|
|
peptidyl tyrosine modification
|
GO:0018212 |
170 |
0.987
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
41 |
0.921
|
|
|
|
cellular response to peptide hormone stimulus
|
GO:0071375 |
56 |
0.917
|
|
|
|
response to oxygen containing compound
|
GO:1901700 |
369 |
0.913
|
|
|
|
cell type specific apoptotic process
|
GO:0097285 |
125 |
0.890
|
Rat |
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.869
|
|
|
|
response to lipid
|
GO:0033993 |
206 |
0.824
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
6 |
0.822
|
|
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.815
|
|
|
|
peptidyl tyrosine phosphorylation
|
GO:0018108 |
170 |
0.788
|
|
|
|
cellular response to oxygen containing compound
|
GO:1901701 |
276 |
0.780
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
11 |
0.772
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
80 |
0.752
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.744
|
|
|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
181 |
0.737
|
|
|
|
cellular response to growth hormone stimulus
|
GO:0071378 |
10 |
0.735
|
|
|
|
cellular response to nitrogen compound
|
GO:1901699 |
144 |
0.725
|
|
|
|
positive regulation of cell differentiation
|
GO:0045597 |
211 |
0.704
|
|
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
391 |
0.679
|
|
|
|
response to estradiol
|
GO:0032355 |
23 |
0.673
|
|
|
|
regulation of proteasomal protein catabolic process
|
GO:0061136 |
87 |
0.670
|
|
|
|
cellular response to organonitrogen compound
|
GO:0071417 |
124 |
0.664
|
|
|
|
enzyme linked receptor protein signaling pathway
|
GO:0007167 |
303 |
0.663
|
|
|
|
response to hormone
|
GO:0009725 |
175 |
0.657
|
|
|
|
regulation of jak stat cascade
|
GO:0046425 |
44 |
0.656
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.655
|
|
|
|
regulation of cytokine production
|
GO:0001817 |
232 |
0.646
|
|
|
|
tyrosine phosphorylation of stat protein
|
GO:0007260 |
33 |
0.639
|
|
|
|
response to growth hormone
|
GO:0060416 |
11 |
0.638
|
|
|
|
negative regulation of myeloid cell differentiation
|
GO:0045638 |
42 |
0.635
|
|
|
|
regulation of leukocyte differentiation
|
GO:1902105 |
61 |
0.633
|
|
|
|
negative regulation of developmental process
|
GO:0051093 |
247 |
0.601
|
|
|
|
negative regulation of multicellular organismal process
|
GO:0051241 |
317 |
0.580
|
|
|
|
response to estrogen
|
GO:0043627 |
47 |
0.577
|
|
|
|
positive regulation of cytosolic calcium ion concentration
|
GO:0007204 |
82 |
0.559
|
Rat |
|
|
cation transport
|
GO:0006812 |
331 |
0.546
|
|
|
|
cd8 positive alpha beta t cell activation
|
GO:0036037 |
3 |
0.538
|
|
|
|
cellular divalent inorganic cation homeostasis
|
GO:0072503 |
128 |
0.533
|
Rat |
|
|
positive regulation of peptidyl tyrosine phosphorylation
|
GO:0050731 |
85 |
0.532
|
|
|
|
regulation of response to external stimulus
|
GO:0032101 |
222 |
0.523
|
|
|
|
negative regulation of transferase activity
|
GO:0051348 |
124 |
0.513
|
|
|
|
response to steroid hormone
|
GO:0048545 |
80 |
0.506
|
|
|
|
defense response
|
GO:0006952 |
315 |
0.502
|
|
|
|
positive regulation of proteasomal protein catabolic process
|
GO:1901800 |
35 |
0.500
|
|
|
|
menstrual cycle phase
|
GO:0022601 |
2 |
0.477
|
|
|
|
cellular metal ion homeostasis
|
GO:0006875 |
146 |
0.469
|
Rat |
|
|
cell activation
|
GO:0001775 |
213 |
0.467
|
|
|
|
response to organic cyclic compound
|
GO:0014070 |
204 |
0.462
|
|
|
|
regulation of humoral immune response mediated by circulating immunoglobulin
|
GO:0002923 |
3 |
0.442
|
|
|
|
ras protein signal transduction
|
GO:0007265 |
73 |
0.439
|
|
|
|
response to biotic stimulus
|
GO:0009607 |
276 |
0.434
|
|
|
|
negative regulation of epidermal growth factor activated receptor activity
|
GO:0007175 |
6 |
0.434
|
|
|
|
negative regulation of cellular amine metabolic process
|
GO:0033239 |
3 |
0.426
|
|
|
|
response to nitrogen compound
|
GO:1901698 |
184 |
0.421
|
|
|
|
cellular chemical homeostasis
|
GO:0055082 |
180 |
0.414
|
Rat |
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.404
|
|
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
140 |
0.401
|
|
|
|
gamma delta t cell activation
|
GO:0046629 |
3 |
0.401
|
|
|
|
positive regulation of cellular protein catabolic process
|
GO:1903364 |
37 |
0.399
|
|
|
|
regulation of b cell differentiation
|
GO:0045577 |
2 |
0.399
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.397
|
|
|
|
interleukin 2 mediated signaling pathway
|
GO:0038110 |
3 |
0.393
|
|
|
|
growth hormone receptor signaling pathway
|
GO:0060396 |
10 |
0.393
|
|
|
|
g protein coupled receptor signaling pathway
|
GO:0007186 |
207 |
0.390
|
|
|
|
endochondral ossification
|
GO:0001958 |
1 |
0.382
|
|
|
|
negative regulation of homeostatic process
|
GO:0032845 |
59 |
0.381
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
7 |
0.379
|
|
|
|
cellular response to endogenous stimulus
|
GO:0071495 |
336 |
0.376
|
|
|
|
divalent metal ion transport
|
GO:0070838 |
152 |
0.373
|
|
|
|
small gtpase mediated signal transduction
|
GO:0007264 |
78 |
0.360
|
|
|
|
proteasome mediated ubiquitin dependent protein catabolic process
|
GO:0043161 |
156 |
0.354
|
|
|
|
positive regulation of jak stat cascade
|
GO:0046427 |
35 |
0.351
|
|
|
|
response to peptide
|
GO:1901652 |
65 |
0.348
|
|
|
|
dna replication
|
GO:0006260 |
116 |
0.347
|
|
|
|
response to alcohol
|
GO:0097305 |
64 |
0.345
|
|
|
|
response to organonitrogen compound
|
GO:0010243 |
156 |
0.344
|
|
|
|
calcium ion transport
|
GO:0006816 |
147 |
0.335
|
|
|
|
jak stat cascade
|
GO:0007259 |
46 |
0.332
|
|
|
|
neuron projection regeneration
|
GO:0031102 |
1 |
0.328
|
|
|
|
regulation of peptidyl tyrosine phosphorylation
|
GO:0050730 |
108 |
0.328
|
|
|
|
negative regulation of protein modification process
|
GO:0031400 |
200 |
0.326
|
|
|
|
divalent inorganic cation homeostasis
|
GO:0072507 |
136 |
0.325
|
Rat |
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
313 |
0.321
|
|
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
267 |
0.317
|
|
|
|
regulation of neuron differentiation
|
GO:0045664 |
70 |
0.316
|
|
|
|
negative regulation of humoral immune response
|
GO:0002921 |
7 |
0.316
|
|
|
|
modification dependent macromolecule catabolic process
|
GO:0043632 |
212 |
0.316
|
|
|
|
positive regulation of cellular catabolic process
|
GO:0031331 |
284 |
0.314
|
|
|
|
negative regulation of response to wounding
|
GO:1903035 |
47 |
0.311
|
|
|
|
immune response
|
GO:0006955 |
307 |
0.310
|
|
|
|
cellular homeostasis
|
GO:0019725 |
196 |
0.308
|
Rat |
|
|
metal ion homeostasis
|
GO:0055065 |
169 |
0.308
|
Rat |
|
|
rhythmic behavior
|
GO:0007622 |
2 |
0.307
|
|
|
|
multicellular organismal aging
|
GO:0010259 |
3 |
0.306
|
|
|
|
cytosolic calcium ion homeostasis
|
GO:0051480 |
89 |
0.305
|
Rat |
|
|
negative regulation of cell proliferation
|
GO:0008285 |
228 |
0.303
|
|
|
|
cellular response to hormone stimulus
|
GO:0032870 |
125 |
0.294
|
|
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
244 |
0.293
|
|
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.292
|
Rat |
|
|
regulation of tyrosine phosphorylation of stat protein
|
GO:0042509 |
30 |
0.292
|
|
|
|
negative regulation of cell differentiation
|
GO:0045596 |
171 |
0.290
|
|
|
|
negative regulation of leukocyte differentiation
|
GO:1902106 |
24 |
0.290
|
|
|
|
cytokine production
|
GO:0001816 |
247 |
0.289
|
|
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
380 |
0.289
|
|
|
|
regulation of proteasomal ubiquitin dependent protein catabolic process
|
GO:0032434 |
71 |
0.279
|
|
|
|
negative regulation of programmed cell death
|
GO:0043069 |
321 |
0.278
|
Rat |
|
|
ubiquitin dependent protein catabolic process
|
GO:0006511 |
206 |
0.276
|
|
|
|
regulation of proteolysis involved in cellular protein catabolic process
|
GO:1903050 |
91 |
0.272
|
|
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.270
|
|
|
|
positive regulation of gamma delta t cell activation
|
GO:0046645 |
1 |
0.269
|
|
|
|
response to bacterium
|
GO:0009617 |
144 |
0.269
|
|
|
|
positive regulation of proteolysis involved in cellular protein catabolic process
|
GO:1903052 |
35 |
0.266
|
|
|
|
negative regulation of transport
|
GO:0051051 |
176 |
0.266
|
|
|
|
locomotory behavior
|
GO:0007626 |
1 |
0.264
|
|
|
|
positive regulation of tyrosine phosphorylation of stat protein
|
GO:0042531 |
28 |
0.263
|
|
|
|
myeloid cell differentiation
|
GO:0030099 |
117 |
0.262
|
|
|
|
positive regulation of transport
|
GO:0051050 |
336 |
0.261
|
|
|
|
cellular response to peptide
|
GO:1901653 |
59 |
0.260
|
|
|
|
positive regulation of cytokine production
|
GO:0001819 |
167 |
0.260
|
|
|
|
hemopoiesis
|
GO:0030097 |
180 |
0.260
|
Zebrafish |
|
|
positive regulation of catabolic process
|
GO:0009896 |
310 |
0.255
|
|
|
|
response to peptide hormone
|
GO:0043434 |
61 |
0.247
|
|
|
|
regulation of response to wounding
|
GO:1903034 |
101 |
0.243
|
|
|
|
response to cytokine
|
GO:0034097 |
232 |
0.242
|
|
|
|
long term memory
|
GO:0007616 |
2 |
0.242
|
|
|
|
negative regulation of cytokine production
|
GO:0001818 |
82 |
0.241
|
|
|
|
cellular response to cytokine stimulus
|
GO:0071345 |
181 |
0.240
|
|
|
|
positive regulation of dna replication
|
GO:0045740 |
35 |
0.240
|
|
|
|
secretion
|
GO:0046903 |
254 |
0.239
|
|
|
|
nervous system development
|
GO:0007399 |
293 |
0.238
|
Mouse |
|
|
epithelial cell differentiation
|
GO:0030855 |
141 |
0.238
|
|
|
|
regulation of lymphocyte proliferation
|
GO:0050670 |
64 |
0.236
|
|
|
|
circadian behavior
|
GO:0048512 |
2 |
0.231
|
|
|
|
monocarboxylic acid metabolic process
|
GO:0032787 |
185 |
0.225
|
|
|
|
tyrosine phosphorylation of stat5 protein
|
GO:0042506 |
13 |
0.225
|
|
|
|
regulation of leukocyte activation
|
GO:0002694 |
115 |
0.224
|
|
|
|
negative regulation of humoral immune response mediated by circulating immunoglobulin
|
GO:0002924 |
3 |
0.223
|
|
|
|
determination of adult lifespan
|
GO:0008340 |
2 |
0.222
|
|
|
|
memory
|
GO:0007613 |
3 |
0.222
|
|
|
|
phagocytosis recognition
|
GO:0006910 |
3 |
0.216
|
|
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.215
|
|
|
|
regulation of cellular carbohydrate metabolic process
|
GO:0010675 |
47 |
0.215
|
|
|
|
positive regulation of b cell differentiation
|
GO:0045579 |
1 |
0.211
|
|
|
|
positive regulation of protein catabolic process
|
GO:0045732 |
75 |
0.210
|
|
|
|
regulation of cell activation
|
GO:0050865 |
125 |
0.210
|
|
|
|
regulation of myeloid leukocyte differentiation
|
GO:0002761 |
39 |
0.209
|
|
|
|
stem cell division
|
GO:0017145 |
2 |
0.209
|
|
|
|
positive regulation of cell death
|
GO:0010942 |
263 |
0.206
|
|
|
|
endochondral bone morphogenesis
|
GO:0060350 |
3 |
0.205
|
|
|
|
regulation of cell development
|
GO:0060284 |
161 |
0.202
|
|
|
|
axon regeneration
|
GO:0031103 |
1 |
0.197
|
|
|
|
regulation of protein tyrosine kinase activity
|
GO:0061097 |
36 |
0.196
|
|
|
|
proteasomal protein catabolic process
|
GO:0010498 |
176 |
0.196
|
|
|
|
regulation of mononuclear cell proliferation
|
GO:0032944 |
65 |
0.194
|
|
|
|
metal ion transport
|
GO:0030001 |
272 |
0.193
|
|
|
|
regulation of homeostatic process
|
GO:0032844 |
121 |
0.191
|
|
|
|
organ morphogenesis
|
GO:0009887 |
147 |
0.191
|
|
|
|
negative regulation of phosphorylation
|
GO:0042326 |
174 |
0.189
|
|
|
|
regulation of cellular response to stress
|
GO:0080135 |
244 |
0.189
|
|
|
|
negative regulation of monocyte differentiation
|
GO:0045656 |
3 |
0.189
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
289 |
0.188
|
|
|
|
tumor necrosis factor superfamily cytokine production
|
GO:0071706 |
45 |
0.187
|
|
|
|
hair cell differentiation
|
GO:0035315 |
2 |
0.184
|
|
|
|
cell development
|
GO:0048468 |
328 |
0.184
|
|
|
|
positive regulation of lymphocyte differentiation
|
GO:0045621 |
13 |
0.179
|
|
|
|
cytokine secretion
|
GO:0050663 |
64 |
0.177
|
|
|
|
regulation of cell projection organization
|
GO:0031344 |
107 |
0.177
|
|
|
|
positive regulation of proteolysis
|
GO:0045862 |
142 |
0.172
|
|
|
|
peripheral nervous system development
|
GO:0007422 |
2 |
0.171
|
|
|
|
actin cytoskeleton organization
|
GO:0030036 |
207 |
0.170
|
|
|
|
regulation of epidermal growth factor activated receptor activity
|
GO:0007176 |
14 |
0.170
|
|
|
|
sex determination
|
GO:0007530 |
3 |
0.170
|
|
|
|
modification dependent protein catabolic process
|
GO:0019941 |
209 |
0.167
|
|
|
|
positive regulation of lymphocyte activation
|
GO:0051251 |
73 |
0.167
|
|
|
|
negative regulation of receptor activity
|
GO:2000272 |
15 |
0.165
|
|
|
|
regulation of immune response
|
GO:0050776 |
201 |
0.162
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
183 |
0.157
|
|
|
|
regulation of myeloid leukocyte mediated immunity
|
GO:0002886 |
4 |
0.156
|
|
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.155
|
Rat |
|
|
cellular response to abiotic stimulus
|
GO:0071214 |
117 |
0.155
|
|
|
|
negative regulation of immune system process
|
GO:0002683 |
136 |
0.152
|
|
|
|
regulation of reactive oxygen species biosynthetic process
|
GO:1903426 |
3 |
0.152
|
|
|
|
regulation of cell differentiation
|
GO:0045595 |
393 |
0.151
|
|
|
|
ion homeostasis
|
GO:0050801 |
230 |
0.151
|
Rat |
|
|
regulation of ion transmembrane transport
|
GO:0034765 |
132 |
0.150
|
|
|
|
regulation of map kinase activity
|
GO:0043405 |
108 |
0.148
|
|
|
|
response to abiotic stimulus
|
GO:0009628 |
336 |
0.146
|
|
|
|
transmembrane transport
|
GO:0055085 |
399 |
0.144
|
|
|
|
activation of janus kinase activity
|
GO:0042976 |
7 |
0.143
|
|
|
|
reactive nitrogen species metabolic process
|
GO:2001057 |
3 |
0.142
|
|
|
|
immune effector process
|
GO:0002252 |
159 |
0.142
|
|
|
|
response to molecule of bacterial origin
|
GO:0002237 |
82 |
0.141
|
|
|
|
negative regulation of peptidyl tyrosine phosphorylation
|
GO:0050732 |
20 |
0.141
|
|
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
267 |
0.141
|
|
|
|
regulation of small gtpase mediated signal transduction
|
GO:0051056 |
156 |
0.140
|
|
|
|
negative regulation of myeloid cell apoptotic process
|
GO:0033033 |
4 |
0.139
|
|
|
|
regulation of myeloid cell differentiation
|
GO:0045637 |
81 |
0.138
|
|
|
|
protein catabolic process
|
GO:0030163 |
325 |
0.138
|
|
|
|
positive regulation of neuron differentiation
|
GO:0045666 |
40 |
0.137
|
|
|
|
regulation of neurogenesis
|
GO:0050767 |
82 |
0.136
|
|
|
|
response to other organism
|
GO:0051707 |
261 |
0.134
|
|
|
|
cytokine biosynthetic process
|
GO:0042089 |
37 |
0.133
|
|
|
|
cation homeostasis
|
GO:0055080 |
189 |
0.133
|
Rat |
|
|
regulation of neuron projection development
|
GO:0010975 |
57 |
0.133
|
|
|
|
regulation of calcium ion transport into cytosol
|
GO:0010522 |
33 |
0.133
|
|
|
|
divalent inorganic cation transport
|
GO:0072511 |
158 |
0.132
|
|
|
|
negative regulation of jak stat cascade
|
GO:0046426 |
4 |
0.131
|
|
|
|
positive regulation of reactive oxygen species biosynthetic process
|
GO:1903428 |
2 |
0.131
|
|
|
|
branched chain amino acid metabolic process
|
GO:0009081 |
4 |
0.130
|
|
|
|
leukocyte proliferation
|
GO:0070661 |
74 |
0.129
|
|
|
|
response to axon injury
|
GO:0048678 |
1 |
0.128
|
|
|
|
ion transmembrane transport
|
GO:0034220 |
338 |
0.125
|
|
|
|
regulation of ion transport
|
GO:0043269 |
189 |
0.124
|
|
|
|
negative regulation of b cell receptor signaling pathway
|
GO:0050859 |
2 |
0.123
|
|
|
|
negative regulation of leukocyte apoptotic process
|
GO:2000107 |
16 |
0.123
|
|
|
|
positive regulation of proteasomal ubiquitin dependent protein catabolic process
|
GO:0032436 |
30 |
0.121
|
|
|
|
positive regulation of leukocyte differentiation
|
GO:1902107 |
37 |
0.120
|
|
|
|
compound eye development
|
GO:0048749 |
1 |
0.119
|
|
|
|
positive regulation of tyrosine phosphorylation of stat5 protein
|
GO:0042523 |
11 |
0.119
|
|
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.118
|
|
|
|
regulation of proteolysis
|
GO:0030162 |
293 |
0.117
|
|
|
|
negative regulation of alpha beta t cell activation
|
GO:0046636 |
3 |
0.116
|
|
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.116
|
|
|
|
negative regulation of cell activation
|
GO:0050866 |
33 |
0.115
|
|
|
|
response to lipopolysaccharide
|
GO:0032496 |
70 |
0.114
|
|
|
|
cardiac muscle cell apoptotic process
|
GO:0010659 |
3 |
0.111
|
|
|
|
regulation of calcium ion transport
|
GO:0051924 |
79 |
0.110
|
|
|
|
mapk cascade
|
GO:0000165 |
288 |
0.108
|
|
|
|
regulation of protein catabolic process
|
GO:0042176 |
155 |
0.108
|
|
|
|
regulation of dna metabolic process
|
GO:0051052 |
153 |
0.107
|
|
|
|
cellular response to lipid
|
GO:0071396 |
127 |
0.107
|
|
|
|
regulation of defense response
|
GO:0031347 |
154 |
0.107
|
|
|
|
negative regulation of mapk cascade
|
GO:0043409 |
56 |
0.105
|
|
|
|
single organismal cell cell adhesion
|
GO:0016337 |
148 |
0.105
|
|
|
|
lactation
|
GO:0007595 |
3 |
0.105
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
179 |
0.104
|
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
249 |
0.104
|
|
|
|
regulation of immune effector process
|
GO:0002697 |
91 |
0.104
|
|
|
|
negative regulation of serotonin secretion
|
GO:0014063 |
1 |
0.102
|
|
|
|
regulation of cell cycle
|
GO:0051726 |
393 |
0.101
|
|
|
|
regulation of interleukin 6 mediated signaling pathway
|
GO:0070103 |
3 |
0.098
|
|
|
|
actin filament based process
|
GO:0030029 |
224 |
0.098
|
|
|
|
cellular response to insulin stimulus
|
GO:0032869 |
41 |
0.097
|
|
|
|
cellular response to molecule of bacterial origin
|
GO:0071219 |
62 |
0.097
|
|
|
|
activation of mapk activity
|
GO:0000187 |
45 |
0.097
|
|
|
|
organic hydroxy compound transport
|
GO:0015850 |
63 |
0.097
|
|
|
|
replacement ossification
|
GO:0036075 |
1 |
0.096
|
|
|
|
serotonin transport
|
GO:0006837 |
3 |
0.096
|
|
|
|
negative regulation of ion transport
|
GO:0043271 |
39 |
0.095
|
|
|
|
cellular protein catabolic process
|
GO:0044257 |
261 |
0.095
|
|
|
|
negative regulation of cell development
|
GO:0010721 |
48 |
0.095
|
|
|
|
taurine metabolic process
|
GO:0019530 |
1 |
0.094
|
|
|
|
response to inorganic substance
|
GO:0010035 |
127 |
0.094
|
|
|
|
regulation of cytokine biosynthetic process
|
GO:0042035 |
35 |
0.093
|
|
|
|
regulation of nervous system development
|
GO:0051960 |
88 |
0.092
|
|
|
|
aging
|
GO:0007568 |
66 |
0.092
|
|
|
|
regulation of receptor activity
|
GO:0010469 |
47 |
0.091
|
|
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
190 |
0.090
|
|
|
|
hematopoietic or lymphoid organ development
|
GO:0048534 |
186 |
0.089
|
Zebrafish |
|
|
negative regulation of kinase activity
|
GO:0033673 |
106 |
0.088
|
|
|
|
regulation of transmembrane transporter activity
|
GO:0022898 |
74 |
0.088
|
|
|
|
regulation of cellular protein catabolic process
|
GO:1903362 |
96 |
0.088
|
|
|
|
ribonucleotide catabolic process
|
GO:0009261 |
405 |
0.088
|
|
|
|
negative regulation of ion transmembrane transport
|
GO:0034766 |
26 |
0.088
|
|
|
|
negative regulation of protein kinase activity
|
GO:0006469 |
98 |
0.087
|
|
|
|
regulation of response to osmotic stress
|
GO:0047484 |
3 |
0.087
|
|
|
|
blastoderm segmentation
|
GO:0007350 |
2 |
0.087
|
|
|
|
histone modification
|
GO:0016570 |
251 |
0.087
|
|
|
|
regulation of tyrosine phosphorylation of stat3 protein
|
GO:0042516 |
18 |
0.087
|
|
|
|
tumor necrosis factor production
|
GO:0032640 |
43 |
0.086
|
|
|
|
tricarboxylic acid metabolic process
|
GO:0072350 |
4 |
0.086
|
|
|
|
lymphocyte proliferation
|
GO:0046651 |
70 |
0.086
|
|
|
|
reactive oxygen species biosynthetic process
|
GO:1903409 |
4 |
0.086
|
|
|
|
post embryonic development
|
GO:0009791 |
2 |
0.085
|
|
|
|
regulation of tor signaling
|
GO:0032006 |
30 |
0.084
|
|
|
|
blood vessel development
|
GO:0001568 |
172 |
0.084
|
|
|
|
cellular ion homeostasis
|
GO:0006873 |
168 |
0.083
|
Rat |
|
|
positive regulation of reactive oxygen species metabolic process
|
GO:2000379 |
24 |
0.082
|
|
|
|
regulation of reactive oxygen species metabolic process
|
GO:2000377 |
41 |
0.082
|
|
|
|
negative regulation of cellular component organization
|
GO:0051129 |
235 |
0.079
|
|
|
|
defense response to virus
|
GO:0051607 |
71 |
0.079
|
|
|
|
regulation of innate immune response
|
GO:0045088 |
97 |
0.079
|
|
|
|
negative regulation of leukocyte activation
|
GO:0002695 |
26 |
0.079
|
|
|
|
negative regulation of calcium ion transport
|
GO:0051926 |
19 |
0.078
|
|
|
|
negative regulation of tumor necrosis factor biosynthetic process
|
GO:0042536 |
3 |
0.077
|
|
|
|
striated muscle cell apoptotic process
|
GO:0010658 |
3 |
0.077
|
|
|
|
cell killing
|
GO:0001906 |
34 |
0.077
|
|
|
|
anion transport
|
GO:0006820 |
161 |
0.076
|
|
|
|
regulation of growth
|
GO:0040008 |
165 |
0.076
|
|
|
|
regulation of striated muscle cell apoptotic process
|
GO:0010662 |
3 |
0.074
|
|
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.074
|
|
|
|
positive regulation of map kinase activity
|
GO:0043406 |
80 |
0.072
|
|
|
|
insulin receptor signaling pathway
|
GO:0008286 |
23 |
0.072
|
|
|
|
negative regulation of production of molecular mediator of immune response
|
GO:0002701 |
13 |
0.072
|
|
|
|
negative regulation of dendritic cell apoptotic process
|
GO:2000669 |
3 |
0.072
|
|
|
|
regulation of hormone levels
|
GO:0010817 |
125 |
0.072
|
|
|
|
regulation of tyrosine phosphorylation of stat5 protein
|
GO:0042522 |
12 |
0.071
|
|
|
|
protein kinase c activating g protein coupled receptor signaling pathway
|
GO:0007205 |
2 |
0.070
|
|
|
|
response to external biotic stimulus
|
GO:0043207 |
261 |
0.070
|
|
|
|
fatty acid metabolic process
|
GO:0006631 |
115 |
0.070
|
|
|
|
positive regulation of immune system process
|
GO:0002684 |
283 |
0.069
|
|
|
|
regulation of intracellular transport
|
GO:0032386 |
195 |
0.069
|
|
|
|
negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002823 |
8 |
0.069
|
|
|
|
regulation of exocytosis
|
GO:0017157 |
46 |
0.069
|
|
|
|
positive regulation of cardiac muscle cell apoptotic process
|
GO:0010666 |
1 |
0.068
|
|
|
|
single organism membrane organization
|
GO:0044802 |
268 |
0.068
|
|
|
|
negative regulation of cellular amino acid metabolic process
|
GO:0045763 |
2 |
0.068
|
|
|
|
oogenesis
|
GO:0048477 |
2 |
0.068
|
|
|
|
regulation of dna replication
|
GO:0006275 |
68 |
0.067
|
|
|
|
response to virus
|
GO:0009615 |
126 |
0.067
|
|
|
|
regulation of neuron projection regeneration
|
GO:0070570 |
1 |
0.067
|
|
|
|
positive regulation of neurogenesis
|
GO:0050769 |
49 |
0.067
|
|
|
|
regulation of polysaccharide biosynthetic process
|
GO:0032885 |
20 |
0.066
|
|
|
|
tor signaling
|
GO:0031929 |
39 |
0.065
|
|
|
|
adaptive immune response
|
GO:0002250 |
49 |
0.064
|
|
|
|
negative regulation of interleukin 10 production
|
GO:0032693 |
7 |
0.064
|
|
|
|
vesicle mediated transport
|
GO:0016192 |
371 |
0.063
|
|
|
|
regulation of leukocyte mediated immunity
|
GO:0002703 |
38 |
0.062
|
|
|
|
leukocyte apoptotic process
|
GO:0071887 |
31 |
0.062
|
|
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
175 |
0.062
|
|
|
|
mononuclear cell proliferation
|
GO:0032943 |
71 |
0.062
|
|
|
|
growth
|
GO:0040007 |
202 |
0.062
|
|
|
|
asymmetric stem cell division
|
GO:0098722 |
1 |
0.062
|
|
|
|
cellular response to interleukin 12
|
GO:0071349 |
3 |
0.061
|
|
|
|
rho protein signal transduction
|
GO:0007266 |
26 |
0.061
|
|
|
|
segmentation
|
GO:0035282 |
4 |
0.061
|
|
|
|
cell migration involved in gastrulation
|
GO:0042074 |
1 |
0.060
|
|
|
|
regulation of metal ion transport
|
GO:0010959 |
120 |
0.060
|
|
|
|
jnk cascade
|
GO:0007254 |
80 |
0.060
|
|
|
|
regulation of anatomical structure morphogenesis
|
GO:0022603 |
286 |
0.060
|
|
|
|
somatic stem cell division
|
GO:0048103 |
1 |
0.060
|
|
|
|
carbohydrate transport
|
GO:0008643 |
37 |
0.059
|
|
|
|
defense response to other organism
|
GO:0098542 |
129 |
0.059
|
|
|
|
regulation of cytoplasmic transport
|
GO:1903649 |
149 |
0.059
|
|
|
|
negative regulation of myeloid leukocyte differentiation
|
GO:0002762 |
16 |
0.058
|
|
|
|
positive regulation of dna metabolic process
|
GO:0051054 |
73 |
0.058
|
|
|
|
regulation of leukocyte proliferation
|
GO:0070663 |
67 |
0.058
|
|
|
|
b cell activation
|
GO:0042113 |
33 |
0.057
|
|
|
|
monoamine transport
|
GO:0015844 |
10 |
0.057
|
|
|
|
protein processing
|
GO:0016485 |
226 |
0.057
|
|
|
|
apoptotic signaling pathway
|
GO:0097190 |
268 |
0.057
|
|
|
|
epidermis development
|
GO:0008544 |
59 |
0.056
|
|
|
|
regeneration
|
GO:0031099 |
4 |
0.056
|
|
|
|
neurogenesis
|
GO:0022008 |
169 |
0.056
|
|
|
|
regulation of ion transmembrane transporter activity
|
GO:0032412 |
72 |
0.056
|
|
|
|
regulation of tyrosine phosphorylation of stat1 protein
|
GO:0042510 |
11 |
0.055
|
|
|
|
regulation of erythrocyte differentiation
|
GO:0045646 |
17 |
0.054
|
|
|
|
organonitrogen compound biosynthetic process
|
GO:1901566 |
200 |
0.054
|
|
|
|
cytosolic calcium ion transport
|
GO:0060401 |
48 |
0.054
|
|
|
|
positive regulation of response to external stimulus
|
GO:0032103 |
88 |
0.054
|
|
|
|
lymphocyte differentiation
|
GO:0030098 |
35 |
0.054
|
|
|
|
regulation of lymphocyte differentiation
|
GO:0045619 |
22 |
0.053
|
|
|
|
neuron differentiation
|
GO:0030182 |
138 |
0.053
|
|
|
|
interleukin 12 mediated signaling pathway
|
GO:0035722 |
3 |
0.053
|
|
|
|
regulation of cardiac muscle cell apoptotic process
|
GO:0010665 |
3 |
0.053
|
|
|
|
regulation of ras protein signal transduction
|
GO:0046578 |
155 |
0.052
|
|
|
|
sulfur compound metabolic process
|
GO:0006790 |
101 |
0.052
|
|
|
|
b cell differentiation
|
GO:0030183 |
6 |
0.052
|
|
|
|
response to tumor necrosis factor
|
GO:0034612 |
76 |
0.052
|
|
|
|
regulation of ion homeostasis
|
GO:2000021 |
73 |
0.051
|
|
|
|
protein autophosphorylation
|
GO:0046777 |
123 |
0.051
|
|
|
|
regulation of leukocyte apoptotic process
|
GO:2000106 |
25 |
0.051
|
|
|
|
response to food
|
GO:0032094 |
1 |
0.051
|
|
|
|
covalent chromatin modification
|
GO:0016569 |
254 |
0.051
|
|
|
|
regulation of establishment of protein localization
|
GO:0070201 |
242 |
0.051
|
|
|
|
positive regulation of cell proliferation
|
GO:0008284 |
301 |
0.050
|
|
|
|
single organism cell adhesion
|
GO:0098602 |
179 |
0.050
|
|
|
|
regulation of endocytosis
|
GO:0030100 |
72 |
0.050
|
|
|
|
leukocyte differentiation
|
GO:0002521 |
98 |
0.050
|
|
|
|
regulation of erk1 and erk2 cascade
|
GO:0070372 |
99 |
0.049
|
|
|
|
negative regulation of cytokine biosynthetic process
|
GO:0042036 |
11 |
0.049
|
|
|
|
positive regulation of erythrocyte differentiation
|
GO:0045648 |
11 |
0.049
|
|
|
|
actin filament based movement
|
GO:0030048 |
17 |
0.049
|
|
|
|
positive regulation of natural killer cell activation
|
GO:0032816 |
8 |
0.048
|
|
|
|
positive regulation of homeostatic process
|
GO:0032846 |
47 |
0.048
|
|
|
|
negative regulation of phagocytosis
|
GO:0050765 |
4 |
0.048
|
|
|
|
oxidation reduction process
|
GO:0055114 |
396 |
0.047
|
|
|
|
positive regulation of cell development
|
GO:0010720 |
92 |
0.047
|
|
|
|
stress activated protein kinase signaling cascade
|
GO:0031098 |
94 |
0.047
|
|
|
|
negative regulation of response to external stimulus
|
GO:0032102 |
83 |
0.047
|
|
|
|
phosphatidylinositol mediated signaling
|
GO:0048015 |
55 |
0.047
|
|
|
|
symbiosis encompassing mutualism through parasitism
|
GO:0044403 |
156 |
0.047
|
|
|
|
positive regulation of muscle cell apoptotic process
|
GO:0010661 |
4 |
0.047
|
|
|
|
associative learning
|
GO:0008306 |
1 |
0.047
|
|
|
|
regulation of natural killer cell differentiation
|
GO:0032823 |
2 |
0.046
|
|
|
|
female gamete generation
|
GO:0007292 |
2 |
0.046
|
|
|
|
regulation of cation channel activity
|
GO:2001257 |
33 |
0.046
|
|
|
|
positive regulation of tumor necrosis factor superfamily cytokine production
|
GO:1903557 |
22 |
0.046
|
|
|
|
positive regulation of defense response
|
GO:0031349 |
87 |
0.046
|
|
|
|
interleukin 4 mediated signaling pathway
|
GO:0035771 |
3 |
0.046
|
|
|
|
negative regulation of tyrosine phosphorylation of stat3 protein
|
GO:0042518 |
2 |
0.045
|
|
|
|
lipid metabolic process
|
GO:0006629 |
381 |
0.045
|
|
|
|
positive regulation of cell activation
|
GO:0050867 |
81 |
0.045
|
|
|
|
peptide secretion
|
GO:0002790 |
51 |
0.045
|
|
|
|
nuclear import
|
GO:0051170 |
106 |
0.045
|
|
|
|
leukocyte activation
|
GO:0045321 |
164 |
0.045
|
|
|
|
cytokine mediated signaling pathway
|
GO:0019221 |
109 |
0.044
|
|
|
|
calcium ion homeostasis
|
GO:0055074 |
122 |
0.044
|
Rat |
|
|
cellular response to lipopolysaccharide
|
GO:0071222 |
57 |
0.044
|
|
|
|
regulation of tumor necrosis factor biosynthetic process
|
GO:0042534 |
8 |
0.044
|
|
|
|
negative regulation of adaptive immune response
|
GO:0002820 |
9 |
0.044
|
|
|
|
interleukin 6 production
|
GO:0032635 |
37 |
0.044
|
|
|
|
cell division
|
GO:0051301 |
168 |
0.044
|
|
|
|
negative regulation of cell projection organization
|
GO:0031345 |
22 |
0.044
|
|
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
127 |
0.044
|
|
|
|
transformation of host cell by virus
|
GO:0019087 |
2 |
0.043
|
|
|
|
regulation of mapk cascade
|
GO:0043408 |
262 |
0.043
|
|
|
|
cellular lactam metabolic process
|
GO:0072338 |
1 |
0.042
|
|
|
|
response to extracellular stimulus
|
GO:0009991 |
85 |
0.042
|
|
|
|
multi organism cellular process
|
GO:0044764 |
156 |
0.042
|
|
|
|
regulation of secretion by cell
|
GO:1903530 |
177 |
0.042
|
|
|
|
modulation by virus of host morphology or physiology
|
GO:0019048 |
10 |
0.042
|
|
|
|
dephosphorylation
|
GO:0016311 |
209 |
0.042
|
|
|
|
regulation of cellular component biogenesis
|
GO:0044087 |
281 |
0.042
|
|
|
|
nucleotide catabolic process
|
GO:0009166 |
408 |
0.042
|
|
|
|
regulation of erbb signaling pathway
|
GO:1901184 |
27 |
0.041
|
|
|
|
nitrogen compound transport
|
GO:0071705 |
191 |
0.041
|
|
|
|
response to hypoxia
|
GO:0001666 |
96 |
0.041
|
|
|
|
epithelium development
|
GO:0060429 |
227 |
0.041
|
|
|
|
cellular polysaccharide biosynthetic process
|
GO:0033692 |
21 |
0.041
|
|
|
|
purine ribonucleotide biosynthetic process
|
GO:0009152 |
79 |
0.041
|
|
|
|
single organism carbohydrate metabolic process
|
GO:0044723 |
193 |
0.041
|
|
|
|
prostate gland development
|
GO:0030850 |
3 |
0.041
|
|
|
|
negative regulation of transmembrane transport
|
GO:0034763 |
29 |
0.041
|
|
|
|
maintenance of location
|
GO:0051235 |
112 |
0.041
|
|
|
|
generation of neurons
|
GO:0048699 |
152 |
0.040
|
|
|
|
regulation of interferon beta secretion
|
GO:0035547 |
1 |
0.040
|
|
|
|
regulation of inflammatory response
|
GO:0050727 |
46 |
0.040
|
|
|
|
erk1 and erk2 cascade
|
GO:0070371 |
104 |
0.040
|
|
|
|
negative regulation of transporter activity
|
GO:0032410 |
25 |
0.040
|
|
|
|
cellular response to organic cyclic compound
|
GO:0071407 |
127 |
0.039
|
|
|
|
interspecies interaction between organisms
|
GO:0044419 |
156 |
0.039
|
|
|
|
circulatory system development
|
GO:0072359 |
262 |
0.039
|
Mouse |
|
|
lymphocyte mediated immunity
|
GO:0002449 |
48 |
0.039
|
|
|
|
regulation of protein secretion
|
GO:0050708 |
86 |
0.039
|
|
|
|
cellular response to biotic stimulus
|
GO:0071216 |
71 |
0.039
|
|
|
|
positive regulation of cell adhesion
|
GO:0045785 |
84 |
0.039
|
|
|
|
signal transduction by phosphorylation
|
GO:0023014 |
297 |
0.038
|
|
|
|
negative regulation of inflammatory response
|
GO:0050728 |
22 |
0.038
|
|
|
|
negative regulation of epidermal growth factor receptor signaling pathway
|
GO:0042059 |
11 |
0.038
|
|
|
|
negative regulation of calcium ion transport into cytosol
|
GO:0010523 |
3 |
0.038
|
|
|
|
body fluid secretion
|
GO:0007589 |
9 |
0.038
|
|
|
|
negative regulation of cd4 positive alpha beta t cell activation
|
GO:2000515 |
1 |
0.037
|
|
|
|
regulation of cell cycle process
|
GO:0010564 |
266 |
0.037
|
|
|
|
interleukin 12 secretion
|
GO:0072610 |
1 |
0.037
|
|
|
|
inflammatory response
|
GO:0006954 |
79 |
0.037
|
|
|
|
regulation of purine nucleotide metabolic process
|
GO:1900542 |
264 |
0.037
|
|
|
|
regulation of multi organism process
|
GO:0043900 |
157 |
0.037
|
|
|
|
positive regulation of organelle organization
|
GO:0010638 |
195 |
0.037
|
|
|
|
response to decreased oxygen levels
|
GO:0036293 |
96 |
0.036
|
|
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
331 |
0.036
|
|
|
|
nerve development
|
GO:0021675 |
4 |
0.036
|
|
|
|
leukocyte migration
|
GO:0050900 |
107 |
0.036
|
|
|
|
positive regulation of t helper cell differentiation
|
GO:0045624 |
2 |
0.036
|
|
|
|
oxaloacetate metabolic process
|
GO:0006107 |
1 |
0.036
|
|
|
|
negative regulation of secretion by cell
|
GO:1903531 |
52 |
0.036
|
|
|
|
erbb signaling pathway
|
GO:0038127 |
44 |
0.036
|
|
|
|
positive regulation of cell motility
|
GO:2000147 |
177 |
0.036
|
|
|
|
cellular amide metabolic process
|
GO:0043603 |
69 |
0.036
|
|
|
|
purine nucleotide catabolic process
|
GO:0006195 |
405 |
0.035
|
|
|
|
glycoprotein metabolic process
|
GO:0009100 |
110 |
0.035
|
|
|
|
regulation of regulatory t cell differentiation
|
GO:0045589 |
4 |
0.035
|
|
|
|
positive regulation of myeloid cell differentiation
|
GO:0045639 |
39 |
0.035
|
|
|
|
negative regulation of osteoclast differentiation
|
GO:0045671 |
8 |
0.035
|
|
|
|
alpha amino acid metabolic process
|
GO:1901605 |
72 |
0.035
|
|
|
|
sensory organ development
|
GO:0007423 |
52 |
0.035
|
|
|
|
nucleoside phosphate catabolic process
|
GO:1901292 |
412 |
0.034
|
|
|
|
regulation of body fluid levels
|
GO:0050878 |
99 |
0.034
|
|
|
|
regulation of postsynaptic membrane potential
|
GO:0060078 |
1 |
0.034
|
|
|
|
negative regulation of neuron differentiation
|
GO:0045665 |
21 |
0.034
|
|
|
|
leukocyte mediated immunity
|
GO:0002443 |
59 |
0.034
|
|
|
|
response to interleukin 15
|
GO:0070672 |
6 |
0.034
|
|
|
|
endothelial cell migration
|
GO:0043542 |
86 |
0.034
|
|
|
|
cell substrate adhesion
|
GO:0031589 |
132 |
0.034
|
|
|
|
regulation of tumor necrosis factor production
|
GO:0032680 |
43 |
0.034
|
|
|
|
activation of jak2 kinase activity
|
GO:0042977 |
5 |
0.034
|
|
|
|
natural killer cell differentiation
|
GO:0001779 |
2 |
0.034
|
|
|
|
glycosyl compound catabolic process
|
GO:1901658 |
413 |
0.034
|
|
|
|
response to wounding
|
GO:0009611 |
168 |
0.033
|
|
|
|
neuroblast proliferation
|
GO:0007405 |
4 |
0.033
|
|
|
|
cell morphogenesis
|
GO:0000902 |
296 |
0.033
|
|
|
|
regulation of secretion
|
GO:0051046 |
194 |
0.033
|
|
|
|
nucleoside triphosphate metabolic process
|
GO:0009141 |
422 |
0.033
|
|
