Homo sapiens

196 known processes

FIS1

fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)

(Aliases: TTC11)

FIS1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
positive regulation of mitochondrial calcium ion concentration GO:0051561 8 0.992
mitochondrial calcium ion homeostasis GO:0051560 11 0.989
calcium mediated signaling using intracellular calcium source GO:0035584 7 0.705
negative regulation of endoplasmic reticulum calcium ion concentration GO:0032471 6 0.576
intracellular protein transport GO:0006886 270 0.552
positive regulation of protein targeting to membrane GO:0090314 8 0.537
post embryonic development GO:0009791 2 0.507
protein localization to organelle GO:0033365 280 0.454
intrinsic apoptotic signaling pathway GO:0097193 127 0.369
mitochondrion organization GO:0007005 156 0.368
positive regulation of hydrolase activity GO:0051345 331 0.326
regulation of mitochondrial fission GO:0090140 8 0.287
positive regulation of transport GO:0051050 336 0.235
cellular chemical homeostasis GO:0055082 180 0.231
reactive oxygen species metabolic process GO:0072593 75 0.230
protein targeting GO:0006605 187 0.230
cellular cation homeostasis GO:0030003 163 0.220
cellular divalent inorganic cation homeostasis GO:0072503 128 0.203
cytoplasmic transport GO:0016482 379 0.200
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.166
positive regulation of apoptotic process GO:0043065 246 0.157
positive regulation of cell death GO:0010942 263 0.151
cellular metal ion homeostasis GO:0006875 146 0.146
positive regulation of mitochondrial fission GO:0090141 7 0.141
cytosolic calcium ion homeostasis GO:0051480 89 0.133
ion homeostasis GO:0050801 230 0.133
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.129
cellular calcium ion homeostasis GO:0006874 117 0.120
nadph oxidation GO:0070995 3 0.119
positive regulation of programmed cell death GO:0043068 249 0.118
divalent inorganic cation homeostasis GO:0072507 136 0.117
negative regulation of programmed cell death GO:0043069 321 0.116
positive regulation of organelle organization GO:0010638 195 0.114
osteoblast differentiation GO:0001649 92 0.112
calcium ion homeostasis GO:0055074 122 0.109
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.108
positive regulation of cytosolic calcium ion concentration GO:0007204 82 0.102
cellular ketone metabolic process GO:0042180 80 0.101
immune response GO:0006955 307 0.100
establishment of protein localization to organelle GO:0072594 172 0.099
ossification GO:0001503 121 0.090
metal ion homeostasis GO:0055065 169 0.088
cation homeostasis GO:0055080 189 0.083
single organism membrane organization GO:0044802 268 0.080
divalent inorganic cation transport GO:0072511 158 0.079
apoptotic signaling pathway GO:0097190 268 0.079
positive regulation of peptidase activity GO:0010952 88 0.074
regulation of endopeptidase activity GO:0052548 170 0.073
negative regulation of protein metabolic process GO:0051248 391 0.068
vesicle mediated transport GO:0016192 371 0.065
cofactor metabolic process GO:0051186 87 0.062
regulation of cysteine type endopeptidase activity GO:2000116 127 0.061
positive regulation of secretion by cell GO:1903532 108 0.061
cellular macromolecule catabolic process GO:0044265 380 0.058
modification dependent protein catabolic process GO:0019941 209 0.058
positive regulation of intrinsic apoptotic signaling pathway GO:2001244 28 0.058
cardiac muscle contraction GO:0060048 34 0.056
cellular protein catabolic process GO:0044257 261 0.056
response to inorganic substance GO:0010035 127 0.056
regulation of secretion by cell GO:1903530 177 0.053
secretion by cell GO:0032940 226 0.053
regulation of response to external stimulus GO:0032101 222 0.052
positive regulation of cellular component organization GO:0051130 376 0.051
cellular ion homeostasis GO:0006873 168 0.050
membrane organization GO:0061024 292 0.048
positive regulation of mitochondrion organization GO:0010822 30 0.048
regulation of proteolysis GO:0030162 293 0.048
regulation of cellular component biogenesis GO:0044087 281 0.046
guanosine containing compound catabolic process GO:1901069 239 0.044
protein ubiquitination GO:0016567 314 0.044
regulation of apoptotic signaling pathway GO:2001233 175 0.044
positive regulation of endopeptidase activity GO:0010950 84 0.044
secretion GO:0046903 254 0.043
oogenesis GO:0048477 2 0.041
protein modification by small protein conjugation GO:0032446 342 0.040
cellular macromolecular complex assembly GO:0034622 324 0.039
positive regulation of apoptotic signaling pathway GO:2001235 70 0.038
protein catabolic process GO:0030163 325 0.038
positive regulation of secretion GO:0051047 116 0.036
regulation of protein localization GO:0032880 296 0.036
viral process GO:0016032 146 0.036
gtp catabolic process GO:0006184 237 0.035
negative regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043154 46 0.034
regulation of protein targeting GO:1903533 91 0.033
organophosphate catabolic process GO:0046434 430 0.033
second messenger mediated signaling GO:0019932 78 0.033
protein localization to membrane GO:0072657 160 0.033
regulation of intracellular transport GO:0032386 195 0.033
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.033
nucleotide catabolic process GO:0009166 408 0.033
inorganic cation transmembrane transport GO:0098662 194 0.032
regulation of intracellular protein transport GO:0033157 123 0.032
cation transport GO:0006812 331 0.032
single organism cellular localization GO:1902580 332 0.031
modification dependent macromolecule catabolic process GO:0043632 212 0.031
coenzyme metabolic process GO:0006732 65 0.031
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.031
purine nucleoside triphosphate metabolic process GO:0009144 412 0.031
mitochondrial fission GO:0000266 14 0.030
regulation of proteasomal protein catabolic process GO:0061136 87 0.030
protein targeting to membrane GO:0006612 42 0.029
regulation of cellular component size GO:0032535 82 0.029
anatomical structure homeostasis GO:0060249 100 0.028
negative regulation of growth GO:0045926 97 0.028
protein acetylation GO:0006473 116 0.028
regulation of anatomical structure size GO:0090066 101 0.028
cellular amino acid metabolic process GO:0006520 116 0.027
nucleoside phosphate catabolic process GO:1901292 412 0.027
establishment or maintenance of bipolar cell polarity GO:0061245 2 0.027
determination of adult lifespan GO:0008340 2 0.027
cellular response to oxygen containing compound GO:1901701 276 0.026
positive regulation of catabolic process GO:0009896 310 0.026
reactive nitrogen species metabolic process GO:2001057 3 0.026
proteasomal protein catabolic process GO:0010498 176 0.025
regulation of protein transport GO:0051223 213 0.025
defense response to bacterium GO:0042742 63 0.025
negative regulation of cellular protein metabolic process GO:0032269 353 0.025
peptidyl lysine modification GO:0018205 144 0.025
negative regulation of protein modification process GO:0031400 200 0.025
response to oxygen containing compound GO:1901700 369 0.025
regulation of purine nucleotide metabolic process GO:1900542 264 0.025
protein localization to endoplasmic reticulum GO:0070972 19 0.024
nucleoside catabolic process GO:0009164 408 0.024
defense response GO:0006952 315 0.024
regulation of gtp catabolic process GO:0033124 180 0.023
regulation of protein catabolic process GO:0042176 155 0.023
purine ribonucleotide catabolic process GO:0009154 404 0.022
response to organic cyclic compound GO:0014070 204 0.022
innate immune response GO:0045087 178 0.021
protein import GO:0017038 130 0.021
chemical homeostasis GO:0048878 306 0.021
positive regulation of protein transport GO:0051222 135 0.021
regulation of multi organism process GO:0043900 157 0.021
purine ribonucleoside catabolic process GO:0046130 398 0.021
establishment of viral latency GO:0019043 1 0.020
ras protein signal transduction GO:0007265 73 0.020
regulation of peptidase activity GO:0052547 180 0.020
negative regulation of catalytic activity GO:0043086 335 0.020
regulation of anatomical structure morphogenesis GO:0022603 286 0.020
ubiquitin dependent protein catabolic process GO:0006511 206 0.020
transmembrane transport GO:0055085 399 0.020
collagen metabolic process GO:0032963 28 0.020
organelle fission GO:0048285 149 0.020
female gamete generation GO:0007292 2 0.019
gtp metabolic process GO:0046039 239 0.019
sulfur compound metabolic process GO:0006790 101 0.019
positive regulation of cellular component movement GO:0051272 181 0.019
negative regulation of protein processing GO:0010955 142 0.019
regulation of gtpase activity GO:0043087 180 0.019
negative regulation of apoptotic process GO:0043066 316 0.019
endocytosis GO:0006897 159 0.019
endoplasmic reticulum calcium ion homeostasis GO:0032469 9 0.018
regulation of mitochondrion organization GO:0010821 54 0.018
negative regulation of protein maturation GO:1903318 142 0.018
regulation of exocytosis GO:0017157 46 0.018
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 40 0.018
purine ribonucleoside metabolic process GO:0046128 437 0.018
hydrogen peroxide metabolic process GO:0042743 20 0.018
establishment of protein localization to mitochondrion GO:0072655 22 0.018
ribonucleotide catabolic process GO:0009261 405 0.018
regulation of cellular component movement GO:0051270 334 0.017
intracellular protein transmembrane import GO:0044743 23 0.017
cell growth GO:0016049 160 0.017
carbohydrate derivative biosynthetic process GO:1901137 207 0.017
regulation of nucleotide metabolic process GO:0006140 269 0.017
mitotic nuclear division GO:0007067 119 0.016
regulation of protein ubiquitination GO:0031396 95 0.016
protein processing GO:0016485 226 0.016
steroid metabolic process GO:0008202 94 0.016
regulation of secretion GO:0051046 194 0.016
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.016
regulation of defense response GO:0031347 154 0.016
metal ion transport GO:0030001 272 0.016
multicellular organismal aging GO:0010259 3 0.016
purine nucleoside catabolic process GO:0006152 398 0.016
posttranscriptional regulation of gene expression GO:0010608 213 0.016
regulation of cellular amine metabolic process GO:0033238 11 0.016
positive regulation of cellular amine metabolic process GO:0033240 7 0.016
reproductive process GO:0022414 106 0.015
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.015
positive regulation of immune system process GO:0002684 283 0.015
interspecies interaction between organisms GO:0044419 156 0.015
mitochondrial membrane organization GO:0007006 40 0.015
positive regulation of cellular catabolic process GO:0031331 284 0.015
reproductive structure development GO:0048608 55 0.015
purine nucleotide catabolic process GO:0006195 405 0.015
regulation of cellular amino acid metabolic process GO:0006521 6 0.015
golgi vesicle transport GO:0048193 80 0.015
nucleoside triphosphate metabolic process GO:0009141 422 0.015
regulation of innate immune response GO:0045088 97 0.015
positive regulation of protein phosphorylation GO:0001934 313 0.015
establishment of protein localization to membrane GO:0090150 121 0.014
regulation of nucleotide catabolic process GO:0030811 205 0.014
negative regulation of cell proliferation GO:0008285 228 0.014
hemostasis GO:0007599 76 0.014
cellular response to extracellular stimulus GO:0031668 72 0.014
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.014
ribonucleoside catabolic process GO:0042454 406 0.014
myeloid cell differentiation GO:0030099 117 0.014
positive regulation of developmental process GO:0051094 314 0.014
ion transmembrane transport GO:0034220 338 0.014
mitotic cell cycle process GO:1903047 286 0.014
negative regulation of phosphorus metabolic process GO:0010563 267 0.014
actin filament based process GO:0030029 224 0.014
embryo development GO:0009790 123 0.014
negative regulation of cell cycle GO:0045786 193 0.014
cellular protein complex assembly GO:0043623 188 0.014
regulation of cell growth GO:0001558 135 0.014
positive regulation of phosphorylation GO:0042327 394 0.014
er to golgi vesicle mediated transport GO:0006888 19 0.014
positive regulation of protein catabolic process GO:0045732 75 0.013
regulation of cell motility GO:2000145 299 0.013
response to metal ion GO:0010038 84 0.013
negative regulation of proteolysis GO:0045861 132 0.013
protein localization to nucleus GO:0034504 136 0.013
protein deubiquitination GO:0016579 79 0.013
small gtpase mediated signal transduction GO:0007264 78 0.013
response to other organism GO:0051707 261 0.013
enzyme linked receptor protein signaling pathway GO:0007167 303 0.013
divalent metal ion transport GO:0070838 152 0.013
rna interference GO:0016246 4 0.013
negative regulation of hydrolase activity GO:0051346 182 0.013
negative regulation of protein ubiquitination GO:0031397 35 0.013
purine containing compound catabolic process GO:0072523 411 0.013
cellular response to cytokine stimulus GO:0071345 181 0.013
cell development GO:0048468 328 0.013
nucleoside phosphate biosynthetic process GO:1901293 109 0.013
glycosyl compound catabolic process GO:1901658 413 0.013
extrinsic apoptotic signaling pathway GO:0097191 119 0.013
regulation of immune response GO:0050776 201 0.013
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.012
cellular response to hydrogen peroxide GO:0070301 37 0.012
response to bacterium GO:0009617 144 0.012
negative regulation of protein modification by small protein conjugation or removal GO:1903321 41 0.012
developmental process involved in reproduction GO:0003006 66 0.012
negative regulation of intracellular signal transduction GO:1902532 183 0.012
defense response to other organism GO:0098542 129 0.012
positive regulation of locomotion GO:0040017 186 0.012
response to cytokine GO:0034097 232 0.012
positive regulation of protein complex assembly GO:0031334 86 0.012
biological adhesion GO:0022610 331 0.012
apoptotic mitochondrial changes GO:0008637 57 0.012
ribonucleoside triphosphate metabolic process GO:0009199 412 0.012
response to nitrogen compound GO:1901698 184 0.012
regulation of protein processing GO:0070613 150 0.012
regulation of binding GO:0051098 111 0.012
regulation of oxidoreductase activity GO:0051341 43 0.011
multi organism cellular process GO:0044764 156 0.011
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.011
sex differentiation GO:0007548 45 0.011
purine nucleoside triphosphate catabolic process GO:0009146 392 0.011
single organism reproductive process GO:0044702 98 0.011
nucleocytoplasmic transport GO:0006913 176 0.011
ncrna metabolic process GO:0034660 108 0.011
positive regulation of intracellular transport GO:0032388 104 0.011
positive regulation of protein kinase activity GO:0045860 190 0.011
viral life cycle GO:0019058 132 0.011
calcium ion transport GO:0006816 147 0.011
regulation of reactive oxygen species metabolic process GO:2000377 41 0.011
mapk cascade GO:0000165 288 0.011
amine metabolic process GO:0009308 44 0.011
negative regulation of cell death GO:0060548 345 0.011
microtubule cytoskeleton organization GO:0000226 176 0.011
growth GO:0040007 202 0.011
peroxisome fission GO:0016559 10 0.011
regulation of ion transport GO:0043269 189 0.010
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.010
autophagy GO:0006914 88 0.010
organic hydroxy compound metabolic process GO:1901615 147 0.010
response to lipid GO:0033993 206 0.010
cellular response to nutrient levels GO:0031669 69 0.010
response to reactive oxygen species GO:0000302 61 0.010
glutathione metabolic process GO:0006749 20 0.010
regulation of purine nucleotide catabolic process GO:0033121 205 0.010
positive regulation of nucleotide metabolic process GO:0045981 230 0.010

FIS1 disease predictions

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 167 0.044
disease of cellular proliferation DOID:14566 174 0.044
organ system cancer DOID:0050686 164 0.044
endocrine gland cancer DOID:170 26 0.020