Homo sapiens

78 known processes

EIF2C4

eukaryotic translation initiation factor 2C, 4

(Aliases: AGO4)

EIF2C4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
production of mirnas involved in gene silencing by mirna GO:0035196 12 1.000
Human
positive regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay GO:1900153 8 0.996
positive regulation of mrna catabolic process GO:0061014 10 0.994
regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay GO:1900151 8 0.985
positive regulation of nuclear transcribed mrna poly a tail shortening GO:0060213 8 0.924
gene silencing by mirna GO:0035195 23 0.920
regulation of mrna catabolic process GO:0061013 13 0.876
regulation of nuclear transcribed mrna poly a tail shortening GO:0060211 8 0.869
negative regulation of translation involved in gene silencing by mirna GO:0035278 6 0.863
translational initiation GO:0006413 48 0.860
Human
nuclear transcribed mrna catabolic process GO:0000956 48 0.807
Human
regulation of translation ncrna mediated GO:0045974 6 0.802
production of small rna involved in gene silencing by rna GO:0070918 13 0.770
Human
rna catabolic process GO:0006401 71 0.751
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.749
Human
mrna catabolic process GO:0006402 56 0.713
cellular macromolecule catabolic process GO:0044265 380 0.648
negative regulation of protein metabolic process GO:0051248 391 0.621
positive regulation of mrna metabolic process GO:1903313 19 0.613
negative regulation of translation ncrna mediated GO:0040033 6 0.609
nuclear transcribed mrna poly a tail shortening GO:0000289 8 0.538
mrna processing GO:0006397 133 0.521
Human
multicellular organismal aging GO:0010259 3 0.519
rna processing GO:0006396 255 0.517
Human
cellular response to dsrna GO:0071359 19 0.496
Human
positive regulation of mrna 3 end processing GO:0031442 12 0.472
dsrna fragmentation GO:0031050 13 0.465
Human
mrna 3 end processing GO:0031124 24 0.461
posttranscriptional regulation of gene expression GO:0010608 213 0.456
cellular response to nitrogen compound GO:1901699 144 0.449
Human
translation GO:0006412 132 0.443
response to dsrna GO:0043331 25 0.426
Human
determination of adult lifespan GO:0008340 2 0.411
gene silencing by rna GO:0031047 26 0.407
positive regulation of catabolic process GO:0009896 310 0.404
regulation of translation GO:0006417 89 0.397
pre mirna processing GO:0031054 8 0.364
Human
negative regulation of cellular protein metabolic process GO:0032269 353 0.344
mrna cleavage involved in gene silencing by mirna GO:0035279 2 0.331
Human
blastoderm segmentation GO:0007350 2 0.316
mrna metabolic process GO:0016071 175 0.315
cellular response to organic cyclic compound GO:0071407 127 0.275
Human
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.272
regulation of gene expression epigenetic GO:0040029 73 0.268
rna phosphodiester bond hydrolysis GO:0090501 35 0.265
Human
gene silencing GO:0016458 49 0.251
ncrna metabolic process GO:0034660 108 0.244
Human
regulation of stem cell proliferation GO:0072091 15 0.221
Human
posttranscriptional gene silencing GO:0016441 25 0.216
posttranscriptional gene silencing by rna GO:0035194 25 0.199
cellular macromolecular complex assembly GO:0034622 324 0.187
negative regulation of translation GO:0017148 37 0.176
ribonucleoprotein complex biogenesis GO:0022613 116 0.172
regulation of translational initiation GO:0006446 24 0.172
Human
nuclear transcribed mrna catabolic process deadenylation dependent decay GO:0000288 14 0.165
signal transduction by phosphorylation GO:0023014 297 0.157
post embryonic development GO:0009791 2 0.155
positive regulation of cellular catabolic process GO:0031331 284 0.155
cell type specific apoptotic process GO:0097285 125 0.155
response to nitrogen compound GO:1901698 184 0.150
Human
cell development GO:0048468 328 0.142
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.137
embryonic hemopoiesis GO:0035162 4 0.119
single organism cellular localization GO:1902580 332 0.116
positive regulation of organelle organization GO:0010638 195 0.111
ribonucleoprotein complex assembly GO:0022618 78 0.099
positive regulation of developmental process GO:0051094 314 0.096
compound eye development GO:0048749 1 0.094
rna 3 end processing GO:0031123 35 0.091
negative regulation of cell differentiation GO:0045596 171 0.089
negative regulation of translational initiation GO:0045947 7 0.081
Human
cytoplasmic transport GO:0016482 379 0.077
regulation of mrna metabolic process GO:1903311 53 0.077
system process GO:0003008 349 0.075
neuron projection development GO:0031175 106 0.072
regulation of growth GO:0040008 165 0.071
stem cell proliferation GO:0072089 25 0.067
Human
positive regulation of cellular component organization GO:0051130 376 0.066
response to organic cyclic compound GO:0014070 204 0.066
Human
nuclear export GO:0051168 69 0.065
behavior GO:0007610 112 0.064
negative regulation of nuclear transcribed mrna catabolic process nonsense mediated decay GO:2000623 3 0.063
nucleoside phosphate catabolic process GO:1901292 412 0.061
production of sirna involved in rna interference GO:0030422 3 0.061
growth GO:0040007 202 0.060
purine ribonucleoside metabolic process GO:0046128 437 0.059
regulation of cytoplasmic mrna processing body assembly GO:0010603 5 0.058
targeting of mrna for destruction involved in rna interference GO:0030423 3 0.058
cellular response to nutrient levels GO:0031669 69 0.057
cell projection organization GO:0030030 252 0.057
glycosyl compound catabolic process GO:1901658 413 0.053
intracellular protein transport GO:0006886 270 0.052
nucleobase containing compound transport GO:0015931 51 0.051
molting cycle GO:0042303 28 0.051
purine ribonucleotide catabolic process GO:0009154 404 0.051
ribonucleotide catabolic process GO:0009261 405 0.051
segmentation GO:0035282 4 0.049
cell morphogenesis GO:0000902 296 0.049
ncrna processing GO:0034470 83 0.048
Human
nucleoside triphosphate catabolic process GO:0009143 394 0.048
regulation of cellular component biogenesis GO:0044087 281 0.047
positive regulation of mrna processing GO:0050685 17 0.046
rna phosphodiester bond hydrolysis endonucleolytic GO:0090502 15 0.045
Human
negative regulation of apoptotic process GO:0043066 316 0.045
purine nucleoside catabolic process GO:0006152 398 0.044
negative regulation of cell death GO:0060548 345 0.044
regulation of gene silencing by mirna GO:0060964 6 0.042
regulation of cell development GO:0060284 161 0.041
ribonucleoprotein complex localization GO:0071166 4 0.041
negative regulation of programmed cell death GO:0043069 321 0.041
organophosphate catabolic process GO:0046434 430 0.040
amine metabolic process GO:0009308 44 0.039
purine ribonucleoside catabolic process GO:0046130 398 0.039
purine nucleoside triphosphate catabolic process GO:0009146 392 0.038
aging GO:0007568 66 0.038
protein ubiquitination GO:0016567 314 0.038
immune system development GO:0002520 195 0.038
reproductive process GO:0022414 106 0.037
associative learning GO:0008306 1 0.037
hematopoietic or lymphoid organ development GO:0048534 186 0.037
mapk cascade GO:0000165 288 0.036
epithelial cell differentiation GO:0030855 141 0.036
neurological system process GO:0050877 163 0.035
memory GO:0007613 3 0.035
stem cell differentiation GO:0048863 93 0.034
nucleoside triphosphate metabolic process GO:0009141 422 0.034
regulation of cell differentiation GO:0045595 393 0.034
regulation of cellular response to stress GO:0080135 244 0.034
nucleotide catabolic process GO:0009166 408 0.033
locomotory behavior GO:0007626 1 0.033
mrna transport GO:0051028 30 0.033
sex differentiation GO:0007548 45 0.033
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.032
regulation of cellular amino acid metabolic process GO:0006521 6 0.031
cellular amine metabolic process GO:0044106 41 0.030
negative regulation of catalytic activity GO:0043086 335 0.030
developmental process involved in reproduction GO:0003006 66 0.029
rna interference GO:0016246 4 0.029
muscle organ development GO:0007517 56 0.029
ribonucleoside triphosphate catabolic process GO:0009203 391 0.029
purine nucleotide catabolic process GO:0006195 405 0.028
nucleoside catabolic process GO:0009164 408 0.028
positive regulation of nucleotide metabolic process GO:0045981 230 0.028
regulation of cellular ketone metabolic process GO:0010565 50 0.028
purine containing compound catabolic process GO:0072523 411 0.028
atp metabolic process GO:0046034 176 0.028
cellular response to external stimulus GO:0071496 111 0.027
positive regulation of growth GO:0045927 58 0.027
regulation of nucleoside metabolic process GO:0009118 209 0.026
dephosphorylation GO:0016311 209 0.026
ribonucleoside triphosphate metabolic process GO:0009199 412 0.026
negative regulation of multicellular organismal process GO:0051241 317 0.026
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.025
purine nucleoside triphosphate metabolic process GO:0009144 412 0.025
ribonucleoside catabolic process GO:0042454 406 0.025
reproductive system development GO:0061458 56 0.025
regulation of cellular amine metabolic process GO:0033238 11 0.025
endosomal transport GO:0016197 129 0.024
cellular response to starvation GO:0009267 58 0.024
secretion GO:0046903 254 0.024
secretion by cell GO:0032940 226 0.024
hemopoiesis GO:0030097 180 0.024
cellular response to oxygen containing compound GO:1901701 276 0.023
inner ear morphogenesis GO:0042472 4 0.023
adult locomotory behavior GO:0008344 1 0.023
cellular amino acid metabolic process GO:0006520 116 0.023
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.023
regulation of mrna 3 end processing GO:0031440 12 0.022
oogenesis GO:0048477 2 0.022
negative regulation of catabolic process GO:0009895 104 0.021
ribonucleoprotein complex subunit organization GO:0071826 81 0.021
actin filament based process GO:0030029 224 0.021
response to other organism GO:0051707 261 0.021
embryo development GO:0009790 123 0.021
regulation of kinase activity GO:0043549 314 0.021
positive regulation of cell death GO:0010942 263 0.020
microtubule based process GO:0007017 210 0.020
guanosine containing compound catabolic process GO:1901069 239 0.020
negative regulation of phosphate metabolic process GO:0045936 267 0.020
purine nucleoside monophosphate catabolic process GO:0009128 158 0.020
carbohydrate derivative biosynthetic process GO:1901137 207 0.020
regulation of behavior GO:0050795 82 0.020
immune response GO:0006955 307 0.020
nucleocytoplasmic transport GO:0006913 176 0.020
regulation of transferase activity GO:0051338 355 0.020
neuromuscular junction development GO:0007528 3 0.020
response to cytokine GO:0034097 232 0.020
regulation of protein kinase activity GO:0045859 289 0.020
cellular ketone metabolic process GO:0042180 80 0.019
rho protein signal transduction GO:0007266 26 0.019
positive regulation of gtpase activity GO:0043547 166 0.019
motor neuron axon guidance GO:0008045 2 0.019
neuron projection regeneration GO:0031102 1 0.019
negative regulation of phosphorus metabolic process GO:0010563 267 0.019
reactive oxygen species metabolic process GO:0072593 75 0.019
cell morphogenesis involved in differentiation GO:0000904 144 0.018
positive regulation of hydrolase activity GO:0051345 331 0.018
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.018
positive regulation of immune system process GO:0002684 283 0.018
small gtpase mediated signal transduction GO:0007264 78 0.018
nucleoside monophosphate metabolic process GO:0009123 191 0.018
regulation of nucleotide metabolic process GO:0006140 269 0.018
regulation of cell cycle process GO:0010564 266 0.018
cell differentiation in spinal cord GO:0021515 1 0.017
developmental programmed cell death GO:0010623 3 0.017
chromatin organization GO:0006325 351 0.017
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.017
positive regulation of apoptotic process GO:0043065 246 0.017
cellular response to growth factor stimulus GO:0071363 197 0.017
anatomical structure formation involved in morphogenesis GO:0048646 284 0.017
positive regulation of nucleoside metabolic process GO:0045979 186 0.017
protein catabolic process GO:0030163 325 0.017
ribonucleoside monophosphate metabolic process GO:0009161 187 0.017
reactive oxygen species biosynthetic process GO:1903409 4 0.016
dna repair GO:0006281 198 0.016
positive regulation of nucleotide catabolic process GO:0030813 185 0.016
regulation of purine nucleotide metabolic process GO:1900542 264 0.016
single organism carbohydrate metabolic process GO:0044723 193 0.016
mrna export from nucleus GO:0006406 29 0.016
t cell differentiation in thymus GO:0033077 4 0.016
regulation of proteolysis GO:0030162 293 0.016
regulation of anatomical structure morphogenesis GO:0022603 286 0.016
positive regulation of cellular component biogenesis GO:0044089 158 0.016
cerebellum development GO:0021549 2 0.016
regulation of system process GO:0044057 101 0.016
female gamete generation GO:0007292 2 0.016
taxis GO:0042330 157 0.016
rna localization GO:0006403 41 0.015
regulation of nucleotide catabolic process GO:0030811 205 0.015
ion transmembrane transport GO:0034220 338 0.015
regulation of protein stability GO:0031647 87 0.015
transmembrane transport GO:0055085 399 0.015
positive regulation of gtp catabolic process GO:0033126 166 0.015
vesicle mediated transport GO:0016192 371 0.015
neuron remodeling GO:0016322 2 0.015
regulation of developmental growth GO:0048638 30 0.015
atp catabolic process GO:0006200 157 0.015
regulation of nuclear transcribed mrna catabolic process nonsense mediated decay GO:2000622 3 0.015
response to axon injury GO:0048678 1 0.015
ion homeostasis GO:0050801 230 0.014
positive regulation of cellular amine metabolic process GO:0033240 7 0.014
response to growth factor GO:0070848 205 0.014
myeloid cell differentiation GO:0030099 117 0.014
nitrogen compound transport GO:0071705 191 0.014
regulation of gene silencing by rna GO:0060966 6 0.014
glial cell migration GO:0008347 4 0.014
regulation of cell cycle phase transition GO:1901987 126 0.014
regulation of gtpase activity GO:0043087 180 0.014
gtp catabolic process GO:0006184 237 0.014
ubiquitin dependent protein catabolic process GO:0006511 206 0.014
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.014
negative regulation of protein phosphorylation GO:0001933 140 0.014
chemical homeostasis GO:0048878 306 0.014
cellular response to dna damage stimulus GO:0006974 379 0.014
positive regulation of cytoplasmic mrna processing body assembly GO:0010606 4 0.014
cellular response to glucocorticoid stimulus GO:0071385 4 0.014
gtp metabolic process GO:0046039 239 0.014
rhythmic behavior GO:0007622 2 0.014
cellular protein complex assembly GO:0043623 188 0.014
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.014
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.014
regulation of mrna processing GO:0050684 48 0.014
regulation of gtp catabolic process GO:0033124 180 0.014
negative regulation of protein modification process GO:0031400 200 0.014
regulation of purine nucleotide catabolic process GO:0033121 205 0.014
cellular protein catabolic process GO:0044257 261 0.013
actin filament organization GO:0007015 128 0.013
negative regulation of hydrolase activity GO:0051346 182 0.013
purine nucleoside monophosphate metabolic process GO:0009126 186 0.013
single organism reproductive process GO:0044702 98 0.013
ras protein signal transduction GO:0007265 73 0.013
cellular response to cytokine stimulus GO:0071345 181 0.013
cell part morphogenesis GO:0032990 137 0.013
metencephalon development GO:0022037 2 0.013
sex determination GO:0007530 3 0.013
regulation of reactive oxygen species metabolic process GO:2000377 41 0.013
oocyte differentiation GO:0009994 2 0.013
nuclear body organization GO:0030575 4 0.013
cellular response to endogenous stimulus GO:0071495 336 0.013
digestive tract morphogenesis GO:0048546 56 0.013
regulation of secretion by cell GO:1903530 177 0.013
neurotransmitter secretion GO:0007269 4 0.013
negative regulation of transferase activity GO:0051348 124 0.013
cell proliferation in forebrain GO:0021846 1 0.013
response to oxygen containing compound GO:1901700 369 0.013
organophosphate biosynthetic process GO:0090407 163 0.013
biological adhesion GO:0022610 331 0.012
circadian behavior GO:0048512 2 0.012
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.012
regulation of cell projection organization GO:0031344 107 0.012
multicellular organismal reproductive process GO:0048609 40 0.012
modification dependent protein catabolic process GO:0019941 209 0.012
negative regulation of protein processing GO:0010955 142 0.012
nucleoside monophosphate catabolic process GO:0009125 159 0.012
cellular response to extracellular stimulus GO:0031668 72 0.012
cell cycle phase transition GO:0044770 173 0.012
protein maturation GO:0051604 233 0.012
cellular component morphogenesis GO:0032989 314 0.012
cell migration involved in gastrulation GO:0042074 1 0.012
negative regulation of mitotic cell cycle GO:0045930 102 0.012
protein polyubiquitination GO:0000209 110 0.012
endocytosis GO:0006897 159 0.012
regulation of secretion GO:0051046 194 0.012
negative regulation of phosphorylation GO:0042326 174 0.012
multicellular organism reproduction GO:0032504 42 0.012
regeneration GO:0031099 4 0.012
stem cell development GO:0048864 69 0.012
negative regulation of cell cycle GO:0045786 193 0.012
oocyte development GO:0048599 1 0.012
metal ion transport GO:0030001 272 0.012
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.012
protein import GO:0017038 130 0.012
regulation of ras gtpase activity GO:0032318 128 0.012
positive regulation of developmental growth GO:0048639 16 0.012
intracellular receptor signaling pathway GO:0030522 104 0.012
apoptotic signaling pathway GO:0097190 268 0.012
rna transport GO:0050658 39 0.012
positive regulation of phosphorylation GO:0042327 394 0.012
long term memory GO:0007616 2 0.012
ribonucleoside monophosphate catabolic process GO:0009158 158 0.011
enzyme linked receptor protein signaling pathway GO:0007167 303 0.011
regulation of peptidase activity GO:0052547 180 0.011
wnt signaling pathway GO:0016055 156 0.011
positive regulation of protein catabolic process GO:0045732 75 0.011
regulation of synaptic plasticity GO:0048167 3 0.011
protein targeting GO:0006605 187 0.011
regulation of protein serine threonine kinase activity GO:0071900 179 0.011
multi organism reproductive process GO:0044703 54 0.011
regulation of intracellular steroid hormone receptor signaling pathway GO:0033143 32 0.011
regulation of protein processing GO:0070613 150 0.011
cell projection morphogenesis GO:0048858 129 0.011
cellular homeostasis GO:0019725 196 0.011
neuroblast proliferation GO:0007405 4 0.011
convergent extension involved in gastrulation GO:0060027 1 0.011
negative regulation of developmental process GO:0051093 247 0.011
protein modification by small protein conjugation GO:0032446 342 0.011
regulation of protein maturation GO:1903317 150 0.011
cation transport GO:0006812 331 0.011
organonitrogen compound biosynthetic process GO:1901566 200 0.011
intracellular steroid hormone receptor signaling pathway GO:0030518 61 0.011
protein localization to organelle GO:0033365 280 0.011
actin filament based movement GO:0030048 17 0.011
regulation of ras protein signal transduction GO:0046578 155 0.011
negative regulation of cellular catabolic process GO:0031330 83 0.011
mitotic cell cycle phase transition GO:0044772 162 0.011
positive regulation of mapk cascade GO:0043410 190 0.011
maintenance of location GO:0051235 112 0.011
covalent chromatin modification GO:0016569 254 0.011
regulation of organelle assembly GO:1902115 40 0.011
lipid metabolic process GO:0006629 381 0.011
protein processing GO:0016485 226 0.011
regulation of defense response GO:0031347 154 0.011
regulation of cell activation GO:0050865 125 0.011
hindbrain development GO:0030902 3 0.011
axon regeneration GO:0031103 1 0.011
epithelium development GO:0060429 227 0.011
protein targeting to nucleus GO:0044744 104 0.011
protein oligomerization GO:0051259 173 0.011
regulation of cytoskeleton organization GO:0051493 177 0.011
negative regulation of kinase activity GO:0033673 106 0.010
divalent metal ion transport GO:0070838 152 0.010
endoderm formation GO:0001706 33 0.010
leukocyte activation GO:0045321 164 0.010
cellular response to organonitrogen compound GO:0071417 124 0.010
establishment of protein localization to membrane GO:0090150 121 0.010
guanosine containing compound metabolic process GO:1901068 244 0.010
developmental growth GO:0048589 48 0.010
autophagy GO:0006914 88 0.010
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.010
cellular lipid metabolic process GO:0044255 303 0.010
single organism membrane organization GO:0044802 268 0.010
limbic system development GO:0021761 3 0.010
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.010
chromatin modification GO:0016568 298 0.010
lung epithelial cell differentiation GO:0060487 1 0.010
modification dependent macromolecule catabolic process GO:0043632 212 0.010
negative regulation of mrna catabolic process GO:1902373 4 0.010
regulation of protein catabolic process GO:0042176 155 0.010

EIF2C4 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.251
amino acid metabolic disorder DOID:9252 50 0.251
inherited metabolic disorder DOID:655 242 0.251
organic acidemia DOID:0060159 14 0.049
central nervous system disease DOID:331 186 0.021
nervous system disease DOID:863 431 0.021
disease of cellular proliferation DOID:14566 174 0.013
neurodegenerative disease DOID:1289 102 0.012
immune system disease DOID:2914 155 0.012
musculoskeletal system disease DOID:17 223 0.010
sensory system disease DOID:0050155 203 0.010
eye and adnexa disease DOID:1492 150 0.010
eye disease DOID:5614 149 0.010
retinal disease DOID:5679 118 0.010