Homo sapiens

69 known processes

EXOSC10

exosome component 10

(Aliases: p2,p3,PMSCL,p4,RRP6,PM/Scl-100,Rrp6p,PM-Scl,PMSCL2)

EXOSC10 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
rna phosphodiester bond hydrolysis exonucleolytic GO:0090503 14 1.000
nuclear transcribed mrna catabolic process exonucleolytic GO:0000291 7 1.000
rna phosphodiester bond hydrolysis GO:0090501 35 0.998
snrna metabolic process GO:0016073 15 0.998
Yeast
maturation of 5 8s rrna GO:0000460 8 0.994
ncrna catabolic process GO:0034661 14 0.991
rna catabolic process GO:0006401 71 0.987
nuclear ncrna surveillance GO:0071029 2 0.982
polyadenylation dependent rna catabolic process GO:0043633 3 0.982
nuclear rna surveillance GO:0071027 4 0.981
rrna metabolic process GO:0016072 40 0.980
maturation of 5 8s rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:0000466 2 0.963
Yeast
cellular macromolecule catabolic process GO:0044265 380 0.963
nuclear polyadenylation dependent rrna catabolic process GO:0071035 2 0.957
trna catabolic process GO:0016078 1 0.955
Yeast
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.955
exonucleolytic nuclear transcribed mrna catabolic process involved in deadenylation dependent decay GO:0043928 6 0.952
dna deamination GO:0045006 9 0.938
ncrna metabolic process GO:0034660 108 0.930
nuclear polyadenylation dependent ncrna catabolic process GO:0071046 2 0.914
ribonucleoprotein complex biogenesis GO:0022613 116 0.913
nuclear transcribed mrna catabolic process GO:0000956 48 0.912
positive regulation of nucleotide metabolic process GO:0045981 230 0.907
rrna catabolic process GO:0016075 6 0.875
post embryonic development GO:0009791 2 0.863
Worm
dna modification GO:0006304 27 0.807
polyadenylation dependent ncrna catabolic process GO:0043634 2 0.798
ncrna processing GO:0034470 83 0.790
nucleoside phosphate catabolic process GO:1901292 412 0.716
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.696
positive regulation of gtpase activity GO:0043547 166 0.695
positive regulation of cellular catabolic process GO:0031331 284 0.680
guanosine containing compound metabolic process GO:1901068 244 0.671
gtp metabolic process GO:0046039 239 0.656
ribosome biogenesis GO:0042254 48 0.641
organophosphate catabolic process GO:0046434 430 0.617
ncrna 3 end processing GO:0043628 4 0.588
Yeast
ribonucleoside triphosphate metabolic process GO:0009199 412 0.575
cut metabolic process GO:0071043 3 0.539
purine ribonucleoside catabolic process GO:0046130 398 0.536
negative regulation of posttranscriptional gene silencing GO:0060149 3 0.535
positive regulation of catabolic process GO:0009896 310 0.475
regulation of nucleoside metabolic process GO:0009118 209 0.474
rna surveillance GO:0071025 5 0.451
positive regulation of nucleoside metabolic process GO:0045979 186 0.430
mrna metabolic process GO:0016071 175 0.414
nuclear transcribed mrna catabolic process deadenylation dependent decay GO:0000288 14 0.412
trna metabolic process GO:0006399 35 0.374
Yeast
nucleotide catabolic process GO:0009166 408 0.372
ribonucleoside catabolic process GO:0042454 406 0.359
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.358
glycosyl compound catabolic process GO:1901658 413 0.356
nucleoside triphosphate metabolic process GO:0009141 422 0.344
regulation of membrane potential GO:0042391 95 0.331
rna 3 end processing GO:0031123 35 0.315
Yeast
purine ribonucleoside metabolic process GO:0046128 437 0.311
response to external biotic stimulus GO:0043207 261 0.281
modification dependent macromolecule catabolic process GO:0043632 212 0.280
regulation of purine nucleotide catabolic process GO:0033121 205 0.279
mrna catabolic process GO:0006402 56 0.275
neuronal action potential GO:0019228 9 0.270
response to biotic stimulus GO:0009607 276 0.265
purine nucleotide catabolic process GO:0006195 405 0.252
regulation of nucleotide metabolic process GO:0006140 269 0.244
dna catabolic process GO:0006308 49 0.241
Worm
nucleoside triphosphate catabolic process GO:0009143 394 0.239
gtp catabolic process GO:0006184 237 0.232
rrna processing GO:0006364 35 0.226
defense response to other organism GO:0098542 129 0.206
regulation of gtp catabolic process GO:0033124 180 0.203
purine containing compound catabolic process GO:0072523 411 0.194
negative regulation of gene silencing by mirna GO:0060965 3 0.192
growth GO:0040007 202 0.191
Worm
snrna processing GO:0016180 14 0.189
Yeast
purine nucleoside catabolic process GO:0006152 398 0.188
positive regulation of hydrolase activity GO:0051345 331 0.187
positive regulation of gtp catabolic process GO:0033126 166 0.185
regulation of gtpase activity GO:0043087 180 0.182
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.180
cellular component disassembly GO:0022411 92 0.179
Worm
negative regulation of gene silencing by rna GO:0060967 3 0.175
rna processing GO:0006396 255 0.166
response to other organism GO:0051707 261 0.162
multicellular organismal aging GO:0010259 3 0.155
Worm
ribonucleotide catabolic process GO:0009261 405 0.144
cut catabolic process GO:0071034 3 0.144
defense response GO:0006952 315 0.126
polyadenylation dependent mrna catabolic process GO:0071047 1 0.125
Yeast
regulation of nucleotide catabolic process GO:0030811 205 0.122
transmission of nerve impulse GO:0019226 11 0.122
purine ribonucleotide catabolic process GO:0009154 404 0.120
positive regulation of cell growth GO:0030307 48 0.116
purine nucleoside triphosphate metabolic process GO:0009144 412 0.114
guanosine containing compound catabolic process GO:1901069 239 0.110
nucleoside catabolic process GO:0009164 408 0.108
nervous system development GO:0007399 293 0.097
neurogenesis GO:0022008 169 0.094
determination of adult lifespan GO:0008340 2 0.090
Worm
brain development GO:0007420 97 0.082
axon ensheathment GO:0008366 6 0.073
posttranscriptional regulation of gene expression GO:0010608 213 0.072
ribonucleoside triphosphate catabolic process GO:0009203 391 0.070
neurological system process GO:0050877 163 0.068
purine nucleoside triphosphate catabolic process GO:0009146 392 0.065
multicellular organismal signaling GO:0035637 34 0.064
head development GO:0060322 108 0.063
cell growth GO:0016049 160 0.057
mitotic cell cycle GO:0000278 326 0.057
histone mrna metabolic process GO:0008334 13 0.053
regulation of purine nucleotide metabolic process GO:1900542 264 0.052
defense response to bacterium GO:0042742 63 0.050
immune effector process GO:0002252 159 0.045
female gamete generation GO:0007292 2 0.044
action potential GO:0001508 34 0.044
dna catabolic process endonucleolytic GO:0000737 37 0.040
Worm
rna splicing GO:0008380 131 0.040
nuclear polyadenylation dependent mrna catabolic process GO:0071042 1 0.039
Yeast
regulation of growth GO:0040008 165 0.038
oogenesis GO:0048477 2 0.038
execution phase of apoptosis GO:0097194 32 0.038
Worm
system process GO:0003008 349 0.037
neuromuscular junction development GO:0007528 3 0.037
amine metabolic process GO:0009308 44 0.036
regulation of viral process GO:0050792 103 0.036
central nervous system development GO:0007417 123 0.035
regulation of cell cycle GO:0051726 393 0.034
cellular component morphogenesis GO:0032989 314 0.034
regulation of mitotic cell cycle GO:0007346 189 0.032
nuclear transcribed mrna catabolic process nonsense mediated decay GO:0000184 23 0.032
immune response GO:0006955 307 0.029
regulation of meiosis GO:0040020 3 0.029
rna polymerase ii transcriptional preinitiation complex assembly GO:0051123 4 0.029
regulation of cell growth GO:0001558 135 0.029
hindbrain development GO:0030902 3 0.029
cellular lipid metabolic process GO:0044255 303 0.028
intracellular mrna localization GO:0008298 1 0.028
ensheathment of neurons GO:0007272 6 0.026
viral transcription GO:0019083 35 0.026
positive regulation of cellular component organization GO:0051130 376 0.025
positive regulation of growth GO:0045927 58 0.025
regulation of meiotic cell cycle GO:0051445 4 0.024
glycerophospholipid metabolic process GO:0006650 84 0.024
cell projection organization GO:0030030 252 0.024
vesicle mediated transport GO:0016192 371 0.024
Worm
defense response to virus GO:0051607 71 0.024
cell development GO:0048468 328 0.023
regulation of protein complex assembly GO:0043254 147 0.023
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.023
regeneration GO:0031099 4 0.022
chromatin modification GO:0016568 298 0.022
response to virus GO:0009615 126 0.021
viral life cycle GO:0019058 132 0.021
locomotory behavior GO:0007626 1 0.021
adult locomotory behavior GO:0008344 1 0.021
regulation of cellular amino acid metabolic process GO:0006521 6 0.021
embryo development GO:0009790 123 0.021
Worm
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.021
histone modification GO:0016570 251 0.020
cell morphogenesis involved in differentiation GO:0000904 144 0.020
cellular ketone metabolic process GO:0042180 80 0.020
positive regulation of protein complex assembly GO:0031334 86 0.020
small gtpase mediated signal transduction GO:0007264 78 0.020
regulation of cellular amine metabolic process GO:0033238 11 0.019
cellular amine metabolic process GO:0044106 41 0.019
cellular response to growth factor stimulus GO:0071363 197 0.019
regulation of ras protein signal transduction GO:0046578 155 0.019
single organism reproductive process GO:0044702 98 0.019
regulation of gene silencing GO:0060968 24 0.018
regulation of cellular ketone metabolic process GO:0010565 50 0.018
endomembrane system organization GO:0010256 196 0.018
regulation of dna metabolic process GO:0051052 153 0.018
reproductive process GO:0022414 106 0.018
rho protein signal transduction GO:0007266 26 0.018
negative regulation of phosphorus metabolic process GO:0010563 267 0.018
biological adhesion GO:0022610 331 0.018
negative regulation of cellular protein metabolic process GO:0032269 353 0.017
mitotic cell cycle process GO:1903047 286 0.017
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.017
regulation of cytoskeleton organization GO:0051493 177 0.017
response to bacterium GO:0009617 144 0.017
response to growth factor GO:0070848 205 0.017
microtubule based process GO:0007017 210 0.016
regulation of proteolysis GO:0030162 293 0.016
chemotaxis GO:0006935 157 0.016
regulation of nuclear division GO:0051783 65 0.016
response to wounding GO:0009611 168 0.016
cell adhesion GO:0007155 325 0.016
male genitalia development GO:0030539 1 0.016
microtubule cytoskeleton organization GO:0000226 176 0.016
morphogenesis of a polarized epithelium GO:0001738 3 0.016
regulation of cellular response to stress GO:0080135 244 0.016
cellular amino acid metabolic process GO:0006520 116 0.016
enzyme linked receptor protein signaling pathway GO:0007167 303 0.015
negative regulation of protein metabolic process GO:0051248 391 0.015
wnt signaling pathway GO:0016055 156 0.015
positive regulation of dna metabolic process GO:0051054 73 0.015
spermatid differentiation GO:0048515 4 0.015
protein autophosphorylation GO:0046777 123 0.015
synaptic vesicle exocytosis GO:0016079 3 0.015
cell activation GO:0001775 213 0.015
positive regulation of cellular amine metabolic process GO:0033240 7 0.015
regulation of cell cycle process GO:0010564 266 0.015
cell morphogenesis GO:0000902 296 0.014
neuron development GO:0048666 113 0.014
cellular response to dna damage stimulus GO:0006974 379 0.014
glycerolipid metabolic process GO:0046486 107 0.014
lipid metabolic process GO:0006629 381 0.014
negative regulation of viral process GO:0048525 66 0.014
nucleoside monophosphate metabolic process GO:0009123 191 0.014
single organism cellular localization GO:1902580 332 0.014
regulation of gene silencing by mirna GO:0060964 6 0.014
regulation of protein transport GO:0051223 213 0.014
regulation of protein localization GO:0032880 296 0.014
small molecule biosynthetic process GO:0044283 157 0.013
multi organism cellular process GO:0044764 156 0.013
oxidation reduction process GO:0055114 396 0.013
tissue regeneration GO:0042246 3 0.013
negative regulation of phosphate metabolic process GO:0045936 267 0.013
oocyte development GO:0048599 1 0.013
blastocyst development GO:0001824 3 0.013
response to cytokine GO:0034097 232 0.013
stem cell division GO:0017145 2 0.013
wound healing GO:0042060 115 0.013
negative regulation of multicellular organismal process GO:0051241 317 0.013
single organismal cell cell adhesion GO:0016337 148 0.013
positive regulation of organelle organization GO:0010638 195 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.013
cardiac muscle cell contraction GO:0086003 4 0.013
protein alkylation GO:0008213 74 0.012
neurotransmitter secretion GO:0007269 4 0.012
phospholipid metabolic process GO:0006644 99 0.012
circulatory system development GO:0072359 262 0.012
single organism cell adhesion GO:0098602 179 0.012
snorna metabolic process GO:0016074 1 0.012
Yeast
vasculature development GO:0001944 181 0.012
regulation of chromosome organization GO:0033044 103 0.012
blastoderm segmentation GO:0007350 2 0.012
regulation of ras gtpase activity GO:0032318 128 0.012
innate immune response GO:0045087 178 0.012
negative regulation of immune system process GO:0002683 136 0.012
viral process GO:0016032 146 0.012
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.012
glial cell migration GO:0008347 4 0.012
regulation of small gtpase mediated signal transduction GO:0051056 156 0.012
negative regulation of cellular component organization GO:0051129 235 0.012
cellular protein catabolic process GO:0044257 261 0.012
regulation of intracellular transport GO:0032386 195 0.012
nuclear transport GO:0051169 179 0.012
protein localization to organelle GO:0033365 280 0.012
organic hydroxy compound metabolic process GO:1901615 147 0.012
actin filament based movement GO:0030048 17 0.012
spermatid development GO:0007286 4 0.011
endocytosis GO:0006897 159 0.011
Worm
negative regulation of catalytic activity GO:0043086 335 0.011
ras protein signal transduction GO:0007265 73 0.011
carbohydrate derivative biosynthetic process GO:1901137 207 0.011
cell part morphogenesis GO:0032990 137 0.011
segmentation GO:0035282 4 0.011
positive regulation of transport GO:0051050 336 0.011
reproduction GO:0000003 63 0.011
secretion by cell GO:0032940 226 0.011
actin mediated cell contraction GO:0070252 12 0.011
response to fungus GO:0009620 4 0.011
apoptotic signaling pathway GO:0097190 268 0.011
negative regulation of multi organism process GO:0043901 92 0.011
positive regulation of protein transport GO:0051222 135 0.011
positive regulation of nucleotide catabolic process GO:0030813 185 0.011
regulation of cellular protein catabolic process GO:1903362 96 0.011
embryonic epithelial tube formation GO:0001838 4 0.011
membrane lipid metabolic process GO:0006643 53 0.011
regulation of protein catabolic process GO:0042176 155 0.011
secretion GO:0046903 254 0.011
positive regulation of transcription initiation from rna polymerase ii promoter GO:0060261 4 0.011
chromatin organization GO:0006325 351 0.011
protein deubiquitination GO:0016579 79 0.011
meiosis i GO:0007127 4 0.010
establishment or maintenance of cell polarity GO:0007163 31 0.010
regulation of binding GO:0051098 111 0.010
regulation of mapk cascade GO:0043408 262 0.010
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.010
epithelial cell proliferation GO:0050673 128 0.010
covalent chromatin modification GO:0016569 254 0.010
embryo development ending in birth or egg hatching GO:0009792 34 0.010
Worm
cell projection morphogenesis GO:0048858 129 0.010
tube closure GO:0060606 3 0.010
hematopoietic or lymphoid organ development GO:0048534 186 0.010
neural tube closure GO:0001843 3 0.010
methylation GO:0032259 106 0.010
generation of neurons GO:0048699 152 0.010
positive regulation of cell death GO:0010942 263 0.010
protein acylation GO:0043543 138 0.010
positive regulation of protein catabolic process GO:0045732 75 0.010
morphogenesis of embryonic epithelium GO:0016331 4 0.010
regulation of establishment of protein localization GO:0070201 242 0.010

EXOSC10 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.101
inherited metabolic disorder DOID:655 242 0.084
leigh disease DOID:3652 16 0.056
mitochondrial metabolism disease DOID:700 29 0.056
musculoskeletal system disease DOID:17 223 0.025
sensory system disease DOID:0050155 203 0.022
eye and adnexa disease DOID:1492 150 0.022
nervous system disease DOID:863 431 0.022
central nervous system disease DOID:331 186 0.020
neurodegenerative disease DOID:1289 102 0.011
disease of cellular proliferation DOID:14566 174 0.011
carbohydrate metabolic disorder DOID:2978 55 0.011