Homo sapiens

212 known processes

CHEK2

CHK2 checkpoint homolog (S. pombe)

(Aliases: PP1425,CDS1,CHK2,RAD53,HuCds1,LFS2)

CHEK2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular response to dna damage stimulus GO:0006974 379 1.000
double strand break repair GO:0006302 101 0.993
dna repair GO:0006281 198 0.992
dna damage induced protein phosphorylation GO:0006975 5 0.968
regulation of cell cycle GO:0051726 393 0.964
histone h3 acetylation GO:0043966 45 0.963
dna integrity checkpoint GO:0031570 71 0.960
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.958
negative regulation of mitotic cell cycle GO:0045930 102 0.955
intrinsic apoptotic signaling pathway GO:0097193 127 0.918
male meiosis GO:0007140 1 0.917
negative regulation of cell cycle phase transition GO:1901988 89 0.901
regulation of mitotic cell cycle GO:0007346 189 0.898
dna damage checkpoint GO:0000077 68 0.895
negative regulation of cell cycle GO:0045786 193 0.892
developmental programmed cell death GO:0010623 3 0.887
Fly
g1 s transition of mitotic cell cycle GO:0000082 78 0.886
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.844
dna damage response signal transduction by p53 class mediator GO:0030330 44 0.838
chromatin organization GO:0006325 351 0.831
signal transduction by p53 class mediator GO:0072331 72 0.829
Fly
double strand break repair via homologous recombination GO:0000724 50 0.821
regulation of cell cycle phase transition GO:1901987 126 0.807
regulation of cell cycle process GO:0010564 266 0.804
response to radiation GO:0009314 151 0.796
Mouse Fly
signal transduction in response to dna damage GO:0042770 57 0.752
nuclear division GO:0000280 128 0.750
mitotic dna damage checkpoint GO:0044773 28 0.748
response to organic cyclic compound GO:0014070 204 0.744
histone threonine phosphorylation GO:0035405 7 0.735
spindle assembly GO:0051225 29 0.730
chromatin modification GO:0016568 298 0.714
apoptotic signaling pathway GO:0097190 268 0.713
chromosome segregation GO:0007059 114 0.703
Worm
positive regulation of cell cycle process GO:0090068 106 0.700
post embryonic development GO:0009791 2 0.692
regulation of g1 s transition of mitotic cell cycle GO:2000045 40 0.684
cell cycle checkpoint GO:0000075 117 0.676
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 37 0.674
Fly
negative regulation of cell cycle process GO:0010948 121 0.666
mitotic dna integrity checkpoint GO:0044774 30 0.663
internal peptidyl lysine acetylation GO:0018393 97 0.660
dna geometric change GO:0032392 32 0.637
double strand break repair via single strand annealing GO:0045002 4 0.609
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.597
Fly
mitotic g1 dna damage checkpoint GO:0031571 17 0.596
cellular protein catabolic process GO:0044257 261 0.596
histone modification GO:0016570 251 0.584
dna dependent dna replication GO:0006261 44 0.581
positive regulation of cell cycle GO:0045787 140 0.579
histone h4 acetylation GO:0043967 47 0.572
negative regulation of g1 s transition of mitotic cell cycle GO:2000134 29 0.565
cellular response to caffeine GO:0071313 3 0.551
recombinational repair GO:0000725 50 0.551
positive regulation of meiotic cell cycle GO:0051446 2 0.519
regulation of cell cycle arrest GO:0071156 36 0.510
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.482
mitotic centrosome separation GO:0007100 1 0.480
g1 dna damage checkpoint GO:0044783 18 0.470
regulation of cellular response to stress GO:0080135 244 0.460
Fly
protein modification by small protein conjugation GO:0032446 342 0.457
regulation of mitotic cell cycle phase transition GO:1901990 118 0.455
mitotic cell cycle checkpoint GO:0007093 68 0.447
meiotic chromosome segregation GO:0045132 4 0.442
Worm
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.441
covalent chromatin modification GO:0016569 254 0.433
microtubule cytoskeleton organization GO:0000226 176 0.432
signal transduction involved in cell cycle checkpoint GO:0072395 16 0.419
positive regulation of cell cycle arrest GO:0071158 23 0.406
intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator GO:0042771 23 0.400
g2 dna damage checkpoint GO:0031572 26 0.390
negative regulation of cell proliferation GO:0008285 228 0.381
mitotic g1 s transition checkpoint GO:0044819 17 0.376
mitotic cell cycle phase transition GO:0044772 162 0.373
regulation of cell morphogenesis GO:0022604 153 0.372
endomembrane system organization GO:0010256 196 0.363
zymogen activation GO:0031638 70 0.361
Fly
regulation of response to dna damage stimulus GO:2001020 94 0.354
Fly
negative regulation of cell cycle g1 s phase transition GO:1902807 29 0.349
ubiquitin dependent protein catabolic process GO:0006511 206 0.346
protein ubiquitination GO:0016567 314 0.341
cellular amine metabolic process GO:0044106 41 0.327
chemical homeostasis GO:0048878 306 0.321
dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9 0.318
dna recombination GO:0006310 77 0.318
dna double strand break processing GO:0000729 10 0.315
lipid biosynthetic process GO:0008610 177 0.313
cell cycle phase transition GO:0044770 173 0.309
dna duplex unwinding GO:0032508 30 0.305
cellular homeostasis GO:0019725 196 0.304
regulation of proteolysis GO:0030162 293 0.302
Fly
internal protein amino acid acetylation GO:0006475 101 0.289
nucleotide excision repair GO:0006289 31 0.286
mitotic cell cycle GO:0000278 326 0.279
regulation of mitosis GO:0007088 63 0.276
regulation of cytokinesis GO:0032465 45 0.274
cellular chemical homeostasis GO:0055082 180 0.272
dna catabolic process GO:0006308 49 0.271
dna catabolic process exonucleolytic GO:0000738 17 0.270
regulation of cell development GO:0060284 161 0.268
positive regulation of peptidase activity GO:0010952 88 0.268
Fly
regulation of kinase activity GO:0043549 314 0.260
female gamete generation GO:0007292 2 0.252
signal transduction involved in mitotic g1 dna damage checkpoint GO:0072431 10 0.247
cytokinesis GO:0000910 96 0.247
cell division GO:0051301 168 0.238
negative regulation of cell death GO:0060548 345 0.237
membrane organization GO:0061024 292 0.237
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.236
golgi disassembly GO:0090166 2 0.235
response to caffeine GO:0031000 3 0.234
cellular response to uv GO:0034644 32 0.232
negative regulation of protein metabolic process GO:0051248 391 0.231
positive regulation of proteolysis GO:0045862 142 0.224
Fly
cellular response to purine containing compound GO:0071415 3 0.221
positive regulation of cell proliferation GO:0008284 301 0.219
signal transduction involved in dna damage checkpoint GO:0072422 15 0.217
modification dependent protein catabolic process GO:0019941 209 0.215
guanosine containing compound catabolic process GO:1901069 239 0.213
regulation of meiotic cell cycle GO:0051445 4 0.210
spindle midzone assembly GO:0051255 4 0.207
regulation of nucleoside metabolic process GO:0009118 209 0.206
protein processing GO:0016485 226 0.204
Fly
signal transduction involved in mitotic dna integrity checkpoint GO:1902403 13 0.203
purine nucleoside triphosphate catabolic process GO:0009146 392 0.201
intracellular signal transduction involved in g1 dna damage checkpoint GO:1902400 10 0.192
dna conformation change GO:0071103 113 0.187
negative regulation of phosphorylation GO:0042326 174 0.185
regeneration GO:0031099 4 0.182
signal transduction involved in mitotic cell cycle checkpoint GO:0072413 13 0.181
response to purine containing compound GO:0014074 40 0.180
regulation of cell cycle g1 s phase transition GO:1902806 42 0.179
response to xenobiotic stimulus GO:0009410 30 0.177
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.177
circadian regulation of gene expression GO:0032922 8 0.176
small gtpase mediated signal transduction GO:0007264 78 0.176
peptidyl threonine phosphorylation GO:0018107 41 0.176
androgen biosynthetic process GO:0006702 3 0.172
peptidyl lysine acetylation GO:0018394 101 0.172
determination of adult lifespan GO:0008340 2 0.172
peptidyl serine phosphorylation GO:0018105 101 0.172
cell cycle g1 s phase transition GO:0044843 80 0.169
centrosome separation GO:0051299 3 0.159
single organism membrane organization GO:0044802 268 0.158
blastocyst development GO:0001824 3 0.156
organelle disassembly GO:1903008 9 0.151
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 36 0.150
cation homeostasis GO:0055080 189 0.150
peptidyl lysine modification GO:0018205 144 0.149
dna replication GO:0006260 116 0.147
modification dependent macromolecule catabolic process GO:0043632 212 0.145
negative regulation of transcription involved in g1 s transition of mitotic cell cycle GO:0071930 2 0.143
cellular component morphogenesis GO:0032989 314 0.142
organelle fission GO:0048285 149 0.142
spindle organization GO:0007051 53 0.139
mitotic cell cycle process GO:1903047 286 0.139
protein acylation GO:0043543 138 0.139
response to nitrogen compound GO:1901698 184 0.137
protein catabolic process GO:0030163 325 0.134
regulation of dna metabolic process GO:0051052 153 0.134
negative regulation of transferase activity GO:0051348 124 0.133
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.131
regulation of microtubule based process GO:0032886 74 0.129
proteasomal protein catabolic process GO:0010498 176 0.128
cell cycle arrest GO:0007050 71 0.124
cellular response to light stimulus GO:0071482 34 0.121
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.121
Fly
anatomical structure formation involved in morphogenesis GO:0048646 284 0.119
meiosis i GO:0007127 4 0.118
actin filament organization GO:0007015 128 0.118
negative regulation of phosphorus metabolic process GO:0010563 267 0.117
oocyte differentiation GO:0009994 2 0.116
cellular response to radiation GO:0071478 65 0.116
Fly
oocyte maturation GO:0001556 1 0.115
glycoprotein biosynthetic process GO:0009101 91 0.113
regulation of centrosome cycle GO:0046605 15 0.112
ion homeostasis GO:0050801 230 0.112
regulation of cellular component biogenesis GO:0044087 281 0.108
regulation of transferase activity GO:0051338 355 0.108
purine ribonucleoside metabolic process GO:0046128 437 0.107
heart development GO:0007507 95 0.106
negative regulation of mitotic metaphase anaphase transition GO:0045841 17 0.105
posttranscriptional regulation of gene expression GO:0010608 213 0.104
metal ion homeostasis GO:0055065 169 0.104
response to hypoxia GO:0001666 96 0.103
ribonucleoside catabolic process GO:0042454 406 0.101
negative regulation of cellular protein metabolic process GO:0032269 353 0.100
regulation of cell division GO:0051302 116 0.098
regulation of protein localization GO:0032880 296 0.097
regulation of cell diameter GO:0060305 1 0.096
negative regulation of proteolysis GO:0045861 132 0.095
ras protein signal transduction GO:0007265 73 0.094
regulation of protein ubiquitination GO:0031396 95 0.094
embryo development GO:0009790 123 0.094
Worm
positive regulation of endopeptidase activity GO:0010950 84 0.093
Fly
response to abiotic stimulus GO:0009628 336 0.092
Mouse Fly
protein acetylation GO:0006473 116 0.092
cellular macromolecule catabolic process GO:0044265 380 0.091
positive regulation of hydrolase activity GO:0051345 331 0.090
Fly
histone phosphorylation GO:0016572 16 0.090
cellular lipid metabolic process GO:0044255 303 0.089
regulation of cellular amine metabolic process GO:0033238 11 0.088
regulation of organelle assembly GO:1902115 40 0.087
non recombinational repair GO:0000726 14 0.086
signal transduction by phosphorylation GO:0023014 297 0.085
regulation of double strand break repair GO:2000779 22 0.084
single organism cellular localization GO:1902580 332 0.083
peptidyl threonine modification GO:0018210 45 0.082
negative regulation of cellular component organization GO:0051129 235 0.081
rhythmic behavior GO:0007622 2 0.080
i kappab kinase nf kappab signaling GO:0007249 166 0.080
signal transduction involved in dna integrity checkpoint GO:0072401 15 0.078
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 49 0.076
Fly
microtubule based process GO:0007017 210 0.075
regulation of signal transduction by p53 class mediator GO:1901796 26 0.075
positive regulation of defense response GO:0031349 87 0.074
meiotic chromosome separation GO:0051307 3 0.073
secretion GO:0046903 254 0.073
negative regulation of phosphate metabolic process GO:0045936 267 0.071
response to organonitrogen compound GO:0010243 156 0.070
glycoprotein metabolic process GO:0009100 110 0.070
ribonucleoside monophosphate metabolic process GO:0009161 187 0.070
organelle inheritance GO:0048308 2 0.069
morphogenesis of a branching epithelium GO:0061138 20 0.069
calcium ion homeostasis GO:0055074 122 0.069
regulation of innate immune response GO:0045088 97 0.066
vesicle mediated transport GO:0016192 371 0.066
positive regulation of phosphorylation GO:0042327 394 0.066
reproductive process GO:0022414 106 0.066
Fly
regulation of protein stability GO:0031647 87 0.066
regulation of protein serine threonine kinase activity GO:0071900 179 0.065
negative regulation of catalytic activity GO:0043086 335 0.065
nervous system development GO:0007399 293 0.063
response to ionizing radiation GO:0010212 65 0.063
Mouse Fly
negative regulation of kinase activity GO:0033673 106 0.062
regulation of cellular ketone metabolic process GO:0010565 50 0.062
negative regulation of response to dna damage stimulus GO:2001021 33 0.062
regulation of cytoskeleton organization GO:0051493 177 0.061
guanosine containing compound metabolic process GO:1901068 244 0.060
male gonad development GO:0008584 23 0.060
cell development GO:0048468 328 0.060
Fly
cellular ketone metabolic process GO:0042180 80 0.059
peptidyl serine modification GO:0018209 106 0.059
regulation of locomotion GO:0040012 329 0.059
negative regulation of protein phosphorylation GO:0001933 140 0.059
amine metabolic process GO:0009308 44 0.057
regulation of intracellular protein transport GO:0033157 123 0.057
cytokine mediated signaling pathway GO:0019221 109 0.056
lipid metabolic process GO:0006629 381 0.055
cellular amino acid metabolic process GO:0006520 116 0.055
cellular response to organic cyclic compound GO:0071407 127 0.055
negative regulation of programmed cell death GO:0043069 321 0.055
reciprocal dna recombination GO:0035825 4 0.054
regulation of microtubule cytoskeleton organization GO:0070507 61 0.053
protein polyubiquitination GO:0000209 110 0.053
development of primary sexual characteristics GO:0045137 35 0.053
negative regulation of apoptotic process GO:0043066 316 0.052
regulation of histone acetylation GO:0035065 19 0.052
mitotic sister chromatid segregation GO:0000070 53 0.052
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.052
signal transduction in absence of ligand GO:0038034 22 0.051
positive regulation of nucleotide metabolic process GO:0045981 230 0.051
cellular response to hypoxia GO:0071456 51 0.051
positive regulation of protein phosphorylation GO:0001934 313 0.051
nucleotide catabolic process GO:0009166 408 0.051
positive regulation of response to dna damage stimulus GO:2001022 43 0.051
urogenital system development GO:0001655 65 0.050
regulation of double strand break repair via homologous recombination GO:0010569 11 0.049
positive regulation of apoptotic signaling pathway GO:2001235 70 0.049
positive regulation of cell division GO:0051781 59 0.049
negative regulation of protein modification process GO:0031400 200 0.049
limbic system development GO:0021761 3 0.048
maintenance of location GO:0051235 112 0.048
resolution of meiotic recombination intermediates GO:0000712 3 0.048
response to decreased oxygen levels GO:0036293 96 0.048
dephosphorylation GO:0016311 209 0.048
cytoplasmic transport GO:0016482 379 0.048
reproductive structure development GO:0048608 55 0.048
regulation of cytoplasmic transport GO:1903649 149 0.047
reproductive system development GO:0061458 56 0.047
response to drug GO:0042493 81 0.047
protein localization to organelle GO:0033365 280 0.046
response to uv GO:0009411 73 0.046
purine nucleoside catabolic process GO:0006152 398 0.046
regulation of secretion by cell GO:1903530 177 0.046
regulation of endopeptidase activity GO:0052548 170 0.045
Fly
developmental process involved in reproduction GO:0003006 66 0.045
Fly
cellular response to lipid GO:0071396 127 0.044
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.044
negative regulation of organelle organization GO:0010639 126 0.043
cellular component disassembly GO:0022411 92 0.043
rhythmic process GO:0048511 31 0.043
nucleoside triphosphate metabolic process GO:0009141 422 0.043
regulation of anatomical structure morphogenesis GO:0022603 286 0.042
negative regulation of lipid metabolic process GO:0045833 38 0.042
immune response activating signal transduction GO:0002757 90 0.042
embryo development ending in birth or egg hatching GO:0009792 34 0.041
Worm
regulation of cellular protein catabolic process GO:1903362 96 0.041
g2 m transition of mitotic cell cycle GO:0000086 41 0.041
positive regulation of cellular component organization GO:0051130 376 0.040
positive regulation of cytoskeleton organization GO:0051495 83 0.039
regulation of mitotic metaphase anaphase transition GO:0030071 26 0.039
nucleoside triphosphate catabolic process GO:0009143 394 0.039
protein import into nucleus GO:0006606 104 0.039
interleukin 1 production GO:0032612 26 0.039
morphogenesis of a branching structure GO:0001763 21 0.038
cellular cation homeostasis GO:0030003 163 0.038
dna catabolic process endonucleolytic GO:0000737 37 0.038
response to light stimulus GO:0009416 87 0.038
angiogenesis GO:0001525 147 0.038
regulation of centrosome duplication GO:0010824 14 0.038
regulation of protein kinase activity GO:0045859 289 0.037
negative regulation of peptidase activity GO:0010466 91 0.037
cellular metal ion homeostasis GO:0006875 146 0.037
response to toxic substance GO:0009636 37 0.036
apoptotic process involved in morphogenesis GO:0060561 3 0.036
protein maturation GO:0051604 233 0.036
Fly
cellular ion homeostasis GO:0006873 168 0.036
positive regulation of ras gtpase activity GO:0032320 117 0.036
microtubule nucleation GO:0007020 6 0.036
activation of cysteine type endopeptidase activity GO:0097202 57 0.036
Fly
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.036
positive regulation of transport GO:0051050 336 0.035
positive regulation of transferase activity GO:0051347 227 0.035
regulation of actin cytoskeleton organization GO:0032956 116 0.035
regulation of peptidase activity GO:0052547 180 0.035
Fly
neuromuscular junction development GO:0007528 3 0.034
positive regulation of cell morphogenesis involved in differentiation GO:0010770 50 0.034
positive regulation of dendrite morphogenesis GO:0050775 3 0.034
purine nucleoside monophosphate metabolic process GO:0009126 186 0.034
nucleoside phosphate catabolic process GO:1901292 412 0.033
circadian rhythm GO:0007623 21 0.033
response to reactive oxygen species GO:0000302 61 0.033
triglyceride homeostasis GO:0070328 14 0.033
golgi inheritance GO:0048313 2 0.033
single organism reproductive process GO:0044702 98 0.032
Fly
microtubule organizing center organization GO:0031023 62 0.032
circulatory system development GO:0072359 262 0.032
regulation of establishment of protein localization GO:0070201 242 0.032
negative regulation of mitosis GO:0045839 24 0.031
cell adhesion GO:0007155 325 0.031
neutrophil aggregation GO:0070488 2 0.031
response to oxygen levels GO:0070482 100 0.031
ribonucleoside triphosphate metabolic process GO:0009199 412 0.031
regulation of leukocyte proliferation GO:0070663 67 0.031
regulation of defense response GO:0031347 154 0.030
positive regulation of cellular protein catabolic process GO:1903364 37 0.030
circadian behavior GO:0048512 2 0.030
response to transition metal nanoparticle GO:1990267 29 0.030
ribonucleotide catabolic process GO:0009261 405 0.030
base excision repair GO:0006284 21 0.030
cell morphogenesis involved in differentiation GO:0000904 144 0.029
histone acetylation GO:0016573 93 0.029
protein heterotetramerization GO:0051290 3 0.029
reciprocal meiotic recombination GO:0007131 4 0.029
central nervous system development GO:0007417 123 0.029
rho protein signal transduction GO:0007266 26 0.028
regulation of cellular amino acid metabolic process GO:0006521 6 0.028
reproduction GO:0000003 63 0.028
Worm Fly
organelle assembly GO:0070925 176 0.028
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.028
centrosome duplication GO:0051298 28 0.028
cell cell signaling GO:0007267 155 0.028
protein oligomerization GO:0051259 173 0.028
oogenesis GO:0048477 2 0.028
response to alkaloid GO:0043279 20 0.028
positive regulation of dna repair GO:0045739 25 0.028
brain development GO:0007420 97 0.028
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.027
positive regulation of fibroblast proliferation GO:0048146 21 0.027
cell part morphogenesis GO:0032990 137 0.027
positive regulation of protein kinase activity GO:0045860 190 0.027
gtp metabolic process GO:0046039 239 0.027
negative regulation of cell division GO:0051782 31 0.027
response to fungus GO:0009620 4 0.026
negative regulation of lipid kinase activity GO:0090219 3 0.026
histone h3 k9 modification GO:0061647 11 0.026
positive regulation of cellular catabolic process GO:0031331 284 0.026
response to lipid GO:0033993 206 0.026
regulation of mononuclear cell proliferation GO:0032944 65 0.026
histone serine phosphorylation GO:0035404 4 0.026
protein targeting to nucleus GO:0044744 104 0.026
golgi organization GO:0007030 38 0.025
gonad development GO:0008406 34 0.025
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.025
regulation of circadian rhythm GO:0042752 11 0.025
glycosyl compound catabolic process GO:1901658 413 0.025
cellular response to iron ion GO:0071281 1 0.025
pattern specification process GO:0007389 43 0.025
hippocampus development GO:0021766 1 0.025
regulation of protein catabolic process GO:0042176 155 0.025
mammary gland development GO:0030879 17 0.025
cellular response to endogenous stimulus GO:0071495 336 0.025
centrosome organization GO:0051297 58 0.025
regulation of nucleocytoplasmic transport GO:0046822 98 0.024
regulation of protein dephosphorylation GO:0035304 18 0.024
divalent inorganic cation homeostasis GO:0072507 136 0.024
regulation of dna damage response signal transduction by p53 class mediator GO:0043516 20 0.024
lens development in camera type eye GO:0002088 2 0.024
glycogen biosynthetic process GO:0005978 16 0.024
negative regulation of glycoprotein metabolic process GO:1903019 8 0.024
anatomical structure homeostasis GO:0060249 100 0.024
adherens junction organization GO:0034332 36 0.023
glycerolipid metabolic process GO:0046486 107 0.023
protein deubiquitination GO:0016579 79 0.023
protein destabilization GO:0031648 12 0.023
branching morphogenesis of an epithelial tube GO:0048754 19 0.023
negative regulation of protein serine threonine kinase activity GO:0071901 57 0.023
mitotic nuclear division GO:0007067 119 0.023
purine nucleoside triphosphate metabolic process GO:0009144 412 0.022
positive regulation of cytokinesis GO:0032467 29 0.022
purine ribonucleotide catabolic process GO:0009154 404 0.022
cell morphogenesis GO:0000902 296 0.022
gtp catabolic process GO:0006184 237 0.022
regulation of cellular component size GO:0032535 82 0.022
cellular response to abiotic stimulus GO:0071214 117 0.022
Fly
regulation of viral process GO:0050792 103 0.022
oocyte development GO:0048599 1 0.022
actin filament bundle assembly GO:0051017 54 0.022
regulation of protein targeting GO:1903533 91 0.022
intracellular protein transport GO:0006886 270 0.022
centrosome cycle GO:0007098 32 0.022
protein targeting GO:0006605 187 0.022
negative regulation of g2 m transition of mitotic cell cycle GO:0010972 9 0.022
regulation of protein transport GO:0051223 213 0.021
regulation of transcription by chromatin organization GO:0034401 1 0.021
meiotic nuclear division GO:0007126 10 0.021
Worm
transcription factor import into nucleus GO:0042991 40 0.021
carbohydrate metabolic process GO:0005975 207 0.021
peptidyl tyrosine dephosphorylation GO:0035335 36 0.021
oxidation reduction process GO:0055114 396 0.021
regulation of cell substrate adhesion GO:0010810 68 0.021
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.021
interleukin 1 alpha secretion GO:0050703 1 0.021
positive regulation of programmed cell death GO:0043068 249 0.021
Fly
nucleus organization GO:0006997 28 0.020
response to steroid hormone GO:0048545 80 0.020
regulation of cellular ketone metabolic process by positive regulation of transcription from rna polymerase ii promoter GO:0072366 1 0.020
endocytosis GO:0006897 159 0.020
purine nucleoside monophosphate catabolic process GO:0009128 158 0.020
defense response to fungus GO:0050832 4 0.020
positive regulation of catabolic process GO:0009896 310 0.020
cell cycle g2 m phase transition GO:0044839 43 0.020
regulation of nervous system development GO:0051960 88 0.020
chromosome separation GO:0051304 23 0.020
positive regulation of dna damage response signal transduction by p53 class mediator GO:0043517 8 0.020
response to tumor necrosis factor GO:0034612 76 0.020
positive regulation of multi organism process GO:0043902 56 0.020
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.020
regulation of protein import into nucleus GO:0042306 78 0.020
negative regulation of cell cycle g2 m phase transition GO:1902750 10 0.020
anterior posterior axis specification GO:0009948 2 0.020
cellular divalent inorganic cation homeostasis GO:0072503 128 0.019
negative regulation of protein ubiquitination GO:0031397 35 0.019
response to oxygen containing compound GO:1901700 369 0.019
chromatin mediated maintenance of transcription GO:0048096 2 0.019
locomotory behavior GO:0007626 1 0.019
tube development GO:0035295 125 0.019
centriole replication GO:0007099 13 0.019
hexose metabolic process GO:0019318 55 0.019
regulation of neuron projection development GO:0010975 57 0.019
apoptotic mitochondrial changes GO:0008637 57 0.019
single organismal cell cell adhesion GO:0016337 148 0.019
negative regulation of protein processing GO:0010955 142 0.019
positive regulation of cell death GO:0010942 263 0.019
Fly
cardiac chamber development GO:0003205 30 0.019
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.019
Fly
negative regulation of protein kinase activity GO:0006469 98 0.018
positive regulation of mitotic cell cycle GO:0045931 60 0.018
cation transport GO:0006812 331 0.018
cell growth GO:0016049 160 0.018
renal system development GO:0072001 63 0.018
negative regulation of neural precursor cell proliferation GO:2000178 1 0.018
regulation of neuron differentiation GO:0045664 70 0.018

CHEK2 disease predictions

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 167 0.907
disease of cellular proliferation DOID:14566 174 0.907
organ system cancer DOID:0050686 164 0.672
immune system disease DOID:2914 155 0.386
aplastic anemia DOID:12449 30 0.200
bone marrow disease DOID:4961 31 0.200
anemia DOID:2355 55 0.200
hematopoietic system disease DOID:74 100 0.200
breast cancer DOID:1612 21 0.143
thoracic cancer DOID:5093 21 0.143
congenital hypoplastic anemia DOID:1342 26 0.100
gastrointestinal system cancer DOID:3119 52 0.042
large intestine cancer DOID:5672 29 0.025
colon cancer DOID:219 25 0.025
intestinal cancer DOID:10155 29 0.025
colorectal cancer DOID:9256 29 0.025
hepatocellular carcinoma DOID:684 9 0.022
liver carcinoma DOID:686 9 0.022
liver cancer DOID:3571 9 0.022