Homo sapiens

30 known processes

CDKN3

cyclin-dependent kinase inhibitor 3

(Aliases: MGC70625,KAP1,CIP2,FLJ25787,KAP,CDI1)

CDKN3 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of attachment of spindle microtubules to kinetochore GO:0051988 9 0.855
spindle stabilization GO:0043146 4 0.797
microtubule polymerization or depolymerization GO:0031109 37 0.790
spindle assembly GO:0051225 29 0.724
regulation of chromosome segregation GO:0051983 44 0.570
mitotic sister chromatid segregation GO:0000070 53 0.551
meiosis i GO:0007127 4 0.533
modification dependent macromolecule catabolic process GO:0043632 212 0.514
proteasomal protein catabolic process GO:0010498 176 0.488
positive regulation of cell cycle GO:0045787 140 0.485
negative regulation of mitotic metaphase anaphase transition GO:0045841 17 0.402
modification dependent protein catabolic process GO:0019941 209 0.398
ubiquitin dependent protein catabolic process GO:0006511 206 0.379
positive regulation of attachment of spindle microtubules to kinetochore GO:0051987 2 0.370
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 25 0.367
positive regulation of mitotic cell cycle GO:0045931 60 0.363
nuclear division GO:0000280 128 0.356
mitotic nuclear division GO:0007067 119 0.354
regulation of cell cycle GO:0051726 393 0.353
metaphase anaphase transition of cell cycle GO:0044784 21 0.349
cytokinesis GO:0000910 96 0.342
protein catabolic process GO:0030163 325 0.339
negative regulation of mitotic anaphase promoting complex activity GO:0060564 4 0.317
oocyte maturation GO:0001556 1 0.312
cellular protein catabolic process GO:0044257 261 0.311
sister chromatid segregation GO:0000819 54 0.303
regulation of mitotic sister chromatid segregation GO:0033047 27 0.295
positive regulation of cell cycle process GO:0090068 106 0.283
microtubule based process GO:0007017 210 0.275
microtubule cytoskeleton organization GO:0000226 176 0.268
cyclin catabolic process GO:0008054 6 0.265
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.251
cellular macromolecule catabolic process GO:0044265 380 0.242
regulation of mitotic cell cycle GO:0007346 189 0.240
positive regulation of cell division GO:0051781 59 0.240
mitotic sister chromatid separation GO:0051306 18 0.239
organelle fission GO:0048285 149 0.223
protein dephosphorylation GO:0006470 81 0.220
negative regulation of microtubule polymerization or depolymerization GO:0031111 17 0.218
ras protein signal transduction GO:0007265 73 0.212
negative regulation of chromosome organization GO:2001251 48 0.202
cell division GO:0051301 168 0.201
negative regulation of protein metabolic process GO:0051248 391 0.200
organelle assembly GO:0070925 176 0.197
regulation of nuclear division GO:0051783 65 0.187
spindle organization GO:0007051 53 0.182
regulation of mitotic metaphase anaphase transition GO:0030071 26 0.179
mitotic cell cycle process GO:1903047 286 0.173
mitotic cell cycle GO:0000278 326 0.170
regulation of meiotic cell cycle GO:0051445 4 0.170
regulation of mitotic sister chromatid separation GO:0010965 27 0.169
regulation of mitosis GO:0007088 63 0.169
histone serine phosphorylation GO:0035404 4 0.165
cell cycle g2 m phase transition GO:0044839 43 0.160
chromosome segregation GO:0007059 114 0.157
negative regulation of cellular protein metabolic process GO:0032269 353 0.155
negative regulation of protein processing GO:0010955 142 0.154
regulation of spindle organization GO:0090224 10 0.153
protein processing GO:0016485 226 0.150
negative regulation of protein maturation GO:1903318 142 0.146
spindle elongation GO:0051231 4 0.143
mitotic spindle elongation GO:0000022 4 0.138
microtubule based movement GO:0007018 32 0.137
regulation of cell cycle process GO:0010564 266 0.131
regulation of mitotic spindle organization GO:0060236 6 0.127
protein depolymerization GO:0051261 30 0.126
chromosome separation GO:0051304 23 0.126
attachment of spindle microtubules to kinetochore GO:0008608 17 0.125
regulation of metaphase anaphase transition of cell cycle GO:1902099 26 0.123
metaphase anaphase transition of mitotic cell cycle GO:0007091 21 0.122
somatic stem cell division GO:0048103 1 0.122
positive regulation of cellular component organization GO:0051130 376 0.122
negative regulation of phosphorylation GO:0042326 174 0.119
small gtpase mediated signal transduction GO:0007264 78 0.119
positive regulation of organelle organization GO:0010638 195 0.116
embryo development GO:0009790 123 0.114
regulation of triglyceride catabolic process GO:0010896 6 0.113
regulation of microtubule cytoskeleton organization GO:0070507 61 0.112
cellular response to iron ion GO:0071281 1 0.111
cellular protein complex disassembly GO:0043624 36 0.110
regulation of embryonic development GO:0045995 20 0.105
negative regulation of proteolysis GO:0045861 132 0.104
regulation of microtubule polymerization or depolymerization GO:0031110 27 0.103
negative regulation of cellular component organization GO:0051129 235 0.102
negative regulation of organelle organization GO:0010639 126 0.101
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.101
cellular component disassembly GO:0022411 92 0.098
establishment of organelle localization GO:0051656 59 0.096
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.092
regulation of microtubule based process GO:0032886 74 0.086
microtubule organizing center organization GO:0031023 62 0.085
negative regulation of cytoskeleton organization GO:0051494 45 0.083
regulation of proteolysis GO:0030162 293 0.081
positive regulation of catabolic process GO:0009896 310 0.079
regulation of cell division GO:0051302 116 0.079
regulation of transferase activity GO:0051338 355 0.078
dephosphorylation GO:0016311 209 0.078
positive regulation of meiotic cell cycle GO:0051446 2 0.077
post embryonic development GO:0009791 2 0.077
positive regulation of cell proliferation GO:0008284 301 0.076
regeneration GO:0031099 4 0.075
single organism cellular localization GO:1902580 332 0.074
spindle midzone assembly GO:0051255 4 0.074
negative regulation of protein modification process GO:0031400 200 0.073
lymphocyte homeostasis GO:0002260 4 0.071
mitotic cell cycle phase transition GO:0044772 162 0.071
peptidyl serine modification GO:0018209 106 0.069
regulation of protein catabolic process GO:0042176 155 0.067
regulation of protein localization GO:0032880 296 0.065
positive regulation of cell differentiation GO:0045597 211 0.064
positive regulation of chromosome segregation GO:0051984 9 0.063
cellular macromolecular complex assembly GO:0034622 324 0.062
organelle localization GO:0051640 84 0.060
negative regulation of cellular catabolic process GO:0031330 83 0.059
male meiosis GO:0007140 1 0.058
neuroblast division GO:0055057 1 0.058
spindle assembly involved in mitosis GO:0090307 12 0.058
microtubule depolymerization GO:0007019 18 0.057
cellular chemical homeostasis GO:0055082 180 0.056
regulation of kinase activity GO:0043549 314 0.055
positive regulation of protein phosphorylation GO:0001934 313 0.055
protein maturation GO:0051604 233 0.055
regulation of mitotic cell cycle phase transition GO:1901990 118 0.054
negative regulation of phosphorus metabolic process GO:0010563 267 0.054
negative regulation of protein dephosphorylation GO:0035308 3 0.054
negative regulation of ubiquitin protein ligase activity involved in mitotic cell cycle GO:0051436 4 0.052
cellular protein complex assembly GO:0043623 188 0.052
negative regulation of catalytic activity GO:0043086 335 0.052
regulation of cell differentiation GO:0045595 393 0.051
negative regulation of catabolic process GO:0009895 104 0.051
positive regulation of nuclear division GO:0051785 27 0.051
positive regulation of phosphorylation GO:0042327 394 0.050
negative regulation of mitotic cell cycle GO:0045930 102 0.049
regulation of cytoskeleton organization GO:0051493 177 0.048
cytoskeleton dependent cytokinesis GO:0061640 22 0.048
mitotic cytokinesis GO:0000281 19 0.047
organophosphate biosynthetic process GO:0090407 163 0.047
mitotic spindle organization GO:0007052 27 0.046
maintenance of location GO:0051235 112 0.044
positive regulation of mitosis GO:0045840 25 0.044
regulation of chromosome organization GO:0033044 103 0.044
regulation of sister chromatid segregation GO:0033045 27 0.043
neurogenesis GO:0022008 169 0.043
protein complex disassembly GO:0043241 52 0.043
cell morphogenesis GO:0000902 296 0.043
oogenesis GO:0048477 2 0.042
maintenance of location in cell GO:0051651 62 0.042
g2 m transition of mitotic cell cycle GO:0000086 41 0.041
regulation of protein kinase activity GO:0045859 289 0.039
regulation of protein processing GO:0070613 150 0.038
tissue regeneration GO:0042246 3 0.038
female gamete generation GO:0007292 2 0.038
regulation of cellular protein catabolic process GO:1903362 96 0.037
epithelial cell differentiation GO:0030855 141 0.037
chemical homeostasis GO:0048878 306 0.036
positive regulation of programmed cell death GO:0043068 249 0.036
regulation of protein maturation GO:1903317 150 0.036
regulation of dna replication GO:0006275 68 0.035
regulation of peptidase activity GO:0052547 180 0.035
asymmetric neuroblast division GO:0055059 1 0.035
mitotic spindle stabilization GO:0043148 2 0.034
positive regulation of mitotic cell cycle phase transition GO:1901992 19 0.034
negative regulation of mitotic sister chromatid separation GO:2000816 17 0.034
positive regulation of chromosome organization GO:2001252 41 0.034
cellular response to abiotic stimulus GO:0071214 117 0.032
negative regulation of cellular protein catabolic process GO:1903363 38 0.032
stem cell differentiation GO:0048863 93 0.032
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.031
positive regulation of proteolysis GO:0045862 142 0.031
regulation of stress activated mapk cascade GO:0032872 84 0.031
positive regulation of cytoskeleton organization GO:0051495 83 0.031
mitotic spindle midzone assembly GO:0051256 4 0.031
negative regulation of phosphate metabolic process GO:0045936 267 0.030
regulation of dephosphorylation GO:0035303 96 0.030
negative regulation of cell cycle GO:0045786 193 0.030
regulation of binding GO:0051098 111 0.029
dna packaging GO:0006323 77 0.029
regulation of meiosis GO:0040020 3 0.029
nucleotide biosynthetic process GO:0009165 109 0.028
regulation of small gtpase mediated signal transduction GO:0051056 156 0.027
stem cell division GO:0017145 2 0.027
cell development GO:0048468 328 0.027
maintenance of protein location GO:0045185 57 0.027
determination of adult lifespan GO:0008340 2 0.027
secretion GO:0046903 254 0.027
regulation of mapk cascade GO:0043408 262 0.026
ribonucleoside monophosphate catabolic process GO:0009158 158 0.026
cell fate determination GO:0001709 3 0.026
exit from mitosis GO:0010458 10 0.026
secretion by cell GO:0032940 226 0.026
cell cycle phase transition GO:0044770 173 0.026
oocyte differentiation GO:0009994 2 0.026
cellular response to oxygen containing compound GO:1901701 276 0.025
neural crest cell migration GO:0001755 2 0.025
response to lipid GO:0033993 206 0.025
negative regulation of cell cycle phase transition GO:1901988 89 0.025
regulation of cell cycle phase transition GO:1901987 126 0.025
negative regulation of peptidase activity GO:0010466 91 0.025
negative regulation of sister chromatid segregation GO:0033046 17 0.024
regulation of protein serine threonine kinase activity GO:0071900 179 0.024
positive regulation of dna metabolic process GO:0051054 73 0.024
positive regulation of metaphase anaphase transition of cell cycle GO:1902101 6 0.024
peptidyl serine phosphorylation GO:0018105 101 0.024
mrna processing GO:0006397 133 0.024
protein polymerization GO:0051258 71 0.023
positive regulation of protein kinase activity GO:0045860 190 0.023
positive regulation of cardiac muscle cell proliferation GO:0060045 2 0.023
negative regulation of chromosome segregation GO:0051985 18 0.023
regulation of protein complex assembly GO:0043254 147 0.023
protein targeting GO:0006605 187 0.023
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.022
regulation of exit from mitosis GO:0007096 6 0.022
nervous system development GO:0007399 293 0.022
cellular lipid metabolic process GO:0044255 303 0.022
stem cell development GO:0048864 69 0.022
regulation of proteasomal protein catabolic process GO:0061136 87 0.022
neuronal stem cell division GO:0036445 1 0.022
meiotic chromosome segregation GO:0045132 4 0.021
negative regulation of endopeptidase activity GO:0010951 84 0.021
cell cycle checkpoint GO:0000075 117 0.021
dna repair GO:0006281 198 0.021
cell cycle g1 s phase transition GO:0044843 80 0.020
stress activated protein kinase signaling cascade GO:0031098 94 0.020
cellular ketone metabolic process GO:0042180 80 0.020
dna replication GO:0006260 116 0.020
biological adhesion GO:0022610 331 0.020
regulation of ras protein signal transduction GO:0046578 155 0.020
macromolecular complex disassembly GO:0032984 60 0.020
positive regulation of developmental process GO:0051094 314 0.020
regulation of dna metabolic process GO:0051052 153 0.020
reproduction GO:0000003 63 0.020
carbohydrate derivative biosynthetic process GO:1901137 207 0.020
microtubule anchoring GO:0034453 24 0.020
positive regulation of organ growth GO:0046622 2 0.020
nucleoside phosphate biosynthetic process GO:1901293 109 0.020
protein oligomerization GO:0051259 173 0.019
regulation of cellular amine metabolic process GO:0033238 11 0.019
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 36 0.019
regulation of protein dephosphorylation GO:0035304 18 0.019
establishment of chromosome localization GO:0051303 20 0.019
cellular component morphogenesis GO:0032989 314 0.018
negative regulation of metaphase anaphase transition of cell cycle GO:1902100 17 0.018
microtubule cytoskeleton organization involved in mitosis GO:1902850 15 0.018
ribonucleotide catabolic process GO:0009261 405 0.018
cell cell signaling GO:0007267 155 0.018
positive regulation of kinase activity GO:0033674 204 0.018
protein autophosphorylation GO:0046777 123 0.017
cellular homeostasis GO:0019725 196 0.017
growth GO:0040007 202 0.017
response to organic cyclic compound GO:0014070 204 0.017
positive regulation of cytokinesis GO:0032467 29 0.017
protein import into nucleus GO:0006606 104 0.017
negative regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0017055 2 0.017
mitotic spindle checkpoint GO:0071174 18 0.017
neuromuscular junction development GO:0007528 3 0.017
organophosphate catabolic process GO:0046434 430 0.017
positive regulation of proteasomal protein catabolic process GO:1901800 35 0.016
maintenance of protein location in cell GO:0032507 56 0.016
multi organism reproductive process GO:0044703 54 0.016
negative regulation of proteasomal protein catabolic process GO:1901799 32 0.016
negative regulation of protein catabolic process GO:0042177 59 0.016
signal transduction by phosphorylation GO:0023014 297 0.016
negative regulation of proteolysis involved in cellular protein catabolic process GO:1903051 35 0.016
protein localization to organelle GO:0033365 280 0.016
response to abiotic stimulus GO:0009628 336 0.016
negative regulation of cell division GO:0051782 31 0.015
cell part morphogenesis GO:0032990 137 0.015
cardiovascular system development GO:0072358 262 0.015
generation of neurons GO:0048699 152 0.015
cell adhesion GO:0007155 325 0.015
cellular response to lipid GO:0071396 127 0.015
cell fate commitment GO:0045165 27 0.015
response to light stimulus GO:0009416 87 0.015
regulation of ubiquitin protein transferase activity GO:0051438 28 0.015
regulation of endopeptidase activity GO:0052548 170 0.015
regulation of cardiac muscle tissue growth GO:0055021 4 0.014
tube development GO:0035295 125 0.014
negative regulation of dephosphorylation GO:0035305 63 0.014
regulation of nucleotide metabolic process GO:0006140 269 0.014
meiotic nuclear division GO:0007126 10 0.014
negative regulation of protein modification by small protein conjugation or removal GO:1903321 41 0.014
histone modification GO:0016570 251 0.014
regulation of response to dna damage stimulus GO:2001020 94 0.014
centrosome organization GO:0051297 58 0.014
negative regulation of intracellular signal transduction GO:1902532 183 0.014
nucleoside triphosphate metabolic process GO:0009141 422 0.014
positive regulation of mitotic sister chromatid separation GO:1901970 6 0.014
cellular response to dna damage stimulus GO:0006974 379 0.014
multicellular organismal aging GO:0010259 3 0.014
positive regulation of cell death GO:0010942 263 0.013
spermatogenesis GO:0007283 22 0.013
oocyte development GO:0048599 1 0.013
mitotic cell cycle checkpoint GO:0007093 68 0.013
cellular amino acid metabolic process GO:0006520 116 0.013
regulation of cell diameter GO:0060305 1 0.013
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.013
regulation of protein ubiquitination GO:0031396 95 0.013
negative regulation of protein phosphorylation GO:0001933 140 0.013
centrosome cycle GO:0007098 32 0.013
mrna metabolic process GO:0016071 175 0.013
positive regulation of exit from mitosis GO:0031536 2 0.013
regulation of cellular response to stress GO:0080135 244 0.013
cofactor metabolic process GO:0051186 87 0.012
regulation of epithelial cell proliferation GO:0050678 113 0.012
response to mechanical stimulus GO:0009612 51 0.012
positive regulation of immune system process GO:0002684 283 0.012
establishment of protein localization to organelle GO:0072594 172 0.012
neuroblast proliferation GO:0007405 4 0.012
negative regulation of hydrolase activity GO:0051346 182 0.012
asymmetric stem cell division GO:0098722 1 0.012
neuron differentiation GO:0030182 138 0.012
negative regulation of microtubule depolymerization GO:0007026 12 0.012
negative regulation of cell cycle process GO:0010948 121 0.012
cilium organization GO:0044782 68 0.012
negative regulation of methylation dependent chromatin silencing GO:0090310 2 0.012
cell growth GO:0016049 160 0.012
purine nucleoside monophosphate catabolic process GO:0009128 158 0.012
endocytosis GO:0006897 159 0.012
endomembrane system organization GO:0010256 196 0.012
response to oxygen containing compound GO:1901700 369 0.012
response to wounding GO:0009611 168 0.011
positive regulation of nucleotide metabolic process GO:0045981 230 0.011
reactive oxygen species metabolic process GO:0072593 75 0.011
mitotic metaphase plate congression GO:0007080 14 0.011
regulation of mrna metabolic process GO:1903311 53 0.011
striated muscle tissue development GO:0014706 59 0.011
mapk cascade GO:0000165 288 0.011
single organism reproductive process GO:0044702 98 0.011
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.011
response to hormone GO:0009725 175 0.011
protein k48 linked ubiquitination GO:0070936 38 0.011
negative regulation of cell death GO:0060548 345 0.011
chromosome condensation GO:0030261 15 0.011
protein localization to chromosome centromeric region GO:0071459 12 0.011
spermatid differentiation GO:0048515 4 0.011
negative regulation of protein complex disassembly GO:0043242 20 0.011
single organism membrane organization GO:0044802 268 0.011
regulation of cardiac muscle cell proliferation GO:0060043 4 0.011
meiotic cell cycle GO:0051321 13 0.011
dna dependent dna replication GO:0006261 44 0.011
meiotic cell cycle process GO:1903046 8 0.010
negative regulation of protein depolymerization GO:1901880 17 0.010
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.010
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 35 0.010
positive regulation of hematopoietic progenitor cell differentiation GO:1901534 5 0.010
regulation of hormone secretion GO:0046883 57 0.010
coenzyme metabolic process GO:0006732 65 0.010
nucleoside phosphate catabolic process GO:1901292 412 0.010
regulation of protein complex disassembly GO:0043244 28 0.010
negative regulation of mitosis GO:0045839 24 0.010
regulation of homeostatic process GO:0032844 121 0.010
positive regulation of apoptotic process GO:0043065 246 0.010
positive regulation of cellular catabolic process GO:0031331 284 0.010
sister chromatid biorientation GO:0031134 2 0.010
ribosome assembly GO:0042255 9 0.010

CDKN3 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.032
inherited metabolic disorder DOID:655 242 0.032