Homo sapiens

50 known processes

CTSB

cathepsin B

(Aliases: APPS,CPSB)

CTSB biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein maturation GO:0051604 233 0.917
negative regulation of peptidase activity GO:0010466 91 0.908
protein processing GO:0016485 226 0.857
regulation of peptidase activity GO:0052547 180 0.853
regulation of protein processing GO:0070613 150 0.804
peptide cross linking GO:0018149 12 0.773
negative regulation of proteolysis GO:0045861 132 0.772
epithelium development GO:0060429 227 0.712
regulation of blood vessel remodeling GO:0060312 2 0.675
negative regulation of endopeptidase activity GO:0010951 84 0.667
negative regulation of cellular protein metabolic process GO:0032269 353 0.659
epithelial cell differentiation GO:0030855 141 0.653
regulation of mapk cascade GO:0043408 262 0.647
negative regulation of protein maturation GO:1903318 142 0.569
signal transduction by phosphorylation GO:0023014 297 0.566
vasculature development GO:0001944 181 0.546
negative regulation of catalytic activity GO:0043086 335 0.541
negative regulation of hydrolase activity GO:0051346 182 0.456
secretion by cell GO:0032940 226 0.455
negative regulation of elastin catabolic process GO:0060311 1 0.421
g protein coupled receptor signaling pathway GO:0007186 207 0.417
negative regulation of protein metabolic process GO:0051248 391 0.398
negative regulation of multicellular organismal process GO:0051241 317 0.391
epidermal cell differentiation GO:0009913 45 0.340
regulation of cellular ketone metabolic process GO:0010565 50 0.327
regulation of endopeptidase activity GO:0052548 170 0.317
cellular response to endogenous stimulus GO:0071495 336 0.307
keratinocyte differentiation GO:0030216 36 0.278
response to thyroid hormone GO:0097066 9 0.270
circulatory system development GO:0072359 262 0.264
blood vessel morphogenesis GO:0048514 162 0.263
extracellular matrix organization GO:0030198 41 0.261
response to hormone GO:0009725 175 0.246
negative regulation of protein processing GO:0010955 142 0.237
nervous system development GO:0007399 293 0.236
negative regulation of locomotion GO:0040013 118 0.235
protein heterotetramerization GO:0051290 3 0.232
chemical homeostasis GO:0048878 306 0.225
regulation of protein maturation GO:1903317 150 0.213
negative regulation of phospholipase activity GO:0010519 3 0.208
gtp metabolic process GO:0046039 239 0.205
system process GO:0003008 349 0.202
defense response GO:0006952 315 0.181
Worm
response to xenobiotic stimulus GO:0009410 30 0.179
regulation of secretion GO:0051046 194 0.176
mapk cascade GO:0000165 288 0.176
regulation of vasculature development GO:1901342 97 0.169
biological adhesion GO:0022610 331 0.159
cytokine production GO:0001816 247 0.159
negative regulation of cell motility GO:2000146 104 0.158
single organismal cell cell adhesion GO:0016337 148 0.151
regulation of proteolysis GO:0030162 293 0.150
negative regulation of multicellular organismal metabolic process GO:0044252 3 0.148
skin development GO:0043588 76 0.146
regulation of integrin mediated signaling pathway GO:2001044 3 0.146
sterol transport GO:0015918 39 0.145
regulation of gtp catabolic process GO:0033124 180 0.140
regulation of cell adhesion GO:0030155 166 0.138
secretion GO:0046903 254 0.135
regulation of cell migration GO:0030334 289 0.135
small gtpase mediated signal transduction GO:0007264 78 0.134
regulation of elastin catabolic process GO:0060310 1 0.132
immune response GO:0006955 307 0.132
Worm
anatomical structure formation involved in morphogenesis GO:0048646 284 0.130
anatomical structure homeostasis GO:0060249 100 0.129
metal ion homeostasis GO:0055065 169 0.128
angiogenesis GO:0001525 147 0.126
cell adhesion GO:0007155 325 0.126
positive regulation of programmed cell death GO:0043068 249 0.125
blood vessel development GO:0001568 172 0.121
basement membrane organization GO:0071711 3 0.119
negative regulation of programmed cell death GO:0043069 321 0.115
membrane raft assembly GO:0001765 7 0.115
guanosine containing compound metabolic process GO:1901068 244 0.114
carbohydrate metabolic process GO:0005975 207 0.111
regulation of rubidium ion transport GO:2000680 3 0.111
central nervous system development GO:0007417 123 0.111
regulation of angiogenesis GO:0045765 92 0.109
regulation of anatomical structure morphogenesis GO:0022603 286 0.108
vasodilation GO:0042311 4 0.108
rho protein signal transduction GO:0007266 26 0.108
cellular response to hormone stimulus GO:0032870 125 0.106
negative regulation of cellular component movement GO:0051271 106 0.105
purine ribonucleoside metabolic process GO:0046128 437 0.105
negative regulation of cell proliferation GO:0008285 228 0.105
regulation of purine nucleotide metabolic process GO:1900542 264 0.104
enzyme linked receptor protein signaling pathway GO:0007167 303 0.103
sensory perception of chemical stimulus GO:0007606 38 0.102
negative regulation of collagen catabolic process GO:0010711 1 0.100
regulation of cellular response to growth factor stimulus GO:0090287 76 0.100
purine nucleoside catabolic process GO:0006152 398 0.098
regulation of cell motility GO:2000145 299 0.096
ribonucleoside catabolic process GO:0042454 406 0.096
fibroblast proliferation GO:0048144 33 0.095
regulation of gtpase activity GO:0043087 180 0.094
response to wounding GO:0009611 168 0.093
Zebrafish Rat
single organism carbohydrate metabolic process GO:0044723 193 0.093
protein localization to membrane GO:0072657 160 0.093
regulation of purine nucleotide catabolic process GO:0033121 205 0.093
multicellular organismal homeostasis GO:0048871 67 0.092
single organism reproductive process GO:0044702 98 0.091
Mouse Rat
lipid metabolic process GO:0006629 381 0.090
epidermis development GO:0008544 59 0.088
regulation of nucleotide catabolic process GO:0030811 205 0.087
sulfur compound metabolic process GO:0006790 101 0.087
regulation of cellular amino acid metabolic process GO:0006521 6 0.087
negative regulation of metalloenzyme activity GO:0048553 1 0.085
organic hydroxy compound transport GO:0015850 63 0.084
response to growth factor GO:0070848 205 0.084
multicellular organismal macromolecule metabolic process GO:0044259 29 0.084
negative regulation of apoptotic process GO:0043066 316 0.082
nucleoside phosphate catabolic process GO:1901292 412 0.081
positive regulation of protein phosphorylation GO:0001934 313 0.081
ras protein signal transduction GO:0007265 73 0.078
cardiovascular system development GO:0072358 262 0.077
gtp catabolic process GO:0006184 237 0.077
regulation of cytokine production GO:0001817 232 0.076
ribonucleotide catabolic process GO:0009261 405 0.076
positive regulation of angiogenesis GO:0045766 51 0.075
positive regulation of cytoskeleton organization GO:0051495 83 0.075
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.074
purine containing compound catabolic process GO:0072523 411 0.074
inflammatory response GO:0006954 79 0.073
positive regulation of cellular component organization GO:0051130 376 0.072
negative regulation of cell migration GO:0030336 102 0.072
gland development GO:0048732 48 0.072
reproductive process GO:0022414 106 0.072
Mouse Rat
neurological system process GO:0050877 163 0.069
cellular macromolecule catabolic process GO:0044265 380 0.068
regulation of cellular component movement GO:0051270 334 0.068
ribonucleoside triphosphate catabolic process GO:0009203 391 0.066
i kappab kinase nf kappab signaling GO:0007249 166 0.064
regulation of systemic arterial blood pressure by circulatory renin angiotensin GO:0001991 4 0.064
negative regulation of glycoprotein metabolic process GO:1903019 8 0.064
positive regulation of gtpase activity GO:0043547 166 0.064
negative regulation of phosphorylation GO:0042326 174 0.063
cation transmembrane transport GO:0098655 238 0.063
antigen processing and presentation GO:0019882 33 0.063
cell morphogenesis GO:0000902 296 0.063
cellular ketone metabolic process GO:0042180 80 0.062
regulation of hormone levels GO:0010817 125 0.061
regulation of response to wounding GO:1903034 101 0.061
inorganic ion transmembrane transport GO:0098660 231 0.059
regulation of nucleotide metabolic process GO:0006140 269 0.059
regulation of transferase activity GO:0051338 355 0.058
neuromuscular process GO:0050905 15 0.056
negative regulation of blood vessel remodeling GO:0060313 1 0.056
membrane lipid metabolic process GO:0006643 53 0.056
positive regulation of phosphorylation GO:0042327 394 0.055
regulation of apoptotic signaling pathway GO:2001233 175 0.054
positive regulation of nucleoside metabolic process GO:0045979 186 0.054
negative regulation of cellular catabolic process GO:0031330 83 0.053
response to inorganic substance GO:0010035 127 0.053
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.052
apoptotic signaling pathway GO:0097190 268 0.052
negative regulation of serine type peptidase activity GO:1902572 2 0.052
positive regulation of epithelial cell proliferation GO:0050679 65 0.050
regulation of rho gtpase activity GO:0032319 66 0.050
nucleoside catabolic process GO:0009164 408 0.050
extracellular matrix disassembly GO:0022617 16 0.049
positive regulation of cell death GO:0010942 263 0.049
regulation of cell differentiation GO:0045595 393 0.049
negative regulation of protein serine threonine kinase activity GO:0071901 57 0.049
female gamete generation GO:0007292 2 0.049
purine ribonucleoside catabolic process GO:0046130 398 0.049
cellular ion homeostasis GO:0006873 168 0.048
single organism cell adhesion GO:0098602 179 0.047
amino sugar metabolic process GO:0006040 15 0.047
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.047
behavior GO:0007610 112 0.047
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.047
exocytosis GO:0006887 71 0.046
microtubule based process GO:0007017 210 0.046
negative regulation of protein phosphorylation GO:0001933 140 0.046
nucleoside triphosphate metabolic process GO:0009141 422 0.045
response to metal ion GO:0010038 84 0.045
regulation of blood coagulation GO:0030193 42 0.044
positive regulation of cellular amine metabolic process GO:0033240 7 0.044
regulation of binding GO:0051098 111 0.043
neurogenesis GO:0022008 169 0.042
nucleoside triphosphate catabolic process GO:0009143 394 0.042
negative regulation of phosphate metabolic process GO:0045936 267 0.042
response to nutrient levels GO:0031667 81 0.042
regulation of vesicle mediated transport GO:0060627 130 0.042
positive regulation of ras gtpase activity GO:0032320 117 0.040
regulation of protein serine threonine kinase activity GO:0071900 179 0.040
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.039
regulation of kinase activity GO:0043549 314 0.039
ion homeostasis GO:0050801 230 0.039
regulation of defense response GO:0031347 154 0.038
ribonucleoside triphosphate metabolic process GO:0009199 412 0.038
locomotory behavior GO:0007626 1 0.038
negative regulation of intracellular signal transduction GO:1902532 183 0.038
extracellular structure organization GO:0043062 41 0.038
cellular response to growth factor stimulus GO:0071363 197 0.036
negative regulation of transferase activity GO:0051348 124 0.036
negative regulation of catabolic process GO:0009895 104 0.036
sensory perception GO:0007600 103 0.036
determination of adult lifespan GO:0008340 2 0.036
Worm
positive regulation of apoptotic signaling pathway GO:2001235 70 0.035
nucleotide catabolic process GO:0009166 408 0.035
negative regulation of immune system process GO:0002683 136 0.035
ganglioside metabolic process GO:0001573 7 0.035
collagen catabolic process GO:0030574 10 0.035
cellular amino acid metabolic process GO:0006520 116 0.034
negative regulation of camp mediated signaling GO:0043951 4 0.034
organophosphate catabolic process GO:0046434 430 0.034
response to reactive oxygen species GO:0000302 61 0.034
negative regulation of cell death GO:0060548 345 0.034
Rat
growth GO:0040007 202 0.033
Zebrafish
cellular amine metabolic process GO:0044106 41 0.033
protein activation cascade GO:0072376 22 0.033
cellular response to hydrogen peroxide GO:0070301 37 0.033
positive regulation of secretion GO:0051047 116 0.033
calcium ion transport GO:0006816 147 0.033
positive regulation of organelle organization GO:0010638 195 0.033
sensory perception of bitter taste GO:0050913 28 0.032
adult locomotory behavior GO:0008344 1 0.032
regulation of vascular endothelial growth factor signaling pathway GO:1900746 6 0.032
endocytosis GO:0006897 159 0.032
Worm
endomembrane system organization GO:0010256 196 0.032
single organism carbohydrate catabolic process GO:0044724 33 0.031
rubidium ion transport GO:0035826 4 0.031
positive regulation of cell motility GO:2000147 177 0.031
sensory perception of taste GO:0050909 36 0.030
positive regulation of catabolic process GO:0009896 310 0.030
positive regulation of transport GO:0051050 336 0.030
detection of chemical stimulus GO:0009593 55 0.030
cellular metal ion homeostasis GO:0006875 146 0.030
regulation of response to external stimulus GO:0032101 222 0.030
regulation of systemic arterial blood pressure by hormone GO:0001990 12 0.030
cellular response to oxygen containing compound GO:1901701 276 0.030
negative regulation of trophoblast cell migration GO:1901164 3 0.029
plasma membrane organization GO:0007009 115 0.029
negative regulation of developmental process GO:0051093 247 0.029
response to tumor necrosis factor GO:0034612 76 0.029
regulation of cellular component biogenesis GO:0044087 281 0.029
monovalent inorganic cation transport GO:0015672 128 0.029
positive regulation of gtp catabolic process GO:0033126 166 0.029
regulation of locomotion GO:0040012 329 0.029
glycoprotein metabolic process GO:0009100 110 0.029
cell development GO:0048468 328 0.029
regulation of protein secretion GO:0050708 86 0.028
regulation of phospholipase activity GO:0010517 26 0.028
purine ribonucleotide catabolic process GO:0009154 404 0.028
cytoplasmic transport GO:0016482 379 0.028
regulation of fibroblast proliferation GO:0048145 32 0.028
response to other organism GO:0051707 261 0.028
regulation of cellular amine metabolic process GO:0033238 11 0.028
regulation of tube size GO:0035150 18 0.028
tissue migration GO:0090130 119 0.028
neutrophil aggregation GO:0070488 2 0.028
regulation of ras protein signal transduction GO:0046578 155 0.028
monocarboxylic acid metabolic process GO:0032787 185 0.028
positive regulation of cell proliferation GO:0008284 301 0.027
xenobiotic metabolic process GO:0006805 28 0.027
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.027
mating GO:0007618 1 0.027
purine nucleoside triphosphate catabolic process GO:0009146 392 0.027
microtubule cytoskeleton organization GO:0000226 176 0.026
head development GO:0060322 108 0.026
regulation of anatomical structure size GO:0090066 101 0.026
cellular response to extracellular stimulus GO:0031668 72 0.026
positive regulation of cellular catabolic process GO:0031331 284 0.026
epithelium migration GO:0090132 119 0.026
cellular cation homeostasis GO:0030003 163 0.026
response to organonitrogen compound GO:0010243 156 0.026
Rat
post embryonic development GO:0009791 2 0.026
Worm
cellular amide metabolic process GO:0043603 69 0.025
positive regulation of striated muscle contraction GO:0045989 1 0.025
cellular response to lipid GO:0071396 127 0.025
endothelial cell migration GO:0043542 86 0.025
amine metabolic process GO:0009308 44 0.025
response to fungus GO:0009620 4 0.025
negative regulation of protein transport GO:0051224 75 0.025
cell matrix adhesion GO:0007160 85 0.025
negative regulation of mapk cascade GO:0043409 56 0.025
cellular response to oxidative stress GO:0034599 85 0.025
regulation of secretion by cell GO:1903530 177 0.024
arachidonic acid metabolic process GO:0019369 14 0.024
cellular response to external stimulus GO:0071496 111 0.024
Rat
regulation of ion transport GO:0043269 189 0.024
negative regulation of cellular component organization GO:0051129 235 0.024
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.024
hematopoietic or lymphoid organ development GO:0048534 186 0.024
regulation of phospholipase a2 activity GO:0032429 4 0.024
regulation of inflammatory response GO:0050727 46 0.023
positive regulation of rho gtpase activity GO:0032321 56 0.023
protein tetramerization GO:0051262 47 0.023
ion transmembrane transport GO:0034220 338 0.023
response to axon injury GO:0048678 1 0.023
membrane organization GO:0061024 292 0.022
regulation of collagen catabolic process GO:0010710 3 0.022
regulation of angiotensin levels in blood GO:0002002 3 0.022
regulation of rho protein signal transduction GO:0035023 79 0.022
positive regulation of developmental process GO:0051094 314 0.022
regulation of protein kinase activity GO:0045859 289 0.022
positive regulation of apoptotic process GO:0043065 246 0.022
cellular chemical homeostasis GO:0055082 180 0.022
ameboidal type cell migration GO:0001667 135 0.022
regulation of adrenergic receptor signaling pathway GO:0071877 1 0.022
negative regulation of fibroblast growth factor receptor signaling pathway GO:0040037 2 0.021
leukocyte differentiation GO:0002521 98 0.021
protein catabolic process GO:0030163 325 0.021
single organism membrane organization GO:0044802 268 0.021
cellular response to reactive oxygen species GO:0034614 50 0.021
regulation of establishment of protein localization GO:0070201 242 0.021
negative regulation of interleukin 8 secretion GO:2000483 2 0.021
regulation of epithelial cell proliferation GO:0050678 113 0.021
midbrain development GO:0030901 45 0.021
regulation of protein localization GO:0032880 296 0.021
peptide metabolic process GO:0006518 51 0.021
cell growth GO:0016049 160 0.021
cellular response to decreased oxygen levels GO:0036294 51 0.020
regulation of cellular response to stress GO:0080135 244 0.020
negative regulation of blood vessel morphogenesis GO:2000181 41 0.020
fibroblast growth factor receptor signaling pathway GO:0008543 26 0.020
guanosine containing compound catabolic process GO:1901069 239 0.020
epithelial cell proliferation GO:0050673 128 0.020
vascular process in circulatory system GO:0003018 29 0.020
positive regulation of protein kinase activity GO:0045860 190 0.020
hemopoiesis GO:0030097 180 0.020
dna replication GO:0006260 116 0.020
negative regulation of protein modification process GO:0031400 200 0.020
response to extracellular stimulus GO:0009991 85 0.020
response to oxidative stress GO:0006979 121 0.020
regulation of small gtpase mediated signal transduction GO:0051056 156 0.020
lipid localization GO:0010876 106 0.020
osteoclast development GO:0036035 2 0.020
zymogen activation GO:0031638 70 0.019
monocarboxylic acid biosynthetic process GO:0072330 67 0.019
adaptive immune response GO:0002250 49 0.019
purine nucleoside triphosphate metabolic process GO:0009144 412 0.019
cytokine secretion GO:0050663 64 0.019
cellular component morphogenesis GO:0032989 314 0.019
negative regulation of oxidative stress induced cell death GO:1903202 17 0.019
cellular lipid metabolic process GO:0044255 303 0.019
regulation of protein catabolic process GO:0042176 155 0.019
cellular response to glucocorticoid stimulus GO:0071385 4 0.019
neuromuscular process controlling balance GO:0050885 7 0.019
regulation of metalloenzyme activity GO:0048552 3 0.019
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.019
glycoprotein biosynthetic process GO:0009101 91 0.019
receptor metabolic process GO:0043112 81 0.018
transmembrane transport GO:0055085 399 0.018
metal ion transport GO:0030001 272 0.018
retina development in camera type eye GO:0060041 15 0.018
multi organism reproductive process GO:0044703 54 0.018
Mouse Rat
tissue homeostasis GO:0001894 63 0.018
aging GO:0007568 66 0.018
Worm
regulation of lipase activity GO:0060191 37 0.018
response to calcium ion GO:0051592 46 0.018
single organism cellular localization GO:1902580 332 0.018
maintenance of location GO:0051235 112 0.017
divalent metal ion transport GO:0070838 152 0.017
wnt signaling pathway GO:0016055 156 0.017
response to drug GO:0042493 81 0.017
cellular divalent inorganic cation homeostasis GO:0072503 128 0.017
negative regulation of phosphorus metabolic process GO:0010563 267 0.017
neutrophil homeostasis GO:0001780 3 0.017
response to hydrogen peroxide GO:0042542 40 0.017
glycoprotein catabolic process GO:0006516 7 0.016
mitotic cell cycle GO:0000278 326 0.016
cellular lipid catabolic process GO:0044242 65 0.016
cation transport GO:0006812 331 0.016
ganglioside catabolic process GO:0006689 3 0.016
negative regulation of cellular amine metabolic process GO:0033239 3 0.016
regulation of cytokine secretion GO:0050707 57 0.016
intracellular protein transport GO:0006886 270 0.016
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.016
purine nucleotide catabolic process GO:0006195 405 0.016
relaxation of cardiac muscle GO:0055119 5 0.016
response to estradiol GO:0032355 23 0.015
negative regulation of protein kinase activity GO:0006469 98 0.015
positive regulation of nucleotide catabolic process GO:0030813 185 0.015
response to organic cyclic compound GO:0014070 204 0.015
Rat
negative regulation of muscle contraction GO:0045932 3 0.015
membrane protein proteolysis GO:0033619 38 0.015
lipid biosynthetic process GO:0008610 177 0.015
leukocyte migration GO:0050900 107 0.015
response to starvation GO:0042594 59 0.015
developmental process involved in reproduction GO:0003006 66 0.015
Mouse
negative regulation of serine type endopeptidase activity GO:1900004 2 0.015
regulation of ras gtpase activity GO:0032318 128 0.015
carboxylic acid biosynthetic process GO:0046394 97 0.015
positive regulation of t cell tolerance induction GO:0002666 2 0.014
positive regulation of intrinsic apoptotic signaling pathway GO:2001244 28 0.014
sphingolipid metabolic process GO:0006665 38 0.014
protein secretion GO:0009306 98 0.014
positive regulation of kinase activity GO:0033674 204 0.014
aminoglycan metabolic process GO:0006022 39 0.014
response to radiation GO:0009314 151 0.014
cellular response to organic cyclic compound GO:0071407 127 0.014
response to estrogen GO:0043627 47 0.014
cellular protein complex assembly GO:0043623 188 0.014
positive regulation of nucleotide metabolic process GO:0045981 230 0.014
cellular response to thyroid hormone stimulus GO:0097067 9 0.014
regulation of system process GO:0044057 101 0.014
regulation of actin filament bundle assembly GO:0032231 36 0.014
retina homeostasis GO:0001895 42 0.014
response to external biotic stimulus GO:0043207 261 0.014
transition metal ion homeostasis GO:0055076 31 0.014
response to cytokine GO:0034097 232 0.014
Rat
skeletal system development GO:0001501 79 0.014
positive regulation of fibroblast proliferation GO:0048146 21 0.014
transition metal ion transport GO:0000041 23 0.014
negative regulation of cell differentiation GO:0045596 171 0.014
positive regulation of cellular component biogenesis GO:0044089 158 0.013
negative regulation of protein activation cascade GO:2000258 7 0.013
protein localization to organelle GO:0033365 280 0.013
protein oligomerization GO:0051259 173 0.013
cellular response to nutrient levels GO:0031669 69 0.013
leukocyte mediated immunity GO:0002443 59 0.013
blastocyst development GO:0001824 3 0.013
cellular response to tumor necrosis factor GO:0071356 63 0.013
negative regulation of angiogenesis GO:0016525 39 0.013
sterol homeostasis GO:0055092 28 0.013
prostate gland development GO:0030850 3 0.013
cell death in response to oxidative stress GO:0036473 29 0.013
cell projection assembly GO:0030031 126 0.013
regulation of exocytosis GO:0017157 46 0.013
negative regulation of leukocyte differentiation GO:1902106 24 0.013
reproductive structure development GO:0048608 55 0.013
Mouse
glycosaminoglycan metabolic process GO:0030203 35 0.013
response to steroid hormone GO:0048545 80 0.013
regulation of serine type peptidase activity GO:1902571 2 0.013
positive regulation of rac gtpase activity GO:0032855 31 0.013
circulatory system process GO:0003013 113 0.013
tissue morphogenesis GO:0048729 96 0.013
regulation of cell matrix adhesion GO:0001952 42 0.013
negative regulation of vasculature development GO:1901343 43 0.013
peptide catabolic process GO:0043171 10 0.013
response to lipid GO:0033993 206 0.013
positive regulation of vesicle fusion GO:0031340 4 0.013
substantia nigra development GO:0021762 45 0.013
response to oxygen levels GO:0070482 100 0.013
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 49 0.013
oogenesis GO:0048477 2 0.013
regulation of serine type endopeptidase activity GO:1900003 2 0.013
positive regulation of binding GO:0051099 45 0.013
negative regulation of cellular response to oxidative stress GO:1900408 18 0.013
myeloid cell differentiation GO:0030099 117 0.013
regulation of growth GO:0040008 165 0.012
regulation of g protein coupled receptor protein signaling pathway GO:0008277 35 0.012
brain development GO:0007420 97 0.012
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 43 0.012
positive regulation of cell differentiation GO:0045597 211 0.012
multi multicellular organism process GO:0044706 18 0.012
Mouse
positive regulation of cell development GO:0010720 92 0.012
epithelial cell migration GO:0010631 119 0.012
sequestering of metal ion GO:0051238 24 0.012
oxidation reduction process GO:0055114 396 0.012
intestinal absorption GO:0050892 4 0.012
cellular response to oxygen levels GO:0071453 55 0.012
regulation of blood vessel size GO:0050880 18 0.012
activation of cysteine type endopeptidase activity GO:0097202 57 0.012
response to bacterium GO:0009617 144 0.012
negative regulation of apoptotic signaling pathway GO:2001234 97 0.012
peptidyl tyrosine modification GO:0018212 170 0.012
regulation of nucleoside metabolic process GO:0009118 209 0.012
regulation of cell junction assembly GO:1901888 29 0.011
lipid transport GO:0006869 90 0.011
detection of stimulus GO:0051606 85 0.011
monosaccharide metabolic process GO:0005996 74 0.011
vesicle mediated transport GO:0016192 371 0.011
Worm
negative regulation of cellular response to growth factor stimulus GO:0090288 41 0.011
regulation of lymphocyte activation GO:0051249 103 0.011
antigen processing and presentation of peptide antigen GO:0048002 18 0.011
inorganic cation transmembrane transport GO:0098662 194 0.011

CTSB disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.996
inherited metabolic disorder DOID:655 242 0.996
lysosomal storage disease DOID:3211 47 0.994
lipid storage disease DOID:9455 28 0.838
central nervous system disease DOID:331 186 0.550
nervous system disease DOID:863 431 0.550
epilepsy syndrome DOID:1826 41 0.287
brain disease DOID:936 73 0.287
variable age at onset electroclinical syndrome DOID:0050706 8 0.287
electroclinical syndrome DOID:0050701 32 0.287
progressive myoclonus epilepsy DOID:891 8 0.180
cerebral degeneration DOID:1443 16 0.134
sensory system disease DOID:0050155 203 0.054
eye and adnexa disease DOID:1492 150 0.054
eye disease DOID:5614 149 0.054
retinal disease DOID:5679 118 0.052
sphingolipidosis DOID:1927 14 0.040
neuronal ceroid lipofuscinosis DOID:14503 11 0.030
neurodegenerative disease DOID:1289 102 0.029
immune system disease DOID:2914 155 0.025
acquired metabolic disease DOID:0060158 58 0.023
retinal degeneration DOID:8466 89 0.018
leukodystrophy DOID:10579 8 0.013
degeneration of macula and posterior pole DOID:2007 17 0.011
macular degeneration DOID:4448 20 0.011
age related macular degeneration DOID:10871 17 0.011