Homo sapiens

17 known processes

COPS7A

COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis)

(Aliases: CSN7A,MGC110877)

COPS7A biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein deneddylation GO:0000338 10 0.460
protein modification by small protein removal GO:0070646 92 0.380
g2 dna damage checkpoint GO:0031572 26 0.329
Fly
cellular response to dna damage stimulus GO:0006974 379 0.265
Fly
oogenesis GO:0048477 2 0.204
negative regulation of cell cycle GO:0045786 193 0.170
Fly
female gamete generation GO:0007292 2 0.158
cell cycle checkpoint GO:0000075 117 0.156
Fly
positive regulation of phosphorylation GO:0042327 394 0.150
regulation of cell cycle GO:0051726 393 0.147
Fly
ubiquitin dependent protein catabolic process GO:0006511 206 0.144
regulation of protein serine threonine kinase activity GO:0071900 179 0.143
cell cell signaling GO:0007267 155 0.137
Fly
cellular amine metabolic process GO:0044106 41 0.135
regulation of mitotic cell cycle phase transition GO:1901990 118 0.135
Fly
regulation of cell cycle process GO:0010564 266 0.123
Fly
oocyte development GO:0048599 1 0.120
cullin deneddylation GO:0010388 9 0.119
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.115
oocyte differentiation GO:0009994 2 0.112
regulation of transferase activity GO:0051338 355 0.111
cell cycle phase transition GO:0044770 173 0.108
Fly
protein stabilization GO:0050821 64 0.106
Fly
positive regulation of protein phosphorylation GO:0001934 313 0.104
dna integrity checkpoint GO:0031570 71 0.103
Fly
negative regulation of cell cycle process GO:0010948 121 0.101
Fly
post embryonic development GO:0009791 2 0.098
regulation of cellular amino acid metabolic process GO:0006521 6 0.097
cytokinesis GO:0000910 96 0.095
cellular protein catabolic process GO:0044257 261 0.093
mitotic cell cycle phase transition GO:0044772 162 0.093
Fly
regulation of protein stability GO:0031647 87 0.091
Fly
regulation of cell cycle phase transition GO:1901987 126 0.089
Fly
negative regulation of cell cycle phase transition GO:1901988 89 0.087
Fly
amine metabolic process GO:0009308 44 0.087
positive regulation of cellular amine metabolic process GO:0033240 7 0.085
positive regulation of kinase activity GO:0033674 204 0.082
positive regulation of cytokine production GO:0001819 167 0.080
cellular lipid metabolic process GO:0044255 303 0.078
regulation of cellular amine metabolic process GO:0033238 11 0.078
cytoplasmic transport GO:0016482 379 0.078
cellular chemical homeostasis GO:0055082 180 0.076
regulation of mapk cascade GO:0043408 262 0.076
mapk cascade GO:0000165 288 0.076
negative regulation of cell proliferation GO:0008285 228 0.074
dna damage checkpoint GO:0000077 68 0.072
Fly
mitotic dna damage checkpoint GO:0044773 28 0.069
Fly
positive regulation of protein kinase activity GO:0045860 190 0.066
regulation of proteolysis GO:0030162 293 0.065
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.064
regulation of kinase activity GO:0043549 314 0.061
vesicle mediated transport GO:0016192 371 0.060
negative regulation of apoptotic process GO:0043066 316 0.059
protein modification by small protein conjugation GO:0032446 342 0.059
cellular amino acid metabolic process GO:0006520 116 0.059
protein catabolic process GO:0030163 325 0.056
cell cell signaling involved in cell fate commitment GO:0045168 5 0.055
Fly
ion homeostasis GO:0050801 230 0.055
mitotic cell cycle process GO:1903047 286 0.053
Fly
metal ion homeostasis GO:0055065 169 0.052
posttranscriptional regulation of gene expression GO:0010608 213 0.052
Fly
lipid metabolic process GO:0006629 381 0.051
positive regulation of hydrolase activity GO:0051345 331 0.051
mitotic cell cycle checkpoint GO:0007093 68 0.051
Fly
modification dependent macromolecule catabolic process GO:0043632 212 0.050
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.048
Fly
actin filament based process GO:0030029 224 0.047
regulation of protein kinase activity GO:0045859 289 0.046
chemical homeostasis GO:0048878 306 0.043
cytokine production GO:0001816 247 0.041
regulation of cellular ketone metabolic process GO:0010565 50 0.041
lipid biosynthetic process GO:0008610 177 0.040
proteasomal protein catabolic process GO:0010498 176 0.040
negative regulation of mitotic cell cycle GO:0045930 102 0.040
Fly
ras protein signal transduction GO:0007265 73 0.038
regulation of cellular component movement GO:0051270 334 0.038
golgi vesicle transport GO:0048193 80 0.038
regulation of secretion by cell GO:1903530 177 0.038
cellular macromolecule catabolic process GO:0044265 380 0.037
regulation of cytokine production GO:0001817 232 0.036
methylation GO:0032259 106 0.036
system process GO:0003008 349 0.036
modification dependent protein catabolic process GO:0019941 209 0.035
negative regulation of protein modification process GO:0031400 200 0.034
protein ubiquitination GO:0016567 314 0.034
cellular carbohydrate metabolic process GO:0044262 84 0.034
defense response to other organism GO:0098542 129 0.034
negative regulation of programmed cell death GO:0043069 321 0.033
multicellular organismal aging GO:0010259 3 0.033
regulation of cellular response to stress GO:0080135 244 0.033
protein deubiquitination GO:0016579 79 0.033
signal transduction by phosphorylation GO:0023014 297 0.032
generation of precursor metabolites and energy GO:0006091 68 0.032
defense response GO:0006952 315 0.032
locomotory behavior GO:0007626 1 0.032
small gtpase mediated signal transduction GO:0007264 78 0.031
positive regulation of transport GO:0051050 336 0.031
response to abiotic stimulus GO:0009628 336 0.031
negative regulation of cellular protein metabolic process GO:0032269 353 0.031
response to other organism GO:0051707 261 0.030
single organism carbohydrate metabolic process GO:0044723 193 0.030
cyclin catabolic process GO:0008054 6 0.030
regulation of establishment of protein localization GO:0070201 242 0.030
peripheral nervous system development GO:0007422 2 0.030
negative regulation of multicellular organismal process GO:0051241 317 0.030
cell development GO:0048468 328 0.030
cellular homeostasis GO:0019725 196 0.029
negative regulation of protein metabolic process GO:0051248 391 0.029
regulation of locomotion GO:0040012 329 0.029
jnk cascade GO:0007254 80 0.029
cellular component morphogenesis GO:0032989 314 0.029
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.029
cellular ketone metabolic process GO:0042180 80 0.029
stress activated mapk cascade GO:0051403 93 0.028
response to axon injury GO:0048678 1 0.028
biological adhesion GO:0022610 331 0.027
negative regulation of phosphate metabolic process GO:0045936 267 0.027
cell cycle arrest GO:0007050 71 0.027
immune effector process GO:0002252 159 0.027
regulation of reactive oxygen species metabolic process GO:2000377 41 0.026
protein maturation GO:0051604 233 0.026
secretion by cell GO:0032940 226 0.026
metal ion transport GO:0030001 272 0.026
nervous system development GO:0007399 293 0.026
cellular ion homeostasis GO:0006873 168 0.026
negative regulation of catalytic activity GO:0043086 335 0.025
transmembrane transport GO:0055085 399 0.025
positive regulation of secretion by cell GO:1903532 108 0.025
small molecule biosynthetic process GO:0044283 157 0.025
cellular metal ion homeostasis GO:0006875 146 0.024
intracellular protein transport GO:0006886 270 0.024
negative regulation of cell death GO:0060548 345 0.024
reproductive process GO:0022414 106 0.024
compound eye development GO:0048749 1 0.024
positive regulation of protein catabolic process GO:0045732 75 0.023
immune response GO:0006955 307 0.023
regulation of proteasomal protein catabolic process GO:0061136 87 0.023
regulation of protein maturation GO:1903317 150 0.023
single organism cellular localization GO:1902580 332 0.023
negative regulation of phosphorus metabolic process GO:0010563 267 0.023
cellular macromolecular complex assembly GO:0034622 324 0.023
positive regulation of proteolysis GO:0045862 142 0.023
regulation of cell differentiation GO:0045595 393 0.022
calcium ion transmembrane transport GO:0070588 76 0.022
protein localization to organelle GO:0033365 280 0.022
cardiac muscle cell contraction GO:0086003 4 0.022
segmentation GO:0035282 4 0.022
regulation of cellular component biogenesis GO:0044087 281 0.022
response to biotic stimulus GO:0009607 276 0.021
wnt signaling pathway GO:0016055 156 0.021
positive regulation of transferase activity GO:0051347 227 0.021
cell morphogenesis GO:0000902 296 0.021
endosomal transport GO:0016197 129 0.021
innate immune response GO:0045087 178 0.021
positive regulation of cellular component biogenesis GO:0044089 158 0.021
peptidyl tyrosine phosphorylation GO:0018108 170 0.021
mitotic dna integrity checkpoint GO:0044774 30 0.021
Fly
positive regulation of immune system process GO:0002684 283 0.021
cation homeostasis GO:0055080 189 0.020
regulation of protein catabolic process GO:0042176 155 0.020
regulation of protein processing GO:0070613 150 0.020
negative regulation of phosphorylation GO:0042326 174 0.020
apoptotic signaling pathway GO:0097190 268 0.020
regulation of cellular protein catabolic process GO:1903362 96 0.020
negative regulation of proteasomal protein catabolic process GO:1901799 32 0.019
positive regulation of cellular component organization GO:0051130 376 0.019
macromolecule glycosylation GO:0043413 63 0.019
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.019
visual learning GO:0008542 1 0.019
calcium ion transport GO:0006816 147 0.019
glial cell migration GO:0008347 4 0.019
regulation of ras protein signal transduction GO:0046578 155 0.019
negative regulation of protein processing GO:0010955 142 0.019
mitotic cell cycle GO:0000278 326 0.019
Fly
regulation of protein polymerization GO:0032271 63 0.019
positive regulation of mapk cascade GO:0043410 190 0.019
negative regulation of protein maturation GO:1903318 142 0.019
regulation of metal ion transport GO:0010959 120 0.019
organic hydroxy compound metabolic process GO:1901615 147 0.019
response to external biotic stimulus GO:0043207 261 0.019
stress activated protein kinase signaling cascade GO:0031098 94 0.019
inorganic cation transmembrane transport GO:0098662 194 0.019
defense response to virus GO:0051607 71 0.018
regulation of cell migration GO:0030334 289 0.018
regulation of anatomical structure size GO:0090066 101 0.018
regulation of erk1 and erk2 cascade GO:0070372 99 0.018
ribonucleoside monophosphate metabolic process GO:0009161 187 0.018
negative regulation of locomotion GO:0040013 118 0.018
cell communication by electrical coupling involved in cardiac conduction GO:0086064 3 0.017
positive regulation of phospholipase activity GO:0010518 22 0.017
cell adhesion GO:0007155 325 0.017
cell projection organization GO:0030030 252 0.017
activation of protein kinase activity GO:0032147 90 0.017
mitotic g2 dna damage checkpoint GO:0007095 7 0.017
Fly
actin mediated cell contraction GO:0070252 12 0.017
mitotic g2 m transition checkpoint GO:0044818 9 0.017
Fly
blastoderm segmentation GO:0007350 2 0.017
establishment or maintenance of apical basal cell polarity GO:0035088 2 0.017
determination of adult lifespan GO:0008340 2 0.016
secretion GO:0046903 254 0.016
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.016
regulation of cellular component size GO:0032535 82 0.016
intrinsic apoptotic signaling pathway GO:0097193 127 0.016
regulation of actin filament based process GO:0032970 141 0.016
sequestering of metal ion GO:0051238 24 0.016
protein polymerization GO:0051258 71 0.016
citrate metabolic process GO:0006101 2 0.016
positive regulation of apoptotic process GO:0043065 246 0.016
cellular protein complex assembly GO:0043623 188 0.016
positive regulation of cell proliferation GO:0008284 301 0.015
cellular response to oxygen containing compound GO:1901701 276 0.015
unsaturated fatty acid biosynthetic process GO:0006636 21 0.015
single organism reproductive process GO:0044702 98 0.015
cellular cation homeostasis GO:0030003 163 0.015
positive regulation of protein transport GO:0051222 135 0.015
response to endoplasmic reticulum stress GO:0034976 49 0.015
motor neuron axon guidance GO:0008045 2 0.015
maintenance of location GO:0051235 112 0.015
regulation of jnk cascade GO:0046328 73 0.015
hindbrain development GO:0030902 3 0.015
negative regulation of cell migration GO:0030336 102 0.015
positive regulation of organelle organization GO:0010638 195 0.015
monocarboxylic acid biosynthetic process GO:0072330 67 0.014
positive regulation of endopeptidase activity GO:0010950 84 0.014
negative regulation of intracellular signal transduction GO:1902532 183 0.014
positive regulation of catabolic process GO:0009896 310 0.014
regulation of growth GO:0040008 165 0.014
regulation of multi organism process GO:0043900 157 0.014
cation transport GO:0006812 331 0.014
sleep GO:0030431 2 0.014
regulation of response to external stimulus GO:0032101 222 0.014
negative regulation of kinase activity GO:0033673 106 0.014
cardiac muscle contraction GO:0060048 34 0.014
myosin filament assembly GO:0031034 2 0.014
purine ribonucleoside metabolic process GO:0046128 437 0.014
reproductive structure development GO:0048608 55 0.013
regulation of mitotic cell cycle GO:0007346 189 0.013
Fly
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.013
positive regulation of cellular protein catabolic process GO:1903364 37 0.013
cation transmembrane transport GO:0098655 238 0.013
regulation of response to biotic stimulus GO:0002831 55 0.013
regulation of cell morphogenesis GO:0022604 153 0.013
renal sodium ion absorption GO:0070294 2 0.013
regulation of intracellular protein transport GO:0033157 123 0.013
adult locomotory behavior GO:0008344 1 0.013
positive regulation of protein complex assembly GO:0031334 86 0.013
regulation of protein localization GO:0032880 296 0.013
hemopoiesis GO:0030097 180 0.013
actin polymerization or depolymerization GO:0008154 56 0.013
endocytosis GO:0006897 159 0.013
chemotaxis GO:0006935 157 0.013
inorganic ion transmembrane transport GO:0098660 231 0.013
protein acylation GO:0043543 138 0.013
regulation of peptidyl serine phosphorylation GO:0033135 50 0.013
negative regulation of transport GO:0051051 176 0.013
reproduction GO:0000003 63 0.013
response to calcium ion GO:0051592 46 0.013
negative regulation of protein catabolic process GO:0042177 59 0.013
regulation of protein transport GO:0051223 213 0.013
regulation of protein secretion GO:0050708 86 0.013
actin filament based movement GO:0030048 17 0.013
regulation of apoptotic signaling pathway GO:2001233 175 0.013
purine nucleoside triphosphate metabolic process GO:0009144 412 0.013
response to bacterium GO:0009617 144 0.012
maintenance of cell polarity GO:0030011 2 0.012
dephosphorylation GO:0016311 209 0.012
neuron differentiation GO:0030182 138 0.012
establishment or maintenance of bipolar cell polarity GO:0061245 2 0.012
visual behavior GO:0007632 2 0.012
mitotic sister chromatid segregation GO:0000070 53 0.012
regulation of calcium ion transport GO:0051924 79 0.012
protein processing GO:0016485 226 0.012
memory GO:0007613 3 0.012
lipoprotein metabolic process GO:0042157 42 0.012
organic acid biosynthetic process GO:0016053 97 0.012
cellular glucan metabolic process GO:0006073 22 0.012
cellular response to nutrient levels GO:0031669 69 0.012
positive regulation of proteasomal protein catabolic process GO:1901800 35 0.012
negative regulation of proteolysis GO:0045861 132 0.012
somatic stem cell maintenance GO:0035019 4 0.012
axon cargo transport GO:0008088 2 0.012
negative regulation of protein kinase activity GO:0006469 98 0.012
microtubule based process GO:0007017 210 0.012
receptor mediated endocytosis GO:0006898 84 0.012
immune system development GO:0002520 195 0.012
organelle localization GO:0051640 84 0.012
regulation of wnt signaling pathway GO:0030111 123 0.011
glucan metabolic process GO:0044042 22 0.011
negative regulation of cellular protein catabolic process GO:1903363 38 0.011
protein targeting GO:0006605 187 0.011
purine nucleotide catabolic process GO:0006195 405 0.011
fatty acid derivative metabolic process GO:1901568 35 0.011
muscle system process GO:0003012 81 0.011
regulation of protein complex assembly GO:0043254 147 0.011
interspecies interaction between organisms GO:0044419 156 0.011
negative regulation of developmental process GO:0051093 247 0.011
nucleoside triphosphate metabolic process GO:0009141 422 0.011
protein secretion GO:0009306 98 0.011
actin filament organization GO:0007015 128 0.011
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.011
positive regulation of cell death GO:0010942 263 0.011
carboxylic acid biosynthetic process GO:0046394 97 0.011
cell activation GO:0001775 213 0.011
cellular response to abiotic stimulus GO:0071214 117 0.011
sequestering of calcium ion GO:0051208 17 0.011
regulation of transporter activity GO:0032409 82 0.011
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.011
negative regulation of organelle organization GO:0010639 126 0.011
positive regulation of myeloid cell apoptotic process GO:0033034 2 0.011
striated muscle myosin thick filament assembly GO:0071688 2 0.011
positive regulation of secretion GO:0051047 116 0.011
positive regulation of programmed cell death GO:0043068 249 0.011
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.011
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.011
response to lipid GO:0033993 206 0.010
defense response to bacterium GO:0042742 63 0.010
response to virus GO:0009615 126 0.010
nuclear transport GO:0051169 179 0.010
sensory perception of pain GO:0019233 4 0.010
negative regulation of epithelial cell proliferation GO:0050680 48 0.010
rho protein signal transduction GO:0007266 26 0.010
regulation of nucleoside metabolic process GO:0009118 209 0.010
regulation of dephosphorylation GO:0035303 96 0.010
copper ion homeostasis GO:0055070 3 0.010
regulation of immune response GO:0050776 201 0.010
lipoprotein biosynthetic process GO:0042158 33 0.010
single organism membrane organization GO:0044802 268 0.010
cytosolic calcium ion homeostasis GO:0051480 89 0.010
associative learning GO:0008306 1 0.010
response to metal ion GO:0010038 84 0.010
peptidyl serine phosphorylation GO:0018105 101 0.010
rna interference GO:0016246 4 0.010

COPS7A disease predictions

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 155 0.023
endocrine gland cancer DOID:170 26 0.018
organ system cancer DOID:0050686 164 0.018
disease of cellular proliferation DOID:14566 174 0.018
cancer DOID:162 167 0.018
hematopoietic system disease DOID:74 100 0.016
disease of metabolism DOID:0014667 295 0.015
muscle tissue disease DOID:66 113 0.015
muscular disease DOID:0080000 114 0.015
musculoskeletal system disease DOID:17 223 0.015