Homo sapiens

18 known processes

EIF2S2

eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa

(Aliases: EIF2beta,MGC8508,DKFZp686L18198,EIF2,EIF2B)

EIF2S2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of translational initiation in response to stress GO:0043558 1 0.769
translation GO:0006412 132 0.759
post embryonic development GO:0009791 2 0.510
Worm
trna aminoacylation for protein translation GO:0006418 8 0.414
formation of translation preinitiation complex GO:0001731 4 0.412
regulation of translation GO:0006417 89 0.368
cellular amino acid metabolic process GO:0006520 116 0.323
translational initiation GO:0006413 48 0.284
cellular response to dna damage stimulus GO:0006974 379 0.263
oocyte differentiation GO:0009994 2 0.234
amino acid activation GO:0043038 12 0.193
negative regulation of apoptotic process GO:0043066 316 0.182
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.168
ribonucleoprotein complex biogenesis GO:0022613 116 0.168
protein autophosphorylation GO:0046777 123 0.165
posttranscriptional regulation of gene expression GO:0010608 213 0.164
ncrna metabolic process GO:0034660 108 0.161
negative regulation of cell death GO:0060548 345 0.152
oogenesis GO:0048477 2 0.122
negative regulation of cell proliferation GO:0008285 228 0.119
mitotic nuclear division GO:0007067 119 0.115
ribonucleoside triphosphate catabolic process GO:0009203 391 0.113
ribonucleoprotein complex assembly GO:0022618 78 0.111
negative regulation of programmed cell death GO:0043069 321 0.103
positive regulation of cell proliferation GO:0008284 301 0.100
oocyte development GO:0048599 1 0.097
vesicle mediated transport GO:0016192 371 0.094
regulation of endopeptidase activity GO:0052548 170 0.093
hematopoietic or lymphoid organ development GO:0048534 186 0.091
response to organic cyclic compound GO:0014070 204 0.090
cellular response to endogenous stimulus GO:0071495 336 0.090
cellular macromolecule catabolic process GO:0044265 380 0.087
ribonucleoprotein complex subunit organization GO:0071826 81 0.087
regulation of cell differentiation GO:0045595 393 0.086
regulation of translation in response to stress GO:0043555 3 0.084
female gamete generation GO:0007292 2 0.084
negative regulation of catalytic activity GO:0043086 335 0.077
purine containing compound catabolic process GO:0072523 411 0.077
nucleoside catabolic process GO:0009164 408 0.071
regulation of cellular response to stress GO:0080135 244 0.070
regulation of cell development GO:0060284 161 0.070
hematopoietic stem cell differentiation GO:0060218 4 0.069
regulation of translational initiation GO:0006446 24 0.069
signal transduction in response to dna damage GO:0042770 57 0.068
organelle fission GO:0048285 149 0.066
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.066
atp metabolic process GO:0046034 176 0.066
purine nucleoside triphosphate metabolic process GO:0009144 412 0.064
mating GO:0007618 1 0.063
ribonucleoside catabolic process GO:0042454 406 0.063
hemopoiesis GO:0030097 180 0.062
nucleotide catabolic process GO:0009166 408 0.061
negative regulation of protein maturation GO:1903318 142 0.061
apoptotic signaling pathway GO:0097190 268 0.060
regulation of growth GO:0040008 165 0.060
Worm
purine nucleoside catabolic process GO:0006152 398 0.059
positive regulation of apoptotic process GO:0043065 246 0.055
negative regulation of peptidase activity GO:0010466 91 0.054
immune response GO:0006955 307 0.053
negative regulation of endopeptidase activity GO:0010951 84 0.052
negative regulation of hydrolase activity GO:0051346 182 0.052
innate immune response GO:0045087 178 0.052
dna repair GO:0006281 198 0.050
immune effector process GO:0002252 159 0.050
determination of adult lifespan GO:0008340 2 0.050
Worm
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.049
positive regulation of catabolic process GO:0009896 310 0.049
multicellular organismal aging GO:0010259 3 0.049
Worm
positive regulation of response to dna damage stimulus GO:2001022 43 0.048
negative regulation of protein processing GO:0010955 142 0.048
intracellular mrna localization GO:0008298 1 0.046
negative regulation of proteolysis GO:0045861 132 0.044
protein catabolic process GO:0030163 325 0.044
protein processing GO:0016485 226 0.043
regulation of dna metabolic process GO:0051052 153 0.043
regulation of mitotic cell cycle GO:0007346 189 0.042
ribosome biogenesis GO:0042254 48 0.042
anterior posterior axis specification GO:0009948 2 0.042
response to abiotic stimulus GO:0009628 336 0.040
regulation of protein maturation GO:1903317 150 0.040
negative regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043154 46 0.039
mrna metabolic process GO:0016071 175 0.039
regulation of proteolysis GO:0030162 293 0.037
receptor mediated endocytosis GO:0006898 84 0.037
nervous system development GO:0007399 293 0.036
response to virus GO:0009615 126 0.036
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.035
glycosyl compound catabolic process GO:1901658 413 0.035
regulation of cysteine type endopeptidase activity GO:2000116 127 0.034
mitochondrion organization GO:0007005 156 0.034
regulation of response to dna damage stimulus GO:2001020 94 0.034
negative regulation of protein metabolic process GO:0051248 391 0.034
nucleoside phosphate biosynthetic process GO:1901293 109 0.033
positive regulation of nf kappab transcription factor activity GO:0051092 81 0.033
segmentation GO:0035282 4 0.033
purine ribonucleoside catabolic process GO:0046130 398 0.032
regionalization GO:0003002 29 0.032
regulation of cell division GO:0051302 116 0.031
regulation of multi organism process GO:0043900 157 0.031
regulation of protein processing GO:0070613 150 0.031
cellular macromolecular complex assembly GO:0034622 324 0.031
response to other organism GO:0051707 261 0.030
ribonucleoside triphosphate metabolic process GO:0009199 412 0.030
immune system development GO:0002520 195 0.029
locomotory behavior GO:0007626 1 0.029
regulation of cellular amine metabolic process GO:0033238 11 0.029
positive regulation of stress activated protein kinase signaling cascade GO:0070304 61 0.029
ribonucleoside monophosphate metabolic process GO:0009161 187 0.029
regulation of peptidase activity GO:0052547 180 0.029
protein modification by small protein conjugation GO:0032446 342 0.029
cell development GO:0048468 328 0.029
cell division GO:0051301 168 0.028
negative regulation of cysteine type endopeptidase activity GO:2000117 48 0.028
regeneration GO:0031099 4 0.028
nucleoside triphosphate catabolic process GO:0009143 394 0.028
positive regulation of transferase activity GO:0051347 227 0.027
negative regulation of protein modification process GO:0031400 200 0.027
guanosine containing compound catabolic process GO:1901069 239 0.027
gtp catabolic process GO:0006184 237 0.027
cytoplasmic transport GO:0016482 379 0.027
negative regulation of cellular protein metabolic process GO:0032269 353 0.027
nucleoside phosphate catabolic process GO:1901292 412 0.025
cellular response to cytokine stimulus GO:0071345 181 0.025
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.025
maturation of ssu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:0000462 1 0.025
hindbrain development GO:0030902 3 0.024
regulation of cell cycle GO:0051726 393 0.024
endocytosis GO:0006897 159 0.024
positive regulation of hydrolase activity GO:0051345 331 0.024
nuclear division GO:0000280 128 0.024
positive regulation of protein modification by small protein conjugation or removal GO:1903322 61 0.024
regulation of transferase activity GO:0051338 355 0.024
organophosphate catabolic process GO:0046434 430 0.024
purine nucleotide catabolic process GO:0006195 405 0.023
stem cell development GO:0048864 69 0.023
mitotic cell cycle GO:0000278 326 0.023
coenzyme metabolic process GO:0006732 65 0.023
cell cycle checkpoint GO:0000075 117 0.023
defense response GO:0006952 315 0.023
nuclear export GO:0051168 69 0.023
trna aminoacylation GO:0043039 12 0.023
response to radiation GO:0009314 151 0.023
cellular response to growth factor stimulus GO:0071363 197 0.022
positive regulation of programmed cell death GO:0043068 249 0.022
regulation of intracellular transport GO:0032386 195 0.022
positive regulation of nucleotide catabolic process GO:0030813 185 0.022
regulation of pathway restricted smad protein phosphorylation GO:0060393 34 0.022
regulation of protein ubiquitination GO:0031396 95 0.022
cellular protein complex assembly GO:0043623 188 0.022
positive regulation of cytokine production GO:0001819 167 0.022
macromolecular complex disassembly GO:0032984 60 0.022
regulation of cell cycle process GO:0010564 266 0.021
embryo development GO:0009790 123 0.021
Mouse Worm
cellular response to organonitrogen compound GO:0071417 124 0.021
positive regulation of cellular catabolic process GO:0031331 284 0.021
lymphocyte activation GO:0046649 133 0.021
anterior posterior axis specification embryo GO:0008595 2 0.021
reproduction GO:0000003 63 0.021
Mouse Worm
nuclear transport GO:0051169 179 0.021
response to nitrogen compound GO:1901698 184 0.021
alpha amino acid metabolic process GO:1901605 72 0.021
maintenance of location GO:0051235 112 0.020
rna localization GO:0006403 41 0.020
regulation of anatomical structure morphogenesis GO:0022603 286 0.020
negative regulation of cell cycle phase transition GO:1901988 89 0.019
cellular response to abiotic stimulus GO:0071214 117 0.019
cytokine production GO:0001816 247 0.019
purine ribonucleotide catabolic process GO:0009154 404 0.019
anatomical structure formation involved in morphogenesis GO:0048646 284 0.019
ribosomal small subunit biogenesis GO:0042274 13 0.019
proteasomal protein catabolic process GO:0010498 176 0.018
regulation of apoptotic signaling pathway GO:2001233 175 0.018
negative regulation of phosphatase activity GO:0010923 61 0.018
positive regulation of ras gtpase activity GO:0032320 117 0.018
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.018
leukocyte activation GO:0045321 164 0.018
mrna processing GO:0006397 133 0.018
rna transport GO:0050658 39 0.018
blastoderm segmentation GO:0007350 2 0.018
cell morphogenesis GO:0000902 296 0.018
guanosine containing compound metabolic process GO:1901068 244 0.018
regulation of locomotion GO:0040012 329 0.018
positive regulation of ligase activity GO:0051351 19 0.018
response to oxygen containing compound GO:1901700 369 0.017
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.017
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.017
cellular amine metabolic process GO:0044106 41 0.017
vasculature development GO:0001944 181 0.017
regulation of mrna metabolic process GO:1903311 53 0.017
dna recombination GO:0006310 77 0.016
protein ubiquitination GO:0016567 314 0.016
regulation of protein binding GO:0043393 66 0.016
signal transduction by phosphorylation GO:0023014 297 0.016
negative regulation of developmental process GO:0051093 247 0.016
regulation of epithelial cell proliferation GO:0050678 113 0.016
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.016
ras protein signal transduction GO:0007265 73 0.016
regulation of defense response GO:0031347 154 0.016
nucleoside triphosphate metabolic process GO:0009141 422 0.016
cell cell signaling GO:0007267 155 0.016
nucleobase containing compound transport GO:0015931 51 0.016
amine metabolic process GO:0009308 44 0.016
response to wounding GO:0009611 168 0.015
negative regulation of phosphorus metabolic process GO:0010563 267 0.015
tripartite regional subdivision GO:0007351 2 0.015
organelle assembly GO:0070925 176 0.015
dna damage response signal transduction by p53 class mediator GO:0030330 44 0.015
divalent inorganic cation homeostasis GO:0072507 136 0.015
ossification GO:0001503 121 0.015
cellular protein catabolic process GO:0044257 261 0.015
dorsal ventral pattern formation GO:0009953 15 0.015
lipid localization GO:0010876 106 0.014
nucleoside monophosphate metabolic process GO:0009123 191 0.014
signal transduction by p53 class mediator GO:0072331 72 0.014
posttranscriptional gene silencing by rna GO:0035194 25 0.014
motor neuron axon guidance GO:0008045 2 0.014
positive regulation of immune system process GO:0002684 283 0.014
regulation of small gtpase mediated signal transduction GO:0051056 156 0.014
positive regulation of developmental process GO:0051094 314 0.014
Worm
negative regulation of cell cycle process GO:0010948 121 0.014
negative regulation of cell differentiation GO:0045596 171 0.014
endomembrane system organization GO:0010256 196 0.014
apoptotic mitochondrial changes GO:0008637 57 0.013
regulation of dephosphorylation GO:0035303 96 0.013
spindle elongation GO:0051231 4 0.013
response to purine containing compound GO:0014074 40 0.013
organophosphate biosynthetic process GO:0090407 163 0.013
actin filament based process GO:0030029 224 0.013
regulation of protein serine threonine kinase activity GO:0071900 179 0.013
establishment of organelle localization GO:0051656 59 0.013
mitotic cell cycle process GO:1903047 286 0.013
dna replication GO:0006260 116 0.013
stress activated mapk cascade GO:0051403 93 0.013
positive regulation of cell death GO:0010942 263 0.013
gene silencing GO:0016458 49 0.013
negative regulation of intracellular signal transduction GO:1902532 183 0.013
cellular response to organic cyclic compound GO:0071407 127 0.013
single organism cellular localization GO:1902580 332 0.012
cell activation GO:0001775 213 0.012
regulation of dna repair GO:0006282 47 0.012
positive regulation of cell differentiation GO:0045597 211 0.012
cell cycle phase transition GO:0044770 173 0.012
negative regulation of transferase activity GO:0051348 124 0.012
positive regulation of protein catabolic process GO:0045732 75 0.012
ribonucleotide catabolic process GO:0009261 405 0.012
ubiquitin dependent protein catabolic process GO:0006511 206 0.012
regulation of cell growth GO:0001558 135 0.012
regulation of cytokine production GO:0001817 232 0.012
epithelial cell differentiation GO:0030855 141 0.012
regulation of protein kinase activity GO:0045859 289 0.012
regulation of protein catabolic process GO:0042176 155 0.012
dephosphorylation GO:0016311 209 0.012
regulation of immune response GO:0050776 201 0.012
maturation of 5 8s rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:0000466 2 0.012
rhythmic behavior GO:0007622 2 0.012
spermatid differentiation GO:0048515 4 0.012
chemotaxis GO:0006935 157 0.012
cytokine mediated signaling pathway GO:0019221 109 0.012
regulation of cell morphogenesis GO:0022604 153 0.011
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.011
negative regulation of multicellular organismal process GO:0051241 317 0.011
regulation of response to external stimulus GO:0032101 222 0.011
cellular modified amino acid metabolic process GO:0006575 64 0.011
positive regulation of transport GO:0051050 336 0.011
cation transport GO:0006812 331 0.011
cellular response to oxygen containing compound GO:1901701 276 0.011
regulation of gtpase activity GO:0043087 180 0.011
purine nucleoside monophosphate metabolic process GO:0009126 186 0.011
negative regulation of cellular component organization GO:0051129 235 0.011
cell growth GO:0016049 160 0.011
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.011
rna interference GO:0016246 4 0.011
atp catabolic process GO:0006200 157 0.011
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 0.011
single organism membrane organization GO:0044802 268 0.011
meiosis i GO:0007127 4 0.011
positive regulation of intracellular protein transport GO:0090316 76 0.011
regulation of endodeoxyribonuclease activity GO:0032071 3 0.011
negative regulation of phosphate metabolic process GO:0045936 267 0.010
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.010
protein maturation GO:0051604 233 0.010
cell projection organization GO:0030030 252 0.010
pattern specification process GO:0007389 43 0.010
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.010
dna catabolic process GO:0006308 49 0.010
cellular response to nitrogen compound GO:1901699 144 0.010
regulation of phosphatase activity GO:0010921 81 0.010
regulation of nuclear division GO:0051783 65 0.010
negative regulation of cell motility GO:2000146 104 0.010
mitotic cell cycle checkpoint GO:0007093 68 0.010
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.010

EIF2S2 disease predictions

Disease DO term ID Size Probability Func Analog Org
neuromuscular disease DOID:440 38 0.040
nervous system disease DOID:863 431 0.040
neuropathy DOID:870 52 0.040
disease of metabolism DOID:0014667 295 0.026
cancer DOID:162 167 0.019
disease of cellular proliferation DOID:14566 174 0.019
organ system cancer DOID:0050686 164 0.019
central nervous system disease DOID:331 186 0.014
inherited metabolic disorder DOID:655 242 0.014
musculoskeletal system disease DOID:17 223 0.010