Homo sapiens

122 known processes

CHEK1

CHK1 checkpoint homolog (S. pombe)

(Aliases: CHK1)

CHEK1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular response to dna damage stimulus GO:0006974 379 1.000
g2 dna damage checkpoint GO:0031572 26 0.999
dna damage checkpoint GO:0000077 68 0.999
dna repair GO:0006281 198 0.998
regulation of cell cycle phase transition GO:1901987 126 0.998
Zebrafish Rat
regulation of cell cycle GO:0051726 393 0.998
cell cycle phase transition GO:0044770 173 0.997
Zebrafish Mouse Rat
double strand break repair GO:0006302 101 0.996
dna integrity checkpoint GO:0031570 71 0.995
double strand break repair via homologous recombination GO:0000724 50 0.993
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.992
Zebrafish Rat
meiosis i GO:0007127 4 0.988
regulation of cell cycle process GO:0010564 266 0.982
response to radiation GO:0009314 151 0.979
Mouse
mitotic dna damage checkpoint GO:0044773 28 0.974
Zebrafish
negative regulation of mitotic cell cycle GO:0045930 102 0.973
cellular macromolecule catabolic process GO:0044265 380 0.972
mitotic cell cycle phase transition GO:0044772 162 0.962
Zebrafish Mouse Rat
negative regulation of cell cycle phase transition GO:1901988 89 0.953
Zebrafish Rat
mitotic dna integrity checkpoint GO:0044774 30 0.952
Zebrafish
purine nucleoside monophosphate metabolic process GO:0009126 186 0.947
mitotic cell cycle GO:0000278 326 0.944
meiotic nuclear division GO:0007126 10 0.941
negative regulation of cell cycle GO:0045786 193 0.935
dna catabolic process GO:0006308 49 0.931
cell cycle checkpoint GO:0000075 117 0.928
apoptotic signaling pathway GO:0097190 268 0.921
Zebrafish
negative regulation of cell cycle process GO:0010948 121 0.916
regulation of mitotic cell cycle GO:0007346 189 0.907
regulation of mitotic cell cycle phase transition GO:1901990 118 0.904
Zebrafish Rat
cellular response to radiation GO:0071478 65 0.896
Mouse
ribonucleoside monophosphate metabolic process GO:0009161 187 0.887
mitotic cell cycle process GO:1903047 286 0.887
regulation of response to dna damage stimulus GO:2001020 94 0.883
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.866
modification dependent protein catabolic process GO:0019941 209 0.853
negative regulation of dna metabolic process GO:0051053 57 0.824
Rat
recombinational repair GO:0000725 50 0.795
nucleoside triphosphate metabolic process GO:0009141 422 0.786
response to ionizing radiation GO:0010212 65 0.782
regulation of double strand break repair via homologous recombination GO:0010569 11 0.775
ribonucleoside monophosphate catabolic process GO:0009158 158 0.770
atp metabolic process GO:0046034 176 0.758
ribonucleoside triphosphate catabolic process GO:0009203 391 0.731
response to abiotic stimulus GO:0009628 336 0.723
female gamete generation GO:0007292 2 0.710
nucleoside monophosphate catabolic process GO:0009125 159 0.705
cellular response to abiotic stimulus GO:0071214 117 0.699
meiotic chromosome segregation GO:0045132 4 0.689
dna dependent dna replication GO:0006261 44 0.683
intrinsic apoptotic signaling pathway GO:0097193 127 0.671
Zebrafish
organelle fission GO:0048285 149 0.670
nucleoside monophosphate metabolic process GO:0009123 191 0.664
peptidyl serine phosphorylation GO:0018105 101 0.632
mitotic nuclear division GO:0007067 119 0.632
atp catabolic process GO:0006200 157 0.631
double strand break repair via single strand annealing GO:0045002 4 0.618
nuclear division GO:0000280 128 0.613
mitotic cell cycle checkpoint GO:0007093 68 0.612
Zebrafish
regulation of cellular response to stress GO:0080135 244 0.609
chromosome segregation GO:0007059 114 0.604
microtubule based process GO:0007017 210 0.595
regulation of dna metabolic process GO:0051052 153 0.565
male meiosis GO:0007140 1 0.533
cellular component morphogenesis GO:0032989 314 0.524
purine ribonucleotide catabolic process GO:0009154 404 0.518
ribonucleoside catabolic process GO:0042454 406 0.514
g2 m transition of mitotic cell cycle GO:0000086 41 0.507
Mouse Rat
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.503
meiotic cell cycle GO:0051321 13 0.502
cellular protein catabolic process GO:0044257 261 0.489
cell division GO:0051301 168 0.483
chromatin modification GO:0016568 298 0.473
purine nucleoside monophosphate catabolic process GO:0009128 158 0.462
dna recombination GO:0006310 77 0.460
purine ribonucleoside catabolic process GO:0046130 398 0.435
positive regulation of cell proliferation GO:0008284 301 0.434
regulation of proteasomal protein catabolic process GO:0061136 87 0.432
purine nucleoside triphosphate catabolic process GO:0009146 392 0.426
sister chromatid segregation GO:0000819 54 0.421
non recombinational repair GO:0000726 14 0.421
peptidyl serine modification GO:0018209 106 0.412
organophosphate catabolic process GO:0046434 430 0.405
positive regulation of programmed cell death GO:0043068 249 0.401
protein ubiquitination GO:0016567 314 0.388
protein modification by small protein conjugation GO:0032446 342 0.383
dna double strand break processing GO:0000729 10 0.369
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.361
covalent chromatin modification GO:0016569 254 0.360
purine nucleoside triphosphate metabolic process GO:0009144 412 0.340
regulation of anatomical structure morphogenesis GO:0022603 286 0.326
cellular macromolecular complex assembly GO:0034622 324 0.322
nucleoside triphosphate catabolic process GO:0009143 394 0.300
cell development GO:0048468 328 0.290
neuron projection development GO:0031175 106 0.290
tube morphogenesis GO:0035239 95 0.289
regulation of cell division GO:0051302 116 0.289
post embryonic development GO:0009791 2 0.280
positive regulation of mitotic cell cycle GO:0045931 60 0.280
regulation of protein catabolic process GO:0042176 155 0.279
tube development GO:0035295 125 0.276
positive regulation of cell cycle process GO:0090068 106 0.273
ribonucleoside triphosphate metabolic process GO:0009199 412 0.270
nucleotide catabolic process GO:0009166 408 0.270
ubiquitin dependent protein catabolic process GO:0006511 206 0.264
purine nucleoside catabolic process GO:0006152 398 0.264
regulation of transferase activity GO:0051338 355 0.258
ribonucleotide catabolic process GO:0009261 405 0.253
nucleoside catabolic process GO:0009164 408 0.252
regulation of cell morphogenesis GO:0022604 153 0.251
regulation of microtubule based process GO:0032886 74 0.249
immune system development GO:0002520 195 0.242
dna geometric change GO:0032392 32 0.241
nucleoside phosphate catabolic process GO:1901292 412 0.240
glycosyl compound catabolic process GO:1901658 413 0.238
response to uv GO:0009411 73 0.238
Mouse
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.236
regulation of protein stability GO:0031647 87 0.229
cell morphogenesis GO:0000902 296 0.223
regulation of centrosome cycle GO:0046605 15 0.220
oogenesis GO:0048477 2 0.220
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.219
posttranscriptional regulation of gene expression GO:0010608 213 0.218
protein catabolic process GO:0030163 325 0.209
dna replication GO:0006260 116 0.207
regulation of protein kinase activity GO:0045859 289 0.199
dna conformation change GO:0071103 113 0.198
protein autophosphorylation GO:0046777 123 0.196
cytokinesis GO:0000910 96 0.192
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.191
response to light stimulus GO:0009416 87 0.189
Mouse
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.186
Zebrafish
purine containing compound catabolic process GO:0072523 411 0.183
centrosome cycle GO:0007098 32 0.182
negative regulation of cell death GO:0060548 345 0.181
cell projection organization GO:0030030 252 0.180
cell projection morphogenesis GO:0048858 129 0.180
signal transduction by p53 class mediator GO:0072331 72 0.177
positive regulation of cellular catabolic process GO:0031331 284 0.176
vesicle mediated transport GO:0016192 371 0.175
cellular response to ionizing radiation GO:0071479 32 0.173
sex determination GO:0007530 3 0.173
endomembrane system organization GO:0010256 196 0.172
signal transduction in response to dna damage GO:0042770 57 0.163
regulation of dna replication GO:0006275 68 0.157
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.155
negative regulation of apoptotic process GO:0043066 316 0.155
regulation of proteolysis GO:0030162 293 0.154
regulation of mitosis GO:0007088 63 0.154
regulation of cell cycle g1 s phase transition GO:1902806 42 0.152
embryo development GO:0009790 123 0.150
reproduction GO:0000003 63 0.150
mitotic sister chromatid segregation GO:0000070 53 0.147
positive regulation of cell cycle GO:0045787 140 0.147
positive regulation of organelle organization GO:0010638 195 0.143
response to hypoxia GO:0001666 96 0.143
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.139
purine ribonucleoside metabolic process GO:0046128 437 0.137
positive regulation of protein kinase activity GO:0045860 190 0.133
positive regulation of phosphorylation GO:0042327 394 0.133
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.131
meiotic cell cycle process GO:1903046 8 0.131
neuron differentiation GO:0030182 138 0.130
developmental process involved in reproduction GO:0003006 66 0.126
regulation of chromosome organization GO:0033044 103 0.125
Mouse
mitotic dna replication checkpoint GO:0033314 2 0.124
cellular amine metabolic process GO:0044106 41 0.118
negative regulation of transcription involved in g1 s transition of mitotic cell cycle GO:0071930 2 0.116
determination of adult lifespan GO:0008340 2 0.116
positive regulation of transferase activity GO:0051347 227 0.113
organelle assembly GO:0070925 176 0.113
microtubule cytoskeleton organization GO:0000226 176 0.112
chromatin organization GO:0006325 351 0.111
double strand break repair via nonhomologous end joining GO:0006303 10 0.110
regulation of chromosome segregation GO:0051983 44 0.104
nervous system development GO:0007399 293 0.104
mitotic g2 m transition checkpoint GO:0044818 9 0.102
Zebrafish
positive regulation of hydrolase activity GO:0051345 331 0.100
regulation of protein serine threonine kinase activity GO:0071900 179 0.099
regulation of cellular protein catabolic process GO:1903362 96 0.099
negative regulation of cellular component organization GO:0051129 235 0.096
positive regulation of kinase activity GO:0033674 204 0.095
small gtpase mediated signal transduction GO:0007264 78 0.095
single organism reproductive process GO:0044702 98 0.094
negative regulation of protein metabolic process GO:0051248 391 0.088
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.084
histone modification GO:0016570 251 0.084
regulation of meiotic cell cycle GO:0051445 4 0.083
regulation of g1 s transition of mitotic cell cycle GO:2000045 40 0.083
regulation of cellular component movement GO:0051270 334 0.080
photoreceptor cell differentiation GO:0046530 2 0.080
dna damage induced protein phosphorylation GO:0006975 5 0.080
regulation of microtubule cytoskeleton organization GO:0070507 61 0.080
regulation of locomotion GO:0040012 329 0.078
oocyte differentiation GO:0009994 2 0.076
embryo development ending in birth or egg hatching GO:0009792 34 0.075
sensory organ development GO:0007423 52 0.075
mismatch repair GO:0006298 15 0.075
regulation of intracellular transport GO:0032386 195 0.074
gonad development GO:0008406 34 0.074
epithelium development GO:0060429 227 0.074
response to organonitrogen compound GO:0010243 156 0.072
Rat
maintenance of location in cell GO:0051651 62 0.072
cell part morphogenesis GO:0032990 137 0.070
intracellular protein transport GO:0006886 270 0.069
regulation of double strand break repair GO:2000779 22 0.067
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 36 0.067
regulation of cellular amine metabolic process GO:0033238 11 0.067
developmental programmed cell death GO:0010623 3 0.066
negative regulation of cellular protein metabolic process GO:0032269 353 0.065
single organism cellular localization GO:1902580 332 0.063
cell cycle g2 m phase transition GO:0044839 43 0.062
Mouse Rat
centrosome organization GO:0051297 58 0.061
reproductive process GO:0022414 106 0.060
response to purine containing compound GO:0014074 40 0.060
Rat
chromosome separation GO:0051304 23 0.060
cell type specific apoptotic process GO:0097285 125 0.057
microtubule organizing center organization GO:0031023 62 0.057
lymphocyte activation GO:0046649 133 0.057
metaphase anaphase transition of mitotic cell cycle GO:0007091 21 0.057
purine nucleotide catabolic process GO:0006195 405 0.055
regeneration GO:0031099 4 0.055
dna duplex unwinding GO:0032508 30 0.055
positive regulation of protein phosphorylation GO:0001934 313 0.054
protein targeting GO:0006605 187 0.054
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.053
oocyte development GO:0048599 1 0.052
regulation of protein ubiquitination GO:0031396 95 0.051
proteasomal protein catabolic process GO:0010498 176 0.051
positive regulation of cell differentiation GO:0045597 211 0.051
negative regulation of programmed cell death GO:0043069 321 0.050
protein processing GO:0016485 226 0.050
regulation of protein maturation GO:1903317 150 0.050
telomere maintenance GO:0000723 32 0.049
negative regulation of mitotic metaphase anaphase transition GO:0045841 17 0.049
cellular component disassembly GO:0022411 92 0.048
peptidyl tyrosine phosphorylation GO:0018108 170 0.048
immune response GO:0006955 307 0.048
g1 s transition of mitotic cell cycle GO:0000082 78 0.048
multi organism reproductive process GO:0044703 54 0.047
actin filament based process GO:0030029 224 0.047
leukocyte activation GO:0045321 164 0.046
positive regulation of cell development GO:0010720 92 0.044
neuron projection morphogenesis GO:0048812 50 0.044
neuron development GO:0048666 113 0.044
positive regulation of meiotic cell cycle GO:0051446 2 0.044
positive regulation of apoptotic process GO:0043065 246 0.044
cell cycle g1 s phase transition GO:0044843 80 0.043
positive regulation of cellular component organization GO:0051130 376 0.043
dna catabolic process exonucleolytic GO:0000738 17 0.043
generation of neurons GO:0048699 152 0.042
negative regulation of response to dna damage stimulus GO:2001021 33 0.042
cell activation GO:0001775 213 0.041
modification dependent macromolecule catabolic process GO:0043632 212 0.041
neurogenesis GO:0022008 169 0.040
cellular amino acid metabolic process GO:0006520 116 0.040
regulation of wnt signaling pathway GO:0030111 123 0.039
positive regulation of developmental process GO:0051094 314 0.039
regulation of nucleocytoplasmic transport GO:0046822 98 0.038
regulation of cytoplasmic transport GO:1903649 149 0.037
anatomical structure formation involved in morphogenesis GO:0048646 284 0.037
negative regulation of proteolysis GO:0045861 132 0.037
positive regulation of transport GO:0051050 336 0.036
regulation of cytoskeleton organization GO:0051493 177 0.036
cellular homeostasis GO:0019725 196 0.036
negative regulation of g1 s transition of mitotic cell cycle GO:2000134 29 0.036
multicellular organismal aging GO:0010259 3 0.035
regulation of centrosome duplication GO:0010824 14 0.035
positive regulation of cell death GO:0010942 263 0.035
epithelial tube morphogenesis GO:0060562 38 0.035
b cell activation GO:0042113 33 0.035
multicellular organism reproduction GO:0032504 42 0.034
regulation of cellular component biogenesis GO:0044087 281 0.034
negative regulation of protein phosphorylation GO:0001933 140 0.034
regulation of organelle assembly GO:1902115 40 0.033
regulation of cell development GO:0060284 161 0.033
dna packaging GO:0006323 77 0.033
regulation of nervous system development GO:0051960 88 0.033
regulation of dna dependent dna replication GO:0090329 19 0.033
regulation of neuron differentiation GO:0045664 70 0.033
cellular response to oxygen containing compound GO:1901701 276 0.033
regulation of cellular component size GO:0032535 82 0.031
regulation of protein import into nucleus GO:0042306 78 0.031
regulation of mitotic sister chromatid separation GO:0010965 27 0.031
negative regulation of transferase activity GO:0051348 124 0.030
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 37 0.029
negative regulation of cell cycle g1 s phase transition GO:1902807 29 0.029
maintenance of location GO:0051235 112 0.029
regulation of establishment of protein localization GO:0070201 242 0.029
positive regulation of proteolysis GO:0045862 142 0.028
base excision repair GO:0006284 21 0.028
regulation of cell differentiation GO:0045595 393 0.027
regulation of protein complex assembly GO:0043254 147 0.027
ras protein signal transduction GO:0007265 73 0.027
mrna metabolic process GO:0016071 175 0.027
regulation of ion transport GO:0043269 189 0.027
response to inorganic substance GO:0010035 127 0.026
response to oxygen containing compound GO:1901700 369 0.026
rna processing GO:0006396 255 0.026
negative regulation of phosphorus metabolic process GO:0010563 267 0.026
negative regulation of intracellular signal transduction GO:1902532 183 0.025
hematopoietic or lymphoid organ development GO:0048534 186 0.025
hemopoiesis GO:0030097 180 0.025
chromosome condensation GO:0030261 15 0.025
regulation of circadian rhythm GO:0042752 11 0.025
wnt signaling pathway GO:0016055 156 0.024
negative regulation of g2 m transition of mitotic cell cycle GO:0010972 9 0.024
Rat
negative regulation of catalytic activity GO:0043086 335 0.023
regulation of endopeptidase activity GO:0052548 170 0.023
morphogenesis of an epithelium GO:0002009 60 0.023
dna catabolic process endonucleolytic GO:0000737 37 0.023
dephosphorylation GO:0016311 209 0.023
regulation of neuron projection development GO:0010975 57 0.023
blastocyst development GO:0001824 3 0.022
positive regulation of neurogenesis GO:0050769 49 0.022
response to drug GO:0042493 81 0.022
receptor mediated endocytosis GO:0006898 84 0.022
microtubule anchoring GO:0034453 24 0.021
dna damage response signal transduction by p53 class mediator GO:0030330 44 0.021
sexual reproduction GO:0019953 37 0.021
regulation of dna repair GO:0006282 47 0.021
membrane organization GO:0061024 292 0.020
circulatory system development GO:0072359 262 0.020
intra s dna damage checkpoint GO:0031573 4 0.020
dna biosynthetic process GO:0071897 40 0.020
Rat
anatomical structure homeostasis GO:0060249 100 0.020
regulation of growth GO:0040008 165 0.020
tissue morphogenesis GO:0048729 96 0.020
endocytosis GO:0006897 159 0.020
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.020
reciprocal meiotic recombination GO:0007131 4 0.019
wound healing GO:0042060 115 0.019
blood circulation GO:0008015 113 0.019
urogenital system development GO:0001655 65 0.019
cell cycle dna replication GO:0044786 11 0.019
cell fate determination GO:0001709 3 0.019
reproductive structure development GO:0048608 55 0.019
cytoplasmic transport GO:0016482 379 0.019
gastrulation GO:0007369 51 0.018
cell adhesion GO:0007155 325 0.018
negative regulation of protein processing GO:0010955 142 0.018
regulation of mitotic metaphase anaphase transition GO:0030071 26 0.018
negative regulation of dna recombination GO:0045910 6 0.018
embryonic morphogenesis GO:0048598 85 0.018
tissue regeneration GO:0042246 3 0.018
positive regulation of fibroblast proliferation GO:0048146 21 0.017
regulation of embryonic development GO:0045995 20 0.017
negative regulation of protein maturation GO:1903318 142 0.017
microtubule cytoskeleton organization involved in mitosis GO:1902850 15 0.017
amine metabolic process GO:0009308 44 0.017
regulation of cell migration GO:0030334 289 0.016
development of primary sexual characteristics GO:0045137 35 0.016
regulation of cellular respiration GO:0043457 4 0.016
lymphocyte proliferation GO:0046651 70 0.016
negative regulation of protein ubiquitination GO:0031397 35 0.016
telomere organization GO:0032200 33 0.016
morphogenesis of a branching epithelium GO:0061138 20 0.016
regulation of ligase activity GO:0051340 29 0.016
regulation of sister chromatid segregation GO:0033045 27 0.016
metaphase plate congression GO:0051310 18 0.016
multicellular organismal reproductive process GO:0048609 40 0.016
positive regulation of response to dna damage stimulus GO:2001022 43 0.016
negative regulation of cellular protein catabolic process GO:1903363 38 0.016
regulation of mitotic sister chromatid segregation GO:0033047 27 0.015
intracellular receptor signaling pathway GO:0030522 104 0.015
regulation of anatomical structure size GO:0090066 101 0.015
regulation of cell cycle g2 m phase transition GO:1902749 22 0.015
Rat
lipid metabolic process GO:0006629 381 0.015
intracellular mrna localization GO:0008298 1 0.015
centrosome duplication GO:0051298 28 0.015
growth GO:0040007 202 0.015
regulation of dna recombination GO:0000018 23 0.015
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 25 0.015
gene conversion GO:0035822 1 0.015
regulation of ubiquitin protein transferase activity GO:0051438 28 0.015
regulation of nuclear division GO:0051783 65 0.015
branching morphogenesis of an epithelial tube GO:0048754 19 0.015
peptidyl tyrosine modification GO:0018212 170 0.015
negative regulation of chromosome segregation GO:0051985 18 0.014
regulation of apoptotic signaling pathway GO:2001233 175 0.014
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.014
digestive system development GO:0055123 75 0.014
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 35 0.014
response to transition metal nanoparticle GO:1990267 29 0.014
negative regulation of cell cycle g2 m phase transition GO:1902750 10 0.014
Rat
cellular protein complex assembly GO:0043623 188 0.014
positive regulation of protein transport GO:0051222 135 0.014
molting cycle GO:0042303 28 0.014
biological adhesion GO:0022610 331 0.014
response to nitrogen compound GO:1901698 184 0.014
Rat
macromolecule methylation GO:0043414 97 0.013
sister chromatid biorientation GO:0031134 2 0.013
oocyte maturation GO:0001556 1 0.013
regulation of protein processing GO:0070613 150 0.013
regulation of fibroblast proliferation GO:0048145 32 0.013
mitotic cytokinesis GO:0000281 19 0.013
cytoskeleton dependent cytokinesis GO:0061640 22 0.013
isotype switching GO:0045190 3 0.013
ribosome assembly GO:0042255 9 0.013
positive regulation of endopeptidase activity GO:0010950 84 0.013
regulation of cysteine type endopeptidase activity GO:2000116 127 0.013
protein polymerization GO:0051258 71 0.013
response to decreased oxygen levels GO:0036293 96 0.013
nuclear transport GO:0051169 179 0.013
cell morphogenesis involved in differentiation GO:0000904 144 0.013
negative regulation of protein modification process GO:0031400 200 0.012
centriole replication GO:0007099 13 0.012
response to gamma radiation GO:0010332 14 0.012
mrna processing GO:0006397 133 0.012
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.012
regulation of protein targeting GO:1903533 91 0.012
angiogenesis GO:0001525 147 0.012
postreplication repair GO:0006301 12 0.012
thymocyte apoptotic process GO:0070242 2 0.012
somatic diversification of immunoglobulins involved in immune response GO:0002208 3 0.012
synaptic transmission involved in micturition GO:0060084 2 0.012
cellular process involved in reproduction in multicellular organism GO:0022412 15 0.012
golgi organization GO:0007030 38 0.012
regulation of dna damage response signal transduction by p53 class mediator GO:0043516 20 0.012
regulation of cellular ketone metabolic process GO:0010565 50 0.012
reciprocal dna recombination GO:0035825 4 0.012
circadian rhythm GO:0007623 21 0.012
cellular chemical homeostasis GO:0055082 180 0.012
regulation of intracellular protein transport GO:0033157 123 0.012
regulation of neurogenesis GO:0050767 82 0.012
protein acylation GO:0043543 138 0.012
Mouse
activation of protein kinase activity GO:0032147 90 0.011
digestive tract development GO:0048565 75 0.011
signal transduction by phosphorylation GO:0023014 297 0.011
peptidyl threonine modification GO:0018210 45 0.011
smoothened signaling pathway GO:0007224 14 0.011
cellular lipid metabolic process GO:0044255 303 0.011
regulation of cell motility GO:2000145 299 0.011
internal protein amino acid acetylation GO:0006475 101 0.011
Mouse
translesion synthesis GO:0019985 8 0.011
regulation of g2 m transition of mitotic cell cycle GO:0010389 20 0.011
Rat
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.011
response to wounding GO:0009611 168 0.010
regulation of dendrite morphogenesis GO:0048814 11 0.010
negative regulation of t cell apoptotic process GO:0070233 4 0.010
positive regulation of dna metabolic process GO:0051054 73 0.010
spermatogenesis GO:0007283 22 0.010
mitotic g2 dna damage checkpoint GO:0007095 7 0.010
Zebrafish
negative regulation of protein serine threonine kinase activity GO:0071901 57 0.010
negative regulation of kinase activity GO:0033673 106 0.010
positive regulation of nervous system development GO:0051962 54 0.010
negative regulation of protein catabolic process GO:0042177 59 0.010
protein oligomerization GO:0051259 173 0.010

CHEK1 disease predictions

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 167 0.575
disease of cellular proliferation DOID:14566 174 0.575
organ system cancer DOID:0050686 164 0.575
breast cancer DOID:1612 21 0.289
thoracic cancer DOID:5093 21 0.289
immune system disease DOID:2914 155 0.029
reproductive organ cancer DOID:193 23 0.015
female reproductive organ cancer DOID:120 10 0.015
hematopoietic system disease DOID:74 100 0.014