Homo sapiens

120 known processes

CTLA4

cytotoxic T-lymphocyte-associated protein 4

(Aliases: ICOS,GRD4,CTLA-4,CELIAC3,CD,CD152,GSE,IDDM12)

CTLA4 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
positive regulation of t cell proliferation GO:0042102 33 0.886
Human
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.834
cytokine biosynthetic process GO:0042089 37 0.818
Human
myeloid dendritic cell differentiation GO:0043011 3 0.806
t cell receptor signaling pathway GO:0050852 21 0.802
positive regulation of lymphocyte proliferation GO:0050671 46 0.802
Human
mononuclear cell proliferation GO:0032943 71 0.788
cellular ketone metabolic process GO:0042180 80 0.773
regulation of cellular amino acid metabolic process GO:0006521 6 0.748
lymphocyte costimulation GO:0031294 7 0.739
t cell costimulation GO:0031295 7 0.713
cytokine secretion GO:0050663 64 0.701
regulation of leukocyte activation GO:0002694 115 0.695
regulation of cellular ketone metabolic process GO:0010565 50 0.688
amine metabolic process GO:0009308 44 0.653
positive regulation of cytokine production GO:0001819 167 0.652
Human
positive regulation of alpha beta t cell proliferation GO:0046641 5 0.637
regulation of mononuclear cell proliferation GO:0032944 65 0.630
t cell proliferation GO:0042098 45 0.614
Human Rat
regulation of cytokine biosynthetic process GO:0042035 35 0.613
Human
t cell activation GO:0042110 99 0.612
lymphocyte mediated immunity GO:0002449 48 0.583
positive regulation of protein secretion GO:0050714 60 0.571
leukocyte activation GO:0045321 164 0.561
regulation of cell activation GO:0050865 125 0.526
immune response GO:0006955 307 0.522
regulation of t cell proliferation GO:0042129 42 0.521
Human Rat
cell activation GO:0001775 213 0.517
positive regulation of lymphocyte activation GO:0051251 73 0.516
Human
positive regulation of mononuclear cell proliferation GO:0032946 47 0.506
Human
regulation of lymphocyte activation GO:0051249 103 0.503
cellular response to metal ion GO:0071248 43 0.503
myeloid dendritic cell activation GO:0001773 4 0.495
positive regulation of secretion by cell GO:1903532 108 0.481
positive regulation of cell proliferation GO:0008284 301 0.470
Human
positive regulation of leukocyte activation GO:0002696 80 0.466
Human
alpha beta t cell proliferation GO:0046633 5 0.462
positive regulation of defense response GO:0031349 87 0.455
immune response regulating cell surface receptor signaling pathway GO:0002768 51 0.454
positive regulation of leukocyte proliferation GO:0070665 48 0.447
Human
lymphocyte proliferation GO:0046651 70 0.446
regulation of protein secretion GO:0050708 86 0.446
lymphocyte activation GO:0046649 133 0.445
positive regulation of immune system process GO:0002684 283 0.443
positive regulation of alpha beta t cell activation GO:0046635 10 0.440
positive regulation of activated t cell proliferation GO:0042104 11 0.435
regulation of leukocyte proliferation GO:0070663 67 0.417
positive regulation of cellular amine metabolic process GO:0033240 7 0.390
regulation of t cell activation GO:0050863 77 0.386
t cell proliferation involved in immune response GO:0002309 1 0.372
leukocyte mediated immunity GO:0002443 59 0.358
activation of innate immune response GO:0002218 55 0.355
regulation of cytokine secretion GO:0050707 57 0.348
regulation of secretion GO:0051046 194 0.337
cellular response to cytokine stimulus GO:0071345 181 0.332
regulation of tolerance induction GO:0002643 4 0.322
leukocyte proliferation GO:0070661 74 0.320
positive regulation of cytokine secretion GO:0050715 42 0.314
positive regulation of interferon gamma biosynthetic process GO:0045078 7 0.312
b cell activation GO:0042113 33 0.306
positive regulation of protein phosphorylation GO:0001934 313 0.305
regulation of t cell tolerance induction GO:0002664 4 0.305
defense response GO:0006952 315 0.299
response to virus GO:0009615 126 0.294
regulation of protein transport GO:0051223 213 0.290
positive regulation of secretion GO:0051047 116 0.279
regulation of establishment of protein localization GO:0070201 242 0.277
regulation of cellular amine metabolic process GO:0033238 11 0.276
adaptive immune response GO:0002250 49 0.276
hematopoietic or lymphoid organ development GO:0048534 186 0.272
positive regulation of immune response GO:0050778 159 0.270
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.261
response to cytokine GO:0034097 232 0.260
positive regulation of t cell activation GO:0050870 54 0.260
Human
response to fungus GO:0009620 4 0.257
positive regulation of phosphorylation GO:0042327 394 0.227
cellular amine metabolic process GO:0044106 41 0.216
positive regulation of transport GO:0051050 336 0.214
regulation of secretion by cell GO:1903530 177 0.213
t cell tolerance induction GO:0002517 4 0.209
cytokine production GO:0001816 247 0.202
Human
positive regulation of interferon gamma production GO:0032729 26 0.199
immune effector process GO:0002252 159 0.199
myeloid cell differentiation GO:0030099 117 0.198
cellular amino acid metabolic process GO:0006520 116 0.193
hemopoiesis GO:0030097 180 0.189
positive regulation of interleukin 10 secretion GO:2001181 2 0.189
negative regulation of developmental process GO:0051093 247 0.187
positive regulation of innate immune response GO:0045089 79 0.181
regulation of protein localization GO:0032880 296 0.178
t cell activation involved in immune response GO:0002286 13 0.175
immune response activating signal transduction GO:0002757 90 0.171
myeloid leukocyte activation GO:0002274 34 0.169
interferon gamma biosynthetic process GO:0042095 8 0.167
regulation of interleukin 10 secretion GO:2001179 4 0.164
regulation of lymphocyte proliferation GO:0050670 64 0.162
interleukin 10 secretion GO:0072608 5 0.160
peptidyl tyrosine modification GO:0018212 170 0.147
negative regulation of immune system process GO:0002683 136 0.145
response to other organism GO:0051707 261 0.137
cytokine mediated signaling pathway GO:0019221 109 0.135
positive regulation of cell activation GO:0050867 81 0.135
Human
negative regulation of cell proliferation GO:0008285 228 0.131
response to external biotic stimulus GO:0043207 261 0.126
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 40 0.126
innate immune response GO:0045087 178 0.122
immune response activating cell surface receptor signaling pathway GO:0002429 45 0.121
positive regulation of apoptotic process GO:0043065 246 0.121
leukocyte activation involved in immune response GO:0002366 30 0.117
regulation of cytokine production GO:0001817 232 0.111
Human
regulation of immune response GO:0050776 201 0.105
response to metal ion GO:0010038 84 0.102
interferon gamma secretion GO:0072643 6 0.099
response to lipopolysaccharide GO:0032496 70 0.097
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 85 0.097
regulation of interferon gamma production GO:0032649 36 0.097
regulation of alpha beta t cell activation GO:0046634 13 0.096
response to biotic stimulus GO:0009607 276 0.086
protein secretion GO:0009306 98 0.085
apoptotic signaling pathway GO:0097190 268 0.084
signal transduction by phosphorylation GO:0023014 297 0.083
regulation of response to external stimulus GO:0032101 222 0.081
peptidyl tyrosine phosphorylation GO:0018108 170 0.080
negative regulation of leukocyte activation GO:0002695 26 0.080
secretion GO:0046903 254 0.079
negative regulation of multicellular organismal process GO:0051241 317 0.077
interferon gamma production GO:0032609 39 0.076
response to molecule of bacterial origin GO:0002237 82 0.075
cytokine metabolic process GO:0042107 38 0.073
Human
response to inorganic substance GO:0010035 127 0.071
regulation of cellular component movement GO:0051270 334 0.071
secretion by cell GO:0032940 226 0.070
regulation of ion transport GO:0043269 189 0.069
immune response regulating signaling pathway GO:0002764 97 0.064
response to bacterium GO:0009617 144 0.063
positive regulation of mapk cascade GO:0043410 190 0.062
lymphocyte apoptotic process GO:0070227 20 0.062
tolerance induction GO:0002507 6 0.060
positive regulation of immunoglobulin mediated immune response GO:0002891 4 0.059
activated t cell proliferation GO:0050798 13 0.057
cellular response to oxygen containing compound GO:1901701 276 0.055
regulation of peptidyl serine phosphorylation of stat protein GO:0033139 3 0.055
cellular response to dna damage stimulus GO:0006974 379 0.054
t cell differentiation in thymus GO:0033077 4 0.054
positive regulation of lymphocyte mediated immunity GO:0002708 23 0.053
positive regulation of astrocyte chemotaxis GO:2000464 1 0.051
calcium ion transport GO:0006816 147 0.051
lipid metabolic process GO:0006629 381 0.050
response to drug GO:0042493 81 0.049
antigen receptor mediated signaling pathway GO:0050851 38 0.049
positive regulation of cytokine biosynthetic process GO:0042108 25 0.048
Human
post embryonic development GO:0009791 2 0.046
regulation of regulatory t cell differentiation GO:0045589 4 0.046
cellular response to biotic stimulus GO:0071216 71 0.045
regulation of activated t cell proliferation GO:0046006 12 0.045
chemical homeostasis GO:0048878 306 0.042
cation homeostasis GO:0055080 189 0.041
cellular chemical homeostasis GO:0055082 180 0.041
determination of adult lifespan GO:0008340 2 0.041
regulation of response to wounding GO:1903034 101 0.040
positive regulation of protein transport GO:0051222 135 0.040
pattern recognition receptor signaling pathway GO:0002221 48 0.040
chemokine c c motif ligand 21 signaling pathway GO:0038116 1 0.039
regulation of cell differentiation GO:0045595 393 0.038
reactive oxygen species biosynthetic process GO:1903409 4 0.038
positive regulation of cell migration GO:0030335 172 0.037
cellular cation homeostasis GO:0030003 163 0.036
positive regulation of hydrolase activity GO:0051345 331 0.036
negative regulation of cell death GO:0060548 345 0.036
positive regulation of kinase activity GO:0033674 204 0.035
alpha beta t cell activation GO:0046631 15 0.035
lymphocyte differentiation GO:0030098 35 0.035
epidermis morphogenesis GO:0048730 3 0.034
locomotory behavior GO:0007626 1 0.034
cell division GO:0051301 168 0.034
Human
positive regulation of cell cycle process GO:0090068 106 0.033
Human
multicellular organismal aging GO:0010259 3 0.033
cellular metal ion homeostasis GO:0006875 146 0.033
epithelial cell proliferation GO:0050673 128 0.033
organophosphate catabolic process GO:0046434 430 0.033
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.033
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.032
regulation of interleukin 10 production GO:0032653 16 0.032
defense response to other organism GO:0098542 129 0.032
regulation of interferon gamma biosynthetic process GO:0045072 8 0.032
ribonucleoside triphosphate metabolic process GO:0009199 412 0.031
regulation of innate immune response GO:0045088 97 0.031
interleukin 8 mediated signaling pathway GO:0038112 2 0.031
chemokine c c motif ligand 19 signaling pathway GO:0038115 1 0.030
viral process GO:0016032 146 0.030
somatic diversification of immunoglobulins involved in immune response GO:0002208 3 0.030
cellular response to endogenous stimulus GO:0071495 336 0.030
positive regulation of cell differentiation GO:0045597 211 0.030
dendritic cell differentiation GO:0097028 13 0.029
interleukin 2 production GO:0032623 20 0.029
Human
regulation of reactive oxygen species metabolic process GO:2000377 41 0.029
regulation of alpha beta t cell proliferation GO:0046640 5 0.028
negative regulation of catalytic activity GO:0043086 335 0.028
lipid biosynthetic process GO:0008610 177 0.028
regulation of cd8 positive alpha beta t cell activation GO:2001185 2 0.028
nucleoside triphosphate metabolic process GO:0009141 422 0.027
leukocyte differentiation GO:0002521 98 0.027
glial cell migration GO:0008347 4 0.027
hair follicle morphogenesis GO:0031069 2 0.027
negative regulation of interleukin 5 production GO:0032714 3 0.027
neuromuscular junction development GO:0007528 3 0.027
protein targeting to nucleus GO:0044744 104 0.027
protein catabolic process GO:0030163 325 0.027
sensory perception of pain GO:0019233 4 0.026
cellular ion homeostasis GO:0006873 168 0.026
regulation of interleukin 2 production GO:0032663 19 0.026
Human
reactive nitrogen species metabolic process GO:2001057 3 0.026
purine nucleoside triphosphate catabolic process GO:0009146 392 0.026
response to lipid GO:0033993 206 0.026
immune system development GO:0002520 195 0.026
protein processing GO:0016485 226 0.026
regulation of protein kinase activity GO:0045859 289 0.025
rho protein signal transduction GO:0007266 26 0.025
biological adhesion GO:0022610 331 0.025
cellular lipid metabolic process GO:0044255 303 0.025
protein import into nucleus GO:0006606 104 0.025
thymic t cell selection GO:0045061 2 0.025
divalent metal ion transport GO:0070838 152 0.025
positive regulation of organelle organization GO:0010638 195 0.025
Human
cellular response to inorganic substance GO:0071241 45 0.025
response to interferon gamma GO:0034341 39 0.025
regulation of ion homeostasis GO:2000021 73 0.024
cell fate determination GO:0001709 3 0.024
purine containing compound catabolic process GO:0072523 411 0.024
establishment of protein localization to organelle GO:0072594 172 0.024
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.024
oogenesis GO:0048477 2 0.024
female gamete generation GO:0007292 2 0.024
regulation of oxidoreductase activity GO:0051341 43 0.024
protein maturation GO:0051604 233 0.023
regulation of cell division GO:0051302 116 0.023
Human
segmentation GO:0035282 4 0.023
positive regulation of cellular catabolic process GO:0031331 284 0.023
positive regulation of erk1 and erk2 cascade GO:0070374 75 0.023
regeneration GO:0031099 4 0.023
stress activated mapk cascade GO:0051403 93 0.023
cytokine production involved in immune response GO:0002367 27 0.023
positive regulation of phosphatidylinositol 3 kinase signaling GO:0014068 28 0.023
regulation of leukocyte differentiation GO:1902105 61 0.023
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.022
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.022
positive regulation of cell cycle GO:0045787 140 0.022
Human
ribonucleoside triphosphate catabolic process GO:0009203 391 0.022
purine ribonucleoside metabolic process GO:0046128 437 0.022
regulation of dna metabolic process GO:0051052 153 0.022
phosphatidylinositol mediated signaling GO:0048015 55 0.022
cellular response to lipid GO:0071396 127 0.022
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.022
positive regulation of peptidyl serine phosphorylation of stat protein GO:0033141 3 0.022
reactive oxygen species metabolic process GO:0072593 75 0.022
aging GO:0007568 66 0.022
regulation of cd4 positive alpha beta t cell proliferation GO:2000561 2 0.021
intracellular protein transport GO:0006886 270 0.021
negative regulation of proteolysis GO:0045861 132 0.021
activation of protein kinase activity GO:0032147 90 0.021
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.021
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.021
protein localization to organelle GO:0033365 280 0.021
protein kinase b signaling GO:0043491 69 0.021
oocyte differentiation GO:0009994 2 0.020
t cell differentiation GO:0030217 29 0.020
adult locomotory behavior GO:0008344 1 0.020
rhythmic behavior GO:0007622 2 0.020
positive regulation of tyrosine phosphorylation of stat3 protein GO:0042517 16 0.020
negative regulation of hydrolase activity GO:0051346 182 0.020
receptor metabolic process GO:0043112 81 0.020
regulation of protein maturation GO:1903317 150 0.020
positive regulation of nucleotide metabolic process GO:0045981 230 0.020
glycosyl compound catabolic process GO:1901658 413 0.020
blastoderm segmentation GO:0007350 2 0.020
eosinophil activation involved in immune response GO:0002278 2 0.019
associative learning GO:0008306 1 0.019
cellular homeostasis GO:0019725 196 0.019
regulation of locomotion GO:0040012 329 0.019
positive regulation of dna metabolic process GO:0051054 73 0.019
negative regulation of cellular protein metabolic process GO:0032269 353 0.019
purine nucleoside catabolic process GO:0006152 398 0.019
positive regulation of adaptive immune response GO:0002821 21 0.019
negative regulation of cellular component organization GO:0051129 235 0.019
vasculature development GO:0001944 181 0.019
protein ubiquitination GO:0016567 314 0.019
nucleoside triphosphate catabolic process GO:0009143 394 0.018
regulation of behavior GO:0050795 82 0.018
natural killer cell mediated cytotoxicity directed against tumor cell target GO:0002420 6 0.018
response to oxygen containing compound GO:1901700 369 0.018
cd4 positive alpha beta t cell differentiation GO:0043367 4 0.018
ribonucleotide catabolic process GO:0009261 405 0.018
purine ribonucleotide catabolic process GO:0009154 404 0.018
nucleotide catabolic process GO:0009166 408 0.018
cellular macromolecule catabolic process GO:0044265 380 0.018
phospholipid metabolic process GO:0006644 99 0.018
cell cell signaling GO:0007267 155 0.018
cell projection organization GO:0030030 252 0.018
cellular calcium ion homeostasis GO:0006874 117 0.018
negative regulation of interleukin 13 secretion GO:2000666 1 0.018
positive regulation of protein kinase b signaling GO:0051897 42 0.017
positive regulation of b cell activation GO:0050871 17 0.017
single organism cellular localization GO:1902580 332 0.017
nucleoside phosphate catabolic process GO:1901292 412 0.017
cellular protein catabolic process GO:0044257 261 0.017
cd4 positive alpha beta t cell differentiation involved in immune response GO:0002294 4 0.017
carboxylic acid biosynthetic process GO:0046394 97 0.017
regulation of system process GO:0044057 101 0.017
regulation of cell cycle GO:0051726 393 0.017
Human
regulation of protein processing GO:0070613 150 0.017
small gtpase mediated signal transduction GO:0007264 78 0.017
somatic recombination of immunoglobulin genes involved in immune response GO:0002204 3 0.017
regulation of small gtpase mediated signal transduction GO:0051056 156 0.017
regulation of b cell proliferation GO:0030888 18 0.017
viral life cycle GO:0019058 132 0.017
regulation of endothelial cell proliferation GO:0001936 56 0.017
b cell receptor signaling pathway GO:0050853 18 0.017
positive regulation of catabolic process GO:0009896 310 0.016
lymphocyte activation involved in immune response GO:0002285 20 0.016
response to tumor necrosis factor GO:0034612 76 0.016
protein targeting GO:0006605 187 0.016
regulation of immune effector process GO:0002697 91 0.016
toll like receptor signaling pathway GO:0002224 25 0.016
regulation of phosphatidylinositol 3 kinase signaling GO:0014066 35 0.016
guanosine containing compound metabolic process GO:1901068 244 0.016
regulation of proteolysis GO:0030162 293 0.016
cytoplasmic transport GO:0016482 379 0.016
dephosphorylation GO:0016311 209 0.016
regulation of anatomical structure morphogenesis GO:0022603 286 0.016
regulation of hormone levels GO:0010817 125 0.016
regulation of cellular response to stress GO:0080135 244 0.016
peptidyl serine phosphorylation GO:0018105 101 0.016
t cell homeostasis GO:0043029 3 0.016
cardiac muscle cell contraction GO:0086003 4 0.016
release of cytoplasmic sequestered nf kappab GO:0008588 4 0.016
purine nucleoside triphosphate metabolic process GO:0009144 412 0.016
erk1 and erk2 cascade GO:0070371 104 0.016
microtubule based process GO:0007017 210 0.016
negative regulation of leukocyte differentiation GO:1902106 24 0.016
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.016
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.016
protein import GO:0017038 130 0.016
negative regulation of protein maturation GO:1903318 142 0.016
response to nitrogen compound GO:1901698 184 0.016
regulation of cellular component biogenesis GO:0044087 281 0.016
actin filament based process GO:0030029 224 0.015
regulation of tyrosine phosphorylation of stat protein GO:0042509 30 0.015
regulation of lipase activity GO:0060191 37 0.015
transmembrane transport GO:0055085 399 0.015
regulation of synaptic plasticity GO:0048167 3 0.015
i kappab kinase nf kappab signaling GO:0007249 166 0.015
nuclear transport GO:0051169 179 0.015
spermatid differentiation GO:0048515 4 0.015
cell activation involved in immune response GO:0002263 30 0.015
regulation of defense response GO:0031347 154 0.015
spermatid development GO:0007286 4 0.015
regulation of nucleotide metabolic process GO:0006140 269 0.015
carbohydrate metabolic process GO:0005975 207 0.015
positive regulation of immunoglobulin production GO:0002639 4 0.015
tissue regeneration GO:0042246 3 0.015
nucleoside catabolic process GO:0009164 408 0.015
negative regulation of phosphorus metabolic process GO:0010563 267 0.015
ribonucleoside catabolic process GO:0042454 406 0.015
protein oligomerization GO:0051259 173 0.015
negative regulation of protein secretion GO:0050709 29 0.015
nervous system development GO:0007399 293 0.015
negative regulation of protein processing GO:0010955 142 0.015
negative regulation of secretion GO:0051048 58 0.015
negative regulation of programmed cell death GO:0043069 321 0.015
mitotic nuclear division GO:0007067 119 0.015
Human
protein modification by small protein conjugation GO:0032446 342 0.015
regulation of calcium ion transport GO:0051924 79 0.015
positive regulation of nucleoside metabolic process GO:0045979 186 0.015
lymphocyte homeostasis GO:0002260 4 0.015
circadian behavior GO:0048512 2 0.015
oxidation reduction process GO:0055114 396 0.015
positive regulation of leukocyte migration GO:0002687 46 0.015
regulation of tyrosine phosphorylation of stat3 protein GO:0042516 18 0.015
angiotensin activated signaling pathway GO:0038166 4 0.015
membrane organization GO:0061024 292 0.014
positive regulation of cell death GO:0010942 263 0.014
nuclear division GO:0000280 128 0.014
Human
monocarboxylic acid metabolic process GO:0032787 185 0.014
mitotic cell cycle GO:0000278 326 0.014
Human
vesicle mediated transport GO:0016192 371 0.014
regulation of leukocyte apoptotic process GO:2000106 25 0.014
regulation of peptidase activity GO:0052547 180 0.014
phagocytosis recognition GO:0006910 3 0.014
taxis GO:0042330 157 0.014
protein acylation GO:0043543 138 0.014
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.014
exocytosis GO:0006887 71 0.014
guanosine containing compound catabolic process GO:1901069 239 0.014
regulation of jak stat cascade GO:0046425 44 0.014
regulation of endopeptidase activity GO:0052548 170 0.014
leukocyte migration GO:0050900 107 0.014
single organism membrane organization GO:0044802 268 0.014
actin filament organization GO:0007015 128 0.014
serotonin transport GO:0006837 3 0.014
regulation of cell migration GO:0030334 289 0.014
oocyte development GO:0048599 1 0.014
inositol lipid mediated signaling GO:0048017 55 0.014
cell morphogenesis GO:0000902 296 0.014
positive regulation of nucleotide catabolic process GO:0030813 185 0.014
positive regulation of jak stat cascade GO:0046427 35 0.014
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.014
regulation of purine nucleotide catabolic process GO:0033121 205 0.014
purinergic nucleotide receptor signaling pathway GO:0035590 4 0.014
regulation of mitotic cell cycle GO:0007346 189 0.014
Human
regulation of sensory perception GO:0051931 3 0.013
nitrogen compound transport GO:0071705 191 0.013
negative regulation of phosphate metabolic process GO:0045936 267 0.013
regulation of inflammatory response GO:0050727 46 0.013
phospholipase c activating g protein coupled receptor signaling pathway GO:0007200 15 0.013
organic acid biosynthetic process GO:0016053 97 0.013
regulation of cytoskeleton organization GO:0051493 177 0.013
negative regulation of cytokine production involved in immune response GO:0002719 13 0.013
positive regulation of lipase activity GO:0060193 28 0.013
covalent chromatin modification GO:0016569 254 0.013
alpha amino acid metabolic process GO:1901605 72 0.013
interleukin 17 production GO:0032620 12 0.013
regulation of mitosis GO:0007088 63 0.013
Human
gtp metabolic process GO:0046039 239 0.013
cell growth GO:0016049 160 0.013
peptidyl lysine modification GO:0018205 144 0.013
organonitrogen compound biosynthetic process GO:1901566 200 0.013
microtubule cytoskeleton organization GO:0000226 176 0.013
neuroblast proliferation GO:0007405 4 0.013
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.013
maintenance of location GO:0051235 112 0.013
limbic system development GO:0021761 3 0.013
regulation of protein catabolic process GO:0042176 155 0.013
organophosphate biosynthetic process GO:0090407 163 0.013
memory GO:0007613 3 0.013
positive regulation of gtp catabolic process GO:0033126 166 0.013
t helper 2 cell cytokine production GO:0035745 3 0.013
circadian sleep wake cycle GO:0042745 2 0.013
purine nucleotide catabolic process GO:0006195 405 0.013
regulation of isotype switching GO:0045191 2 0.013
compound eye development GO:0048749 1 0.013
defense response to bacterium GO:0042742 63 0.012
anterior posterior axis specification GO:0009948 2 0.012
regulation of meiotic cell cycle GO:0051445 4 0.012
negative regulation of response to external stimulus GO:0032102 83 0.012
positive regulation of tyrosine phosphorylation of stat protein GO:0042531 28 0.012
cell cycle phase transition GO:0044770 173 0.012
single organism carbohydrate metabolic process GO:0044723 193 0.012
negative regulation of cellular amine metabolic process GO:0033239 3 0.012
hindbrain development GO:0030902 3 0.012
visual behavior GO:0007632 2 0.012
regulation of astrocyte chemotaxis GO:2000458 1 0.012
negative regulation of intracellular signal transduction GO:1902532 183 0.012
positive regulation of stress activated protein kinase signaling cascade GO:0070304 61 0.012
blood vessel morphogenesis GO:0048514 162 0.012
histone modification GO:0016570 251 0.012
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.012
purine ribonucleoside catabolic process GO:0046130 398 0.012
regulation of erk1 and erk2 cascade GO:0070372 99 0.012
enzyme linked receptor protein signaling pathway GO:0007167 303 0.012
positive regulation of cortisol biosynthetic process GO:2000066 1 0.012
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.012
regulation of peptide transport GO:0090087 62 0.012
ras protein signal transduction GO:0007265 73 0.012
chromatin organization GO:0006325 351 0.012
positive regulation of protein kinase activity GO:0045860 190 0.012
hemostasis GO:0007599 76 0.012
salivary gland morphogenesis GO:0007435 4 0.012
tripartite regional subdivision GO:0007351 2 0.012
interleukin 13 secretion GO:0072611 2 0.012
negative regulation of binding GO:0051100 57 0.012
organelle assembly GO:0070925 176 0.012
regulation of b cell mediated immunity GO:0002712 7 0.012
negative regulation of cellular catabolic process GO:0031330 83 0.012
purine ribonucleotide biosynthetic process GO:0009152 79 0.012
regulation of cell projection organization GO:0031344 107 0.012
phosphatidylinositol 3 kinase signaling GO:0014065 48 0.012
regulation of nucleotide catabolic process GO:0030811 205 0.012
nucleoside phosphate biosynthetic process GO:1901293 109 0.012
regulation of phosphatase activity GO:0010921 81 0.012
keratinization GO:0031424 2 0.012
negative regulation of t helper 2 cell cytokine production GO:2000552 2 0.012

CTLA4 disease predictions

Disease DO term ID Size Probability Func Analog Org
musculoskeletal system disease DOID:17 223 0.037
immune system disease DOID:2914 155 0.025
disease of metabolism DOID:0014667 295 0.021
hematopoietic system disease DOID:74 100 0.021
central nervous system disease DOID:331 186 0.021
nervous system disease DOID:863 431 0.021
cancer DOID:162 167 0.018
disease of cellular proliferation DOID:14566 174 0.018
organ system cancer DOID:0050686 164 0.018
connective tissue disease DOID:65 109 0.016
sensory system disease DOID:0050155 203 0.015
bone disease DOID:0080001 88 0.014
inherited metabolic disorder DOID:655 242 0.013