Homo sapiens

57 known processes

CUL4B

cullin 4B

(Aliases: SFM2,MRXHF2,DKFZp686F1470,MRXSC,KIAA0695,MRXS15)

CUL4B biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
post embryonic development GO:0009791 2 0.969
cellular macromolecule catabolic process GO:0044265 380 0.464
nucleoside catabolic process GO:0009164 408 0.381
purine ribonucleotide catabolic process GO:0009154 404 0.374
cellular response to dna damage stimulus GO:0006974 379 0.369
posttranscriptional regulation of gene expression GO:0010608 213 0.352
covalent chromatin modification GO:0016569 254 0.336
ribonucleoside catabolic process GO:0042454 406 0.335
purine ribonucleoside catabolic process GO:0046130 398 0.268
regulation of mitotic cell cycle GO:0007346 189 0.246
Mouse Fly
negative regulation of protein metabolic process GO:0051248 391 0.244
regulation of cell cycle GO:0051726 393 0.242
Mouse Fly
purine nucleoside triphosphate catabolic process GO:0009146 392 0.237
negative regulation of cellular protein metabolic process GO:0032269 353 0.236
purine nucleoside triphosphate metabolic process GO:0009144 412 0.235
histone h2a ubiquitination GO:0033522 17 0.231
nucleoside triphosphate catabolic process GO:0009143 394 0.229
proteasomal protein catabolic process GO:0010498 176 0.223
modification dependent macromolecule catabolic process GO:0043632 212 0.221
regulation of purine nucleotide metabolic process GO:1900542 264 0.206
cell development GO:0048468 328 0.194
Rat Fly
glycosyl compound catabolic process GO:1901658 413 0.193
purine nucleotide catabolic process GO:0006195 405 0.184
cellular component morphogenesis GO:0032989 314 0.175
Fly
histone modification GO:0016570 251 0.166
ribonucleoside triphosphate catabolic process GO:0009203 391 0.164
protein modification by small protein removal GO:0070646 92 0.163
neuromuscular junction development GO:0007528 3 0.163
ribonucleotide catabolic process GO:0009261 405 0.162
chromatin modification GO:0016568 298 0.154
purine ribonucleoside metabolic process GO:0046128 437 0.152
protein monoubiquitination GO:0006513 39 0.150
growth GO:0040007 202 0.150
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.148
ribonucleoside triphosphate metabolic process GO:0009199 412 0.147
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.141
nucleoside triphosphate metabolic process GO:0009141 422 0.132
positive regulation of nucleoside metabolic process GO:0045979 186 0.132
positive regulation of nucleotide catabolic process GO:0030813 185 0.131
regulation of nucleotide metabolic process GO:0006140 269 0.131
organophosphate catabolic process GO:0046434 430 0.127
embryo development GO:0009790 123 0.122
ubiquitin dependent protein catabolic process GO:0006511 206 0.120
nucleotide catabolic process GO:0009166 408 0.116
nucleoside phosphate catabolic process GO:1901292 412 0.116
regulation of cell differentiation GO:0045595 393 0.114
rna processing GO:0006396 255 0.110
rho protein signal transduction GO:0007266 26 0.108
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.107
nucleus localization GO:0051647 1 0.106
nervous system development GO:0007399 293 0.105
Rat
reproductive process GO:0022414 106 0.104
Fly
histone monoubiquitination GO:0010390 20 0.101
mitotic cell cycle process GO:1903047 286 0.097
Mouse Fly
cellular macromolecular complex assembly GO:0034622 324 0.097
cell cell signaling GO:0007267 155 0.094
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.090
purine nucleoside catabolic process GO:0006152 398 0.089
cellular protein catabolic process GO:0044257 261 0.088
multicellular organismal aging GO:0010259 3 0.088
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.086
histone ubiquitination GO:0016574 31 0.086
small gtpase mediated signal transduction GO:0007264 78 0.085
positive regulation of protein phosphorylation GO:0001934 313 0.084
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.078
spermatid development GO:0007286 4 0.076
organelle localization GO:0051640 84 0.073
positive regulation of cell proliferation GO:0008284 301 0.073
behavior GO:0007610 112 0.072
positive regulation of meiotic cell cycle GO:0051446 2 0.070
positive regulation of phosphorylation GO:0042327 394 0.070
regulation of nucleoside metabolic process GO:0009118 209 0.069
single organism reproductive process GO:0044702 98 0.068
Fly
mitotic cell cycle GO:0000278 326 0.066
Mouse Fly
response to uv GO:0009411 73 0.065
positive regulation of nucleotide metabolic process GO:0045981 230 0.065
regulation of transferase activity GO:0051338 355 0.064
positive regulation of cell cycle GO:0045787 140 0.064
Mouse
guanosine containing compound metabolic process GO:1901068 244 0.064
nucleoside monophosphate catabolic process GO:0009125 159 0.063
regulation of cellular response to stress GO:0080135 244 0.063
regulation of growth GO:0040008 165 0.063
protein modification by small protein conjugation GO:0032446 342 0.062
reproductive structure development GO:0048608 55 0.060
cellular homeostasis GO:0019725 196 0.059
cellular amino acid metabolic process GO:0006520 116 0.057
regulation of cell cycle process GO:0010564 266 0.057
Mouse Fly
positive regulation of chromosome organization GO:2001252 41 0.056
positive regulation of immune system process GO:0002684 283 0.056
reproductive system development GO:0061458 56 0.055
dna repair GO:0006281 198 0.054
reproduction GO:0000003 63 0.054
Fly
regulation of cell cycle phase transition GO:1901987 126 0.054
Mouse Fly
response to virus GO:0009615 126 0.054
mitotic dna damage checkpoint GO:0044773 28 0.054
Fly
positive regulation of organelle organization GO:0010638 195 0.053
regulation of locomotion GO:0040012 329 0.052
positive regulation of transferase activity GO:0051347 227 0.052
rhythmic behavior GO:0007622 2 0.051
spermatid differentiation GO:0048515 4 0.051
regulation of meiotic cell cycle GO:0051445 4 0.050
chromatin organization GO:0006325 351 0.050
embryonic epithelial tube formation GO:0001838 4 0.050
cell cycle checkpoint GO:0000075 117 0.050
Fly
determination of adult lifespan GO:0008340 2 0.049
tripartite regional subdivision GO:0007351 2 0.049
positive regulation of hydrolase activity GO:0051345 331 0.048
immune system development GO:0002520 195 0.047
regulation of response to dna damage stimulus GO:2001020 94 0.046
oogenesis GO:0048477 2 0.045
Fly
double strand break repair GO:0006302 101 0.045
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.045
multicellular organismal reproductive process GO:0048609 40 0.045
Fly
multicellular organism reproduction GO:0032504 42 0.045
Fly
establishment of organelle localization GO:0051656 59 0.045
sex differentiation GO:0007548 45 0.044
regulation of cellular amino acid metabolic process GO:0006521 6 0.044
ras protein signal transduction GO:0007265 73 0.043
modification dependent protein catabolic process GO:0019941 209 0.043
regulation of gtpase activity GO:0043087 180 0.043
regulation of protein complex assembly GO:0043254 147 0.042
female gamete generation GO:0007292 2 0.042
Fly
hematopoietic or lymphoid organ development GO:0048534 186 0.042
fertilization GO:0009566 12 0.042
regulation of cellular amine metabolic process GO:0033238 11 0.041
purine nucleoside monophosphate catabolic process GO:0009128 158 0.041
multi organism reproductive process GO:0044703 54 0.041
Fly
regulation of cell motility GO:2000145 299 0.041
regulation of protein processing GO:0070613 150 0.040
regulation of cellular component movement GO:0051270 334 0.040
actin filament organization GO:0007015 128 0.039
negative regulation of catalytic activity GO:0043086 335 0.038
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.038
positive regulation of catabolic process GO:0009896 310 0.038
Mouse Fly
ribonucleoside monophosphate metabolic process GO:0009161 187 0.037
pattern specification process GO:0007389 43 0.036
endocytosis GO:0006897 159 0.036
blastoderm segmentation GO:0007350 2 0.036
chordate embryonic development GO:0043009 34 0.036
membrane organization GO:0061024 292 0.035
cell projection organization GO:0030030 252 0.035
Rat
generation of neurons GO:0048699 152 0.035
Rat
regulation of nucleotide catabolic process GO:0030811 205 0.035
cellular response to endogenous stimulus GO:0071495 336 0.035
regulation of protein kinase activity GO:0045859 289 0.034
histone h2a monoubiquitination GO:0035518 11 0.034
negative regulation of cell cycle GO:0045786 193 0.034
Fly
protein maturation GO:0051604 233 0.034
gtp metabolic process GO:0046039 239 0.034
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.034
positive regulation of cellular component organization GO:0051130 376 0.034
anterior posterior axis specification GO:0009948 2 0.033
morphogenesis of embryonic epithelium GO:0016331 4 0.033
locomotory behavior GO:0007626 1 0.033
dna damage checkpoint GO:0000077 68 0.033
Fly
mrna metabolic process GO:0016071 175 0.033
purine containing compound catabolic process GO:0072523 411 0.033
negative regulation of protein modification process GO:0031400 200 0.032
negative regulation of multicellular organismal process GO:0051241 317 0.032
actin filament based process GO:0030029 224 0.031
stem cell development GO:0048864 69 0.031
regulation of mitotic cell cycle phase transition GO:1901990 118 0.031
Mouse Fly
regulation of atp catabolic process GO:1903289 25 0.031
oocyte differentiation GO:0009994 2 0.031
cell cycle phase transition GO:0044770 173 0.031
Mouse Fly
positive regulation of cytokine production GO:0001819 167 0.030
negative regulation of phosphorus metabolic process GO:0010563 267 0.030
organ morphogenesis GO:0009887 147 0.030
response to abiotic stimulus GO:0009628 336 0.029
regulation of gtp catabolic process GO:0033124 180 0.029
segmentation GO:0035282 4 0.029
regulation of immune response GO:0050776 201 0.029
microtubule based process GO:0007017 210 0.029
regulation of rho protein signal transduction GO:0035023 79 0.029
negative regulation of cell differentiation GO:0045596 171 0.029
atp catabolic process GO:0006200 157 0.029
rna splicing GO:0008380 131 0.028
circulatory system development GO:0072359 262 0.028
chemotaxis GO:0006935 157 0.028
cell morphogenesis involved in differentiation GO:0000904 144 0.028
blastocyst development GO:0001824 3 0.028
peptidyl serine modification GO:0018209 106 0.028
mitotic cell cycle phase transition GO:0044772 162 0.028
Mouse Fly
skeletal system development GO:0001501 79 0.028
g1 s transition of mitotic cell cycle GO:0000082 78 0.028
Mouse
regulation of canonical wnt signaling pathway GO:0060828 88 0.027
actin cytoskeleton organization GO:0030036 207 0.027
lipid localization GO:0010876 106 0.027
mapk cascade GO:0000165 288 0.027
amine metabolic process GO:0009308 44 0.027
protein ubiquitination GO:0016567 314 0.027
carbohydrate derivative biosynthetic process GO:1901137 207 0.027
cell morphogenesis GO:0000902 296 0.027
oocyte development GO:0048599 1 0.027
response to wounding GO:0009611 168 0.027
atp metabolic process GO:0046034 176 0.027
circadian sleep wake cycle sleep GO:0050802 2 0.026
stem cell maintenance GO:0019827 19 0.025
organelle fission GO:0048285 149 0.025
glycoprotein biosynthetic process GO:0009101 91 0.025
response to other organism GO:0051707 261 0.025
development of primary sexual characteristics GO:0045137 35 0.025
negative regulation of phosphate metabolic process GO:0045936 267 0.025
vesicle mediated transport GO:0016192 371 0.025
regulation of dna metabolic process GO:0051052 153 0.025
neuron differentiation GO:0030182 138 0.024
Rat
long term memory GO:0007616 2 0.024
ribonucleoside monophosphate catabolic process GO:0009158 158 0.024
developmental process involved in reproduction GO:0003006 66 0.024
Fly
memory GO:0007613 3 0.024
regulation of ras protein signal transduction GO:0046578 155 0.023
negative regulation of mitotic cell cycle GO:0045930 102 0.023
Fly
regulation of cell activation GO:0050865 125 0.023
male gamete generation GO:0048232 22 0.023
myeloid cell differentiation GO:0030099 117 0.023
signal transduction by phosphorylation GO:0023014 297 0.023
cell fate commitment involved in pattern specification GO:0060581 1 0.022
cell activation GO:0001775 213 0.022
cardiovascular system development GO:0072358 262 0.022
regulation of protein ubiquitination GO:0031396 95 0.022
canonical wnt signaling pathway GO:0060070 116 0.022
mrna processing GO:0006397 133 0.022
regulation of cytoplasmic transport GO:1903649 149 0.021
Fly
negative regulation of cell proliferation GO:0008285 228 0.021
golgi vesicle transport GO:0048193 80 0.021
negative regulation of immune system process GO:0002683 136 0.021
cyclin catabolic process GO:0008054 6 0.021
system process GO:0003008 349 0.020
negative regulation of apoptotic process GO:0043066 316 0.020
central nervous system development GO:0007417 123 0.020
positive regulation of developmental process GO:0051094 314 0.020
regulation of cellular component biogenesis GO:0044087 281 0.020
regulation of ras gtpase activity GO:0032318 128 0.020
gtp catabolic process GO:0006184 237 0.020
gonad development GO:0008406 34 0.020
regulation of g1 s transition of mitotic cell cycle GO:2000045 40 0.020
Mouse
posttranscriptional gene silencing GO:0016441 25 0.020
cellular amine metabolic process GO:0044106 41 0.019
positive regulation of transport GO:0051050 336 0.019
Fly
positive regulation of cellular catabolic process GO:0031331 284 0.019
tube development GO:0035295 125 0.019
mitotic nuclear division GO:0007067 119 0.019
anatomical structure formation involved in morphogenesis GO:0048646 284 0.019
Fly
regulation of response to wounding GO:1903034 101 0.019
regulation of chromosome organization GO:0033044 103 0.019
single organism membrane organization GO:0044802 268 0.019
establishment of nucleus localization GO:0040023 1 0.019
head development GO:0060322 108 0.018
regulation of epithelial cell proliferation GO:0050678 113 0.018
cell cycle g1 s phase transition GO:0044843 80 0.018
Mouse
positive regulation of cellular amine metabolic process GO:0033240 7 0.018
regulation of cytokine production GO:0001817 232 0.018
wnt signaling pathway GO:0016055 156 0.017
positive regulation of apoptotic process GO:0043065 246 0.017
regulation of myeloid cell differentiation GO:0045637 81 0.017
response to nitrogen compound GO:1901698 184 0.017
regulation of actin filament based process GO:0032970 141 0.017
protein catabolic process GO:0030163 325 0.017
Mouse Fly
regulation of rna splicing GO:0043484 62 0.017
regulation of stress activated mapk cascade GO:0032872 84 0.016
cell part morphogenesis GO:0032990 137 0.016
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.016
protein stabilization GO:0050821 64 0.016
regulation of small gtpase mediated signal transduction GO:0051056 156 0.016
positive regulation of immune response GO:0050778 159 0.016
leukocyte differentiation GO:0002521 98 0.016
positive regulation of proteolysis GO:0045862 142 0.016
myeloid leukocyte differentiation GO:0002573 60 0.016
cytokine production GO:0001816 247 0.016
regulation of peptidyl serine phosphorylation GO:0033135 50 0.016
skeletal system morphogenesis GO:0048705 24 0.016
biological adhesion GO:0022610 331 0.016
regulation of intracellular protein transport GO:0033157 123 0.016
Fly
multicellular organismal metabolic process GO:0044236 34 0.016
cellular cation homeostasis GO:0030003 163 0.016
mitotic cell cycle checkpoint GO:0007093 68 0.015
Fly
regulation of cell migration GO:0030334 289 0.015
regulation of response to external stimulus GO:0032101 222 0.015
vasculature development GO:0001944 181 0.015
cell division GO:0051301 168 0.015
positive regulation of programmed cell death GO:0043068 249 0.015
leukocyte activation GO:0045321 164 0.015
stem cell division GO:0017145 2 0.015
nuclear division GO:0000280 128 0.015
taxis GO:0042330 157 0.015
regulation of protein polymerization GO:0032271 63 0.015
chemical homeostasis GO:0048878 306 0.015
epithelial cell migration GO:0010631 119 0.015
regulation of protein stability GO:0031647 87 0.015
neuron development GO:0048666 113 0.015
Rat
regulation of leukocyte migration GO:0002685 63 0.015
positive regulation of cell differentiation GO:0045597 211 0.015
defense response GO:0006952 315 0.015
regulation of purine nucleotide catabolic process GO:0033121 205 0.015
negative regulation of protein maturation GO:1903318 142 0.015
developmental growth GO:0048589 48 0.015
cell adhesion GO:0007155 325 0.014
anterior posterior axis specification embryo GO:0008595 2 0.014
negative regulation of protein processing GO:0010955 142 0.014
axis elongation GO:0003401 4 0.014
cellular protein complex assembly GO:0043623 188 0.014
cytosolic calcium ion homeostasis GO:0051480 89 0.014
regulation of mitosis GO:0007088 63 0.014
dna conformation change GO:0071103 113 0.014
regulation of protein catabolic process GO:0042176 155 0.014
Mouse Fly
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.014
positive regulation of ras gtpase activity GO:0032320 117 0.014
nucleoside monophosphate metabolic process GO:0009123 191 0.014
muscle structure development GO:0061061 98 0.014
intrinsic apoptotic signaling pathway GO:0097193 127 0.014
leukocyte proliferation GO:0070661 74 0.014
regulation of actin filament polymerization GO:0030833 50 0.014
regulation of kinase activity GO:0043549 314 0.014
glial cell migration GO:0008347 4 0.014
cell growth GO:0016049 160 0.014
positive regulation of histone modification GO:0031058 29 0.013
cell fate determination GO:0001709 3 0.013
regulation of proteolysis GO:0030162 293 0.013
cellular response to abiotic stimulus GO:0071214 117 0.013
negative regulation of developmental process GO:0051093 247 0.013
positive regulation of atpase activity GO:0032781 19 0.013
negative regulation of protein phosphorylation GO:0001933 140 0.013
regulation of anatomical structure size GO:0090066 101 0.013
negative regulation of catabolic process GO:0009895 104 0.013
calcium ion homeostasis GO:0055074 122 0.013
negative regulation of cell death GO:0060548 345 0.013
receptor mediated endocytosis GO:0006898 84 0.013
response to light stimulus GO:0009416 87 0.013
hemopoiesis GO:0030097 180 0.013
regulation of protein maturation GO:1903317 150 0.013
neuroblast proliferation GO:0007405 4 0.013
purine nucleoside monophosphate metabolic process GO:0009126 186 0.013
organophosphate biosynthetic process GO:0090407 163 0.013
positive regulation of intracellular transport GO:0032388 104 0.013
Fly
positive regulation of protein kinase activity GO:0045860 190 0.012
guanosine containing compound catabolic process GO:1901069 239 0.012
maintenance of location GO:0051235 112 0.012
regulation of vesicle mediated transport GO:0060627 130 0.012
blood vessel development GO:0001568 172 0.012
cellular divalent inorganic cation homeostasis GO:0072503 128 0.012
neurogenesis GO:0022008 169 0.012
Rat
mitotic sister chromatid separation GO:0051306 18 0.012
neural nucleus development GO:0048857 47 0.012
regulation of granulocyte differentiation GO:0030852 11 0.012
gamete generation GO:0007276 25 0.012
Fly
regulation of intracellular transport GO:0032386 195 0.012
Fly
negative regulation of growth GO:0045926 97 0.012
nuclear migration GO:0007097 1 0.012
organelle fusion GO:0048284 36 0.012
cullin deneddylation GO:0010388 9 0.012
positive regulation of cell death GO:0010942 263 0.012
rna interference GO:0016246 4 0.012
negative regulation of myeloid cell differentiation GO:0045638 42 0.011
regulation of wnt signaling pathway GO:0030111 123 0.011
negative regulation of cellular component organization GO:0051129 235 0.011
peptidyl serine phosphorylation GO:0018105 101 0.011
somatic stem cell maintenance GO:0035019 4 0.011
regulation of translation GO:0006417 89 0.011
sexual reproduction GO:0019953 37 0.011
Fly
epithelial cell proliferation GO:0050673 128 0.011
development of primary male sexual characteristics GO:0046546 23 0.011
protein deneddylation GO:0000338 10 0.011
nuclear transcribed mrna catabolic process GO:0000956 48 0.011
response to external biotic stimulus GO:0043207 261 0.011
negative regulation of phosphorylation GO:0042326 174 0.011
positive regulation of leukocyte activation GO:0002696 80 0.011
regulation of atpase activity GO:0043462 25 0.011
regulation of cell growth GO:0001558 135 0.011
regulation of dephosphorylation GO:0035303 96 0.011
regulation of cellular ketone metabolic process GO:0010565 50 0.011
embryo development ending in birth or egg hatching GO:0009792 34 0.011
circadian behavior GO:0048512 2 0.011
axon development GO:0061564 34 0.011
regulation of nervous system development GO:0051960 88 0.011
positive regulation of cell cycle phase transition GO:1901989 22 0.011
Mouse
negative regulation of hydrolase activity GO:0051346 182 0.011
posttranscriptional gene silencing by rna GO:0035194 25 0.011
mitotic g2 m transition checkpoint GO:0044818 9 0.011
Fly
regulation of anatomical structure morphogenesis GO:0022603 286 0.011
cellular chemical homeostasis GO:0055082 180 0.011
response to growth factor GO:0070848 205 0.010
uv damage excision repair GO:0070914 7 0.010
positive regulation of gtpase activity GO:0043547 166 0.010
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.010
ncrna catabolic process GO:0034661 14 0.010
cellular response to oxygen containing compound GO:1901701 276 0.010
primary neural tube formation GO:0014020 3 0.010
positive regulation of mononuclear cell proliferation GO:0032946 47 0.010
regulation of cytoskeleton organization GO:0051493 177 0.010

CUL4B disease predictions

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 186 0.018
neurodegenerative disease DOID:1289 102 0.018
nervous system disease DOID:863 431 0.018
sensory system disease DOID:0050155 203 0.013
immune system disease DOID:2914 155 0.012
anemia DOID:2355 55 0.012
hematopoietic system disease DOID:74 100 0.012