Homo sapiens

56 known processes

EIF4E

eukaryotic translation initiation factor 4E

(Aliases: EIF4E1,MGC111573,CBP,EIF4F,EIF4EL1)

EIF4E biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
translational initiation GO:0006413 48 0.971
mitotic cell cycle process GO:1903047 286 0.799
posttranscriptional regulation of gene expression GO:0010608 213 0.712
regulation of translation GO:0006417 89 0.650
positive regulation of cell cycle GO:0045787 140 0.644
determination of adult lifespan GO:0008340 2 0.617
Worm
g1 s transition of mitotic cell cycle GO:0000082 78 0.534
response to organonitrogen compound GO:0010243 156 0.487
regulation of transferase activity GO:0051338 355 0.444
cellular response to nitrogen compound GO:1901699 144 0.440
protein localization to membrane GO:0072657 160 0.434
regulation of proteolysis GO:0030162 293 0.432
cellular response to hormone stimulus GO:0032870 125 0.413
protein import into mitochondrial matrix GO:0030150 1 0.398
mitotic cell cycle GO:0000278 326 0.391
organonitrogen compound biosynthetic process GO:1901566 200 0.388
regulation of cell cycle GO:0051726 393 0.378
cellular amine metabolic process GO:0044106 41 0.370
cellular macromolecule catabolic process GO:0044265 380 0.326
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.304
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.282
neuromuscular junction development GO:0007528 3 0.281
negative regulation of catalytic activity GO:0043086 335 0.278
multicellular organismal aging GO:0010259 3 0.278
Worm
aging GO:0007568 66 0.269
Worm
positive regulation of proteolysis GO:0045862 142 0.255
growth GO:0040007 202 0.253
Fly
mitotic nuclear division GO:0007067 119 0.253
Fly
amine metabolic process GO:0009308 44 0.246
microtubule based process GO:0007017 210 0.227
Fly
regulation of cellular component biogenesis GO:0044087 281 0.223
meiotic chromosome segregation GO:0045132 4 0.218
Worm Fly
regeneration GO:0031099 4 0.216
protein processing GO:0016485 226 0.214
single organism cellular localization GO:1902580 332 0.213
negative regulation of cellular component organization GO:0051129 235 0.204
response to peptide GO:1901652 65 0.202
cellular response to dna damage stimulus GO:0006974 379 0.200
negative regulation of transferase activity GO:0051348 124 0.198
negative regulation of protein metabolic process GO:0051248 391 0.197
chromosome segregation GO:0007059 114 0.178
Worm Fly
somitogenesis GO:0001756 2 0.172
cell cycle g1 s phase transition GO:0044843 80 0.171
small molecule biosynthetic process GO:0044283 157 0.170
cellular response to oxygen containing compound GO:1901701 276 0.167
epithelium development GO:0060429 227 0.164
negative regulation of phosphorylation GO:0042326 174 0.158
regulation of kinase activity GO:0043549 314 0.158
positive regulation of hydrolase activity GO:0051345 331 0.157
negative regulation of protein processing GO:0010955 142 0.138
negative regulation of phosphorus metabolic process GO:0010563 267 0.134
modification dependent protein catabolic process GO:0019941 209 0.131
negative regulation of kinase activity GO:0033673 106 0.129
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.126
regulation of mitotic cell cycle GO:0007346 189 0.125
response to nitrogen compound GO:1901698 184 0.123
female gamete generation GO:0007292 2 0.122
Worm
sulfur compound biosynthetic process GO:0044272 38 0.122
positive regulation of peptidase activity GO:0010952 88 0.118
tube development GO:0035295 125 0.116
single organism membrane organization GO:0044802 268 0.115
protein maturation GO:0051604 233 0.114
tor signaling GO:0031929 39 0.114
negative regulation of phosphate metabolic process GO:0045936 267 0.112
regulation of translational initiation GO:0006446 24 0.111
response to hormone GO:0009725 175 0.111
neuron differentiation GO:0030182 138 0.110
positive regulation of cellular amine metabolic process GO:0033240 7 0.106
nuclear division GO:0000280 128 0.105
Worm Fly
coenzyme metabolic process GO:0006732 65 0.105
response to peptide hormone GO:0043434 61 0.099
regulation of cysteine type endopeptidase activity GO:2000116 127 0.099
regulation of cellular ketone metabolic process GO:0010565 50 0.099
sulfur compound metabolic process GO:0006790 101 0.098
negative regulation of cellular protein metabolic process GO:0032269 353 0.095
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.094
mrna metabolic process GO:0016071 175 0.093
mapk cascade GO:0000165 288 0.091
locomotory behavior GO:0007626 1 0.090
apoptotic signaling pathway GO:0097190 268 0.090
protein catabolic process GO:0030163 325 0.090
response to amino acid GO:0043200 14 0.089
regulation of cellular amine metabolic process GO:0033238 11 0.088
negative regulation of cell proliferation GO:0008285 228 0.087
neuron development GO:0048666 113 0.085
cell morphogenesis GO:0000902 296 0.083
positive regulation of catabolic process GO:0009896 310 0.083
regulation of proteasomal protein catabolic process GO:0061136 87 0.083
regulation of cellular component movement GO:0051270 334 0.082
insulin receptor signaling pathway GO:0008286 23 0.081
camp mediated signaling GO:0019933 23 0.080
modification dependent macromolecule catabolic process GO:0043632 212 0.079
cell development GO:0048468 328 0.079
Worm Fly
positive regulation of organelle organization GO:0010638 195 0.078
rna splicing via transesterification reactions GO:0000375 90 0.078
cellular response to peptide hormone stimulus GO:0071375 56 0.077
regulation of response to external stimulus GO:0032101 222 0.074
organophosphate biosynthetic process GO:0090407 163 0.073
stress activated protein kinase signaling cascade GO:0031098 94 0.072
generation of neurons GO:0048699 152 0.072
regulation of map kinase activity GO:0043405 108 0.072
regulation of cell migration GO:0030334 289 0.072
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.071
regulation of stress activated mapk cascade GO:0032872 84 0.071
enzyme linked receptor protein signaling pathway GO:0007167 303 0.070
mrna processing GO:0006397 133 0.070
regulation of protein localization GO:0032880 296 0.069
proteasomal protein catabolic process GO:0010498 176 0.069
establishment of organelle localization GO:0051656 59 0.069
lipid metabolic process GO:0006629 381 0.068
regulation of cellular amino acid metabolic process GO:0006521 6 0.066
cytoplasmic translational initiation GO:0002183 6 0.063
cellular response to organonitrogen compound GO:0071417 124 0.062
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.062
intrinsic apoptotic signaling pathway GO:0097193 127 0.062
spermidine metabolic process GO:0008216 3 0.061
negative regulation of cell death GO:0060548 345 0.061
cellular ketone metabolic process GO:0042180 80 0.061
organic anion transport GO:0015711 103 0.060
transmembrane transport GO:0055085 399 0.060
autophagy GO:0006914 88 0.060
secretion GO:0046903 254 0.059
peptidyl serine phosphorylation GO:0018105 101 0.059
signal transduction by phosphorylation GO:0023014 297 0.059
microtubule cytoskeleton organization GO:0000226 176 0.059
Fly
regulation of protein serine threonine kinase activity GO:0071900 179 0.057
post embryonic development GO:0009791 2 0.057
Fly
oogenesis GO:0048477 2 0.056
Worm
morphogenesis of embryonic epithelium GO:0016331 4 0.056
regulation of endopeptidase activity GO:0052548 170 0.056
mrna splicing via spliceosome GO:0000398 89 0.056
segmentation GO:0035282 4 0.055
regulation of cell motility GO:2000145 299 0.054
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.054
regulation of mapk cascade GO:0043408 262 0.052
cellular protein catabolic process GO:0044257 261 0.051
regulation of peptidase activity GO:0052547 180 0.051
cellular response to peptide GO:1901653 59 0.050
positive regulation of developmental process GO:0051094 314 0.050
actin cytoskeleton organization GO:0030036 207 0.049
positive regulation of cell death GO:0010942 263 0.046
positive regulation of endopeptidase activity GO:0010950 84 0.045
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.045
cellular response to endogenous stimulus GO:0071495 336 0.045
interspecies interaction between organisms GO:0044419 156 0.045
positive regulation of phosphorylation GO:0042327 394 0.045
vesicle mediated transport GO:0016192 371 0.044
negative regulation of protein serine threonine kinase activity GO:0071901 57 0.044
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.044
regulation of cellular protein catabolic process GO:1903362 96 0.043
behavior GO:0007610 112 0.043
actin filament organization GO:0007015 128 0.043
regulation of cell development GO:0060284 161 0.042
maintenance of protein location GO:0045185 57 0.042
nervous system development GO:0007399 293 0.042
Fly
response to wounding GO:0009611 168 0.040
negative regulation of mapk cascade GO:0043409 56 0.040
plasma membrane organization GO:0007009 115 0.039
positive regulation of apoptotic process GO:0043065 246 0.039
translation GO:0006412 132 0.039
response to insulin GO:0032868 45 0.039
lipid biosynthetic process GO:0008610 177 0.038
maintenance of location GO:0051235 112 0.038
Worm
ribonucleotide biosynthetic process GO:0009260 81 0.037
negative regulation of cellular catabolic process GO:0031330 83 0.037
negative regulation of establishment of protein localization to plasma membrane GO:0090005 9 0.036
cytoplasmic translation GO:0002181 8 0.036
dephosphorylation GO:0016311 209 0.036
negative regulation of protein phosphorylation GO:0001933 140 0.035
cellular protein complex assembly GO:0043623 188 0.035
signal transduction by p53 class mediator GO:0072331 72 0.035
cellular amino acid metabolic process GO:0006520 116 0.035
digestive tract development GO:0048565 75 0.034
jnk cascade GO:0007254 80 0.034
spermatid differentiation GO:0048515 4 0.034
Worm
negative regulation of protein maturation GO:1903318 142 0.034
purine nucleotide biosynthetic process GO:0006164 84 0.033
rna processing GO:0006396 255 0.033
reproductive process GO:0022414 106 0.033
Worm
organic hydroxy compound metabolic process GO:1901615 147 0.032
mitotic cell cycle phase transition GO:0044772 162 0.031
peptidyl lysine acetylation GO:0018394 101 0.031
response to oxygen containing compound GO:1901700 369 0.030
negative regulation of protein modification process GO:0031400 200 0.030
nitrogen compound transport GO:0071705 191 0.030
positive regulation of cell migration GO:0030335 172 0.030
cell projection organization GO:0030030 252 0.029
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 89 0.029
cellular biogenic amine metabolic process GO:0006576 34 0.029
syncytium formation by plasma membrane fusion GO:0000768 2 0.029
neuron projection development GO:0031175 106 0.029
response to starvation GO:0042594 59 0.028
negative regulation of peptidase activity GO:0010466 91 0.027
protein export from nucleus GO:0006611 29 0.027
signal transduction in response to dna damage GO:0042770 57 0.026
second messenger mediated signaling GO:0019932 78 0.026
ras protein signal transduction GO:0007265 73 0.026
regulation of lipid metabolic process GO:0019216 96 0.026
ubiquitin dependent protein catabolic process GO:0006511 206 0.026
regulation of protein complex assembly GO:0043254 147 0.026
regulation of cell growth GO:0001558 135 0.025
Fly
regulation of apoptotic signaling pathway GO:2001233 175 0.025
oocyte differentiation GO:0009994 2 0.025
Worm
regulation of cellular response to growth factor stimulus GO:0090287 76 0.025
cellular component morphogenesis GO:0032989 314 0.025
regulation of cellular response to stress GO:0080135 244 0.024
positive regulation of programmed cell death GO:0043068 249 0.024
response to nutrient levels GO:0031667 81 0.024
response to alcohol GO:0097305 64 0.024
response to tumor necrosis factor GO:0034612 76 0.024
cell cycle phase transition GO:0044770 173 0.024
somatic muscle development GO:0007525 1 0.024
negative regulation of protein complex assembly GO:0031333 43 0.024
muscle contraction GO:0006936 73 0.024
regulation of nuclear division GO:0051783 65 0.023
negative regulation of hydrolase activity GO:0051346 182 0.023
regulation of rna splicing GO:0043484 62 0.023
regulation of locomotion GO:0040012 329 0.023
small gtpase mediated signal transduction GO:0007264 78 0.023
secretion by cell GO:0032940 226 0.023
positive regulation of cellular catabolic process GO:0031331 284 0.023
protein polyubiquitination GO:0000209 110 0.022
negative regulation of multi organism process GO:0043901 92 0.022
regulation of chromosome organization GO:0033044 103 0.022
cellular response to nutrient levels GO:0031669 69 0.022
neurogenesis GO:0022008 169 0.022
Fly
positive regulation of cell cycle process GO:0090068 106 0.022
regulation of cytoskeleton organization GO:0051493 177 0.022
activation of cysteine type endopeptidase activity GO:0097202 57 0.022
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 42 0.021
positive regulation of mitotic cell cycle GO:0045931 60 0.021
negative regulation of lipid metabolic process GO:0045833 38 0.021
negative regulation of cellular amine metabolic process GO:0033239 3 0.021
peripheral nervous system development GO:0007422 2 0.021
protein localization to plasma membrane GO:0072659 93 0.021
myoblast fusion GO:0007520 1 0.021
response to axon injury GO:0048678 1 0.021
regulation of neuron projection development GO:0010975 57 0.021
regulation of establishment of protein localization GO:0070201 242 0.021
cell growth GO:0016049 160 0.021
Fly
regulation of purine nucleotide biosynthetic process GO:1900371 50 0.020
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.020
regulation of protein catabolic process GO:0042176 155 0.020
regulation of secretion by cell GO:1903530 177 0.020
methionine metabolic process GO:0006555 5 0.020
positive regulation of cell motility GO:2000147 177 0.020
synaptic transmission cholinergic GO:0007271 2 0.020
coenzyme biosynthetic process GO:0009108 24 0.019
actin filament based process GO:0030029 224 0.019
organelle localization GO:0051640 84 0.019
regulation of homeostatic process GO:0032844 121 0.019
negative regulation of stress activated protein kinase signaling cascade GO:0070303 19 0.019
developmental process involved in reproduction GO:0003006 66 0.018
Worm
regulation of growth GO:0040008 165 0.018
Fly
regulation of transcription by chromatin organization GO:0034401 1 0.018
protein acylation GO:0043543 138 0.018
response to biotic stimulus GO:0009607 276 0.018
biological adhesion GO:0022610 331 0.018
negative regulation of map kinase activity GO:0043407 27 0.018
regulation of excitatory postsynaptic membrane potential GO:0060079 1 0.018
organic acid biosynthetic process GO:0016053 97 0.018
developmental growth GO:0048589 48 0.018
regulation of cell projection organization GO:0031344 107 0.018
lipid localization GO:0010876 106 0.017
Worm
positive regulation of transferase activity GO:0051347 227 0.017
cellular response to cytokine stimulus GO:0071345 181 0.017
cellular carbohydrate metabolic process GO:0044262 84 0.017
protein modification by small protein conjugation GO:0032446 342 0.017
extrinsic apoptotic signaling pathway GO:0097191 119 0.017
ion transmembrane transport GO:0034220 338 0.017
anatomical structure formation involved in morphogenesis GO:0048646 284 0.017
sister chromatid segregation GO:0000819 54 0.017
Fly
morphogenesis of an epithelium GO:0002009 60 0.017
organ morphogenesis GO:0009887 147 0.017
Fly
associative learning GO:0008306 1 0.017
positive regulation of tor signaling GO:0032008 11 0.017
cell morphogenesis involved in differentiation GO:0000904 144 0.016
protein polymerization GO:0051258 71 0.016
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.016
stress activated mapk cascade GO:0051403 93 0.016
multicellular organismal reproductive process GO:0048609 40 0.016
Worm
internal peptidyl lysine acetylation GO:0018393 97 0.016
metaphase anaphase transition of cell cycle GO:0044784 21 0.016
protein alkylation GO:0008213 74 0.016
nucleotide biosynthetic process GO:0009165 109 0.016
purine containing compound biosynthetic process GO:0072522 88 0.016
positive regulation of locomotion GO:0040017 186 0.016
nucleoside triphosphate metabolic process GO:0009141 422 0.016
nucleoside phosphate biosynthetic process GO:1901293 109 0.016
cell projection morphogenesis GO:0048858 129 0.016
positive regulation of dna metabolic process GO:0051054 73 0.015
negative regulation of apoptotic process GO:0043066 316 0.015
regulation of nervous system development GO:0051960 88 0.015
peptidyl serine modification GO:0018209 106 0.015
hexose metabolic process GO:0019318 55 0.015
regulation of neuron differentiation GO:0045664 70 0.015
response to external biotic stimulus GO:0043207 261 0.015
regulation of protein kinase activity GO:0045859 289 0.015
regulation of transmembrane transport GO:0034762 139 0.015
single organism carbohydrate metabolic process GO:0044723 193 0.015
regulation of ion transmembrane transporter activity GO:0032412 72 0.015
microtubule organizing center organization GO:0031023 62 0.015
response to drug GO:0042493 81 0.014
response to virus GO:0009615 126 0.014
spindle organization GO:0007051 53 0.014
Fly
regulation of response to wounding GO:1903034 101 0.014
centrosome organization GO:0051297 58 0.014
ribonucleoprotein complex biogenesis GO:0022613 116 0.014
positive regulation of ligase activity GO:0051351 19 0.014
wound healing GO:0042060 115 0.014
embryo development GO:0009790 123 0.014
Worm Fly
nls bearing protein import into nucleus GO:0006607 2 0.014
cell division GO:0051301 168 0.014
regulation of jnk cascade GO:0046328 73 0.014
maintenance of protein location in cell GO:0032507 56 0.014
negative regulation of transport GO:0051051 176 0.014
lipid storage GO:0019915 28 0.014
Worm
nucleotide catabolic process GO:0009166 408 0.014
cell morphogenesis involved in neuron differentiation GO:0048667 44 0.014
ribosome biogenesis GO:0042254 48 0.013
regulation of protein maturation GO:1903317 150 0.013
microtubule anchoring GO:0034453 24 0.013
cell adhesion GO:0007155 325 0.013
cation transmembrane transport GO:0098655 238 0.013
nucleoside catabolic process GO:0009164 408 0.013
regionalization GO:0003002 29 0.013
oocyte development GO:0048599 1 0.013
Worm
response to ketone GO:1901654 19 0.013
inorganic ion transmembrane transport GO:0098660 231 0.013
glycosyl compound catabolic process GO:1901658 413 0.013
organelle assembly GO:0070925 176 0.013
nucleoside triphosphate catabolic process GO:0009143 394 0.013
regulation of cell cycle process GO:0010564 266 0.013
protein targeting GO:0006605 187 0.013
canonical wnt signaling pathway GO:0060070 116 0.012
cytokine production GO:0001816 247 0.012
protein methylation GO:0006479 74 0.012
negative regulation of multicellular organismal process GO:0051241 317 0.012
actin filament bundle organization GO:0061572 54 0.012
negative regulation of proteolysis GO:0045861 132 0.012
response to ethanol GO:0045471 11 0.012
establishment of protein localization to membrane GO:0090150 121 0.012
cell part morphogenesis GO:0032990 137 0.012
carboxylic acid biosynthetic process GO:0046394 97 0.012
positive regulation of developmental growth GO:0048639 16 0.012
cellular response to insulin stimulus GO:0032869 41 0.012
regulation of cell morphogenesis GO:0022604 153 0.012
negative regulation of catabolic process GO:0009895 104 0.012
nuclear export GO:0051168 69 0.012
postsynaptic membrane organization GO:0001941 2 0.012
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.012
spindle assembly GO:0051225 29 0.012
regulation of lipid kinase activity GO:0043550 19 0.012
regulation of autophagy GO:0010506 52 0.012
mesenchymal cell development GO:0014031 50 0.012
anion transport GO:0006820 161 0.012
regulation of cellular component size GO:0032535 82 0.012
negative regulation of response to external stimulus GO:0032102 83 0.012
regulation of ion transmembrane transport GO:0034765 132 0.011
positive regulation of cell development GO:0010720 92 0.011
defense response to other organism GO:0098542 129 0.011
methylation GO:0032259 106 0.011
regulation of cell division GO:0051302 116 0.011
dna catabolic process GO:0006308 49 0.011
establishment of chromosome localization GO:0051303 20 0.011
cell cell signaling GO:0007267 155 0.011
mesoderm development GO:0007498 14 0.011
response to interleukin 1 GO:0070555 47 0.011
regulation of ligase activity GO:0051340 29 0.011
pattern specification process GO:0007389 43 0.011
establishment of epithelial cell polarity GO:0090162 2 0.011
wnt signaling pathway GO:0016055 156 0.011
cytoplasmic transport GO:0016482 379 0.011
single fertilization GO:0007338 11 0.011
negative regulation of jnk cascade GO:0046329 16 0.011
sulfur amino acid metabolic process GO:0000096 14 0.011
amine biosynthetic process GO:0009309 4 0.011
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.011
negative regulation of intracellular signal transduction GO:1902532 183 0.011
response to oxidative stress GO:0006979 121 0.011
carbohydrate biosynthetic process GO:0016051 42 0.011
negative regulation of programmed cell death GO:0043069 321 0.011
epithelial cell proliferation GO:0050673 128 0.011
intracellular protein transport GO:0006886 270 0.011
single organism cell adhesion GO:0098602 179 0.011
signal release GO:0023061 70 0.011
cognition GO:0050890 43 0.011
oxidation reduction process GO:0055114 396 0.010
regulation of mrna metabolic process GO:1903311 53 0.010
neural tube formation GO:0001841 3 0.010
regulation of metaphase anaphase transition of cell cycle GO:1902099 26 0.010
positive regulation of chromosome organization GO:2001252 41 0.010
regulation of sister chromatid segregation GO:0033045 27 0.010
positive regulation of cell size GO:0045793 3 0.010
reproduction GO:0000003 63 0.010
Worm Fly
response to inorganic substance GO:0010035 127 0.010
response to organic cyclic compound GO:0014070 204 0.010
dendrite development GO:0016358 24 0.010
purine containing compound catabolic process GO:0072523 411 0.010
regulation of protein processing GO:0070613 150 0.010
negative regulation of endopeptidase activity GO:0010951 84 0.010

EIF4E disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.066
inherited metabolic disorder DOID:655 242 0.055
congenital disorder of glycosylation type i DOID:0050570 16 0.013
carbohydrate metabolic disorder DOID:2978 55 0.013
congenital disorder of glycosylation DOID:5212 26 0.013
central nervous system disease DOID:331 186 0.010
nervous system disease DOID:863 431 0.010
disease of mental health DOID:150 70 0.002
developmental disorder of mental health DOID:0060037 29 0.002
autistic disorder DOID:12849 9 0.001
pervasive developmental disorder DOID:0060040 10 0.001
autism spectrum disorder DOID:0060041 9 0.001