Homo sapiens

0 known processes

EXOSC1

exosome component 1

(Aliases: Csl4p,hCsl4p,CGI-108,SKI4,Ski4p,p13,CSL4)

EXOSC1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
nuclear transcribed mrna catabolic process exonucleolytic GO:0000291 7 1.000
Yeast
rna phosphodiester bond hydrolysis exonucleolytic GO:0090503 14 0.998
Yeast
snrna metabolic process GO:0016073 15 0.994
dna deamination GO:0045006 9 0.896
trna catabolic process GO:0016078 1 0.872
Yeast
nuclear rna surveillance GO:0071027 4 0.860
Yeast
polyadenylation dependent rna catabolic process GO:0043633 3 0.816
Yeast
rrna catabolic process GO:0016075 6 0.618
Yeast
maturation of 5 8s rrna GO:0000460 8 0.605
Yeast
gtp catabolic process GO:0006184 237 0.580
maturation of 5 8s rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:0000466 2 0.576
Yeast
exonucleolytic nuclear transcribed mrna catabolic process involved in deadenylation dependent decay GO:0043928 6 0.545
glycosyl compound catabolic process GO:1901658 413 0.527
nuclear polyadenylation dependent rrna catabolic process GO:0071035 2 0.499
Yeast
cut metabolic process GO:0071043 3 0.497
organophosphate catabolic process GO:0046434 430 0.466
nucleoside triphosphate metabolic process GO:0009141 422 0.458
nuclear polyadenylation dependent ncrna catabolic process GO:0071046 2 0.440
Yeast
polyadenylation dependent ncrna catabolic process GO:0043634 2 0.398
Yeast
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.396
Yeast
purine ribonucleoside catabolic process GO:0046130 398 0.365
gtp metabolic process GO:0046039 239 0.341
rna phosphodiester bond hydrolysis GO:0090501 35 0.338
Yeast
positive regulation of catabolic process GO:0009896 310 0.338
dna modification GO:0006304 27 0.332
modification dependent macromolecule catabolic process GO:0043632 212 0.332
Yeast
rna processing GO:0006396 255 0.303
Yeast
rna surveillance GO:0071025 5 0.259
Yeast
defense response to other organism GO:0098542 129 0.236
rna catabolic process GO:0006401 71 0.233
Yeast
trna metabolic process GO:0006399 35 0.229
Yeast
determination of adult lifespan GO:0008340 2 0.229
rna 3 end processing GO:0031123 35 0.224
Yeast
guanosine containing compound metabolic process GO:1901068 244 0.222
snrna processing GO:0016180 14 0.214
rrna metabolic process GO:0016072 40 0.212
Yeast
mrna catabolic process GO:0006402 56 0.211
Yeast
ncrna catabolic process GO:0034661 14 0.205
Yeast
cellular macromolecule catabolic process GO:0044265 380 0.191
Yeast
ncrna 3 end processing GO:0043628 4 0.190
Yeast
multicellular organismal aging GO:0010259 3 0.184
purine nucleoside triphosphate catabolic process GO:0009146 392 0.183
response to external biotic stimulus GO:0043207 261 0.182
post embryonic development GO:0009791 2 0.181
nucleoside phosphate catabolic process GO:1901292 412 0.176
cut catabolic process GO:0071034 3 0.176
mrna metabolic process GO:0016071 175 0.174
Yeast
nuclear ncrna surveillance GO:0071029 2 0.171
Yeast
ncrna metabolic process GO:0034660 108 0.155
Yeast
ribonucleoside triphosphate metabolic process GO:0009199 412 0.143
ribonucleoprotein complex biogenesis GO:0022613 116 0.127
Yeast
regulation of nucleotide catabolic process GO:0030811 205 0.120
response to virus GO:0009615 126 0.110
response to other organism GO:0051707 261 0.109
positive regulation of cell growth GO:0030307 48 0.107
dna catabolic process endonucleolytic GO:0000737 37 0.101
positive regulation of cellular catabolic process GO:0031331 284 0.095
cellular component disassembly GO:0022411 92 0.095
defense response GO:0006952 315 0.093
positive regulation of hydrolase activity GO:0051345 331 0.090
regulation of gtpase activity GO:0043087 180 0.084
ribonucleoside catabolic process GO:0042454 406 0.082
positive regulation of nucleotide metabolic process GO:0045981 230 0.081
guanosine containing compound catabolic process GO:1901069 239 0.075
nuclear transcribed mrna catabolic process deadenylation dependent decay GO:0000288 14 0.074
purine nucleoside triphosphate metabolic process GO:0009144 412 0.073
defense response to virus GO:0051607 71 0.072
apoptotic dna fragmentation GO:0006309 6 0.072
amine metabolic process GO:0009308 44 0.068
response to biotic stimulus GO:0009607 276 0.067
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.066
regulation of purine nucleotide metabolic process GO:1900542 264 0.065
regulation of gtp catabolic process GO:0033124 180 0.065
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.064
cellular lipid metabolic process GO:0044255 303 0.062
purine ribonucleoside metabolic process GO:0046128 437 0.060
ribosome biogenesis GO:0042254 48 0.059
Yeast
purine nucleotide catabolic process GO:0006195 405 0.059
nucleoside triphosphate catabolic process GO:0009143 394 0.058
nucleoside catabolic process GO:0009164 408 0.056
regulation of nucleotide metabolic process GO:0006140 269 0.056
neurogenesis GO:0022008 169 0.051
nucleotide catabolic process GO:0009166 408 0.050
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.050
purine ribonucleotide catabolic process GO:0009154 404 0.049
regulation of cellular amino acid metabolic process GO:0006521 6 0.048
positive regulation of nucleotide catabolic process GO:0030813 185 0.048
nervous system development GO:0007399 293 0.047
immune effector process GO:0002252 159 0.047
purine containing compound catabolic process GO:0072523 411 0.047
vesicle mediated transport GO:0016192 371 0.046
nuclear transcribed mrna catabolic process GO:0000956 48 0.046
Yeast
rrna processing GO:0006364 35 0.045
Yeast
positive regulation of dna metabolic process GO:0051054 73 0.043
lipid metabolic process GO:0006629 381 0.042
regulation of cellular amine metabolic process GO:0033238 11 0.041
positive regulation of gtp catabolic process GO:0033126 166 0.041
regulation of cellular ketone metabolic process GO:0010565 50 0.038
glycerophospholipid metabolic process GO:0006650 84 0.038
regulation of nucleoside metabolic process GO:0009118 209 0.037
regulation of purine nucleotide catabolic process GO:0033121 205 0.037
regulation of growth GO:0040008 165 0.036
regulation of cell growth GO:0001558 135 0.036
cellular ketone metabolic process GO:0042180 80 0.036
ribonucleoside triphosphate catabolic process GO:0009203 391 0.036
negative regulation of phosphate metabolic process GO:0045936 267 0.034
cellular amine metabolic process GO:0044106 41 0.033
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.033
intracellular mrna localization GO:0008298 1 0.033
cellular amino acid metabolic process GO:0006520 116 0.031
small molecule biosynthetic process GO:0044283 157 0.031
histone mrna metabolic process GO:0008334 13 0.031
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.030
immune response GO:0006955 307 0.030
protein maturation GO:0051604 233 0.029
positive regulation of nucleoside metabolic process GO:0045979 186 0.028
negative regulation of phosphorus metabolic process GO:0010563 267 0.028
negative regulation of cellular protein metabolic process GO:0032269 353 0.028
positive regulation of cellular amine metabolic process GO:0033240 7 0.027
ribonucleotide catabolic process GO:0009261 405 0.027
neurological system process GO:0050877 163 0.027
cytoplasmic transport GO:0016482 379 0.027
nuclear mrna surveillance GO:0071028 4 0.025
cellular macromolecular complex assembly GO:0034622 324 0.025
purine nucleoside catabolic process GO:0006152 398 0.025
histone mrna catabolic process GO:0071044 10 0.025
negative regulation of catalytic activity GO:0043086 335 0.025
negative regulation of protein metabolic process GO:0051248 391 0.025
glycerolipid metabolic process GO:0046486 107 0.024
regeneration GO:0031099 4 0.024
regulation of transferase activity GO:0051338 355 0.024
regulation of dna metabolic process GO:0051052 153 0.024
organic hydroxy compound metabolic process GO:1901615 147 0.023
regulation of kinase activity GO:0043549 314 0.023
mitotic cell cycle GO:0000278 326 0.023
chromatin modification GO:0016568 298 0.021
dephosphorylation GO:0016311 209 0.021
oogenesis GO:0048477 2 0.021
transmembrane transport GO:0055085 399 0.021
positive regulation of gtpase activity GO:0043547 166 0.021
endocytosis GO:0006897 159 0.020
regulation of protein localization GO:0032880 296 0.020
regulation of proteolysis GO:0030162 293 0.020
negative regulation of cellular amine metabolic process GO:0033239 3 0.020
regulation of establishment of protein localization GO:0070201 242 0.020
oxidation reduction process GO:0055114 396 0.020
neuromuscular junction development GO:0007528 3 0.019
positive regulation of transport GO:0051050 336 0.019
regulation of membrane potential GO:0042391 95 0.019
mitochondrion organization GO:0007005 156 0.019
mitotic cell cycle process GO:1903047 286 0.019
female gamete generation GO:0007292 2 0.019
covalent chromatin modification GO:0016569 254 0.019
neuronal action potential GO:0019228 9 0.019
growth GO:0040007 202 0.019
cellular response to dna damage stimulus GO:0006974 379 0.018
cation transport GO:0006812 331 0.018
inorganic cation transmembrane transport GO:0098662 194 0.018
rho protein signal transduction GO:0007266 26 0.018
positive regulation of programmed cell death GO:0043068 249 0.018
system process GO:0003008 349 0.018
positive regulation of apoptotic process GO:0043065 246 0.018
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.018
cytokine production GO:0001816 247 0.018
regulation of intracellular transport GO:0032386 195 0.018
chemical homeostasis GO:0048878 306 0.018
membrane organization GO:0061024 292 0.017
ion homeostasis GO:0050801 230 0.017
ras protein signal transduction GO:0007265 73 0.017
segmentation GO:0035282 4 0.017
single organism carbohydrate metabolic process GO:0044723 193 0.017
nitrogen compound transport GO:0071705 191 0.017
single organism cellular localization GO:1902580 332 0.017
small gtpase mediated signal transduction GO:0007264 78 0.017
memory GO:0007613 3 0.017
leukocyte activation GO:0045321 164 0.017
nucleocytoplasmic transport GO:0006913 176 0.017
positive regulation of cell proliferation GO:0008284 301 0.016
execution phase of apoptosis GO:0097194 32 0.016
cellular protein complex assembly GO:0043623 188 0.016
negative regulation of protein modification process GO:0031400 200 0.016
blastoderm segmentation GO:0007350 2 0.016
positive regulation of phosphorylation GO:0042327 394 0.016
cellular homeostasis GO:0019725 196 0.016
polyadenylation dependent mrna catabolic process GO:0071047 1 0.016
regulation of protein serine threonine kinase activity GO:0071900 179 0.016
locomotory behavior GO:0007626 1 0.016
ion transmembrane transport GO:0034220 338 0.016
carbohydrate metabolic process GO:0005975 207 0.016
positive regulation of immune system process GO:0002684 283 0.016
negative regulation of phosphorylation GO:0042326 174 0.016
protein catabolic process GO:0030163 325 0.016
peripheral nervous system development GO:0007422 2 0.016
positive regulation of organelle organization GO:0010638 195 0.016
cell growth GO:0016049 160 0.016
dna catabolic process GO:0006308 49 0.015
organic hydroxy compound biosynthetic process GO:1901617 71 0.015
regulation of protein kinase activity GO:0045859 289 0.015
response to oxygen containing compound GO:1901700 369 0.015
regulation of cellular component movement GO:0051270 334 0.015
positive regulation of cellular component organization GO:0051130 376 0.015
cardiac muscle cell contraction GO:0086003 4 0.015
viral process GO:0016032 146 0.015
reactive oxygen species biosynthetic process GO:1903409 4 0.015
regulation of endopeptidase activity GO:0052548 170 0.015
protein ubiquitination GO:0016567 314 0.015
regulation of immune response GO:0050776 201 0.015
nuclear transport GO:0051169 179 0.015
positive regulation of mapk cascade GO:0043410 190 0.015
apoptotic signaling pathway GO:0097190 268 0.015
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.015
nerve development GO:0021675 4 0.015
actin filament based process GO:0030029 224 0.015
response to abiotic stimulus GO:0009628 336 0.015
cellular protein catabolic process GO:0044257 261 0.015
regulation of locomotion GO:0040012 329 0.015
regulation of protein processing GO:0070613 150 0.014
regulation of anatomical structure morphogenesis GO:0022603 286 0.014
negative regulation of intracellular signal transduction GO:1902532 183 0.014
protein targeting GO:0006605 187 0.014
phagocytosis GO:0006909 42 0.014
negative regulation of cellular component organization GO:0051129 235 0.014
hindbrain development GO:0030902 3 0.014
regulation of defense response GO:0031347 154 0.014
adult locomotory behavior GO:0008344 1 0.014
regulation of cellular response to stress GO:0080135 244 0.014
negative regulation of protein phosphorylation GO:0001933 140 0.014
morphogenesis of embryonic epithelium GO:0016331 4 0.014
spermatid differentiation GO:0048515 4 0.014
regulation of mapk cascade GO:0043408 262 0.014
carbohydrate derivative biosynthetic process GO:1901137 207 0.014
ncrna processing GO:0034470 83 0.014
Yeast
organelle fission GO:0048285 149 0.014
positive regulation of cell death GO:0010942 263 0.014
secretion by cell GO:0032940 226 0.014
single organism membrane organization GO:0044802 268 0.014
regulation of protein maturation GO:1903317 150 0.014
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.013
reactive nitrogen species metabolic process GO:2001057 3 0.013
phospholipid metabolic process GO:0006644 99 0.013
cation homeostasis GO:0055080 189 0.013
metal ion transport GO:0030001 272 0.013
tissue regeneration GO:0042246 3 0.013
negative regulation of programmed cell death GO:0043069 321 0.013
regulation of mitotic cell cycle GO:0007346 189 0.013
positive regulation of growth GO:0045927 58 0.013
embryonic epithelial tube formation GO:0001838 4 0.013
associative learning GO:0008306 1 0.013
divalent inorganic cation transport GO:0072511 158 0.013
regulation of response to external stimulus GO:0032101 222 0.013
signal transduction by phosphorylation GO:0023014 297 0.013
positive regulation of protein phosphorylation GO:0001934 313 0.013
interspecies interaction between organisms GO:0044419 156 0.013
histone modification GO:0016570 251 0.013
rna interference GO:0016246 4 0.013
motor neuron axon guidance GO:0008045 2 0.013
cellular metal ion homeostasis GO:0006875 146 0.013
release of cytoplasmic sequestered nf kappab GO:0008588 4 0.013
lipid catabolic process GO:0016042 84 0.013
regulation of cell cycle process GO:0010564 266 0.013
cation transmembrane transport GO:0098655 238 0.013
innate immune response GO:0045087 178 0.013
regulation of cytokine production GO:0001817 232 0.013
regulation of protein catabolic process GO:0042176 155 0.013
lipid biosynthetic process GO:0008610 177 0.013
calcium ion transport GO:0006816 147 0.013
cellular response to cytokine stimulus GO:0071345 181 0.013
negative regulation of proteolysis GO:0045861 132 0.012
lipid modification GO:0030258 84 0.012
cellular cation homeostasis GO:0030003 163 0.012
negative regulation of transferase activity GO:0051348 124 0.012
regulation of meiotic cell cycle GO:0051445 4 0.012
regulation of protein transport GO:0051223 213 0.012
regulation of cytoplasmic transport GO:1903649 149 0.012
actin mediated cell contraction GO:0070252 12 0.012
viral life cycle GO:0019058 132 0.012
anterior posterior axis specification GO:0009948 2 0.012
compound eye development GO:0048749 1 0.012
purine nucleoside monophosphate metabolic process GO:0009126 186 0.012
cell projection organization GO:0030030 252 0.012
membrane lipid metabolic process GO:0006643 53 0.012
organophosphate biosynthetic process GO:0090407 163 0.012
oocyte development GO:0048599 1 0.012
response to axon injury GO:0048678 1 0.012
syncytium formation by plasma membrane fusion GO:0000768 2 0.012
negative regulation of cell proliferation GO:0008285 228 0.012
actin filament based movement GO:0030048 17 0.012
cellular ion homeostasis GO:0006873 168 0.012
embryo development GO:0009790 123 0.012
hemopoiesis GO:0030097 180 0.012
immune system development GO:0002520 195 0.012
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.012
organic acid biosynthetic process GO:0016053 97 0.012
response to fungus GO:0009620 4 0.012
glycoprotein metabolic process GO:0009100 110 0.012
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.012
thymus development GO:0048538 3 0.012
inner ear morphogenesis GO:0042472 4 0.012
cerebellum development GO:0021549 2 0.012
negative regulation of multicellular organismal process GO:0051241 317 0.012
enzyme linked receptor protein signaling pathway GO:0007167 303 0.012
snorna metabolic process GO:0016074 1 0.012
regulation of peptidase activity GO:0052547 180 0.012
inorganic ion transmembrane transport GO:0098660 231 0.012
secretion GO:0046903 254 0.012
cell adhesion GO:0007155 325 0.011
regulation of multi organism process GO:0043900 157 0.011
biological adhesion GO:0022610 331 0.011
visual behavior GO:0007632 2 0.011
organ formation GO:0048645 3 0.011
anterior posterior axis specification embryo GO:0008595 2 0.011
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.011
peptidyl tyrosine modification GO:0018212 170 0.011
sequestering of metal ion GO:0051238 24 0.011
regulation of chromosome organization GO:0033044 103 0.011
negative regulation of hydrolase activity GO:0051346 182 0.011
chromosome segregation GO:0007059 114 0.011
limbic system development GO:0021761 3 0.011
alcohol biosynthetic process GO:0046165 52 0.011
nuclear transcribed mrna catabolic process nonsense mediated decay GO:0000184 23 0.011
head development GO:0060322 108 0.011
establishment of protein localization to organelle GO:0072594 172 0.011
regulation of cell motility GO:2000145 299 0.011
rhythmic behavior GO:0007622 2 0.011
maintenance of location GO:0051235 112 0.011
regulation of protein complex assembly GO:0043254 147 0.011
microtubule based process GO:0007017 210 0.011
positive regulation of immune response GO:0050778 159 0.011
negative regulation of protein kinase activity GO:0006469 98 0.011
photoreceptor cell differentiation GO:0046530 2 0.011
spermatid development GO:0007286 4 0.011
metal ion homeostasis GO:0055065 169 0.011
protein processing GO:0016485 226 0.011
morphogenesis of a polarized epithelium GO:0001738 3 0.011
multi organism cellular process GO:0044764 156 0.011
negative regulation of kinase activity GO:0033673 106 0.011
regulation of small gtpase mediated signal transduction GO:0051056 156 0.011
negative regulation of cell cycle GO:0045786 193 0.011
intracellular protein transport GO:0006886 270 0.011
protein alkylation GO:0008213 74 0.011
neurotransmitter secretion GO:0007269 4 0.011
mitotic cell cycle phase transition GO:0044772 162 0.011
tripartite regional subdivision GO:0007351 2 0.011
hematopoietic or lymphoid organ development GO:0048534 186 0.011
regulation of secretion GO:0051046 194 0.011
posttranscriptional regulation of gene expression GO:0010608 213 0.011
metencephalon development GO:0022037 2 0.011
positive regulation of cytokine production GO:0001819 167 0.011
cell morphogenesis GO:0000902 296 0.011
protein localization to membrane GO:0072657 160 0.011
regulation of cell migration GO:0030334 289 0.011
salivary gland morphogenesis GO:0007435 4 0.011
positive regulation of cell migration GO:0030335 172 0.010
protein acylation GO:0043543 138 0.010
protein modification by small protein conjugation GO:0032446 342 0.010
regulation of neural precursor cell proliferation GO:2000177 4 0.010
monocarboxylic acid metabolic process GO:0032787 185 0.010
macromolecule methylation GO:0043414 97 0.010
peptidyl tyrosine phosphorylation GO:0018108 170 0.010
cell fate determination GO:0001709 3 0.010
endosomal transport GO:0016197 129 0.010
negative regulation of organelle organization GO:0010639 126 0.010
cell activation GO:0001775 213 0.010
dosage compensation GO:0007549 3 0.010
t cell differentiation in thymus GO:0033077 4 0.010
monovalent inorganic cation transport GO:0015672 128 0.010
cellular response to endogenous stimulus GO:0071495 336 0.010
regulation of ras gtpase activity GO:0032318 128 0.010
ubiquitin dependent protein catabolic process GO:0006511 206 0.010
positive regulation of cellular component movement GO:0051272 181 0.010
negative regulation of cell growth GO:0030308 83 0.010
mapk cascade GO:0000165 288 0.010
actin cytoskeleton organization GO:0030036 207 0.010
circadian behavior GO:0048512 2 0.010
regulation of synaptic plasticity GO:0048167 3 0.010
positive regulation of cell motility GO:2000147 177 0.010
atp metabolic process GO:0046034 176 0.010
regulation of nuclease activity GO:0032069 11 0.010
organelle assembly GO:0070925 176 0.010
peptidyl lysine modification GO:0018205 144 0.010
nucleoside monophosphate catabolic process GO:0009125 159 0.010
sensory perception of pain GO:0019233 4 0.010
regulation of methylation dependent chromatin silencing GO:0090308 3 0.010
positive regulation of cellular component biogenesis GO:0044089 158 0.010
positive regulation of protein transport GO:0051222 135 0.010
regulation of meiosis GO:0040020 3 0.010
polyol metabolic process GO:0019751 32 0.010
positive regulation of cell cycle GO:0045787 140 0.010
cranial nerve development GO:0021545 4 0.010

EXOSC1 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.032
inherited metabolic disorder DOID:655 242 0.032
central nervous system disease DOID:331 186 0.030
nervous system disease DOID:863 431 0.030
musculoskeletal system disease DOID:17 223 0.023
disease of cellular proliferation DOID:14566 174 0.017
cancer DOID:162 167 0.016
sensory system disease DOID:0050155 203 0.015
eye and adnexa disease DOID:1492 150 0.015
eye disease DOID:5614 149 0.015
organ system cancer DOID:0050686 164 0.015
connective tissue disease DOID:65 109 0.015
bone disease DOID:0080001 88 0.014
immune system disease DOID:2914 155 0.012
muscular disease DOID:0080000 114 0.012
muscle tissue disease DOID:66 113 0.012
disease of mental health DOID:150 70 0.011
cardiovascular system disease DOID:1287 106 0.011
brain disease DOID:936 73 0.010