
regulation of cell activation GO:0050865 125 0.010
signal transduction by phosphorylation GO:0023014 297 0.010
positive regulation of nucleoside metabolic process GO:0045979 186 0.010
negative regulation of protein modification process GO:0031400 200 0.010
generation of neurons GO:0048699 152 0.010

TIMELESS disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.045
disease of cellular proliferation DOID:14566 174 0.031
cancer DOID:162 167 0.019
inherited metabolic disorder DOID:655 242 0.016
organ system cancer DOID:0050686 164 0.014
gastrointestinal system cancer DOID:3119 52 0.012
musculoskeletal system disease DOID:17 223 0.010