Homo sapiens

118 known processes

CASP8AP2

caspase 8 associated protein 2

(Aliases: KIAA1315,FLASH,FLJ11208,CED-4,RIP25)

CASP8AP2 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
cellular response to dna damage stimulus GO:0006974 379 0.892
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.638
post embryonic development GO:0009791 2 0.609
regulation of cellular amine metabolic process GO:0033238 11 0.468
positive regulation of cellular amine metabolic process GO:0033240 7 0.403
mitotic cell cycle process GO:1903047 286 0.384
positive regulation of proteolysis GO:0045862 142 0.373
regulation of cellular amino acid metabolic process GO:0006521 6 0.373
cellular amino acid metabolic process GO:0006520 116 0.340
hemopoiesis GO:0030097 180 0.335
regulation of proteolysis GO:0030162 293 0.289
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.289
negative regulation of apoptotic process GO:0043066 316 0.267
amine metabolic process GO:0009308 44 0.254
hematopoietic or lymphoid organ development GO:0048534 186 0.247
regulation of cellular ketone metabolic process GO:0010565 50 0.235
negative regulation of cell cycle phase transition GO:1901988 89 0.222
negative regulation of cell death GO:0060548 345 0.218
anatomical structure formation involved in morphogenesis GO:0048646 284 0.216
cellular ketone metabolic process GO:0042180 80 0.205
positive regulation of hydrolase activity GO:0051345 331 0.194
regulation of apoptotic signaling pathway GO:2001233 175 0.194
cellular macromolecule catabolic process GO:0044265 380 0.178
cellular amine metabolic process GO:0044106 41 0.163
response to abiotic stimulus GO:0009628 336 0.152
apoptotic signaling pathway GO:0097190 268 0.147
response to oxygen containing compound GO:1901700 369 0.145
maintenance of location GO:0051235 112 0.136
mitotic cell cycle GO:0000278 326 0.135
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.133
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 49 0.133
mitotic dna integrity checkpoint GO:0044774 30 0.132
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 42 0.132
ameboidal type cell migration GO:0001667 135 0.129
regulation of endopeptidase activity GO:0052548 170 0.129
negative regulation of mitotic cell cycle GO:0045930 102 0.121
regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 24 0.119
regulation of cellular response to stress GO:0080135 244 0.118
regulation of intracellular transport GO:0032386 195 0.108
microtubule based process GO:0007017 210 0.107
negative regulation of protein metabolic process GO:0051248 391 0.105
nuclear division GO:0000280 128 0.104
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.103
regulation of protein processing GO:0070613 150 0.100
cellular response to abiotic stimulus GO:0071214 117 0.096
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.095
pharynx development GO:0060465 1 0.093
trail activated apoptotic signaling pathway GO:0036462 4 0.092
negative regulation of proteolysis GO:0045861 132 0.091
embryo development GO:0009790 123 0.090
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.090
blastocyst development GO:0001824 3 0.090
negative regulation of cell cycle GO:0045786 193 0.089
regulation of proteasomal protein catabolic process GO:0061136 87 0.089
positive regulation of cell death GO:0010942 263 0.085
positive regulation of protein modification by small protein conjugation or removal GO:1903322 61 0.085
mitotic dna damage checkpoint GO:0044773 28 0.084
vasculature development GO:0001944 181 0.084
regulation of cell motility GO:2000145 299 0.084
negative regulation of catalytic activity GO:0043086 335 0.081
cellular protein catabolic process GO:0044257 261 0.079
protein modification by small protein conjugation GO:0032446 342 0.074
embryonic epithelial tube formation GO:0001838 4 0.073
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.072
modification dependent protein catabolic process GO:0019941 209 0.072
positive regulation of cellular component organization GO:0051130 376 0.071
protein catabolic process GO:0030163 325 0.070
regulation of cell cycle process GO:0010564 266 0.069
cell cycle phase transition GO:0044770 173 0.068
double strand break repair GO:0006302 101 0.068
endothelial cell migration GO:0043542 86 0.068
regulation of angiogenesis GO:0045765 92 0.068
blood vessel development GO:0001568 172 0.067
regulation of cell cycle GO:0051726 393 0.067
regulation of leukocyte differentiation GO:1902105 61 0.066
regulation of cellular protein catabolic process GO:1903362 96 0.064
regulation of anatomical structure morphogenesis GO:0022603 286 0.063
sex differentiation GO:0007548 45 0.062
proteasomal protein catabolic process GO:0010498 176 0.061
epithelial cell migration GO:0010631 119 0.061
regulation of intracellular protein transport GO:0033157 123 0.058
chromosome segregation GO:0007059 114 0.057
response to cytokine GO:0034097 232 0.056
negative regulation of cellular protein metabolic process GO:0032269 353 0.055
response to organic cyclic compound GO:0014070 204 0.055
positive regulation of phosphorylation GO:0042327 394 0.055
regulation of mitotic cell cycle phase transition GO:1901990 118 0.055
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.054
response to organonitrogen compound GO:0010243 156 0.054
leukocyte differentiation GO:0002521 98 0.053
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.052
positive regulation of apoptotic signaling pathway GO:2001235 70 0.051
mitotic sister chromatid segregation GO:0000070 53 0.051
ribonucleotide catabolic process GO:0009261 405 0.051
cell fate determination GO:0001709 3 0.051
extrinsic apoptotic signaling pathway GO:0097191 119 0.050
mitotic nuclear division GO:0007067 119 0.050
i kappab kinase nf kappab signaling GO:0007249 166 0.049
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.048
microtubule cytoskeleton organization GO:0000226 176 0.048
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.048
response to other organism GO:0051707 261 0.048
protein maturation GO:0051604 233 0.048
dna damage checkpoint GO:0000077 68 0.047
regulation of protein localization GO:0032880 296 0.047
negative regulation of transferase activity GO:0051348 124 0.047
positive regulation of protein sumoylation GO:0033235 7 0.047
positive regulation of protein phosphorylation GO:0001934 313 0.046
regulation of myeloid cell differentiation GO:0045637 81 0.046
positive regulation of cellular protein catabolic process GO:1903364 37 0.046
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.046
response to biotic stimulus GO:0009607 276 0.045
organelle assembly GO:0070925 176 0.045
enzyme linked receptor protein signaling pathway GO:0007167 303 0.044
cellular response to radiation GO:0071478 65 0.044
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.044
signal transduction by p53 class mediator GO:0072331 72 0.043
nuclear export GO:0051168 69 0.043
cell type specific apoptotic process GO:0097285 125 0.043
positive regulation of transport GO:0051050 336 0.043
response to radiation GO:0009314 151 0.042
positive regulation of cell proliferation GO:0008284 301 0.042
nucleoside monophosphate metabolic process GO:0009123 191 0.042
regulation of nucleocytoplasmic transport GO:0046822 98 0.042
regulation of cysteine type endopeptidase activity GO:2000116 127 0.041
cell division GO:0051301 168 0.040
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.040
nucleoside phosphate catabolic process GO:1901292 412 0.040
response to mechanical stimulus GO:0009612 51 0.039
ribonucleoside triphosphate catabolic process GO:0009203 391 0.039
tube development GO:0035295 125 0.039
blood vessel morphogenesis GO:0048514 162 0.038
signal transduction in response to dna damage GO:0042770 57 0.038
histone modification GO:0016570 251 0.038
negative regulation of protein modification process GO:0031400 200 0.038
protein export from nucleus GO:0006611 29 0.038
morphogenesis of embryonic epithelium GO:0016331 4 0.038
negative regulation of cytoplasmic transport GO:1903650 46 0.038
tissue migration GO:0090130 119 0.037
cellular response to oxygen containing compound GO:1901701 276 0.037
positive regulation of immune system process GO:0002684 283 0.037
female gamete generation GO:0007292 2 0.037
response to hormone GO:0009725 175 0.037
cellular protein complex assembly GO:0043623 188 0.037
purine ribonucleoside metabolic process GO:0046128 437 0.037
response to tumor necrosis factor GO:0034612 76 0.036
protein homooligomerization GO:0051260 100 0.036
regulation of establishment of protein localization GO:0070201 242 0.036
embryo development ending in birth or egg hatching GO:0009792 34 0.035
nervous system development GO:0007399 293 0.035
microtubule organizing center organization GO:0031023 62 0.035
meiosis i GO:0007127 4 0.035
purine nucleoside monophosphate catabolic process GO:0009128 158 0.034
regulation of protein transport GO:0051223 213 0.033
ubiquitin dependent protein catabolic process GO:0006511 206 0.033
protein localization to organelle GO:0033365 280 0.033
positive regulation of developmental process GO:0051094 314 0.033
positive regulation of cell differentiation GO:0045597 211 0.033
regulation of cell cycle phase transition GO:1901987 126 0.032
cell cycle checkpoint GO:0000075 117 0.032
regulation of peptidase activity GO:0052547 180 0.032
determination of adult lifespan GO:0008340 2 0.032
regulation of dna metabolic process GO:0051052 153 0.032
regulation of locomotion GO:0040012 329 0.032
positive regulation of organelle organization GO:0010638 195 0.031
negative regulation of cell cycle process GO:0010948 121 0.031
negative regulation of programmed cell death GO:0043069 321 0.031
organelle fission GO:0048285 149 0.031
maintenance of protein location in cell GO:0032507 56 0.031
protein oligomerization GO:0051259 173 0.031
dna conformation change GO:0071103 113 0.031
regulation of cytoplasmic transport GO:1903649 149 0.031
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.031
cytoplasmic transport GO:0016482 379 0.031
protein ubiquitination GO:0016567 314 0.031
regulation of cell migration GO:0030334 289 0.030
response to nitrogen compound GO:1901698 184 0.030
dna repair GO:0006281 198 0.030
cellular response to organonitrogen compound GO:0071417 124 0.029
regulation of transferase activity GO:0051338 355 0.029
regulation of lymphocyte activation GO:0051249 103 0.029
regulation of vasculature development GO:1901342 97 0.029
dna damage response signal transduction by p53 class mediator GO:0030330 44 0.029
negative regulation of protein maturation GO:1903318 142 0.028
regulation of cell differentiation GO:0045595 393 0.028
positive regulation of cell cycle process GO:0090068 106 0.027
centrosome organization GO:0051297 58 0.027
lymphocyte activation GO:0046649 133 0.027
purine nucleoside monophosphate metabolic process GO:0009126 186 0.027
digestive tract development GO:0048565 75 0.026
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.026
mitotic cell cycle checkpoint GO:0007093 68 0.026
negative regulation of intracellular signal transduction GO:1902532 183 0.026
regulation of response to external stimulus GO:0032101 222 0.026
negative regulation of transport GO:0051051 176 0.026
positive regulation of apoptotic process GO:0043065 246 0.026
nucleocytoplasmic transport GO:0006913 176 0.025
angiogenesis GO:0001525 147 0.025
circulatory system development GO:0072359 262 0.025
organophosphate catabolic process GO:0046434 430 0.025
intracellular protein transport GO:0006886 270 0.025
defense response to other organism GO:0098542 129 0.025
response to external biotic stimulus GO:0043207 261 0.024
intrinsic apoptotic signaling pathway GO:0097193 127 0.024
epithelium migration GO:0090132 119 0.024
purine containing compound catabolic process GO:0072523 411 0.024
response to acid chemical GO:0001101 66 0.024
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.024
cardiovascular system development GO:0072358 262 0.023
chromatin modification GO:0016568 298 0.023
protein import into nucleus GO:0006606 104 0.023
head development GO:0060322 108 0.022
regulation of cell division GO:0051302 116 0.022
immune system development GO:0002520 195 0.022
ribonucleoside catabolic process GO:0042454 406 0.022
cell cycle g1 s phase transition GO:0044843 80 0.022
signal transduction by phosphorylation GO:0023014 297 0.022
developmental process involved in reproduction GO:0003006 66 0.022
positive regulation of catabolic process GO:0009896 310 0.022
reproductive process GO:0022414 106 0.021
fas signaling pathway GO:0036337 3 0.021
protein targeting GO:0006605 187 0.021
regulation of response to dna damage stimulus GO:2001020 94 0.021
embryonic camera type eye morphogenesis GO:0048596 2 0.021
protein processing GO:0016485 226 0.021
negative regulation of intracellular transport GO:0032387 60 0.021
regulation of protein export from nucleus GO:0046825 15 0.021
modification dependent macromolecule catabolic process GO:0043632 212 0.020
nuclear transport GO:0051169 179 0.020
regulation of cellular component biogenesis GO:0044087 281 0.020
execution phase of apoptosis GO:0097194 32 0.020
regulation of chromatin modification GO:1903308 51 0.020
cellular response to tumor necrosis factor GO:0071356 63 0.020
negative regulation of multicellular organismal process GO:0051241 317 0.020
oogenesis GO:0048477 2 0.020
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.020
regulation of protein catabolic process GO:0042176 155 0.020
innate immune response GO:0045087 178 0.020
response to interferon gamma GO:0034341 39 0.020
protein sumoylation GO:0016925 25 0.020
anatomical structure homeostasis GO:0060249 100 0.020
nucleoside triphosphate catabolic process GO:0009143 394 0.019
dna replication GO:0006260 116 0.019
cellular response to hormone stimulus GO:0032870 125 0.019
telomere maintenance GO:0000723 32 0.019
negative regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043154 46 0.019
negative regulation of phosphate metabolic process GO:0045936 267 0.019
regulation of chromosome organization GO:0033044 103 0.018
ribonucleoside monophosphate catabolic process GO:0009158 158 0.018
positive regulation of nucleotide catabolic process GO:0030813 185 0.018
positive regulation of cellular component movement GO:0051272 181 0.018
centrosome cycle GO:0007098 32 0.018
homeostasis of number of cells GO:0048872 40 0.018
mrna splicing via spliceosome GO:0000398 89 0.018
sister chromatid segregation GO:0000819 54 0.018
positive regulation of chromatin modification GO:1903310 30 0.018
t cell differentiation in thymus GO:0033077 4 0.018
protein polymerization GO:0051258 71 0.018
single organism reproductive process GO:0044702 98 0.017
positive regulation of chromosome organization GO:2001252 41 0.017
regulation of protein targeting GO:1903533 91 0.017
spindle organization GO:0007051 53 0.017
reproductive system development GO:0061458 56 0.017
regulation of mitotic cell cycle GO:0007346 189 0.017
response to oxygen levels GO:0070482 100 0.017
cellular response to peptide GO:1901653 59 0.017
positive regulation of intracellular protein transport GO:0090316 76 0.017
chromatin organization GO:0006325 351 0.017
neural tube formation GO:0001841 3 0.017
spermatid development GO:0007286 4 0.017
leukocyte activation GO:0045321 164 0.017
dna integrity checkpoint GO:0031570 71 0.017
positive regulation of cellular catabolic process GO:0031331 284 0.017
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 15 0.017
cell activation GO:0001775 213 0.016
regulation of epithelial cell migration GO:0010632 93 0.016
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.016
atp metabolic process GO:0046034 176 0.016
ribonucleoside triphosphate metabolic process GO:0009199 412 0.016
nucleoside monophosphate catabolic process GO:0009125 159 0.015
negative regulation of apoptotic signaling pathway GO:2001234 97 0.015
regulation of microtubule cytoskeleton organization GO:0070507 61 0.015
regulation of nervous system development GO:0051960 88 0.015
response to cobalt ion GO:0032025 1 0.015
response to virus GO:0009615 126 0.015
negative regulation of intracellular protein transport GO:0090317 42 0.015
brain development GO:0007420 97 0.015
negative regulation of nucleocytoplasmic transport GO:0046823 37 0.015
cellular macromolecular complex assembly GO:0034622 324 0.015
cellular response to oxidative stress GO:0034599 85 0.015
leukocyte apoptotic process GO:0071887 31 0.015
response to lipid GO:0033993 206 0.015
ribonucleoside monophosphate metabolic process GO:0009161 187 0.015
positive regulation of myeloid leukocyte differentiation GO:0002763 24 0.015
muscle organ development GO:0007517 56 0.014
response to light stimulus GO:0009416 87 0.014
epithelium development GO:0060429 227 0.014
protein targeting to nucleus GO:0044744 104 0.014
myeloid leukocyte differentiation GO:0002573 60 0.014
regulation of chromatin organization GO:1902275 56 0.014
regulation of fas signaling pathway GO:1902044 2 0.014
dna packaging GO:0006323 77 0.014
cell projection morphogenesis GO:0048858 129 0.014
regulation of cytokine production GO:0001817 232 0.014
neural nucleus development GO:0048857 47 0.014
cellular response to endogenous stimulus GO:0071495 336 0.014
central nervous system development GO:0007417 123 0.013
regulation of nucleotide metabolic process GO:0006140 269 0.013
negative regulation of protein processing GO:0010955 142 0.013
regulation of endothelial cell migration GO:0010594 67 0.013
neuron apoptotic process GO:0051402 39 0.013
reproduction GO:0000003 63 0.013
regulation of cell cycle arrest GO:0071156 36 0.013
meiotic chromosome segregation GO:0045132 4 0.013
nitrogen compound transport GO:0071705 191 0.013
purine nucleotide catabolic process GO:0006195 405 0.013
cell development GO:0048468 328 0.013
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.013
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 30 0.013
g1 dna damage checkpoint GO:0044783 18 0.013
positive regulation of nervous system development GO:0051962 54 0.013
regulation of cellular component movement GO:0051270 334 0.013
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 35 0.013
regulation of neural precursor cell proliferation GO:2000177 4 0.013
response to ionizing radiation GO:0010212 65 0.013
purine nucleoside catabolic process GO:0006152 398 0.012
oocyte differentiation GO:0009994 2 0.012
t cell activation GO:0042110 99 0.012
negative regulation of dna replication GO:0008156 29 0.012
negative regulation of cell differentiation GO:0045596 171 0.012
actomyosin structure organization GO:0031032 59 0.012
positive regulation of cell cycle arrest GO:0071158 23 0.012
purine nucleoside triphosphate catabolic process GO:0009146 392 0.012
nuclear import GO:0051170 106 0.012
positive regulation of programmed cell death GO:0043068 249 0.012
response to hypoxia GO:0001666 96 0.012
compound eye development GO:0048749 1 0.012
cell adhesion GO:0007155 325 0.012
gonad development GO:0008406 34 0.012
multicellular organismal aging GO:0010259 3 0.012
single organism nuclear import GO:1902593 104 0.012
stem cell differentiation GO:0048863 93 0.012
negative regulation of cell migration GO:0030336 102 0.012
positive regulation of cell migration GO:0030335 172 0.012
chromosome separation GO:0051304 23 0.012
negative regulation of t cell apoptotic process GO:0070233 4 0.012
nucleoside triphosphate metabolic process GO:0009141 422 0.011
g1 s transition of mitotic cell cycle GO:0000082 78 0.011
nucleotide catabolic process GO:0009166 408 0.011
response to nutrient levels GO:0031667 81 0.011
spindle elongation GO:0051231 4 0.011
immune response GO:0006955 307 0.011
glycosyl compound catabolic process GO:1901658 413 0.011
neurogenesis GO:0022008 169 0.011
oocyte development GO:0048599 1 0.011
generation of precursor metabolites and energy GO:0006091 68 0.011
nucleoside catabolic process GO:0009164 408 0.011
regulation of cell cycle g1 s phase transition GO:1902806 42 0.011
multi organism metabolic process GO:0044033 41 0.011
positive regulation of jak stat cascade GO:0046427 35 0.011
vesicle mediated transport GO:0016192 371 0.011
response to drug GO:0042493 81 0.011
cell projection organization GO:0030030 252 0.011
regulation of cell development GO:0060284 161 0.011
response to extracellular stimulus GO:0009991 85 0.011
positive regulation of histone modification GO:0031058 29 0.011
generation of neurons GO:0048699 152 0.011
engulfment of apoptotic cell GO:0043652 2 0.011
purine ribonucleotide catabolic process GO:0009154 404 0.011
locomotory behavior GO:0007626 1 0.011
response to endoplasmic reticulum stress GO:0034976 49 0.011
embryonic morphogenesis GO:0048598 85 0.011
positive regulation of protein transport GO:0051222 135 0.011
attachment of mitotic spindle microtubules to kinetochore GO:0051315 3 0.011
organ morphogenesis GO:0009887 147 0.011
response to inorganic substance GO:0010035 127 0.010
response to metal ion GO:0010038 84 0.010
negative regulation of response to external stimulus GO:0032102 83 0.010
cell cycle arrest GO:0007050 71 0.010
regulation of dna repair GO:0006282 47 0.010
regulation of protein kinase activity GO:0045859 289 0.010
negative regulation of protein serine threonine kinase activity GO:0071901 57 0.010
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.010
apoptotic mitochondrial changes GO:0008637 57 0.010
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.010
cilium morphogenesis GO:0060271 75 0.010
positive regulation of proteasomal protein catabolic process GO:1901800 35 0.010
regulation of microtubule based process GO:0032886 74 0.010
gland development GO:0048732 48 0.010
mitotic spindle organization GO:0007052 27 0.010
positive regulation of neural precursor cell proliferation GO:2000179 2 0.010

CASP8AP2 disease predictions

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 167 0.140
disease of cellular proliferation DOID:14566 174 0.140
immune system disease DOID:2914 155 0.082
disease of metabolism DOID:0014667 295 0.030
central nervous system disease DOID:331 186 0.012
neurodegenerative disease DOID:1289 102 0.012
nervous system disease DOID:863 431 0.012
hematopoietic system disease DOID:74 100 0.010