Homo sapiens

186 known processes

CHD8

chromodomain helicase DNA binding protein 8

(Aliases: DKFZp686N17164,HELSNF1,KIAA1564)

CHD8 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
chromatin organization GO:0006325 351 0.997
chromatin modification GO:0016568 298 0.995
histone lysine methylation GO:0034968 50 0.988
cranial nerve development GO:0021545 4 0.978
Human
histone modification GO:0016570 251 0.974
covalent chromatin modification GO:0016569 254 0.970
segmentation GO:0035282 4 0.970
Fly
macromolecule methylation GO:0043414 97 0.954
dna conformation change GO:0071103 113 0.945
methylation GO:0032259 106 0.921
nerve development GO:0021675 4 0.919
Human
histone methylation GO:0016571 60 0.889
protein alkylation GO:0008213 74 0.884
growth hormone secretion GO:0030252 4 0.847
Human
blastoderm segmentation GO:0007350 2 0.819
Fly
ribonucleoside monophosphate catabolic process GO:0009158 158 0.736
regulation of hormone levels GO:0010817 125 0.726
Human
inner ear morphogenesis GO:0042472 4 0.722
Human
purine nucleoside triphosphate catabolic process GO:0009146 392 0.719
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.695
nucleoside monophosphate catabolic process GO:0009125 159 0.637
nucleoside phosphate catabolic process GO:1901292 412 0.634
short term memory GO:0007614 1 0.625
Fly
cellular amino acid metabolic process GO:0006520 116 0.623
regulation of cellular amine metabolic process GO:0033238 11 0.619
purine ribonucleotide catabolic process GO:0009154 404 0.618
semicircular canal morphogenesis GO:0048752 1 0.603
nucleoside catabolic process GO:0009164 408 0.603
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.594
nose development GO:0043584 2 0.565
Human
peptide secretion GO:0002790 51 0.554
Human
amine metabolic process GO:0009308 44 0.552
dna geometric change GO:0032392 32 0.545
hindlimb morphogenesis GO:0035137 2 0.544
cardiovascular system development GO:0072358 262 0.534
Human
cellular component morphogenesis GO:0032989 314 0.524
Fly
atp dependent chromatin remodeling GO:0043044 25 0.520
protein acetylation GO:0006473 116 0.501
memory GO:0007613 3 0.485
Fly
canonical wnt signaling pathway GO:0060070 116 0.470
purine containing compound catabolic process GO:0072523 411 0.462
protein methylation GO:0006479 74 0.460
regulation of growth hormone secretion GO:0060123 3 0.453
Human
locomotory behavior GO:0007626 1 0.446
regionalization GO:0003002 29 0.441
Fly
peptidyl lysine acetylation GO:0018394 101 0.429
cellular ketone metabolic process GO:0042180 80 0.426
cellular response to dna damage stimulus GO:0006974 379 0.421
cell activation GO:0001775 213 0.414
Human
embryonic hindlimb morphogenesis GO:0035116 2 0.405
adult locomotory behavior GO:0008344 1 0.403
ribonucleoside monophosphate metabolic process GO:0009161 187 0.399
purine nucleotide catabolic process GO:0006195 405 0.384
glycosyl compound catabolic process GO:1901658 413 0.382
nucleotide catabolic process GO:0009166 408 0.378
regulation of secretion by cell GO:1903530 177 0.363
Human
histone h3 k4 methylation GO:0051568 27 0.343
adult heart development GO:0007512 6 0.341
ribonucleotide catabolic process GO:0009261 405 0.329
purine nucleoside triphosphate metabolic process GO:0009144 412 0.324
hormone transport GO:0009914 68 0.320
Human
blood vessel morphogenesis GO:0048514 162 0.314
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.314
chromatin remodeling GO:0006338 55 0.313
purine nucleoside catabolic process GO:0006152 398 0.313
regulation of transcription from rna polymerase iii promoter GO:0006359 13 0.304
wnt signaling pathway GO:0016055 156 0.304
internal protein amino acid acetylation GO:0006475 101 0.303
ribonucleoside triphosphate metabolic process GO:0009199 412 0.300
nucleosome organization GO:0034728 66 0.300
regulation of peptide hormone secretion GO:0090276 41 0.284
Human
humoral immune response GO:0006959 49 0.276
Fly
peptide transport GO:0015833 74 0.275
Human
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.275
signal release GO:0023061 70 0.272
Human
protein dna complex subunit organization GO:0071824 80 0.265
regulation of chromatin organization GO:1902275 56 0.264
peptide hormone secretion GO:0030072 50 0.264
Human
regulation of peptide transport GO:0090087 62 0.261
Human
positive regulation of transcription from rna polymerase ii promoter in response to stress GO:0036003 9 0.261
Human
cellular response to oxidative stress GO:0034599 85 0.258
Human
cell cell signaling GO:0007267 155 0.255
Human
regulation of cellular ketone metabolic process GO:0010565 50 0.254
regulation of cellular amino acid metabolic process GO:0006521 6 0.253
mrna metabolic process GO:0016071 175 0.244
positive regulation of organ growth GO:0046622 2 0.234
Fly
purine nucleoside monophosphate catabolic process GO:0009128 158 0.227
transcription from rna polymerase iii promoter GO:0006383 19 0.226
taxis GO:0042330 157 0.226
Fly
nucleoside monophosphate metabolic process GO:0009123 191 0.223
regulation of gene expression epigenetic GO:0040029 73 0.222
nucleoside triphosphate catabolic process GO:0009143 394 0.221
regulation of cell differentiation GO:0045595 393 0.219
leukocyte differentiation GO:0002521 98 0.219
Human
purine ribonucleoside catabolic process GO:0046130 398 0.219
skeletal system development GO:0001501 79 0.214
Human
semicircular canal development GO:0060872 1 0.213
histone acetylation GO:0016573 93 0.212
immune system development GO:0002520 195 0.212
Human
circulatory system development GO:0072359 262 0.212
Human
leukocyte activation GO:0045321 164 0.208
Human
nucleoside triphosphate metabolic process GO:0009141 422 0.206
regulation of histone acetylation GO:0035065 19 0.204
amide transport GO:0042886 76 0.203
Human
internal peptidyl lysine acetylation GO:0018393 97 0.196
cell morphogenesis involved in differentiation GO:0000904 144 0.191
Fly
peptidyl lysine methylation GO:0018022 37 0.187
neuron projection morphogenesis GO:0048812 50 0.186
Fly
response to other organism GO:0051707 261 0.185
Fly
positive regulation of dna templated transcription elongation GO:0032786 18 0.183
cell development GO:0048468 328 0.181
Fly
blood vessel development GO:0001568 172 0.181
post embryonic development GO:0009791 2 0.177
Fly
organ morphogenesis GO:0009887 147 0.176
Human Fly
histone h4 k8 acetylation GO:0043982 15 0.174
female genitalia development GO:0030540 2 0.173
organ growth GO:0035265 12 0.172
Fly
secretion GO:0046903 254 0.166
Human
cytoplasmic transport GO:0016482 379 0.164
transcription elongation from rna polymerase ii promoter GO:0006368 18 0.156
peptidyl lysine modification GO:0018205 144 0.155
dna duplex unwinding GO:0032508 30 0.150
olfactory lobe development GO:0021988 5 0.144
cell projection organization GO:0030030 252 0.142
Fly
vasculature development GO:0001944 181 0.142
nervous system development GO:0007399 293 0.141
Human Fly
response to external biotic stimulus GO:0043207 261 0.141
Fly
cellular amine metabolic process GO:0044106 41 0.140
ribonucleoside triphosphate catabolic process GO:0009203 391 0.134
pattern specification process GO:0007389 43 0.133
Fly
sex differentiation GO:0007548 45 0.133
Human
positive regulation of growth GO:0045927 58 0.131
Fly
transdifferentiation GO:0060290 2 0.130
determination of adult lifespan GO:0008340 2 0.130
Fly
negative regulation of cell cycle GO:0045786 193 0.130
ear morphogenesis GO:0042471 7 0.129
Human
chordate embryonic development GO:0043009 34 0.128
Human Mouse
heart development GO:0007507 95 0.126
Human
neurogenesis GO:0022008 169 0.126
Fly
sensory perception of sound GO:0007605 37 0.124
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 17 0.121
Human
regulation of peptide secretion GO:0002791 42 0.118
Human
regulation of chromosome organization GO:0033044 103 0.116
tube morphogenesis GO:0035239 95 0.115
neuron projection development GO:0031175 106 0.110
Fly
dna packaging GO:0006323 77 0.109
reproductive system development GO:0061458 56 0.109
Human
olfactory bulb development GO:0021772 5 0.107
aging GO:0007568 66 0.106
Fly
cell projection morphogenesis GO:0048858 129 0.105
Fly
protein acylation GO:0043543 138 0.102
regulation of cell cycle process GO:0010564 266 0.096
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 10 0.095
system process GO:0003008 349 0.089
Human Fly
cell part morphogenesis GO:0032990 137 0.087
Fly
central nervous system development GO:0007417 123 0.087
Human
regulation of cell cycle phase transition GO:1901987 126 0.083
anterior posterior axis specification GO:0009948 2 0.081
mitotic cell cycle GO:0000278 326 0.079
negative regulation of protein metabolic process GO:0051248 391 0.078
negative regulation of cell cycle process GO:0010948 121 0.075
dna templated transcription elongation GO:0006354 25 0.074
response to lipid GO:0033993 206 0.074
negative regulation of gene expression epigenetic GO:0045814 19 0.074
cell morphogenesis GO:0000902 296 0.073
Fly
epithelium development GO:0060429 227 0.073
Fly
protein processing GO:0016485 226 0.072
regulation of growth GO:0040008 165 0.072
Fly
negative regulation of cellular protein metabolic process GO:0032269 353 0.071
myeloid cell differentiation GO:0030099 117 0.070
embryonic appendage morphogenesis GO:0035113 9 0.069
regulation of cell cycle GO:0051726 393 0.068
regulation of response to dna damage stimulus GO:2001020 94 0.066
mitotic cell cycle process GO:1903047 286 0.065
response to organic cyclic compound GO:0014070 204 0.062
oocyte differentiation GO:0009994 2 0.061
regulation of chromatin modification GO:1903308 51 0.060
lymphocyte activation GO:0046649 133 0.060
Human
protein ubiquitination GO:0016567 314 0.060
neurological system process GO:0050877 163 0.060
Human Fly
regulation of transcription elongation from rna polymerase ii promoter GO:0034243 13 0.060
cell cycle phase transition GO:0044770 173 0.059
embryo development GO:0009790 123 0.059
Human Mouse Fly
tube development GO:0035295 125 0.056
generation of neurons GO:0048699 152 0.056
Fly
t cell activation GO:0042110 99 0.055
Human
histone h4 k5 acetylation GO:0043981 15 0.055
organophosphate catabolic process GO:0046434 430 0.054
regulation of dna templated transcription elongation GO:0032784 23 0.053
female gamete generation GO:0007292 2 0.053
Fly
hemopoiesis GO:0030097 180 0.053
Human
cell fate determination GO:0001709 3 0.052
artery morphogenesis GO:0048844 7 0.052
developmental process involved in reproduction GO:0003006 66 0.052
Human Fly
gene silencing GO:0016458 49 0.051
cell morphogenesis involved in neuron differentiation GO:0048667 44 0.050
Fly
compound eye development GO:0048749 1 0.050
primary neural tube formation GO:0014020 3 0.050
t cell differentiation GO:0030217 29 0.049
Human
peptidyl lysine dimethylation GO:0018027 3 0.049
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.049
positive regulation of transcription from rna polymerase ii promoter in response to oxidative stress GO:0036091 3 0.048
Human
rna splicing GO:0008380 131 0.048
small gtpase mediated signal transduction GO:0007264 78 0.046
inner ear development GO:0048839 8 0.046
Human
cellular protein catabolic process GO:0044257 261 0.046
purine ribonucleoside metabolic process GO:0046128 437 0.045
morphogenesis of embryonic epithelium GO:0016331 4 0.044
circulatory system process GO:0003013 113 0.043
nucleosome positioning GO:0016584 3 0.043
cell cycle checkpoint GO:0000075 117 0.042
blood circulation GO:0008015 113 0.042
positive regulation of developmental process GO:0051094 314 0.042
Fly
face development GO:0060324 12 0.041
Human
demethylation GO:0070988 37 0.041
protein catabolic process GO:0030163 325 0.040
brain development GO:0007420 97 0.040
cellular macromolecular complex assembly GO:0034622 324 0.040
histone demethylation GO:0016577 15 0.040
positive regulation of cell proliferation GO:0008284 301 0.039
oocyte development GO:0048599 1 0.039
regulation of mitotic cell cycle GO:0007346 189 0.039
nucleocytoplasmic transport GO:0006913 176 0.039
ras protein signal transduction GO:0007265 73 0.038
rna processing GO:0006396 255 0.038
positive regulation of histone modification GO:0031058 29 0.037
dna modification GO:0006304 27 0.037
ribonucleoprotein complex subunit organization GO:0071826 81 0.037
negative regulation of posttranscriptional gene silencing GO:0060149 3 0.037
multicellular organismal aging GO:0010259 3 0.036
Fly
response to wounding GO:0009611 168 0.036
oogenesis GO:0048477 2 0.036
Fly
regulation of histone modification GO:0031056 47 0.036
mrna splicing via spliceosome GO:0000398 89 0.036
positive regulation of cellular component organization GO:0051130 376 0.036
tripartite regional subdivision GO:0007351 2 0.036
anterior posterior axis specification embryo GO:0008595 2 0.036
anatomical structure homeostasis GO:0060249 100 0.036
appendage morphogenesis GO:0035107 16 0.036
Fly
regulation of mitotic cell cycle phase transition GO:1901990 118 0.036
chromatin assembly or disassembly GO:0006333 78 0.035
reproductive structure development GO:0048608 55 0.035
Human
somitogenesis GO:0001756 2 0.035
developmental growth GO:0048589 48 0.035
Fly
axonogenesis GO:0007409 31 0.034
Fly
histone h3 k4 trimethylation GO:0080182 7 0.034
limb morphogenesis GO:0035108 16 0.034
response to estrogen GO:0043627 47 0.033
genetic imprinting GO:0071514 1 0.033
nitrogen compound transport GO:0071705 191 0.033
Human
mrna processing GO:0006397 133 0.033
chromatin assembly GO:0031497 61 0.033
sensory perception of mechanical stimulus GO:0050954 37 0.033
single organism reproductive process GO:0044702 98 0.032
Human Fly
vesicle mediated transport GO:0016192 371 0.032
artery development GO:0060840 7 0.032
ribonucleoprotein complex biogenesis GO:0022613 116 0.031
embryonic limb morphogenesis GO:0030326 9 0.031
response to growth factor GO:0070848 205 0.031
intracellular protein transport GO:0006886 270 0.031
protein modification by small protein conjugation GO:0032446 342 0.031
neural tube formation GO:0001841 3 0.031
protein targeting GO:0006605 187 0.030
protein maturation GO:0051604 233 0.030
response to hormone GO:0009725 175 0.030
sensory organ development GO:0007423 52 0.030
Human
protein localization to organelle GO:0033365 280 0.029
respiratory system development GO:0060541 22 0.029
Human
lymphocyte differentiation GO:0030098 35 0.029
Human
positive regulation of cellular amine metabolic process GO:0033240 7 0.029
regulation of response to external stimulus GO:0032101 222 0.028
negative regulation of phosphorus metabolic process GO:0010563 267 0.028
embryonic epithelial tube formation GO:0001838 4 0.028
developmental maturation GO:0021700 28 0.028
Fly
histone h3 k27 demethylation GO:0071557 3 0.028
phosphorylation of rna polymerase ii c terminal domain GO:0070816 3 0.027
anatomical structure formation involved in morphogenesis GO:0048646 284 0.027
negative regulation of programmed cell death GO:0043069 321 0.027
Mouse
regulation of protein processing GO:0070613 150 0.027
negative regulation of transport GO:0051051 176 0.027
neuron differentiation GO:0030182 138 0.027
Fly
positive regulation of gtpase activity GO:0043547 166 0.027
dna methylation or demethylation GO:0044728 19 0.026
regulation of histone h3 k4 methylation GO:0051569 10 0.026
negative regulation of mitotic cell cycle GO:0045930 102 0.026
cognition GO:0050890 43 0.026
Human Fly
regulation of defense response GO:0031347 154 0.026
response to steroid hormone GO:0048545 80 0.025
embryonic camera type eye morphogenesis GO:0048596 2 0.025
positive regulation of programmed cell death GO:0043068 249 0.025
reproductive process GO:0022414 106 0.025
Human Fly
ubiquitin dependent protein catabolic process GO:0006511 206 0.025
positive regulation of hydrolase activity GO:0051345 331 0.025
negative regulation of protein modification process GO:0031400 200 0.025
adult behavior GO:0030534 18 0.025
dna repair GO:0006281 198 0.025
positive regulation of chromatin modification GO:1903310 30 0.025
regulation of histone methylation GO:0031060 16 0.024
embryo development ending in birth or egg hatching GO:0009792 34 0.024
Human Mouse
mitotic nuclear division GO:0007067 119 0.024
defense response GO:0006952 315 0.024
positive regulation of immune system process GO:0002684 283 0.024
regulation of secretion GO:0051046 194 0.024
Human
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.023
embryonic camera type eye formation GO:0060900 2 0.023
atp metabolic process GO:0046034 176 0.023
negative regulation of catalytic activity GO:0043086 335 0.023
limb development GO:0060173 23 0.023
Human
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.022
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.022
hematopoietic or lymphoid organ development GO:0048534 186 0.022
Human
signal transduction by phosphorylation GO:0023014 297 0.022
mapk cascade GO:0000165 288 0.021
response to ionizing radiation GO:0010212 65 0.021
neural tube closure GO:0001843 3 0.021
erythrocyte development GO:0048821 3 0.021
protein modification by small protein removal GO:0070646 92 0.020
protein dna complex assembly GO:0065004 64 0.020
proteasomal protein catabolic process GO:0010498 176 0.020
regulation of ras gtpase activity GO:0032318 128 0.020
nuclear transport GO:0051169 179 0.020
peptidyl lysine trimethylation GO:0018023 10 0.020
mitotic cell cycle phase transition GO:0044772 162 0.020
regulation of purine nucleotide metabolic process GO:1900542 264 0.020
intracellular receptor signaling pathway GO:0030522 104 0.020
organelle fission GO:0048285 149 0.020
single organism cellular localization GO:1902580 332 0.020
regulation of lymphocyte activation GO:0051249 103 0.019
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.019
intracellular estrogen receptor signaling pathway GO:0030520 23 0.019
regulation of kinase activity GO:0043549 314 0.019
cell cycle g1 s phase transition GO:0044843 80 0.019
ribonucleoprotein complex assembly GO:0022618 78 0.019
rna splicing via transesterification reactions GO:0000375 90 0.019
positive regulation of apoptotic process GO:0043065 246 0.019
regulation of transferase activity GO:0051338 355 0.018
positive regulation of cell cycle process GO:0090068 106 0.018
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.018
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 89 0.018
regulation of cytoplasmic transport GO:1903649 149 0.018
telencephalon development GO:0021537 17 0.018
negative regulation of cell death GO:0060548 345 0.018
Mouse
negative regulation of cell cycle phase transition GO:1901988 89 0.018
tube closure GO:0060606 3 0.018
negative regulation of chromatin silencing GO:0031936 4 0.018
regulation of proteolysis GO:0030162 293 0.018
cellular response to organic cyclic compound GO:0071407 127 0.017
regulation of cell development GO:0060284 161 0.017
regulation of response to wounding GO:1903034 101 0.017
regulation of gtp catabolic process GO:0033124 180 0.017
regulation of nucleotide catabolic process GO:0030811 205 0.017
guanosine containing compound catabolic process GO:1901069 239 0.017
gtp catabolic process GO:0006184 237 0.017
response to fungus GO:0009620 4 0.017
regulation of developmental growth GO:0048638 30 0.017
Fly
regulation of cellular ketone metabolic process by positive regulation of transcription from rna polymerase ii promoter GO:0072366 1 0.017
secretion by cell GO:0032940 226 0.017
Human
negative regulation of organelle organization GO:0010639 126 0.017
female sex differentiation GO:0046660 12 0.017
chromatin mediated maintenance of transcription GO:0048096 2 0.017
positive regulation of nucleotide catabolic process GO:0030813 185 0.017
regulation of ras protein signal transduction GO:0046578 155 0.017
circadian behavior GO:0048512 2 0.016
g2 m transition of mitotic cell cycle GO:0000086 41 0.016
regulation of protein ubiquitination GO:0031396 95 0.016
dephosphorylation GO:0016311 209 0.016
chromatin silencing GO:0006342 12 0.016
regulation of immunoglobulin production GO:0002637 4 0.016
regulation of protein localization GO:0032880 296 0.016
regulation of gtpase activity GO:0043087 180 0.016
negative regulation of phosphate metabolic process GO:0045936 267 0.016
regulation of multicellular organism growth GO:0040014 8 0.016
pancreatic juice secretion GO:0030157 4 0.016
negative regulation of cellular component movement GO:0051271 106 0.016
negative regulation of protein maturation GO:1903318 142 0.016
autophagy GO:0006914 88 0.016
in utero embryonic development GO:0001701 8 0.016
Human Mouse
dna integrity checkpoint GO:0031570 71 0.016
gtp metabolic process GO:0046039 239 0.015
isotype switching GO:0045190 3 0.015
cell cycle g2 m phase transition GO:0044839 43 0.015
spermatid differentiation GO:0048515 4 0.015
forebrain development GO:0030900 26 0.015
histone h4 k16 acetylation GO:0043984 14 0.015
positive regulation of chromosome organization GO:2001252 41 0.015
negative regulation of gene silencing by rna GO:0060967 3 0.015
regulation of cellular response to stress GO:0080135 244 0.015
regulation of mapk cascade GO:0043408 262 0.015
negative regulation of hydrolase activity GO:0051346 182 0.015
embryonic pattern specification GO:0009880 5 0.015
Fly
single organism carbohydrate metabolic process GO:0044723 193 0.015
g1 s transition of mitotic cell cycle GO:0000082 78 0.015
response to radiation GO:0009314 151 0.015
mrna transport GO:0051028 30 0.015
positive regulation of nucleotide metabolic process GO:0045981 230 0.015
rab protein signal transduction GO:0032482 4 0.014
regulation of establishment of protein localization GO:0070201 242 0.014
positive regulation of cellular catabolic process GO:0031331 284 0.014
organelle assembly GO:0070925 176 0.014
positive regulation of organelle organization GO:0010638 195 0.014
positive regulation of catabolic process GO:0009896 310 0.014
regulation of mrna processing GO:0050684 48 0.014
chromatin silencing at rdna GO:0000183 5 0.014
neuroblast proliferation GO:0007405 4 0.014
negative regulation of proteolysis GO:0045861 132 0.014
mitotic sister chromatid segregation GO:0000070 53 0.014
positive regulation of developmental growth GO:0048639 16 0.014
Fly
apoptotic signaling pathway GO:0097190 268 0.014
viral latency GO:0019042 1 0.014
protein monoubiquitination GO:0006513 39 0.014
peripheral nervous system development GO:0007422 2 0.014
embryonic eye morphogenesis GO:0048048 2 0.014
regulation of protein maturation GO:1903317 150 0.014
microtubule based process GO:0007017 210 0.014
ribonucleoside catabolic process GO:0042454 406 0.013
carbohydrate metabolic process GO:0005975 207 0.013
cellular macromolecule catabolic process GO:0044265 380 0.013
positive regulation of nucleoside metabolic process GO:0045979 186 0.013
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.013
regulation of neurogenesis GO:0050767 82 0.013
negative regulation of secretion GO:0051048 58 0.013
negative regulation of protein processing GO:0010955 142 0.013
modification dependent macromolecule catabolic process GO:0043632 212 0.013
ossification GO:0001503 121 0.013
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.013
regulation of cysteine type endopeptidase activity GO:2000116 127 0.013
guanosine containing compound metabolic process GO:1901068 244 0.013
positive regulation of cellular component biogenesis GO:0044089 158 0.013
response to abiotic stimulus GO:0009628 336 0.013
retina development in camera type eye GO:0060041 15 0.013
Human
positive regulation of transport GO:0051050 336 0.013
modification dependent protein catabolic process GO:0019941 209 0.013
response to uv GO:0009411 73 0.013
axis elongation GO:0003401 4 0.013
actin cytoskeleton organization GO:0030036 207 0.013
negative regulation of apoptotic process GO:0043066 316 0.013
Mouse
regulation of intracellular transport GO:0032386 195 0.013
regulation of transcription from rna polymerase i promoter GO:0006356 10 0.012
regulation of inflammatory response GO:0050727 46 0.012
spliceosomal snrnp assembly GO:0000387 28 0.012
regulation of small gtpase mediated signal transduction GO:0051056 156 0.012
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 0.012
regulation of methylation dependent chromatin silencing GO:0090308 3 0.012
regulation of protein transport GO:0051223 213 0.012
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.012
regulation of dna metabolic process GO:0051052 153 0.012
negative regulation of phosphorylation GO:0042326 174 0.012
cell growth GO:0016049 160 0.012
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.012
osteoblast differentiation GO:0001649 92 0.012
regulation of wnt signaling pathway GO:0030111 123 0.012
positive regulation of cell death GO:0010942 263 0.012
endocytosis GO:0006897 159 0.012
inflammatory response GO:0006954 79 0.012
positive regulation of immunoglobulin mediated immune response GO:0002891 4 0.012
appendage development GO:0048736 23 0.012
Human Fly
embryonic hemopoiesis GO:0035162 4 0.012
toxin transport GO:1901998 4 0.012
myeloid leukocyte differentiation GO:0002573 60 0.012
regulation of rab gtpase activity GO:0032313 39 0.012
morphogenesis of a polarized epithelium GO:0001738 3 0.012
positive regulation of gtp catabolic process GO:0033126 166 0.012
somatic recombination of immunoglobulin gene segments GO:0016447 4 0.012
regulation of cell growth GO:0001558 135 0.012
protein import into nucleus GO:0006606 104 0.011
positive regulation of immune response GO:0050778 159 0.011
regulation of protein kinase activity GO:0045859 289 0.011
telomere maintenance GO:0000723 32 0.011
otic vesicle development GO:0071599 1 0.011
single organism behavior GO:0044708 28 0.011
Fly
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.011
innate immune response GO:0045087 178 0.011
somatic diversification of immunoglobulins involved in immune response GO:0002208 3 0.011
regulation of peptidase activity GO:0052547 180 0.011
regulation of immune response GO:0050776 201 0.011
positive regulation of transporter activity GO:0032411 32 0.011
negative regulation of wnt signaling pathway GO:0030178 69 0.011

CHD8 disease predictions

Disease DO term ID Size Probability Func Analog Org
syndrome DOID:225 17 0.467
Human
gonadal disease DOID:2277 8 0.187
Human
endocrine system disease DOID:28 26 0.187
Human
reproductive system disease DOID:15 17 0.187
Human
sensory system disease DOID:0050155 203 0.045
eye and adnexa disease DOID:1492 150 0.045
nervous system disease DOID:863 431 0.045
musculoskeletal system disease DOID:17 223 0.042
myopathy DOID:423 104 0.040
muscular disease DOID:0080000 114 0.040
muscle tissue disease DOID:66 113 0.040
central nervous system disease DOID:331 186 0.028
neurodegenerative disease DOID:1289 102 0.028
muscular dystrophy DOID:9884 51 0.020
kallmann syndrome DOID:3614 5 0.018
Human
hypogonadism DOID:1924 5 0.018
Human
eye disease DOID:5614 149 0.014