Homo sapiens

6 known processes

ASAH1

N-acylsphingosine amidohydrolase (acid ceramidase) 1

(Aliases: AC,PHP,ACDase,PHP32,FLJ22079,FLJ21558,ASAH)

ASAH1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
granzyme mediated apoptotic signaling pathway GO:0008626 4 0.549
negative regulation of glycoprotein metabolic process GO:1903019 8 0.210
epithelium migration GO:0090132 119 0.172
lipid localization GO:0010876 106 0.136
apoptotic signaling pathway GO:0097190 268 0.119
negative regulation of multicellular organismal process GO:0051241 317 0.111
regulation of secretion GO:0051046 194 0.099
regulation of cell motility GO:2000145 299 0.095
post embryonic development GO:0009791 2 0.095
female gamete generation GO:0007292 2 0.091
signal transduction by phosphorylation GO:0023014 297 0.084
mapk cascade GO:0000165 288 0.079
lipid metabolic process GO:0006629 381 0.077
regulation of locomotion GO:0040012 329 0.073
response to hormone GO:0009725 175 0.072
wnt signaling pathway GO:0016055 156 0.071
golgi to vacuole transport GO:0006896 3 0.070
cellular lipid metabolic process GO:0044255 303 0.070
positive regulation of transport GO:0051050 336 0.068
regulation of protein localization GO:0032880 296 0.067
lysosomal transport GO:0007041 33 0.065
post golgi vesicle mediated transport GO:0006892 36 0.065
regulation of cell migration GO:0030334 289 0.064
chemical homeostasis GO:0048878 306 0.062
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.061
positive regulation of immune system process GO:0002684 283 0.061
cytoplasmic transport GO:0016482 379 0.060
negative regulation of cell motility GO:2000146 104 0.060
lipid biosynthetic process GO:0008610 177 0.059
regulation of cellular component movement GO:0051270 334 0.057
cellular amide metabolic process GO:0043603 69 0.057
positive regulation of cellular catabolic process GO:0031331 284 0.057
positive regulation of natural killer cell activation GO:0032816 8 0.055
regulation of peptidase activity GO:0052547 180 0.054
leukocyte mediated immunity GO:0002443 59 0.053
positive regulation of secretion GO:0051047 116 0.053
enzyme linked receptor protein signaling pathway GO:0007167 303 0.052
regulation of cellular response to growth factor stimulus GO:0090287 76 0.051
positive regulation of natural killer cell mediated cytotoxicity GO:0045954 11 0.050
response to bacterium GO:0009617 144 0.050
response to oxidative stress GO:0006979 121 0.050
organophosphate biosynthetic process GO:0090407 163 0.048
positive regulation of catabolic process GO:0009896 310 0.047
natural killer cell activation involved in immune response GO:0002323 2 0.047
cellular ketone metabolic process GO:0042180 80 0.047
lipid catabolic process GO:0016042 84 0.045
regulation of lymphocyte mediated immunity GO:0002706 33 0.045
positive regulation of leukocyte mediated immunity GO:0002705 24 0.045
secretion by cell GO:0032940 226 0.044
positive regulation of exocytosis GO:0045921 35 0.043
natural killer cell degranulation GO:0043320 2 0.043
regulation of wnt signaling pathway GO:0030111 123 0.043
circulatory system development GO:0072359 262 0.043
regulation of mapk cascade GO:0043408 262 0.042
ameboidal type cell migration GO:0001667 135 0.041
cellular response to endogenous stimulus GO:0071495 336 0.040
blood vessel morphogenesis GO:0048514 162 0.040
protein stabilization GO:0050821 64 0.039
regulation of protein stability GO:0031647 87 0.039
organic anion transport GO:0015711 103 0.039
cholesterol transport GO:0030301 39 0.038
vacuolar transport GO:0007034 34 0.038
sphingolipid metabolic process GO:0006665 38 0.038
cellular amino acid metabolic process GO:0006520 116 0.037
regulation of amyloid precursor protein biosynthetic process GO:0042984 4 0.037
organelle fusion GO:0048284 36 0.037
protein catabolic process GO:0030163 325 0.037
cellular response to growth factor stimulus GO:0071363 197 0.036
vasculature development GO:0001944 181 0.036
intracellular protein transport GO:0006886 270 0.035
oogenesis GO:0048477 2 0.035
immune response GO:0006955 307 0.035
innate immune response GO:0045087 178 0.034
positive regulation of leukocyte degranulation GO:0043302 3 0.034
membrane lipid metabolic process GO:0006643 53 0.033
positive regulation of phosphorylation GO:0042327 394 0.033
posttranscriptional regulation of gene expression GO:0010608 213 0.032
cellular ion homeostasis GO:0006873 168 0.032
purine nucleoside triphosphate metabolic process GO:0009144 412 0.031
positive regulation of cellular amine metabolic process GO:0033240 7 0.031
regulation of leukocyte mediated immunity GO:0002703 38 0.031
negative regulation of protein metabolic process GO:0051248 391 0.030
negative regulation of cellular response to growth factor stimulus GO:0090288 41 0.030
lymphocyte mediated immunity GO:0002449 48 0.030
regulation of cellular amino acid metabolic process GO:0006521 6 0.029
positive regulation of secretion by cell GO:1903532 108 0.029
regulation of cytokine production GO:0001817 232 0.029
response to other organism GO:0051707 261 0.028
response to thyroid hormone GO:0097066 9 0.028
cellular homeostasis GO:0019725 196 0.028
response to biotic stimulus GO:0009607 276 0.028
positive regulation of cellular component organization GO:0051130 376 0.028
endothelial cell migration GO:0043542 86 0.027
single organism membrane organization GO:0044802 268 0.027
response to external biotic stimulus GO:0043207 261 0.027
positive regulation of cell cycle GO:0045787 140 0.027
regulation of immune response GO:0050776 201 0.026
anion transport GO:0006820 161 0.026
regulation of cellular response to stress GO:0080135 244 0.026
mating GO:0007618 1 0.025
positive regulation of gtpase activity GO:0043547 166 0.025
response to growth factor GO:0070848 205 0.025
inorganic cation transmembrane transport GO:0098662 194 0.025
regulation of multi organism process GO:0043900 157 0.024
cellular amine metabolic process GO:0044106 41 0.024
exocytosis GO:0006887 71 0.024
protein localization to organelle GO:0033365 280 0.023
positive regulation of immune response GO:0050778 159 0.023
cellular response to oxidative stress GO:0034599 85 0.023
immune effector process GO:0002252 159 0.023
tissue migration GO:0090130 119 0.023
cell activation GO:0001775 213 0.023
regulation of defense response GO:0031347 154 0.023
positive regulation of cell motility GO:2000147 177 0.023
protein processing GO:0016485 226 0.023
lipid transport GO:0006869 90 0.022
peptide metabolic process GO:0006518 51 0.022
natural killer cell mediated cytotoxicity GO:0042267 23 0.021
negative regulation of cellular component organization GO:0051129 235 0.021
microtubule based movement GO:0007018 32 0.021
regulation of lipid metabolic process GO:0019216 96 0.021
determination of adult lifespan GO:0008340 2 0.021
Worm
regulation of immune effector process GO:0002697 91 0.021
response to virus GO:0009615 126 0.021
negative regulation of blood pressure GO:0045776 3 0.021
regulation of glycoprotein metabolic process GO:1903018 19 0.021
cellular response to hormone stimulus GO:0032870 125 0.021
ion transmembrane transport GO:0034220 338 0.021
negative regulation of apoptotic process GO:0043066 316 0.020
cellular response to oxygen containing compound GO:1901701 276 0.020
regulation of protein maturation GO:1903317 150 0.020
regulation of protein catabolic process GO:0042176 155 0.020
cellular hormone metabolic process GO:0034754 41 0.020
positive regulation of nucleotide catabolic process GO:0030813 185 0.020
positive regulation of organelle organization GO:0010638 195 0.020
glycoprotein metabolic process GO:0009100 110 0.020
regulation of blood vessel endothelial cell migration GO:0043535 30 0.020
regulation of epithelial cell migration GO:0010632 93 0.020
amyloid precursor protein biosynthetic process GO:0042983 4 0.019
secretion GO:0046903 254 0.019
microtubule based process GO:0007017 210 0.019
regulation of intracellular transport GO:0032386 195 0.019
ceramide metabolic process GO:0006672 25 0.019
maintenance of location GO:0051235 112 0.019
regulation of exocytosis GO:0017157 46 0.019
cell growth GO:0016049 160 0.019
regulation of cell cycle GO:0051726 393 0.019
regulation of cell differentiation GO:0045595 393 0.019
angiogenesis GO:0001525 147 0.018
regulation of syncytium formation by plasma membrane fusion GO:0060142 2 0.018
protein maturation GO:0051604 233 0.018
cation homeostasis GO:0055080 189 0.018
regulation of natural killer cell mediated immunity GO:0002715 16 0.018
regulation of purine nucleotide metabolic process GO:1900542 264 0.018
hormone metabolic process GO:0042445 61 0.018
regulation of leukocyte mediated cytotoxicity GO:0001910 19 0.018
regulation of autophagy GO:0010506 52 0.018
positive regulation of protein phosphorylation GO:0001934 313 0.018
regulation of microtubule based process GO:0032886 74 0.018
carbohydrate transport GO:0008643 37 0.018
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.017
leukocyte mediated cytotoxicity GO:0001909 27 0.017
peripheral nervous system development GO:0007422 2 0.017
response to oxygen containing compound GO:1901700 369 0.017
organic hydroxy compound metabolic process GO:1901615 147 0.017
regulation of lipid biosynthetic process GO:0046890 47 0.017
negative regulation of programmed cell death GO:0043069 321 0.017
cellular component disassembly GO:0022411 92 0.017
golgi vesicle transport GO:0048193 80 0.017
negative regulation of protein processing GO:0010955 142 0.017
cation transmembrane transport GO:0098655 238 0.017
compound eye development GO:0048749 1 0.017
positive regulation of hydrolase activity GO:0051345 331 0.017
carbohydrate metabolic process GO:0005975 207 0.017
rho protein signal transduction GO:0007266 26 0.017
regulation of cell killing GO:0031341 22 0.017
cholesterol efflux GO:0033344 28 0.017
regulation of innate immune response GO:0045088 97 0.016
negative regulation of fibroblast growth factor receptor signaling pathway GO:0040037 2 0.016
divalent inorganic cation homeostasis GO:0072507 136 0.016
regulation of secretion by cell GO:1903530 177 0.016
negative regulation of amyloid precursor protein biosynthetic process GO:0042985 2 0.016
amine metabolic process GO:0009308 44 0.016
regulation of organelle transport along microtubule GO:1902513 2 0.016
protein localization to membrane GO:0072657 160 0.016
cytoskeleton dependent intracellular transport GO:0030705 21 0.016
positive regulation of cell proliferation GO:0008284 301 0.016
cd4 positive alpha beta t cell cytokine production GO:0035743 4 0.015
positive regulation of apoptotic process GO:0043065 246 0.015
regulation of membrane potential GO:0042391 95 0.015
syncytium formation by plasma membrane fusion GO:0000768 2 0.015
sterol transport GO:0015918 39 0.015
regulation of establishment of protein localization GO:0070201 242 0.015
regulation of anatomical structure size GO:0090066 101 0.015
locomotory behavior GO:0007626 1 0.015
vesicle mediated transport GO:0016192 371 0.015
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.014
morphogenesis of a polarized epithelium GO:0001738 3 0.014
transforming growth factor beta receptor signaling pathway GO:0007179 76 0.014
regulation of cellular component biogenesis GO:0044087 281 0.014
regulation of cell projection organization GO:0031344 107 0.014
positive regulation of protein catabolic process GO:0045732 75 0.014
biological adhesion GO:0022610 331 0.014
positive regulation of cell migration GO:0030335 172 0.014
actin filament based process GO:0030029 224 0.014
protein localization to synapse GO:0035418 2 0.014
organic hydroxy compound transport GO:0015850 63 0.014
regulation of anatomical structure morphogenesis GO:0022603 286 0.014
negative regulation of cellular protein metabolic process GO:0032269 353 0.014
extrinsic apoptotic signaling pathway GO:0097191 119 0.014
lysosome organization GO:0007040 24 0.014
regulation of cellular ketone metabolic process GO:0010565 50 0.014
positive regulation of cell killing GO:0031343 19 0.014
cellular lipid catabolic process GO:0044242 65 0.014
cardiovascular system development GO:0072358 262 0.014
vacuole organization GO:0007033 44 0.014
positive regulation of regulated secretory pathway GO:1903307 8 0.014
endomembrane system organization GO:0010256 196 0.014
regulation of cellular amine metabolic process GO:0033238 11 0.013
blood vessel development GO:0001568 172 0.013
cell projection organization GO:0030030 252 0.013
purine ribonucleoside metabolic process GO:0046128 437 0.013
regulation of natural killer cell mediated cytotoxicity GO:0042269 16 0.013
negative regulation of cell death GO:0060548 345 0.013
regulation of angiotensin levels in blood GO:0002002 3 0.013
negative regulation of glycoprotein biosynthetic process GO:0010561 5 0.013
cellular protein catabolic process GO:0044257 261 0.013
purine ribonucleotide catabolic process GO:0009154 404 0.013
positive regulation of mapk cascade GO:0043410 190 0.013
response to steroid hormone GO:0048545 80 0.013
defense response GO:0006952 315 0.013
lytic vacuole organization GO:0080171 24 0.013
epithelial cell migration GO:0010631 119 0.013
negative regulation of peptidase activity GO:0010466 91 0.013
regulation of nucleotide metabolic process GO:0006140 269 0.012
transmembrane transport GO:0055085 399 0.012
cellular metal ion homeostasis GO:0006875 146 0.012
ribonucleotide catabolic process GO:0009261 405 0.012
adaptive immune response GO:0002250 49 0.012
natural killer cell mediated immunity GO:0002228 23 0.012
cellular cation homeostasis GO:0030003 163 0.012
nervous system development GO:0007399 293 0.012
cell chemotaxis GO:0060326 112 0.012
growth GO:0040007 202 0.012
neuron projection development GO:0031175 106 0.012
diterpenoid metabolic process GO:0016101 20 0.012
single organism carbohydrate metabolic process GO:0044723 193 0.012
regeneration GO:0031099 4 0.012
natural killer cell activation GO:0030101 12 0.012
negative regulation of transport GO:0051051 176 0.012
glial cell migration GO:0008347 4 0.012
response to axon injury GO:0048678 1 0.012
carboxylic acid transport GO:0046942 63 0.012
regulation of lymphocyte activation GO:0051249 103 0.012
cell killing GO:0001906 34 0.012
epithelial cell proliferation GO:0050673 128 0.012
negative regulation of catalytic activity GO:0043086 335 0.012
nucleoside triphosphate catabolic process GO:0009143 394 0.011
purine nucleoside triphosphate catabolic process GO:0009146 392 0.011
myeloid cell differentiation GO:0030099 117 0.011
eye pigmentation GO:0048069 1 0.011
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.011
negative regulation of locomotion GO:0040013 118 0.011
single organism cellular localization GO:1902580 332 0.011
liposaccharide metabolic process GO:1903509 27 0.011
taxis GO:0042330 157 0.011
response to inorganic substance GO:0010035 127 0.011
regulation of systemic arterial blood pressure by hormone GO:0001990 12 0.011
multicellular organismal signaling GO:0035637 34 0.011
regulation of organelle assembly GO:1902115 40 0.011
leukocyte activation involved in immune response GO:0002366 30 0.011
regulation of gtpase activity GO:0043087 180 0.011
positive regulation of nucleoside metabolic process GO:0045979 186 0.011
membrane organization GO:0061024 292 0.011
regulation of endopeptidase activity GO:0052548 170 0.011
regulation of protein localization to plasma membrane GO:1903076 40 0.011
inorganic ion transmembrane transport GO:0098660 231 0.011
establishment of protein localization to membrane GO:0090150 121 0.011
organic acid transport GO:0015849 65 0.011
substrate adhesion dependent cell spreading GO:0034446 41 0.011
leukocyte migration GO:0050900 107 0.010
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 0.010
regulation of protein processing GO:0070613 150 0.010
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.010
cellular response to external stimulus GO:0071496 111 0.010
sulfur compound metabolic process GO:0006790 101 0.010
cytokine production GO:0001816 247 0.010
cell adhesion GO:0007155 325 0.010
regulation of response to external stimulus GO:0032101 222 0.010
positive regulation of protein transport GO:0051222 135 0.010
organophosphate catabolic process GO:0046434 430 0.010
cellular macromolecule catabolic process GO:0044265 380 0.010
regulation of endothelial cell proliferation GO:0001936 56 0.010
regulation of proteolysis GO:0030162 293 0.010
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.010
positive regulation of ras gtpase activity GO:0032320 117 0.010
regulation of protein secretion GO:0050708 86 0.010

ASAH1 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.997
inherited metabolic disorder DOID:655 242 0.997
lysosomal storage disease DOID:3211 47 0.996
cerebral degeneration DOID:1443 16 0.329
central nervous system disease DOID:331 186 0.329
brain disease DOID:936 73 0.329
nervous system disease DOID:863 431 0.329
immune system disease DOID:2914 155 0.160
sensory system disease DOID:0050155 203 0.036
eye and adnexa disease DOID:1492 150 0.036
lipid storage disease DOID:9455 28 0.035
acquired metabolic disease DOID:0060158 58 0.031
retinal disease DOID:5679 118 0.018
eye disease DOID:5614 149 0.018
epilepsy syndrome DOID:1826 41 0.017
variable age at onset electroclinical syndrome DOID:0050706 8 0.017
electroclinical syndrome DOID:0050701 32 0.017
progressive myoclonus epilepsy DOID:891 8 0.016
cancer DOID:162 167 0.016
disease of cellular proliferation DOID:14566 174 0.016
sphingolipidosis DOID:1927 14 0.016
hematopoietic system disease DOID:74 100 0.015
retinal degeneration DOID:8466 89 0.010