Homo sapiens

100 known processes

AIFM1

apoptosis-inducing factor, mitochondrion-associated, 1

(Aliases: MGC111425,COXPD6,AIF,PDCD8)

AIFM1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
determination of adult lifespan GO:0008340 2 0.843
dicarboxylic acid metabolic process GO:0043648 29 0.810
post embryonic development GO:0009791 2 0.762
Worm
multicellular organismal aging GO:0010259 3 0.538
oxidation reduction process GO:0055114 396 0.512
mitochondrion organization GO:0007005 156 0.462
cofactor biosynthetic process GO:0051188 31 0.458
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 49 0.419
carboxylic acid catabolic process GO:0046395 71 0.391
aerobic respiration GO:0009060 7 0.377
embryo development GO:0009790 123 0.299
Worm
generation of precursor metabolites and energy GO:0006091 68 0.289
vesicle mediated transport GO:0016192 371 0.280
Worm
monocarboxylic acid metabolic process GO:0032787 185 0.274
citrate metabolic process GO:0006101 2 0.266
positive regulation of apoptotic process GO:0043065 246 0.266
glutamine family amino acid metabolic process GO:0009064 17 0.257
glutamate metabolic process GO:0006536 10 0.247
glutamine family amino acid biosynthetic process GO:0009084 5 0.189
tricarboxylic acid metabolic process GO:0072350 4 0.188
nucleoside triphosphate metabolic process GO:0009141 422 0.188
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.179
organic acid catabolic process GO:0016054 71 0.176
purine nucleoside triphosphate metabolic process GO:0009144 412 0.173
nucleoside monophosphate metabolic process GO:0009123 191 0.168
2 oxoglutarate metabolic process GO:0006103 4 0.166
dicarboxylic acid catabolic process GO:0043649 9 0.162
female gamete generation GO:0007292 2 0.162
energy derivation by oxidation of organic compounds GO:0015980 43 0.161
cofactor metabolic process GO:0051186 87 0.159
mitochondrial membrane organization GO:0007006 40 0.158
mitochondrial transport GO:0006839 60 0.151
atp metabolic process GO:0046034 176 0.151
glycerol metabolic process GO:0006071 4 0.150
coenzyme metabolic process GO:0006732 65 0.150
lipid metabolic process GO:0006629 381 0.150
cellular amino acid metabolic process GO:0006520 116 0.146
carbohydrate metabolic process GO:0005975 207 0.145
positive regulation of peptidase activity GO:0010952 88 0.144
acetyl coa biosynthetic process from pyruvate GO:0006086 4 0.143
tricarboxylic acid cycle GO:0006099 4 0.142
positive regulation of hydrolase activity GO:0051345 331 0.138
regulation of membrane potential GO:0042391 95 0.134
cellular amino acid biosynthetic process GO:0008652 30 0.130
small molecule biosynthetic process GO:0044283 157 0.128
fatty acid metabolic process GO:0006631 115 0.122
cellular respiration GO:0045333 21 0.121
purine ribonucleoside metabolic process GO:0046128 437 0.119
dicarboxylic acid biosynthetic process GO:0043650 4 0.109
sulfur compound biosynthetic process GO:0044272 38 0.107
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.101
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.093
oogenesis GO:0048477 2 0.092
endocytosis GO:0006897 159 0.091
Worm
purine nucleoside monophosphate metabolic process GO:0009126 186 0.091
cell development GO:0048468 328 0.087
sulfur compound metabolic process GO:0006790 101 0.086
small molecule catabolic process GO:0044282 92 0.081
aspartate metabolic process GO:0006531 4 0.081
ribonucleoside triphosphate metabolic process GO:0009199 412 0.079
activation of cysteine type endopeptidase activity GO:0097202 57 0.076
cellular amino acid catabolic process GO:0009063 31 0.073
protein processing GO:0016485 226 0.071
oxidative phosphorylation GO:0006119 10 0.071
mitochondrial atp synthesis coupled electron transport GO:0042775 4 0.068
regulation of endopeptidase activity GO:0052548 170 0.067
membrane organization GO:0061024 292 0.066
mitochondrial electron transport nadh to ubiquinone GO:0006120 2 0.062
neuromuscular junction development GO:0007528 3 0.062
cellular lipid metabolic process GO:0044255 303 0.061
alpha amino acid catabolic process GO:1901606 26 0.061
alpha amino acid metabolic process GO:1901605 72 0.061
system process GO:0003008 349 0.060
aspartate family amino acid catabolic process GO:0009068 5 0.058
ribonucleoside monophosphate metabolic process GO:0009161 187 0.057
embryo development ending in birth or egg hatching GO:0009792 34 0.057
Worm
acyl coa biosynthetic process GO:0071616 6 0.052
receptor mediated endocytosis GO:0006898 84 0.052
Worm
protein maturation GO:0051604 233 0.052
single organism cellular localization GO:1902580 332 0.052
coenzyme biosynthetic process GO:0009108 24 0.050
atp synthesis coupled electron transport GO:0042773 4 0.050
growth GO:0040007 202 0.049
regulation of proteolysis GO:0030162 293 0.047
regulation of cysteine type endopeptidase activity GO:2000116 127 0.047
protein localization to mitochondrion GO:0070585 25 0.047
alditol metabolic process GO:0019400 5 0.047
reproduction GO:0000003 63 0.045
Worm
single organism carbohydrate metabolic process GO:0044723 193 0.045
regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902108 18 0.043
response to drug GO:0042493 81 0.043
carbohydrate derivative biosynthetic process GO:1901137 207 0.043
response to organonitrogen compound GO:0010243 156 0.042
regulation of nucleoside metabolic process GO:0009118 209 0.042
immune response GO:0006955 307 0.041
aging GO:0007568 66 0.041
positive regulation of cell death GO:0010942 263 0.039
zymogen activation GO:0031638 70 0.038
acyl coa metabolic process GO:0006637 23 0.037
single organism reproductive process GO:0044702 98 0.036
cellular carbohydrate metabolic process GO:0044262 84 0.035
reactive oxygen species metabolic process GO:0072593 75 0.035
response to hormone GO:0009725 175 0.035
positive regulation of endopeptidase activity GO:0010950 84 0.034
immune system development GO:0002520 195 0.033
positive regulation of programmed cell death GO:0043068 249 0.031
positive regulation of nucleoside metabolic process GO:0045979 186 0.031
cellular amide metabolic process GO:0043603 69 0.031
somatic diversification of immunoglobulins involved in immune response GO:0002208 3 0.031
response to oxidative stress GO:0006979 121 0.031
apoptotic mitochondrial changes GO:0008637 57 0.029
cellular ketone metabolic process GO:0042180 80 0.029
central nervous system development GO:0007417 123 0.029
thioester metabolic process GO:0035383 23 0.029
alcohol biosynthetic process GO:0046165 52 0.028
negative regulation of programmed cell death GO:0043069 321 0.028
alpha amino acid biosynthetic process GO:1901607 23 0.027
cellular amine metabolic process GO:0044106 41 0.027
ion homeostasis GO:0050801 230 0.026
spermatid differentiation GO:0048515 4 0.026
negative regulation of intracellular signal transduction GO:1902532 183 0.025
organonitrogen compound biosynthetic process GO:1901566 200 0.025
positive regulation of proteolysis GO:0045862 142 0.024
cytoplasmic transport GO:0016482 379 0.024
cellular response to oxygen containing compound GO:1901701 276 0.024
cellular protein complex assembly GO:0043623 188 0.024
ion transmembrane transport GO:0034220 338 0.024
intracellular protein transport GO:0006886 270 0.024
multi organism reproductive process GO:0044703 54 0.024
thioester biosynthetic process GO:0035384 6 0.023
response to abiotic stimulus GO:0009628 336 0.023
negative regulation of transport GO:0051051 176 0.023
organic acid biosynthetic process GO:0016053 97 0.023
establishment of protein localization to membrane GO:0090150 121 0.022
rna interference GO:0016246 4 0.022
regulation of purine nucleotide metabolic process GO:1900542 264 0.022
lipid localization GO:0010876 106 0.021
response to oxygen containing compound GO:1901700 369 0.021
carboxylic acid transport GO:0046942 63 0.021
locomotory behavior GO:0007626 1 0.021
hematopoietic or lymphoid organ development GO:0048534 186 0.021
nucleoside monophosphate catabolic process GO:0009125 159 0.021
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.020
reproductive system development GO:0061458 56 0.020
adult locomotory behavior GO:0008344 1 0.020
carboxylic acid biosynthetic process GO:0046394 97 0.020
regulation of peptidase activity GO:0052547 180 0.020
hemopoiesis GO:0030097 180 0.019
reproductive process GO:0022414 106 0.019
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.019
positive regulation of cellular catabolic process GO:0031331 284 0.019
neurological system process GO:0050877 163 0.019
cellular ion homeostasis GO:0006873 168 0.019
regulation of mitochondrial membrane permeability GO:0046902 25 0.018
regulation of mitochondrial membrane potential GO:0051881 23 0.018
regeneration GO:0031099 4 0.018
nucleoside triphosphate catabolic process GO:0009143 394 0.018
apoptotic signaling pathway GO:0097190 268 0.018
respiratory chain complex iv assembly GO:0008535 9 0.018
cellular macromolecular complex assembly GO:0034622 324 0.018
posttranscriptional regulation of gene expression GO:0010608 213 0.018
regulation of apoptotic signaling pathway GO:2001233 175 0.018
alcohol metabolic process GO:0006066 114 0.018
organelle fusion GO:0048284 36 0.018
spermatid development GO:0007286 4 0.018
pyruvate metabolic process GO:0006090 26 0.017
negative regulation of growth GO:0045926 97 0.017
establishment of protein localization to organelle GO:0072594 172 0.017
regulation of growth GO:0040008 165 0.017
cellular cation homeostasis GO:0030003 163 0.017
sleep GO:0030431 2 0.017
response to other organism GO:0051707 261 0.017
positive regulation of immune system process GO:0002684 283 0.016
defense response GO:0006952 315 0.016
multi organism cellular process GO:0044764 156 0.016
organophosphate catabolic process GO:0046434 430 0.016
protein glycosylation GO:0006486 62 0.016
cell cell signaling GO:0007267 155 0.016
negative regulation of phosphorus metabolic process GO:0010563 267 0.016
action potential GO:0001508 34 0.016
nucleotide catabolic process GO:0009166 408 0.016
purine nucleoside catabolic process GO:0006152 398 0.016
response to wounding GO:0009611 168 0.016
transmembrane transport GO:0055085 399 0.016
response to lipid GO:0033993 206 0.015
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.015
positive regulation of catabolic process GO:0009896 310 0.015
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.015
anion transport GO:0006820 161 0.015
wound healing GO:0042060 115 0.015
protein targeting GO:0006605 187 0.015
positive regulation of cellular component organization GO:0051130 376 0.015
cell growth GO:0016049 160 0.015
anatomical structure homeostasis GO:0060249 100 0.015
protein homooligomerization GO:0051260 100 0.014
purine ribonucleoside catabolic process GO:0046130 398 0.014
glutamate biosynthetic process GO:0006537 3 0.014
purine nucleoside triphosphate catabolic process GO:0009146 392 0.014
protein acylation GO:0043543 138 0.014
chemical homeostasis GO:0048878 306 0.014
developmental process involved in reproduction GO:0003006 66 0.014
organic hydroxy compound metabolic process GO:1901615 147 0.014
cellular chemical homeostasis GO:0055082 180 0.014
developmental programmed cell death GO:0010623 3 0.014
maintenance of location GO:0051235 112 0.014
behavior GO:0007610 112 0.014
organic acid transport GO:0015849 65 0.014
response to cytokine GO:0034097 232 0.013
regulation of nucleotide catabolic process GO:0030811 205 0.013
negative regulation of cellular protein metabolic process GO:0032269 353 0.013
lipid catabolic process GO:0016042 84 0.013
response to peptide GO:1901652 65 0.013
regulation of immune response GO:0050776 201 0.013
response to hypoxia GO:0001666 96 0.013
response to external biotic stimulus GO:0043207 261 0.013
negative regulation of phosphate metabolic process GO:0045936 267 0.012
multicellular organismal reproductive process GO:0048609 40 0.012
ribonucleotide catabolic process GO:0009261 405 0.012
ribonucleoside catabolic process GO:0042454 406 0.012
innate immune response GO:0045087 178 0.012
mitochondrial fusion GO:0008053 13 0.012
positive regulation of gtp catabolic process GO:0033126 166 0.012
protein targeting to mitochondrion GO:0006626 19 0.012
regulation of purine nucleotide catabolic process GO:0033121 205 0.012
protein localization to organelle GO:0033365 280 0.012
single organism membrane organization GO:0044802 268 0.012
negative regulation of cell proliferation GO:0008285 228 0.012
response to organic cyclic compound GO:0014070 204 0.012
multicellular organism reproduction GO:0032504 42 0.012
negative regulation of peptidase activity GO:0010466 91 0.012
protein localization to membrane GO:0072657 160 0.012
rna catabolic process GO:0006401 71 0.012
organic anion transport GO:0015711 103 0.011
protein catabolic process GO:0030163 325 0.011
response to biotic stimulus GO:0009607 276 0.011
regulation of behavior GO:0050795 82 0.011
negative regulation of protein modification process GO:0031400 200 0.011
negative regulation of cell death GO:0060548 345 0.011
ribonucleoside triphosphate catabolic process GO:0009203 391 0.011
positive regulation of immune response GO:0050778 159 0.011
negative regulation of cell growth GO:0030308 83 0.011
positive regulation of nucleotide metabolic process GO:0045981 230 0.011
ribose phosphate biosynthetic process GO:0046390 82 0.011
immune effector process GO:0002252 159 0.011
tissue regeneration GO:0042246 3 0.011
organic hydroxy compound biosynthetic process GO:1901617 71 0.011
negative regulation of phosphorylation GO:0042326 174 0.011
dephosphorylation GO:0016311 209 0.011
amine metabolic process GO:0009308 44 0.011
regulation of cell growth GO:0001558 135 0.011
gtp metabolic process GO:0046039 239 0.011
regulation of cytokine production GO:0001817 232 0.011
midbrain development GO:0030901 45 0.011
regulation of response to external stimulus GO:0032101 222 0.011
regulation of hormone levels GO:0010817 125 0.011
cellular response to hypoxia GO:0071456 51 0.011
response to oxygen levels GO:0070482 100 0.010
regulation of membrane permeability GO:0090559 25 0.010
regulation of defense response GO:0031347 154 0.010
sex differentiation GO:0007548 45 0.010
oxaloacetate metabolic process GO:0006107 1 0.010
positive regulation of nucleotide catabolic process GO:0030813 185 0.010
positive regulation of developmental process GO:0051094 314 0.010
cellular macromolecule catabolic process GO:0044265 380 0.010
Worm
nervous system development GO:0007399 293 0.010

AIFM1 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.977
inherited metabolic disorder DOID:655 242 0.977
amino acid metabolic disorder DOID:9252 50 0.749
cancer DOID:162 167 0.129
disease of cellular proliferation DOID:14566 174 0.129
mitochondrial metabolism disease DOID:700 29 0.123
coenzyme q10 deficiency disease DOID:0050730 6 0.123
immune system disease DOID:2914 155 0.065
sensory system disease DOID:0050155 203 0.056
nervous system disease DOID:863 431 0.056
organ system cancer DOID:0050686 164 0.046
central nervous system disease DOID:331 186 0.044
carbohydrate metabolic disorder DOID:2978 55 0.041
eye and adnexa disease DOID:1492 150 0.022
neurodegenerative disease DOID:1289 102 0.018
eye disease DOID:5614 149 0.016
gastrointestinal system cancer DOID:3119 52 0.016
leigh disease DOID:3652 16 0.015
neuromuscular disease DOID:440 38 0.004
neuropathy DOID:870 52 0.004
charcot marie tooth disease DOID:10595 33 0.002
charcot marie tooth disease type x DOID:0050542 3 0.000