|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
181 |
1.000
|
Human |
|
|
enzyme linked receptor protein signaling pathway
|
GO:0007167 |
303 |
1.000
|
Human |
|
|
erk1 and erk2 cascade
|
GO:0070371 |
104 |
1.000
|
|
|
|
mapk cascade
|
GO:0000165 |
288 |
0.999
|
Fly |
|
|
regulation of erk1 and erk2 cascade
|
GO:0070372 |
99 |
0.999
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.998
|
|
|
|
regulation of mapk cascade
|
GO:0043408 |
262 |
0.998
|
Fly |
|
|
tyrosine phosphorylation of stat5 protein
|
GO:0042506 |
13 |
0.997
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
289 |
0.993
|
|
|
|
phosphatidylinositol mediated signaling
|
GO:0048015 |
55 |
0.992
|
|
|
|
positive regulation of mapk cascade
|
GO:0043410 |
190 |
0.992
|
Fly |
|
|
positive regulation of phosphatidylinositol 3 kinase signaling
|
GO:0014068 |
28 |
0.991
|
|
|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.990
|
Fly |
|
|
biological adhesion
|
GO:0022610 |
331 |
0.990
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
11 |
0.990
|
|
|
|
ras protein signal transduction
|
GO:0007265 |
73 |
0.985
|
|
|
|
positive regulation of map kinase activity
|
GO:0043406 |
80 |
0.985
|
|
|
|
small gtpase mediated signal transduction
|
GO:0007264 |
78 |
0.983
|
|
|
|
cell development
|
GO:0048468 |
328 |
0.982
|
Fly |
|
|
cellular ketone metabolic process
|
GO:0042180 |
80 |
0.981
|
|
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.981
|
|
|
|
positive regulation of stress activated mapk cascade
|
GO:0032874 |
60 |
0.978
|
Fly |
|
|
positive regulation of protein kinase b signaling
|
GO:0051897 |
42 |
0.978
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.976
|
|
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.973
|
|
|
|
regulation of natural killer cell differentiation
|
GO:0032823 |
2 |
0.971
|
|
|
|
positive regulation of cell proliferation by vegf activated platelet derived growth factor receptor signaling pathway
|
GO:0038091 |
3 |
0.970
|
|
|
|
cell junction organization
|
GO:0034330 |
79 |
0.968
|
|
|
|
negative regulation of programmed cell death
|
GO:0043069 |
321 |
0.965
|
|
|
|
positive regulation of cell proliferation
|
GO:0008284 |
301 |
0.960
|
|
|
|
regulation of map kinase activity
|
GO:0043405 |
108 |
0.951
|
|
|
|
positive regulation of erk1 and erk2 cascade
|
GO:0070374 |
75 |
0.947
|
|
|
|
negative regulation of erk1 and erk2 cascade
|
GO:0070373 |
14 |
0.947
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.946
|
|
|
|
positive regulation of transferase activity
|
GO:0051347 |
227 |
0.942
|
|
|
|
guanosine containing compound metabolic process
|
GO:1901068 |
244 |
0.942
|
Human |
|
|
cellular lipid metabolic process
|
GO:0044255 |
303 |
0.938
|
|
|
|
regulation of interleukin 2 secretion
|
GO:1900040 |
2 |
0.936
|
|
|
|
muscle cell migration
|
GO:0014812 |
19 |
0.932
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.927
|
|
|
|
glial cell migration
|
GO:0008347 |
4 |
0.925
|
|
|
|
regulation of phosphatidylinositol 3 kinase signaling
|
GO:0014066 |
35 |
0.924
|
|
|
|
activation of mapk activity
|
GO:0000187 |
45 |
0.923
|
|
|
|
activation of protein kinase activity
|
GO:0032147 |
90 |
0.920
|
|
|
|
lipid metabolic process
|
GO:0006629 |
381 |
0.918
|
|
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
313 |
0.914
|
|
|
|
cellular response to endogenous stimulus
|
GO:0071495 |
336 |
0.911
|
|
|
|
phospholipid metabolic process
|
GO:0006644 |
99 |
0.903
|
|
|
|
vegf activated platelet derived growth factor receptor signaling pathway
|
GO:0038086 |
3 |
0.902
|
|
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.901
|
|
|
|
regulation of body fluid levels
|
GO:0050878 |
99 |
0.899
|
|
|
|
positive regulation of immune system process
|
GO:0002684 |
283 |
0.897
|
|
|
|
cytokine mediated signaling pathway
|
GO:0019221 |
109 |
0.894
|
|
|
|
protein kinase b signaling
|
GO:0043491 |
69 |
0.893
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
6 |
0.890
|
|
|
|
glycerolipid metabolic process
|
GO:0046486 |
107 |
0.887
|
|
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
190 |
0.887
|
|
|
|
regulation of ras protein signal transduction
|
GO:0046578 |
155 |
0.886
|
Human |
|
|
platelet derived growth factor receptor signaling pathway
|
GO:0048008 |
14 |
0.885
|
|
|
|
phosphatidylinositol metabolic process
|
GO:0046488 |
53 |
0.884
|
|
|
|
regulation of cell migration
|
GO:0030334 |
289 |
0.877
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
41 |
0.870
|
|
|
|
ephrin receptor signaling pathway
|
GO:0048013 |
15 |
0.869
|
Human |
|
|
regulation of lipid metabolic process
|
GO:0019216 |
96 |
0.868
|
|
|
|
positive regulation of lipid kinase activity
|
GO:0090218 |
13 |
0.863
|
|
|
|
leukocyte activation
|
GO:0045321 |
164 |
0.848
|
|
|
|
regulation of purine nucleotide catabolic process
|
GO:0033121 |
205 |
0.846
|
Human |
|
|
cell activation
|
GO:0001775 |
213 |
0.845
|
|
|
|
circulatory system development
|
GO:0072359 |
262 |
0.843
|
Mouse |
|
|
behavior
|
GO:0007610 |
112 |
0.841
|
|
|
|
immune response activating signal transduction
|
GO:0002757 |
90 |
0.840
|
|
|
|
regulation of cell motility
|
GO:2000145 |
299 |
0.837
|
|
|
|
negative regulation of cell proliferation
|
GO:0008285 |
228 |
0.834
|
|
|
|
regulation of nucleotide metabolic process
|
GO:0006140 |
269 |
0.830
|
Human |
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.825
|
|
|
|
peptidyl tyrosine phosphorylation
|
GO:0018108 |
170 |
0.816
|
|
|
|
stress activated protein kinase signaling cascade
|
GO:0031098 |
94 |
0.815
|
Fly |
|
|
positive regulation of endothelial cell migration
|
GO:0010595 |
39 |
0.810
|
|
|
|
cardiovascular system development
|
GO:0072358 |
262 |
0.805
|
Mouse |
|
|
rap protein signal transduction
|
GO:0032486 |
7 |
0.805
|
|
|
|
negative regulation of mapk cascade
|
GO:0043409 |
56 |
0.796
|
|
|
|
single organism cell adhesion
|
GO:0098602 |
179 |
0.788
|
|
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
267 |
0.779
|
|
|
|
epithelial cell migration
|
GO:0010631 |
119 |
0.769
|
Fly |
|
|
cell adhesion
|
GO:0007155 |
325 |
0.767
|
|
|
|
cellular response to nitrogen compound
|
GO:1901699 |
144 |
0.766
|
|
|
|
regulation of neuron differentiation
|
GO:0045664 |
70 |
0.763
|
|
|
|
regulation of protein kinase b signaling
|
GO:0051896 |
61 |
0.762
|
|
|
|
response to oxygen containing compound
|
GO:1901700 |
369 |
0.758
|
|
|
|
phosphatidylinositol 3 kinase signaling
|
GO:0014065 |
48 |
0.754
|
|
|
|
organophosphate catabolic process
|
GO:0046434 |
430 |
0.754
|
Human |
|
|
protein autophosphorylation
|
GO:0046777 |
123 |
0.753
|
|
|
|
system process
|
GO:0003008 |
349 |
0.751
|
|
|
|
female gamete generation
|
GO:0007292 |
2 |
0.751
|
Fly |
|
|
jak stat cascade
|
GO:0007259 |
46 |
0.749
|
|
|
|
regulation of smooth muscle cell migration
|
GO:0014910 |
15 |
0.747
|
|
|
|
antigen receptor mediated signaling pathway
|
GO:0050851 |
38 |
0.747
|
|
|
|
regulation of gtpase activity
|
GO:0043087 |
180 |
0.739
|
Human |
|
|
regulation of purine nucleotide metabolic process
|
GO:1900542 |
264 |
0.734
|
Human |
|
|
oogenesis
|
GO:0048477 |
2 |
0.726
|
Fly |
|
|
positive regulation of kinase activity
|
GO:0033674 |
204 |
0.724
|
|
|
|
response to nitrogen compound
|
GO:1901698 |
184 |
0.723
|
|
|
|
hydrogen peroxide mediated programmed cell death
|
GO:0010421 |
4 |
0.721
|
|
|
|
immune response regulating cell surface receptor signaling pathway
|
GO:0002768 |
51 |
0.720
|
|
|
|
cell projection organization
|
GO:0030030 |
252 |
0.720
|
|
|
|
tor signaling
|
GO:0031929 |
39 |
0.714
|
|
|
|
regulation of metanephric mesenchymal cell migration
|
GO:2000589 |
2 |
0.711
|
|
|
|
actin filament based process
|
GO:0030029 |
224 |
0.707
|
Human Worm |
|
|
immune response regulating signaling pathway
|
GO:0002764 |
97 |
0.687
|
|
|
|
regulation of leukocyte proliferation
|
GO:0070663 |
67 |
0.686
|
|
|
|
focal adhesion assembly
|
GO:0048041 |
30 |
0.685
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
179 |
0.682
|
|
|
|
cellular response to oxygen containing compound
|
GO:1901701 |
276 |
0.682
|
|
|
|
regulation of locomotion
|
GO:0040012 |
329 |
0.681
|
|
|
|
positive regulation of tyrosine phosphorylation of stat5 protein
|
GO:0042523 |
11 |
0.677
|
|
|
|
single organismal cell cell adhesion
|
GO:0016337 |
148 |
0.675
|
|
|
|
positive regulation of metanephric mesenchymal cell migration by platelet derived growth factor receptor beta signaling pathway
|
GO:0035793 |
2 |
0.663
|
|
|
|
vascular endothelial growth factor receptor 1 signaling pathway
|
GO:0036323 |
1 |
0.662
|
|
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
331 |
0.658
|
|
|
|
regulation of metanephric mesenchymal cell migration by platelet derived growth factor receptor beta signaling pathway
|
GO:1900238 |
2 |
0.657
|
|
|
|
negative regulation of protein processing
|
GO:0010955 |
142 |
0.652
|
|
|
|
signal transduction by phosphorylation
|
GO:0023014 |
297 |
0.649
|
Fly |
|
|
negative regulation of phagocytosis
|
GO:0050765 |
4 |
0.646
|
|
|
|
positive regulation of dna replication
|
GO:0045740 |
35 |
0.641
|
|
|
|
regulation of protein processing
|
GO:0070613 |
150 |
0.637
|
|
|
|
tyrosine phosphorylation of stat protein
|
GO:0007260 |
33 |
0.632
|
|
|
|
regulation of actin filament based process
|
GO:0032970 |
141 |
0.627
|
Human |
|
|
regulation of neural precursor cell proliferation
|
GO:2000177 |
4 |
0.626
|
|
|
|
programmed cell death in response to reactive oxygen species
|
GO:0097468 |
4 |
0.624
|
|
|
|
nucleoside phosphate catabolic process
|
GO:1901292 |
412 |
0.618
|
Human |
|
|
regulation of blood circulation
|
GO:1903522 |
59 |
0.616
|
|
|
|
glycosyl compound catabolic process
|
GO:1901658 |
413 |
0.614
|
Human |
|
|
chromatin modification
|
GO:0016568 |
298 |
0.613
|
|
|
|
myoblast fusion
|
GO:0007520 |
1 |
0.612
|
Zebrafish |
|
|
gtp catabolic process
|
GO:0006184 |
237 |
0.603
|
Human |
|
|
platelet derived growth factor receptor beta signaling pathway
|
GO:0035791 |
4 |
0.601
|
|
|
|
positive regulation of rap gtpase activity
|
GO:0032854 |
8 |
0.601
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
183 |
0.599
|
|
|
|
positive regulation of mesenchymal cell proliferation
|
GO:0002053 |
2 |
0.598
|
|
|
|
activated t cell proliferation
|
GO:0050798 |
13 |
0.594
|
|
|
|
positive regulation of phosphatidylinositol 3 kinase activity
|
GO:0043552 |
12 |
0.593
|
|
|
|
regulation of phagocytosis engulfment
|
GO:0060099 |
2 |
0.592
|
|
|
|
renal system development
|
GO:0072001 |
63 |
0.589
|
|
|
|
gtp metabolic process
|
GO:0046039 |
239 |
0.589
|
Human |
|
|
positive regulation of neurogenesis
|
GO:0050769 |
49 |
0.588
|
|
|
|
ameboidal type cell migration
|
GO:0001667 |
135 |
0.588
|
Fly |
|
|
positive regulation of cell development
|
GO:0010720 |
92 |
0.577
|
|
|
|
generation of neurons
|
GO:0048699 |
152 |
0.574
|
|
|
|
protein modification by small protein conjugation
|
GO:0032446 |
342 |
0.572
|
|
|
|
positive regulation of lipid metabolic process
|
GO:0045834 |
50 |
0.568
|
|
|
|
response to purine containing compound
|
GO:0014074 |
40 |
0.563
|
|
|
|
regulation of immune response
|
GO:0050776 |
201 |
0.562
|
|
|
|
response to organic cyclic compound
|
GO:0014070 |
204 |
0.556
|
|
|
|
hematopoietic or lymphoid organ development
|
GO:0048534 |
186 |
0.555
|
Mouse |
|
|
regulation of actin cytoskeleton organization
|
GO:0032956 |
116 |
0.547
|
Human |
|
|
segmentation
|
GO:0035282 |
4 |
0.543
|
|
|
|
positive regulation of protein tyrosine kinase activity
|
GO:0061098 |
24 |
0.535
|
|
|
|
tyrosine phosphorylation of stat3 protein
|
GO:0042503 |
20 |
0.534
|
|
|
|
response to growth factor
|
GO:0070848 |
205 |
0.526
|
|
|
|
mitotic cell cycle
|
GO:0000278 |
326 |
0.519
|
|
|
|
platelet derived growth factor receptor alpha signaling pathway
|
GO:0035790 |
1 |
0.516
|
|
|
|
positive regulation of nucleoside metabolic process
|
GO:0045979 |
186 |
0.515
|
|
|
|
regulation of cell activation
|
GO:0050865 |
125 |
0.513
|
|
|
|
cellular response to hormone stimulus
|
GO:0032870 |
125 |
0.513
|
|
|
|
response to wounding
|
GO:0009611 |
168 |
0.512
|
|
|
|
negative regulation of cell differentiation
|
GO:0045596 |
171 |
0.511
|
|
|
|
male genitalia development
|
GO:0030539 |
1 |
0.509
|
|
|
|
dna integrity checkpoint
|
GO:0031570 |
71 |
0.508
|
|
|
|
regulation of phosphatidylinositol 3 kinase activity
|
GO:0043551 |
14 |
0.502
|
|
|
|
negative regulation of apoptotic signaling pathway
|
GO:2001234 |
97 |
0.496
|
|
|
|
regulation of canonical wnt signaling pathway
|
GO:0060828 |
88 |
0.496
|
|
|
|
cellular response to x ray
|
GO:0071481 |
3 |
0.495
|
|
|
|
regulation of lymphocyte activation
|
GO:0051249 |
103 |
0.492
|
|
|
|
digestive tract development
|
GO:0048565 |
75 |
0.491
|
|
|
|
anatomical structure formation involved in morphogenesis
|
GO:0048646 |
284 |
0.486
|
Zebrafish |
|
|
positive regulation of peptidyl tyrosine phosphorylation
|
GO:0050731 |
85 |
0.484
|
|
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
411 |
0.481
|
Human |
|
|
actin filament organization
|
GO:0007015 |
128 |
0.481
|
|
|
|
natural killer cell differentiation
|
GO:0001779 |
2 |
0.480
|
|
|
|
regulation of non canonical wnt signaling pathway
|
GO:2000050 |
4 |
0.478
|
|
|
|
taurine metabolic process
|
GO:0019530 |
1 |
0.474
|
|
|
|
regulation of hormone levels
|
GO:0010817 |
125 |
0.470
|
|
|
|
negative regulation of map kinase activity
|
GO:0043407 |
27 |
0.468
|
|
|
|
positive regulation of mitotic cell cycle
|
GO:0045931 |
60 |
0.466
|
|
|
|
negative regulation of multicellular organismal process
|
GO:0051241 |
317 |
0.458
|
|
|
|
guanosine containing compound catabolic process
|
GO:1901069 |
239 |
0.454
|
Human |
|
|
regulation of leukocyte activation
|
GO:0002694 |
115 |
0.450
|
|
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.447
|
|
|
|
regulation of cellular response to stress
|
GO:0080135 |
244 |
0.447
|
Fly |
|
|
positive regulation of ras gtpase activity
|
GO:0032320 |
117 |
0.442
|
|
|
|
caveolin mediated endocytosis
|
GO:0072584 |
4 |
0.442
|
|
|
|
angiogenesis involved in wound healing
|
GO:0060055 |
4 |
0.439
|
|
|
|
endothelium development
|
GO:0003158 |
33 |
0.437
|
|
|
|
astrocyte differentiation
|
GO:0048708 |
4 |
0.429
|
|
|
|
prostate gland morphogenesis
|
GO:0060512 |
1 |
0.429
|
|
|
|
glucocorticoid secretion
|
GO:0035933 |
4 |
0.426
|
|
|
|
regulation of mitotic cell cycle
|
GO:0007346 |
189 |
0.425
|
|
|
|
regulation of tyrosine phosphorylation of stat5 protein
|
GO:0042522 |
12 |
0.424
|
|
|
|
regulation of cell morphogenesis
|
GO:0022604 |
153 |
0.420
|
|
|
|
negative regulation of blood coagulation
|
GO:0030195 |
22 |
0.416
|
|
|
|
positive regulation of vasoconstriction
|
GO:0045907 |
3 |
0.405
|
|
|
|
positive regulation of wnt signaling pathway planar cell polarity pathway
|
GO:2000096 |
2 |
0.405
|
|
|
|
neuron projection development
|
GO:0031175 |
106 |
0.402
|
|
|
|
regulation of response to external stimulus
|
GO:0032101 |
222 |
0.398
|
|
|
|
photoreceptor cell differentiation
|
GO:0046530 |
2 |
0.395
|
|
|
|
smooth muscle cell proliferation
|
GO:0048659 |
28 |
0.393
|
|
|
|
cell migration involved in metanephros development
|
GO:0035788 |
2 |
0.393
|
|
|
|
inositol lipid mediated signaling
|
GO:0048017 |
55 |
0.392
|
|
|
|
wnt signaling pathway
|
GO:0016055 |
156 |
0.385
|
|
|
|
regulation of apoptotic cell clearance
|
GO:2000425 |
5 |
0.384
|
|
|
|
positive regulation of cell cycle
|
GO:0045787 |
140 |
0.383
|
|
|
|
positive regulation of metanephric mesenchymal cell migration
|
GO:2000591 |
2 |
0.382
|
|
|
|
regulation of glomerulus development
|
GO:0090192 |
3 |
0.380
|
|
|
|
positive regulation of peptidyl serine phosphorylation
|
GO:0033138 |
42 |
0.378
|
|
|
|
blood circulation
|
GO:0008015 |
113 |
0.375
|
|
|
|
positive regulation of leukocyte proliferation
|
GO:0070665 |
48 |
0.375
|
|
|
|
cell migration involved in kidney development
|
GO:0035787 |
2 |
0.372
|
|
|
|
lymphocyte proliferation
|
GO:0046651 |
70 |
0.372
|
|
|
|
positive regulation of smooth muscle cell migration
|
GO:0014911 |
6 |
0.368
|
|
|
|
negative regulation of wnt signaling pathway
|
GO:0030178 |
69 |
0.367
|
|
|
|
phospholipid biosynthetic process
|
GO:0008654 |
44 |
0.367
|
|
|
|
blastoderm segmentation
|
GO:0007350 |
2 |
0.365
|
|
|
|
positive regulation of calcium ion transport
|
GO:0051928 |
51 |
0.365
|
|
|
|
dna damage checkpoint
|
GO:0000077 |
68 |
0.363
|
|
|
|
regulation of epithelial cell migration
|
GO:0010632 |
93 |
0.360
|
|
|
|
positive regulation of tyrosine phosphorylation of stat protein
|
GO:0042531 |
28 |
0.357
|
|
|
|
regulation of lipid kinase activity
|
GO:0043550 |
19 |
0.357
|
|
|
|
muscle structure development
|
GO:0061061 |
98 |
0.355
|
Zebrafish |
|
|
cellular divalent inorganic cation homeostasis
|
GO:0072503 |
128 |
0.351
|
|
|
|
positive regulation of cytokine mediated signaling pathway
|
GO:0001961 |
12 |
0.351
|
|
|
|
myeloid cell differentiation
|
GO:0030099 |
117 |
0.344
|
|
|
|
positive regulation of neuron projection development
|
GO:0010976 |
34 |
0.343
|
|
|
|
urogenital system development
|
GO:0001655 |
65 |
0.342
|
|
|
|
dna replication
|
GO:0006260 |
116 |
0.340
|
|
|
|
regulation of neuron apoptotic process
|
GO:0043523 |
35 |
0.335
|
|
|
|
somatic stem cell maintenance
|
GO:0035019 |
4 |
0.334
|
|
|
|
ribonucleotide catabolic process
|
GO:0009261 |
405 |
0.334
|
Human |
|
|
vascular wound healing
|
GO:0061042 |
4 |
0.331
|
|
|
|
cellular response to fibroblast growth factor stimulus
|
GO:0044344 |
39 |
0.330
|
|
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
140 |
0.327
|
|
|
|
regulation of nucleotide catabolic process
|
GO:0030811 |
205 |
0.325
|
Human |
|
|
lamellipodium assembly
|
GO:0030032 |
26 |
0.323
|
|
|
|
regulation of stress activated protein kinase signaling cascade
|
GO:0070302 |
85 |
0.322
|
Fly |
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
211 |
0.320
|
|
|
|
defense response
|
GO:0006952 |
315 |
0.319
|
|
|
|
regulation of t cell proliferation
|
GO:0042129 |
42 |
0.319
|
|
|
|
chromatin organization
|
GO:0006325 |
351 |
0.317
|
|
|
|
metanephric mesenchymal cell migration
|
GO:0035789 |
2 |
0.316
|
|
|
|
regulation of stress activated mapk cascade
|
GO:0032872 |
84 |
0.315
|
Fly |
|
|
glycerophospholipid metabolic process
|
GO:0006650 |
84 |
0.315
|
|
|
|
smooth muscle cell migration
|
GO:0014909 |
18 |
0.311
|
|
|
|
positive regulation of tyrosine phosphorylation of stat3 protein
|
GO:0042517 |
16 |
0.311
|
|
|
|
epithelial cell development
|
GO:0002064 |
34 |
0.307
|
Fly |
|
|
positive regulation of stress activated protein kinase signaling cascade
|
GO:0070304 |
61 |
0.305
|
Fly |
|
|
regulation of small gtpase mediated signal transduction
|
GO:0051056 |
156 |
0.304
|
Human |
|
|
regulation of natural killer cell activation
|
GO:0032814 |
9 |
0.303
|
|
|
|
regulation of cell substrate adhesion
|
GO:0010810 |
68 |
0.301
|
|
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
391 |
0.301
|
|
|
|
regulation of defense response
|
GO:0031347 |
154 |
0.301
|
|
|
|
epithelium development
|
GO:0060429 |
227 |
0.301
|
Fly |
|
|
innate immune response
|
GO:0045087 |
178 |
0.300
|
|
|
|
leukocyte differentiation
|
GO:0002521 |
98 |
0.298
|
|
|
|
negative regulation of cellular amine metabolic process
|
GO:0033239 |
3 |
0.298
|
|
|
|
positive regulation of actin filament polymerization
|
GO:0030838 |
38 |
0.292
|
|
|
|
response to radiation
|
GO:0009314 |
151 |
0.285
|
|
|
|
nucleoside catabolic process
|
GO:0009164 |
408 |
0.283
|
Human |
|
|
fibroblast proliferation
|
GO:0048144 |
33 |
0.283
|
|
|
|
long term memory
|
GO:0007616 |
2 |
0.281
|
|
|
|
sex differentiation
|
GO:0007548 |
45 |
0.281
|
|
|
|
positive regulation of protein kinase c signaling
|
GO:0090037 |
5 |
0.281
|
|
|
|
regulation of protein tyrosine kinase activity
|
GO:0061097 |
36 |
0.280
|
|
|
|
regulation of phagocytosis
|
GO:0050764 |
21 |
0.280
|
|
|
|
regulation of tyrosine phosphorylation of stat protein
|
GO:0042509 |
30 |
0.279
|
|
|
|
interleukin 2 secretion
|
GO:0070970 |
3 |
0.275
|
|
|
|
regulation of blood coagulation
|
GO:0030193 |
42 |
0.273
|
|
|
|
stem cell division
|
GO:0017145 |
2 |
0.273
|
|
|
|
regulation of t cell activation
|
GO:0050863 |
77 |
0.272
|
|
|
|
protein localization to organelle
|
GO:0033365 |
280 |
0.271
|
|
|
|
regulation of vesicle mediated transport
|
GO:0060627 |
130 |
0.269
|
|
|
|
neuron apoptotic process
|
GO:0051402 |
39 |
0.269
|
|
|
|
regulation of oxidative stress induced cell death
|
GO:1903201 |
24 |
0.266
|
|
|
|
response to peptide hormone
|
GO:0043434 |
61 |
0.265
|
|
|
|
positive regulation of transport
|
GO:0051050 |
336 |
0.264
|
|
|
|
salivary gland morphogenesis
|
GO:0007435 |
4 |
0.263
|
|
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
379 |
0.260
|
|
|
|
cellular component morphogenesis
|
GO:0032989 |
314 |
0.260
|
|
|
|
regulation of homeostatic process
|
GO:0032844 |
121 |
0.259
|
|
|
|
regulation of jak stat cascade
|
GO:0046425 |
44 |
0.255
|
|
|
|
nervous system development
|
GO:0007399 |
293 |
0.254
|
|
|
|
peptidyl tyrosine modification
|
GO:0018212 |
170 |
0.252
|
|
|
|
regulation of proteolysis
|
GO:0030162 |
293 |
0.251
|
|
|
|
glycerolipid biosynthetic process
|
GO:0045017 |
51 |
0.249
|
|
|
|
positive regulation of defense response
|
GO:0031349 |
87 |
0.243
|
|
|
|
positive regulation of transcription from rna polymerase ii promoter in response to hypoxia
|
GO:0061419 |
2 |
0.242
|
|
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.238
|
|
|
|
peptidyl tyrosine autophosphorylation
|
GO:0038083 |
5 |
0.237
|
|
|
|
purine ribonucleoside catabolic process
|
GO:0046130 |
398 |
0.237
|
Human |
|
|
regulation of cytokine mediated signaling pathway
|
GO:0001959 |
41 |
0.236
|
|
|
|
response to organonitrogen compound
|
GO:0010243 |
156 |
0.235
|
|
|
|
purine nucleoside triphosphate catabolic process
|
GO:0009146 |
392 |
0.235
|
Human |
|
|
vasculature development
|
GO:0001944 |
181 |
0.234
|
Mouse |
|
|
regulation of peptidyl tyrosine phosphorylation
|
GO:0050730 |
108 |
0.234
|
|
|
|
metanephric glomerulus vasculature development
|
GO:0072239 |
1 |
0.233
|
|
|
|
regulation of determination of dorsal identity
|
GO:2000015 |
2 |
0.231
|
|
|
|
engulfment of apoptotic cell
|
GO:0043652 |
2 |
0.230
|
Worm |
|
|
compound eye development
|
GO:0048749 |
1 |
0.230
|
|
|
|
negative regulation of canonical wnt signaling pathway
|
GO:0090090 |
55 |
0.228
|
|
|
|
apoptotic signaling pathway
|
GO:0097190 |
268 |
0.227
|
|
|
|
ribonucleoside triphosphate metabolic process
|
GO:0009199 |
412 |
0.226
|
Human |
|
|
striated muscle cell differentiation
|
GO:0051146 |
43 |
0.226
|
Zebrafish |
|
|
b cell receptor signaling pathway
|
GO:0050853 |
18 |
0.225
|
|
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
175 |
0.222
|
|
|
|
protein ubiquitination
|
GO:0016567 |
314 |
0.218
|
|
|
|
hemopoiesis
|
GO:0030097 |
180 |
0.217
|
|
|
|
growth
|
GO:0040007 |
202 |
0.217
|
|
|
|
activation of jun kinase activity
|
GO:0007257 |
7 |
0.213
|
|
|
|
multicellular organismal response to stress
|
GO:0033555 |
1 |
0.212
|
|
|
|
adherens junction assembly
|
GO:0034333 |
34 |
0.211
|
|
|
|
positive regulation of peptidyl tyrosine autophosphorylation
|
GO:1900086 |
1 |
0.209
|
|
|
|
cellular response to organonitrogen compound
|
GO:0071417 |
124 |
0.208
|
|
|
|
regulation of response to wounding
|
GO:1903034 |
101 |
0.208
|
|
|
|
mast cell degranulation
|
GO:0043303 |
4 |
0.207
|
|
|
|
positive regulation of t cell activation
|
GO:0050870 |
54 |
0.207
|
|
|
|
epithelial cell proliferation
|
GO:0050673 |
128 |
0.207
|
|
|
|
single organism carbohydrate metabolic process
|
GO:0044723 |
193 |
0.205
|
|
|
|
negative regulation of protein serine threonine kinase activity
|
GO:0071901 |
57 |
0.203
|
|
|
|
positive regulation of cellular component organization
|
GO:0051130 |
376 |
0.203
|
|
|
|
hindbrain development
|
GO:0030902 |
3 |
0.203
|
|
|
|
positive regulation of b cell differentiation
|
GO:0045579 |
1 |
0.202
|
|
|
|
positive regulation of jnk cascade
|
GO:0046330 |
52 |
0.201
|
Fly |
|
|
positive regulation of innate immune response
|
GO:0045089 |
79 |
0.200
|
|
|
|
response to drug
|
GO:0042493 |
81 |
0.198
|
|
|
|
astrocyte cell migration
|
GO:0043615 |
1 |
0.198
|
|
|
|
vascular endothelial growth factor receptor signaling pathway
|
GO:0048010 |
19 |
0.198
|
|
|
|
positive regulation of response to external stimulus
|
GO:0032103 |
88 |
0.196
|
|
|
|
regulation of cell adhesion
|
GO:0030155 |
166 |
0.193
|
|
|
|
branched chain amino acid metabolic process
|
GO:0009081 |
4 |
0.193
|
|
|
|
positive regulation of purine nucleotide metabolic process
|
GO:1900544 |
227 |
0.191
|
|
|
|
regulation of wnt signaling pathway
|
GO:0030111 |
123 |
0.190
|
|
|
|
negative regulation of small gtpase mediated signal transduction
|
GO:0051058 |
12 |
0.189
|
|
|
|
cellular response to ionizing radiation
|
GO:0071479 |
32 |
0.189
|
|
|
|
ribonucleoside catabolic process
|
GO:0042454 |
406 |
0.188
|
Human |
|
|
negative regulation of peptidyl tyrosine phosphorylation
|
GO:0050732 |
20 |
0.188
|
|
|
|
purine ribonucleoside metabolic process
|
GO:0046128 |
437 |
0.188
|
Human |
|
|
regulation of ras gtpase activity
|
GO:0032318 |
128 |
0.187
|
Human |
|
|
regulation of fibroblast proliferation
|
GO:0048145 |
32 |
0.187
|
|
|
|
regulation of tyrosine phosphorylation of stat3 protein
|
GO:0042516 |
18 |
0.187
|
|
|
|
activation of transmembrane receptor protein tyrosine kinase activity
|
GO:0007171 |
4 |
0.186
|
|
|
|
ribonucleoside triphosphate catabolic process
|
GO:0009203 |
391 |
0.186
|
Human |
|
|
metanephric nephron development
|
GO:0072210 |
9 |
0.185
|
|
|
|
male sex differentiation
|
GO:0046661 |
25 |
0.185
|
|
|
|
calcium mediated signaling using intracellular calcium source
|
GO:0035584 |
7 |
0.185
|
|
|
|
immune response activating cell surface receptor signaling pathway
|
GO:0002429 |
45 |
0.185
|
|
|
|
inactivation of mapk activity
|
GO:0000188 |
5 |
0.184
|
|
|
|
reactive oxygen species metabolic process
|
GO:0072593 |
75 |
0.183
|
|
|
|
tricarboxylic acid metabolic process
|
GO:0072350 |
4 |
0.183
|
|
|
|
rho protein signal transduction
|
GO:0007266 |
26 |
0.182
|
|
|
|
positive regulation of extracellular matrix organization
|
GO:1903055 |
3 |
0.182
|
|
|
|
positive regulation of jak stat cascade
|
GO:0046427 |
35 |
0.179
|
|
|
|
negative regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043154 |
46 |
0.177
|
|
|
|
collateral sprouting
|
GO:0048668 |
2 |
0.177
|
|
|
|
response to insulin
|
GO:0032868 |
45 |
0.175
|
|
|
|
positive regulation of leukocyte activation
|
GO:0002696 |
80 |
0.175
|
|
|
|
protein processing
|
GO:0016485 |
226 |
0.173
|
|
|
|
immune effector process
|
GO:0002252 |
159 |
0.173
|
|
|
|
regulation of stem cell differentiation
|
GO:2000736 |
56 |
0.172
|
|
|
|
response to oxidative stress
|
GO:0006979 |
121 |
0.172
|
|
|
|
cellular response to hydrogen peroxide
|
GO:0070301 |
37 |
0.172
|
|
|
|
positive regulation of histone deacetylase activity
|
GO:1901727 |
3 |
0.170
|
|
|
|
negative regulation of epidermal growth factor receptor signaling pathway
|
GO:0042059 |
11 |
0.168
|
|
|
|
platelet activation
|
GO:0030168 |
44 |
0.167
|
|
|
|
cellular response to reactive oxygen species
|
GO:0034614 |
50 |
0.167
|
|
|
|
regulation of endocytosis
|
GO:0030100 |
72 |
0.165
|
|
|
|
regulation of system process
|
GO:0044057 |
101 |
0.165
|
|
|
|
neurogenesis
|
GO:0022008 |
169 |
0.164
|
|
|
|
cell matrix adhesion
|
GO:0007160 |
85 |
0.163
|
|
|
|
phosphatidylinositol 3 phosphate biosynthetic process
|
GO:0036092 |
3 |
0.161
|
|
|
|
response to ionizing radiation
|
GO:0010212 |
65 |
0.160
|
|
|
|
response to external biotic stimulus
|
GO:0043207 |
261 |
0.160
|
|
|
|
positive regulation of endothelial cell chemotaxis by vegf activated vascular endothelial growth factor receptor signaling pathway
|
GO:0038033 |
4 |
0.160
|
|
|
|
purine nucleotide catabolic process
|
GO:0006195 |
405 |
0.159
|
Human |
|
|
lipid phosphorylation
|
GO:0046834 |
31 |
0.158
|
|
|
|
purine nucleoside triphosphate metabolic process
|
GO:0009144 |
412 |
0.158
|
Human |
|
|
gland development
|
GO:0048732 |
48 |
0.155
|
Mouse |
|
|
central nervous system neuron axonogenesis
|
GO:0021955 |
3 |
0.153
|
|
|
|
blood vessel development
|
GO:0001568 |
172 |
0.153
|
Mouse |
|
|
regulation of mast cell chemotaxis
|
GO:0060753 |
4 |
0.152
|
|
|
|
neuron development
|
GO:0048666 |
113 |
0.152
|
|
|
|
positive regulation of lipase activity
|
GO:0060193 |
28 |
0.151
|
|
|
|
rac protein signal transduction
|
GO:0016601 |
12 |
0.146
|
|
|
|
positive regulation of cell differentiation
|
GO:0045597 |
211 |
0.146
|
|
|
|
purine nucleoside catabolic process
|
GO:0006152 |
398 |
0.143
|
Human |
|
|
positive regulation of glomerular mesangial cell proliferation
|
GO:0072126 |
1 |
0.141
|
|
|
|
metal ion transport
|
GO:0030001 |
272 |
0.140
|
|
|
|
positive regulation of mononuclear cell proliferation
|
GO:0032946 |
47 |
0.139
|
|
|
|
epithelial cell differentiation
|
GO:0030855 |
141 |
0.137
|
Fly |
|
|
positive regulation of mast cell chemotaxis
|
GO:0060754 |
4 |
0.137
|
|
|
|
cellular metal ion homeostasis
|
GO:0006875 |
146 |
0.137
|
|
|
|
associative learning
|
GO:0008306 |
1 |
0.136
|
|
|
|
nucleoside triphosphate catabolic process
|
GO:0009143 |
394 |
0.136
|
Human |
|
|
negative regulation of kinase activity
|
GO:0033673 |
106 |
0.135
|
|
|
|
granulocyte chemotaxis
|
GO:0071621 |
37 |
0.135
|
|
|
|
neuromuscular junction development
|
GO:0007528 |
3 |
0.135
|
|
|
|
morphogenesis of a branching structure
|
GO:0001763 |
21 |
0.135
|
|
|
|
regulation of cell matrix adhesion
|
GO:0001952 |
42 |
0.134
|
|
|
|
regulation of vascular endothelial growth factor receptor signaling pathway
|
GO:0030947 |
9 |
0.133
|
|
|
|
positive regulation of dna metabolic process
|
GO:0051054 |
73 |
0.132
|
|
|
|
positive regulation of cell activation
|
GO:0050867 |
81 |
0.129
|
|
|
|
positive regulation of secretion by cell
|
GO:1903532 |
108 |
0.128
|
|
|
|
regulation of cellular component movement
|
GO:0051270 |
334 |
0.127
|
|
|
|
regulation of neuron death
|
GO:1901214 |
56 |
0.127
|
|
|
|
regulation of endothelial cell migration
|
GO:0010594 |
67 |
0.126
|
|
|
|
negative regulation of neuron death
|
GO:1901215 |
32 |
0.126
|
|
|
|
positive regulation of t cell proliferation
|
GO:0042102 |
33 |
0.125
|
|
|
|
regulation of endothelial cell proliferation
|
GO:0001936 |
56 |
0.124
|
|
|
|
cellular response to acid chemical
|
GO:0071229 |
44 |
0.124
|
|
|
|
cellular response to starvation
|
GO:0009267 |
58 |
0.123
|
|
|
|
nucleocytoplasmic transport
|
GO:0006913 |
176 |
0.123
|
|
|
|
mononuclear cell proliferation
|
GO:0032943 |
71 |
0.123
|
|
|
|
positive regulation of protein serine threonine kinase activity
|
GO:0071902 |
119 |
0.122
|
|
|
|
post embryonic development
|
GO:0009791 |
2 |
0.121
|
Fly |
|
|
secretion
|
GO:0046903 |
254 |
0.121
|
|
|
|
regulation of endothelial cell apoptotic process
|
GO:2000351 |
24 |
0.121
|
|
|
|
regulation of adherens junction organization
|
GO:1903391 |
21 |
0.121
|
|
|
|
cellular response to nutrient levels
|
GO:0031669 |
69 |
0.120
|
|
|
|
regulation of cytokine production
|
GO:0001817 |
232 |
0.120
|
|
|
|
regulation of cell cycle process
|
GO:0010564 |
266 |
0.120
|
|
|
|
oocyte development
|
GO:0048599 |
1 |
0.120
|
|
|
|
cell death in response to hydrogen peroxide
|
GO:0036474 |
10 |
0.120
|
|
|
|
negative regulation of erythrocyte differentiation
|
GO:0045647 |
3 |
0.120
|
|
|
|
negative regulation of response to external stimulus
|
GO:0032102 |
83 |
0.120
|
|
|
|
hormone metabolic process
|
GO:0042445 |
61 |
0.120
|
|
|
|
protein maturation
|
GO:0051604 |
233 |
0.119
|
|
|
|
regulation of cell junction assembly
|
GO:1901888 |
29 |
0.119
|
|
|
|
interleukin 6 mediated signaling pathway
|
GO:0070102 |
7 |
0.118
|
|
|
|
regulation of peptidase activity
|
GO:0052547 |
180 |
0.118
|
|
|
|
divalent inorganic cation homeostasis
|
GO:0072507 |
136 |
0.118
|
|
|
|
cell division
|
GO:0051301 |
168 |
0.117
|
|
|
|
regulation of receptor mediated endocytosis
|
GO:0048259 |
32 |
0.117
|
|
|
|
blood vessel morphogenesis
|
GO:0048514 |
162 |
0.116
|
|
|
|
myotube differentiation
|
GO:0014902 |
22 |
0.116
|
Zebrafish |
|
|
regulation of cell projection organization
|
GO:0031344 |
107 |
0.116
|
|
|
|
peptidyl serine phosphorylation
|
GO:0018105 |
101 |
0.116
|
|
|
|
negative regulation of protein kinase b signaling
|
GO:0051898 |
17 |
0.115
|
|
|
|
negative regulation of neural precursor cell proliferation
|
GO:2000178 |
1 |
0.115
|
|
|
|
peptidyl serine modification
|
GO:0018209 |
106 |
0.115
|
|
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.115
|
|
|
|
histone modification
|
GO:0016570 |
251 |
0.115
|
|
|
|
negative regulation of endothelial cell apoptotic process
|
GO:2000352 |
16 |
0.114
|
|
|
|
glycerophospholipid biosynthetic process
|
GO:0046474 |
40 |
0.114
|
|
|
|
cellular response to radiation
|
GO:0071478 |
65 |
0.114
|
|
|
|
cellular protein catabolic process
|
GO:0044257 |
261 |
0.113
|
|
|
|
renal system vasculature morphogenesis
|
GO:0061438 |
1 |
0.113
|
|
|
|
regulation of b cell differentiation
|
GO:0045577 |
2 |
0.113
|
|
|
|
digestive system development
|
GO:0055123 |
75 |
0.113
|
|
|
|
positive regulation of cell substrate adhesion
|
GO:0010811 |
37 |
0.112
|
|
|
|
regulation of gtp catabolic process
|
GO:0033124 |
180 |
0.112
|
Human |
|
|
canonical wnt signaling pathway
|
GO:0060070 |
116 |
0.111
|
|
|
|
metencephalon development
|
GO:0022037 |
2 |
0.110
|
|
|
|
positive regulation of endocytosis
|
GO:0045807 |
42 |
0.109
|
|
|
|
regulation of innate immune response
|
GO:0045088 |
97 |
0.108
|
|
|
|
response to inorganic substance
|
GO:0010035 |
127 |
0.108
|
|
|
|
regulation of coagulation
|
GO:0050818 |
44 |
0.107
|
|
|
|
neuron differentiation
|
GO:0030182 |
138 |
0.107
|
|
|
|
luteinization
|
GO:0001553 |
2 |
0.107
|
|
|
|
lamellipodium organization
|
GO:0097581 |
30 |
0.106
|
|
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.106
|
|
|
|
cellular response to biotic stimulus
|
GO:0071216 |
71 |
0.106
|
|
|
|
oocyte differentiation
|
GO:0009994 |
2 |
0.105
|
|
|
|
regulation of cell differentiation
|
GO:0045595 |
393 |
0.104
|
|
|
|
endothelial cell differentiation
|
GO:0045446 |
26 |
0.104
|
|
|
|
positive regulation of epithelial cell migration
|
GO:0010634 |
55 |
0.104
|
|
|
|
branching involved in salivary gland morphogenesis
|
GO:0060445 |
1 |
0.103
|
|
|
|
gliogenesis
|
GO:0042063 |
21 |
0.103
|
|
|
|
positive regulation of behavior
|
GO:0048520 |
60 |
0.103
|
|
|
|
metanephros development
|
GO:0001656 |
16 |
0.102
|
|
|
|
regulation of cell cycle
|
GO:0051726 |
393 |
0.102
|
|
|
|
muscle organ development
|
GO:0007517 |
56 |
0.101
|
|
|
|
nucleoside triphosphate metabolic process
|
GO:0009141 |
422 |
0.101
|
Human |
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
127 |
0.101
|
|
|
|
positive regulation of fibroblast proliferation
|
GO:0048146 |
21 |
0.100
|
|
|
|
calcium ion homeostasis
|
GO:0055074 |
122 |
0.100
|
|
|
|
negative regulation of extrinsic apoptotic signaling pathway
|
GO:2001237 |
52 |
0.100
|
|
|
|
purine ribonucleoside triphosphate catabolic process
|
GO:0009207 |
391 |
0.099
|
Human |
|
|
activation of immune response
|
GO:0002253 |
114 |
0.099
|
|
|
|
calcium ion import
|
GO:0070509 |
23 |
0.098
|
|
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
380 |
0.098
|
|
|
|
regulation of epithelial cell proliferation
|
GO:0050678 |
113 |
0.098
|
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
249 |
0.097
|
|
|
|
regulation of reactive oxygen species metabolic process
|
GO:2000377 |
41 |
0.097
|
|
|
|
mast cell activation involved in immune response
|
GO:0002279 |
4 |
0.097
|
|
|
|
exocytosis
|
GO:0006887 |
71 |
0.097
|
|
|
|
digestive tract morphogenesis
|
GO:0048546 |
56 |
0.096
|
|
|
|
anterior posterior axis specification
|
GO:0009948 |
2 |
0.096
|
|
