|
|
amide biosynthetic process
|
GO:0043604 |
15 |
0.989
|
Fly |
|
|
regulation of i kappab kinase nf kappab signaling
|
GO:0043122 |
162 |
0.987
|
Human Zebrafish Mouse |
|
|
positive regulation of i kappab kinase nf kappab signaling
|
GO:0043123 |
132 |
0.981
|
Human Mouse |
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
379 |
0.970
|
Human |
|
|
i kappab kinase nf kappab signaling
|
GO:0007249 |
166 |
0.961
|
Human Zebrafish Mouse |
|
|
lipid metabolic process
|
GO:0006629 |
381 |
0.952
|
|
|
|
regulation of stress activated mapk cascade
|
GO:0032872 |
84 |
0.931
|
|
|
|
regulation of mapk cascade
|
GO:0043408 |
262 |
0.912
|
|
|
|
positive regulation of humoral immune response
|
GO:0002922 |
3 |
0.909
|
Fly |
|
|
regulation of cytokine production
|
GO:0001817 |
232 |
0.909
|
Human |
|
|
serine phosphorylation of stat protein
|
GO:0042501 |
4 |
0.905
|
Human |
|
|
single organism cellular localization
|
GO:1902580 |
332 |
0.899
|
|
|
|
protein autophosphorylation
|
GO:0046777 |
123 |
0.874
|
|
|
|
organonitrogen compound biosynthetic process
|
GO:1901566 |
200 |
0.861
|
Fly |
|
|
positive regulation of antimicrobial humoral response
|
GO:0002760 |
1 |
0.851
|
Fly |
|
|
innate immune response
|
GO:0045087 |
178 |
0.835
|
Fly |
|
|
regulation of defense response to bacterium
|
GO:1900424 |
2 |
0.819
|
Fly |
|
|
intracellular protein transport
|
GO:0006886 |
270 |
0.795
|
|
|
|
response to cytokine
|
GO:0034097 |
232 |
0.789
|
|
|
|
protein import
|
GO:0017038 |
130 |
0.788
|
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
249 |
0.763
|
|
|
|
response to virus
|
GO:0009615 |
126 |
0.751
|
Fly |
|
|
defense response to bacterium
|
GO:0042742 |
63 |
0.721
|
Fly |
|
|
negative regulation of programmed cell death
|
GO:0043069 |
321 |
0.711
|
Zebrafish |
|
|
response to bacterium
|
GO:0009617 |
144 |
0.709
|
Fly |
|
|
response to uv
|
GO:0009411 |
73 |
0.707
|
|
|
|
mitotic cell cycle
|
GO:0000278 |
326 |
0.690
|
|
|
|
response to abiotic stimulus
|
GO:0009628 |
336 |
0.686
|
|
|
|
regulation of cell cycle
|
GO:0051726 |
393 |
0.683
|
|
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
211 |
0.670
|
Human |
|
|
vesicle mediated transport
|
GO:0016192 |
371 |
0.639
|
|
|
|
regulation of defense response
|
GO:0031347 |
154 |
0.639
|
Fly |
|
|
positive regulation of production of molecular mediator of immune response
|
GO:0002702 |
11 |
0.627
|
Fly |
|
|
cation transport
|
GO:0006812 |
331 |
0.625
|
|
|
|
response to other organism
|
GO:0051707 |
261 |
0.618
|
Fly |
|
|
peptidyl serine modification
|
GO:0018209 |
106 |
0.613
|
Human Fly |
|
|
tube development
|
GO:0035295 |
125 |
0.611
|
Zebrafish |
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
391 |
0.605
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
289 |
0.578
|
|
|
|
regulation of antimicrobial humoral response
|
GO:0002759 |
1 |
0.574
|
Fly |
|
|
regulation of multi organism process
|
GO:0043900 |
157 |
0.569
|
Fly |
|
|
defense response to virus
|
GO:0051607 |
71 |
0.560
|
Fly |
|
|
peptidyl serine phosphorylation
|
GO:0018105 |
101 |
0.552
|
Human Fly |
|
|
negative regulation of phosphorylation
|
GO:0042326 |
174 |
0.537
|
|
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
313 |
0.532
|
|
|
|
defense response to other organism
|
GO:0098542 |
129 |
0.530
|
Fly |
|
|
response to radiation
|
GO:0009314 |
151 |
0.522
|
|
|
|
response to lipid
|
GO:0033993 |
206 |
0.513
|
|
|
|
nervous system development
|
GO:0007399 |
293 |
0.508
|
Zebrafish |
|
|
lipid biosynthetic process
|
GO:0008610 |
177 |
0.495
|
|
|
|
regulation of intracellular protein transport
|
GO:0033157 |
123 |
0.494
|
|
|
|
actin filament based process
|
GO:0030029 |
224 |
0.494
|
|
|
|
peptide metabolic process
|
GO:0006518 |
51 |
0.493
|
Fly |
|
|
protein complex localization
|
GO:0031503 |
31 |
0.489
|
|
|
|
regulation of response to external stimulus
|
GO:0032101 |
222 |
0.467
|
Fly |
|
|
regulation of cellular response to stress
|
GO:0080135 |
244 |
0.463
|
|
|
|
protein targeting
|
GO:0006605 |
187 |
0.461
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.447
|
|
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.432
|
|
|
|
cellular macromolecular complex assembly
|
GO:0034622 |
324 |
0.420
|
|
|
|
organic hydroxy compound metabolic process
|
GO:1901615 |
147 |
0.419
|
|
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
140 |
0.414
|
|
|
|
amide transport
|
GO:0042886 |
76 |
0.411
|
|
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
127 |
0.401
|
Human |
|
|
intrinsic apoptotic signaling pathway in response to dna damage
|
GO:0008630 |
50 |
0.400
|
Human |
|
|
negative regulation of transport
|
GO:0051051 |
176 |
0.394
|
|
|
|
mitotic cell cycle process
|
GO:1903047 |
286 |
0.390
|
|
|
|
cellular response to oxygen containing compound
|
GO:1901701 |
276 |
0.381
|
|
|
|
organic hydroxy compound transport
|
GO:0015850 |
63 |
0.379
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
179 |
0.377
|
|
|
|
cytokine production
|
GO:0001816 |
247 |
0.374
|
Human |
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
183 |
0.371
|
Zebrafish |
|
|
peptide transport
|
GO:0015833 |
74 |
0.360
|
|
|
|
metal ion transport
|
GO:0030001 |
272 |
0.356
|
|
|
|
apoptotic signaling pathway
|
GO:0097190 |
268 |
0.353
|
Human |
|
|
erk1 and erk2 cascade
|
GO:0070371 |
104 |
0.345
|
|
|
|
cytoplasmic transport
|
GO:0016482 |
379 |
0.337
|
|
|
|
negative regulation of stress activated mapk cascade
|
GO:0032873 |
19 |
0.334
|
|
|
|
response to light stimulus
|
GO:0009416 |
87 |
0.332
|
|
|
|
protein localization to organelle
|
GO:0033365 |
280 |
0.326
|
|
|
|
response to external biotic stimulus
|
GO:0043207 |
261 |
0.326
|
Fly |
|
|
regulation of jnk cascade
|
GO:0046328 |
73 |
0.325
|
|
|
|
multicellular organismal aging
|
GO:0010259 |
3 |
0.325
|
|
|
|
regulation of map kinase activity
|
GO:0043405 |
108 |
0.322
|
|
|
|
jnk cascade
|
GO:0007254 |
80 |
0.320
|
|
|
|
post embryonic development
|
GO:0009791 |
2 |
0.320
|
|
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.316
|
|
|
|
response to biotic stimulus
|
GO:0009607 |
276 |
0.310
|
Fly |
|
|
regulation of meiotic cell cycle
|
GO:0051445 |
4 |
0.308
|
|
|
|
skeletal muscle contraction
|
GO:0003009 |
16 |
0.306
|
|
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
190 |
0.305
|
|
|
|
nuclear transport
|
GO:0051169 |
179 |
0.297
|
|
|
|
ion transmembrane transport
|
GO:0034220 |
338 |
0.297
|
|
|
|
negative regulation of mapk cascade
|
GO:0043409 |
56 |
0.290
|
|
|
|
negative regulation of protein serine threonine kinase activity
|
GO:0071901 |
57 |
0.288
|
|
|
|
antimicrobial humoral response
|
GO:0019730 |
26 |
0.287
|
Fly |
|
|
mitotic cell cycle phase transition
|
GO:0044772 |
162 |
0.286
|
|
|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.284
|
|
|
|
regulation of cellular component biogenesis
|
GO:0044087 |
281 |
0.277
|
|
|
|
negative regulation of jnk cascade
|
GO:0046329 |
16 |
0.275
|
|
|
|
cellular response to lipid
|
GO:0071396 |
127 |
0.267
|
|
|
|
mapk cascade
|
GO:0000165 |
288 |
0.266
|
|
|
|
positive regulation of sequence specific dna binding transcription factor activity
|
GO:0051091 |
131 |
0.263
|
Human |
|
|
regulation of stress activated protein kinase signaling cascade
|
GO:0070302 |
85 |
0.260
|
|
|
|
tube morphogenesis
|
GO:0035239 |
95 |
0.256
|
Zebrafish |
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.254
|
|
|
|
organelle fission
|
GO:0048285 |
149 |
0.249
|
|
|
|
cholesterol transport
|
GO:0030301 |
39 |
0.243
|
|
|
|
nik nf kappab signaling
|
GO:0038061 |
12 |
0.240
|
Human |
|
|
regulation of erk1 and erk2 cascade
|
GO:0070372 |
99 |
0.240
|
|
|
|
reactive oxygen species metabolic process
|
GO:0072593 |
75 |
0.239
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
11 |
0.237
|
|
|
|
regulation of defense response to virus
|
GO:0050688 |
33 |
0.235
|
Fly |
|
|
cellular response to molecule of bacterial origin
|
GO:0071219 |
62 |
0.234
|
|
|
|
cell cycle phase transition
|
GO:0044770 |
173 |
0.234
|
|
|
|
protein catabolic process
|
GO:0030163 |
325 |
0.233
|
Fly |
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
267 |
0.230
|
|
|
|
signal transduction by phosphorylation
|
GO:0023014 |
297 |
0.230
|
Human |
|
|
negative regulation of protein import into nucleus
|
GO:0042308 |
30 |
0.227
|
|
|
|
production of molecular mediator of immune response
|
GO:0002440 |
37 |
0.226
|
Fly |
|
|
regulation of type i interferon production
|
GO:0032479 |
26 |
0.224
|
Human |
|
|
oogenesis
|
GO:0048477 |
2 |
0.223
|
|
|
|
regulation of immune effector process
|
GO:0002697 |
91 |
0.222
|
Fly |
|
|
regulation of ion transport
|
GO:0043269 |
189 |
0.221
|
|
|
|
covalent chromatin modification
|
GO:0016569 |
254 |
0.221
|
|
|
|
positive regulation of cell death
|
GO:0010942 |
263 |
0.221
|
|
|
|
activation of jnkk activity
|
GO:0007256 |
1 |
0.218
|
|
|
|
positive regulation of defense response
|
GO:0031349 |
87 |
0.216
|
Fly |
|
|
sterol transport
|
GO:0015918 |
39 |
0.213
|
|
|
|
monovalent inorganic cation transport
|
GO:0015672 |
128 |
0.211
|
|
|
|
negative regulation of protein transport
|
GO:0051224 |
75 |
0.210
|
|
|
|
anatomical structure formation involved in morphogenesis
|
GO:0048646 |
284 |
0.207
|
Zebrafish |
|
|
cellular lipid metabolic process
|
GO:0044255 |
303 |
0.204
|
|
|
|
cytokine mediated signaling pathway
|
GO:0019221 |
109 |
0.204
|
|
|
|
negative regulation of multicellular organismal process
|
GO:0051241 |
317 |
0.202
|
|
|
|
enzyme linked receptor protein signaling pathway
|
GO:0007167 |
303 |
0.198
|
|
|
|
dephosphorylation
|
GO:0016311 |
209 |
0.194
|
|
|
|
embryo development
|
GO:0009790 |
123 |
0.192
|
Zebrafish |
|
|
negative regulation of cell cycle phase transition
|
GO:1901988 |
89 |
0.192
|
|
|
|
positive regulation of response to external stimulus
|
GO:0032103 |
88 |
0.191
|
Fly |
|
|
positive regulation of cholesterol efflux
|
GO:0010875 |
8 |
0.187
|
|
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
244 |
0.187
|
|
|
|
positive regulation of mapk cascade
|
GO:0043410 |
190 |
0.185
|
|
|
|
intracellular receptor signaling pathway
|
GO:0030522 |
104 |
0.185
|
|
|
|
regulation of cell cycle process
|
GO:0010564 |
266 |
0.185
|
|
|
|
regulation of interferon beta production
|
GO:0032648 |
22 |
0.184
|
Human |
|
|
response to oxygen containing compound
|
GO:1901700 |
369 |
0.183
|
|
|
|
humoral immune response
|
GO:0006959 |
49 |
0.183
|
Fly |
|
|
type i interferon production
|
GO:0032606 |
27 |
0.181
|
Human |
|
|
multicellular organismal movement
|
GO:0050879 |
17 |
0.181
|
|
|
|
protein dephosphorylation
|
GO:0006470 |
81 |
0.179
|
|
|
|
protein localization to nucleus
|
GO:0034504 |
136 |
0.174
|
|
|
|
negative regulation of immune system process
|
GO:0002683 |
136 |
0.170
|
|
|
|
negative regulation of stress activated protein kinase signaling cascade
|
GO:0070303 |
19 |
0.168
|
|
|
|
regulation of protein localization to nucleus
|
GO:1900180 |
85 |
0.163
|
|
|
|
regulation of lipid transport
|
GO:0032368 |
44 |
0.158
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
41 |
0.158
|
|
|
|
positive regulation of protein serine threonine kinase activity
|
GO:0071902 |
119 |
0.155
|
|
|
|
cellular component morphogenesis
|
GO:0032989 |
314 |
0.152
|
|
|
|
i kappab phosphorylation
|
GO:0007252 |
7 |
0.149
|
|
|
|
positive regulation of multi organism process
|
GO:0043902 |
56 |
0.146
|
Fly |
|
|
lipid transport
|
GO:0006869 |
90 |
0.146
|
|
|
|
cell development
|
GO:0048468 |
328 |
0.146
|
|
|
|
stress activated protein kinase signaling cascade
|
GO:0031098 |
94 |
0.140
|
|
|
|
regulation of establishment of protein localization
|
GO:0070201 |
242 |
0.139
|
|
|
|
cellular response to mechanical stimulus
|
GO:0071260 |
39 |
0.138
|
|
|
|
negative regulation of lipid storage
|
GO:0010888 |
11 |
0.138
|
|
|
|
negative regulation of cytoplasmic transport
|
GO:1903650 |
46 |
0.137
|
|
|
|
musculoskeletal movement
|
GO:0050881 |
17 |
0.135
|
|
|
|
maintenance of location in cell
|
GO:0051651 |
62 |
0.134
|
|
|
|
nuclear import
|
GO:0051170 |
106 |
0.133
|
|
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.133
|
|
|
|
determination of adult lifespan
|
GO:0008340 |
2 |
0.129
|
|
|
|
mitotic sister chromatid segregation
|
GO:0000070 |
53 |
0.128
|
|
|
|
regulation of nucleocytoplasmic transport
|
GO:0046822 |
98 |
0.128
|
|
|
|
phospholipid metabolic process
|
GO:0006644 |
99 |
0.127
|
|
|
|
cellular protein complex assembly
|
GO:0043623 |
188 |
0.126
|
|
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
175 |
0.126
|
|
|
|
regulation of mitotic cell cycle phase transition
|
GO:1901990 |
118 |
0.125
|
|
|
|
negative regulation of mitotic cell cycle phase transition
|
GO:1901991 |
85 |
0.125
|
|
|
|
modification dependent macromolecule catabolic process
|
GO:0043632 |
212 |
0.123
|
|
|
|
regulation of immune response
|
GO:0050776 |
201 |
0.121
|
Fly |
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
267 |
0.121
|
|
|
|
regulation of translation
|
GO:0006417 |
89 |
0.121
|
|
|
|
regulation of dna metabolic process
|
GO:0051052 |
153 |
0.119
|
|
|
|
positive regulation of immune response
|
GO:0050778 |
159 |
0.118
|
Fly |
|
|
digestive system development
|
GO:0055123 |
75 |
0.118
|
Zebrafish |
|
|
positive regulation of immune system process
|
GO:0002684 |
283 |
0.118
|
Fly |
|
|
positive regulation of transferase activity
|
GO:0051347 |
227 |
0.117
|
|
|
|
nitrogen compound transport
|
GO:0071705 |
191 |
0.115
|
|
|
|
carbohydrate metabolic process
|
GO:0005975 |
207 |
0.115
|
|
|
|
negative regulation of kinase activity
|
GO:0033673 |
106 |
0.113
|
|
|
|
regulation of metal ion transport
|
GO:0010959 |
120 |
0.113
|
|
|
|
negative regulation of protein localization to nucleus
|
GO:1900181 |
34 |
0.112
|
|
|
|
positive regulation of defense response to bacterium
|
GO:1900426 |
1 |
0.112
|
Fly |
|
|
modification dependent protein catabolic process
|
GO:0019941 |
209 |
0.110
|
|
|
|
negative regulation of intracellular protein transport
|
GO:0090317 |
42 |
0.109
|
|
|
|
actin cytoskeleton organization
|
GO:0030036 |
207 |
0.108
|
|
|
|
single organism membrane organization
|
GO:0044802 |
268 |
0.107
|
|
|
|
microtubule based process
|
GO:0007017 |
210 |
0.107
|
|
|
|
regulation of ion transmembrane transporter activity
|
GO:0032412 |
72 |
0.102
|
|
|
|
regulation of cell cycle phase transition
|
GO:1901987 |
126 |
0.101
|
|
|
|
positive regulation of nf kappab transcription factor activity
|
GO:0051092 |
81 |
0.099
|
Human |
|
|
cytokinesis
|
GO:0000910 |
96 |
0.099
|
|
|
|
protein localization to membrane
|
GO:0072657 |
160 |
0.097
|
|
|
|
negative regulation of transferase activity
|
GO:0051348 |
124 |
0.096
|
|
|
|
defense response
|
GO:0006952 |
315 |
0.096
|
Fly |
|
|
n terminal protein amino acid modification
|
GO:0031365 |
13 |
0.096
|
|
|
|
regulation of lipid metabolic process
|
GO:0019216 |
96 |
0.096
|
|
|
|
intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator
|
GO:0042771 |
23 |
0.094
|
|
|
|
regulation of transcription factor import into nucleus
|
GO:0042990 |
39 |
0.094
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.094
|
|
|
|
antibacterial humoral response
|
GO:0019731 |
24 |
0.094
|
Fly |
|
|
regulation of autophagy
|
GO:0010506 |
52 |
0.093
|
|
|
|
negative regulation of protein kinase activity
|
GO:0006469 |
98 |
0.093
|
|
|
|
female gamete generation
|
GO:0007292 |
2 |
0.092
|
|
|
|
negative regulation of nucleocytoplasmic transport
|
GO:0046823 |
37 |
0.090
|
|
|
|
morphogenesis of embryonic epithelium
|
GO:0016331 |
4 |
0.090
|
|
|
|
negative regulation of protein modification process
|
GO:0031400 |
200 |
0.090
|
|
|
|
stress activated mapk cascade
|
GO:0051403 |
93 |
0.089
|
|
|
|
ras protein signal transduction
|
GO:0007265 |
73 |
0.088
|
|
|
|
lymphocyte homeostasis
|
GO:0002260 |
4 |
0.087
|
|
|
|
maintenance of protein location in cell
|
GO:0032507 |
56 |
0.085
|
|
|
|
immune response
|
GO:0006955 |
307 |
0.085
|
Fly |
|
|
alcohol metabolic process
|
GO:0006066 |
114 |
0.084
|
|
|
|
positive regulation of transporter activity
|
GO:0032411 |
32 |
0.084
|
|
|
|
negative regulation of cellular component organization
|
GO:0051129 |
235 |
0.084
|
|
|
|
dna repair
|
GO:0006281 |
198 |
0.084
|
|
|
|
angiogenesis
|
GO:0001525 |
147 |
0.083
|
|
|
|
glycerophospholipid metabolic process
|
GO:0006650 |
84 |
0.082
|
|
|
|
protein folding
|
GO:0006457 |
38 |
0.082
|
|
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
380 |
0.081
|
|
|
|
cellular protein catabolic process
|
GO:0044257 |
261 |
0.081
|
|
|
|
signal transduction in response to dna damage
|
GO:0042770 |
57 |
0.081
|
|
|
|
purine nucleoside monophosphate catabolic process
|
GO:0009128 |
158 |
0.078
|
|
|
|
positive regulation of cell development
|
GO:0010720 |
92 |
0.078
|
|
|
|
positive regulation of defense response to virus by host
|
GO:0002230 |
14 |
0.078
|
Fly |
|
|
glycerolipid metabolic process
|
GO:0046486 |
107 |
0.078
|
|
|
|
activation of protein kinase activity
|
GO:0032147 |
90 |
0.076
|
|
|
|
mitochondrion organization
|
GO:0007005 |
156 |
0.076
|
|
|
|
neural tube formation
|
GO:0001841 |
3 |
0.075
|
|
|
|
wnt signaling pathway
|
GO:0016055 |
156 |
0.074
|
|
|
|
histone modification
|
GO:0016570 |
251 |
0.074
|
|
|
|
regulation of secretion
|
GO:0051046 |
194 |
0.074
|
|
|
|
regulation of jak stat cascade
|
GO:0046425 |
44 |
0.073
|
Human |
|
|
regulation of nf kappab import into nucleus
|
GO:0042345 |
22 |
0.073
|
|
|
|
positive regulation of transport
|
GO:0051050 |
336 |
0.073
|
|
|
|
negative regulation of transcription factor import into nucleus
|
GO:0042992 |
17 |
0.072
|
|
|
|
cellular amide metabolic process
|
GO:0043603 |
69 |
0.071
|
Fly |
|
|
maintenance of protein location
|
GO:0045185 |
57 |
0.071
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
6 |
0.071
|
|
|
|
transmembrane transport
|
GO:0055085 |
399 |
0.070
|
|
|
|
digestive tract morphogenesis
|
GO:0048546 |
56 |
0.070
|
Zebrafish |
|
|
negative regulation of map kinase activity
|
GO:0043407 |
27 |
0.070
|
|
|
|
sodium ion transport
|
GO:0006814 |
61 |
0.069
|
|
|
|
g1 s transition of mitotic cell cycle
|
GO:0000082 |
78 |
0.067
|
|
|
|
negative regulation of catabolic process
|
GO:0009895 |
104 |
0.067
|
|
|
|
system process
|
GO:0003008 |
349 |
0.067
|
|
|
|
regulation of protein import into nucleus
|
GO:0042306 |
78 |
0.066
|
|
|
|
negative regulation of lipid metabolic process
|
GO:0045833 |
38 |
0.066
|
|
|
|
striated muscle contraction
|
GO:0006941 |
52 |
0.066
|
|
|
|
cell morphogenesis
|
GO:0000902 |
296 |
0.066
|
|
|
|
regulation of innate immune response
|
GO:0045088 |
97 |
0.063
|
Fly |
|
|
positive regulation of cell proliferation
|
GO:0008284 |
301 |
0.063
|
|
|
|
negative regulation of mitotic cell cycle
|
GO:0045930 |
102 |
0.062
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
204 |
0.062
|
|
|
|
cell aging
|
GO:0007569 |
52 |
0.060
|
|
|
|
regulation of cytokine biosynthetic process
|
GO:0042035 |
35 |
0.060
|
|
|
|
regulation of transporter activity
|
GO:0032409 |
82 |
0.060
|
|
|
|
positive regulation of response to biotic stimulus
|
GO:0002833 |
18 |
0.059
|
Fly |
|
|
positive regulation of innate immune response
|
GO:0045089 |
79 |
0.059
|
|
|
|
dna integrity checkpoint
|
GO:0031570 |
71 |
0.059
|
|
|
|
translation
|
GO:0006412 |
132 |
0.059
|
|
|
|
ribonucleoside monophosphate metabolic process
|
GO:0009161 |
187 |
0.058
|
|
|
|
reproductive process
|
GO:0022414 |
106 |
0.058
|
|
|
|
nucleotide binding oligomerization domain containing signaling pathway
|
GO:0070423 |
4 |
0.058
|
|
|
|
glycoprotein metabolic process
|
GO:0009100 |
110 |
0.057
|
|
|
|
single organism nuclear import
|
GO:1902593 |
104 |
0.057
|
|
|
|
protein import into nucleus translocation
|
GO:0000060 |
22 |
0.057
|
|
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.056
|
|
|
|
response to hormone
|
GO:0009725 |
175 |
0.056
|
|
|
|
cellular response to nitrogen compound
|
GO:1901699 |
144 |
0.055
|
|
|
|
regulation of cytoskeleton organization
|
GO:0051493 |
177 |
0.055
|
|
|
|
cardiovascular system development
|
GO:0072358 |
262 |
0.054
|
|
|
|
digestive tract development
|
GO:0048565 |
75 |
0.053
|
Zebrafish |
|
|
regulation of lipid biosynthetic process
|
GO:0046890 |
47 |
0.053
|
|
|
|
establishment of protein localization to organelle
|
GO:0072594 |
172 |
0.052
|
|
|
|
regulation of response to biotic stimulus
|
GO:0002831 |
55 |
0.052
|
Fly |
|
|
nucleoside monophosphate metabolic process
|
GO:0009123 |
191 |
0.052
|
|
|
|
regionalization
|
GO:0003002 |
29 |
0.052
|
Zebrafish |
|
|
muscle contraction
|
GO:0006936 |
73 |
0.052
|
|
|
|
response to molecule of bacterial origin
|
GO:0002237 |
82 |
0.052
|
|
|
|
ribonucleoprotein complex biogenesis
|
GO:0022613 |
116 |
0.051
|
|
|
|
cellular response to peptide
|
GO:1901653 |
59 |
0.050
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.050
|
|
|
|
protein maturation
|
GO:0051604 |
233 |
0.049
|
|
|
|
positive regulation of ion transport
|
GO:0043270 |
87 |
0.049
|
|
|
|
cellular response to cytokine stimulus
|
GO:0071345 |
181 |
0.048
|
|
|
|
regulation of macrophage derived foam cell differentiation
|
GO:0010743 |
14 |
0.048
|
|
|
|
transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0007178 |
125 |
0.048
|
|
|
|
regulation of protein ubiquitination
|
GO:0031396 |
95 |
0.048
|
|
|
|
cellular biogenic amine metabolic process
|
GO:0006576 |
34 |
0.048
|
|
|
|
regulation of ion transmembrane transport
|
GO:0034765 |
132 |
0.047
|
|
|
|
innate immune response activating signal transduction
|
GO:0002758 |
48 |
0.047
|
|
|
|
regulation of response to dna damage stimulus
|
GO:2001020 |
94 |
0.046
|
|
|
|
organophosphate biosynthetic process
|
GO:0090407 |
163 |
0.045
|
|
|
|
autophagy
|
GO:0006914 |
88 |
0.045
|
|
|
|
positive regulation of immune effector process
|
GO:0002699 |
40 |
0.043
|
Fly |
|
|
regulation of cellular amide metabolic process
|
GO:0034248 |
9 |
0.043
|
Fly |
|
|
organophosphate catabolic process
|
GO:0046434 |
430 |
0.043
|
|
|
|
neurogenesis
|
GO:0022008 |
169 |
0.043
|
|
|
|
cytokine biosynthetic process
|
GO:0042089 |
37 |
0.043
|
|
|
|
organic anion transport
|
GO:0015711 |
103 |
0.042
|
|
|
|
negative regulation of cell cycle process
|
GO:0010948 |
121 |
0.042
|
|
|
|
peptide biosynthetic process
|
GO:0043043 |
8 |
0.041
|
Fly |
|
|
chromatin modification
|
GO:0016568 |
298 |
0.041
|
|
|
|
reproduction
|
GO:0000003 |
63 |
0.041
|
|
|
|
cell projection organization
|
GO:0030030 |
252 |
0.041
|
|
|
|
response to wounding
|
GO:0009611 |
168 |
0.040
|
|
|
|
regulation of transmembrane transporter activity
|
GO:0022898 |
74 |
0.040
|
|
|
|
negative regulation of cell cycle
|
GO:0045786 |
193 |
0.040
|
|
|
|
ncrna metabolic process
|
GO:0034660 |
108 |
0.040
|
|
|
|
regulation of oxidoreductase activity
|
GO:0051341 |
43 |
0.040
|
|
|
|
negative regulation of transcription from rna polymerase ii promoter
|
GO:0000122 |
281 |
0.039
|
|
|
|
regulation of chromosome organization
|
GO:0033044 |
103 |
0.038
|
|
|
|
positive regulation of apoptotic process
|
GO:0043065 |
246 |
0.038
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
7 |
0.038
|
|
|
|
secretion by cell
|
GO:0032940 |
226 |
0.038
|
|
|
|
positive regulation of wnt signaling pathway
|
GO:0030177 |
54 |
0.037
|
|
|
|
protein import into nucleus
|
GO:0006606 |
104 |
0.037
|
|
|
|
regulation of protein processing
|
GO:0070613 |
150 |
0.036
|
|
|
|
lipid modification
|
GO:0030258 |
84 |
0.036
|
|
|
|
cytoplasmic pattern recognition receptor signaling pathway
|
GO:0002753 |
12 |
0.036
|
|
|
|
regulation of peptidase activity
|
GO:0052547 |
180 |
0.036
|
|
|
|
response to fungus
|
GO:0009620 |
4 |
0.035
|
|
|
|
ribonucleoside triphosphate metabolic process
|
GO:0009199 |
412 |
0.035
|
|
|
|
establishment of protein localization to membrane
|
GO:0090150 |
121 |
0.035
|
|
|
|
protein targeting to nucleus
|
GO:0044744 |
104 |
0.034
|
|
|
|
cell cycle g1 s phase transition
|
GO:0044843 |
80 |
0.034
|
|
|
|
nucleoside triphosphate metabolic process
|
GO:0009141 |
422 |
0.033
|
|
|
|
cellular response to oxidative stress
|
GO:0034599 |
85 |
0.033
|
|
|
|
atp metabolic process
|
GO:0046034 |
176 |
0.033
|
|
|
|
response to growth factor
|
GO:0070848 |
205 |
0.033
|
|
|
|
regulation of cell growth
|
GO:0001558 |
135 |
0.033
|
|
|
|
endocytosis
|
GO:0006897 |
159 |
0.032
|
|
|
|
nucleotide binding oligomerization domain containing 2 signaling pathway
|
GO:0070431 |
4 |
0.032
|
|
|
|
lipoprotein metabolic process
|
GO:0042157 |
42 |
0.032
|
|
|
|
jak stat cascade
|
GO:0007259 |
46 |
0.032
|
|
|
|
embryonic morphogenesis
|
GO:0048598 |
85 |
0.032
|
Zebrafish |
|
|
positive regulation of cytokine production
|
GO:0001819 |
167 |
0.032
|
Human |
|
|
ribonucleoside triphosphate catabolic process
|
GO:0009203 |
391 |
0.032
|
|
|
|
actin filament based movement
|
GO:0030048 |
17 |
0.031
|
|
|
|
regulation of neuron death
|
GO:1901214 |
56 |
0.031
|
|
|
|
dna damage response signal transduction by p53 class mediator
|
GO:0030330 |
44 |
0.031
|
|
|
|
positive regulation of stress activated mapk cascade
|
GO:0032874 |
60 |
0.031
|
|
|
|
regulation of homeostatic process
|
GO:0032844 |
121 |
0.030
|
|
|
|
positive regulation of cell cycle
|
GO:0045787 |
140 |
0.030
|
|
|
|
positive regulation of chromosome organization
|
GO:2001252 |
41 |
0.030
|
|
|
|
aging
|
GO:0007568 |
66 |
0.030
|
|
|
|
cellular response to nutrient levels
|
GO:0031669 |
69 |
0.030
|
|
|
|
protein processing
|
GO:0016485 |
226 |
0.030
|
|
|
|
regulation of dna repair
|
GO:0006282 |
47 |
0.030
|
|
|
|
regulation of cellular response to growth factor stimulus
|
GO:0090287 |
76 |
0.029
|
|
|
|
positive regulation of peptidase activity
|
GO:0010952 |
88 |
0.029
|
|
|
|
negative regulation of nf kappab transcription factor activity
|
GO:0032088 |
51 |
0.029
|
|
|
|
regulation of protein modification by small protein conjugation or removal
|
GO:1903320 |
107 |
0.029
|
|
|
|
response to oxidative stress
|
GO:0006979 |
121 |
0.029
|
|
|
|
phagocytosis
|
GO:0006909 |
42 |
0.029
|
|
|
|
positive regulation of erk1 and erk2 cascade
|
GO:0070374 |
75 |
0.029
|
|
|
|
protein ubiquitination
|
GO:0016567 |
314 |
0.029
|
|
|
|
regulation of transmembrane transport
|
GO:0034762 |
139 |
0.029
|
|
|
|
membrane lipid metabolic process
|
GO:0006643 |
53 |
0.029
|
|
|
|
peptidyl threonine phosphorylation
|
GO:0018107 |
41 |
0.028
|
|
|
|
regulation of mitotic cell cycle
|
GO:0007346 |
189 |
0.028
|
|
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.028
|
|
|
|
cell cycle checkpoint
|
GO:0000075 |
117 |
0.028
|
|
|
|
nucleocytoplasmic transport
|
GO:0006913 |
176 |
0.028
|
|
|
|
negative regulation of cellular amine metabolic process
|
GO:0033239 |
3 |
0.028
|
|
|
|
regulation of protein complex assembly
|
GO:0043254 |
147 |
0.027
|
|
|
|
wound healing
|
GO:0042060 |
115 |
0.027
|
|
|
|
calcium ion transport
|
GO:0006816 |
147 |
0.027
|
|
|
|
dna replication
|
GO:0006260 |
116 |
0.027
|
|
|
|
ossification
|
GO:0001503 |
121 |
0.027
|
|
|
|
regulation of intracellular transport
|
GO:0032386 |
195 |
0.027
|
|
|
|
positive regulation of translation
|
GO:0045727 |
35 |
0.027
|
|
|
|
g2 dna damage checkpoint
|
GO:0031572 |
26 |
0.027
|
|
|
|
microtubule cytoskeleton organization
|
GO:0000226 |
176 |
0.027
|
|
|
|
nuclear division
|
GO:0000280 |
128 |
0.026
|
|
|
|
negative regulation of intracellular transport
|
GO:0032387 |
60 |
0.026
|
|
|
|
chromosome segregation
|
GO:0007059 |
114 |
0.026
|
|
|
|
chromatin organization
|
GO:0006325 |
351 |
0.026
|
|
|
|
cell division
|
GO:0051301 |
168 |
0.026
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.026
|
|
|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
181 |
0.026
|
|
|
|
regulation of canonical wnt signaling pathway
|
GO:0060828 |
88 |
0.026
|
|
|
|
regulation of protein targeting
|
GO:1903533 |
91 |
0.026
|
|
|
|
positive regulation of hyaluronan biosynthetic process
|
GO:1900127 |
3 |
0.026
|
|
|
|
regulation of proteasomal protein catabolic process
|
GO:0061136 |
87 |
0.026
|
|
|
|
cell part morphogenesis
|
GO:0032990 |
137 |
0.026
|
|
|
|
mitochondrial transport
|
GO:0006839 |
60 |
0.026
|
|
|
|
plasma membrane organization
|
GO:0007009 |
115 |
0.026
|
|
|
|
single organism reproductive process
|
GO:0044702 |
98 |
0.025
|
|
|
|
hematopoietic or lymphoid organ development
|
GO:0048534 |
186 |
0.025
|
Mouse |
|
|
phosphatidylinositol metabolic process
|
GO:0046488 |
53 |
0.025
|
|
|
|
cell activation
|
GO:0001775 |
213 |
0.025
|
|
|
|
regulation of peptide transport
|
GO:0090087 |
62 |
0.025
|
|
|
|
mitotic cell cycle checkpoint
|
GO:0007093 |
68 |
0.025
|
|
|
|
intrinsic apoptotic signaling pathway by p53 class mediator
|
GO:0072332 |
37 |
0.024
|
|
|
|
regulation of monooxygenase activity
|
GO:0032768 |
22 |
0.024
|
|
|
|
heart development
|
GO:0007507 |
95 |
0.024
|
|
|
|
negative regulation of protein modification by small protein conjugation or removal
|
GO:1903321 |
41 |
0.024
|
|
|
|
nucleoside triphosphate catabolic process
|
GO:0009143 |
394 |
0.024
|
|
|
|
ubiquitin dependent protein catabolic process
|
GO:0006511 |
206 |
0.023
|
|
|
|
positive regulation of interferon beta production
|
GO:0032728 |
17 |
0.023
|
Human |
|
|
regulation of cysteine type endopeptidase activity
|
GO:2000116 |
127 |
0.023
|
|
|
|
organ morphogenesis
|
GO:0009887 |
147 |
0.023
|
Mouse |
|
|
nf kappab import into nucleus
|
GO:0042348 |
22 |
0.023
|
|
|
|
meiosis i
|
GO:0007127 |
4 |
0.023
|
|
|
|
membrane organization
|
GO:0061024 |
292 |
0.023
|
|
|
|
neuron development
|
GO:0048666 |
113 |
0.022
|
|
|
|
protein modification by small protein conjugation
|
GO:0032446 |
342 |
0.022
|
|
|
|
rna processing
|
GO:0006396 |
255 |
0.022
|
|
|
|
circulatory system development
|
GO:0072359 |
262 |
0.022
|
|
|
|
response to organonitrogen compound
|
GO:0010243 |
156 |
0.022
|
|
|
|
regulation of endopeptidase activity
|
GO:0052548 |
170 |
0.022
|
|
|
|
regulation of protein secretion
|
GO:0050708 |
86 |
0.022
|
|
|
|
response to tumor necrosis factor
|
GO:0034612 |
76 |
0.022
|
|
|
|
posttranscriptional regulation of gene expression
|
GO:0010608 |
213 |
0.022
|
|
|
|
regulation of production of molecular mediator of immune response
|
GO:0002700 |
25 |
0.022
|
Fly |
|
|
developmental process involved in reproduction
|
GO:0003006 |
66 |
0.022
|
|
|
|
negative regulation of nf kappab import into nucleus
|
GO:0042347 |
12 |
0.021
|
|
|
|
positive regulation of intracellular protein transport
|
GO:0090316 |
76 |
0.021
|
|
|
|
neuromuscular junction development
|
GO:0007528 |
3 |
0.021
|
|
|
|
lipoprotein biosynthetic process
|
GO:0042158 |
33 |
0.021
|
|
|
|
response to inorganic substance
|
GO:0010035 |
127 |
0.021
|
|
|
|
glycolipid metabolic process
|
GO:0006664 |
27 |
0.021
|
|
|
|
meiotic chromosome segregation
|
GO:0045132 |
4 |
0.020
|
|
|
|
regulation of protein catabolic process
|
GO:0042176 |
155 |
0.020
|
|
|
|
transcription factor import into nucleus
|
GO:0042991 |
40 |
0.020
|
|
|
|
embryonic epithelial tube formation
|
GO:0001838 |
4 |
0.020
|
|
|
|
positive regulation of cellular component organization
|
GO:0051130 |
376 |
0.020
|
|
|
|
carbohydrate biosynthetic process
|
GO:0016051 |
42 |
0.020
|
|
|
|
purine ribonucleoside triphosphate catabolic process
|
GO:0009207 |
391 |
0.020
|
|
|
|
signal transduction involved in dna damage checkpoint
|
GO:0072422 |
15 |
0.020
|
|
|
|
interferon beta production
|
GO:0032608 |
23 |
0.020
|
Human |
|
|
multicellular organism reproduction
|
GO:0032504 |
42 |
0.019
|
|
|
|
positive regulation of lipid transport
|
GO:0032370 |
22 |
0.019
|
|
|
|
positive regulation of interferon alpha production
|
GO:0032727 |
11 |
0.019
|
Human |
|
|
establishment of organelle localization
|
GO:0051656 |
59 |
0.019
|
|
|
|
smad protein complex assembly
|
GO:0007183 |
12 |
0.019
|
|
|
|
gastrulation
|
GO:0007369 |
51 |
0.019
|
Zebrafish |
|
|
divalent inorganic cation transport
|
GO:0072511 |
158 |
0.019
|
|
|
|
establishment or maintenance of cell polarity
|
GO:0007163 |
31 |
0.019
|
|
|
|
response to lipopolysaccharide
|
GO:0032496 |
70 |
0.018
|
|
|
|
cell morphogenesis involved in neuron differentiation
|
GO:0048667 |
44 |
0.018
|
|
|
|
regulation of anatomical structure size
|
GO:0090066 |
101 |
0.018
|
|
|
|
purine ribonucleoside monophosphate catabolic process
|
GO:0009169 |
158 |
0.018
|
|
|
|
meiotic cell cycle
|
GO:0051321 |
13 |
0.018
|
|
|
|
sister chromatid segregation
|
GO:0000819 |
54 |
0.018
|
|
|
|
regulation of calcium ion transport
|
GO:0051924 |
79 |
0.018
|
|
|
|
purine nucleoside monophosphate metabolic process
|
GO:0009126 |
186 |
0.018
|
|
|
|
protein oligomerization
|
GO:0051259 |
173 |
0.018
|
|
|
|
negative regulation of cytokine production
|
GO:0001818 |
82 |
0.018
|
|
|
|
protein localization to plasma membrane
|
GO:0072659 |
93 |
0.017
|
|
|
|
replicative cell aging
|
GO:0001302 |
3 |
0.017
|
|
|
|
glycoprotein biosynthetic process
|
GO:0009101 |
91 |
0.017
|
|
|
|
organelle localization
|
GO:0051640 |
84 |
0.017
|
|
|
|
activation of innate immune response
|
GO:0002218 |
55 |
0.017
|
|
|
|
glycerolipid biosynthetic process
|
GO:0045017 |
51 |
0.017
|
|
|
|
cellular response to transforming growth factor beta stimulus
|
GO:0071560 |
94 |
0.017
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
80 |
0.017
|
|
|
|
regulation of reactive oxygen species metabolic process
|
GO:2000377 |
41 |
0.017
|
|
|
|
cholesterol efflux
|
GO:0033344 |
28 |
0.017
|
|
|
|
negative regulation of cellular amino acid metabolic process
|
GO:0045763 |
2 |
0.017
|
|
|
|
negative regulation of interferon beta production
|
GO:0032688 |
4 |
0.017
|
|
|
|
endomembrane system organization
|
GO:0010256 |
196 |
0.017
|
|
|
|
cellular response to external stimulus
|
GO:0071496 |
111 |
0.016
|
|
|
|
glycerophospholipid biosynthetic process
|
GO:0046474 |
40 |
0.016
|
|
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.016
|
Zebrafish |
|
|
regulation of cytoplasmic transport
|
GO:1903649 |
149 |
0.016
|
|
|
|
immune response activating signal transduction
|
GO:0002757 |
90 |
0.016
|
|
|
|
protein lipidation
|
GO:0006497 |
33 |
0.016
|
|
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
411 |
0.016
|
|
|
|
organelle assembly
|
GO:0070925 |
176 |
0.016
|
|
|
|
cellular response to reactive oxygen species
|
GO:0034614 |
50 |
0.015
|
|
|
|
positive regulation of map kinase activity
|
GO:0043406 |
80 |
0.015
|
|
|
|
regulation of proteolysis
|
GO:0030162 |
293 |
0.015
|
|
|
|
regulation of protein transport
|
GO:0051223 |
213 |
0.015
|
|
|
|
atp catabolic process
|
GO:0006200 |
157 |
0.015
|
|
