Homo sapiens

86 known processes

DDB1

damage-specific DNA binding protein 1, 127kDa

(Aliases: XPCE,DDBA,XPE,XPE-BF,UV-DDB1,XAP1)

DDB1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
chromatin modification GO:0016568 298 0.986
cellular response to dna damage stimulus GO:0006974 379 0.982
covalent chromatin modification GO:0016569 254 0.967
dna repair GO:0006281 198 0.952
protein ubiquitination GO:0016567 314 0.947
cell competition in a multicellular organism GO:0035212 1 0.928
protein modification by small protein conjugation GO:0032446 342 0.925
chromatin organization GO:0006325 351 0.913
peptidyl threonine phosphorylation GO:0018107 41 0.891
cellular response to abiotic stimulus GO:0071214 117 0.882
regulation of cell cycle GO:0051726 393 0.851
cellular response to uv GO:0034644 32 0.844
uv damage excision repair GO:0070914 7 0.832
regulation of mitotic cell cycle phase transition GO:1901990 118 0.785
regulation of cell cycle process GO:0010564 266 0.773
dna damage checkpoint GO:0000077 68 0.701
growth GO:0040007 202 0.695
response to uv GO:0009411 73 0.603
somatic stem cell maintenance GO:0035019 4 0.598
protein catabolic process GO:0030163 325 0.598
regulation of growth GO:0040008 165 0.585
histone h2a ubiquitination GO:0033522 17 0.584
response to light stimulus GO:0009416 87 0.575
protein monoubiquitination GO:0006513 39 0.569
response to radiation GO:0009314 151 0.558
cellular response to light stimulus GO:0071482 34 0.533
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.493
mitotic dna damage checkpoint GO:0044773 28 0.481
mitotic cell cycle process GO:1903047 286 0.461
regulation of mitotic cell cycle GO:0007346 189 0.436
regulation of dna metabolic process GO:0051052 153 0.435
response to abiotic stimulus GO:0009628 336 0.410
histone phosphorylation GO:0016572 16 0.404
mitotic cell cycle checkpoint GO:0007093 68 0.368
cell cycle phase transition GO:0044770 173 0.350
cellular response to radiation GO:0071478 65 0.338
cellular macromolecule catabolic process GO:0044265 380 0.333
cell cycle checkpoint GO:0000075 117 0.328
peptidyl threonine modification GO:0018210 45 0.309
cellular protein catabolic process GO:0044257 261 0.300
regulation of response to dna damage stimulus GO:2001020 94 0.293
protein modification by small protein removal GO:0070646 92 0.289
modification dependent protein catabolic process GO:0019941 209 0.281
double strand break repair GO:0006302 101 0.274
histone h2a monoubiquitination GO:0035518 11 0.237
g1 s transition of mitotic cell cycle GO:0000082 78 0.234
dna integrity checkpoint GO:0031570 71 0.227
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.226
regulation of g1 s transition of mitotic cell cycle GO:2000045 40 0.225
single organism cellular localization GO:1902580 332 0.220
single organism carbohydrate metabolic process GO:0044723 193 0.217
atp catabolic process GO:0006200 157 0.199
mitotic sister chromatid segregation GO:0000070 53 0.192
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.190
nucleoside monophosphate catabolic process GO:0009125 159 0.183
mitotic cell cycle phase transition GO:0044772 162 0.174
regulation of cell cycle g1 s phase transition GO:1902806 42 0.170
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.166
ribonucleoside monophosphate catabolic process GO:0009158 158 0.161
purine nucleotide catabolic process GO:0006195 405 0.161
mitotic cell cycle GO:0000278 326 0.158
modification dependent macromolecule catabolic process GO:0043632 212 0.152
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.141
negative regulation of cell differentiation GO:0045596 171 0.130
proteasomal protein catabolic process GO:0010498 176 0.127
purine ribonucleotide catabolic process GO:0009154 404 0.125
nuclear division GO:0000280 128 0.122
negative regulation of multicellular organismal process GO:0051241 317 0.118
negative regulation of cell cycle GO:0045786 193 0.118
ribonucleoside triphosphate catabolic process GO:0009203 391 0.110
nucleoside triphosphate catabolic process GO:0009143 394 0.110
nucleosome positioning GO:0016584 3 0.109
histone modification GO:0016570 251 0.104
regulation of cell cycle phase transition GO:1901987 126 0.103
positive regulation of cell cycle process GO:0090068 106 0.103
purine ribonucleoside metabolic process GO:0046128 437 0.100
histone h2a phosphorylation GO:1990164 3 0.100
regulation of protein catabolic process GO:0042176 155 0.097
cell development GO:0048468 328 0.094
atp metabolic process GO:0046034 176 0.091
positive regulation of mitotic cell cycle GO:0045931 60 0.089
cellular carbohydrate metabolic process GO:0044262 84 0.087
positive regulation of cell cycle GO:0045787 140 0.083
regulation of cellular response to stress GO:0080135 244 0.082
positive regulation of proteasomal protein catabolic process GO:1901800 35 0.081
posttranscriptional regulation of gene expression GO:0010608 213 0.078
protein autoubiquitination GO:0051865 37 0.077
myeloid cell differentiation GO:0030099 117 0.076
regulation of cellular protein catabolic process GO:1903362 96 0.076
negative regulation of cell cycle process GO:0010948 121 0.075
cell cycle g1 s phase transition GO:0044843 80 0.074
protein localization to nucleus GO:0034504 136 0.073
determination of adult lifespan GO:0008340 2 0.072
carbohydrate metabolic process GO:0005975 207 0.070
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.069
multicellular organismal aging GO:0010259 3 0.068
regulation of proteasomal protein catabolic process GO:0061136 87 0.066
nucleoside monophosphate metabolic process GO:0009123 191 0.065
hemopoiesis GO:0030097 180 0.064
mitotic dna integrity checkpoint GO:0044774 30 0.064
stem cell differentiation GO:0048863 93 0.063
negative regulation of mitotic cell cycle GO:0045930 102 0.063
protein deneddylation GO:0000338 10 0.061
ubiquitin dependent protein catabolic process GO:0006511 206 0.059
regulation of cell growth GO:0001558 135 0.058
purine containing compound catabolic process GO:0072523 411 0.058
negative regulation of leukocyte differentiation GO:1902106 24 0.057
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.057
stem cell development GO:0048864 69 0.057
regulation of tor signaling GO:0032006 30 0.057
positive regulation of cell proliferation GO:0008284 301 0.056
histone monoubiquitination GO:0010390 20 0.056
regulation of proteolysis GO:0030162 293 0.056
ribonucleoside monophosphate metabolic process GO:0009161 187 0.055
protein polyubiquitination GO:0000209 110 0.055
microtubule based process GO:0007017 210 0.054
immune system development GO:0002520 195 0.053
nucleoside phosphate catabolic process GO:1901292 412 0.051
regulation of myeloid cell differentiation GO:0045637 81 0.051
positive regulation of protein catabolic process GO:0045732 75 0.050
mapk cascade GO:0000165 288 0.050
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.049
nucleoside catabolic process GO:0009164 408 0.049
regulation of dna repair GO:0006282 47 0.049
leukocyte differentiation GO:0002521 98 0.048
carbohydrate catabolic process GO:0016052 36 0.047
positive regulation of proteolysis GO:0045862 142 0.047
regulation of leukocyte differentiation GO:1902105 61 0.047
embryo development GO:0009790 123 0.047
Worm
purine nucleoside triphosphate metabolic process GO:0009144 412 0.046
nucleotide catabolic process GO:0009166 408 0.046
g2 dna damage checkpoint GO:0031572 26 0.045
purine nucleoside monophosphate metabolic process GO:0009126 186 0.045
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.045
cellular macromolecular complex assembly GO:0034622 324 0.043
positive regulation of protein transport GO:0051222 135 0.043
purine nucleoside monophosphate catabolic process GO:0009128 158 0.042
cullin deneddylation GO:0010388 9 0.041
cellular amino acid metabolic process GO:0006520 116 0.040
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.040
double strand break repair via homologous recombination GO:0000724 50 0.039
protein deubiquitination GO:0016579 79 0.039
oocyte differentiation GO:0009994 2 0.038
purine ribonucleoside catabolic process GO:0046130 398 0.038
glycosyl compound catabolic process GO:1901658 413 0.038
regulation of locomotion GO:0040012 329 0.037
mitotic g2 dna damage checkpoint GO:0007095 7 0.037
monocarboxylic acid metabolic process GO:0032787 185 0.037
cellular component disassembly GO:0022411 92 0.035
post embryonic development GO:0009791 2 0.035
Worm
intracellular protein transport GO:0006886 270 0.035
negative regulation of cell proliferation GO:0008285 228 0.034
mitotic g2 m transition checkpoint GO:0044818 9 0.034
hematopoietic or lymphoid organ development GO:0048534 186 0.033
negative regulation of cell death GO:0060548 345 0.033
Mouse
regulation of cell differentiation GO:0045595 393 0.033
apoptotic signaling pathway GO:0097190 268 0.032
regulation of protein stability GO:0031647 87 0.032
female gamete generation GO:0007292 2 0.031
negative regulation of immune system process GO:0002683 136 0.031
organophosphate catabolic process GO:0046434 430 0.031
nervous system development GO:0007399 293 0.031
negative regulation of cell cycle phase transition GO:1901988 89 0.030
cellular response to endogenous stimulus GO:0071495 336 0.030
cell division GO:0051301 168 0.029
cellular protein complex assembly GO:0043623 188 0.029
purine nucleoside triphosphate catabolic process GO:0009146 392 0.029
positive regulation of growth GO:0045927 58 0.029
sister chromatid segregation GO:0000819 54 0.029
dna recombination GO:0006310 77 0.029
blastoderm segmentation GO:0007350 2 0.029
histone ubiquitination GO:0016574 31 0.028
negative regulation of proteolysis GO:0045861 132 0.028
negative regulation of protein metabolic process GO:0051248 391 0.028
negative regulation of granulocyte differentiation GO:0030853 5 0.028
protein targeting GO:0006605 187 0.027
regulation of cellular ketone metabolic process GO:0010565 50 0.027
regulation of cell motility GO:2000145 299 0.027
small molecule biosynthetic process GO:0044283 157 0.027
protein stabilization GO:0050821 64 0.027
regulation of transferase activity GO:0051338 355 0.027
nuclear transport GO:0051169 179 0.027
negative regulation of catalytic activity GO:0043086 335 0.027
reproduction GO:0000003 63 0.027
Worm
protein maturation GO:0051604 233 0.027
regulation of chromosome organization GO:0033044 103 0.027
reactive oxygen species metabolic process GO:0072593 75 0.027
cellular amine metabolic process GO:0044106 41 0.027
regulation of dna damage checkpoint GO:2000001 9 0.026
cytoplasmic transport GO:0016482 379 0.026
regulation of establishment of protein localization GO:0070201 242 0.026
neuron differentiation GO:0030182 138 0.026
positive regulation of catabolic process GO:0009896 310 0.026
purine nucleoside catabolic process GO:0006152 398 0.025
rna interference GO:0016246 4 0.025
regulation of myeloid leukocyte differentiation GO:0002761 39 0.025
cell activation GO:0001775 213 0.025
locomotory behavior GO:0007626 1 0.024
endocytosis GO:0006897 159 0.024
Worm
ribonucleotide catabolic process GO:0009261 405 0.024
segmentation GO:0035282 4 0.024
regulation of cytoplasmic transport GO:1903649 149 0.024
ribonucleoside catabolic process GO:0042454 406 0.024
macromolecular complex disassembly GO:0032984 60 0.024
vesicle mediated transport GO:0016192 371 0.024
Worm
regulation of protein maturation GO:1903317 150 0.023
negative regulation of apoptotic process GO:0043066 316 0.023
Mouse
positive regulation of mitotic cell cycle phase transition GO:1901992 19 0.023
negative regulation of proteasomal protein catabolic process GO:1901799 32 0.023
oogenesis GO:0048477 2 0.023
protein processing GO:0016485 226 0.023
mitotic nuclear division GO:0007067 119 0.022
lipid localization GO:0010876 106 0.022
positive regulation of developmental process GO:0051094 314 0.022
signal transduction by phosphorylation GO:0023014 297 0.021
cell cycle arrest GO:0007050 71 0.021
regulation of protein processing GO:0070613 150 0.021
methylation GO:0032259 106 0.021
positive regulation of nucleocytoplasmic transport GO:0046824 54 0.021
nucleoside triphosphate metabolic process GO:0009141 422 0.021
regeneration GO:0031099 4 0.021
regulation of carbohydrate metabolic process GO:0006109 54 0.021
lipid biosynthetic process GO:0008610 177 0.021
cell projection organization GO:0030030 252 0.021
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.021
regulation of intracellular protein transport GO:0033157 123 0.021
negative regulation of catabolic process GO:0009895 104 0.020
glial cell migration GO:0008347 4 0.020
cytokinesis GO:0000910 96 0.020
myeloid leukocyte differentiation GO:0002573 60 0.020
developmental process involved in reproduction GO:0003006 66 0.020
Worm
macromolecule methylation GO:0043414 97 0.020
single organism nuclear import GO:1902593 104 0.019
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.019
regulation of intracellular transport GO:0032386 195 0.019
dna geometric change GO:0032392 32 0.019
negative regulation of cellular protein catabolic process GO:1903363 38 0.019
negative regulation of myeloid leukocyte differentiation GO:0002762 16 0.018
anatomical structure homeostasis GO:0060249 100 0.018
positive regulation of phosphorylation GO:0042327 394 0.018
microtubule cytoskeleton organization GO:0000226 176 0.018
negative regulation of intracellular signal transduction GO:1902532 183 0.018
cellular component morphogenesis GO:0032989 314 0.018
positive regulation of protein import into nucleus GO:0042307 46 0.018
cell cell signaling GO:0007267 155 0.018
development of primary sexual characteristics GO:0045137 35 0.018
Worm
nucleotide excision repair GO:0006289 31 0.018
nucleosome organization GO:0034728 66 0.018
response to ionizing radiation GO:0010212 65 0.018
cell growth GO:0016049 160 0.018
regulation of nucleocytoplasmic transport GO:0046822 98 0.018
generation of neurons GO:0048699 152 0.018
neuron development GO:0048666 113 0.018
negative regulation of phosphorus metabolic process GO:0010563 267 0.018
negative regulation of protein maturation GO:1903318 142 0.018
neurogenesis GO:0022008 169 0.018
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 35 0.017
regulation of cellular component movement GO:0051270 334 0.017
gonad development GO:0008406 34 0.017
Worm
regulation of dna replication GO:0006275 68 0.017
organelle fission GO:0048285 149 0.017
oocyte development GO:0048599 1 0.017
nuclear import GO:0051170 106 0.017
organic acid biosynthetic process GO:0016053 97 0.017
signal transduction by p53 class mediator GO:0072331 72 0.017
regulation of cellular amino acid metabolic process GO:0006521 6 0.017
protein import into nucleus GO:0006606 104 0.017
histone exchange GO:0043486 3 0.016
sex differentiation GO:0007548 45 0.016
Worm
oxidation reduction process GO:0055114 396 0.016
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.016
positive regulation of intracellular transport GO:0032388 104 0.016
generation of precursor metabolites and energy GO:0006091 68 0.016
lipid metabolic process GO:0006629 381 0.016
circulatory system development GO:0072359 262 0.016
positive regulation of apoptotic process GO:0043065 246 0.015
establishment of protein localization to organelle GO:0072594 172 0.015
cell morphogenesis GO:0000902 296 0.015
single organism carbohydrate catabolic process GO:0044724 33 0.015
response to wounding GO:0009611 168 0.015
immune response GO:0006955 307 0.015
multicellular organism reproduction GO:0032504 42 0.015
Worm
regulation of granulocyte differentiation GO:0030852 11 0.015
regulation of peptidase activity GO:0052547 180 0.015
molting cycle GO:0042303 28 0.015
negative regulation of phosphorylation GO:0042326 174 0.015
biological adhesion GO:0022610 331 0.015
regulation of cytokine production GO:0001817 232 0.014
positive regulation of dna metabolic process GO:0051054 73 0.014
regulation of cellular amine metabolic process GO:0033238 11 0.014
positive regulation of intracellular protein transport GO:0090316 76 0.014
negative regulation of protein processing GO:0010955 142 0.014
citrate metabolic process GO:0006101 2 0.014
negative regulation of protein catabolic process GO:0042177 59 0.014
neuron projection development GO:0031175 106 0.014
positive regulation of cytoplasmic transport GO:1903651 82 0.014
reproductive system development GO:0061458 56 0.014
Worm
positive regulation of cell death GO:0010942 263 0.014
positive regulation of programmed cell death GO:0043068 249 0.014
positive regulation of hydrolase activity GO:0051345 331 0.013
tube development GO:0035295 125 0.013
single organism reproductive process GO:0044702 98 0.013
Worm
regulation of protein serine threonine kinase activity GO:0071900 179 0.013
histone methylation GO:0016571 60 0.013
metencephalon development GO:0022037 2 0.013
protein targeting to nucleus GO:0044744 104 0.013
positive regulation of cellular amine metabolic process GO:0033240 7 0.013
regulation of kinase activity GO:0043549 314 0.013
negative regulation of myeloid cell differentiation GO:0045638 42 0.013
protein acylation GO:0043543 138 0.013
protein dna complex subunit organization GO:0071824 80 0.013
response to hormone GO:0009725 175 0.013
regulation of gene expression epigenetic GO:0040029 73 0.013
protein methylation GO:0006479 74 0.013
telomere maintenance GO:0000723 32 0.013
regulation of mapk cascade GO:0043408 262 0.013
tissue regeneration GO:0042246 3 0.013
peripheral nervous system development GO:0007422 2 0.013
dephosphorylation GO:0016311 209 0.013
autophagy GO:0006914 88 0.013
peptidyl lysine modification GO:0018205 144 0.012
jnk cascade GO:0007254 80 0.012
negative regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032435 30 0.012
regulation of cellular carbohydrate metabolic process GO:0010675 47 0.012
chromatin remodeling GO:0006338 55 0.012
cell adhesion GO:0007155 325 0.012
eye photoreceptor cell differentiation GO:0001754 2 0.012
epithelium development GO:0060429 227 0.012
positive regulation of cellular protein catabolic process GO:1903364 37 0.012
response to decreased oxygen levels GO:0036293 96 0.012
negative regulation of cellular component movement GO:0051271 106 0.012
photoreceptor cell differentiation GO:0046530 2 0.012
hematopoietic stem cell differentiation GO:0060218 4 0.012
positive regulation of nucleotide metabolic process GO:0045981 230 0.012
negative regulation of cellular catabolic process GO:0031330 83 0.012
reproductive structure development GO:0048608 55 0.012
Worm
secretion by cell GO:0032940 226 0.012
pyruvate metabolic process GO:0006090 26 0.012
negative regulation of growth GO:0045926 97 0.012
regulation of meiotic cell cycle GO:0051445 4 0.012
compound eye development GO:0048749 1 0.012
telomere maintenance via recombination GO:0000722 4 0.012
cellular response to organonitrogen compound GO:0071417 124 0.011
positive regulation of transcription factor import into nucleus GO:0042993 25 0.011
negative regulation of protein modification process GO:0031400 200 0.011
negative regulation of developmental process GO:0051093 247 0.011
regulation of lipid biosynthetic process GO:0046890 47 0.011
spermatid differentiation GO:0048515 4 0.011
glycolytic process GO:0006096 17 0.011
embryonic epithelial tube formation GO:0001838 4 0.011
cell projection morphogenesis GO:0048858 129 0.011
positive regulation of cellular catabolic process GO:0031331 284 0.011
positive regulation of transport GO:0051050 336 0.011
adult locomotory behavior GO:0008344 1 0.011
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 30 0.011
cellular ketone metabolic process GO:0042180 80 0.011
embryonic morphogenesis GO:0048598 85 0.011
negative regulation of transport GO:0051051 176 0.011
response to starvation GO:0042594 59 0.011
positive regulation of protein modification by small protein conjugation or removal GO:1903322 61 0.011
negative regulation of neuron death GO:1901215 32 0.011
intrinsic apoptotic signaling pathway GO:0097193 127 0.011
translation GO:0006412 132 0.010
extrinsic apoptotic signaling pathway GO:0097191 119 0.010
amine metabolic process GO:0009308 44 0.010
cardiac muscle cell contraction GO:0086003 4 0.010
positive regulation of protein phosphorylation GO:0001934 313 0.010
positive regulation of cytokine production GO:0001819 167 0.010
chromatin assembly GO:0031497 61 0.010
stress activated mapk cascade GO:0051403 93 0.010
gene silencing GO:0016458 49 0.010
neurological system process GO:0050877 163 0.010
visual behavior GO:0007632 2 0.010
reproductive process GO:0022414 106 0.010
Worm

DDB1 disease predictions

Disease DO term ID Size Probability Func Analog Org
xeroderma pigmentosum DOID:0050427 8 0.251
sensory system disease DOID:0050155 203 0.028
eye and adnexa disease DOID:1492 150 0.028
nervous system disease DOID:863 431 0.028
retinal disease DOID:5679 118 0.028
eye disease DOID:5614 149 0.028
central nervous system disease DOID:331 186 0.024
neurodegenerative disease DOID:1289 102 0.024
disease of metabolism DOID:0014667 295 0.012
muscular disease DOID:0080000 114 0.011
musculoskeletal system disease DOID:17 223 0.011
muscle tissue disease DOID:66 113 0.011