Homo sapiens

17 known processes

COPS4

COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)

(Aliases: CSN4,MGC10899,MGC15160)

COPS4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein deneddylation GO:0000338 10 1.000
cullin deneddylation GO:0010388 9 0.997
protein modification by small protein removal GO:0070646 92 0.993
positive regulation of synaptic vesicle transport GO:1902805 1 0.970
cytokinesis GO:0000910 96 0.885
Worm
regulation of catecholamine uptake involved in synaptic transmission GO:0051940 4 0.841
g2 dna damage checkpoint GO:0031572 26 0.832
Fly
regulation of synaptic transmission dopaminergic GO:0032225 4 0.824
regulation of synaptic vesicle endocytosis GO:1900242 1 0.812
regulation of synaptic vesicle recycling GO:1903421 1 0.765
regulation of neurotransmitter uptake GO:0051580 4 0.761
mitotic cell cycle phase transition GO:0044772 162 0.748
Fly
negative regulation of cell cycle phase transition GO:1901988 89 0.744
Fly
regulation of dopamine uptake involved in synaptic transmission GO:0051584 4 0.722
endoplasmic reticulum organization GO:0007029 20 0.713
positive regulation of synaptic vesicle recycling GO:1903423 1 0.711
cyclin catabolic process GO:0008054 6 0.700
mitotic cell cycle checkpoint GO:0007093 68 0.688
Fly
positive regulation of synaptic vesicle endocytosis GO:1900244 1 0.682
negative regulation of cell cycle process GO:0010948 121 0.681
Fly
regulation of cell cycle process GO:0010564 266 0.669
Fly
regulation of cell cycle GO:0051726 393 0.595
Fly
mitotic dna damage checkpoint GO:0044773 28 0.551
Fly
dopamine uptake GO:0090494 4 0.540
mitotic cell cycle GO:0000278 326 0.539
Fly
regulation of mitotic cell cycle GO:0007346 189 0.531
Fly
cell cycle checkpoint GO:0000075 117 0.529
Fly
ubiquitin dependent protein catabolic process GO:0006511 206 0.510
Fly
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.489
Fly
regulation of mitotic cell cycle phase transition GO:1901990 118 0.478
Fly
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.465
Fly
nucleoside monophosphate metabolic process GO:0009123 191 0.455
cellular protein catabolic process GO:0044257 261 0.411
Fly
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.387
atp catabolic process GO:0006200 157 0.378
mitotic cell cycle process GO:1903047 286 0.364
Fly
single organism cellular localization GO:1902580 332 0.315
dopamine transport GO:0015872 5 0.312
protein modification by small protein conjugation GO:0032446 342 0.306
mitotic dna integrity checkpoint GO:0044774 30 0.304
Fly
cellular response to dna damage stimulus GO:0006974 379 0.288
Fly
glial cell migration GO:0008347 4 0.284
cell division GO:0051301 168 0.273
Worm
negative regulation of cell cycle GO:0045786 193 0.271
Fly
cell cycle phase transition GO:0044770 173 0.270
Fly
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.268
cell cell signaling GO:0007267 155 0.264
Fly
ribonucleoside monophosphate metabolic process GO:0009161 187 0.258
regulation of kinase activity GO:0043549 314 0.257
post embryonic development GO:0009791 2 0.254
Worm
positive regulation of catabolic process GO:0009896 310 0.254
ribonucleoside monophosphate catabolic process GO:0009158 158 0.252
nucleoside monophosphate catabolic process GO:0009125 159 0.250
regulation of cell cycle phase transition GO:1901987 126 0.250
Fly
dna integrity checkpoint GO:0031570 71 0.249
Fly
organelle localization GO:0051640 84 0.248
positive regulation of phosphorylation GO:0042327 394 0.248
dopamine uptake involved in synaptic transmission GO:0051583 4 0.246
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.245
mitotic g2 m transition checkpoint GO:0044818 9 0.231
Fly
catecholamine transport GO:0051937 6 0.228
generation of neurons GO:0048699 152 0.225
Fly
purine nucleoside monophosphate metabolic process GO:0009126 186 0.209
nervous system development GO:0007399 293 0.208
Fly
purine nucleoside monophosphate catabolic process GO:0009128 158 0.203
positive regulation of transport GO:0051050 336 0.200
microtubule based process GO:0007017 210 0.179
regulation of transferase activity GO:0051338 355 0.179
establishment of organelle localization GO:0051656 59 0.173
negative regulation of cell proliferation GO:0008285 228 0.162
neuron differentiation GO:0030182 138 0.148
Fly
activation of protein kinase activity GO:0032147 90 0.147
negative regulation of mitotic cell cycle GO:0045930 102 0.146
Fly
atp metabolic process GO:0046034 176 0.146
purine nucleoside triphosphate catabolic process GO:0009146 392 0.141
nik nf kappab signaling GO:0038061 12 0.139
regulation of protein localization GO:0032880 296 0.138
regulation of amine transport GO:0051952 5 0.136
cellular macromolecule catabolic process GO:0044265 380 0.135
Fly
protein oligomerization GO:0051259 173 0.135
purine ribonucleotide catabolic process GO:0009154 404 0.134
positive regulation of synaptic transmission GO:0050806 4 0.133
dna damage checkpoint GO:0000077 68 0.132
Fly
positive regulation of protein phosphorylation GO:0001934 313 0.130
ribonucleotide catabolic process GO:0009261 405 0.128
nucleotide catabolic process GO:0009166 408 0.124
positive regulation of cellular component organization GO:0051130 376 0.124
protein localization to organelle GO:0033365 280 0.119
regulation of mitosis GO:0007088 63 0.116
neuron development GO:0048666 113 0.112
protein folding GO:0006457 38 0.108
anterior posterior axis specification embryo GO:0008595 2 0.108
posttranscriptional regulation of gene expression GO:0010608 213 0.108
Fly
vesicle mediated transport GO:0016192 371 0.107
modification dependent macromolecule catabolic process GO:0043632 212 0.102
Fly
establishment of vesicle localization GO:0051650 23 0.100
cell projection organization GO:0030030 252 0.097
nucleoside triphosphate metabolic process GO:0009141 422 0.094
positive regulation of transferase activity GO:0051347 227 0.091
protein polyubiquitination GO:0000209 110 0.091
protein homooligomerization GO:0051260 100 0.091
regulation of cellular amine metabolic process GO:0033238 11 0.089
positive regulation of organelle organization GO:0010638 195 0.088
purine ribonucleoside catabolic process GO:0046130 398 0.088
endocytosis GO:0006897 159 0.085
cellular amine metabolic process GO:0044106 41 0.084
regulation of protein kinase activity GO:0045859 289 0.084
positive regulation of cell cycle GO:0045787 140 0.081
purine ribonucleoside metabolic process GO:0046128 437 0.080
cell cell signaling involved in cell fate commitment GO:0045168 5 0.079
Fly
purine nucleotide catabolic process GO:0006195 405 0.078
protein catabolic process GO:0030163 325 0.078
Fly
neuron projection development GO:0031175 106 0.068
modification dependent protein catabolic process GO:0019941 209 0.068
Fly
embryo development GO:0009790 123 0.067
Worm
chaperone mediated protein transport GO:0072321 5 0.067
blastoderm segmentation GO:0007350 2 0.066
protein localization to nucleus GO:0034504 136 0.066
tripartite regional subdivision GO:0007351 2 0.066
positive regulation of kinase activity GO:0033674 204 0.066
nucleoside catabolic process GO:0009164 408 0.065
regulation of protein serine threonine kinase activity GO:0071900 179 0.064
mapk cascade GO:0000165 288 0.063
positive regulation of protein catabolic process GO:0045732 75 0.062
neurogenesis GO:0022008 169 0.061
Fly
positive regulation of nucleotide catabolic process GO:0030813 185 0.059
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.059
positive regulation of cellular amine metabolic process GO:0033240 7 0.058
regulation of protein transport GO:0051223 213 0.057
positive regulation of cell cycle process GO:0090068 106 0.057
microtubule cytoskeleton organization GO:0000226 176 0.056
segmentation GO:0035282 4 0.055
positive regulation of protein kinase activity GO:0045860 190 0.054
female gamete generation GO:0007292 2 0.052
proteasomal protein catabolic process GO:0010498 176 0.049
Fly
catecholamine uptake involved in synaptic transmission GO:0051934 4 0.049
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.048
positive regulation of cellular catabolic process GO:0031331 284 0.048
regulation of protein stability GO:0031647 87 0.047
Fly
multicellular organismal response to stress GO:0033555 1 0.046
protein deubiquitination GO:0016579 79 0.043
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.043
Fly
mitotic cytokinesis GO:0000281 19 0.042
peptidyl lysine modification GO:0018205 144 0.041
ribonucleoside triphosphate catabolic process GO:0009203 391 0.041
protein ubiquitination GO:0016567 314 0.041
membrane organization GO:0061024 292 0.041
positive regulation of protein transport GO:0051222 135 0.039
regulation of protein catabolic process GO:0042176 155 0.039
Fly
purine containing compound catabolic process GO:0072523 411 0.039
positive regulation of meiotic cell cycle GO:0051446 2 0.039
catecholamine uptake GO:0090493 4 0.038
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.037
internal protein amino acid acetylation GO:0006475 101 0.037
establishment of nucleus localization GO:0040023 1 0.036
nucleoside triphosphate catabolic process GO:0009143 394 0.036
nucleocytoplasmic transport GO:0006913 176 0.036
ribonucleoside triphosphate metabolic process GO:0009199 412 0.036
regulation of metaphase anaphase transition of cell cycle GO:1902099 26 0.036
lipid metabolic process GO:0006629 381 0.035
adult locomotory behavior GO:0008344 1 0.035
chromatin organization GO:0006325 351 0.035
protein stabilization GO:0050821 64 0.035
Fly
protein monoubiquitination GO:0006513 39 0.034
amine metabolic process GO:0009308 44 0.034
neurotransmitter transport GO:0006836 10 0.033
neurotransmitter uptake GO:0001504 5 0.033
regulation of sister chromatid segregation GO:0033045 27 0.032
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.032
purine nucleoside triphosphate metabolic process GO:0009144 412 0.032
synaptic transmission dopaminergic GO:0001963 5 0.032
positive regulation of nucleoside metabolic process GO:0045979 186 0.032
regulation of establishment of protein localization GO:0070201 242 0.032
regulation of mitotic sister chromatid segregation GO:0033047 27 0.031
rho protein signal transduction GO:0007266 26 0.031
positive regulation of hydrolase activity GO:0051345 331 0.031
cellular macromolecular complex assembly GO:0034622 324 0.031
cation transport GO:0006812 331 0.030
ribonucleoside catabolic process GO:0042454 406 0.030
lipid biosynthetic process GO:0008610 177 0.030
endomembrane system organization GO:0010256 196 0.030
cytoskeleton dependent cytokinesis GO:0061640 22 0.029
vesicle localization GO:0051648 26 0.029
purine nucleoside catabolic process GO:0006152 398 0.029
determination of adult lifespan GO:0008340 2 0.028
regulation of transcription factor import into nucleus GO:0042990 39 0.028
histone h2a ubiquitination GO:0033522 17 0.028
synaptic vesicle endocytosis GO:0048488 2 0.028
regulation of meiotic cell cycle GO:0051445 4 0.028
regulation of intracellular protein transport GO:0033157 123 0.028
neuron neuron synaptic transmission GO:0007270 6 0.028
regulation of atpase activity GO:0043462 25 0.028
response to abiotic stimulus GO:0009628 336 0.027
biological adhesion GO:0022610 331 0.027
secretion GO:0046903 254 0.027
small molecule biosynthetic process GO:0044283 157 0.027
regulation of nik nf kappab signaling GO:1901222 11 0.027
multicellular organismal aging GO:0010259 3 0.027
locomotory behavior GO:0007626 1 0.027
single organism nuclear import GO:1902593 104 0.026
regulation of cellular component biogenesis GO:0044087 281 0.026
nucleotide excision repair GO:0006289 31 0.026
regulation of cellular amino acid metabolic process GO:0006521 6 0.026
nucleoside phosphate catabolic process GO:1901292 412 0.026
anterior posterior axis specification GO:0009948 2 0.026
positive regulation of atpase activity GO:0032781 19 0.025
oogenesis GO:0048477 2 0.025
nitrogen compound transport GO:0071705 191 0.025
chaperone mediated protein folding GO:0061077 13 0.025
cellular amino acid metabolic process GO:0006520 116 0.025
positive regulation of intracellular protein transport GO:0090316 76 0.024
cell development GO:0048468 328 0.024
covalent chromatin modification GO:0016569 254 0.024
regulation of neurotransmitter levels GO:0001505 15 0.024
regulation of proteolysis GO:0030162 293 0.024
Fly
positive regulation of nucleotide metabolic process GO:0045981 230 0.024
positive regulation of mitotic cell cycle GO:0045931 60 0.023
regulation of vesicle mediated transport GO:0060627 130 0.023
signal transduction by phosphorylation GO:0023014 297 0.023
nuclear import GO:0051170 106 0.023
regulation of mapk cascade GO:0043408 262 0.023
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 30 0.022
positive regulation of proteasomal protein catabolic process GO:1901800 35 0.022
jnk cascade GO:0007254 80 0.022
intermediate filament cytoskeleton organization GO:0045104 17 0.022
negative regulation of protein metabolic process GO:0051248 391 0.022
Fly
cell cycle arrest GO:0007050 71 0.022
regulation of locomotion GO:0040012 329 0.021
establishment of spindle localization GO:0051293 12 0.021
organ formation GO:0048645 3 0.021
organophosphate catabolic process GO:0046434 430 0.021
glycosyl compound catabolic process GO:1901658 413 0.021
nucleus localization GO:0051647 1 0.021
regulation of cellular response to stress GO:0080135 244 0.021
regulation of cellular ketone metabolic process GO:0010565 50 0.020
synaptic vesicle transport GO:0048489 5 0.020
single organism membrane organization GO:0044802 268 0.020
protein targeting to nucleus GO:0044744 104 0.020
establishment of mitotic spindle localization GO:0040001 8 0.020
regulation of ion transport GO:0043269 189 0.020
protein import into nucleus GO:0006606 104 0.019
secretion by cell GO:0032940 226 0.019
exocytosis GO:0006887 71 0.019
mitotic g2 dna damage checkpoint GO:0007095 7 0.019
Fly
spermatid differentiation GO:0048515 4 0.019
protein maturation GO:0051604 233 0.019
Fly
negative regulation of protein phosphorylation GO:0001933 140 0.019
response to oxidative stress GO:0006979 121 0.019
regulation of cytoplasmic transport GO:1903649 149 0.018
alcohol metabolic process GO:0006066 114 0.018
negative regulation of catalytic activity GO:0043086 335 0.018
monovalent inorganic cation transport GO:0015672 128 0.018
mitotic sister chromatid separation GO:0051306 18 0.018
protein targeting GO:0006605 187 0.018
optic nerve development GO:0021554 2 0.017
monocarboxylic acid biosynthetic process GO:0072330 67 0.017
positive regulation of nik nf kappab signaling GO:1901224 10 0.017
positive regulation of proteolysis GO:0045862 142 0.017
negative regulation of protein modification process GO:0031400 200 0.017
histone h2a monoubiquitination GO:0035518 11 0.016
regulation of protein import into nucleus GO:0042306 78 0.016
positive regulation of cellular protein catabolic process GO:1903364 37 0.016
neurotransmitter secretion GO:0007269 4 0.016
positive regulation of alcohol biosynthetic process GO:1902932 9 0.016
cell activation GO:0001775 213 0.016
protein import GO:0017038 130 0.016
intracellular protein transport GO:0006886 270 0.016
regulation of nucleocytoplasmic transport GO:0046822 98 0.016
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 35 0.015
protein acetylation GO:0006473 116 0.015
positive regulation of cytoplasmic transport GO:1903651 82 0.015
negative regulation of protein maturation GO:1903318 142 0.015
Fly
regulation of endocytosis GO:0030100 72 0.015
regulation of cellular component movement GO:0051270 334 0.015
monoamine transport GO:0015844 10 0.015
regulation of intracellular transport GO:0032386 195 0.015
mitotic nuclear division GO:0007067 119 0.015
organic hydroxy compound metabolic process GO:1901615 147 0.015
cellular ketone metabolic process GO:0042180 80 0.014
regulation of chromosome segregation GO:0051983 44 0.014
hindbrain development GO:0030902 3 0.014
regulation of chromosome organization GO:0033044 103 0.014
chromosome separation GO:0051304 23 0.014
positive regulation of steroid metabolic process GO:0045940 13 0.014
cellular component morphogenesis GO:0032989 314 0.014
regulation of protein localization to cell surface GO:2000008 15 0.014
regulation of g2 m transition of mitotic cell cycle GO:0010389 20 0.014
negative regulation of intracellular signal transduction GO:1902532 183 0.014
synaptic transmission GO:0007268 61 0.014
cell cycle g1 s phase transition GO:0044843 80 0.014
cellular chemical homeostasis GO:0055082 180 0.013
response to organic cyclic compound GO:0014070 204 0.013
dna conformation change GO:0071103 113 0.013
reproductive structure development GO:0048608 55 0.013
Worm
negative regulation of apoptotic process GO:0043066 316 0.013
nuclear migration GO:0007097 1 0.013
transcription factor import into nucleus GO:0042991 40 0.013
phagocytosis GO:0006909 42 0.013
oocyte differentiation GO:0009994 2 0.013
neuromuscular junction development GO:0007528 3 0.013
chromatin modification GO:0016568 298 0.013
regulation of cell cycle g1 s phase transition GO:1902806 42 0.013
response to calcium ion GO:0051592 46 0.012
nuclear transport GO:0051169 179 0.012
carboxylic acid biosynthetic process GO:0046394 97 0.012
reproductive process GO:0022414 106 0.012
Worm
striated muscle tissue development GO:0014706 59 0.012
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.012
Fly
neuron remodeling GO:0016322 2 0.012
positive regulation of cell proliferation GO:0008284 301 0.012
cell part morphogenesis GO:0032990 137 0.012
ncrna processing GO:0034470 83 0.012
protein dna complex subunit organization GO:0071824 80 0.012
response to hormone GO:0009725 175 0.012
positive regulation of protein kinase a signaling GO:0010739 4 0.012
response to radiation GO:0009314 151 0.012
positive regulation of chromatin modification GO:1903310 30 0.012
maintenance of location GO:0051235 112 0.012
eosinophil mediated immunity GO:0002447 2 0.012
chemical homeostasis GO:0048878 306 0.012
cell morphogenesis GO:0000902 296 0.011
cytoplasmic transport GO:0016482 379 0.011
multicellular organismal reproductive process GO:0048609 40 0.011
behavior GO:0007610 112 0.011
internal peptidyl lysine acetylation GO:0018393 97 0.011
regulation of mitotic metaphase anaphase transition GO:0030071 26 0.011
negative regulation of multicellular organismal process GO:0051241 317 0.011
negative regulation of programmed cell death GO:0043069 321 0.011
actin filament based process GO:0030029 224 0.011
positive regulation of transcription factor import into nucleus GO:0042993 25 0.011
blood vessel development GO:0001568 172 0.011
regulation of cytokine production GO:0001817 232 0.011
regulation of nucleotide metabolic process GO:0006140 269 0.011
steroid metabolic process GO:0008202 94 0.011
stress activated protein kinase signaling cascade GO:0031098 94 0.010
regulation of microtubule based process GO:0032886 74 0.010
negative regulation of protein kinase activity GO:0006469 98 0.010
regulation of protein localization to nucleus GO:1900180 85 0.010
muscle organ development GO:0007517 56 0.010
blastocyst development GO:0001824 3 0.010
negative regulation of protein processing GO:0010955 142 0.010
Fly
positive regulation of cell death GO:0010942 263 0.010
regulation of response to biotic stimulus GO:0002831 55 0.010
response to uv GO:0009411 73 0.010
organophosphate biosynthetic process GO:0090407 163 0.010
sleep GO:0030431 2 0.010

COPS4 disease predictions

Disease DO term ID Size Probability Func Analog Org
nervous system disease DOID:863 431 0.100
brain disease DOID:936 73 0.100
central nervous system disease DOID:331 186 0.100
inherited metabolic disorder DOID:655 242 0.020
disease of metabolism DOID:0014667 295 0.020
amino acid metabolic disorder DOID:9252 50 0.013