|
|
regulation of activin receptor signaling pathway
|
GO:0032925 |
14 |
0.980
|
|
|
|
activin receptor signaling pathway
|
GO:0032924 |
24 |
0.836
|
|
|
|
transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0007178 |
125 |
0.776
|
|
|
|
cation transmembrane transport
|
GO:0098655 |
238 |
0.702
|
|
|
|
negative regulation of transport
|
GO:0051051 |
176 |
0.679
|
|
|
|
cation transport
|
GO:0006812 |
331 |
0.656
|
|
|
|
inorganic ion transmembrane transport
|
GO:0098660 |
231 |
0.654
|
|
|
|
smad protein complex assembly
|
GO:0007183 |
12 |
0.584
|
|
|
|
cellular divalent inorganic cation homeostasis
|
GO:0072503 |
128 |
0.569
|
|
|
|
system process
|
GO:0003008 |
349 |
0.559
|
Human |
|
|
enzyme linked receptor protein signaling pathway
|
GO:0007167 |
303 |
0.556
|
|
|
|
ion transmembrane transport
|
GO:0034220 |
338 |
0.543
|
|
|
|
inorganic cation transmembrane transport
|
GO:0098662 |
194 |
0.532
|
|
|
|
response to caffeine
|
GO:0031000 |
3 |
0.522
|
|
|
|
divalent inorganic cation homeostasis
|
GO:0072507 |
136 |
0.519
|
|
|
|
positive regulation of homeostatic process
|
GO:0032846 |
47 |
0.508
|
|
|
|
immune response
|
GO:0006955 |
307 |
0.474
|
Human Worm |
|
|
transmembrane transport
|
GO:0055085 |
399 |
0.468
|
|
|
|
metal ion transport
|
GO:0030001 |
272 |
0.467
|
|
|
|
positive regulation of cytosolic calcium ion concentration
|
GO:0007204 |
82 |
0.467
|
|
|
|
metal ion homeostasis
|
GO:0055065 |
169 |
0.465
|
|
|
|
anatomical structure formation involved in morphogenesis
|
GO:0048646 |
284 |
0.463
|
Human Zebrafish |
|
|
positive regulation of pathway restricted smad protein phosphorylation
|
GO:0010862 |
22 |
0.450
|
Human Rat Fly |
|
|
protein ubiquitination
|
GO:0016567 |
314 |
0.449
|
Human |
|
|
chemical homeostasis
|
GO:0048878 |
306 |
0.447
|
|
|
|
positive regulation of i kappab kinase nf kappab signaling
|
GO:0043123 |
132 |
0.447
|
|
|
|
cytokine mediated signaling pathway
|
GO:0019221 |
109 |
0.410
|
|
|
|
regulation of i kappab kinase nf kappab signaling
|
GO:0043122 |
162 |
0.404
|
|
|
|
calcium ion homeostasis
|
GO:0055074 |
122 |
0.395
|
|
|
|
muscle organ morphogenesis
|
GO:0048644 |
19 |
0.390
|
|
|
|
ventricular cardiac muscle tissue development
|
GO:0003229 |
14 |
0.389
|
|
|
|
cardiac muscle tissue development
|
GO:0048738 |
39 |
0.385
|
Human |
|
|
regulation of metal ion transport
|
GO:0010959 |
120 |
0.381
|
|
|
|
regulation of immune response
|
GO:0050776 |
201 |
0.372
|
|
|
|
muscle contraction
|
GO:0006936 |
73 |
0.371
|
|
|
|
ion homeostasis
|
GO:0050801 |
230 |
0.369
|
|
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
313 |
0.368
|
Human Rat Fly |
|
|
divalent inorganic cation transport
|
GO:0072511 |
158 |
0.362
|
|
|
|
cellular ion homeostasis
|
GO:0006873 |
168 |
0.355
|
|
|
|
regulation of protein ubiquitination
|
GO:0031396 |
95 |
0.348
|
Human |
|
|
regulation of protein kinase activity
|
GO:0045859 |
289 |
0.344
|
Human |
|
|
response to organonitrogen compound
|
GO:0010243 |
156 |
0.327
|
|
|
|
regulation of calcium ion transmembrane transporter activity
|
GO:1901019 |
28 |
0.326
|
|
|
|
cardiac chamber morphogenesis
|
GO:0003206 |
26 |
0.324
|
Human |
|
|
calcium ion transmembrane transport
|
GO:0070588 |
76 |
0.322
|
|
|
|
organ morphogenesis
|
GO:0009887 |
147 |
0.318
|
Human Fly |
|
|
cellular homeostasis
|
GO:0019725 |
196 |
0.313
|
|
|
|
amyloid precursor protein catabolic process
|
GO:0042987 |
12 |
0.310
|
|
|
|
regulation of transporter activity
|
GO:0032409 |
82 |
0.305
|
|
|
|
cardiac ventricle morphogenesis
|
GO:0003208 |
20 |
0.305
|
|
|
|
regulation of calcium ion transport
|
GO:0051924 |
79 |
0.303
|
|
|
|
cation homeostasis
|
GO:0055080 |
189 |
0.303
|
|
|
|
regulation of pathway restricted smad protein phosphorylation
|
GO:0060393 |
34 |
0.298
|
Human Rat Fly |
|
|
mononuclear cell proliferation
|
GO:0032943 |
71 |
0.295
|
|
|
|
cellular response to endogenous stimulus
|
GO:0071495 |
336 |
0.293
|
Human |
|
|
cellular cation homeostasis
|
GO:0030003 |
163 |
0.292
|
|
|
|
i kappab kinase nf kappab signaling
|
GO:0007249 |
166 |
0.291
|
|
|
|
regulation of transmembrane transport
|
GO:0034762 |
139 |
0.288
|
|
|
|
dephosphorylation
|
GO:0016311 |
209 |
0.277
|
|
|
|
calcium ion transport
|
GO:0006816 |
147 |
0.272
|
|
|
|
regulation of ion transport
|
GO:0043269 |
189 |
0.252
|
|
|
|
regulation of locomotion
|
GO:0040012 |
329 |
0.252
|
|
|
|
nervous system development
|
GO:0007399 |
293 |
0.251
|
Rat Fly |
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.251
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
11 |
0.250
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.249
|
Human |
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
267 |
0.249
|
|
|
|
cellular chemical homeostasis
|
GO:0055082 |
180 |
0.247
|
|
|
|
tissue morphogenesis
|
GO:0048729 |
96 |
0.246
|
Human Zebrafish |
|
|
cellular calcium ion homeostasis
|
GO:0006874 |
117 |
0.238
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.238
|
|
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.238
|
Human |
|
|
regulation of cytoplasmic transport
|
GO:1903649 |
149 |
0.235
|
Human |
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
6 |
0.235
|
|
|
|
regulation of calcium ion transport into cytosol
|
GO:0010522 |
33 |
0.233
|
|
|
|
cardiac chamber development
|
GO:0003205 |
30 |
0.233
|
Human |
|
|
response to cytokine
|
GO:0034097 |
232 |
0.230
|
|
|
|
regulation of intracellular transport
|
GO:0032386 |
195 |
0.229
|
Human |
|
|
cellular amine metabolic process
|
GO:0044106 |
41 |
0.220
|
|
|
|
cellular metal ion homeostasis
|
GO:0006875 |
146 |
0.218
|
|
|
|
negative regulation of transporter activity
|
GO:0032410 |
25 |
0.218
|
|
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.217
|
|
|
|
regulation of cell differentiation
|
GO:0045595 |
393 |
0.214
|
|
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
391 |
0.212
|
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
249 |
0.206
|
Human |
|
|
cardiac muscle tissue morphogenesis
|
GO:0055008 |
18 |
0.206
|
|
|
|
sequestering of metal ion
|
GO:0051238 |
24 |
0.205
|
|
|
|
regulation of ryanodine sensitive calcium release channel activity
|
GO:0060314 |
12 |
0.204
|
|
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
331 |
0.203
|
Human |
|
|
peptidyl proline modification
|
GO:0018208 |
15 |
0.201
|
|
|
|
response to redox state
|
GO:0051775 |
7 |
0.201
|
|
|
|
cytoplasmic transport
|
GO:0016482 |
379 |
0.198
|
Human |
|
|
regulation of amyloid precursor protein catabolic process
|
GO:1902991 |
9 |
0.198
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.198
|
Human |
|
|
cellular ketone metabolic process
|
GO:0042180 |
80 |
0.194
|
|
|
|
trabecula morphogenesis
|
GO:0061383 |
2 |
0.193
|
|
|
|
sequestering of calcium ion
|
GO:0051208 |
17 |
0.192
|
|
|
|
cytosolic calcium ion homeostasis
|
GO:0051480 |
89 |
0.191
|
|
|
|
protein localization to organelle
|
GO:0033365 |
280 |
0.191
|
Human Worm |
|
|
hemopoiesis
|
GO:0030097 |
180 |
0.190
|
|
|
|
regulation of epithelial cell migration
|
GO:0010632 |
93 |
0.188
|
Human |
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
379 |
0.185
|
|
|
|
calcium ion transport into cytosol
|
GO:0060402 |
48 |
0.185
|
|
|
|
regulation of ion transmembrane transporter activity
|
GO:0032412 |
72 |
0.185
|
|
|
|
regulation of cell cycle
|
GO:0051726 |
393 |
0.183
|
Fly |
|
|
endoplasmic reticulum to cytosol transport
|
GO:1903513 |
13 |
0.182
|
|
|
|
positive regulation of cell differentiation
|
GO:0045597 |
211 |
0.177
|
|
|
|
regulation of cell motility
|
GO:2000145 |
299 |
0.175
|
|
|
|
negative regulation of homeostatic process
|
GO:0032845 |
59 |
0.172
|
|
|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.169
|
Human Rat Fly |
|
|
muscle tissue morphogenesis
|
GO:0060415 |
19 |
0.166
|
|
|
|
muscle structure development
|
GO:0061061 |
98 |
0.164
|
Human |
|
|
regulation of cation channel activity
|
GO:2001257 |
33 |
0.164
|
|
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.163
|
|
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.158
|
|
|
|
negative regulation of sequestering of calcium ion
|
GO:0051283 |
41 |
0.157
|
|
|
|
regulation of cell migration
|
GO:0030334 |
289 |
0.157
|
|
|
|
positive regulation of protein modification by small protein conjugation or removal
|
GO:1903322 |
61 |
0.156
|
|
|
|
circulatory system development
|
GO:0072359 |
262 |
0.152
|
Human |
|
|
cell adhesion
|
GO:0007155 |
325 |
0.151
|
Human Worm |
|
|
cellular response to cytokine stimulus
|
GO:0071345 |
181 |
0.150
|
|
|
|
cardiac ventricle development
|
GO:0003231 |
23 |
0.149
|
|
|
|
regulation of calcium ion transmembrane transport
|
GO:1903169 |
28 |
0.149
|
|
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.149
|
Human |
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
140 |
0.148
|
|
|
|
protein modification by small protein conjugation
|
GO:0032446 |
342 |
0.148
|
Human |
|
|
negative regulation of dephosphorylation
|
GO:0035305 |
63 |
0.147
|
|
|
|
response to growth factor
|
GO:0070848 |
205 |
0.147
|
Human |
|
|
positive regulation of kinase activity
|
GO:0033674 |
204 |
0.146
|
Human |
|
|
cell projection organization
|
GO:0030030 |
252 |
0.144
|
Fly |
|
|
negative regulation of ion transmembrane transport
|
GO:0034766 |
26 |
0.143
|
|
|
|
response to inorganic substance
|
GO:0010035 |
127 |
0.142
|
|
|
|
cellular macromolecular complex assembly
|
GO:0034622 |
324 |
0.142
|
|
|
|
response to nitrogen compound
|
GO:1901698 |
184 |
0.140
|
|
|
|
response to oxygen containing compound
|
GO:1901700 |
369 |
0.139
|
Human |
|
|
cellular lipid metabolic process
|
GO:0044255 |
303 |
0.139
|
|
|
|
response to purine containing compound
|
GO:0014074 |
40 |
0.137
|
|
|
|
ventricular cardiac muscle tissue morphogenesis
|
GO:0055010 |
14 |
0.137
|
|
|
|
negative regulation of cell proliferation
|
GO:0008285 |
228 |
0.137
|
Human |
|
|
cell morphogenesis
|
GO:0000902 |
296 |
0.136
|
Human Worm Fly |
|
|
response to metal ion
|
GO:0010038 |
84 |
0.134
|
|
|
|
ameboidal type cell migration
|
GO:0001667 |
135 |
0.133
|
|
|
|
response to biotic stimulus
|
GO:0009607 |
276 |
0.129
|
Worm |
|
|
muscle system process
|
GO:0003012 |
81 |
0.128
|
|
|
|
negative regulation of transmembrane transport
|
GO:0034763 |
29 |
0.127
|
|
|
|
negative regulation of hydrolase activity
|
GO:0051346 |
182 |
0.126
|
|
|
|
vasculature development
|
GO:0001944 |
181 |
0.125
|
Human |
|
|
leukocyte proliferation
|
GO:0070661 |
74 |
0.125
|
|
|
|
regulation of ion homeostasis
|
GO:2000021 |
73 |
0.125
|
|
|
|
digestive system development
|
GO:0055123 |
75 |
0.123
|
Zebrafish |
|
|
muscle organ development
|
GO:0007517 |
56 |
0.122
|
|
|
|
apoptotic signaling pathway
|
GO:0097190 |
268 |
0.121
|
|
|
|
regulation of protein modification by small protein conjugation or removal
|
GO:1903320 |
107 |
0.121
|
Human |
|
|
regulation of dephosphorylation
|
GO:0035303 |
96 |
0.120
|
|
|
|
regulation of protein transport
|
GO:0051223 |
213 |
0.120
|
Human |
|
|
negative regulation of transcription from rna polymerase ii promoter
|
GO:0000122 |
281 |
0.118
|
|
|
|
positive regulation of cellular component organization
|
GO:0051130 |
376 |
0.117
|
|
|
|
cell activation
|
GO:0001775 |
213 |
0.117
|
|
|
|
positive regulation of proteolysis
|
GO:0045862 |
142 |
0.117
|
Human |
|
|
cellular component morphogenesis
|
GO:0032989 |
314 |
0.117
|
Human Worm Fly |
|
|
regulation of mapk cascade
|
GO:0043408 |
262 |
0.117
|
Human |
|
|
sarcoplasmic reticulum calcium ion transport
|
GO:0070296 |
13 |
0.116
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.115
|
|
|
|
heart development
|
GO:0007507 |
95 |
0.113
|
Human |
|
|
regulation of phosphatase activity
|
GO:0010921 |
81 |
0.113
|
|
|
|
positive regulation of cell proliferation
|
GO:0008284 |
301 |
0.111
|
Human |
|
|
lymphocyte proliferation
|
GO:0046651 |
70 |
0.110
|
|
|
|
negative regulation of ion transport
|
GO:0043271 |
39 |
0.108
|
|
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
267 |
0.108
|
|
|
|
calcium ion transport from endoplasmic reticulum to cytosol
|
GO:1903514 |
13 |
0.107
|
|
|
|
defense response
|
GO:0006952 |
315 |
0.107
|
Worm |
|
|
positive regulation of cell death
|
GO:0010942 |
263 |
0.106
|
Human |
|
|
monocarboxylic acid metabolic process
|
GO:0032787 |
185 |
0.105
|
|
|
|
oogenesis
|
GO:0048477 |
2 |
0.105
|
|
|
|
tube development
|
GO:0035295 |
125 |
0.105
|
Human Zebrafish |
|
|
maintenance of location
|
GO:0051235 |
112 |
0.105
|
Worm |
|
|
protein catabolic process
|
GO:0030163 |
325 |
0.104
|
Worm |
|
|
actin filament based process
|
GO:0030029 |
224 |
0.104
|
|
|
|
regulation of cellular component movement
|
GO:0051270 |
334 |
0.103
|
|
|
|
positive regulation of transport
|
GO:0051050 |
336 |
0.102
|
Human |
|
|
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
|
GO:0014808 |
13 |
0.102
|
|
|
|
tissue migration
|
GO:0090130 |
119 |
0.101
|
Human |
|
|
taxis
|
GO:0042330 |
157 |
0.099
|
Fly |
|
|
negative regulation of calcium ion transport
|
GO:0051926 |
19 |
0.098
|
|
|
|
regulation of cell adhesion
|
GO:0030155 |
166 |
0.097
|
Human Worm |
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.097
|
Human |
|
|
negative regulation of intracellular transport
|
GO:0032387 |
60 |
0.095
|
|
|
|
response to lipid
|
GO:0033993 |
206 |
0.094
|
Human |
|
|
muscle tissue development
|
GO:0060537 |
62 |
0.094
|
Human |
|
|
neuron differentiation
|
GO:0030182 |
138 |
0.094
|
Fly |
|
|
post embryonic development
|
GO:0009791 |
2 |
0.093
|
Worm Fly |
|
|
locomotory behavior
|
GO:0007626 |
1 |
0.093
|
|
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.092
|
|
|
|
neuron projection development
|
GO:0031175 |
106 |
0.092
|
Fly |
|
|
lipid metabolic process
|
GO:0006629 |
381 |
0.091
|
|
|
|
regulation of sequestering of calcium ion
|
GO:0051282 |
41 |
0.091
|
|
|
|
determination of adult lifespan
|
GO:0008340 |
2 |
0.091
|
Fly |
|
|
mesenchyme development
|
GO:0060485 |
59 |
0.091
|
Human |
|
|
blood circulation
|
GO:0008015 |
113 |
0.090
|
Human |
|
|
regulation of binding
|
GO:0051098 |
111 |
0.090
|
|
|
|
endothelial cell proliferation
|
GO:0001935 |
65 |
0.090
|
Human |
|
|
positive regulation of mapk cascade
|
GO:0043410 |
190 |
0.089
|
Human |
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
7 |
0.089
|
|
|
|
interspecies interaction between organisms
|
GO:0044419 |
156 |
0.089
|
|
|
|
regulation of protein binding
|
GO:0043393 |
66 |
0.088
|
|
|
|
cardiovascular system development
|
GO:0072358 |
262 |
0.088
|
Human |
|
|
cellular protein complex assembly
|
GO:0043623 |
188 |
0.088
|
|
|
|
positive regulation of cell migration
|
GO:0030335 |
172 |
0.087
|
|
|
|
ras protein signal transduction
|
GO:0007265 |
73 |
0.087
|
|
|
|
positive regulation of binding
|
GO:0051099 |
45 |
0.086
|
|
|
|
positive regulation of protein ubiquitination
|
GO:0031398 |
53 |
0.085
|
|
|
|
regulation of proteolysis
|
GO:0030162 |
293 |
0.085
|
Human |
|
|
mitotic cell cycle
|
GO:0000278 |
326 |
0.085
|
|
|
|
digestive tract development
|
GO:0048565 |
75 |
0.084
|
Zebrafish |
|
|
regulation of growth
|
GO:0040008 |
165 |
0.084
|
|
|
|
immune system development
|
GO:0002520 |
195 |
0.084
|
|
|
|
vesicle mediated transport
|
GO:0016192 |
371 |
0.083
|
|
|
|
negative regulation of ion transmembrane transporter activity
|
GO:0032413 |
19 |
0.082
|
|
|
|
neural crest cell development
|
GO:0014032 |
3 |
0.082
|
|
|
|
negative regulation of protein modification process
|
GO:0031400 |
200 |
0.081
|
|
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
175 |
0.081
|
Human |
|
|
intracellular protein transport
|
GO:0006886 |
270 |
0.081
|
Human |
|
|
negative regulation of cytoplasmic transport
|
GO:1903650 |
46 |
0.081
|
|
|
|
neurogenesis
|
GO:0022008 |
169 |
0.081
|
Fly |
|
|
negative regulation of blood pressure
|
GO:0045776 |
3 |
0.080
|
Human |
|
|
regulation of multi organism process
|
GO:0043900 |
157 |
0.079
|
|
|
|
negative regulation of developmental process
|
GO:0051093 |
247 |
0.079
|
Human |
|
|
regulation of release of sequestered calcium ion into cytosol
|
GO:0051279 |
27 |
0.079
|
|
|
|
multicellular organismal aging
|
GO:0010259 |
3 |
0.079
|
Fly |
|
|
t cell proliferation
|
GO:0042098 |
45 |
0.078
|
|
|
|
mitotic cell cycle process
|
GO:1903047 |
286 |
0.077
|
|
|
|
cellular response to oxygen containing compound
|
GO:1901701 |
276 |
0.077
|
|
|
|
positive regulation of immune system process
|
GO:0002684 |
283 |
0.077
|
|
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
380 |
0.076
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
179 |
0.075
|
Human |
|
|
regulation of cysteine type endopeptidase activity
|
GO:2000116 |
127 |
0.075
|
Human |
|
|
regulation of establishment of protein localization
|
GO:0070201 |
242 |
0.075
|
Human |
|
|
skeletal system development
|
GO:0001501 |
79 |
0.075
|
Human |
|
|
response to abiotic stimulus
|
GO:0009628 |
336 |
0.074
|
Fly |
|
|
regulation of endothelial cell migration
|
GO:0010594 |
67 |
0.073
|
Human |
|
|
single organism carbohydrate metabolic process
|
GO:0044723 |
193 |
0.073
|
|
|
|
generation of neurons
|
GO:0048699 |
152 |
0.071
|
Fly |
|
|
regeneration
|
GO:0031099 |
4 |
0.070
|
Zebrafish |
|
|
organic acid biosynthetic process
|
GO:0016053 |
97 |
0.070
|
|
|
|
positive regulation of protein binding
|
GO:0032092 |
24 |
0.070
|
|
|
|
regulation of response to external stimulus
|
GO:0032101 |
222 |
0.070
|
|
|
|
t cell activation
|
GO:0042110 |
99 |
0.069
|
|
|
|
bmp signaling pathway
|
GO:0030509 |
49 |
0.069
|
Human Fly |
|
|
chromatin organization
|
GO:0006325 |
351 |
0.068
|
|
|
|
cell growth
|
GO:0016049 |
160 |
0.068
|
|
|
|
negative regulation of ryanodine sensitive calcium release channel activity
|
GO:0060315 |
6 |
0.068
|
|
|
|
nucleocytoplasmic transport
|
GO:0006913 |
176 |
0.068
|
Human |
|
|
response to transition metal nanoparticle
|
GO:1990267 |
29 |
0.067
|
|
|
|
trabecula formation
|
GO:0060343 |
1 |
0.066
|
|
|
|
negative regulation of programmed cell death
|
GO:0043069 |
321 |
0.066
|
Human |
|
|
divalent metal ion transport
|
GO:0070838 |
152 |
0.065
|
|
|
|
amyloid precursor protein metabolic process
|
GO:0042982 |
17 |
0.064
|
|
|
|
striated muscle tissue development
|
GO:0014706 |
59 |
0.064
|
Human |
|
|
negative regulation of phosphorylation
|
GO:0042326 |
174 |
0.063
|
|
|
|
negative regulation of epithelial cell migration
|
GO:0010633 |
38 |
0.063
|
Human |
|
|
secretion
|
GO:0046903 |
254 |
0.063
|
|
|
|
positive regulation of apoptotic process
|
GO:0043065 |
246 |
0.063
|
Human |
|
|
cell cycle phase transition
|
GO:0044770 |
173 |
0.062
|
|
|
|
negative regulation of epithelial cell proliferation
|
GO:0050680 |
48 |
0.062
|
|
|
|
lipid biosynthetic process
|
GO:0008610 |
177 |
0.062
|
|
|
|
carboxylic acid biosynthetic process
|
GO:0046394 |
97 |
0.061
|
|
|
|
negative regulation of cellular component organization
|
GO:0051129 |
235 |
0.061
|
Human |
|
|
peptidyl serine modification
|
GO:0018209 |
106 |
0.058
|
Human |
|
|
regulation of cell cycle process
|
GO:0010564 |
266 |
0.057
|
|
|
|
regulation of cellular response to growth factor stimulus
|
GO:0090287 |
76 |
0.056
|
|
|
|
multi organism cellular process
|
GO:0044764 |
156 |
0.056
|
|
|
|
immune effector process
|
GO:0002252 |
159 |
0.056
|
|
|
|
symbiosis encompassing mutualism through parasitism
|
GO:0044403 |
156 |
0.055
|
|
|
|
positive regulation of erythrocyte differentiation
|
GO:0045648 |
11 |
0.055
|
|
|
|
regulation of transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0090092 |
90 |
0.055
|
|
|
|
head development
|
GO:0060322 |
108 |
0.055
|
Fly |
|
|
regulation of lipid metabolic process
|
GO:0019216 |
96 |
0.055
|
|
|
|
autophagy
|
GO:0006914 |
88 |
0.054
|
Fly |
|
|
cellular protein catabolic process
|
GO:0044257 |
261 |
0.054
|
|
|
|
modification dependent macromolecule catabolic process
|
GO:0043632 |
212 |
0.053
|
|
|
|
negative regulation of locomotion
|
GO:0040013 |
118 |
0.053
|
Human |
|
|
cytosolic calcium ion transport
|
GO:0060401 |
48 |
0.053
|
|
|
|
positive regulation of catabolic process
|
GO:0009896 |
310 |
0.052
|
Worm |
|
|
midgut development
|
GO:0007494 |
1 |
0.052
|
|
|
|
organic hydroxy compound metabolic process
|
GO:1901615 |
147 |
0.052
|
|
|
|
monocarboxylic acid biosynthetic process
|
GO:0072330 |
67 |
0.052
|
|
|
|
regulation of defense response
|
GO:0031347 |
154 |
0.052
|
|
|
|
regulation of cell growth
|
GO:0001558 |
135 |
0.052
|
|
|
|
alcohol metabolic process
|
GO:0006066 |
114 |
0.051
|
|
|
|
innate immune response
|
GO:0045087 |
178 |
0.051
|
Worm |
|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
181 |
0.050
|
|
|
|
cell morphogenesis involved in differentiation
|
GO:0000904 |
144 |
0.050
|
Human Fly |
|
|
negative regulation of cell growth
|
GO:0030308 |
83 |
0.050
|
|
|
|
positive regulation of cell development
|
GO:0010720 |
92 |
0.050
|
|
|
|
protein import
|
GO:0017038 |
130 |
0.049
|
Human |
|
|
positive regulation of biomineral tissue development
|
GO:0070169 |
20 |
0.049
|
Human |
|
|
regulation of cytokine production
|
GO:0001817 |
232 |
0.049
|
|
|
|
nucleotide catabolic process
|
GO:0009166 |
408 |
0.049
|
|
|
|
hindbrain development
|
GO:0030902 |
3 |
0.049
|
|
|
|
myeloid cell differentiation
|
GO:0030099 |
117 |
0.049
|
|
|
|
response to other organism
|
GO:0051707 |
261 |
0.049
|
Worm |
|
|
regulation of ras protein signal transduction
|
GO:0046578 |
155 |
0.048
|
|
|
|
response to organic cyclic compound
|
GO:0014070 |
204 |
0.048
|
Human |
|
|
negative regulation of release of sequestered calcium ion into cytosol
|
GO:0051280 |
1 |
0.048
|
|
|
|
reactive oxygen species metabolic process
|
GO:0072593 |
75 |
0.048
|
Human |
|
|
positive regulation of cytoplasmic transport
|
GO:1903651 |
82 |
0.048
|
Human |
|
|
ubiquitin dependent protein catabolic process
|
GO:0006511 |
206 |
0.047
|
|
|
|
neural crest cell migration
|
GO:0001755 |
2 |
0.047
|
|
|
|
response to alcohol
|
GO:0097305 |
64 |
0.047
|
Human |
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
244 |
0.047
|
|
|
|
protein targeting
|
GO:0006605 |
187 |
0.047
|
Human |
|
|
negative regulation of calcium ion transmembrane transport
|
GO:1903170 |
11 |
0.047
|
|
|
|
retinal ganglion cell axon guidance
|
GO:0031290 |
2 |
0.046
|
|
|
|
proteasomal protein catabolic process
|
GO:0010498 |
176 |
0.046
|
|
|
|
regulation of actin filament based process
|
GO:0032970 |
141 |
0.045
|
|
|
|
regulation of nucleocytoplasmic transport
|
GO:0046822 |
98 |
0.045
|
Human |
|
|
regulation of cell morphogenesis
|
GO:0022604 |
153 |
0.045
|
Worm |
|
|
nitrogen compound transport
|
GO:0071705 |
191 |
0.044
|
|
|
|
neurological system process
|
GO:0050877 |
163 |
0.044
|
|
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
211 |
0.044
|
|
|
|
biomineral tissue development
|
GO:0031214 |
39 |
0.044
|
Human |
|
|
signal transduction by phosphorylation
|
GO:0023014 |
297 |
0.044
|
Human Rat |
|
|
cell development
|
GO:0048468 |
328 |
0.044
|
Human Fly |
|
|
modification dependent protein catabolic process
|
GO:0019941 |
209 |
0.044
|
|
|
|
chemotaxis
|
GO:0006935 |
157 |
0.043
|
Fly |
|
|
regulation of anatomical structure size
|
GO:0090066 |
101 |
0.043
|
|
|
|
epithelial cell fate commitment
|
GO:0072148 |
3 |
0.043
|
Human |
|
|
regulation of biomineral tissue development
|
GO:0070167 |
31 |
0.043
|
Human |
|
|
regulation of protein import into nucleus
|
GO:0042306 |
78 |
0.043
|
Human |
|
|
viral process
|
GO:0016032 |
146 |
0.042
|
|
|
|
negative regulation of cell differentiation
|
GO:0045596 |
171 |
0.042
|
|
|
|
purine nucleotide catabolic process
|
GO:0006195 |
405 |
0.042
|
|
|
|
hematopoietic or lymphoid organ development
|
GO:0048534 |
186 |
0.042
|
|
|
|
urogenital system development
|
GO:0001655 |
65 |
0.042
|
|
|
|
response to alkaloid
|
GO:0043279 |
20 |
0.042
|
|
|
|
tube morphogenesis
|
GO:0035239 |
95 |
0.041
|
Human Zebrafish |
|
|
pathway restricted smad protein phosphorylation
|
GO:0060389 |
38 |
0.041
|
Human Rat Fly |
|
|
actin cytoskeleton organization
|
GO:0030036 |
207 |
0.041
|
|
|
|
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0090100 |
41 |
0.041
|
|
|
|
proteasome mediated ubiquitin dependent protein catabolic process
|
GO:0043161 |
156 |
0.041
|
|
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
411 |
0.040
|
|
|
|
morphogenesis of embryonic epithelium
|
GO:0016331 |
4 |
0.040
|
|
|
|
organic hydroxy compound biosynthetic process
|
GO:1901617 |
71 |
0.040
|
|
|
|
cell part morphogenesis
|
GO:0032990 |
137 |
0.040
|
Fly |
|
|
maintenance of location in cell
|
GO:0051651 |
62 |
0.040
|
Worm |
|
|
protein maturation
|
GO:0051604 |
233 |
0.040
|
|
|
|
lymphatic endothelial cell differentiation
|
GO:0060836 |
3 |
0.040
|
Human |
|
|
neuron development
|
GO:0048666 |
113 |
0.039
|
Fly |
|
|
mitral valve development
|
GO:0003174 |
3 |
0.039
|
Human |
|
|
regulation of protein catabolic process
|
GO:0042176 |
155 |
0.039
|
Worm |
|
|
negative regulation of trophoblast cell migration
|
GO:1901164 |
3 |
0.039
|
Human |
|
|
extracellular structure organization
|
GO:0043062 |
41 |
0.038
|
|
|
|
cellular response to lipid
|
GO:0071396 |
127 |
0.038
|
|
|
|
regulation of anatomical structure morphogenesis
|
GO:0022603 |
286 |
0.037
|
Worm |
|
|
action potential
|
GO:0001508 |
34 |
0.037
|
|
|
|
renal system development
|
GO:0072001 |
63 |
0.037
|
|
|
|
positive regulation of cellular catabolic process
|
GO:0031331 |
284 |
0.037
|
|
|
|
cell junction assembly
|
GO:0034329 |
67 |
0.036
|
Human |
|
|
peptidyl tyrosine phosphorylation
|
GO:0018108 |
170 |
0.036
|
|
|
|
transmission of nerve impulse
|
GO:0019226 |
11 |
0.036
|
|
|
|
potassium ion transmembrane transport
|
GO:0071805 |
60 |
0.036
|
|
|
|
oocyte development
|
GO:0048599 |
1 |
0.036
|
|
|
|
regulation of purine nucleotide catabolic process
|
GO:0033121 |
205 |
0.036
|
|
|
|
female gamete generation
|
GO:0007292 |
2 |
0.036
|
|
|
|
regulation of cell development
|
GO:0060284 |
161 |
0.036
|
|
|
|
nucleoside triphosphate catabolic process
|
GO:0009143 |
394 |
0.036
|
|
|
|
regulation of protein localization to nucleus
|
GO:1900180 |
85 |
0.036
|
Human |
|
|
response to wounding
|
GO:0009611 |
168 |
0.035
|
Human Zebrafish |
|
|
ribonucleoside triphosphate catabolic process
|
GO:0009203 |
391 |
0.035
|
|
|
|
endocytosis
|
GO:0006897 |
159 |
0.035
|
|
|
|
regulation of mitotic cell cycle
|
GO:0007346 |
189 |
0.035
|
Fly |
|
|
regulation of intracellular protein transport
|
GO:0033157 |
123 |
0.035
|
Human |
|
|
small molecule biosynthetic process
|
GO:0044283 |
157 |
0.035
|
|
|
|
mapk cascade
|
GO:0000165 |
288 |
0.035
|
Human |
|
|
defense response to other organism
|
GO:0098542 |
129 |
0.035
|
Worm |
|
|
regulation of myeloid cell differentiation
|
GO:0045637 |
81 |
0.034
|
|
|
|
positive regulation of interleukin 5 production
|
GO:0032754 |
3 |
0.034
|
|
|
|
negative regulation of cation channel activity
|
GO:2001258 |
12 |
0.034
|
|
|
|
receptor metabolic process
|
GO:0043112 |
81 |
0.034
|
|
|
|
single organism nuclear import
|
GO:1902593 |
104 |
0.034
|
Human |
|
|
regulation of nervous system development
|
GO:0051960 |
88 |
0.034
|
|
|
|
single organism cell adhesion
|
GO:0098602 |
179 |
0.033
|
|
|
|
stem cell development
|
GO:0048864 |
69 |
0.033
|
Human |
|
|
steroid metabolic process
|
GO:0008202 |
94 |
0.033
|
|
|
|
potassium ion transport
|
GO:0006813 |
62 |
0.033
|
|
|
|
brain development
|
GO:0007420 |
97 |
0.033
|
Fly |
|
|
fibril organization
|
GO:0097435 |
10 |
0.033
|
|
|
|
fatty acid metabolic process
|
GO:0006631 |
115 |
0.033
|
|
|
|
positive regulation of protein serine threonine kinase activity
|
GO:0071902 |
119 |
0.033
|
Human |
|
|
regulation of ossification
|
GO:0030278 |
58 |
0.033
|
Human |
|
|
secretion by cell
|
GO:0032940 |
226 |
0.033
|
|
|
|
embryo development
|
GO:0009790 |
123 |
0.033
|
Human Zebrafish Mouse |
|
|
defense response to fungus
|
GO:0050832 |
4 |
0.032
|
Worm |
|
|
protein targeting to nucleus
|
GO:0044744 |
104 |
0.032
|
Human |
|
|
purine nucleoside catabolic process
|
GO:0006152 |
398 |
0.032
|
|
|
|
regulation of proteolysis involved in cellular protein catabolic process
|
GO:1903050 |
91 |
0.032
|
|
|
|
response to hormone
|
GO:0009725 |
175 |
0.032
|
|
|
|
response to axon injury
|
GO:0048678 |
1 |
0.032
|
|
|
|
neuron projection regeneration
|
GO:0031102 |
1 |
0.032
|
|
|
|
memory
|
GO:0007613 |
3 |
0.032
|
|
|
|
carbohydrate metabolic process
|
GO:0005975 |
207 |
0.032
|
|
|
|
regulation of cytoskeleton organization
|
GO:0051493 |
177 |
0.032
|
|
|
|
regulation of homeostatic process
|
GO:0032844 |
121 |
0.031
|
|
|
|
kidney development
|
GO:0001822 |
53 |
0.031
|
|
|
|
angiogenesis
|
GO:0001525 |
147 |
0.031
|
Human |
|
|
lymphocyte activation
|
GO:0046649 |
133 |
0.031
|
|
|
|
positive regulation of apoptotic signaling pathway
|
GO:2001235 |
70 |
0.031
|
Human |
|
|
nucleoside catabolic process
|
GO:0009164 |
408 |
0.031
|
|
|
|
epithelial cell proliferation
|
GO:0050673 |
128 |
0.031
|
Human |
|
|
extracellular matrix organization
|
GO:0030198 |
41 |
0.031
|
|
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
190 |
0.030
|
Human |
|
|
response to radiation
|
GO:0009314 |
151 |
0.030
|
Fly |
|
|
osteoblast differentiation
|
GO:0001649 |
92 |
0.030
|
Human |
|
|
rho protein signal transduction
|
GO:0007266 |
26 |
0.030
|
|
|
|
purine ribonucleoside catabolic process
|
GO:0046130 |
398 |
0.030
|
|
|
|
endothelial cell differentiation
|
GO:0045446 |
26 |
0.030
|
Human |
|
|
phosphatidylinositol 3 kinase signaling
|
GO:0014065 |
48 |
0.030
|
|
|
|
peripheral nervous system development
|
GO:0007422 |
2 |
0.030
|
|
|
|
positive regulation of protein transport
|
GO:0051222 |
135 |
0.030
|
Human |
|
|
nerve development
|
GO:0021675 |
4 |
0.030
|
|
|
|
negative regulation of protein transport
|
GO:0051224 |
75 |
0.030
|
|
|
|
response to external biotic stimulus
|
GO:0043207 |
261 |
0.030
|
Worm |
|
|
cell junction organization
|
GO:0034330 |
79 |
0.030
|
Human |
|
|
blood vessel endothelial cell migration
|
GO:0043534 |
42 |
0.030
|
Human |
|
|
circadian behavior
|
GO:0048512 |
2 |
0.030
|
|
|
|
regulation of hormone levels
|
GO:0010817 |
125 |
0.030
|
|
|
|
sodium ion transmembrane transport
|
GO:0035725 |
59 |
0.029
|
|
|
|
positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulus
|
GO:1901522 |
2 |
0.029
|
|
|
|
g1 s transition of mitotic cell cycle
|
GO:0000082 |
78 |
0.029
|
|
|
|
regulation of reactive oxygen species metabolic process
|
GO:2000377 |
41 |
0.029
|
Human |
|
|
regulation of purine nucleotide metabolic process
|
GO:1900542 |
264 |
0.029
|
|
|
|
negative regulation of cell cycle
|
GO:0045786 |
193 |
0.029
|
|
|
|
zymogen activation
|
GO:0031638 |
70 |
0.029
|
|
|
|
guanosine containing compound catabolic process
|
GO:1901069 |
239 |
0.029
|
|
|
|
atrioventricular valve development
|
GO:0003171 |
3 |
0.029
|
Human |
|
|
eye development
|
GO:0001654 |
42 |
0.029
|
|
|
|
cytokine production
|
GO:0001816 |
247 |
0.029
|
|
|
|
mitotic cell cycle phase transition
|
GO:0044772 |
162 |
0.029
|
|
|
|
positive regulation of cysteine type endopeptidase activity
|
GO:2001056 |
79 |
0.029
|
Human |
|
|
blood vessel morphogenesis
|
GO:0048514 |
162 |
0.029
|
Human |
|
|
protein processing
|
GO:0016485 |
226 |
0.028
|
|
|
|
purine ribonucleotide catabolic process
|
GO:0009154 |
404 |
0.028
|
|
|
|
positive regulation of epithelial cell proliferation
|
GO:0050679 |
65 |
0.028
|
Human |
|
|
regulation of cellular component size
|
GO:0032535 |
82 |
0.028
|
|
|
|
sodium ion transport
|
GO:0006814 |
61 |
0.028
|
|
|
|
cellular response to transforming growth factor beta stimulus
|
GO:0071560 |
94 |
0.028
|
Human |
|
|
growth
|
GO:0040007 |
202 |
0.028
|
|
|
|
response to sterol
|
GO:0036314 |
14 |
0.028
|
Human |
|
|
activation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0006919 |
49 |
0.028
|
|
|
|
positive regulation of epithelial cell migration
|
GO:0010634 |
55 |
0.028
|
Human |
|
|
peptidyl threonine phosphorylation
|
GO:0018107 |
41 |
0.028
|
|
|
|
protein localization to nucleus
|
GO:0034504 |
136 |
0.027
|
Human Worm |
|
|
associative learning
|
GO:0008306 |
1 |
0.027
|
|
|
|
regulation of cell morphogenesis involved in differentiation
|
GO:0010769 |
83 |
0.027
|
|
|
|
cellular response to organonitrogen compound
|
GO:0071417 |
124 |
0.027
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
183 |
0.027
|
|
|
|
purine ribonucleoside triphosphate catabolic process
|
GO:0009207 |
391 |
0.027
|
|
|
|
positive regulation of sequence specific dna binding transcription factor activity
|
GO:0051091 |
131 |
0.027
|
|
|
|
heart trabecula morphogenesis
|
GO:0061384 |
1 |
0.027
|
|
|
|
blastoderm segmentation
|
GO:0007350 |
2 |
0.027
|
|
|
|
regulation of secretion
|
GO:0051046 |
194 |
0.027
|
|
|
|
ossification
|
GO:0001503 |
121 |
0.027
|
Human |
|
|
compound eye development
|
GO:0048749 |
1 |
0.027
|
|
|
|
regulation of transforming growth factor beta receptor signaling pathway
|
GO:0017015 |
48 |
0.027
|
|
|
|
cell cell signaling
|
GO:0007267 |
155 |
0.027
|
|
|
|
posttranscriptional regulation of gene expression
|
GO:0010608 |
213 |
0.027
|
|
|
|
positive regulation of endopeptidase activity
|
GO:0010950 |
84 |
0.027
|
Human |
|
|
wound healing
|
GO:0042060 |
115 |
0.027
|
Human Zebrafish |
|
|
gtp catabolic process
|
GO:0006184 |
237 |
0.027
|
|
|
|
synaptic transmission
|
GO:0007268 |
61 |
0.027
|
|
|
|
activation of protein kinase activity
|
GO:0032147 |
90 |
0.026
|
Human |
|
|
regulation of cell activation
|
GO:0050865 |
125 |
0.026
|
|
|
|
single organism cellular localization
|
GO:1902580 |
332 |
0.026
|
Human |
|
|
regulation of gtpase activity
|
GO:0043087 |
180 |
0.026
|
|
|
|
purine containing compound catabolic process
|
GO:0072523 |
411 |
0.026
|
|
|
|
multicellular organismal signaling
|
GO:0035637 |
34 |
0.026
|
|
|
|
positive regulation of osteoblast differentiation
|
GO:0045669 |
23 |
0.026
|
Human |
|
|
erythrocyte differentiation
|
GO:0030218 |
28 |
0.026
|
|
|
|
cell cycle g1 s phase transition
|
GO:0044843 |
80 |
0.026
|
|
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.026
|
Human |
|
|
peptidyl tyrosine modification
|
GO:0018212 |
170 |
0.026
|
|
|
|
transforming growth factor beta receptor signaling pathway
|
GO:0007179 |
76 |
0.025
|
Human |
|
|
regulation of immune effector process
|
GO:0002697 |
91 |
0.025
|
|
|
|
negative regulation of transcription initiation from rna polymerase ii promoter
|
GO:0060633 |
3 |
0.025
|
|
|
|
cell fate determination
|
GO:0001709 |
3 |
0.025
|
Zebrafish |
|
|
regulation of protein targeting
|
GO:1903533 |
91 |
0.025
|
Human |
|
|
neural tube formation
|
GO:0001841 |
3 |
0.025
|
|
|
|
cellular response to external stimulus
|
GO:0071496 |
111 |
0.025
|
Human |
|
|
extrinsic apoptotic signaling pathway
|
GO:0097191 |
119 |
0.025
|
|
