|
|
positive regulation of i kappab kinase nf kappab signaling
|
GO:0043123 |
132 |
1.000
|
Human |
|
|
peptidyl serine autophosphorylation
|
GO:0036289 |
2 |
1.000
|
|
|
|
regulation of i kappab kinase nf kappab signaling
|
GO:0043122 |
162 |
1.000
|
Human |
|
|
cellular response to muramyl dipeptide
|
GO:0071225 |
3 |
1.000
|
|
|
|
i kappab kinase nf kappab signaling
|
GO:0007249 |
166 |
1.000
|
Human |
|
|
activation of innate immune response
|
GO:0002218 |
55 |
1.000
|
|
|
|
programmed necrotic cell death
|
GO:0097300 |
18 |
1.000
|
|
|
|
response to muramyl dipeptide
|
GO:0032495 |
4 |
1.000
|
|
|
|
positive regulation of tumor necrosis factor superfamily cytokine production
|
GO:1903557 |
22 |
1.000
|
|
|
|
toll like receptor 2 signaling pathway
|
GO:0034134 |
4 |
1.000
|
|
|
|
positive regulation of interleukin 8 production
|
GO:0032757 |
36 |
1.000
|
|
|
|
positive regulation of defense response
|
GO:0031349 |
87 |
1.000
|
|
|
|
immune response activating signal transduction
|
GO:0002757 |
90 |
1.000
|
|
|
|
positive regulation of sequence specific dna binding transcription factor activity
|
GO:0051091 |
131 |
1.000
|
|
|
|
regulation of extrinsic apoptotic signaling pathway
|
GO:2001236 |
85 |
1.000
|
|
|
|
tumor necrosis factor production
|
GO:0032640 |
43 |
1.000
|
|
|
|
positive regulation of cytokine production
|
GO:0001819 |
167 |
1.000
|
|
|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
1.000
|
|
|
|
regulation of tumor necrosis factor production
|
GO:0032680 |
43 |
0.999
|
|
|
|
positive regulation of immune response
|
GO:0050778 |
159 |
0.999
|
|
|
|
negative regulation of extrinsic apoptotic signaling pathway
|
GO:2001237 |
52 |
0.999
|
|
|
|
pattern recognition receptor signaling pathway
|
GO:0002221 |
48 |
0.999
|
|
|
|
positive regulation of extrinsic apoptotic signaling pathway
|
GO:2001238 |
26 |
0.999
|
|
|
|
activation of immune response
|
GO:0002253 |
114 |
0.999
|
|
|
|
positive regulation of apoptotic signaling pathway
|
GO:2001235 |
70 |
0.998
|
|
|
|
positive regulation of stress activated mapk cascade
|
GO:0032874 |
60 |
0.998
|
|
|
|
regulation of cytokine production
|
GO:0001817 |
232 |
0.998
|
|
|
|
apoptotic signaling pathway
|
GO:0097190 |
268 |
0.998
|
|
|
|
protein modification by small protein conjugation
|
GO:0032446 |
342 |
0.998
|
|
|
|
necroptotic process
|
GO:0070266 |
16 |
0.998
|
|
|
|
extrinsic apoptotic signaling pathway
|
GO:0097191 |
119 |
0.998
|
|
|
|
positive regulation of myeloid leukocyte differentiation
|
GO:0002763 |
24 |
0.998
|
|
|
|
negative regulation of apoptotic signaling pathway
|
GO:2001234 |
97 |
0.998
|
|
|
|
positive regulation of nf kappab transcription factor activity
|
GO:0051092 |
81 |
0.998
|
|
|
|
adaptive immune response
|
GO:0002250 |
49 |
0.998
|
|
|
|
positive regulation of immune system process
|
GO:0002684 |
283 |
0.997
|
|
|
|
regulation of cellular response to stress
|
GO:0080135 |
244 |
0.997
|
|
|
|
regulation of anion transport
|
GO:0044070 |
25 |
0.997
|
|
|
|
positive regulation of myeloid cell differentiation
|
GO:0045639 |
39 |
0.997
|
|
|
|
interleukin 2 production
|
GO:0032623 |
20 |
0.997
|
|
|
|
positive regulation of stress activated protein kinase signaling cascade
|
GO:0070304 |
61 |
0.997
|
|
|
|
regulation of reactive oxygen species metabolic process
|
GO:2000377 |
41 |
0.997
|
Mouse |
|
|
cytokine production
|
GO:0001816 |
247 |
0.996
|
|
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
175 |
0.996
|
|
|
|
protein ubiquitination
|
GO:0016567 |
314 |
0.995
|
|
|
|
response to tumor necrosis factor
|
GO:0034612 |
76 |
0.995
|
|
|
|
innate immune response activating signal transduction
|
GO:0002758 |
48 |
0.995
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.993
|
|
|
|
positive regulation of jnk cascade
|
GO:0046330 |
52 |
0.993
|
|
|
|
immune system development
|
GO:0002520 |
195 |
0.993
|
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
249 |
0.992
|
|
|
|
toll like receptor signaling pathway
|
GO:0002224 |
25 |
0.992
|
|
|
|
cellular response to biotic stimulus
|
GO:0071216 |
71 |
0.991
|
|
|
|
carbohydrate derivative transport
|
GO:1901264 |
20 |
0.991
|
|
|
|
positive regulation of interleukin 2 production
|
GO:0032743 |
11 |
0.990
|
|
|
|
regulation of macrophage differentiation
|
GO:0045649 |
9 |
0.990
|
|
|
|
regulation of ion transmembrane transport
|
GO:0034765 |
132 |
0.989
|
|
|
|
regulation of leukocyte differentiation
|
GO:1902105 |
61 |
0.988
|
|
|
|
response to oxygen containing compound
|
GO:1901700 |
369 |
0.988
|
|
|
|
cellular response to cytokine stimulus
|
GO:0071345 |
181 |
0.988
|
|
|
|
regulation of nucleoside transport
|
GO:0032242 |
1 |
0.987
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.987
|
|
|
|
positive regulation of production of molecular mediator of immune response
|
GO:0002702 |
11 |
0.987
|
|
|
|
protein polyubiquitination
|
GO:0000209 |
110 |
0.986
|
Human |
|
|
ripoptosome assembly
|
GO:0097343 |
1 |
0.986
|
|
|
|
cell type specific apoptotic process
|
GO:0097285 |
125 |
0.984
|
Human |
|
|
response to cytokine
|
GO:0034097 |
232 |
0.983
|
|
|
|
regulation of t cell proliferation
|
GO:0042129 |
42 |
0.982
|
|
|
|
response to molecule of bacterial origin
|
GO:0002237 |
82 |
0.981
|
|
|
|
hemopoiesis
|
GO:0030097 |
180 |
0.981
|
|
|
|
regulation of necroptotic process
|
GO:0060544 |
7 |
0.979
|
|
|
|
cytoplasmic pattern recognition receptor signaling pathway
|
GO:0002753 |
12 |
0.977
|
|
|
|
positive regulation of innate immune response
|
GO:0045089 |
79 |
0.976
|
|
|
|
cytokine mediated signaling pathway
|
GO:0019221 |
109 |
0.975
|
|
|
|
regulation of leukocyte proliferation
|
GO:0070663 |
67 |
0.973
|
|
|
|
anion transport
|
GO:0006820 |
161 |
0.973
|
|
|
|
positive regulation of apoptotic process
|
GO:0043065 |
246 |
0.971
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.971
|
|
|
|
immune response
|
GO:0006955 |
307 |
0.970
|
|
|
|
regulation of protein modification by small protein conjugation or removal
|
GO:1903320 |
107 |
0.970
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
11 |
0.970
|
|
|
|
response to nitrogen compound
|
GO:1901698 |
184 |
0.969
|
|
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
211 |
0.967
|
|
|
|
mononuclear cell proliferation
|
GO:0032943 |
71 |
0.966
|
|
|
|
defense response
|
GO:0006952 |
315 |
0.965
|
|
|
|
innate immune response
|
GO:0045087 |
178 |
0.965
|
|
|
|
response to biotic stimulus
|
GO:0009607 |
276 |
0.964
|
|
|
|
regulation of transmembrane transporter activity
|
GO:0022898 |
74 |
0.964
|
|
|
|
regulation of cytokine production involved in immune response
|
GO:0002718 |
22 |
0.963
|
|
|
|
cellular response to molecule of bacterial origin
|
GO:0071219 |
62 |
0.961
|
|
|
|
positive regulation of protein modification by small protein conjugation or removal
|
GO:1903322 |
61 |
0.956
|
|
|
|
regulation of innate immune response
|
GO:0045088 |
97 |
0.955
|
|
|
|
stress activated mapk cascade
|
GO:0051403 |
93 |
0.954
|
|
|
|
leukocyte differentiation
|
GO:0002521 |
98 |
0.953
|
|
|
|
positive regulation of mapk cascade
|
GO:0043410 |
190 |
0.950
|
|
|
|
interleukin 8 production
|
GO:0032637 |
51 |
0.950
|
|
|
|
nucleoside transport
|
GO:0015858 |
8 |
0.950
|
|
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
380 |
0.950
|
Human |
|
|
peptidyl serine phosphorylation
|
GO:0018105 |
101 |
0.949
|
|
|
|
regulation of protein ubiquitination
|
GO:0031396 |
95 |
0.949
|
|
|
|
regulation of adaptive immune response
|
GO:0002819 |
33 |
0.947
|
|
|
|
positive regulation of tumor necrosis factor production
|
GO:0032760 |
21 |
0.946
|
|
|
|
regulation of jnk cascade
|
GO:0046328 |
73 |
0.945
|
|
|
|
regulation of leukocyte activation
|
GO:0002694 |
115 |
0.943
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
80 |
0.942
|
|
|
|
protein k63 linked ubiquitination
|
GO:0070534 |
31 |
0.941
|
Human |
|
|
mapk cascade
|
GO:0000165 |
288 |
0.939
|
|
|
|
regulation of tumor necrosis factor superfamily cytokine production
|
GO:1903555 |
44 |
0.938
|
|
|
|
immune response regulating signaling pathway
|
GO:0002764 |
97 |
0.938
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
41 |
0.937
|
|
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.937
|
Human Mouse |
|
|
positive regulation of cell death
|
GO:0010942 |
263 |
0.937
|
|
|
|
regulation of immune response
|
GO:0050776 |
201 |
0.935
|
|
|
|
regulation of mononuclear cell proliferation
|
GO:0032944 |
65 |
0.934
|
|
|
|
regulation of lymphocyte apoptotic process
|
GO:0070228 |
15 |
0.933
|
Human |
|
|
protein homooligomerization
|
GO:0051260 |
100 |
0.932
|
|
|
|
positive regulation of necroptotic process
|
GO:0060545 |
2 |
0.930
|
|
|
|
cellular response to tumor necrosis factor
|
GO:0071356 |
63 |
0.930
|
|
|
|
positive regulation of macrophage differentiation
|
GO:0045651 |
7 |
0.928
|
|
|
|
nucleotide binding domain leucine rich repeat containing receptor signaling pathway
|
GO:0035872 |
5 |
0.924
|
|
|
|
positive regulation of leukocyte differentiation
|
GO:1902107 |
37 |
0.920
|
|
|
|
response to peptidoglycan
|
GO:0032494 |
3 |
0.920
|
|
|
|
leukocyte apoptotic process
|
GO:0071887 |
31 |
0.919
|
Human |
|
|
stress activated protein kinase signaling cascade
|
GO:0031098 |
94 |
0.914
|
|
|
|
regulation of ion transmembrane transporter activity
|
GO:0032412 |
72 |
0.913
|
|
|
|
regulation of necrotic cell death
|
GO:0010939 |
9 |
0.912
|
|
|
|
regulation of myeloid cell differentiation
|
GO:0045637 |
81 |
0.908
|
|
|
|
lipopolysaccharide mediated signaling pathway
|
GO:0031663 |
26 |
0.904
|
|
|
|
regulation of lymphocyte activation
|
GO:0051249 |
103 |
0.903
|
|
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.903
|
Human |
|
|
positive regulation of necrotic cell death
|
GO:0010940 |
4 |
0.902
|
|
|
|
cellular response to oxygen containing compound
|
GO:1901701 |
276 |
0.902
|
|
|
|
regulation of myeloid leukocyte differentiation
|
GO:0002761 |
39 |
0.894
|
|
|
|
ion transmembrane transport
|
GO:0034220 |
338 |
0.888
|
|
|
|
t cell proliferation
|
GO:0042098 |
45 |
0.882
|
|
|
|
response to interleukin 1
|
GO:0070555 |
47 |
0.880
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
204 |
0.875
|
|
|
|
regulation of cell differentiation
|
GO:0045595 |
393 |
0.872
|
|
|
|
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
|
GO:2001240 |
16 |
0.872
|
|
|
|
cytokine biosynthetic process
|
GO:0042089 |
37 |
0.868
|
|
|
|
regulation of cd8 positive alpha beta t cell proliferation
|
GO:2000564 |
1 |
0.868
|
|
|
|
regulation of mapk cascade
|
GO:0043408 |
262 |
0.860
|
|
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
313 |
0.858
|
|
|
|
lymphocyte apoptotic process
|
GO:0070227 |
20 |
0.854
|
Human |
|
|
detection of muramyl dipeptide
|
GO:0032498 |
1 |
0.851
|
|
|
|
nucleotide binding oligomerization domain containing 2 signaling pathway
|
GO:0070431 |
4 |
0.848
|
|
|
|
protein oligomerization
|
GO:0051259 |
173 |
0.847
|
Rat |
|
|
regulation of leukocyte apoptotic process
|
GO:2000106 |
25 |
0.846
|
Human |
|
|
leukocyte mediated immunity
|
GO:0002443 |
59 |
0.844
|
|
|
|
cellular response to lipopolysaccharide
|
GO:0071222 |
57 |
0.844
|
|
|
|
cell activation
|
GO:0001775 |
213 |
0.840
|
|
|
|
positive regulation of cell activation
|
GO:0050867 |
81 |
0.838
|
|
|
|
macrophage differentiation
|
GO:0030225 |
11 |
0.835
|
|
|
|
regulation of defense response
|
GO:0031347 |
154 |
0.833
|
|
|
|
positive regulation of jun kinase activity
|
GO:0043507 |
23 |
0.830
|
|
|
|
regulation of t helper cell differentiation
|
GO:0045622 |
3 |
0.828
|
|
|
|
positive regulation of cell differentiation
|
GO:0045597 |
211 |
0.828
|
|
|
|
erk1 and erk2 cascade
|
GO:0070371 |
104 |
0.828
|
|
|
|
negative regulation of programmed cell death
|
GO:0043069 |
321 |
0.825
|
Human Mouse |
|
|
signal transduction by phosphorylation
|
GO:0023014 |
297 |
0.823
|
|
|
|
tumor necrosis factor superfamily cytokine production
|
GO:0071706 |
45 |
0.822
|
|
|
|
regulation of lymphocyte proliferation
|
GO:0050670 |
64 |
0.821
|
|
|
|
positive regulation of peptidyl serine phosphorylation
|
GO:0033138 |
42 |
0.820
|
|
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.816
|
|
|
|
immune response activating cell surface receptor signaling pathway
|
GO:0002429 |
45 |
0.815
|
|
|
|
myeloid leukocyte differentiation
|
GO:0002573 |
60 |
0.813
|
|
|
|
regulation of peptidyl tyrosine phosphorylation
|
GO:0050730 |
108 |
0.812
|
|
|
|
jnk cascade
|
GO:0007254 |
80 |
0.799
|
|
|
|
amyloid fibril formation
|
GO:1990000 |
3 |
0.799
|
|
|
|
positive regulation of t cell cytokine production
|
GO:0002726 |
4 |
0.796
|
|
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.796
|
|
|
|
hematopoietic or lymphoid organ development
|
GO:0048534 |
186 |
0.790
|
|
|
|
lymphocyte activation
|
GO:0046649 |
133 |
0.789
|
|
|
|
cellular response to lipid
|
GO:0071396 |
127 |
0.789
|
|
|
|
activation of protein kinase activity
|
GO:0032147 |
90 |
0.786
|
|
|
|
alpha beta t cell proliferation
|
GO:0046633 |
5 |
0.783
|
|
|
|
regulation of transporter activity
|
GO:0032409 |
82 |
0.782
|
|
|
|
fibril organization
|
GO:0097435 |
10 |
0.778
|
|
|
|
cd4 positive alpha beta t cell differentiation
|
GO:0043367 |
4 |
0.774
|
|
|
|
positive regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043280 |
69 |
0.770
|
|
|
|
regulation of immune effector process
|
GO:0002697 |
91 |
0.768
|
|
|
|
response to bacterium
|
GO:0009617 |
144 |
0.765
|
|
|
|
leukocyte proliferation
|
GO:0070661 |
74 |
0.758
|
|
|
|
immune effector process
|
GO:0002252 |
159 |
0.757
|
|
|
|
protein trimerization
|
GO:0070206 |
20 |
0.742
|
|
|
|
regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043281 |
116 |
0.740
|
Human |
|
|
regulation of stress activated mapk cascade
|
GO:0032872 |
84 |
0.736
|
|
|
|
defense response to other organism
|
GO:0098542 |
129 |
0.728
|
|
|
|
interleukin 6 production
|
GO:0032635 |
37 |
0.728
|
|
|
|
negative regulation of i kappab kinase nf kappab signaling
|
GO:0043124 |
32 |
0.722
|
|
|
|
cd4 positive alpha beta t cell differentiation involved in immune response
|
GO:0002294 |
4 |
0.719
|
|
|
|
reactive oxygen species metabolic process
|
GO:0072593 |
75 |
0.700
|
Mouse |
|
|
positive regulation of peptidyl tyrosine phosphorylation
|
GO:0050731 |
85 |
0.698
|
|
|
|
positive regulation of t helper cell differentiation
|
GO:0045624 |
2 |
0.691
|
|
|
|
myeloid cell differentiation
|
GO:0030099 |
117 |
0.690
|
|
|
|
regulation of cell activation
|
GO:0050865 |
125 |
0.690
|
|
|
|
alpha beta t cell differentiation
|
GO:0046632 |
7 |
0.689
|
|
|
|
osteoclast differentiation
|
GO:0030316 |
21 |
0.676
|
|
|
|
regulation of interleukin 8 production
|
GO:0032677 |
49 |
0.671
|
|
|
|
t helper 1 cell differentiation
|
GO:0045063 |
1 |
0.663
|
|
|
|
positive regulation of adaptive immune response
|
GO:0002821 |
21 |
0.663
|
|
|
|
positive regulation of protein linear polyubiquitination
|
GO:1902530 |
2 |
0.663
|
Human |
|
|
response to lipoteichoic acid
|
GO:0070391 |
3 |
0.662
|
|
|
|
positive regulation of canonical wnt signaling pathway
|
GO:0090263 |
33 |
0.660
|
Human |
|
|
positive regulation of cytokine biosynthetic process
|
GO:0042108 |
25 |
0.659
|
|
|
|
cytokine metabolic process
|
GO:0042107 |
38 |
0.656
|
|
|
|
intrinsic apoptotic signaling pathway in response to dna damage
|
GO:0008630 |
50 |
0.655
|
|
|
|
nucleotide binding oligomerization domain containing signaling pathway
|
GO:0070423 |
4 |
0.650
|
|
|
|
regulation of ion transport
|
GO:0043269 |
189 |
0.647
|
|
|
|
positive regulation of protein ubiquitination
|
GO:0031398 |
53 |
0.641
|
|
|
|
regulation of peptidase activity
|
GO:0052547 |
180 |
0.638
|
Human |
|
|
extrinsic apoptotic signaling pathway via death domain receptors
|
GO:0008625 |
42 |
0.637
|
|
|
|
response to lipid
|
GO:0033993 |
206 |
0.637
|
|
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
190 |
0.637
|
|
|
|
positive regulation of osteoclast differentiation
|
GO:0045672 |
9 |
0.633
|
|
|
|
nucleobase containing compound transport
|
GO:0015931 |
51 |
0.622
|
|
|
|
response to dsrna
|
GO:0043331 |
25 |
0.621
|
|
|
|
regulation of erk1 and erk2 cascade
|
GO:0070372 |
99 |
0.611
|
|
|
|
trail activated apoptotic signaling pathway
|
GO:0036462 |
4 |
0.608
|
|
|
|
antigen receptor mediated signaling pathway
|
GO:0050851 |
38 |
0.608
|
|
|
|
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002824 |
19 |
0.607
|
|
|
|
cellular response to external stimulus
|
GO:0071496 |
111 |
0.607
|
|
|
|
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002822 |
29 |
0.602
|
|
|
|
nitrogen compound transport
|
GO:0071705 |
191 |
0.600
|
|
|
|
regulation of interleukin 2 production
|
GO:0032663 |
19 |
0.598
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
7 |
0.593
|
|
|
|
activation of nf kappab inducing kinase activity
|
GO:0007250 |
9 |
0.585
|
|
|
|
necrotic cell death
|
GO:0070265 |
21 |
0.585
|
|
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
127 |
0.581
|
|
|
|
cellular response to nitrogen compound
|
GO:1901699 |
144 |
0.580
|
|
|
|
protein catabolic process
|
GO:0030163 |
325 |
0.576
|
Human |
|
|
protein k48 linked ubiquitination
|
GO:0070936 |
38 |
0.567
|
Human |
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
6 |
0.560
|
|
|
|
natural killer cell apoptotic process
|
GO:0070246 |
1 |
0.559
|
Human |
|
|
cellular response to organonitrogen compound
|
GO:0071417 |
124 |
0.548
|
|
|
|
t cell activation
|
GO:0042110 |
99 |
0.547
|
|
|
|
positive regulation of protein polyubiquitination
|
GO:1902916 |
3 |
0.546
|
Human |
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.545
|
|
|
|
regulation of interleukin 1 production
|
GO:0032652 |
21 |
0.543
|
|
|
|
response to lipopolysaccharide
|
GO:0032496 |
70 |
0.542
|
|
|
|
cellular response to endogenous stimulus
|
GO:0071495 |
336 |
0.538
|
|
|
|
nik nf kappab signaling
|
GO:0038061 |
12 |
0.532
|
|
|
|
cellular protein catabolic process
|
GO:0044257 |
261 |
0.526
|
Human |
|
|
protein autoubiquitination
|
GO:0051865 |
37 |
0.526
|
|
|
|
negative regulation of multicellular organismal process
|
GO:0051241 |
317 |
0.523
|
|
|
|
positive regulation of mhc class i biosynthetic process
|
GO:0045345 |
4 |
0.516
|
|
|
|
positive regulation of endopeptidase activity
|
GO:0010950 |
84 |
0.515
|
|
|
|
response to virus
|
GO:0009615 |
126 |
0.510
|
|
|
|
canonical wnt signaling pathway
|
GO:0060070 |
116 |
0.509
|
Human |
|
|
lymphocyte proliferation
|
GO:0046651 |
70 |
0.496
|
|
|
|
regulation of atp adp antiporter activity
|
GO:0070926 |
1 |
0.487
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
289 |
0.477
|
|
|
|
intracellular receptor signaling pathway
|
GO:0030522 |
104 |
0.473
|
|
|
|
positive regulation of cd4 positive alpha beta t cell differentiation
|
GO:0043372 |
2 |
0.472
|
|
|
|
t cell differentiation
|
GO:0030217 |
29 |
0.472
|
|
|
|
regulation of cytokine biosynthetic process
|
GO:0042035 |
35 |
0.471
|
|
|
|
response to external biotic stimulus
|
GO:0043207 |
261 |
0.470
|
|
|
|
cd8 positive alpha beta t cell proliferation
|
GO:0035740 |
1 |
0.468
|
|
|
|
cellular extravasation
|
GO:0045123 |
21 |
0.468
|
|
|
|
positive regulation of protein k48 linked ubiquitination
|
GO:1902524 |
1 |
0.466
|
Human |
|
|
regulation of protein monoubiquitination
|
GO:1902525 |
1 |
0.449
|
Human |
|
|
positive regulation of protein homodimerization activity
|
GO:0090073 |
5 |
0.447
|
|
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.446
|
|
|
|
positive regulation of cell proliferation
|
GO:0008284 |
301 |
0.442
|
|
|
|
regulation of protein linear polyubiquitination
|
GO:1902528 |
2 |
0.439
|
Human |
|
|
cytokine production involved in immune response
|
GO:0002367 |
27 |
0.438
|
|
|
|
immature t cell proliferation
|
GO:0033079 |
1 |
0.434
|
|
|
|
regulation of leukocyte migration
|
GO:0002685 |
63 |
0.429
|
|
|
|
peptidyl serine modification
|
GO:0018209 |
106 |
0.427
|
|
|
|
peptidyl threonine phosphorylation
|
GO:0018107 |
41 |
0.424
|
|
|
|
peptidyl tyrosine phosphorylation
|
GO:0018108 |
170 |
0.423
|
|
|
|
regulation of interferon gamma production
|
GO:0032649 |
36 |
0.418
|
|
|
|
regulation of peptidyl serine phosphorylation
|
GO:0033135 |
50 |
0.418
|
|
|
|
leukocyte activation
|
GO:0045321 |
164 |
0.416
|
|
|
|
regulation of intrinsic apoptotic signaling pathway
|
GO:2001242 |
72 |
0.414
|
|
|
|
protein secretion
|
GO:0009306 |
98 |
0.414
|
|
|
|
lymphocyte migration
|
GO:0072676 |
28 |
0.413
|
|
|
|
regulation of stress activated protein kinase signaling cascade
|
GO:0070302 |
85 |
0.408
|
|
|
|
regulation of t cell mediated immunity
|
GO:0002709 |
18 |
0.406
|
|
|
|
t cell cytokine production
|
GO:0002369 |
12 |
0.405
|
|
|
|
protein heterooligomerization
|
GO:0051291 |
16 |
0.403
|
Rat |
|
|
positive regulation of transferase activity
|
GO:0051347 |
227 |
0.400
|
|
|
|
positive regulation of jak stat cascade
|
GO:0046427 |
35 |
0.393
|
|
|
|
peptidyl tyrosine modification
|
GO:0018212 |
170 |
0.388
|
|
|
|
interferon gamma production
|
GO:0032609 |
39 |
0.383
|
|
|
|
transmission of nerve impulse
|
GO:0019226 |
11 |
0.381
|
|
|
|
t cell receptor signaling pathway
|
GO:0050852 |
21 |
0.378
|
|
|
|
positive regulation of transcription regulatory region dna binding
|
GO:2000679 |
8 |
0.377
|
|
|
|
regulation of proteolysis
|
GO:0030162 |
293 |
0.376
|
Human |
|
|
lymphocyte mediated immunity
|
GO:0002449 |
48 |
0.372
|
|
|
|
regulation of extrinsic apoptotic signaling pathway in absence of ligand
|
GO:2001239 |
20 |
0.370
|
|
|
|
negative regulation of cell proliferation
|
GO:0008285 |
228 |
0.362
|
|
|
|
necroptotic signaling pathway
|
GO:0097527 |
6 |
0.359
|
|
|
|
response to other organism
|
GO:0051707 |
261 |
0.358
|
|
|
|
positive regulation of protein k63 linked ubiquitination
|
GO:1902523 |
1 |
0.354
|
Human |
|
|
cellular response to lipoteichoic acid
|
GO:0071223 |
3 |
0.351
|
|
|
|
t cell mediated immunity
|
GO:0002456 |
25 |
0.341
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.340
|
|
|
|
regulation of interleukin 6 production
|
GO:0032675 |
37 |
0.339
|
|
|
|
positive regulation of interleukin 6 production
|
GO:0032755 |
21 |
0.339
|
|
|
|
mature natural killer cell chemotaxis
|
GO:0035782 |
1 |
0.334
|
|
|
|
regulation of lymphocyte differentiation
|
GO:0045619 |
22 |
0.331
|
|
|
|
positive regulation of t cell proliferation
|
GO:0042102 |
33 |
0.327
|
|
|
|
negative regulation of sequence specific dna binding transcription factor activity
|
GO:0043433 |
89 |
0.323
|
|
|
|
negative regulation of t cell cytokine production
|
GO:0002725 |
4 |
0.322
|
|
|
|
regulation of natural killer cell apoptotic process
|
GO:0070247 |
1 |
0.321
|
Human |
|
|
transmembrane transport
|
GO:0055085 |
399 |
0.319
|
|
|
|
modification dependent macromolecule catabolic process
|
GO:0043632 |
212 |
0.319
|
Human |
|
|
positive regulation of wnt signaling pathway
|
GO:0030177 |
54 |
0.315
|
Human |
|
|
regulation of intracellular protein transport
|
GO:0033157 |
123 |
0.314
|
|
|
|
defense response to gram positive bacterium
|
GO:0050830 |
29 |
0.308
|
|
|
|
positive regulation of t helper 1 type immune response
|
GO:0002827 |
4 |
0.307
|
|
|
|
positive regulation of erk1 and erk2 cascade
|
GO:0070374 |
75 |
0.306
|
|
|
|
regulation of peptidyl threonine phosphorylation
|
GO:0010799 |
15 |
0.303
|
|
|
|
neurological system process
|
GO:0050877 |
163 |
0.303
|
|
|
|
positive regulation of intracellular protein transport
|
GO:0090316 |
76 |
0.303
|
|
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
244 |
0.299
|
Human |
|
|
response to organonitrogen compound
|
GO:0010243 |
156 |
0.297
|
|
|
|
regulation of t cell activation
|
GO:0050863 |
77 |
0.293
|
|
|
|
regulation of transcription factor import into nucleus
|
GO:0042990 |
39 |
0.290
|
|
|
|
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002460 |
40 |
0.290
|
|
|
|
positive regulation of interleukin 1 beta secretion
|
GO:0050718 |
11 |
0.288
|
|
|
|
positive regulation of protein binding
|
GO:0032092 |
24 |
0.283
|
|
|
|
peptidyl threonine modification
|
GO:0018210 |
45 |
0.283
|
|
|
|
modification dependent protein catabolic process
|
GO:0019941 |
209 |
0.279
|
Human |
|
|
positive regulation of map kinase activity
|
GO:0043406 |
80 |
0.278
|
|
|
|
positive regulation of cd8 positive alpha beta t cell proliferation
|
GO:2000566 |
1 |
0.275
|
|
|
|
establishment of protein localization to organelle
|
GO:0072594 |
172 |
0.273
|
|
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
411 |
0.272
|
|
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
379 |
0.271
|
Human |
|
|
immune response regulating cell surface receptor signaling pathway
|
GO:0002768 |
51 |
0.266
|
|
|
|
regulation of immunoglobulin production
|
GO:0002637 |
4 |
0.265
|
|
|
|
positive regulation of nik nf kappab signaling
|
GO:1901224 |
10 |
0.261
|
|
|
|
regulation of leukocyte mediated immunity
|
GO:0002703 |
38 |
0.261
|
|
|
|
response to peptide
|
GO:1901652 |
65 |
0.258
|
|
|
|
response to mechanical stimulus
|
GO:0009612 |
51 |
0.258
|
|
|
|
regulation of t cell cytokine production
|
GO:0002724 |
10 |
0.257
|
|
|
|
regulation of lymphocyte mediated immunity
|
GO:0002706 |
33 |
0.250
|
|
|
|
cellular response to interferon gamma
|
GO:0071346 |
24 |
0.247
|
|
|
|
tnfsf11 mediated signaling pathway
|
GO:0071847 |
2 |
0.246
|
|
|
|
interleukin 12 production
|
GO:0032615 |
15 |
0.244
|
|
|
|
alpha beta t cell activation
|
GO:0046631 |
15 |
0.238
|
|
|
|
regulation of cysteine type endopeptidase activity
|
GO:2000116 |
127 |
0.236
|
Human |
|
|
protein linear polyubiquitination
|
GO:0097039 |
5 |
0.234
|
Human |
|
|
regulation of interferon beta production
|
GO:0032648 |
22 |
0.233
|
|
|
|
regulation of phosphatase activity
|
GO:0010921 |
81 |
0.228
|
|
|
|
regulation of circadian sleep wake cycle
|
GO:0042749 |
2 |
0.221
|
|
|
|
regulation of transmembrane transport
|
GO:0034762 |
139 |
0.218
|
|
|
|
leukocyte activation involved in immune response
|
GO:0002366 |
30 |
0.217
|
|
|
|
negative regulation of lymphocyte activation
|
GO:0051250 |
24 |
0.216
|
|
|
|
response to interferon gamma
|
GO:0034341 |
39 |
0.216
|
|
|
|
regulation of canonical wnt signaling pathway
|
GO:0060828 |
88 |
0.214
|
Human |
|
|
regulation of chemokine production
|
GO:0032642 |
31 |
0.212
|
|
|
|
regulation of response to external stimulus
|
GO:0032101 |
222 |
0.211
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
183 |
0.211
|
|
|
|
regulation of t helper 1 type immune response
|
GO:0002825 |
5 |
0.209
|
|
|
|
purine ribonucleoside metabolic process
|
GO:0046128 |
437 |
0.207
|
|
|
|
regulation of map kinase activity
|
GO:0043405 |
108 |
0.206
|
|
|
|
regulation of oxidoreductase activity
|
GO:0051341 |
43 |
0.202
|
|
|
|
lymphocyte differentiation
|
GO:0030098 |
35 |
0.201
|
|
|
|
negative regulation of secretion by cell
|
GO:1903531 |
52 |
0.200
|
|
|
|
defense response to bacterium
|
GO:0042742 |
63 |
0.198
|
|
|
|
regulation of mitotic cell cycle
|
GO:0007346 |
189 |
0.196
|
|
|
|
regulation of cytokine mediated signaling pathway
|
GO:0001959 |
41 |
0.192
|
|
|
|
positive regulation of cdc42 gtpase activity
|
GO:0043089 |
6 |
0.192
|
|
|
|
positive regulation of t cell activation
|
GO:0050870 |
54 |
0.192
|
|
|
|
positive regulation of proteolysis
|
GO:0045862 |
142 |
0.191
|
|
|
|
negative regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043154 |
46 |
0.189
|
Human |
|
|
positive regulation of lymphocyte activation
|
GO:0051251 |
73 |
0.187
|
|
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
331 |
0.183
|
|
|
|
positive regulation of protein monoubiquitination
|
GO:1902527 |
1 |
0.182
|
Human |
|
|
positive regulation of lymphocyte mediated immunity
|
GO:0002708 |
23 |
0.181
|
|
|
|
defense response to virus
|
GO:0051607 |
71 |
0.180
|
|
|
|
dephosphorylation
|
GO:0016311 |
209 |
0.177
|
|
|
|
detection of stimulus
|
GO:0051606 |
85 |
0.177
|
|
|
|
positive regulation of phosphatase activity
|
GO:0010922 |
14 |
0.176
|
|
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.176
|
Human |
|
|
positive regulation of nf kappab import into nucleus
|
GO:0042346 |
13 |
0.175
|
|
|
|
secretion
|
GO:0046903 |
254 |
0.171
|
|
|
|
negative regulation of cell cycle
|
GO:0045786 |
193 |
0.170
|
|
|
|
positive regulation of gtp catabolic process
|
GO:0033126 |
166 |
0.165
|
|
|
|
activation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0006919 |
49 |
0.164
|
|
|
|
regulation of interleukin 13 biosynthetic process
|
GO:0045366 |
1 |
0.163
|
|
|
|
cell activation involved in immune response
|
GO:0002263 |
30 |
0.162
|
|
|
|
negative regulation of protein processing
|
GO:0010955 |
142 |
0.156
|
Human |
|
|
response to exogenous dsrna
|
GO:0043330 |
10 |
0.156
|
|
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
267 |
0.154
|
Mouse |
|
|
negative regulation of toll like receptor 3 signaling pathway
|
GO:0034140 |
2 |
0.150
|
|
|
|
protein processing
|
GO:0016485 |
226 |
0.150
|
Human |
|
|
positive regulation of leukocyte activation
|
GO:0002696 |
80 |
0.149
|
|
|
|
response to organic cyclic compound
|
GO:0014070 |
204 |
0.149
|
|
|
|
negative regulation of systemic arterial blood pressure
|
GO:0003085 |
1 |
0.149
|
|
|
|
regulation of multi organism process
|
GO:0043900 |
157 |
0.148
|
|
|
|
negative regulation of nf kappab transcription factor activity
|
GO:0032088 |
51 |
0.147
|
|
|
|
regulation of cd4 positive alpha beta t cell differentiation
|
GO:0043370 |
3 |
0.147
|
|
|
|
regulation of protein secretion
|
GO:0050708 |
86 |
0.146
|
|
|
|
negative regulation of cd4 positive alpha beta t cell proliferation
|
GO:2000562 |
1 |
0.146
|
|
|
|
regulation of nik nf kappab signaling
|
GO:1901222 |
11 |
0.145
|
|
|
|
reactive nitrogen species metabolic process
|
GO:2001057 |
3 |
0.144
|
|
|
|
t cell differentiation in thymus
|
GO:0033077 |
4 |
0.144
|
|
|
|
wnt signaling pathway
|
GO:0016055 |
156 |
0.144
|
Human |
|
|
negative regulation of mitotic cell cycle
|
GO:0045930 |
102 |
0.141
|
|
|
|
positive regulation of lymphocyte proliferation
|
GO:0050671 |
46 |
0.140
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
179 |
0.139
|
|
|
|
ribonucleoside triphosphate metabolic process
|
GO:0009199 |
412 |
0.137
|
|
|
|
negative regulation of transcription from rna polymerase ii promoter
|
GO:0000122 |
281 |
0.137
|
|
|
|
negative regulation of immune system process
|
GO:0002683 |
136 |
0.137
|
|
|
|
positive regulation of alpha beta t cell proliferation
|
GO:0046641 |
5 |
0.135
|
|
|
|
tissue morphogenesis
|
GO:0048729 |
96 |
0.130
|
|
|
|
t helper 1 type immune response
|
GO:0042088 |
8 |
0.129
|
|
|
|
neuronal action potential
|
GO:0019228 |
9 |
0.129
|
|
|
|
regulation of reactive oxygen species biosynthetic process
|
GO:1903426 |
3 |
0.127
|
|
|
|
release of cytoplasmic sequestered nf kappab
|
GO:0008588 |
4 |
0.127
|
|
|
|
regulation of binding
|
GO:0051098 |
111 |
0.126
|
|
|
|
regulation of cell migration
|
GO:0030334 |
289 |
0.126
|
|
|
|
purine ribonucleoside triphosphate catabolic process
|
GO:0009207 |
391 |
0.125
|
|
|
|
positive regulation of alpha beta t cell activation
|
GO:0046635 |
10 |
0.125
|
|
|
|
eosinophil chemotaxis
|
GO:0048245 |
8 |
0.123
|
|
|
|
endothelial cell apoptotic process
|
GO:0072577 |
26 |
0.121
|
|
|
|
response to nitric oxide
|
GO:0071731 |
4 |
0.120
|
|
|
|
purine nucleoside triphosphate catabolic process
|
GO:0009146 |
392 |
0.119
|
|
|
|
nucleotide catabolic process
|
GO:0009166 |
408 |
0.119
|
|
|
|
alpha beta t cell activation involved in immune response
|
GO:0002287 |
5 |
0.117
|
|
|
|
positive regulation of cd4 positive alpha beta t cell activation
|
GO:2000516 |
3 |
0.116
|
|
|
|
gtp metabolic process
|
GO:0046039 |
239 |
0.115
|
|
|
|
cd8 positive alpha beta t cell activation
|
GO:0036037 |
3 |
0.115
|
|
|
|
positive regulation of cytokine mediated signaling pathway
|
GO:0001961 |
12 |
0.113
|
|
|
|
regulation of rho protein signal transduction
|
GO:0035023 |
79 |
0.112
|
|
|
|
positive regulation of leukocyte proliferation
|
GO:0070665 |
48 |
0.111
|
|
|
|
intrinsic apoptotic signaling pathway in response to oxidative stress
|
GO:0008631 |
21 |
0.110
|
|
|
|
purine nucleoside triphosphate metabolic process
|
GO:0009144 |
412 |
0.109
|
|
|
|
morphogenesis of an epithelium
|
GO:0002009 |
60 |
0.108
|
|
|
|
membrane protein proteolysis
|
GO:0033619 |
38 |
0.108
|
|
|
|
negative regulation of proteolysis
|
GO:0045861 |
132 |
0.107
|
Human |
|
|
regulation of type i interferon production
|
GO:0032479 |
26 |
0.107
|
|
|
|
regulation of nucleobase containing compound transport
|
GO:0032239 |
7 |
0.105
|
|
|
|
negative regulation of g1 s transition of mitotic cell cycle
|
GO:2000134 |
29 |
0.103
|
|
|
|
regulation of ras gtpase activity
|
GO:0032318 |
128 |
0.103
|
|
|
|
negative regulation of cell cycle process
|
GO:0010948 |
121 |
0.103
|
|
|
|
regulation of t cell differentiation
|
GO:0045580 |
19 |
0.100
|
|
|
|
nucleocytoplasmic transport
|
GO:0006913 |
176 |
0.099
|
|
|
|
regulation of endothelial cell apoptotic process
|
GO:2000351 |
24 |
0.099
|
|
|
|
posttranscriptional regulation of gene expression
|
GO:0010608 |
213 |
0.099
|
|
|
|
response to abiotic stimulus
|
GO:0009628 |
336 |
0.097
|
|
|
|
neurogenesis
|
GO:0022008 |
169 |
0.097
|
|
|
|
protein homotrimerization
|
GO:0070207 |
9 |
0.096
|
|
|
|
regulation of cell cycle
|
GO:0051726 |
393 |
0.095
|
Human |
|
|
regulation of protein binding
|
GO:0043393 |
66 |
0.093
|
|
|
|
positive regulation of immune effector process
|
GO:0002699 |
40 |
0.093
|
|
|
|
nucleoside triphosphate metabolic process
|
GO:0009141 |
422 |
0.088
|
|
|
|
regulation of protein localization to nucleus
|
GO:1900180 |
85 |
0.087
|
|
|
|
positive regulation of intrinsic apoptotic signaling pathway
|
GO:2001244 |
28 |
0.085
|
|
|
|
interleukin 1 beta secretion
|
GO:0050702 |
15 |
0.083
|
|
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.083
|
Human |
|
|
inflammatory response
|
GO:0006954 |
79 |
0.082
|
|
|
|
response to reactive oxygen species
|
GO:0000302 |
61 |
0.082
|
|
|
|
production of molecular mediator of immune response
|
GO:0002440 |
37 |
0.082
|
|
|
|
positive regulation of lymphocyte migration
|
GO:2000403 |
16 |
0.081
|
|
|
|
multi organism metabolic process
|
GO:0044033 |
41 |
0.081
|
|
|
|
cellular response to oxidative stress
|
GO:0034599 |
85 |
0.080
|
|
|
|
response to uv
|
GO:0009411 |
73 |
0.080
|
|
|
|
type i interferon production
|
GO:0032606 |
27 |
0.079
|
|
|
|
regulation of t cell apoptotic process
|
GO:0070232 |
8 |
0.078
|
|
|
|
regulation of wnt signaling pathway
|
GO:0030111 |
123 |
0.077
|
Human |
|
|
ubiquitin dependent protein catabolic process
|
GO:0006511 |
206 |
0.077
|
Human |
|
|
positive regulation of secretion by cell
|
GO:1903532 |
108 |
0.076
|
|
|
|
positive regulation of peptidyl threonine phosphorylation
|
GO:0010800 |
9 |
0.076
|
|
|
|
regulation of protein transport
|
GO:0051223 |
213 |
0.076
|
|
|
|
positive regulation of dephosphorylation
|
GO:0035306 |
26 |
0.075
|
|
|
|
guanosine containing compound metabolic process
|
GO:1901068 |
244 |
0.075
|
|
|
|
regulation of dephosphorylation
|
GO:0035303 |
96 |
0.073
|
|
|
|
system process
|
GO:0003008 |
349 |
0.073
|
|
|
|
myoblast fusion
|
GO:0007520 |
1 |
0.073
|
|
|
|
negative regulation of leukocyte activation
|
GO:0002695 |
26 |
0.072
|
|
|
|
positive regulation of interleukin 4 biosynthetic process
|
GO:0045404 |
1 |
0.072
|
|
|
|
amide transport
|
GO:0042886 |
76 |
0.071
|
|
|
|
response to oxidative stress
|
GO:0006979 |
121 |
0.071
|
|
|
|
positive regulation of transport
|
GO:0051050 |
336 |
0.071
|
|
|
|
negative regulation of interleukin 1 beta production
|
GO:0032691 |
6 |
0.070
|
|
|
|
vitamin d metabolic process
|
GO:0042359 |
10 |
0.070
|
|
|
|
positive regulation of t cell differentiation
|
GO:0045582 |
11 |
0.070
|
|
|
|
regulation of response to biotic stimulus
|
GO:0002831 |
55 |
0.070
|
|
|
|
positive regulation of lymphocyte differentiation
|
GO:0045621 |
13 |
0.069
|
|
|
|
negative regulation of alpha beta t cell proliferation
|
GO:0046642 |
1 |
0.068
|
|
|
|
regulation of inflammatory response
|
GO:0050727 |
46 |
0.067
|
|
|
|
positive regulation of locomotion
|
GO:0040017 |
186 |
0.067
|
|
|
|
regulation of cellular component movement
|
GO:0051270 |
334 |
0.067
|
|
|
|
mitotic cell cycle
|
GO:0000278 |
326 |
0.066
|
|
|
|
lymphocyte activation involved in immune response
|
GO:0002285 |
20 |
0.066
|
|
|
|
regulation of nucleoside metabolic process
|
GO:0009118 |
209 |
0.066
|
|
|
|
proteasome mediated ubiquitin dependent protein catabolic process
|
GO:0043161 |
156 |
0.065
|
Human |
|
|
negative regulation of endopeptidase activity
|
GO:0010951 |
84 |
0.065
|
Human |
|
|
positive regulation of protein transport
|
GO:0051222 |
135 |
0.064
|
|
|
|
syncytium formation by plasma membrane fusion
|
GO:0000768 |
2 |
0.064
|
|
|
|
regulation of cdc42 protein signal transduction
|
GO:0032489 |
14 |
0.063
|
|
|
|
positive regulation of cell migration
|
GO:0030335 |
172 |
0.063
|
|
