Homo sapiens

285 known processes

EZH2

enhancer of zeste homolog 2 (Drosophila)

(Aliases: ENX-1,MGC9169,KMT6,ENX1,EZH1,KMT6A)

EZH2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of histone h3 k27 methylation GO:0061085 4 0.998
chromatin modification GO:0016568 298 0.996
methylation dependent chromatin silencing GO:0006346 3 0.995
covalent chromatin modification GO:0016569 254 0.984
chromatin organization GO:0006325 351 0.980
macromolecule methylation GO:0043414 97 0.975
histone modification GO:0016570 251 0.958
histone lysine methylation GO:0034968 50 0.948
methylation GO:0032259 106 0.934
post embryonic development GO:0009791 2 0.836
Worm
purine ribonucleoside metabolic process GO:0046128 437 0.762
negative regulation of histone methylation GO:0031061 6 0.741
nuclear division GO:0000280 128 0.698
cellular response to growth factor stimulus GO:0071363 197 0.668
negative regulation of protein metabolic process GO:0051248 391 0.629
positive regulation of cellular component organization GO:0051130 376 0.609
cellular amino acid metabolic process GO:0006520 116 0.607
protein alkylation GO:0008213 74 0.598
negative regulation of developmental process GO:0051093 247 0.587
Mouse Worm
gene silencing GO:0016458 49 0.577
regulation of dna metabolic process GO:0051052 153 0.547
vesicle mediated transport GO:0016192 371 0.546
protein ubiquitination GO:0016567 314 0.545
negative regulation of protein modification process GO:0031400 200 0.528
embryo development GO:0009790 123 0.513
Fly
rostrocaudal neural tube patterning GO:0021903 1 0.505
negative regulation of histone h3 k9 methylation GO:0051573 3 0.502
regulation of histone methylation GO:0031060 16 0.502
neurogenesis GO:0022008 169 0.498
Mouse Fly
positive regulation of histone methylation GO:0031062 12 0.498
positive regulation of histone h3 k4 methylation GO:0051571 8 0.469
positive regulation of organelle organization GO:0010638 195 0.459
regulation of cell cycle GO:0051726 393 0.457
Mouse
response to abiotic stimulus GO:0009628 336 0.409
regulation of chromatin modification GO:1903308 51 0.397
oogenesis GO:0048477 2 0.395
small gtpase mediated signal transduction GO:0007264 78 0.395
mrna metabolic process GO:0016071 175 0.390
muscle structure development GO:0061061 98 0.388
Mouse Fly
sulfur compound metabolic process GO:0006790 101 0.366
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.363
response to radiation GO:0009314 151 0.357
regulation of cell cycle process GO:0010564 266 0.356
Mouse
positive regulation of chromosome organization GO:2001252 41 0.341
cell morphogenesis involved in differentiation GO:0000904 144 0.326
cellular component morphogenesis GO:0032989 314 0.304
negative regulation of cellular protein metabolic process GO:0032269 353 0.287
positive regulation of histone modification GO:0031058 29 0.282
negative regulation of cell differentiation GO:0045596 171 0.275
Mouse
receptor mediated endocytosis GO:0006898 84 0.263
negative regulation of cellular component organization GO:0051129 235 0.252
response to biotic stimulus GO:0009607 276 0.251
nervous system development GO:0007399 293 0.243
Mouse Fly
dna hypermethylation GO:0044026 1 0.243
organ morphogenesis GO:0009887 147 0.241
regulation of meiotic cell cycle GO:0051445 4 0.237
multicellular organismal aging GO:0010259 3 0.236
Worm
protein methylation GO:0006479 74 0.226
cell morphogenesis GO:0000902 296 0.216
cellular response to oxygen containing compound GO:1901701 276 0.216
Mouse
single organism cellular localization GO:1902580 332 0.213
response to oxygen containing compound GO:1901700 369 0.211
Mouse
protein modification by small protein conjugation GO:0032446 342 0.207
tube development GO:0035295 125 0.197
cell development GO:0048468 328 0.195
oocyte differentiation GO:0009994 2 0.193
mitotic cell cycle GO:0000278 326 0.184
Mouse Fly
histone methylation GO:0016571 60 0.170
response to ionizing radiation GO:0010212 65 0.168
myeloid cell differentiation GO:0030099 117 0.164
cell projection organization GO:0030030 252 0.162
Fly
ras protein signal transduction GO:0007265 73 0.159
cell part morphogenesis GO:0032990 137 0.153
Fly
rna processing GO:0006396 255 0.148
single organism reproductive process GO:0044702 98 0.142
Worm
reproductive system development GO:0061458 56 0.138
cytoplasmic transport GO:0016482 379 0.132
dna repair GO:0006281 198 0.130
regulation of gene expression epigenetic GO:0040029 73 0.125
internal protein amino acid acetylation GO:0006475 101 0.118
enzyme linked receptor protein signaling pathway GO:0007167 303 0.117
regulation of cell differentiation GO:0045595 393 0.117
alpha amino acid metabolic process GO:1901605 72 0.117
dna methylation on cytosine GO:0032776 3 0.116
negative regulation of chromatin modification GO:1903309 21 0.113
generation of neurons GO:0048699 152 0.112
Mouse Fly
regulation of cell development GO:0060284 161 0.110
cell division GO:0051301 168 0.105
Worm
neuron differentiation GO:0030182 138 0.104
Fly
microtubule cytoskeleton organization GO:0000226 176 0.100
response to external biotic stimulus GO:0043207 261 0.099
microtubule based process GO:0007017 210 0.098
purine nucleoside triphosphate metabolic process GO:0009144 412 0.097
coenzyme metabolic process GO:0006732 65 0.097
chromatin remodeling GO:0006338 55 0.095
regulation of nervous system development GO:0051960 88 0.090
Mouse
cellular modified amino acid metabolic process GO:0006575 64 0.090
blastocyst development GO:0001824 3 0.090
positive regulation of cell cycle GO:0045787 140 0.089
sex differentiation GO:0007548 45 0.088
reproduction GO:0000003 63 0.087
Worm
posttranscriptional regulation of gene expression GO:0010608 213 0.087
actin filament based process GO:0030029 224 0.085
neuron development GO:0048666 113 0.085
Fly
rna splicing GO:0008380 131 0.085
response to growth factor GO:0070848 205 0.084
mrna processing GO:0006397 133 0.084
endocytosis GO:0006897 159 0.083
histone h3 k4 methylation GO:0051568 27 0.083
regulation of cellular amine metabolic process GO:0033238 11 0.082
oocyte development GO:0048599 1 0.081
negative regulation of chromosome organization GO:2001251 48 0.079
positive regulation of chromatin modification GO:1903310 30 0.075
negative regulation of cell cycle GO:0045786 193 0.075
Mouse
positive regulation of cell cycle process GO:0090068 106 0.072
regulation of meiosis GO:0040020 3 0.071
neuron projection morphogenesis GO:0048812 50 0.071
Fly
histone h3 k9 methylation GO:0051567 10 0.069
Fly
regulation of cellular response to stress GO:0080135 244 0.069
response to lipid GO:0033993 206 0.069
response to bacterium GO:0009617 144 0.068
female gamete generation GO:0007292 2 0.066
mitotic nuclear division GO:0007067 119 0.065
response to drug GO:0042493 81 0.065
cellular response to oxygen levels GO:0071453 55 0.064
chromatin silencing GO:0006342 12 0.063
cellular macromolecular complex assembly GO:0034622 324 0.061
sodium ion export from cell GO:0036376 6 0.061
protein acylation GO:0043543 138 0.060
response to lead ion GO:0010288 1 0.059
determination of adult lifespan GO:0008340 2 0.057
Worm
embryo development ending in birth or egg hatching GO:0009792 34 0.057
response to alcohol GO:0097305 64 0.056
regulation of chromosome organization GO:0033044 103 0.054
peptidyl lysine acetylation GO:0018394 101 0.053
response to activity GO:0014823 0 0.053
regulation of circadian rhythm GO:0042752 11 0.052
negative regulation of multicellular organismal process GO:0051241 317 0.051
Mouse Worm
gamete generation GO:0007276 25 0.050
Worm
cellular response to endogenous stimulus GO:0071495 336 0.050
dna conformation change GO:0071103 113 0.049
cellular protein catabolic process GO:0044257 261 0.048
cellular response to dna damage stimulus GO:0006974 379 0.047
regulation of small gtpase mediated signal transduction GO:0051056 156 0.047
organelle fission GO:0048285 149 0.047
response to hyperoxia GO:0055093 4 0.046
negative regulation of programmed cell death GO:0043069 321 0.046
response to acid chemical GO:0001101 66 0.046
regulation of kinase activity GO:0043549 314 0.044
cartilage development GO:0051216 31 0.043
muscle cell differentiation GO:0042692 63 0.042
Mouse
regulation of multi organism process GO:0043900 157 0.042
regulation of mitotic recombination GO:0000019 1 0.042
dendrite development GO:0016358 24 0.040
Fly
mrna splicing via spliceosome GO:0000398 89 0.040
negative regulation of cell death GO:0060548 345 0.040
cellular macromolecule catabolic process GO:0044265 380 0.039
nitrogen compound transport GO:0071705 191 0.039
positive regulation of histone h3 k27 methylation GO:0061087 3 0.039
response to other organism GO:0051707 261 0.038
cellular response to lipid GO:0071396 127 0.038
response to fungus GO:0009620 4 0.037
regionalization GO:0003002 29 0.037
cellular response to acid chemical GO:0071229 44 0.036
neuron projection development GO:0031175 106 0.035
Fly
response to decreased oxygen levels GO:0036293 96 0.035
histone h3 k9 modification GO:0061647 11 0.034
Fly
response to steroid hormone GO:0048545 80 0.034
regulation of transferase activity GO:0051338 355 0.034
cardiovascular system development GO:0072358 262 0.033
pattern specification process GO:0007389 43 0.033
negative regulation of apoptotic process GO:0043066 316 0.032
maintenance of location GO:0051235 112 0.032
cell morphogenesis involved in neuron differentiation GO:0048667 44 0.032
Fly
meiotic cell cycle GO:0051321 13 0.032
dna methylation GO:0006306 7 0.032
Mouse
dephosphorylation GO:0016311 209 0.031
maintenance of protein location in cell GO:0032507 56 0.031
response to hypoxia GO:0001666 96 0.031
negative regulation of gene expression epigenetic GO:0045814 19 0.031
reproductive structure development GO:0048608 55 0.031
locomotory behavior GO:0007626 1 0.030
sensory organ morphogenesis GO:0090596 21 0.030
atp catabolic process GO:0006200 157 0.030
regulation of mrna splicing via spliceosome GO:0048024 32 0.029
histone ubiquitination GO:0016574 31 0.029
positive regulation of developmental process GO:0051094 314 0.029
regulation of cellular response to growth factor stimulus GO:0090287 76 0.029
regulation of dna replication GO:0006275 68 0.029
negative regulation of catalytic activity GO:0043086 335 0.029
regulation of protein transport GO:0051223 213 0.029
response to extracellular stimulus GO:0009991 85 0.029
protein catabolic process GO:0030163 325 0.029
spindle organization GO:0007051 53 0.028
defense response to other organism GO:0098542 129 0.028
immune effector process GO:0002252 159 0.028
modification dependent protein catabolic process GO:0019941 209 0.028
defense response to fungus GO:0050832 4 0.028
cell cycle phase transition GO:0044770 173 0.028
Mouse
cellular ketone metabolic process GO:0042180 80 0.027
regulation of mitotic cell cycle GO:0007346 189 0.027
Mouse
mitotic cell cycle process GO:1903047 286 0.026
Mouse
aging GO:0007568 66 0.026
Worm
regulation of protein localization GO:0032880 296 0.026
regulation of response to external stimulus GO:0032101 222 0.026
tube morphogenesis GO:0035239 95 0.026
purine nucleoside catabolic process GO:0006152 398 0.025
regulation of histone modification GO:0031056 47 0.025
chordate embryonic development GO:0043009 34 0.025
gland development GO:0048732 48 0.024
cellular response to organonitrogen compound GO:0071417 124 0.024
amine metabolic process GO:0009308 44 0.024
positive regulation of dna metabolic process GO:0051054 73 0.024
protein import GO:0017038 130 0.024
positive regulation of immune system process GO:0002684 283 0.024
cellular response to steroid hormone stimulus GO:0071383 37 0.024
regulation of dna repair GO:0006282 47 0.024
regulation of nuclear division GO:0051783 65 0.024
response to molecule of bacterial origin GO:0002237 82 0.024
developmental process involved in reproduction GO:0003006 66 0.023
Worm
regulation of histone h3 k4 methylation GO:0051569 10 0.023
organelle assembly GO:0070925 176 0.023
response to vitamin GO:0033273 13 0.023
regulation of ras protein signal transduction GO:0046578 155 0.022
intrinsic apoptotic signaling pathway GO:0097193 127 0.022
digestive tract development GO:0048565 75 0.022
cellular response to dexamethasone stimulus GO:0071549 1 0.022
regulation of cellular component biogenesis GO:0044087 281 0.022
response to nitrogen compound GO:1901698 184 0.022
biological adhesion GO:0022610 331 0.022
cofactor metabolic process GO:0051186 87 0.022
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.022
cell adhesion GO:0007155 325 0.021
reproductive process GO:0022414 106 0.021
Worm
negative regulation of protein phosphorylation GO:0001933 140 0.020
viral process GO:0016032 146 0.020
signal transduction by phosphorylation GO:0023014 297 0.020
response to caffeine GO:0031000 3 0.020
adaptive immune response GO:0002250 49 0.019
negative regulation of transferase activity GO:0051348 124 0.019
multicellular organismal reproductive process GO:0048609 40 0.019
Worm
epidermis development GO:0008544 59 0.019
Mouse
histone acetylation GO:0016573 93 0.018
regulation of protein serine threonine kinase activity GO:0071900 179 0.018
cell projection morphogenesis GO:0048858 129 0.018
Fly
regulation of dna methylation GO:0044030 2 0.018
hemopoiesis GO:0030097 180 0.017
angiogenesis GO:0001525 147 0.017
atp metabolic process GO:0046034 176 0.017
membrane organization GO:0061024 292 0.017
positive regulation of cell differentiation GO:0045597 211 0.017
regulation of mrna metabolic process GO:1903311 53 0.017
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.017
response to dexamethasone GO:0071548 1 0.017
hepaticobiliary system development GO:0061008 10 0.017
dosage compensation GO:0007549 3 0.017
vasculature development GO:0001944 181 0.016
oocyte maturation GO:0001556 1 0.016
system process GO:0003008 349 0.016
posttranscriptional gene silencing GO:0016441 25 0.016
multi organism cellular process GO:0044764 156 0.016
regulation of immune response GO:0050776 201 0.016
positive regulation of cell proliferation GO:0008284 301 0.016
negative regulation of protein maturation GO:1903318 142 0.015
mitotic cytokinesis GO:0000281 19 0.015
hindbrain development GO:0030902 3 0.015
Mouse
response to hormone GO:0009725 175 0.015
striated muscle cell differentiation GO:0051146 43 0.015
Mouse
cell activation GO:0001775 213 0.015
regulation of protein kinase activity GO:0045859 289 0.015
nucleoside phosphate catabolic process GO:1901292 412 0.015
spermatid differentiation GO:0048515 4 0.015
growth GO:0040007 202 0.015
Mouse
nucleotide catabolic process GO:0009166 408 0.015
regulation of locomotion GO:0040012 329 0.015
nucleoside triphosphate metabolic process GO:0009141 422 0.014
multicellular organism reproduction GO:0032504 42 0.014
Worm
nucleoside triphosphate catabolic process GO:0009143 394 0.014
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.014
gonad development GO:0008406 34 0.014
cellular response to nitrogen compound GO:1901699 144 0.014
negative regulation of organelle organization GO:0010639 126 0.014
male gamete generation GO:0048232 22 0.014
regulation of chromatin organization GO:1902275 56 0.014
peptidyl lysine modification GO:0018205 144 0.014
Fly
lipid localization GO:0010876 106 0.014
regulation of chromosome segregation GO:0051983 44 0.014
regulation of neurogenesis GO:0050767 82 0.014
Mouse
ribonucleoside monophosphate catabolic process GO:0009158 158 0.014
response to transforming growth factor beta GO:0071559 94 0.014
oxidation reduction process GO:0055114 396 0.014
purine containing compound catabolic process GO:0072523 411 0.013
regulation of protein complex assembly GO:0043254 147 0.013
endomembrane system organization GO:0010256 196 0.013
ribonucleoside triphosphate metabolic process GO:0009199 412 0.013
regulation of cell activation GO:0050865 125 0.013
negative regulation of hydrolase activity GO:0051346 182 0.013
leukocyte proliferation GO:0070661 74 0.013
rna splicing via transesterification reactions GO:0000375 90 0.013
developmental maturation GO:0021700 28 0.013
sex determination GO:0007530 3 0.013
response to purine containing compound GO:0014074 40 0.013
eye development GO:0001654 42 0.013
negative regulation of neuron projection development GO:0010977 15 0.013
spermatid development GO:0007286 4 0.013
neuromuscular junction development GO:0007528 3 0.012
positive regulation of nfat protein import into nucleus GO:0051533 3 0.012
regulation of adaptive immune response GO:0002819 33 0.012
intracellular protein transport GO:0006886 270 0.012
sexual reproduction GO:0019953 37 0.012
Worm
negative regulation of phosphate metabolic process GO:0045936 267 0.012
cellular response to hormone stimulus GO:0032870 125 0.012
immune system development GO:0002520 195 0.012
regulation of dna dependent dna replication GO:0090329 19 0.012
glycosyl compound catabolic process GO:1901658 413 0.012
single organism carbohydrate metabolic process GO:0044723 193 0.012
regulation of actin filament based process GO:0032970 141 0.012
development of primary sexual characteristics GO:0045137 35 0.012
apoptotic signaling pathway GO:0097190 268 0.011
negative regulation of kinase activity GO:0033673 106 0.011
protein dephosphorylation GO:0006470 81 0.011
cell type specific apoptotic process GO:0097285 125 0.011
circulatory system development GO:0072359 262 0.011
ribonucleotide catabolic process GO:0009261 405 0.011
regulation of protein catabolic process GO:0042176 155 0.011
response to toxic substance GO:0009636 37 0.011
establishment of protein localization to organelle GO:0072594 172 0.011
positive regulation of phosphorylation GO:0042327 394 0.011
regulation of cellular ketone metabolic process GO:0010565 50 0.011
regulation of neuron differentiation GO:0045664 70 0.011
regulation of mrna processing GO:0050684 48 0.011
negative regulation of phosphorylation GO:0042326 174 0.011
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 37 0.011
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.011
response to amino acid GO:0043200 14 0.011
regulation of cellular component movement GO:0051270 334 0.010
regulation of oocyte development GO:0060281 1 0.010
negative regulation of multi organism process GO:0043901 92 0.010
dna modification GO:0006304 27 0.010
Mouse
muscle system process GO:0003012 81 0.010
protein complex localization GO:0031503 31 0.010
dna replication GO:0006260 116 0.010
regulation of cell division GO:0051302 116 0.010

EZH2 disease predictions

Disease DO term ID Size Probability Func Analog Org
peripheral neuropathy DOID:0060053 12 0.606
nervous system disease DOID:863 431 0.606
neuropathy DOID:870 52 0.606
immune system disease DOID:2914 155 0.020
hematopoietic system disease DOID:74 100 0.011
physical disorder DOID:0080015 41 0.001