Homo sapiens

76 known processes

CD58

CD58 molecule

(Aliases: LFA3,LFA-3,FLJ43722,FLJ23181)

CD58 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein maturation GO:0051604 233 0.205
positive regulation of cell death GO:0010942 263 0.199
cellular amine metabolic process GO:0044106 41 0.180
cellular amino acid metabolic process GO:0006520 116 0.146
negative regulation of protein metabolic process GO:0051248 391 0.119
organonitrogen compound biosynthetic process GO:1901566 200 0.117
regulation of protein maturation GO:1903317 150 0.116
protein processing GO:0016485 226 0.115
regulation of proteolysis GO:0030162 293 0.113
positive regulation of apoptotic process GO:0043065 246 0.112
amine metabolic process GO:0009308 44 0.107
positive regulation of programmed cell death GO:0043068 249 0.098
negative regulation of peptidase activity GO:0010466 91 0.098
negative regulation of protein maturation GO:1903318 142 0.096
regulation of protein localization GO:0032880 296 0.088
regulation of peptidase activity GO:0052547 180 0.088
regulation of transferase activity GO:0051338 355 0.087
positive regulation of transport GO:0051050 336 0.083
negative regulation of protein processing GO:0010955 142 0.083
syncytium formation by plasma membrane fusion GO:0000768 2 0.083
wound healing GO:0042060 115 0.083
regulation of protein processing GO:0070613 150 0.082
regulation of cellular amino acid metabolic process GO:0006521 6 0.080
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.077
negative regulation of catalytic activity GO:0043086 335 0.072
secretion GO:0046903 254 0.070
purine ribonucleoside metabolic process GO:0046128 437 0.070
regulation of cellular ketone metabolic process GO:0010565 50 0.066
nucleoside triphosphate catabolic process GO:0009143 394 0.066
cell division GO:0051301 168 0.066
negative regulation of hydrolase activity GO:0051346 182 0.065
positive regulation of phosphorylation GO:0042327 394 0.065
negative regulation of endopeptidase activity GO:0010951 84 0.063
negative regulation of proteolysis GO:0045861 132 0.062
nucleoside phosphate catabolic process GO:1901292 412 0.062
membrane lipid metabolic process GO:0006643 53 0.061
response to wounding GO:0009611 168 0.060
cell activation GO:0001775 213 0.059
purine containing compound catabolic process GO:0072523 411 0.057
positive regulation of protein phosphorylation GO:0001934 313 0.055
regulation of nucleotide metabolic process GO:0006140 269 0.054
regulation of endopeptidase activity GO:0052548 170 0.054
cell adhesion GO:0007155 325 0.054
multicellular organismal aging GO:0010259 3 0.053
positive regulation of cellular amine metabolic process GO:0033240 7 0.052
response to hormone GO:0009725 175 0.050
regulation of cellular amine metabolic process GO:0033238 11 0.050
positive regulation of cellular component organization GO:0051130 376 0.049
mitotic cell cycle GO:0000278 326 0.047
regulation of secretion GO:0051046 194 0.046
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.046
epithelial cell differentiation GO:0030855 141 0.046
negative regulation of cell death GO:0060548 345 0.046
carbohydrate derivative biosynthetic process GO:1901137 207 0.045
regulation of secretion by cell GO:1903530 177 0.044
negative regulation of cellular protein metabolic process GO:0032269 353 0.044
biological adhesion GO:0022610 331 0.044
purine nucleotide catabolic process GO:0006195 405 0.044
lipid metabolic process GO:0006629 381 0.043
positive regulation of cell proliferation GO:0008284 301 0.042
cell type specific apoptotic process GO:0097285 125 0.041
ribonucleoside triphosphate metabolic process GO:0009199 412 0.041
negative regulation of programmed cell death GO:0043069 321 0.041
epithelium development GO:0060429 227 0.040
single organism cellular localization GO:1902580 332 0.040
regulation of cell cycle GO:0051726 393 0.040
protein oligomerization GO:0051259 173 0.040
purine nucleoside triphosphate catabolic process GO:0009146 392 0.040
immune response GO:0006955 307 0.039
oogenesis GO:0048477 2 0.039
ribonucleoside triphosphate catabolic process GO:0009203 391 0.039
regulation of nucleoside metabolic process GO:0009118 209 0.039
organophosphate catabolic process GO:0046434 430 0.039
single organism cell adhesion GO:0098602 179 0.038
cell morphogenesis GO:0000902 296 0.038
regulation of cytokine production GO:0001817 232 0.037
endomembrane system organization GO:0010256 196 0.037
actin cytoskeleton organization GO:0030036 207 0.037
cellular response to dna damage stimulus GO:0006974 379 0.037
determination of adult lifespan GO:0008340 2 0.036
chemical homeostasis GO:0048878 306 0.036
regulation of reactive oxygen species metabolic process GO:2000377 41 0.036
positive regulation of developmental process GO:0051094 314 0.035
positive regulation of organelle organization GO:0010638 195 0.035
regulation of cell cycle process GO:0010564 266 0.035
innate immune response GO:0045087 178 0.035
single organism membrane organization GO:0044802 268 0.035
positive regulation of catabolic process GO:0009896 310 0.035
protein localization to organelle GO:0033365 280 0.035
glycosyl compound catabolic process GO:1901658 413 0.034
guanosine containing compound metabolic process GO:1901068 244 0.034
purine nucleoside catabolic process GO:0006152 398 0.034
cellular ion homeostasis GO:0006873 168 0.034
negative regulation of apoptotic process GO:0043066 316 0.034
positive regulation of hydrolase activity GO:0051345 331 0.033
organophosphate biosynthetic process GO:0090407 163 0.033
cytokine production GO:0001816 247 0.033
phospholipid metabolic process GO:0006644 99 0.033
regulation of anatomical structure morphogenesis GO:0022603 286 0.033
regulation of cysteine type endopeptidase activity GO:2000116 127 0.032
positive regulation of protein kinase activity GO:0045860 190 0.032
mitotic cell cycle process GO:1903047 286 0.032
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.032
gtp metabolic process GO:0046039 239 0.032
cellular chemical homeostasis GO:0055082 180 0.032
regulation of purine nucleotide metabolic process GO:1900542 264 0.031
response to oxidative stress GO:0006979 121 0.031
regulation of vesicle mediated transport GO:0060627 130 0.031
defense response GO:0006952 315 0.031
regulation of establishment of protein localization GO:0070201 242 0.031
ribonucleotide catabolic process GO:0009261 405 0.031
regulation of nucleotide catabolic process GO:0030811 205 0.031
nucleoside triphosphate metabolic process GO:0009141 422 0.031
cell development GO:0048468 328 0.031
apoptotic signaling pathway GO:0097190 268 0.030
metal ion homeostasis GO:0055065 169 0.030
nucleoside catabolic process GO:0009164 408 0.030
myoblast fusion GO:0007520 1 0.030
ribonucleoside catabolic process GO:0042454 406 0.030
nucleotide catabolic process GO:0009166 408 0.030
sphingolipid metabolic process GO:0006665 38 0.029
purine nucleoside triphosphate metabolic process GO:0009144 412 0.029
cell projection organization GO:0030030 252 0.029
cellular ketone metabolic process GO:0042180 80 0.029
leukocyte migration GO:0050900 107 0.029
positive regulation of nucleotide catabolic process GO:0030813 185 0.029
vasculature development GO:0001944 181 0.028
actin filament based process GO:0030029 224 0.028
regulation of protein transport GO:0051223 213 0.028
regulation of cytokine secretion GO:0050707 57 0.028
regulation of protein secretion GO:0050708 86 0.028
purine ribonucleoside catabolic process GO:0046130 398 0.028
positive regulation of secretion by cell GO:1903532 108 0.028
mitotic cell cycle phase transition GO:0044772 162 0.027
protein catabolic process GO:0030163 325 0.027
carbohydrate metabolic process GO:0005975 207 0.027
response to lipid GO:0033993 206 0.027
secretion by cell GO:0032940 226 0.027
regulation of kinase activity GO:0043549 314 0.026
lipid biosynthetic process GO:0008610 177 0.026
exocytosis GO:0006887 71 0.026
regulation of cellular response to stress GO:0080135 244 0.026
positive regulation of cytokine production GO:0001819 167 0.026
negative regulation of intracellular signal transduction GO:1902532 183 0.026
positive regulation of cellular catabolic process GO:0031331 284 0.025
regulation of mapk cascade GO:0043408 262 0.025
nervous system development GO:0007399 293 0.025
regulation of cell activation GO:0050865 125 0.025
signal transduction by phosphorylation GO:0023014 297 0.025
regulation of purine nucleotide catabolic process GO:0033121 205 0.025
female gamete generation GO:0007292 2 0.025
response to organic cyclic compound GO:0014070 204 0.025
vesicle mediated transport GO:0016192 371 0.024
positive regulation of exocytosis GO:0045921 35 0.024
post embryonic development GO:0009791 2 0.024
mapk cascade GO:0000165 288 0.024
immune system development GO:0002520 195 0.024
mitochondrion organization GO:0007005 156 0.024
regulation of response to wounding GO:1903034 101 0.023
system process GO:0003008 349 0.023
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.023
protein glycosylation GO:0006486 62 0.023
cellular response to endogenous stimulus GO:0071495 336 0.023
metal ion transport GO:0030001 272 0.023
negative regulation of cell cycle GO:0045786 193 0.023
negative regulation of phosphate metabolic process GO:0045936 267 0.023
hematopoietic or lymphoid organ development GO:0048534 186 0.023
protein targeting GO:0006605 187 0.023
regulation of protein kinase activity GO:0045859 289 0.023
positive regulation of nucleoside metabolic process GO:0045979 186 0.023
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.023
transmembrane transport GO:0055085 399 0.022
positive regulation of nucleotide metabolic process GO:0045981 230 0.022
negative regulation of cysteine type endopeptidase activity GO:2000117 48 0.022
regulation of binding GO:0051098 111 0.022
single organism carbohydrate metabolic process GO:0044723 193 0.022
cardiovascular system development GO:0072358 262 0.022
interleukin 8 production GO:0032637 51 0.022
response to biotic stimulus GO:0009607 276 0.022
oxidation reduction process GO:0055114 396 0.021
cellular calcium ion homeostasis GO:0006874 117 0.021
regulation of exocytosis GO:0017157 46 0.021
purine ribonucleotide catabolic process GO:0009154 404 0.021
gtp catabolic process GO:0006184 237 0.021
positive regulation of transferase activity GO:0051347 227 0.021
blood vessel development GO:0001568 172 0.021
divalent inorganic cation transport GO:0072511 158 0.021
regulation of mitotic cell cycle GO:0007346 189 0.021
anatomical structure formation involved in morphogenesis GO:0048646 284 0.021
calcium ion homeostasis GO:0055074 122 0.021
glycosylation GO:0070085 71 0.021
neurogenesis GO:0022008 169 0.020
ribose phosphate biosynthetic process GO:0046390 82 0.020
segmentation GO:0035282 4 0.020
intrinsic apoptotic signaling pathway GO:0097193 127 0.020
response to molecule of bacterial origin GO:0002237 82 0.020
purine nucleotide biosynthetic process GO:0006164 84 0.020
positive regulation of mapk cascade GO:0043410 190 0.019
cellular response to lipid GO:0071396 127 0.019
lymphocyte homeostasis GO:0002260 4 0.019
microtubule cytoskeleton organization GO:0000226 176 0.019
regulation of cellular component biogenesis GO:0044087 281 0.019
camp biosynthetic process GO:0006171 47 0.019
cellular component morphogenesis GO:0032989 314 0.019
intracellular protein transport GO:0006886 270 0.019
regulation of cell morphogenesis GO:0022604 153 0.019
cytokinesis GO:0000910 96 0.019
positive regulation of camp metabolic process GO:0030816 41 0.019
circadian behavior GO:0048512 2 0.019
negative regulation of phosphorus metabolic process GO:0010563 267 0.019
leukocyte activation GO:0045321 164 0.019
glycoprotein biosynthetic process GO:0009101 91 0.019
regulation of response to external stimulus GO:0032101 222 0.019
negative regulation of secretion by cell GO:1903531 52 0.018
small gtpase mediated signal transduction GO:0007264 78 0.018
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.018
cation homeostasis GO:0055080 189 0.018
cell chemotaxis GO:0060326 112 0.018
guanosine containing compound catabolic process GO:1901069 239 0.018
cellular lipid metabolic process GO:0044255 303 0.018
positive regulation of cellular component biogenesis GO:0044089 158 0.018
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.018
circulatory system development GO:0072359 262 0.018
small molecule biosynthetic process GO:0044283 157 0.018
regulation of immune response GO:0050776 201 0.018
ribonucleotide biosynthetic process GO:0009260 81 0.018
regulation of syncytium formation by plasma membrane fusion GO:0060142 2 0.017
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.017
positive regulation of camp biosynthetic process GO:0030819 35 0.017
keratinocyte differentiation GO:0030216 36 0.017
positive regulation of immune system process GO:0002684 283 0.017
negative regulation of secretion GO:0051048 58 0.017
protein homooligomerization GO:0051260 100 0.017
cell growth GO:0016049 160 0.017
cell cycle phase transition GO:0044770 173 0.017
reactive oxygen species metabolic process GO:0072593 75 0.017
chemotaxis GO:0006935 157 0.017
skin development GO:0043588 76 0.017
g1 s transition of mitotic cell cycle GO:0000082 78 0.017
membrane organization GO:0061024 292 0.017
microtubule based process GO:0007017 210 0.017
positive regulation of immune response GO:0050778 159 0.016
response to inorganic substance GO:0010035 127 0.016
regulation of cell motility GO:2000145 299 0.016
response to other organism GO:0051707 261 0.016
blastoderm segmentation GO:0007350 2 0.016
autophagy GO:0006914 88 0.016
response to organonitrogen compound GO:0010243 156 0.016
blood vessel morphogenesis GO:0048514 162 0.016
positive regulation of neutrophil apoptotic process GO:0033031 1 0.016
phospholipid biosynthetic process GO:0008654 44 0.016
positive regulation of endopeptidase activity GO:0010950 84 0.016
calcium ion transport GO:0006816 147 0.016
positive regulation of kinase activity GO:0033674 204 0.016
purine containing compound biosynthetic process GO:0072522 88 0.016
response to cytokine GO:0034097 232 0.016
regulation of cell development GO:0060284 161 0.015
hemopoiesis GO:0030097 180 0.015
cellular metal ion homeostasis GO:0006875 146 0.015
response to bacterium GO:0009617 144 0.015
ion homeostasis GO:0050801 230 0.015
positive regulation of apoptotic signaling pathway GO:2001235 70 0.015
response to tumor necrosis factor GO:0034612 76 0.015
cellular response to glucocorticoid stimulus GO:0071385 4 0.015
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.015
cytokine secretion GO:0050663 64 0.015
cell cycle checkpoint GO:0000075 117 0.015
sequestering of metal ion GO:0051238 24 0.015
macromolecule glycosylation GO:0043413 63 0.015
atp metabolic process GO:0046034 176 0.015
cellular homeostasis GO:0019725 196 0.015
regulation of protein stability GO:0031647 87 0.015
positive regulation of secretion GO:0051047 116 0.015
response to metal ion GO:0010038 84 0.015
nucleotide biosynthetic process GO:0009165 109 0.015
lymphocyte activation GO:0046649 133 0.015
regulation of protein catabolic process GO:0042176 155 0.014
regulation of leukocyte migration GO:0002685 63 0.014
nucleoside phosphate biosynthetic process GO:1901293 109 0.014
response to fungus GO:0009620 4 0.014
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.014
somatic stem cell division GO:0048103 1 0.014
negative regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043154 46 0.014
cellular protein complex assembly GO:0043623 188 0.014
blood coagulation GO:0007596 76 0.014
response to external biotic stimulus GO:0043207 261 0.014
positive regulation of defense response GO:0031349 87 0.014
positive regulation of endocytosis GO:0045807 42 0.014
positive regulation of cellular component movement GO:0051272 181 0.014
hemostasis GO:0007599 76 0.014
cyclic nucleotide metabolic process GO:0009187 82 0.014
cellular divalent inorganic cation homeostasis GO:0072503 128 0.014
reactive oxygen species biosynthetic process GO:1903409 4 0.014
cellular response to oxidative stress GO:0034599 85 0.014
macrophage fusion GO:0034238 1 0.014
neutrophil apoptotic process GO:0001781 2 0.014
divalent metal ion transport GO:0070838 152 0.014
peptidyl serine modification GO:0018209 106 0.013
ceramide metabolic process GO:0006672 25 0.013
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.013
myeloid cell differentiation GO:0030099 117 0.013
response to oxygen containing compound GO:1901700 369 0.013
positive regulation of gtpase activity GO:0043547 166 0.013
coagulation GO:0050817 78 0.013
positive regulation of purine nucleotide biosynthetic process GO:1900373 38 0.013
response to toxic substance GO:0009636 37 0.013
immune effector process GO:0002252 159 0.013
establishment of protein localization to organelle GO:0072594 172 0.013
negative regulation of cell proliferation GO:0008285 228 0.013
chromatin modification GO:0016568 298 0.013
cellular cation homeostasis GO:0030003 163 0.013
regulation of cellular component movement GO:0051270 334 0.013
monocyte aggregation GO:0070487 4 0.013
regulation of map kinase activity GO:0043405 108 0.013
locomotory behavior GO:0007626 1 0.013
response to nutrient levels GO:0031667 81 0.013
regulation of interleukin 8 production GO:0032677 49 0.013
response to starvation GO:0042594 59 0.013
regulation of cytoskeleton organization GO:0051493 177 0.013
neuroblast proliferation GO:0007405 4 0.013
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.013
neuron projection development GO:0031175 106 0.012
spermatid differentiation GO:0048515 4 0.012
phosphatidic acid biosynthetic process GO:0006654 4 0.012
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.012
compound eye development GO:0048749 1 0.012
regulation of protein oligomerization GO:0032459 26 0.012
cyclic purine nucleotide metabolic process GO:0052652 60 0.012
generation of neurons GO:0048699 152 0.012
negative regulation of cell cycle process GO:0010948 121 0.012
stem cell division GO:0017145 2 0.012
regulation of lymphocyte activation GO:0051249 103 0.012
purine ribonucleotide biosynthetic process GO:0009152 79 0.012
regulation of defense response GO:0031347 154 0.012
morphogenesis of embryonic epithelium GO:0016331 4 0.012
neurological system process GO:0050877 163 0.012
negative regulation of protein modification process GO:0031400 200 0.012
ras protein signal transduction GO:0007265 73 0.012
negative regulation of phosphorylation GO:0042326 174 0.012
mononuclear cell proliferation GO:0032943 71 0.012
regulation of intracellular transport GO:0032386 195 0.012
cellular amide metabolic process GO:0043603 69 0.012
establishment of protein localization to membrane GO:0090150 121 0.012
protein import GO:0017038 130 0.012
rho protein signal transduction GO:0007266 26 0.012
embryo development GO:0009790 123 0.012
ribonucleoside monophosphate catabolic process GO:0009158 158 0.012
regulation of protein complex assembly GO:0043254 147 0.012
response to reactive oxygen species GO:0000302 61 0.012
positive regulation of cyclic nucleotide biosynthetic process GO:0030804 38 0.012
cytoplasmic transport GO:0016482 379 0.011
developmental programmed cell death GO:0010623 3 0.011
regulation of camp biosynthetic process GO:0030817 45 0.011
response to calcium ion GO:0051592 46 0.011
lymphocyte mediated immunity GO:0002449 48 0.011
regulation of cell cycle phase transition GO:1901987 126 0.011
cell projection morphogenesis GO:0048858 129 0.011
cell cycle g1 s phase transition GO:0044843 80 0.011
response to abiotic stimulus GO:0009628 336 0.011
cellular response to organic cyclic compound GO:0071407 127 0.011
epidermis development GO:0008544 59 0.011
positive regulation of cell motility GO:2000147 177 0.011
behavior GO:0007610 112 0.011
activation of immune response GO:0002253 114 0.011
negative regulation of transferase activity GO:0051348 124 0.011
motor neuron axon guidance GO:0008045 2 0.011
camp metabolic process GO:0046058 61 0.011
associative learning GO:0008306 1 0.011
alcohol metabolic process GO:0006066 114 0.011
ion transmembrane transport GO:0034220 338 0.011
regulation of innate immune response GO:0045088 97 0.011
glycoprotein metabolic process GO:0009100 110 0.011
regulation of mitotic cell cycle phase transition GO:1901990 118 0.011
neuron development GO:0048666 113 0.011
g protein coupled receptor signaling pathway GO:0007186 207 0.011
regulation of camp metabolic process GO:0030814 52 0.011
negative regulation of mitotic cell cycle GO:0045930 102 0.011
vesicle organization GO:0016050 62 0.011
negative regulation of serine type peptidase activity GO:1902572 2 0.011
regulation of cell adhesion GO:0030155 166 0.011
alditol phosphate metabolic process GO:0052646 3 0.011
cellular response to organonitrogen compound GO:0071417 124 0.011
regulation of apoptotic signaling pathway GO:2001233 175 0.011
engulfment of apoptotic cell GO:0043652 2 0.011
rhythmic behavior GO:0007622 2 0.011
protein localization to membrane GO:0072657 160 0.011
myeloid leukocyte differentiation GO:0002573 60 0.011
sequestering of calcium ion GO:0051208 17 0.011
response to nitrogen compound GO:1901698 184 0.011
protein heterotetramerization GO:0051290 3 0.011
nucleoside monophosphate metabolic process GO:0009123 191 0.011
positive regulation of cell adhesion GO:0045785 84 0.011
interleukin 8 secretion GO:0072606 14 0.011
regulation of growth GO:0040008 165 0.011
central nervous system development GO:0007417 123 0.011
single organismal cell cell adhesion GO:0016337 148 0.011
endosomal transport GO:0016197 129 0.011
regulation of nucleotide biosynthetic process GO:0030808 50 0.011
positive regulation of proteolysis GO:0045862 142 0.010
positive regulation of keratinocyte migration GO:0051549 4 0.010
single organism membrane fusion GO:0044801 37 0.010
posttranscriptional regulation of gene expression GO:0010608 213 0.010
negative regulation of cytokine production GO:0001818 82 0.010
neuroblast division GO:0055057 1 0.010
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.010
response to steroid hormone GO:0048545 80 0.010
protein autophosphorylation GO:0046777 123 0.010
positive regulation of protein complex assembly GO:0031334 86 0.010
ribonucleoside monophosphate metabolic process GO:0009161 187 0.010
enzyme linked receptor protein signaling pathway GO:0007167 303 0.010
apoptotic mitochondrial changes GO:0008637 57 0.010
positive regulation of cell cycle GO:0045787 140 0.010
vesicle docking involved in exocytosis GO:0006904 3 0.010
positive regulation of lymphocyte activation GO:0051251 73 0.010
wnt signaling pathway GO:0016055 156 0.010
regulation of response to dna damage stimulus GO:2001020 94 0.010
organic acid biosynthetic process GO:0016053 97 0.010
protein secretion GO:0009306 98 0.010

CD58 disease predictions

Disease DO term ID Size Probability Func Analog Org
inherited metabolic disorder DOID:655 242 0.048
disease of metabolism DOID:0014667 295 0.048
eye and adnexa disease DOID:1492 150 0.024
eye disease DOID:5614 149 0.024
sensory system disease DOID:0050155 203 0.024
nervous system disease DOID:863 431 0.024
retinal disease DOID:5679 118 0.021
disease of cellular proliferation DOID:14566 174 0.016
cancer DOID:162 167 0.016
disease of mental health DOID:150 70 0.015
organ system cancer DOID:0050686 164 0.015
central nervous system disease DOID:331 186 0.013
immune system disease DOID:2914 155 0.013
musculoskeletal system disease DOID:17 223 0.012
retinal degeneration DOID:8466 89 0.011
connective tissue disease DOID:65 109 0.011
brain disease DOID:936 73 0.010