Homo sapiens

143 known processes

EIF2B3

eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa

(Aliases: EIF2Bgamma,EIF-2B)

EIF2B3 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
oligodendrocyte development GO:0014003 6 0.990
translation GO:0006412 132 0.321
positive regulation of nucleotide catabolic process GO:0030813 185 0.304
regulation of nucleotide catabolic process GO:0030811 205 0.303
posttranscriptional regulation of gene expression GO:0010608 213 0.301
Yeast Worm
positive regulation of nucleoside metabolic process GO:0045979 186 0.295
guanosine containing compound catabolic process GO:1901069 239 0.295
gtp catabolic process GO:0006184 237 0.274
regulation of gtp catabolic process GO:0033124 180 0.228
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.226
nucleoside triphosphate catabolic process GO:0009143 394 0.226
gtp metabolic process GO:0046039 239 0.211
positive regulation of nucleotide metabolic process GO:0045981 230 0.208
guanosine containing compound metabolic process GO:1901068 244 0.208
regulation of gtpase activity GO:0043087 180 0.196
positive regulation of gtpase activity GO:0043547 166 0.192
nucleoside catabolic process GO:0009164 408 0.176
positive regulation of gtp catabolic process GO:0033126 166 0.173
post embryonic development GO:0009791 2 0.168
Worm
positive regulation of cellular catabolic process GO:0031331 284 0.164
regulation of purine nucleotide metabolic process GO:1900542 264 0.164
nucleoside triphosphate metabolic process GO:0009141 422 0.159
mitochondrial respiratory chain complex i biogenesis GO:0097031 16 0.150
positive regulation of hydrolase activity GO:0051345 331 0.146
protein processing GO:0016485 226 0.138
system process GO:0003008 349 0.137
purine nucleoside triphosphate metabolic process GO:0009144 412 0.134
purine nucleotide catabolic process GO:0006195 405 0.125
vesicle mediated transport GO:0016192 371 0.116
Worm
nervous system development GO:0007399 293 0.114
ribonucleoside triphosphate catabolic process GO:0009203 391 0.109
protein maturation GO:0051604 233 0.095
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.095
translational initiation GO:0006413 48 0.092
response to hormone GO:0009725 175 0.089
nucleotide catabolic process GO:0009166 408 0.086
response to nitrogen compound GO:1901698 184 0.085
cellular amino acid metabolic process GO:0006520 116 0.083
purine nucleoside catabolic process GO:0006152 398 0.079
regulation of membrane potential GO:0042391 95 0.079
nadh dehydrogenase complex assembly GO:0010257 16 0.075
purine ribonucleoside metabolic process GO:0046128 437 0.075
regulation of purine nucleotide catabolic process GO:0033121 205 0.071
neurogenesis GO:0022008 169 0.071
purine ribonucleoside catabolic process GO:0046130 398 0.068
cellular amine metabolic process GO:0044106 41 0.064
response to peptide GO:1901652 65 0.064
trna metabolic process GO:0006399 35 0.061
regulation of translation GO:0006417 89 0.060
Yeast
carbohydrate derivative biosynthetic process GO:1901137 207 0.059
ribonucleotide biosynthetic process GO:0009260 81 0.059
ribonucleoside catabolic process GO:0042454 406 0.056
glial cell development GO:0021782 7 0.055
oligodendrocyte differentiation GO:0048709 7 0.055
regulation of nucleoside metabolic process GO:0009118 209 0.054
cell development GO:0048468 328 0.053
regulation of proteolysis GO:0030162 293 0.053
embryo development GO:0009790 123 0.052
Worm
oogenesis GO:0048477 2 0.050
organophosphate catabolic process GO:0046434 430 0.050
protein localization to organelle GO:0033365 280 0.049
ion homeostasis GO:0050801 230 0.048
single organism cellular localization GO:1902580 332 0.047
ribonucleotide catabolic process GO:0009261 405 0.044
trna aminoacylation for protein translation GO:0006418 8 0.044
receptor mediated endocytosis GO:0006898 84 0.044
Worm
cellular protein catabolic process GO:0044257 261 0.043
cell cell signaling GO:0007267 155 0.042
purine containing compound catabolic process GO:0072523 411 0.041
carbohydrate metabolic process GO:0005975 207 0.041
reproductive system development GO:0061458 56 0.041
positive regulation of transport GO:0051050 336 0.040
glycerol metabolic process GO:0006071 4 0.040
response to organonitrogen compound GO:0010243 156 0.038
negative regulation of protein metabolic process GO:0051248 391 0.038
cellular ketone metabolic process GO:0042180 80 0.037
action potential GO:0001508 34 0.037
gliogenesis GO:0042063 21 0.036
glycosyl compound catabolic process GO:1901658 413 0.035
cellular macromolecule catabolic process GO:0044265 380 0.035
growth GO:0040007 202 0.035
Worm
reproductive process GO:0022414 106 0.035
endocytosis GO:0006897 159 0.035
Worm
single organism membrane organization GO:0044802 268 0.034
nucleoside biosynthetic process GO:0009163 26 0.034
negative regulation of protein maturation GO:1903318 142 0.033
small molecule biosynthetic process GO:0044283 157 0.032
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.031
respiratory chain complex iv assembly GO:0008535 9 0.031
regulation of peptidase activity GO:0052547 180 0.029
neuronal action potential GO:0019228 9 0.029
positive regulation of catabolic process GO:0009896 310 0.028
transmembrane transport GO:0055085 399 0.028
establishment of protein localization to organelle GO:0072594 172 0.028
cellular chemical homeostasis GO:0055082 180 0.028
intracellular protein transport GO:0006886 270 0.028
transmission of nerve impulse GO:0019226 11 0.028
cytoplasmic transport GO:0016482 379 0.027
ribose phosphate biosynthetic process GO:0046390 82 0.027
rna processing GO:0006396 255 0.027
nucleoside phosphate catabolic process GO:1901292 412 0.026
negative regulation of protein processing GO:0010955 142 0.026
protein catabolic process GO:0030163 325 0.026
organonitrogen compound biosynthetic process GO:1901566 200 0.026
negative regulation of cellular protein metabolic process GO:0032269 353 0.026
protein acylation GO:0043543 138 0.026
ncrna metabolic process GO:0034660 108 0.025
response to oxygen containing compound GO:1901700 369 0.025
immune response GO:0006955 307 0.025
neurological system process GO:0050877 163 0.025
single organism carbohydrate metabolic process GO:0044723 193 0.025
defense response GO:0006952 315 0.025
membrane organization GO:0061024 292 0.025
monocarboxylic acid metabolic process GO:0032787 185 0.024
innate immune response GO:0045087 178 0.024
secretion GO:0046903 254 0.024
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.023
maintenance of location GO:0051235 112 0.023
embryo development ending in birth or egg hatching GO:0009792 34 0.023
Worm
trna aminoacylation GO:0043039 12 0.023
response to abiotic stimulus GO:0009628 336 0.023
cation homeostasis GO:0055080 189 0.023
cellular cation homeostasis GO:0030003 163 0.023
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.022
cellular carbohydrate metabolic process GO:0044262 84 0.022
regulation of cellular amino acid metabolic process GO:0006521 6 0.022
negative regulation of programmed cell death GO:0043069 321 0.022
mitochondrion organization GO:0007005 156 0.021
reproduction GO:0000003 63 0.021
Worm
regulation of immune response GO:0050776 201 0.021
response to other organism GO:0051707 261 0.021
response to peptide hormone GO:0043434 61 0.021
muscle system process GO:0003012 81 0.021
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.020
positive regulation of phosphorylation GO:0042327 394 0.020
positive regulation of apoptotic process GO:0043065 246 0.020
negative regulation of intracellular signal transduction GO:1902532 183 0.019
positive regulation of growth GO:0045927 58 0.019
Worm
multicellular organismal signaling GO:0035637 34 0.019
muscle contraction GO:0006936 73 0.019
positive regulation of cell death GO:0010942 263 0.019
anterior posterior axis specification GO:0009948 2 0.019
lipid metabolic process GO:0006629 381 0.019
trna splicing via endonucleolytic cleavage and ligation GO:0006388 7 0.019
regulation of protein stability GO:0031647 87 0.018
establishment of organelle localization GO:0051656 59 0.018
regulation of endopeptidase activity GO:0052548 170 0.018
reproductive structure development GO:0048608 55 0.018
carboxylic acid biosynthetic process GO:0046394 97 0.018
sex differentiation GO:0007548 45 0.018
actin filament based process GO:0030029 224 0.018
female gamete generation GO:0007292 2 0.017
amine metabolic process GO:0009308 44 0.017
positive regulation of programmed cell death GO:0043068 249 0.017
cellular ion homeostasis GO:0006873 168 0.017
negative regulation of apoptotic process GO:0043066 316 0.017
regulation of defense response GO:0031347 154 0.017
atp catabolic process GO:0006200 157 0.017
negative regulation of peptidase activity GO:0010466 91 0.017
response to biotic stimulus GO:0009607 276 0.017
adult locomotory behavior GO:0008344 1 0.017
regulation of protein maturation GO:1903317 150 0.017
cellular homeostasis GO:0019725 196 0.017
regulation of cysteine type endopeptidase activity GO:2000116 127 0.017
regulation of cellular amine metabolic process GO:0033238 11 0.016
chemical homeostasis GO:0048878 306 0.016
neuromuscular junction development GO:0007528 3 0.016
developmental process involved in reproduction GO:0003006 66 0.016
negative regulation of cell death GO:0060548 345 0.016
cellular protein complex assembly GO:0043623 188 0.016
trna aminoacylation for mitochondrial protein translation GO:0070127 3 0.016
regulation of protein processing GO:0070613 150 0.016
secretion by cell GO:0032940 226 0.015
cellular metal ion homeostasis GO:0006875 146 0.015
protein import GO:0017038 130 0.015
histone modification GO:0016570 251 0.015
negative regulation of phosphorylation GO:0042326 174 0.015
positive regulation of cellular amine metabolic process GO:0033240 7 0.015
cofactor biosynthetic process GO:0051188 31 0.015
cytokine production GO:0001816 247 0.015
single organism reproductive process GO:0044702 98 0.014
positive regulation of ion transport GO:0043270 87 0.014
protein targeting GO:0006605 187 0.014
cell projection organization GO:0030030 252 0.014
protein stabilization GO:0050821 64 0.014
quinone metabolic process GO:1901661 18 0.014
cellular lipid metabolic process GO:0044255 303 0.014
segmentation GO:0035282 4 0.013
apoptotic signaling pathway GO:0097190 268 0.013
cellular macromolecular complex assembly GO:0034622 324 0.013
regulation of protein kinase activity GO:0045859 289 0.013
locomotory behavior GO:0007626 1 0.013
negative regulation of proteolysis GO:0045861 132 0.013
regulation of kinase activity GO:0043549 314 0.013
positive regulation of developmental process GO:0051094 314 0.013
Worm
astrocyte differentiation GO:0048708 4 0.013
mitochondrial respiratory chain complex assembly GO:0033108 23 0.013
metal ion homeostasis GO:0055065 169 0.013
regulation of protein localization GO:0032880 296 0.013
ribonucleoside triphosphate metabolic process GO:0009199 412 0.013
protein acetylation GO:0006473 116 0.013
regulation of transmembrane transport GO:0034762 139 0.013
metal ion transport GO:0030001 272 0.013
protein localization to membrane GO:0072657 160 0.013
coenzyme biosynthetic process GO:0009108 24 0.013
regulation of cellular ketone metabolic process GO:0010565 50 0.013
regulation of protein transport GO:0051223 213 0.013
n terminal protein amino acid modification GO:0031365 13 0.012
positive regulation of peptidase activity GO:0010952 88 0.012
regeneration GO:0031099 4 0.012
regulation of nucleotide metabolic process GO:0006140 269 0.012
nuclear migration GO:0007097 1 0.012
response to virus GO:0009615 126 0.012
negative regulation of transferase activity GO:0051348 124 0.012
gonad development GO:0008406 34 0.012
cellular component morphogenesis GO:0032989 314 0.012
regulation of cytokine production GO:0001817 232 0.012
cellular response to oxygen containing compound GO:1901701 276 0.012
regulation of intracellular protein transport GO:0033157 123 0.012
regulation of transferase activity GO:0051338 355 0.012
protein modification by small protein removal GO:0070646 92 0.011
mitochondrial respiratory chain complex iv biogenesis GO:0097034 5 0.011
glycosyl compound biosynthetic process GO:1901659 27 0.011
alpha amino acid metabolic process GO:1901605 72 0.011
regulation of growth GO:0040008 165 0.011
Worm
positive regulation of cellular component organization GO:0051130 376 0.011
purine nucleoside triphosphate catabolic process GO:0009146 392 0.011
blood circulation GO:0008015 113 0.011
establishment of protein localization to membrane GO:0090150 121 0.011
multicellular organismal reproductive process GO:0048609 40 0.011
developmental growth GO:0048589 48 0.011
Worm
negative regulation of catalytic activity GO:0043086 335 0.011
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.011
tripartite regional subdivision GO:0007351 2 0.011
nerve development GO:0021675 4 0.011
dna catabolic process endonucleolytic GO:0000737 37 0.010
microtubule based process GO:0007017 210 0.010
ubiquitin dependent protein catabolic process GO:0006511 206 0.010
regulation of protein catabolic process GO:0042176 155 0.010
rna interference GO:0016246 4 0.010
Worm
purine ribonucleotide biosynthetic process GO:0009152 79 0.010
negative regulation of growth GO:0045926 97 0.010
negative regulation of endopeptidase activity GO:0010951 84 0.010
negative regulation of protein modification process GO:0031400 200 0.010
cofactor metabolic process GO:0051186 87 0.010
internal protein amino acid acetylation GO:0006475 101 0.010

EIF2B3 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.347
inherited metabolic disorder DOID:655 242 0.347
leigh disease DOID:3652 16 0.129
mitochondrial metabolism disease DOID:700 29 0.129
neuromuscular disease DOID:440 38 0.014
nervous system disease DOID:863 431 0.014
neuropathy DOID:870 52 0.014
sensory system disease DOID:0050155 203 0.014
acute porphyria DOID:3133 7 0.012
porphyria DOID:13268 8 0.012