Homo sapiens

347 known processes

BRCA1

breast cancer 1, early onset

(Aliases: IRIS,PSCP,RNF53,BRCC1,PNCA4,BROVCA1,BRCAI)

BRCA1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular response to dna damage stimulus GO:0006974 379 1.000
dna repair GO:0006281 198 1.000
g2 dna damage checkpoint GO:0031572 26 1.000
double strand break repair GO:0006302 101 1.000
response to radiation GO:0009314 151 1.000
covalent chromatin modification GO:0016569 254 1.000
response to ionizing radiation GO:0010212 65 1.000
double strand break repair via homologous recombination GO:0000724 50 1.000
dna integrity checkpoint GO:0031570 71 1.000
dna recombination GO:0006310 77 1.000
chromatin organization GO:0006325 351 1.000
dna damage checkpoint GO:0000077 68 1.000
histone modification GO:0016570 251 1.000
dna double strand break processing GO:0000729 10 1.000
regulation of cell cycle GO:0051726 393 1.000
dna damage response signal transduction by p53 class mediator GO:0030330 44 1.000
double strand break repair via single strand annealing GO:0045002 4 1.000
chromatin modification GO:0016568 298 1.000
negative regulation of cell death GO:0060548 345 1.000
mitotic dna integrity checkpoint GO:0044774 30 1.000
meiotic chromosome segregation GO:0045132 4 1.000
response to abiotic stimulus GO:0009628 336 1.000
negative regulation of cell cycle GO:0045786 193 1.000
mitotic dna damage checkpoint GO:0044773 28 1.000
histone acetylation GO:0016573 93 1.000
response to organic cyclic compound GO:0014070 204 1.000
signal transduction in response to dna damage GO:0042770 57 1.000
regulation of response to dna damage stimulus GO:2001020 94 1.000
negative regulation of mitotic cell cycle GO:0045930 102 1.000
cellular macromolecule catabolic process GO:0044265 380 0.999
regulation of mitotic cell cycle GO:0007346 189 0.999
g2 m transition of mitotic cell cycle GO:0000086 41 0.999
nuclear division GO:0000280 128 0.999
regulation of double strand break repair GO:2000779 22 0.999
mitotic cell cycle phase transition GO:0044772 162 0.999
intrinsic apoptotic signaling pathway GO:0097193 127 0.999
dna damage induced protein phosphorylation GO:0006975 5 0.999
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.998
recombinational repair GO:0000725 50 0.998
positive regulation of cellular component organization GO:0051130 376 0.998
histone h4 acetylation GO:0043967 47 0.998
regulation of dna metabolic process GO:0051052 153 0.998
positive regulation of response to dna damage stimulus GO:2001022 43 0.998
dna dependent dna replication GO:0006261 44 0.998
mitotic cell cycle checkpoint GO:0007093 68 0.998
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.998
dna replication GO:0006260 116 0.998
Mouse
immune system development GO:0002520 195 0.997
mitotic cell cycle GO:0000278 326 0.997
cellular response to endogenous stimulus GO:0071495 336 0.997
nucleotide excision repair GO:0006289 31 0.997
cellular response to abiotic stimulus GO:0071214 117 0.996
regulation of cellular response to stress GO:0080135 244 0.996
regulation of dna repair GO:0006282 47 0.996
apoptotic signaling pathway GO:0097190 268 0.996
somatic diversification of immunoglobulins involved in immune response GO:0002208 3 0.996
regulation of meiotic cell cycle GO:0051445 4 0.995
meiosis i GO:0007127 4 0.995
negative regulation of cell cycle process GO:0010948 121 0.994
positive regulation of cell cycle GO:0045787 140 0.992
dna catabolic process GO:0006308 49 0.991
negative regulation of cell proliferation GO:0008285 228 0.991
non recombinational repair GO:0000726 14 0.990
positive regulation of organelle organization GO:0010638 195 0.990
chromosome segregation GO:0007059 114 0.989
response to organonitrogen compound GO:0010243 156 0.988
cell cycle g2 m phase transition GO:0044839 43 0.987
positive regulation of dna metabolic process GO:0051054 73 0.987
regulation of cell cycle phase transition GO:1901987 126 0.987
blastocyst development GO:0001824 3 0.986
anatomical structure homeostasis GO:0060249 100 0.985
somatic recombination of immunoglobulin gene segments GO:0016447 4 0.985
cell cycle checkpoint GO:0000075 117 0.983
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.983
nucleoside monophosphate metabolic process GO:0009123 191 0.982
mismatch repair GO:0006298 15 0.981
cellular response to ionizing radiation GO:0071479 32 0.980
mitotic cell cycle process GO:1903047 286 0.975
embryo development GO:0009790 123 0.972
Mouse
ubiquitin dependent protein catabolic process GO:0006511 206 0.969
peptidyl lysine acetylation GO:0018394 101 0.969
regulation of cell cycle process GO:0010564 266 0.969
signal transduction by p53 class mediator GO:0072331 72 0.968
double strand break repair via nonhomologous end joining GO:0006303 10 0.967
negative regulation of apoptotic process GO:0043066 316 0.966
modification dependent macromolecule catabolic process GO:0043632 212 0.966
cell activation involved in immune response GO:0002263 30 0.965
somatic recombination of immunoglobulin genes involved in immune response GO:0002204 3 0.964
internal protein amino acid acetylation GO:0006475 101 0.962
dna catabolic process exonucleolytic GO:0000738 17 0.961
regulation of double strand break repair via homologous recombination GO:0010569 11 0.959
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.956
reciprocal meiotic recombination GO:0007131 4 0.952
response to purine containing compound GO:0014074 40 0.950
negative regulation of programmed cell death GO:0043069 321 0.949
cell cycle arrest GO:0007050 71 0.948
embryo development ending in birth or egg hatching GO:0009792 34 0.946
Mouse
meiotic nuclear division GO:0007126 10 0.946
response to caffeine GO:0031000 3 0.944
cellular response to radiation GO:0071478 65 0.942
female gamete generation GO:0007292 2 0.941
immune effector process GO:0002252 159 0.941
cell type specific apoptotic process GO:0097285 125 0.936
regulation of endopeptidase activity GO:0052548 170 0.935
regulation of mitotic cell cycle phase transition GO:1901990 118 0.935
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 37 0.932
meiotic cell cycle GO:0051321 13 0.930
response to oxygen containing compound GO:1901700 369 0.925
dna conformation change GO:0071103 113 0.924
mitotic g2 dna damage checkpoint GO:0007095 7 0.924
dna geometric change GO:0032392 32 0.923
chordate embryonic development GO:0043009 34 0.920
Mouse
negative regulation of dna metabolic process GO:0051053 57 0.918
positive regulation of cell proliferation GO:0008284 301 0.913
isotype switching GO:0045190 3 0.908
protein modification by small protein conjugation GO:0032446 342 0.906
oocyte maturation GO:0001556 1 0.898
response to gamma radiation GO:0010332 14 0.893
cell cycle phase transition GO:0044770 173 0.889
response to hormone GO:0009725 175 0.876
organelle fission GO:0048285 149 0.872
cell cycle g1 s phase transition GO:0044843 80 0.871
response to steroid hormone GO:0048545 80 0.866
leukocyte activation GO:0045321 164 0.860
oocyte development GO:0048599 1 0.856
telomere capping GO:0016233 5 0.855
sister chromatid cohesion GO:0007062 24 0.851
replication fork processing GO:0031297 13 0.849
somatic diversification of immune receptors via somatic mutation GO:0002566 1 0.847
regulation of kinase activity GO:0043549 314 0.844
mitotic recombination GO:0006312 8 0.839
positive regulation of cell death GO:0010942 263 0.839
regulation of proteolysis GO:0030162 293 0.838
oogenesis GO:0048477 2 0.838
hemopoiesis GO:0030097 180 0.838
leukocyte differentiation GO:0002521 98 0.835
blood vessel development GO:0001568 172 0.833
positive regulation of meiotic cell cycle GO:0051446 2 0.832
adaptive immune response GO:0002250 49 0.831
response to alkaloid GO:0043279 20 0.823
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.821
regulation of g2 m transition of mitotic cell cycle GO:0010389 20 0.820
telomere maintenance GO:0000723 32 0.810
protein catabolic process GO:0030163 325 0.803
embryonic morphogenesis GO:0048598 85 0.802
organ morphogenesis GO:0009887 147 0.801
lymphocyte activation GO:0046649 133 0.799
dna duplex unwinding GO:0032508 30 0.783
cellular protein catabolic process GO:0044257 261 0.781
regulation of protein ubiquitination GO:0031396 95 0.780
neuron apoptotic process GO:0051402 39 0.780
cell activation GO:0001775 213 0.778
immune response GO:0006955 307 0.771
response to nitrogen compound GO:1901698 184 0.755
oocyte differentiation GO:0009994 2 0.743
meiotic cell cycle process GO:1903046 8 0.742
cell development GO:0048468 328 0.732
positive regulation of programmed cell death GO:0043068 249 0.721
protein oligomerization GO:0051259 173 0.721
protein ubiquitination GO:0016567 314 0.718
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.711
blood vessel morphogenesis GO:0048514 162 0.711
negative regulation of organelle organization GO:0010639 126 0.708
negative regulation of cell cycle phase transition GO:1901988 89 0.706
anatomical structure formation involved in morphogenesis GO:0048646 284 0.702
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.701
positive regulation of cell cycle process GO:0090068 106 0.697
modification dependent protein catabolic process GO:0019941 209 0.696
cellular response to external stimulus GO:0071496 111 0.692
lipid biosynthetic process GO:0008610 177 0.690
gland development GO:0048732 48 0.682
regulation of dna replication GO:0006275 68 0.682
ribonucleoside monophosphate catabolic process GO:0009158 158 0.681
regulation of epithelial cell proliferation GO:0050678 113 0.679
response to uv GO:0009411 73 0.679
positive regulation of developmental process GO:0051094 314 0.678
regulation of histone modification GO:0031056 47 0.665
cellular amino acid metabolic process GO:0006520 116 0.665
protein polyubiquitination GO:0000209 110 0.661
somatic diversification of immunoglobulins GO:0016445 6 0.657
amine metabolic process GO:0009308 44 0.651
positive regulation of dna damage response signal transduction by p53 class mediator GO:0043517 8 0.644
microtubule based process GO:0007017 210 0.643
Mouse
telomere maintenance via recombination GO:0000722 4 0.641
positive regulation of chromosome organization GO:2001252 41 0.638
proteasomal protein catabolic process GO:0010498 176 0.637
regulation of protein kinase activity GO:0045859 289 0.631
dna dependent dna replication maintenance of fidelity GO:0045005 14 0.628
methylation GO:0032259 106 0.628
signal transduction involved in mitotic cell cycle checkpoint GO:0072413 13 0.626
regulation of chromosome segregation GO:0051983 44 0.622
positive regulation of mitotic cell cycle GO:0045931 60 0.609
male meiosis GO:0007140 1 0.596
regulation of gene expression epigenetic GO:0040029 73 0.594
Mouse
negative regulation of dna replication GO:0008156 29 0.594
regulation of neuron apoptotic process GO:0043523 35 0.588
peptidyl serine modification GO:0018209 106 0.578
b cell activation GO:0042113 33 0.574
peptidyl lysine modification GO:0018205 144 0.571
maintenance of dna repeat elements GO:0043570 4 0.570
purine nucleoside monophosphate metabolic process GO:0009126 186 0.561
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.553
dna damage response signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 11 0.550
interstrand cross link repair GO:0036297 3 0.548
intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator GO:0042771 23 0.547
meiotic chromosome separation GO:0051307 3 0.546
regulation of cell activation GO:0050865 125 0.540
macromolecule methylation GO:0043414 97 0.526
protein acylation GO:0043543 138 0.524
regulation of chromatin modification GO:1903308 51 0.524
centrosome cycle GO:0007098 32 0.522
Mouse
regulation of signal transduction by p53 class mediator GO:1901796 26 0.518
purine nucleoside monophosphate catabolic process GO:0009128 158 0.515
cell division GO:0051301 168 0.513
growth GO:0040007 202 0.510
histone lysine methylation GO:0034968 50 0.508
protein methylation GO:0006479 74 0.499
protein alkylation GO:0008213 74 0.490
protein deubiquitination GO:0016579 79 0.463
response to estrogen GO:0043627 47 0.459
signal transduction involved in mitotic dna integrity checkpoint GO:1902403 13 0.450
ribonucleoside monophosphate metabolic process GO:0009161 187 0.447
cellular ketone metabolic process GO:0042180 80 0.447
cell morphogenesis involved in differentiation GO:0000904 144 0.443
cellular response to organonitrogen compound GO:0071417 124 0.440
mitotic g2 m transition checkpoint GO:0044818 9 0.439
regulation of transferase activity GO:0051338 355 0.432
regulation of cellular amine metabolic process GO:0033238 11 0.422
membrane organization GO:0061024 292 0.418
reproduction GO:0000003 63 0.405
mitotic nuclear division GO:0007067 119 0.402
vasculature development GO:0001944 181 0.402
positive regulation of proteolysis GO:0045862 142 0.400
reciprocal dna recombination GO:0035825 4 0.398
thymocyte apoptotic process GO:0070242 2 0.398
signal transduction by phosphorylation GO:0023014 297 0.393
regulation of mononuclear cell proliferation GO:0032944 65 0.392
positive regulation of apoptotic process GO:0043065 246 0.391
protein acetylation GO:0006473 116 0.389
lymphocyte proliferation GO:0046651 70 0.385
telomere organization GO:0032200 33 0.385
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.382
intra s dna damage checkpoint GO:0031573 4 0.377
atp metabolic process GO:0046034 176 0.370
regulation of protein catabolic process GO:0042176 155 0.370
glycosyl compound catabolic process GO:1901658 413 0.367
leukocyte mediated immunity GO:0002443 59 0.364
regulation of chromosome organization GO:0033044 103 0.360
chromatin silencing GO:0006342 12 0.360
cellular response to organic cyclic compound GO:0071407 127 0.357
single organism cellular localization GO:1902580 332 0.354
cell morphogenesis GO:0000902 296 0.350
mitotic g1 dna damage checkpoint GO:0031571 17 0.350
positive regulation of catabolic process GO:0009896 310 0.346
response to extracellular stimulus GO:0009991 85 0.340
Rat
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.336
dna damage response signal transduction resulting in transcription GO:0042772 12 0.335
regulation of dna recombination GO:0000018 23 0.333
immunoglobulin production GO:0002377 12 0.331
mitochondrion organization GO:0007005 156 0.327
somatic cell dna recombination GO:0016444 6 0.306
protein processing GO:0016485 226 0.303
regulation of cell cycle g2 m phase transition GO:1902749 22 0.299
cell growth GO:0016049 160 0.297
positive regulation of protein phosphorylation GO:0001934 313 0.295
negative regulation of cellular protein metabolic process GO:0032269 353 0.292
response to inorganic substance GO:0010035 127 0.288
negative regulation of mitotic metaphase anaphase transition GO:0045841 17 0.287
negative regulation of phosphorus metabolic process GO:0010563 267 0.284
internal peptidyl lysine acetylation GO:0018393 97 0.280
production of molecular mediator of immune response GO:0002440 37 0.268
digestive tract development GO:0048565 75 0.263
atp catabolic process GO:0006200 157 0.263
regulation of mitotic sister chromatid segregation GO:0033047 27 0.258
lymphocyte mediated immunity GO:0002449 48 0.255
response to lipid GO:0033993 206 0.253
rna catabolic process GO:0006401 71 0.249
positive regulation of transferase activity GO:0051347 227 0.246
multicellular organism reproduction GO:0032504 42 0.246
regulation of protein maturation GO:1903317 150 0.244
negative regulation of g1 s transition of mitotic cell cycle GO:2000134 29 0.243
regionalization GO:0003002 29 0.238
tube development GO:0035295 125 0.237
peptidyl serine phosphorylation GO:0018105 101 0.236
nucleoside triphosphate catabolic process GO:0009143 394 0.236
response to oxidative stress GO:0006979 121 0.233
response to nutrient levels GO:0031667 81 0.225
Rat
immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 5 0.222
regulation of mitosis GO:0007088 63 0.221
regulation of cellular ketone metabolic process GO:0010565 50 0.220
dna catabolic process endonucleolytic GO:0000737 37 0.219
protein localization to organelle GO:0033365 280 0.218
cellular response to nitrogen compound GO:1901699 144 0.213
chromosome separation GO:0051304 23 0.213
mrna metabolic process GO:0016071 175 0.212
negative regulation of t cell apoptotic process GO:0070233 4 0.207
positive regulation of kinase activity GO:0033674 204 0.207
response to reactive oxygen species GO:0000302 61 0.205
regulation of protein autophosphorylation GO:0031952 15 0.198
dna biosynthetic process GO:0071897 40 0.197
mitotic dna replication checkpoint GO:0033314 2 0.196
tube morphogenesis GO:0035239 95 0.196
single organism membrane organization GO:0044802 268 0.195
epithelium development GO:0060429 227 0.192
intracellular receptor signaling pathway GO:0030522 104 0.192
response to alcohol GO:0097305 64 0.192
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.191
cellular response to growth factor stimulus GO:0071363 197 0.191
dephosphorylation GO:0016311 209 0.189
purine nucleoside triphosphate catabolic process GO:0009146 392 0.188
nuclear import GO:0051170 106 0.187
sister chromatid segregation GO:0000819 54 0.186
intracellular protein transport GO:0006886 270 0.184
posttranscriptional regulation of gene expression GO:0010608 213 0.183
b cell mediated immunity GO:0019724 10 0.180
immunoglobulin mediated immune response GO:0016064 10 0.176
signal transduction involved in dna damage checkpoint GO:0072422 15 0.173
microtubule cytoskeleton organization GO:0000226 176 0.169
Mouse
pattern specification process GO:0007389 43 0.168
hematopoietic or lymphoid organ development GO:0048534 186 0.168
multicellular organismal aging GO:0010259 3 0.168
cellular response to hormone stimulus GO:0032870 125 0.166
segmentation GO:0035282 4 0.165
leukocyte activation involved in immune response GO:0002366 30 0.162
signal transduction involved in mitotic dna damage checkpoint GO:1902402 13 0.161
cellular response to extracellular stimulus GO:0031668 72 0.159
gene conversion GO:0035822 1 0.158
regulation of leukocyte activation GO:0002694 115 0.155
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 40 0.153
aging GO:0007568 66 0.153
negative regulation of phosphate metabolic process GO:0045936 267 0.151
reproductive system development GO:0061458 56 0.151
multicellular organismal reproductive process GO:0048609 40 0.148
base excision repair GO:0006284 21 0.145
centrosome organization GO:0051297 58 0.141
Mouse
protein autophosphorylation GO:0046777 123 0.140
cell substrate adhesion GO:0031589 132 0.139
g1 s transition of mitotic cell cycle GO:0000082 78 0.138
negative regulation of cell division GO:0051782 31 0.137
sex determination GO:0007530 3 0.136
negative regulation of cell size GO:0045792 3 0.136
regulation of mitotic sister chromatid separation GO:0010965 27 0.135
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.134
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.133
head development GO:0060322 108 0.132
Rat
cell projection organization GO:0030030 252 0.129
cell cycle dna replication GO:0044786 11 0.126
ras protein signal transduction GO:0007265 73 0.126
negative regulation of protein processing GO:0010955 142 0.125
regulation of lymphocyte activation GO:0051249 103 0.124
circulatory system development GO:0072359 262 0.120
reproductive process GO:0022414 106 0.119
single organism reproductive process GO:0044702 98 0.119
regulation of cellular amino acid metabolic process GO:0006521 6 0.118
cellular response to steroid hormone stimulus GO:0071383 37 0.115
in utero embryonic development GO:0001701 8 0.113
regulation of protein stability GO:0031647 87 0.112
negative regulation of hydrolase activity GO:0051346 182 0.111
negative regulation of g2 m transition of mitotic cell cycle GO:0010972 9 0.110
nervous system development GO:0007399 293 0.109
Rat
cell fate commitment GO:0045165 27 0.106
regulation of apoptotic signaling pathway GO:2001233 175 0.106
myeloid cell differentiation GO:0030099 117 0.106
response to hypoxia GO:0001666 96 0.105
ribonucleotide catabolic process GO:0009261 405 0.103
negative regulation of developmental process GO:0051093 247 0.102
peptidyl tyrosine phosphorylation GO:0018108 170 0.101
regulation of viral process GO:0050792 103 0.100
regulation of sister chromatid segregation GO:0033045 27 0.098
response to oxygen levels GO:0070482 100 0.097
protein targeting GO:0006605 187 0.097
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.095
male gonad development GO:0008584 23 0.094
positive regulation of cellular catabolic process GO:0031331 284 0.093
viral process GO:0016032 146 0.093
phosphatidylinositol 3 phosphate biosynthetic process GO:0036092 3 0.092
negative regulation of gene expression epigenetic GO:0045814 19 0.090
negative regulation of protein maturation GO:1903318 142 0.090
nuclear transport GO:0051169 179 0.090
protein homooligomerization GO:0051260 100 0.087
sexual reproduction GO:0019953 37 0.086
lymphocyte activation involved in immune response GO:0002285 20 0.085
positive regulation of cell differentiation GO:0045597 211 0.085
enzyme linked receptor protein signaling pathway GO:0007167 303 0.085
cellular response to alkaloid GO:0071312 11 0.084
histone h2a phosphorylation GO:1990164 3 0.083
cellular response to lipid GO:0071396 127 0.082
positive regulation of phosphorylation GO:0042327 394 0.082
tissue homeostasis GO:0001894 63 0.082
epithelial cell differentiation GO:0030855 141 0.081
negative regulation of multicellular organismal process GO:0051241 317 0.080
regulation of protein acetylation GO:1901983 25 0.079
cellular amine metabolic process GO:0044106 41 0.079
nucleoside phosphate catabolic process GO:1901292 412 0.079
cellular component morphogenesis GO:0032989 314 0.078
ribosome assembly GO:0042255 9 0.078
dna synthesis involved in dna repair GO:0000731 6 0.078
regulation of establishment of protein localization GO:0070201 242 0.077
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 35 0.077
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 0.077
regulation of peptidase activity GO:0052547 180 0.076
somatic diversification of immune receptors GO:0002200 8 0.073
cell fate determination GO:0001709 3 0.073
regulation of protein processing GO:0070613 150 0.073
response to estradiol GO:0032355 23 0.072
Rat
purine ribonucleoside metabolic process GO:0046128 437 0.070
histone h3 k4 methylation GO:0051568 27 0.068
cellular lipid metabolic process GO:0044255 303 0.068
negative regulation of protein metabolic process GO:0051248 391 0.066
positive regulation of hydrolase activity GO:0051345 331 0.066
small gtpase mediated signal transduction GO:0007264 78 0.065
regulation of cell division GO:0051302 116 0.065
t cell apoptotic process GO:0070231 12 0.065
signal transduction involved in mitotic g1 dna damage checkpoint GO:0072431 10 0.063
epithelial cell proliferation GO:0050673 128 0.063
defense response GO:0006952 315 0.062
regulation of protein binding GO:0043393 66 0.061
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.060
regulation of cell differentiation GO:0045595 393 0.060
establishment of protein localization to organelle GO:0072594 172 0.060
dna packaging GO:0006323 77 0.059
regeneration GO:0031099 4 0.058
somatic hypermutation of immunoglobulin genes GO:0016446 1 0.058
gene silencing GO:0016458 49 0.057
response to light stimulus GO:0009416 87 0.056
neurogenesis GO:0022008 169 0.056
ribonucleoside catabolic process GO:0042454 406 0.055
developmental process involved in reproduction GO:0003006 66 0.055
purine nucleoside triphosphate metabolic process GO:0009144 412 0.055
purine nucleotide catabolic process GO:0006195 405 0.055
t cell activation GO:0042110 99 0.054
development of primary male sexual characteristics GO:0046546 23 0.054
regulation of chromatin organization GO:1902275 56 0.052
homeostasis of number of cells GO:0048872 40 0.052
negative regulation of cellular protein catabolic process GO:1903363 38 0.051
nucleoside monophosphate catabolic process GO:0009125 159 0.050
multi organism reproductive process GO:0044703 54 0.049
brain development GO:0007420 97 0.049
Rat
positive regulation of cellular component biogenesis GO:0044089 158 0.048
cell aging GO:0007569 52 0.048
chromosome condensation GO:0030261 15 0.047
reactive oxygen species metabolic process GO:0072593 75 0.047
regulation of histone acetylation GO:0035065 19 0.047
cellular response to oxygen levels GO:0071453 55 0.046
purine nucleoside catabolic process GO:0006152 398 0.046
cell part morphogenesis GO:0032990 137 0.046
negative regulation of epithelial cell proliferation GO:0050680 48 0.046
negative regulation of apoptotic signaling pathway GO:2001234 97 0.045
regulation of metaphase anaphase transition of cell cycle GO:1902099 26 0.045
determination of adult lifespan GO:0008340 2 0.044
gamete generation GO:0007276 25 0.044
neuron development GO:0048666 113 0.044
developmental growth GO:0048589 48 0.043
metaphase anaphase transition of mitotic cell cycle GO:0007091 21 0.043
embryonic organ development GO:0048568 36 0.043
multicellular organismal homeostasis GO:0048871 67 0.042
regulation of mitotic metaphase anaphase transition GO:0030071 26 0.042
single organism nuclear import GO:1902593 104 0.041
male gamete generation GO:0048232 22 0.041
regulation of protein serine threonine kinase activity GO:0071900 179 0.040
heart development GO:0007507 95 0.040
positive regulation of histone modification GO:0031058 29 0.040
regulation of phosphatase activity GO:0010921 81 0.039
regulation of protein localization GO:0032880 296 0.039
negative regulation of phosphorylation GO:0042326 174 0.039
mrna catabolic process GO:0006402 56 0.039
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.039
negative regulation of proteolysis GO:0045861 132 0.039
protein maturation GO:0051604 233 0.039
regulation of multi organism process GO:0043900 157 0.038
cardiovascular system development GO:0072358 262 0.038
mitotic g1 s transition checkpoint GO:0044819 17 0.037
cellular response to uv GO:0034644 32 0.037
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.037
system process GO:0003008 349 0.037
b cell differentiation GO:0030183 6 0.036
positive regulation of proteasomal protein catabolic process GO:1901800 35 0.035

BRCA1 disease predictions

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 155 1.000
disease of cellular proliferation DOID:14566 174 1.000
cancer DOID:162 167 1.000
breast cancer DOID:1612 21 0.999
thoracic cancer DOID:5093 21 0.999
organ system cancer DOID:0050686 164 0.999
aplastic anemia DOID:12449 30 0.992
bone marrow disease DOID:4961 31 0.992
anemia DOID:2355 55 0.992
hematopoietic system disease DOID:74 100 0.992
congenital hypoplastic anemia DOID:1342 26 0.513
endocrine gland cancer DOID:170 26 0.286
pancreatic cancer DOID:1793 8 0.286
reproductive organ cancer DOID:193 23 0.185
immune system cancer DOID:0060083 36 0.059
hematologic cancer DOID:2531 36 0.059