Homo sapiens

0 known processes

FBXW2

F-box and WD repeat domain containing 2

(Aliases: FBW2,Md6,MGC117371,Fwd2)

FBXW2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
scf dependent proteasomal ubiquitin dependent protein catabolic process GO:0031146 15 0.999
modification dependent protein catabolic process GO:0019941 209 0.785
ubiquitin dependent protein catabolic process GO:0006511 206 0.782
modification dependent macromolecule catabolic process GO:0043632 212 0.774
cellular protein catabolic process GO:0044257 261 0.746
cellular macromolecule catabolic process GO:0044265 380 0.720
protein ubiquitination GO:0016567 314 0.686
proteasomal protein catabolic process GO:0010498 176 0.682
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.610
neuron remodeling GO:0016322 2 0.531
protein modification by small protein conjugation GO:0032446 342 0.473
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.438
protein catabolic process GO:0030163 325 0.429
protein polyubiquitination GO:0000209 110 0.261
determination of adult lifespan GO:0008340 2 0.253
negative regulation of glial cell proliferation GO:0060253 2 0.234
multicellular organismal aging GO:0010259 3 0.197
regulation of tor signaling GO:0032006 30 0.179
positive regulation of nf kappab import into nucleus GO:0042346 13 0.150
female gamete generation GO:0007292 2 0.142
oogenesis GO:0048477 2 0.124
mitotic cell cycle GO:0000278 326 0.104
positive regulation of cell death GO:0010942 263 0.103
protein neddylation GO:0045116 7 0.101
response to nitrogen compound GO:1901698 184 0.100
vesicle mediated transport GO:0016192 371 0.098
release of cytoplasmic sequestered nf kappab GO:0008588 4 0.092
mitotic cell cycle process GO:1903047 286 0.089
positive regulation of protein catabolic process GO:0045732 75 0.085
maintenance of location GO:0051235 112 0.079
segmentation GO:0035282 4 0.079
regulation of protein stability GO:0031647 87 0.079
regulation of centrosome cycle GO:0046605 15 0.077
response to hormone GO:0009725 175 0.076
positive regulation of programmed cell death GO:0043068 249 0.075
nuclear division GO:0000280 128 0.072
cellular amino acid metabolic process GO:0006520 116 0.071
cellular amine metabolic process GO:0044106 41 0.071
positive regulation of cellular catabolic process GO:0031331 284 0.066
regulation of protein ubiquitination GO:0031396 95 0.065
microtubule based process GO:0007017 210 0.064
cell projection organization GO:0030030 252 0.063
regulation of glial cell proliferation GO:0060251 4 0.062
positive regulation of protein ubiquitination GO:0031398 53 0.061
negative regulation of developmental process GO:0051093 247 0.061
positive regulation of protein modification by small protein conjugation or removal GO:1903322 61 0.060
regulation of cellular component biogenesis GO:0044087 281 0.059
single organism cellular localization GO:1902580 332 0.058
locomotory behavior GO:0007626 1 0.058
positive regulation of catabolic process GO:0009896 310 0.058
cellular response to peptide GO:1901653 59 0.054
positive regulation of apoptotic process GO:0043065 246 0.053
regulation of transferase activity GO:0051338 355 0.053
regulation of microtubule cytoskeleton organization GO:0070507 61 0.053
amine metabolic process GO:0009308 44 0.052
post embryonic development GO:0009791 2 0.052
cellular macromolecular complex assembly GO:0034622 324 0.051
negative regulation of multicellular organismal process GO:0051241 317 0.051
circadian behavior GO:0048512 2 0.051
metal ion transport GO:0030001 272 0.051
regulation of protein catabolic process GO:0042176 155 0.049
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 37 0.049
regulation of cell cycle process GO:0010564 266 0.048
oocyte differentiation GO:0009994 2 0.048
microtubule cytoskeleton organization GO:0000226 176 0.047
cation homeostasis GO:0055080 189 0.047
cellular response to nitrogen compound GO:1901699 144 0.047
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.046
regulation of cellular amino acid metabolic process GO:0006521 6 0.045
growth GO:0040007 202 0.045
negative regulation of cellular component organization GO:0051129 235 0.045
enzyme linked receptor protein signaling pathway GO:0007167 303 0.045
cell type specific apoptotic process GO:0097285 125 0.044
negative regulation of tor signaling GO:0032007 11 0.044
immune system development GO:0002520 195 0.043
regulation of cytoskeleton organization GO:0051493 177 0.043
associative learning GO:0008306 1 0.042
cellular ketone metabolic process GO:0042180 80 0.042
regulation of cellular ketone metabolic process GO:0010565 50 0.042
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.041
vasculature development GO:0001944 181 0.041
histone modification GO:0016570 251 0.040
ion homeostasis GO:0050801 230 0.039
endocytosis GO:0006897 159 0.039
lipid biosynthetic process GO:0008610 177 0.039
nervous system development GO:0007399 293 0.039
regulation of microtubule based process GO:0032886 74 0.038
negative regulation of cell proliferation GO:0008285 228 0.038
positive regulation of cellular amine metabolic process GO:0033240 7 0.038
response to organonitrogen compound GO:0010243 156 0.038
receptor mediated endocytosis GO:0006898 84 0.037
cellular lipid metabolic process GO:0044255 303 0.037
cell cycle g1 s phase transition GO:0044843 80 0.036
cellular response to endogenous stimulus GO:0071495 336 0.036
epithelial tube branching involved in lung morphogenesis GO:0060441 4 0.036
negative regulation of wnt signaling pathway GO:0030178 69 0.035
cell development GO:0048468 328 0.035
oocyte development GO:0048599 1 0.035
response to peptide GO:1901652 65 0.035
morphogenesis of embryonic epithelium GO:0016331 4 0.035
g1 s transition of mitotic cell cycle GO:0000082 78 0.034
regulation of proteolysis GO:0030162 293 0.034
posttranscriptional regulation of gene expression GO:0010608 213 0.034
organelle fission GO:0048285 149 0.034
negative regulation of gliogenesis GO:0014014 3 0.033
cell cycle phase transition GO:0044770 173 0.033
positive regulation of hydrolase activity GO:0051345 331 0.033
response to metal ion GO:0010038 84 0.033
mitotic nuclear division GO:0007067 119 0.033
positive regulation of proteolysis GO:0045862 142 0.032
histone ubiquitination GO:0016574 31 0.032
blood vessel morphogenesis GO:0048514 162 0.032
cytoplasmic transport GO:0016482 379 0.032
apoptotic signaling pathway GO:0097190 268 0.032
cellular homeostasis GO:0019725 196 0.032
developmental programmed cell death GO:0010623 3 0.031
regulation of cellular amine metabolic process GO:0033238 11 0.031
aging GO:0007568 66 0.031
tor signaling GO:0031929 39 0.030
cellular cation homeostasis GO:0030003 163 0.030
cellular protein complex assembly GO:0043623 188 0.030
positive regulation of transport GO:0051050 336 0.030
positive regulation of transferase activity GO:0051347 227 0.030
generation of neurons GO:0048699 152 0.030
cellular chemical homeostasis GO:0055082 180 0.030
neurogenesis GO:0022008 169 0.029
cation transport GO:0006812 331 0.029
inorganic ion transmembrane transport GO:0098660 231 0.029
regulation of cell cycle GO:0051726 393 0.029
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.029
smoothened signaling pathway GO:0007224 14 0.028
neural tube formation GO:0001841 3 0.028
regulation of protein kinase activity GO:0045859 289 0.028
anterior posterior axis specification GO:0009948 2 0.028
negative regulation of cell cycle process GO:0010948 121 0.028
response to inorganic substance GO:0010035 127 0.028
organophosphate catabolic process GO:0046434 430 0.028
defense response GO:0006952 315 0.027
cellular response to organonitrogen compound GO:0071417 124 0.027
nitrogen compound transport GO:0071705 191 0.027
regulation of organelle assembly GO:1902115 40 0.027
regulation of protein localization GO:0032880 296 0.026
protein processing GO:0016485 226 0.026
histone monoubiquitination GO:0010390 20 0.026
angiogenesis GO:0001525 147 0.026
regulation of cell differentiation GO:0045595 393 0.026
dna conformation change GO:0071103 113 0.026
cellular response to oxygen containing compound GO:1901701 276 0.026
regulation of mapk cascade GO:0043408 262 0.025
chromosome segregation GO:0007059 114 0.025
negative regulation of apoptotic process GO:0043066 316 0.025
negative regulation of cell death GO:0060548 345 0.025
neuromuscular junction development GO:0007528 3 0.025
cell adhesion GO:0007155 325 0.025
regulation of kinase activity GO:0043549 314 0.025
regulation of dna metabolic process GO:0051052 153 0.025
defense response to bacterium GO:0042742 63 0.025
centrosome duplication GO:0051298 28 0.025
i kappab kinase nf kappab signaling GO:0007249 166 0.025
establishment of nucleus localization GO:0040023 1 0.024
cellular response to insulin stimulus GO:0032869 41 0.024
purine nucleoside triphosphate metabolic process GO:0009144 412 0.024
epithelial cell proliferation GO:0050673 128 0.024
response to oxygen containing compound GO:1901700 369 0.024
protein stabilization GO:0050821 64 0.024
cellular response to dna damage stimulus GO:0006974 379 0.024
positive regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902177 4 0.024
signal transduction by phosphorylation GO:0023014 297 0.024
immune response GO:0006955 307 0.024
cell growth GO:0016049 160 0.023
cell part morphogenesis GO:0032990 137 0.023
response to biotic stimulus GO:0009607 276 0.023
ion transmembrane transport GO:0034220 338 0.023
negative regulation of smoothened signaling pathway GO:0045879 3 0.023
neuron differentiation GO:0030182 138 0.023
developmental maturation GO:0021700 28 0.023
transmembrane transport GO:0055085 399 0.023
cell morphogenesis GO:0000902 296 0.023
g2 m transition of mitotic cell cycle GO:0000086 41 0.023
reproductive process GO:0022414 106 0.023
positive regulation of protein transport GO:0051222 135 0.023
response to peptide hormone GO:0043434 61 0.023
positive regulation of intrinsic apoptotic signaling pathway GO:2001244 28 0.022
covalent chromatin modification GO:0016569 254 0.022
regulation of meiotic cell cycle GO:0051445 4 0.022
regulation of cell development GO:0060284 161 0.022
monovalent inorganic cation homeostasis GO:0055067 37 0.022
negative regulation of multi organism process GO:0043901 92 0.021
cellular response to hormone stimulus GO:0032870 125 0.021
glycosyl compound catabolic process GO:1901658 413 0.021
regulation of neurogenesis GO:0050767 82 0.021
chemical homeostasis GO:0048878 306 0.021
regulation of mitotic cell cycle GO:0007346 189 0.021
negative regulation of catalytic activity GO:0043086 335 0.021
peptide transport GO:0015833 74 0.021
regulation of multi organism process GO:0043900 157 0.021
mitotic cell cycle phase transition GO:0044772 162 0.021
defense response to other organism GO:0098542 129 0.021
regulation of cellular protein catabolic process GO:1903362 96 0.021
chromatin organization GO:0006325 351 0.021
metal ion homeostasis GO:0055065 169 0.021
regulation of cellular component size GO:0032535 82 0.020
embryo development GO:0009790 123 0.020
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.020
regulation of mitotic cell cycle phase transition GO:1901990 118 0.020
dna replication GO:0006260 116 0.020
actin filament based process GO:0030029 224 0.020
biological adhesion GO:0022610 331 0.019
positive regulation of cellular component organization GO:0051130 376 0.019
hematopoietic or lymphoid organ development GO:0048534 186 0.019
negative regulation of protein metabolic process GO:0051248 391 0.019
glial cell migration GO:0008347 4 0.019
maintenance of location in cell GO:0051651 62 0.019
negative regulation of programmed cell death GO:0043069 321 0.019
centrosome organization GO:0051297 58 0.019
response to radiation GO:0009314 151 0.019
positive regulation of apoptotic signaling pathway GO:2001235 70 0.019
protein localization to organelle GO:0033365 280 0.019
negative regulation of epithelial cell proliferation GO:0050680 48 0.019
regulation of anatomical structure morphogenesis GO:0022603 286 0.018
intracellular protein transport GO:0006886 270 0.018
rna interference GO:0016246 4 0.018
transition metal ion homeostasis GO:0055076 31 0.018
nf kappab import into nucleus GO:0042348 22 0.018
regulation of neural precursor cell proliferation GO:2000177 4 0.018
lipid localization GO:0010876 106 0.018
meiotic chromosome segregation GO:0045132 4 0.018
nucleus localization GO:0051647 1 0.018
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.018
regulation of cell cycle phase transition GO:1901987 126 0.018
system process GO:0003008 349 0.018
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.017
hindbrain development GO:0030902 3 0.017
regulation of cellular ph GO:0030641 17 0.017
response to virus GO:0009615 126 0.017
blood vessel development GO:0001568 172 0.017
small gtpase mediated signal transduction GO:0007264 78 0.017
neural tube patterning GO:0021532 2 0.017
tripartite regional subdivision GO:0007351 2 0.017
protein k48 linked ubiquitination GO:0070936 38 0.016
amide transport GO:0042886 76 0.016
blastoderm segmentation GO:0007350 2 0.016
regulation of meiosis GO:0040020 3 0.016
neuron projection development GO:0031175 106 0.016
acylglycerol biosynthetic process GO:0046463 11 0.016
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.016
negative regulation of cell cycle GO:0045786 193 0.016
positive regulation of protein kinase activity GO:0045860 190 0.016
cerebral cortex radially oriented cell migration GO:0021799 1 0.016
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.016
response to external biotic stimulus GO:0043207 261 0.016
memory GO:0007613 3 0.016
regulation of proteasomal protein catabolic process GO:0061136 87 0.016
response to insulin GO:0032868 45 0.016
endomembrane system organization GO:0010256 196 0.016
peptidyl tyrosine modification GO:0018212 170 0.016
cell projection morphogenesis GO:0048858 129 0.016
cellular response to peptide hormone stimulus GO:0071375 56 0.016
regulation of ion transport GO:0043269 189 0.016
purine nucleoside triphosphate catabolic process GO:0009146 392 0.015
regulation of epithelial cell proliferation GO:0050678 113 0.015
regulation of cytoplasmic transport GO:1903649 149 0.015
nucleoside triphosphate catabolic process GO:0009143 394 0.015
dna repair GO:0006281 198 0.015
negative regulation of growth GO:0045926 97 0.015
meiosis i GO:0007127 4 0.015
sleep GO:0030431 2 0.015
negative regulation of dna replication GO:0008156 29 0.015
cardiovascular system development GO:0072358 262 0.015
regulation of cellular response to stress GO:0080135 244 0.015
response to organic cyclic compound GO:0014070 204 0.015
cation transmembrane transport GO:0098655 238 0.015
regulation of insulin receptor signaling pathway GO:0046626 13 0.015
gtp metabolic process GO:0046039 239 0.015
er associated ubiquitin dependent protein catabolic process GO:0030433 31 0.015
nerve development GO:0021675 4 0.015
neuron death in response to oxidative stress GO:0036475 9 0.015
wnt signaling pathway GO:0016055 156 0.015
neurological system process GO:0050877 163 0.015
guanosine containing compound metabolic process GO:1901068 244 0.015
rna processing GO:0006396 255 0.015
glycerolipid metabolic process GO:0046486 107 0.014
embryonic epithelial tube formation GO:0001838 4 0.014
mapk cascade GO:0000165 288 0.014
cellular response to oxidative stress GO:0034599 85 0.014
intrinsic apoptotic signaling pathway GO:0097193 127 0.014
cellular response to organic cyclic compound GO:0071407 127 0.014
regulation of peptidase activity GO:0052547 180 0.014
response to abiotic stimulus GO:0009628 336 0.014
negative regulation of phosphate metabolic process GO:0045936 267 0.014
protein targeting GO:0006605 187 0.014
positive regulation of phosphorylation GO:0042327 394 0.014
developmental process involved in reproduction GO:0003006 66 0.014
anterior posterior axis specification embryo GO:0008595 2 0.014
embryonic camera type eye development GO:0031076 2 0.014
protein localization to nucleus GO:0034504 136 0.014
positive regulation of ubiquitin protein transferase activity GO:0051443 18 0.014
sex differentiation GO:0007548 45 0.014
positive regulation of cell proliferation GO:0008284 301 0.014
negative regulation of cell differentiation GO:0045596 171 0.014
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.014
gtp catabolic process GO:0006184 237 0.014
mammary gland morphogenesis GO:0060443 2 0.014
circulatory system development GO:0072359 262 0.014
positive regulation of nucleotide metabolic process GO:0045981 230 0.014
cerebral cortex cell migration GO:0021795 3 0.013
negative regulation of dna metabolic process GO:0051053 57 0.013
negative regulation of cellular protein metabolic process GO:0032269 353 0.013
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.013
positive regulation of epidermal growth factor activated receptor activity GO:0045741 8 0.013
negative regulation of neural precursor cell proliferation GO:2000178 1 0.013
spermatid differentiation GO:0048515 4 0.013
negative regulation of immune system process GO:0002683 136 0.013
guanosine containing compound catabolic process GO:1901069 239 0.013
negative regulation of neurogenesis GO:0050768 26 0.013
regulation of neuron death GO:1901214 56 0.013
regulation of purine nucleotide metabolic process GO:1900542 264 0.013
regulation of cell division GO:0051302 116 0.013
actin filament organization GO:0007015 128 0.013
ribonucleotide catabolic process GO:0009261 405 0.013
regulation of mitosis GO:0007088 63 0.013
response to sterol depletion GO:0006991 4 0.013
dna packaging GO:0006323 77 0.013
positive regulation of kinase activity GO:0033674 204 0.013
ameboidal type cell migration GO:0001667 135 0.013
reproduction GO:0000003 63 0.013
establishment of protein localization to organelle GO:0072594 172 0.013
neuron development GO:0048666 113 0.013
compound eye development GO:0048749 1 0.013
positive regulation of cellular component biogenesis GO:0044089 158 0.013
regulation of gene expression epigenetic GO:0040029 73 0.013
cellular ion homeostasis GO:0006873 168 0.012
regulation of nervous system development GO:0051960 88 0.012
purine nucleotide catabolic process GO:0006195 405 0.012
centrosome cycle GO:0007098 32 0.012
regulation of purine nucleotide catabolic process GO:0033121 205 0.012
secretion GO:0046903 254 0.012
regulation of nucleoside metabolic process GO:0009118 209 0.012
regulation of endopeptidase activity GO:0052548 170 0.012
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.012
ribonucleoside triphosphate metabolic process GO:0009199 412 0.012
purine ribonucleotide catabolic process GO:0009154 404 0.012
positive regulation of synaptic transmission GO:0050806 4 0.012
nucleoside triphosphate metabolic process GO:0009141 422 0.012
cellular metal ion homeostasis GO:0006875 146 0.012
neuron projection morphogenesis GO:0048812 50 0.012
nucleoside catabolic process GO:0009164 408 0.012
protein import GO:0017038 130 0.012
organelle assembly GO:0070925 176 0.012
negative regulation of nervous system development GO:0051961 28 0.012
negative regulation of cell growth GO:0030308 83 0.012
adult locomotory behavior GO:0008344 1 0.012
negative regulation of transport GO:0051051 176 0.012
regulation of nucleotide metabolic process GO:0006140 269 0.012
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.012
ribonucleoprotein complex biogenesis GO:0022613 116 0.012
lipid metabolic process GO:0006629 381 0.012
divalent inorganic cation transport GO:0072511 158 0.012
inorganic cation transmembrane transport GO:0098662 194 0.012
innate immune response GO:0045087 178 0.012
regulation of cell growth GO:0001558 135 0.012
nucleoside phosphate catabolic process GO:1901292 412 0.012
dna damage checkpoint GO:0000077 68 0.012
dephosphorylation GO:0016311 209 0.011
reproductive structure development GO:0048608 55 0.011
immune effector process GO:0002252 159 0.011
negative regulation of phosphorus metabolic process GO:0010563 267 0.011
regulation of circadian sleep wake cycle GO:0042749 2 0.011
ncrna metabolic process GO:0034660 108 0.011
regulation of nuclear division GO:0051783 65 0.011
regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:2000058 7 0.011
nucleotide catabolic process GO:0009166 408 0.011
jnk cascade GO:0007254 80 0.011
protein acylation GO:0043543 138 0.011
centromere complex assembly GO:0034508 10 0.011
detection of stimulus GO:0051606 85 0.011
regulation of cysteine type endopeptidase activity GO:2000116 127 0.011
negative regulation of hydrolase activity GO:0051346 182 0.011
gliogenesis GO:0042063 21 0.011
maintenance of protein location in cell GO:0032507 56 0.011
negative regulation of cytoplasmic transport GO:1903650 46 0.011
protein k63 linked ubiquitination GO:0070534 31 0.011
positive regulation of circadian rhythm GO:0042753 1 0.011
regulation of intracellular transport GO:0032386 195 0.011
organonitrogen compound biosynthetic process GO:1901566 200 0.011
blastocyst development GO:0001824 3 0.011
regulation of cell projection organization GO:0031344 107 0.011
oxidation reduction process GO:0055114 396 0.011
nuclear import GO:0051170 106 0.011
kinetochore organization GO:0051383 8 0.011
regulation of erk1 and erk2 cascade GO:0070372 99 0.011
regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902175 16 0.010
positive regulation of nucleotide catabolic process GO:0030813 185 0.010
cardiac muscle cell contraction GO:0086003 4 0.010
regulation of protein complex assembly GO:0043254 147 0.010
ribonucleoside catabolic process GO:0042454 406 0.010
hepatocyte proliferation GO:0072574 1 0.010
iron ion homeostasis GO:0055072 15 0.010
negative regulation of transcription factor import into nucleus GO:0042992 17 0.010
chromatin modification GO:0016568 298 0.010
negative regulation of cellular amine metabolic process GO:0033239 3 0.010
positive regulation of cell cycle GO:0045787 140 0.010
sequestering of metal ion GO:0051238 24 0.010
regulation of protein tyrosine kinase activity GO:0061097 36 0.010
negative regulation of protein processing GO:0010955 142 0.010
regulation of cytokine production GO:0001817 232 0.010
neuron death GO:0070997 65 0.010
nuclear migration GO:0007097 1 0.010
tissue morphogenesis GO:0048729 96 0.010
regulation of centrosome duplication GO:0010824 14 0.010

FBXW2 disease predictions

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 186 0.027
nervous system disease DOID:863 431 0.027
neurodegenerative disease DOID:1289 102 0.023
musculoskeletal system disease DOID:17 223 0.015
sensory system disease DOID:0050155 203 0.014
muscular disease DOID:0080000 114 0.011
myopathy DOID:423 104 0.011
muscle tissue disease DOID:66 113 0.011