Homo sapiens

203 known processes

ERCC6

excision repair cross-complementing rodent repair deficiency, complementation group 6

(Aliases: RAD26,ARMD5,COFS,CKN2,CSB,COFS1)

ERCC6 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
nucleotide excision repair GO:0006289 31 0.968
transcription coupled nucleotide excision repair GO:0006283 8 0.957
dna repair GO:0006281 198 0.942
cellular response to dna damage stimulus GO:0006974 379 0.908
response to light stimulus GO:0009416 87 0.616
cellular macromolecule catabolic process GO:0044265 380 0.589
response to abiotic stimulus GO:0009628 336 0.537
response to radiation GO:0009314 151 0.519
positive regulation of response to dna damage stimulus GO:2001022 43 0.447
protein autoubiquitination GO:0051865 37 0.438
regulation of dna repair GO:0006282 47 0.430
modification dependent macromolecule catabolic process GO:0043632 212 0.423
modification dependent protein catabolic process GO:0019941 209 0.380
protein ubiquitination GO:0016567 314 0.376
protein polyubiquitination GO:0000209 110 0.349
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.320
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.319
cellular protein catabolic process GO:0044257 261 0.279
ubiquitin dependent protein catabolic process GO:0006511 206 0.275
protein modification by small protein conjugation GO:0032446 342 0.266
positive regulation of dna metabolic process GO:0051054 73 0.250
protein catabolic process GO:0030163 325 0.233
response to ionizing radiation GO:0010212 65 0.205
proteasomal protein catabolic process GO:0010498 176 0.171
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.166
positive regulation of dna repair GO:0045739 25 0.149
dna damage checkpoint GO:0000077 68 0.117
chromatin organization GO:0006325 351 0.104
cell cycle checkpoint GO:0000075 117 0.098
post embryonic development GO:0009791 2 0.093
rna processing GO:0006396 255 0.091
response to oxidative stress GO:0006979 121 0.084
regulation of cell cycle GO:0051726 393 0.084
response to uv GO:0009411 73 0.080
regulation of cellular response to stress GO:0080135 244 0.078
regulation of cell cycle phase transition GO:1901987 126 0.074
regulation of response to dna damage stimulus GO:2001020 94 0.072
cellular response to abiotic stimulus GO:0071214 117 0.071
interspecies interaction between organisms GO:0044419 156 0.070
vesicle mediated transport GO:0016192 371 0.068
postreplication repair GO:0006301 12 0.063
purine nucleotide catabolic process GO:0006195 405 0.059
digestive system development GO:0055123 75 0.057
steroid metabolic process GO:0008202 94 0.057
purine nucleoside catabolic process GO:0006152 398 0.056
regulation of proteolysis GO:0030162 293 0.054
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.054
microtubule cytoskeleton organization GO:0000226 176 0.053
mitotic cell cycle phase transition GO:0044772 162 0.053
regulation of cellular ketone metabolic process GO:0010565 50 0.053
chromatin assembly or disassembly GO:0006333 78 0.052
mitotic cell cycle checkpoint GO:0007093 68 0.051
cell cycle phase transition GO:0044770 173 0.050
regulation of mitotic cell cycle GO:0007346 189 0.049
nucleoside triphosphate catabolic process GO:0009143 394 0.046
nuclear transport GO:0051169 179 0.046
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.045
cofactor metabolic process GO:0051186 87 0.045
response to transforming growth factor beta GO:0071559 94 0.044
mitotic cell cycle GO:0000278 326 0.044
negative regulation of cell cycle GO:0045786 193 0.044
viral process GO:0016032 146 0.044
intracellular protein transport GO:0006886 270 0.043
regulation of cell cycle process GO:0010564 266 0.043
defense response GO:0006952 315 0.042
nucleoside catabolic process GO:0009164 408 0.042
cellular ketone metabolic process GO:0042180 80 0.042
mitotic cell cycle process GO:1903047 286 0.042
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.042
amine metabolic process GO:0009308 44 0.042
regulation of mitotic cell cycle phase transition GO:1901990 118 0.041
cellular response to endogenous stimulus GO:0071495 336 0.041
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.041
regulation of proteasomal protein catabolic process GO:0061136 87 0.040
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.040
determination of adult lifespan GO:0008340 2 0.039
macromolecule methylation GO:0043414 97 0.039
cellular response to uv GO:0034644 32 0.039
negative regulation of cellular component organization GO:0051129 235 0.037
cellular component disassembly GO:0022411 92 0.037
purine ribonucleotide catabolic process GO:0009154 404 0.037
dna integrity checkpoint GO:0031570 71 0.036
covalent chromatin modification GO:0016569 254 0.035
cellular response to radiation GO:0071478 65 0.035
cellular response to growth factor stimulus GO:0071363 197 0.035
regulation of protein catabolic process GO:0042176 155 0.034
protein alkylation GO:0008213 74 0.034
histone modification GO:0016570 251 0.033
mrna processing GO:0006397 133 0.033
enzyme linked receptor protein signaling pathway GO:0007167 303 0.033
multicellular organismal aging GO:0010259 3 0.033
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.033
dna catabolic process GO:0006308 49 0.033
small molecule biosynthetic process GO:0044283 157 0.033
nucleoside triphosphate metabolic process GO:0009141 422 0.033
cellular amino acid metabolic process GO:0006520 116 0.032
regulation of intracellular transport GO:0032386 195 0.032
response to external biotic stimulus GO:0043207 261 0.032
protein k48 linked ubiquitination GO:0070936 38 0.032
response to drug GO:0042493 81 0.031
g2 dna damage checkpoint GO:0031572 26 0.031
regulation of multi organism process GO:0043900 157 0.030
nucleotide catabolic process GO:0009166 408 0.030
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.029
methylation GO:0032259 106 0.029
negative regulation of apoptotic process GO:0043066 316 0.029
ribonucleoside monophosphate metabolic process GO:0009161 187 0.029
isoprenoid metabolic process GO:0006720 39 0.028
lipid metabolic process GO:0006629 381 0.028
cellular amine metabolic process GO:0044106 41 0.028
positive regulation of catabolic process GO:0009896 310 0.028
negative regulation of programmed cell death GO:0043069 321 0.028
carboxylic acid biosynthetic process GO:0046394 97 0.028
positive regulation of proteolysis GO:0045862 142 0.028
negative regulation of cell cycle phase transition GO:1901988 89 0.027
fatty acid metabolic process GO:0006631 115 0.027
transforming growth factor beta receptor signaling pathway GO:0007179 76 0.027
regulation of defense response GO:0031347 154 0.027
endocytosis GO:0006897 159 0.026
regulation of protein localization GO:0032880 296 0.026
nitrogen compound transport GO:0071705 191 0.026
digestive tract development GO:0048565 75 0.026
organic acid biosynthetic process GO:0016053 97 0.026
lipid biosynthetic process GO:0008610 177 0.026
purine nucleoside triphosphate catabolic process GO:0009146 392 0.025
transmembrane transport GO:0055085 399 0.025
viral life cycle GO:0019058 132 0.025
regulation of cytoplasmic transport GO:1903649 149 0.025
cytoplasmic transport GO:0016482 379 0.025
dna recombination GO:0006310 77 0.024
generation of neurons GO:0048699 152 0.024
regulation of nucleocytoplasmic transport GO:0046822 98 0.024
steroid biosynthetic process GO:0006694 46 0.024
positive regulation of transport GO:0051050 336 0.024
coenzyme metabolic process GO:0006732 65 0.024
atp catabolic process GO:0006200 157 0.024
microtubule based process GO:0007017 210 0.024
mitotic nuclear division GO:0007067 119 0.023
cellular response to light stimulus GO:0071482 34 0.023
single organism cellular localization GO:1902580 332 0.023
mitotic dna damage checkpoint GO:0044773 28 0.023
positive regulation of cytoplasmic transport GO:1903651 82 0.023
chromatin modification GO:0016568 298 0.022
dna catabolic process endonucleolytic GO:0000737 37 0.022
cell division GO:0051301 168 0.022
immune response GO:0006955 307 0.022
locomotory behavior GO:0007626 1 0.022
innate immune response GO:0045087 178 0.022
nucleobase containing compound transport GO:0015931 51 0.022
response to other organism GO:0051707 261 0.022
dephosphorylation GO:0016311 209 0.022
regulation of cellular amine metabolic process GO:0033238 11 0.022
negative regulation of protein metabolic process GO:0051248 391 0.022
response to biotic stimulus GO:0009607 276 0.022
negative regulation of cell cycle process GO:0010948 121 0.021
regulation of cell growth GO:0001558 135 0.021
ribonucleoside triphosphate catabolic process GO:0009203 391 0.021
cellular macromolecular complex assembly GO:0034622 324 0.021
positive regulation of cellular catabolic process GO:0031331 284 0.021
multi organism cellular process GO:0044764 156 0.021
regulation of cytoskeleton organization GO:0051493 177 0.021
chemical homeostasis GO:0048878 306 0.021
cation transmembrane transport GO:0098655 238 0.021
cellular potassium ion transport GO:0071804 60 0.021
regulation of meiotic cell cycle GO:0051445 4 0.021
maintenance of location GO:0051235 112 0.021
protein k29 linked ubiquitination GO:0035519 4 0.020
regulation of protein transport GO:0051223 213 0.020
ras protein signal transduction GO:0007265 73 0.020
double strand break repair GO:0006302 101 0.020
negative regulation of alpha beta t cell activation GO:0046636 3 0.020
carbohydrate derivative biosynthetic process GO:1901137 207 0.020
regulation of cellular response to growth factor stimulus GO:0090287 76 0.020
purine ribonucleoside catabolic process GO:0046130 398 0.020
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 48 0.019
regulation of response to external stimulus GO:0032101 222 0.019
atp metabolic process GO:0046034 176 0.019
segmentation GO:0035282 4 0.019
neuromuscular junction development GO:0007528 3 0.019
regulation of cellular protein catabolic process GO:1903362 96 0.019
regulation of dna metabolic process GO:0051052 153 0.019
negative regulation of catalytic activity GO:0043086 335 0.019
negative regulation of cell death GO:0060548 345 0.019
regulation of phosphatidylinositol 3 kinase signaling GO:0014066 35 0.019
negative regulation of cellular protein metabolic process GO:0032269 353 0.019
nervous system development GO:0007399 293 0.019
ncrna processing GO:0034470 83 0.019
regulation of establishment of protein localization GO:0070201 242 0.019
purine ribonucleoside metabolic process GO:0046128 437 0.019
negative regulation of developmental process GO:0051093 247 0.018
nucleocytoplasmic transport GO:0006913 176 0.018
ribonucleoside catabolic process GO:0042454 406 0.018
negative regulation of defense response GO:0031348 47 0.018
phosphatidylinositol mediated signaling GO:0048015 55 0.018
sodium ion transmembrane transport GO:0035725 59 0.018
response to growth factor GO:0070848 205 0.018
cell projection organization GO:0030030 252 0.018
negative regulation of response to external stimulus GO:0032102 83 0.018
protein targeting GO:0006605 187 0.018
cellular lipid metabolic process GO:0044255 303 0.018
chromosome segregation GO:0007059 114 0.018
regulation of protein kinase activity GO:0045859 289 0.018
positive regulation of programmed cell death GO:0043068 249 0.018
neuron projection development GO:0031175 106 0.017
positive regulation of cellular component organization GO:0051130 376 0.017
rrna containing ribonucleoprotein complex export from nucleus GO:0071428 4 0.017
negative regulation of mitotic cell cycle GO:0045930 102 0.017
receptor mediated endocytosis GO:0006898 84 0.017
metal ion transport GO:0030001 272 0.017
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.017
potassium ion transmembrane transport GO:0071805 60 0.017
regulation of cofactor metabolic process GO:0051193 3 0.017
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.017
spermatid differentiation GO:0048515 4 0.017
spindle organization GO:0007051 53 0.017
ribonucleoprotein complex biogenesis GO:0022613 116 0.016
response to inorganic substance GO:0010035 127 0.016
negative regulation of multi organism process GO:0043901 92 0.016
organic hydroxy compound biosynthetic process GO:1901617 71 0.016
regulation of secretion GO:0051046 194 0.016
cell fate determination GO:0001709 3 0.016
inositol lipid mediated signaling GO:0048017 55 0.016
nuclear division GO:0000280 128 0.016
positive regulation of mapk cascade GO:0043410 190 0.016
ribonucleotide catabolic process GO:0009261 405 0.016
mapk cascade GO:0000165 288 0.016
ion homeostasis GO:0050801 230 0.016
defense response to other organism GO:0098542 129 0.016
apoptotic signaling pathway GO:0097190 268 0.015
monocarboxylic acid biosynthetic process GO:0072330 67 0.015
response to virus GO:0009615 126 0.015
regulation of actin filament based process GO:0032970 141 0.015
embryonic morphogenesis GO:0048598 85 0.015
monovalent inorganic cation transport GO:0015672 128 0.015
digestive tract morphogenesis GO:0048546 56 0.015
receptor internalization GO:0031623 43 0.015
ion transmembrane transport GO:0034220 338 0.015
regulation of transmembrane transport GO:0034762 139 0.015
oogenesis GO:0048477 2 0.015
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.015
regulation of actin cytoskeleton organization GO:0032956 116 0.015
tube development GO:0035295 125 0.015
establishment of protein localization to organelle GO:0072594 172 0.015
negative regulation of organelle organization GO:0010639 126 0.015
organophosphate catabolic process GO:0046434 430 0.015
epidermis development GO:0008544 59 0.015
negative regulation of phosphorylation GO:0042326 174 0.015
regulation of kinase activity GO:0043549 314 0.015
inorganic ion transmembrane transport GO:0098660 231 0.014
purine nucleoside triphosphate metabolic process GO:0009144 412 0.014
coenzyme biosynthetic process GO:0009108 24 0.014
hindbrain development GO:0030902 3 0.014
regulation of transmembrane transporter activity GO:0022898 74 0.014
immune effector process GO:0002252 159 0.014
regulation of mapk cascade GO:0043408 262 0.014
regulation of vesicle mediated transport GO:0060627 130 0.014
secretion by cell GO:0032940 226 0.014
protein localization to organelle GO:0033365 280 0.014
positive regulation of intracellular transport GO:0032388 104 0.014
negative regulation of immune system process GO:0002683 136 0.014
myeloid cell differentiation GO:0030099 117 0.014
positive regulation of immune response GO:0050778 159 0.014
cell growth GO:0016049 160 0.014
cofactor biosynthetic process GO:0051188 31 0.014
regulation of lipid metabolic process GO:0019216 96 0.014
organelle fission GO:0048285 149 0.014
regulation of transporter activity GO:0032409 82 0.014
dna conformation change GO:0071103 113 0.014
mitotic dna integrity checkpoint GO:0044774 30 0.014
regulation of cell differentiation GO:0045595 393 0.014
regulation of viral process GO:0050792 103 0.013
negative regulation of cell proliferation GO:0008285 228 0.013
organic hydroxy compound metabolic process GO:1901615 147 0.013
female gamete generation GO:0007292 2 0.013
regulation of transferase activity GO:0051338 355 0.013
immune system development GO:0002520 195 0.013
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 37 0.013
potassium ion transport GO:0006813 62 0.013
positive regulation of organelle organization GO:0010638 195 0.013
peptidyl tyrosine phosphorylation GO:0018108 170 0.013
small gtpase mediated signal transduction GO:0007264 78 0.013
negative regulation of transport GO:0051051 176 0.013
regulation of apoptotic signaling pathway GO:2001233 175 0.013
regulation of cellular component movement GO:0051270 334 0.013
monocarboxylic acid metabolic process GO:0032787 185 0.013
regulation of ketone biosynthetic process GO:0010566 7 0.013
interaction with host GO:0051701 42 0.013
protein maturation GO:0051604 233 0.013
glycoprotein metabolic process GO:0009100 110 0.013
oxidoreduction coenzyme metabolic process GO:0006733 19 0.013
negative regulation of multicellular organismal process GO:0051241 317 0.013
signal transduction by phosphorylation GO:0023014 297 0.013
secretion GO:0046903 254 0.013
protein processing GO:0016485 226 0.013
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 0.013
positive regulation of hydrolase activity GO:0051345 331 0.013
regulation of cellular component biogenesis GO:0044087 281 0.013
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.013
rna export from nucleus GO:0006405 33 0.013
alcohol biosynthetic process GO:0046165 52 0.012
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.012
positive regulation of cell death GO:0010942 263 0.012
inorganic cation transmembrane transport GO:0098662 194 0.012
rna localization GO:0006403 41 0.012
regulation of protein localization to cell surface GO:2000008 15 0.012
receptor metabolic process GO:0043112 81 0.012
cation transport GO:0006812 331 0.012
guanosine containing compound metabolic process GO:1901068 244 0.012
positive regulation of nucleocytoplasmic transport GO:0046824 54 0.012
negative regulation of protein transport GO:0051224 75 0.012
peptidyl tyrosine modification GO:0018212 170 0.012
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 45 0.012
cell development GO:0048468 328 0.012
positive regulation of proteasomal protein catabolic process GO:1901800 35 0.012
regulation of ion transport GO:0043269 189 0.012
regulation of cellular amino acid metabolic process GO:0006521 6 0.012
cell morphogenesis GO:0000902 296 0.012
positive regulation of protein catabolic process GO:0045732 75 0.012
negative regulation of cellular amine metabolic process GO:0033239 3 0.012
negative regulation of sodium ion transport GO:0010766 3 0.012
ubiquitin dependent smad protein catabolic process GO:0030579 4 0.012
negative regulation of sodium ion transmembrane transport GO:1902306 2 0.012
lipid localization GO:0010876 106 0.012
response to cytokine GO:0034097 232 0.012
ribonucleoside triphosphate metabolic process GO:0009199 412 0.012
tube morphogenesis GO:0035239 95 0.012
cellular protein complex assembly GO:0043623 188 0.012
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.011
regulation of immune response GO:0050776 201 0.011
intracellular steroid hormone receptor signaling pathway GO:0030518 61 0.011
organonitrogen compound biosynthetic process GO:1901566 200 0.011
ribosomal subunit export from nucleus GO:0000054 4 0.011
regulation of synaptic plasticity GO:0048167 3 0.011
negative regulation of cell differentiation GO:0045596 171 0.011
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.011
cellular response to oxidative stress GO:0034599 85 0.011
regeneration GO:0031099 4 0.011
intracellular receptor signaling pathway GO:0030522 104 0.011
negative regulation of phosphorus metabolic process GO:0010563 267 0.011
double strand break repair via homologous recombination GO:0000724 50 0.011
regulation of homeostatic process GO:0032844 121 0.011
nuclear export GO:0051168 69 0.011
response to metal ion GO:0010038 84 0.011
late endosome to vacuole transport GO:0045324 2 0.011
regulation of protein maturation GO:1903317 150 0.011
negative regulation of protein modification process GO:0031400 200 0.011
fatty acid biosynthetic process GO:0006633 46 0.011
cellular component morphogenesis GO:0032989 314 0.011
meiotic chromosome segregation GO:0045132 4 0.011
negative regulation of immune effector process GO:0002698 38 0.011
regulation of membrane potential GO:0042391 95 0.011
regulation of endocytosis GO:0030100 72 0.011
negative regulation of transferase activity GO:0051348 124 0.011
sodium ion transport GO:0006814 61 0.011
endosome transport via multivesicular body sorting pathway GO:0032509 3 0.011
cellular response to cytokine stimulus GO:0071345 181 0.011
regulation of chromosome organization GO:0033044 103 0.011
positive regulation of immune system process GO:0002684 283 0.011
negative regulation of myeloid cell differentiation GO:0045638 42 0.011
regulation of lipid biosynthetic process GO:0046890 47 0.011
positive regulation of nucleotide metabolic process GO:0045981 230 0.011
phosphatidylinositol 3 kinase signaling GO:0014065 48 0.011
viral genome replication GO:0019079 50 0.010
alcohol metabolic process GO:0006066 114 0.010
positive regulation of kinase activity GO:0033674 204 0.010
anatomical structure formation involved in morphogenesis GO:0048646 284 0.010
mrna export from nucleus GO:0006406 29 0.010
positive regulation of phosphatidylinositol 3 kinase signaling GO:0014068 28 0.010
regulation of growth GO:0040008 165 0.010
ncrna metabolic process GO:0034660 108 0.010
response to organic cyclic compound GO:0014070 204 0.010
positive regulation of multi organism process GO:0043902 56 0.010
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.010
neuron development GO:0048666 113 0.010
lymphocyte activation GO:0046649 133 0.010
photoreceptor cell differentiation GO:0046530 2 0.010
ribonucleoprotein complex export from nucleus GO:0071426 4 0.010
regulation of anatomical structure size GO:0090066 101 0.010
ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway GO:0043162 10 0.010
regulation of mrna export from nucleus GO:0010793 3 0.010
nucleosome organization GO:0034728 66 0.010
epithelium development GO:0060429 227 0.010
nucleoside phosphate catabolic process GO:1901292 412 0.010
negative regulation of protein processing GO:0010955 142 0.010
dolichol biosynthetic process GO:0019408 1 0.010
adult locomotory behavior GO:0008344 1 0.010

ERCC6 disease predictions

Disease DO term ID Size Probability Func Analog Org
xeroderma pigmentosum DOID:0050427 8 0.027
central nervous system disease DOID:331 186 0.026
nervous system disease DOID:863 431 0.026
sensory system disease DOID:0050155 203 0.025
cancer DOID:162 167 0.018
disease of cellular proliferation DOID:14566 174 0.018
retinal disease DOID:5679 118 0.017
eye and adnexa disease DOID:1492 150 0.017
eye disease DOID:5614 149 0.017
neurodegenerative disease DOID:1289 102 0.017
disease of metabolism DOID:0014667 295 0.012
organ system cancer DOID:0050686 164 0.011
retinal degeneration DOID:8466 89 0.005
macular degeneration DOID:4448 20 0.001
respiratory system cancer DOID:0050615 16 0.001
lung cancer DOID:1324 16 0.001
degeneration of macula and posterior pole DOID:2007 17 0.001
age related macular degeneration DOID:10871 17 0.001