Homo sapiens

71 known processes

APP

amyloid beta (A4) precursor protein

(Aliases: CTFgamma,CVAP,AAA,ABETA,AD1,PN2,ABPP,APPI)

APP biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of cellular amine metabolic process GO:0033238 11 1.000
locomotory behavior GO:0007626 1 0.994
Mouse
enzyme linked receptor protein signaling pathway GO:0007167 303 0.985
Mouse
synaptic transmission GO:0007268 61 0.984
Mouse
negative regulation of cell death GO:0060548 345 0.981
Fly
positive regulation of programmed cell death GO:0043068 249 0.973
positive regulation of cell death GO:0010942 263 0.970
system process GO:0003008 349 0.969
Mouse Fly
regulation of cellular amino acid metabolic process GO:0006521 6 0.968
behavior GO:0007610 112 0.964
Mouse Fly
amine metabolic process GO:0009308 44 0.962
positive regulation of protein kinase activity GO:0045860 190 0.961
neurological system process GO:0050877 163 0.960
Mouse Fly
cellular amino acid metabolic process GO:0006520 116 0.957
synaptic vesicle transport GO:0048489 5 0.956
positive regulation of phosphorylation GO:0042327 394 0.954
positive regulation of cellular amine metabolic process GO:0033240 7 0.953
negative regulation of transport GO:0051051 176 0.951
cell type specific apoptotic process GO:0097285 125 0.951
negative regulation of protein metabolic process GO:0051248 391 0.950
membrane organization GO:0061024 292 0.947
regulation of transferase activity GO:0051338 355 0.944
Mouse
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.940
Mouse
negative regulation of multicellular organismal process GO:0051241 317 0.934
Mouse
growth GO:0040007 202 0.933
Mouse Worm
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.932
regulation of cellular ketone metabolic process GO:0010565 50 0.931
transmembrane transport GO:0055085 399 0.929
membrane protein proteolysis GO:0033619 38 0.929
cellular ketone metabolic process GO:0042180 80 0.925
positive regulation of cell cycle GO:0045787 140 0.925
Mouse
taxis GO:0042330 157 0.922
Mouse
protein localization to membrane GO:0072657 160 0.922
regulation of protein serine threonine kinase activity GO:0071900 179 0.921
peptidyl tyrosine phosphorylation GO:0018108 170 0.917
Mouse
regulation of synaptic plasticity GO:0048167 3 0.914
ionotropic glutamate receptor signaling pathway GO:0035235 16 0.913
Mouse
cell development GO:0048468 328 0.913
Zebrafish Mouse Fly
neuron neuron synaptic transmission GO:0007270 6 0.912
response to oxygen containing compound GO:1901700 369 0.897
metal ion transport GO:0030001 272 0.896
positive regulation of apoptotic process GO:0043065 246 0.893
regulation of apoptotic signaling pathway GO:2001233 175 0.893
action potential GO:0001508 34 0.890
neuron projection development GO:0031175 106 0.888
Zebrafish Mouse Fly
neuron differentiation GO:0030182 138 0.872
Zebrafish Mouse Fly
secretion GO:0046903 254 0.870
response to metal ion GO:0010038 84 0.861
negative regulation of protein serine threonine kinase activity GO:0071901 57 0.859
organic anion transport GO:0015711 103 0.859
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.852
positive regulation of cellular component organization GO:0051130 376 0.842
neuron development GO:0048666 113 0.840
Zebrafish Mouse Fly
regulation of map kinase activity GO:0043405 108 0.827
single organism membrane organization GO:0044802 268 0.827
positive regulation of map kinase activity GO:0043406 80 0.825
regulation of ion transport GO:0043269 189 0.824
regulation of protein localization GO:0032880 296 0.808
chemotaxis GO:0006935 157 0.804
Mouse
negative regulation of catalytic activity GO:0043086 335 0.804
negative regulation of cellular protein metabolic process GO:0032269 353 0.803
cellular amine metabolic process GO:0044106 41 0.803
extracellular matrix organization GO:0030198 41 0.801
Mouse
cell projection organization GO:0030030 252 0.798
Zebrafish Mouse Fly
signal transduction by phosphorylation GO:0023014 297 0.798
positive regulation of cell motility GO:2000147 177 0.796
positive regulation of cell migration GO:0030335 172 0.791
regulation of secretion GO:0051046 194 0.779
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.776
negative regulation of developmental process GO:0051093 247 0.772
Mouse
cellular response to oxygen containing compound GO:1901701 276 0.770
visual behavior GO:0007632 2 0.768
Mouse
visual learning GO:0008542 1 0.760
Mouse
positive regulation of apoptotic signaling pathway GO:2001235 70 0.759
membrane protein ectodomain proteolysis GO:0006509 33 0.759
endomembrane system organization GO:0010256 196 0.756
intracellular protein transport GO:0006886 270 0.753
regulation of cell motility GO:2000145 299 0.751
regulation of cell cycle GO:0051726 393 0.750
Mouse
amino acid transport GO:0006865 28 0.749
negative regulation of peptidase activity GO:0010466 91 0.744
single organism cellular localization GO:1902580 332 0.734
neutral lipid metabolic process GO:0006638 27 0.725
regulation of neurotransmitter secretion GO:0046928 3 0.724
regulation of binding GO:0051098 111 0.715
Mouse
negative regulation of programmed cell death GO:0043069 321 0.714
response to inorganic substance GO:0010035 127 0.714
negative regulation of apoptotic process GO:0043066 316 0.712
neurotransmitter secretion GO:0007269 4 0.698
response to radiation GO:0009314 151 0.698
Mouse
response to external biotic stimulus GO:0043207 261 0.696
negative regulation of cell development GO:0010721 48 0.696
Mouse
cell cell signaling GO:0007267 155 0.693
Mouse
positive regulation of synaptic transmission GO:0050806 4 0.690
regulation of protein transport GO:0051223 213 0.689
serotonin uptake GO:0051610 2 0.687
regulation of establishment of protein localization GO:0070201 242 0.682
neurogenesis GO:0022008 169 0.673
Zebrafish Mouse Fly
establishment of vesicle localization GO:0051650 23 0.669
positive regulation of mesenchymal cell proliferation GO:0002053 2 0.665
synaptic vesicle endocytosis GO:0048488 2 0.665
ras protein signal transduction GO:0007265 73 0.661
epithelium development GO:0060429 227 0.660
Zebrafish
regulation of locomotion GO:0040012 329 0.657
positive regulation of dna metabolic process GO:0051054 73 0.652
negative regulation of cell differentiation GO:0045596 171 0.646
Mouse
positive regulation of intracellular transport GO:0032388 104 0.642
plasma membrane organization GO:0007009 115 0.641
chemical homeostasis GO:0048878 306 0.635
Mouse
cation homeostasis GO:0055080 189 0.627
Mouse
positive regulation of fibroblast migration GO:0010763 3 0.626
apoptotic signaling pathway GO:0097190 268 0.624
regulation of mapk cascade GO:0043408 262 0.621
nervous system development GO:0007399 293 0.620
Zebrafish Mouse Fly
protein import GO:0017038 130 0.620
peptidyl threonine phosphorylation GO:0018107 41 0.619
compound eye development GO:0048749 1 0.615
positive regulation of kinase activity GO:0033674 204 0.612
associative learning GO:0008306 1 0.610
Mouse
leukocyte activation GO:0045321 164 0.604
positive regulation of transferase activity GO:0051347 227 0.602
negative regulation of cell cycle GO:0045786 193 0.599
lipid metabolic process GO:0006629 381 0.598
Mouse
nuclear import GO:0051170 106 0.593
neuron apoptotic process GO:0051402 39 0.591
striated muscle tissue development GO:0014706 59 0.589
regulation of lipid metabolic process GO:0019216 96 0.586
positive regulation of developmental process GO:0051094 314 0.583
Worm
regulation of neuron differentiation GO:0045664 70 0.576
Mouse
internal protein amino acid acetylation GO:0006475 101 0.570
regulation of cell migration GO:0030334 289 0.569
regulation of membrane potential GO:0042391 95 0.568
vesicle mediated transport GO:0016192 371 0.566
Mouse
regulation of protein secretion GO:0050708 86 0.564
response to drug GO:0042493 81 0.563
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.561
regulation of kinase activity GO:0043549 314 0.556
Mouse
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.548
cellular component morphogenesis GO:0032989 314 0.538
Zebrafish Mouse Fly
regulation of cell growth GO:0001558 135 0.537
amyloid precursor protein metabolic process GO:0042982 17 0.536
response to transition metal nanoparticle GO:1990267 29 0.530
nucleoside catabolic process GO:0009164 408 0.525
cellular response to metal ion GO:0071248 43 0.524
negative regulation of interleukin 13 secretion GO:2000666 1 0.520
positive regulation of mapk cascade GO:0043410 190 0.520
positive regulation of transport GO:0051050 336 0.519
ion transmembrane transport GO:0034220 338 0.514
protein targeting to nucleus GO:0044744 104 0.514
regulation of cellular component movement GO:0051270 334 0.511
cell morphogenesis GO:0000902 296 0.509
Zebrafish Mouse Fly
synaptic vesicle localization GO:0097479 5 0.508
regulation of carbohydrate metabolic process GO:0006109 54 0.502
regulation of protein kinase activity GO:0045859 289 0.502
Mouse
receptor localization to synapse GO:0097120 1 0.502
interleukin 13 secretion GO:0072611 2 0.500
cerebral cortex cell migration GO:0021795 3 0.492
negative regulation of synaptic transmission GO:0050805 2 0.489
negative regulation of secretion GO:0051048 58 0.487
response to other organism GO:0051707 261 0.486
cell cycle arrest GO:0007050 71 0.484
extrinsic apoptotic signaling pathway GO:0097191 119 0.483
cellular response to dna damage stimulus GO:0006974 379 0.482
divalent metal ion transport GO:0070838 152 0.480
positive regulation of cellular component movement GO:0051272 181 0.476
regulation of proteolysis GO:0030162 293 0.476
cardiovascular system development GO:0072358 262 0.475
Zebrafish
regulation of intracellular transport GO:0032386 195 0.453
response to hormone GO:0009725 175 0.451
protein localization to plasma membrane GO:0072659 93 0.449
extracellular structure organization GO:0043062 41 0.449
Mouse
protein secretion GO:0009306 98 0.447
organic acid transport GO:0015849 65 0.445
neuron projection morphogenesis GO:0048812 50 0.442
Zebrafish Mouse Fly
synaptic vesicle exocytosis GO:0016079 3 0.440
neuron death GO:0070997 65 0.431
positive regulation of protein phosphorylation GO:0001934 313 0.431
carbohydrate biosynthetic process GO:0016051 42 0.428
negative regulation of platelet derived growth factor receptor signaling pathway GO:0010642 4 0.427
protein import into nucleus GO:0006606 104 0.423
positive regulation of intracellular protein transport GO:0090316 76 0.418
establishment of protein localization to organelle GO:0072594 172 0.414
nuclear transport GO:0051169 179 0.413
regulation of neurogenesis GO:0050767 82 0.409
Mouse
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 26 0.405
sterol transport GO:0015918 39 0.404
negative regulation of hydrolase activity GO:0051346 182 0.404
erbb signaling pathway GO:0038127 44 0.399
Mouse
positive regulation of catabolic process GO:0009896 310 0.395
embryo development GO:0009790 123 0.392
peptidyl serine modification GO:0018209 106 0.388
internal peptidyl lysine acetylation GO:0018393 97 0.386
mapk cascade GO:0000165 288 0.384
establishment of synaptic vesicle localization GO:0097480 5 0.382
response to growth factor GO:0070848 205 0.379
positive regulation of secretion GO:0051047 116 0.379
dna repair GO:0006281 198 0.379
regulation of excitatory postsynaptic membrane potential GO:0060079 1 0.377
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.375
regulation of protein catabolic process GO:0042176 155 0.375
negative regulation of interleukin 5 production GO:0032714 3 0.373
positive regulation of secretion by cell GO:1903532 108 0.371
myeloid cell differentiation GO:0030099 117 0.368
regulation of fat cell differentiation GO:0045598 23 0.365
negative regulation of protein modification process GO:0031400 200 0.362
cellular amide metabolic process GO:0043603 69 0.361
cellular response to external stimulus GO:0071496 111 0.354
regulation of dna repair GO:0006282 47 0.354
multicellular organismal aging GO:0010259 3 0.352
neuroblast proliferation GO:0007405 4 0.352
cell morphogenesis involved in differentiation GO:0000904 144 0.351
Zebrafish Mouse
mitochondrion organization GO:0007005 156 0.350
regulation of endopeptidase activity GO:0052548 170 0.349
brain morphogenesis GO:0048854 1 0.349
cellular divalent inorganic cation homeostasis GO:0072503 128 0.345
Mouse
response to oxidative stress GO:0006979 121 0.344
Mouse
hair follicle maturation GO:0048820 3 0.344
sleep GO:0030431 2 0.342
protein processing GO:0016485 226 0.341
protein acetylation GO:0006473 116 0.339
regulation of protein binding GO:0043393 66 0.337
Mouse
vesicle localization GO:0051648 26 0.335
determination of adult lifespan GO:0008340 2 0.331
mitotic cell cycle phase transition GO:0044772 162 0.331
Mouse
regulation of neuron death GO:1901214 56 0.330
Fly
cellular chemical homeostasis GO:0055082 180 0.329
Mouse
positive regulation of cytoplasmic transport GO:1903651 82 0.328
regulation of atrial cardiac muscle cell membrane repolarization GO:0060372 4 0.327
cell activation GO:0001775 213 0.326
cytokine production GO:0001816 247 0.325
negative regulation of phosphorylation GO:0042326 174 0.324
cellular response to growth factor stimulus GO:0071363 197 0.321
neuronal action potential GO:0019228 9 0.321
peptide metabolic process GO:0006518 51 0.320
carbohydrate derivative biosynthetic process GO:1901137 207 0.317
chromatin organization GO:0006325 351 0.316
secretion by cell GO:0032940 226 0.316
regulation of carbohydrate biosynthetic process GO:0043255 27 0.316
limb development GO:0060173 23 0.315
positive regulation of protein import into nucleus GO:0042307 46 0.308
response to wounding GO:0009611 168 0.306
Fly
negative regulation of apoptotic signaling pathway GO:2001234 97 0.306
response to biotic stimulus GO:0009607 276 0.303
cation transport GO:0006812 331 0.300
regulation of intracellular protein transport GO:0033157 123 0.300
regulation of nucleoside metabolic process GO:0009118 209 0.299
myeloid leukocyte activation GO:0002274 34 0.296
negative regulation of cell proliferation GO:0008285 228 0.295
cellular response to organic cyclic compound GO:0071407 127 0.294
positive regulation of protein transport GO:0051222 135 0.294
positive regulation of cell growth GO:0030307 48 0.291
post embryonic development GO:0009791 2 0.289
Worm
regulation of cellular response to stress GO:0080135 244 0.287
regulation of canonical wnt signaling pathway GO:0060828 88 0.285
negative regulation of cell adhesion GO:0007162 64 0.284
forebrain development GO:0030900 26 0.284
Mouse
generation of neurons GO:0048699 152 0.281
Zebrafish Mouse Fly
peripheral nervous system development GO:0007422 2 0.279
Fly
negative regulation of endopeptidase activity GO:0010951 84 0.275
regulation of cell cycle process GO:0010564 266 0.274
Mouse
cytoplasmic transport GO:0016482 379 0.273
cardiac muscle cell proliferation GO:0060038 6 0.270
axon development GO:0061564 34 0.269
Zebrafish Mouse
cell projection morphogenesis GO:0048858 129 0.269
Zebrafish Mouse Fly
single organism cell adhesion GO:0098602 179 0.266
protein localization to synapse GO:0035418 2 0.266
circulatory system process GO:0003013 113 0.265
protein acylation GO:0043543 138 0.261
negative regulation of proteolysis GO:0045861 132 0.260
cell growth GO:0016049 160 0.259
Mouse
response to reactive oxygen species GO:0000302 61 0.259
salivary gland morphogenesis GO:0007435 4 0.256
dicarboxylic acid transport GO:0006835 13 0.253
t cell receptor signaling pathway GO:0050852 21 0.252
regulation of peptidase activity GO:0052547 180 0.249
osteoclast differentiation GO:0030316 21 0.249
cell part morphogenesis GO:0032990 137 0.247
Zebrafish Mouse Fly
central nervous system development GO:0007417 123 0.246
Zebrafish Mouse
negative regulation of cytokine production GO:0001818 82 0.245
peptidyl lysine acetylation GO:0018394 101 0.243
alcohol metabolic process GO:0006066 114 0.237
Mouse
cellular lipid metabolic process GO:0044255 303 0.237
regulation of interleukin 13 secretion GO:2000665 2 0.237
organ morphogenesis GO:0009887 147 0.237
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.237
skeletal system development GO:0001501 79 0.236
cellular response to lipid GO:0071396 127 0.235
histone acetylation GO:0016573 93 0.235
organic hydroxy compound metabolic process GO:1901615 147 0.234
Mouse
fat cell differentiation GO:0045444 32 0.232
synaptic vesicle recycling GO:0036465 3 0.232
regulation of metal ion transport GO:0010959 120 0.232
carbohydrate metabolic process GO:0005975 207 0.232
regeneration GO:0031099 4 0.232
mesenchymal cell development GO:0014031 50 0.230
regulation of dna metabolic process GO:0051052 153 0.228
muscle structure development GO:0061061 98 0.227
protein catabolic process GO:0030163 325 0.226
negative regulation of cell migration GO:0030336 102 0.226
dna replication GO:0006260 116 0.226
protein localization to organelle GO:0033365 280 0.226
response to abiotic stimulus GO:0009628 336 0.223
Mouse
positive regulation of ras gtpase activity GO:0032320 117 0.222
positive regulation of cell proliferation GO:0008284 301 0.221
cellular macromolecule catabolic process GO:0044265 380 0.220
cholesterol transport GO:0030301 39 0.220
adult locomotory behavior GO:0008344 1 0.218
Mouse
negative regulation of growth GO:0045926 97 0.218
cell division GO:0051301 168 0.216
response to extracellular stimulus GO:0009991 85 0.214
positive regulation of cardioblast differentiation GO:0051891 2 0.212
mitotic cell cycle process GO:1903047 286 0.212
Mouse
negative regulation of protein maturation GO:1903318 142 0.209
single organism behavior GO:0044708 28 0.207
Mouse Fly
positive regulation of organelle organization GO:0010638 195 0.207
negative regulation of interleukin 5 secretion GO:2000663 1 0.206
transmission of nerve impulse GO:0019226 11 0.206
actin cytoskeleton organization GO:0030036 207 0.206
peptidyl lysine modification GO:0018205 144 0.205
regulation of calcium ion transport GO:0051924 79 0.204
endochondral bone morphogenesis GO:0060350 3 0.204
stress activated protein kinase signaling cascade GO:0031098 94 0.204
cerebral cortex radially oriented cell migration GO:0021799 1 0.202
positive regulation of hair follicle maturation GO:0048818 2 0.202
somatic stem cell division GO:0048103 1 0.202
response to lipid GO:0033993 206 0.200
response to steroid hormone GO:0048545 80 0.200
cell morphogenesis involved in neuron differentiation GO:0048667 44 0.200
Zebrafish Mouse
retina vasculature morphogenesis in camera type eye GO:0061299 3 0.199
regulation of small gtpase mediated signal transduction GO:0051056 156 0.198
negative regulation of cell growth GO:0030308 83 0.197
axon guidance GO:0007411 12 0.196
Mouse
collateral sprouting GO:0048668 2 0.196
Mouse
cell chemotaxis GO:0060326 112 0.195
positive regulation of inositol phosphate biosynthetic process GO:0060732 2 0.194
regulation of neuronal synaptic plasticity GO:0048168 1 0.194
positive regulation of protein catabolic process GO:0045732 75 0.194
single organism nuclear import GO:1902593 104 0.193
regulation of protein maturation GO:1903317 150 0.193
organelle fission GO:0048285 149 0.193
regulation of secretion by cell GO:1903530 177 0.191
response to nutrient levels GO:0031667 81 0.191
muscle tissue development GO:0060537 62 0.190
negative regulation of transferase activity GO:0051348 124 0.187
positive regulation of immune system process GO:0002684 283 0.185
lymphocyte activation GO:0046649 133 0.184
regulation of postsynaptic membrane potential GO:0060078 1 0.182
transforming growth factor beta receptor signaling pathway GO:0007179 76 0.182
nucleocytoplasmic transport GO:0006913 176 0.181
protein localization to nucleus GO:0034504 136 0.181
cell adhesion GO:0007155 325 0.180
circadian behavior GO:0048512 2 0.180
immune response GO:0006955 307 0.180
cellular component disassembly GO:0022411 92 0.179
negative regulation of protein processing GO:0010955 142 0.179
regulation of protein targeting GO:1903533 91 0.178
regulation of interleukin 5 secretion GO:2000662 2 0.178
negative regulation of glycoprotein metabolic process GO:1903019 8 0.177
response to temperature stimulus GO:0009266 22 0.176
steroid metabolic process GO:0008202 94 0.176
Mouse
response to bacterium GO:0009617 144 0.175
positive regulation of epithelial cell proliferation GO:0050679 65 0.175
sensory organ development GO:0007423 52 0.175
protein targeting GO:0006605 187 0.174
neurotransmitter gated ion channel clustering GO:0072578 1 0.173
establishment of organelle localization GO:0051656 59 0.173
carboxylic acid transport GO:0046942 63 0.172
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 85 0.171
regulation of epithelial cell proliferation GO:0050678 113 0.168
regulation of interleukin 17 production GO:0032660 12 0.167
membrane hyperpolarization GO:0060081 1 0.166
interleukin 5 secretion GO:0072603 2 0.163
positive regulation of cell cycle process GO:0090068 106 0.163
Mouse
regulation of n methyl d aspartate selective glutamate receptor activity GO:2000310 1 0.161
exocytosis GO:0006887 71 0.160
positive regulation of cellular catabolic process GO:0031331 284 0.160
posttranscriptional regulation of gene expression GO:0010608 213 0.158
Mouse
small gtpase mediated signal transduction GO:0007264 78 0.158
negative regulation of catabolic process GO:0009895 104 0.156
response to organic cyclic compound GO:0014070 204 0.155
mating GO:0007618 1 0.155
Mouse
negative regulation of phosphate metabolic process GO:0045936 267 0.154
cellular macromolecular complex assembly GO:0034622 324 0.151
single organism carbohydrate metabolic process GO:0044723 193 0.150
positive regulation of hydrolase activity GO:0051345 331 0.148
Rat
regulation of neuron projection development GO:0010975 57 0.148
metal ion homeostasis GO:0055065 169 0.146
Mouse
covalent chromatin modification GO:0016569 254 0.146
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.146
cardiac muscle cell contraction GO:0086003 4 0.144
organonitrogen compound biosynthetic process GO:1901566 200 0.144
positive regulation of protein secretion GO:0050714 60 0.143
establishment of protein localization to membrane GO:0090150 121 0.141
embryonic morphogenesis GO:0048598 85 0.141
positive regulation of epithelial cell migration GO:0010634 55 0.140
chromatin modification GO:0016568 298 0.140
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.139
blood vessel morphogenesis GO:0048514 162 0.138
regulation of epithelial cell migration GO:0010632 93 0.138
cellular response to inorganic substance GO:0071241 45 0.138
reactive oxygen species metabolic process GO:0072593 75 0.138
myeloid leukocyte differentiation GO:0002573 60 0.138
polysaccharide metabolic process GO:0005976 33 0.138
blood vessel development GO:0001568 172 0.137
negative regulation of cellular component organization GO:0051129 235 0.136
microglial cell activation GO:0001774 2 0.135
adaptive immune response GO:0002250 49 0.135
negative regulation of phosphorus metabolic process GO:0010563 267 0.135
actin filament based process GO:0030029 224 0.135
endothelial cell migration GO:0043542 86 0.134
brain development GO:0007420 97 0.133
Mouse
regulation of lymphocyte proliferation GO:0050670 64 0.133
regulation of rho protein signal transduction GO:0035023 79 0.133
endocytosis GO:0006897 159 0.133
Mouse
purine ribonucleoside metabolic process GO:0046128 437 0.132
regulation of nucleotide metabolic process GO:0006140 269 0.131
hair follicle morphogenesis GO:0031069 2 0.130
cell cycle phase transition GO:0044770 173 0.129
Mouse
axonogenesis GO:0007409 31 0.129
Zebrafish Mouse
positive regulation of locomotion GO:0040017 186 0.129
cellular response to endogenous stimulus GO:0071495 336 0.129
regulation of actin cytoskeleton organization GO:0032956 116 0.129
single organismal cell cell adhesion GO:0016337 148 0.128
immune system development GO:0002520 195 0.127
eye development GO:0001654 42 0.127
endothelial cell proliferation GO:0001935 65 0.126
regulation of cell adhesion GO:0030155 166 0.126
regulation of blood vessel endothelial cell migration GO:0043535 30 0.124
negative regulation of protein phosphorylation GO:0001933 140 0.124
positive regulation of cytosolic calcium ion concentration GO:0007204 82 0.124
ameboidal type cell migration GO:0001667 135 0.123
regulation of leukocyte activation GO:0002694 115 0.123
regulation of response to dna damage stimulus GO:2001020 94 0.123
regulation of system process GO:0044057 101 0.122
postsynaptic membrane organization GO:0001941 2 0.122
long term synaptic potentiation GO:0060291 1 0.121
regulation of cytoplasmic transport GO:1903649 149 0.121
nucleoside phosphate catabolic process GO:1901292 412 0.121
sensory perception GO:0007600 103 0.119
neuron projection regeneration GO:0031102 1 0.119
head development GO:0060322 108 0.119
Mouse
spinal cord development GO:0021510 4 0.118
positive regulation of wnt signaling pathway GO:0030177 54 0.118
organophosphate catabolic process GO:0046434 430 0.117
peptidyl serine phosphorylation GO:0018105 101 0.117
negative regulation of cellular component movement GO:0051271 106 0.116
negative regulation of cell motility GO:2000146 104 0.116
autophagy GO:0006914 88 0.116
interleukin 17 production GO:0032620 12 0.115
cellular protein complex assembly GO:0043623 188 0.114
t cell activation GO:0042110 99 0.114
response to cytokine GO:0034097 232 0.113
regulation of cytoskeleton organization GO:0051493 177 0.113
cdc42 protein signal transduction GO:0032488 4 0.113
actin filament organization GO:0007015 128 0.112
divalent inorganic cation transport GO:0072511 158 0.112
circulatory system development GO:0072359 262 0.112
Zebrafish
regulation of mitotic cell cycle GO:0007346 189 0.112
Mouse
neural crest cell migration GO:0001755 2 0.111
positive regulation of jak stat cascade GO:0046427 35 0.111
negative regulation of canonical wnt signaling pathway GO:0090090 55 0.111
anion transport GO:0006820 161 0.111
axon regeneration GO:0031103 1 0.110
cellular response to starvation GO:0009267 58 0.110
regulation of rho gtpase activity GO:0032319 66 0.110
neural crest cell development GO:0014032 3 0.109
leukocyte differentiation GO:0002521 98 0.109
reactive oxygen species biosynthetic process GO:1903409 4 0.109
bone development GO:0060348 26 0.108
cerebral cortex development GO:0021987 10 0.108
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 48 0.107
axon cargo transport GO:0008088 2 0.107
Mouse
regulation of protein processing GO:0070613 150 0.106
protein oligomerization GO:0051259 173 0.106
calcium ion transport GO:0006816 147 0.106
regulation of calcium ion transport into cytosol GO:0010522 33 0.106
lymphocyte proliferation GO:0046651 70 0.104
organic hydroxy compound transport GO:0015850 63 0.104
negative regulation of locomotion GO:0040013 118 0.104
muscle organ development GO:0007517 56 0.104
reactive nitrogen species metabolic process GO:2001057 3 0.104

APP disease predictions

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 186 0.997
nervous system disease DOID:863 431 0.997
neurodegenerative disease DOID:1289 102 0.975
disease of mental health DOID:150 70 0.961
cognitive disorder DOID:1561 29 0.831
dementia DOID:1307 19 0.635
alzheimer s disease DOID:10652 16 0.635
tauopathy DOID:680 16 0.635
disease of metabolism DOID:0014667 295 0.341
acquired metabolic disease DOID:0060158 58 0.341
brain disease DOID:936 73 0.187
cancer DOID:162 167 0.112
disease of cellular proliferation DOID:14566 174 0.112