|
|
regulation of cyclase activity
|
GO:0031279 |
19 |
1.000
|
Fly |
|
|
camp biosynthetic process
|
GO:0006171 |
47 |
1.000
|
Fly |
|
|
adenylate cyclase modulating g protein coupled receptor signaling pathway
|
GO:0007188 |
43 |
0.999
|
Human |
|
|
regulation of camp metabolic process
|
GO:0030814 |
52 |
0.999
|
Fly |
|
|
regulation of adenylate cyclase activity
|
GO:0045761 |
17 |
0.999
|
Fly |
|
|
negative regulation of amine transport
|
GO:0051953 |
1 |
0.999
|
|
|
|
camp metabolic process
|
GO:0046058 |
61 |
0.996
|
Fly |
|
|
cyclic nucleotide biosynthetic process
|
GO:0009190 |
61 |
0.995
|
Fly |
|
|
cyclic nucleotide metabolic process
|
GO:0009187 |
82 |
0.994
|
Fly |
|
|
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger
|
GO:0007187 |
43 |
0.993
|
Human |
|
|
regulation of cyclic nucleotide biosynthetic process
|
GO:0030802 |
49 |
0.991
|
Fly |
|
|
g protein coupled receptor signaling pathway
|
GO:0007186 |
207 |
0.988
|
|
|
|
purine ribonucleotide biosynthetic process
|
GO:0009152 |
79 |
0.987
|
Fly |
|
|
nucleoside phosphate biosynthetic process
|
GO:1901293 |
109 |
0.987
|
Fly |
|
|
regulation of cyclic nucleotide metabolic process
|
GO:0030799 |
63 |
0.980
|
Fly |
|
|
regulation of lyase activity
|
GO:0051339 |
23 |
0.978
|
Fly |
|
|
regulation of purine nucleotide biosynthetic process
|
GO:1900371 |
50 |
0.958
|
Fly |
|
|
amino acid transport
|
GO:0006865 |
28 |
0.956
|
|
|
|
nucleotide biosynthetic process
|
GO:0009165 |
109 |
0.953
|
Fly |
|
|
ribonucleotide biosynthetic process
|
GO:0009260 |
81 |
0.949
|
Fly |
|
|
purine nucleotide biosynthetic process
|
GO:0006164 |
84 |
0.948
|
Fly |
|
|
purine containing compound biosynthetic process
|
GO:0072522 |
88 |
0.942
|
Fly |
|
|
cell cell signaling
|
GO:0007267 |
155 |
0.937
|
Fly |
|
|
peptide secretion
|
GO:0002790 |
51 |
0.924
|
Fly |
|
|
cation transport
|
GO:0006812 |
331 |
0.923
|
|
|
|
regulation of hormone levels
|
GO:0010817 |
125 |
0.916
|
Fly |
|
|
hormone secretion
|
GO:0046879 |
65 |
0.912
|
Fly |
|
|
organic anion transport
|
GO:0015711 |
103 |
0.880
|
|
|
|
epinephrine transport
|
GO:0048241 |
1 |
0.876
|
|
|
|
regulation of epinephrine secretion
|
GO:0014060 |
1 |
0.876
|
|
|
|
carbohydrate derivative biosynthetic process
|
GO:1901137 |
207 |
0.851
|
Fly |
|
|
peptide transport
|
GO:0015833 |
74 |
0.817
|
Fly |
|
|
negative regulation of camp metabolic process
|
GO:0030815 |
9 |
0.817
|
Fly |
|
|
organophosphate biosynthetic process
|
GO:0090407 |
163 |
0.814
|
Fly |
|
|
regulation of secretion by cell
|
GO:1903530 |
177 |
0.808
|
Fly |
|
|
positive regulation of amine transport
|
GO:0051954 |
2 |
0.781
|
|
|
|
regulation of catecholamine secretion
|
GO:0050433 |
1 |
0.774
|
|
|
|
dopamine transport
|
GO:0015872 |
5 |
0.768
|
|
|
|
anion transport
|
GO:0006820 |
161 |
0.759
|
|
|
|
regulation of amine transport
|
GO:0051952 |
5 |
0.758
|
|
|
|
amide transport
|
GO:0042886 |
76 |
0.719
|
Fly |
|
|
regulation of ion transport
|
GO:0043269 |
189 |
0.699
|
|
|
|
regulation of purine nucleotide metabolic process
|
GO:1900542 |
264 |
0.694
|
Fly |
|
|
secretion
|
GO:0046903 |
254 |
0.692
|
Fly |
|
|
regulation of hormone secretion
|
GO:0046883 |
57 |
0.690
|
Fly |
|
|
negative regulation of lyase activity
|
GO:0051350 |
7 |
0.671
|
Fly |
|
|
peptide hormone secretion
|
GO:0030072 |
50 |
0.671
|
Fly |
|
|
negative regulation of nucleotide biosynthetic process
|
GO:0030809 |
11 |
0.670
|
Fly |
|
|
organic hydroxy compound transport
|
GO:0015850 |
63 |
0.652
|
|
|
|
regulation of nucleotide metabolic process
|
GO:0006140 |
269 |
0.643
|
Fly |
|
|
organic acid transport
|
GO:0015849 |
65 |
0.614
|
|
|
|
epinephrine secretion
|
GO:0048242 |
1 |
0.605
|
|
|
|
negative regulation of cyclic nucleotide biosynthetic process
|
GO:0030803 |
10 |
0.567
|
Fly |
|
|
acid secretion
|
GO:0046717 |
12 |
0.564
|
|
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
267 |
0.562
|
Fly |
|
|
hormone transport
|
GO:0009914 |
68 |
0.556
|
Fly |
|
|
negative regulation of hormone secretion
|
GO:0046888 |
15 |
0.548
|
Fly |
|
|
amine transport
|
GO:0015837 |
7 |
0.543
|
|
|
|
growth hormone secretion
|
GO:0030252 |
4 |
0.539
|
|
|
|
response to oxygen containing compound
|
GO:1901700 |
369 |
0.530
|
|
|
|
negative regulation of ion transport
|
GO:0043271 |
39 |
0.525
|
|
|
|
carboxylic acid transport
|
GO:0046942 |
63 |
0.504
|
|
|
|
regulation of synaptic plasticity
|
GO:0048167 |
3 |
0.492
|
|
|
|
negative regulation of secretion
|
GO:0051048 |
58 |
0.488
|
Fly |
|
|
negative regulation of secretion by cell
|
GO:1903531 |
52 |
0.487
|
Fly |
|
|
regulation of peptide hormone secretion
|
GO:0090276 |
41 |
0.477
|
Fly |
|
|
regulation of synaptic transmission
|
GO:0050804 |
11 |
0.475
|
Fly |
|
|
regulation of peptide transport
|
GO:0090087 |
62 |
0.470
|
Fly |
|
|
glycosyl compound catabolic process
|
GO:1901658 |
413 |
0.435
|
|
|
|
negative regulation of cyclase activity
|
GO:0031280 |
6 |
0.407
|
Fly |
|
|
positive regulation of peptide hormone secretion
|
GO:0090277 |
15 |
0.406
|
|
|
|
regulation of anion transport
|
GO:0044070 |
25 |
0.404
|
|
|
|
response to organonitrogen compound
|
GO:0010243 |
156 |
0.399
|
|
|
|
nucleoside catabolic process
|
GO:0009164 |
408 |
0.386
|
|
|
|
potassium ion transport
|
GO:0006813 |
62 |
0.384
|
|
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.378
|
Fly |
|
|
positive regulation of secretion
|
GO:0051047 |
116 |
0.377
|
|
|
|
nitrogen compound transport
|
GO:0071705 |
191 |
0.369
|
Fly |
|
|
purine nucleoside triphosphate metabolic process
|
GO:0009144 |
412 |
0.367
|
|
|
|
purine ribonucleotide catabolic process
|
GO:0009154 |
404 |
0.365
|
|
|
|
response to nitrogen compound
|
GO:1901698 |
184 |
0.349
|
|
|
|
regulation of neuronal synaptic plasticity
|
GO:0048168 |
1 |
0.344
|
|
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
411 |
0.336
|
|
|
|
organophosphate catabolic process
|
GO:0046434 |
430 |
0.334
|
|
|
|
neurotransmitter secretion
|
GO:0007269 |
4 |
0.333
|
Fly |
|
|
system process
|
GO:0003008 |
349 |
0.331
|
|
|
|
positive regulation of secretion by cell
|
GO:1903532 |
108 |
0.318
|
|
|
|
transmembrane transport
|
GO:0055085 |
399 |
0.315
|
|
|
|
synaptic transmission
|
GO:0007268 |
61 |
0.312
|
Fly |
|
|
ribonucleoside triphosphate catabolic process
|
GO:0009203 |
391 |
0.311
|
|
|
|
catecholamine transport
|
GO:0051937 |
6 |
0.308
|
|
|
|
monoamine transport
|
GO:0015844 |
10 |
0.304
|
|
|
|
osteoblast differentiation
|
GO:0001649 |
92 |
0.287
|
|
|
|
membrane organization
|
GO:0061024 |
292 |
0.281
|
Fly |
|
|
inorganic cation transmembrane transport
|
GO:0098662 |
194 |
0.268
|
|
|
|
single organism membrane organization
|
GO:0044802 |
268 |
0.267
|
Fly |
|
|
nucleoside triphosphate metabolic process
|
GO:0009141 |
422 |
0.263
|
|
|
|
response to alcohol
|
GO:0097305 |
64 |
0.253
|
|
|
|
ribonucleoside triphosphate metabolic process
|
GO:0009199 |
412 |
0.247
|
|
|
|
negative regulation of cell proliferation
|
GO:0008285 |
228 |
0.245
|
|
|
|
protein oligomerization
|
GO:0051259 |
173 |
0.244
|
|
|
|
locomotory behavior
|
GO:0007626 |
1 |
0.242
|
|
|
|
nucleotide catabolic process
|
GO:0009166 |
408 |
0.238
|
|
|
|
response to organic cyclic compound
|
GO:0014070 |
204 |
0.232
|
|
|
|
nucleoside triphosphate catabolic process
|
GO:0009143 |
394 |
0.230
|
|
|
|
ribonucleotide catabolic process
|
GO:0009261 |
405 |
0.229
|
|
|
|
nervous system development
|
GO:0007399 |
293 |
0.227
|
|
|
|
purine nucleotide catabolic process
|
GO:0006195 |
405 |
0.224
|
|
|
|
ossification
|
GO:0001503 |
121 |
0.223
|
|
|
|
negative regulation of purine nucleotide biosynthetic process
|
GO:1900372 |
11 |
0.220
|
Fly |
|
|
purine nucleoside catabolic process
|
GO:0006152 |
398 |
0.219
|
|
|
|
memory
|
GO:0007613 |
3 |
0.215
|
|
|
|
nucleoside phosphate catabolic process
|
GO:1901292 |
412 |
0.212
|
|
|
|
monovalent inorganic cation transport
|
GO:0015672 |
128 |
0.211
|
|
|
|
purine ribonucleoside metabolic process
|
GO:0046128 |
437 |
0.208
|
|
|
|
dicarboxylic acid transport
|
GO:0006835 |
13 |
0.207
|
|
|
|
positive regulation of cellular component organization
|
GO:0051130 |
376 |
0.206
|
|
|
|
ribonucleoside monophosphate catabolic process
|
GO:0009158 |
158 |
0.206
|
|
|
|
negative regulation of nucleotide metabolic process
|
GO:0045980 |
29 |
0.203
|
Fly |
|
|
purine nucleoside triphosphate catabolic process
|
GO:0009146 |
392 |
0.202
|
|
|
|
positive regulation of hormone secretion
|
GO:0046887 |
25 |
0.200
|
|
|
|
positive regulation of nucleotide metabolic process
|
GO:0045981 |
230 |
0.194
|
|
|
|
purine containing compound catabolic process
|
GO:0072523 |
411 |
0.193
|
|
|
|
synaptic vesicle transport
|
GO:0048489 |
5 |
0.191
|
Fly |
|
|
ion transmembrane transport
|
GO:0034220 |
338 |
0.188
|
|
|
|
response to nicotine
|
GO:0035094 |
12 |
0.183
|
|
|
|
regulation of cellular component biogenesis
|
GO:0044087 |
281 |
0.179
|
|
|
|
regulation of growth hormone secretion
|
GO:0060123 |
3 |
0.165
|
|
|
|
secretion by cell
|
GO:0032940 |
226 |
0.158
|
Fly |
|
|
plasma membrane organization
|
GO:0007009 |
115 |
0.155
|
|
|
|
neurological system process
|
GO:0050877 |
163 |
0.149
|
|
|
|
signal release
|
GO:0023061 |
70 |
0.146
|
Fly |
|
|
metal ion transport
|
GO:0030001 |
272 |
0.145
|
|
|
|
nucleoside monophosphate catabolic process
|
GO:0009125 |
159 |
0.142
|
|
|
|
negative regulation of cyclic nucleotide metabolic process
|
GO:0030800 |
10 |
0.141
|
Fly |
|
|
vesicle mediated transport
|
GO:0016192 |
371 |
0.137
|
Fly |
|
|
response to ethanol
|
GO:0045471 |
11 |
0.136
|
|
|
|
cation transmembrane transport
|
GO:0098655 |
238 |
0.129
|
|
|
|
ras protein signal transduction
|
GO:0007265 |
73 |
0.126
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
6 |
0.124
|
|
|
|
monocarboxylic acid transport
|
GO:0015718 |
32 |
0.123
|
|
|
|
neurogenesis
|
GO:0022008 |
169 |
0.112
|
|
|
|
regulation of ion transmembrane transport
|
GO:0034765 |
132 |
0.112
|
|
|
|
ribonucleoside monophosphate metabolic process
|
GO:0009161 |
187 |
0.111
|
|
|
|
cyclic purine nucleotide metabolic process
|
GO:0052652 |
60 |
0.110
|
Fly |
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.108
|
|
|
|
cytoplasmic transport
|
GO:0016482 |
379 |
0.108
|
|
|
|
regulation of growth
|
GO:0040008 |
165 |
0.108
|
|
|
|
neuron fate commitment
|
GO:0048663 |
2 |
0.106
|
|
|
|
regulation of cell development
|
GO:0060284 |
161 |
0.105
|
|
|
|
nucleoside monophosphate metabolic process
|
GO:0009123 |
191 |
0.105
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.104
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.100
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
11 |
0.100
|
|
|
|
receptor metabolic process
|
GO:0043112 |
81 |
0.099
|
|
|
|
regulation of transmembrane transport
|
GO:0034762 |
139 |
0.098
|
|
|
|
sensory perception
|
GO:0007600 |
103 |
0.096
|
|
|
|
growth
|
GO:0040007 |
202 |
0.095
|
|
|
|
inorganic ion transmembrane transport
|
GO:0098660 |
231 |
0.094
|
|
|
|
regulation of membrane potential
|
GO:0042391 |
95 |
0.093
|
|
|
|
small gtpase mediated signal transduction
|
GO:0007264 |
78 |
0.093
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
7 |
0.092
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
41 |
0.091
|
|
|
|
regulation of locomotion
|
GO:0040012 |
329 |
0.091
|
|
|
|
regulation of organic acid transport
|
GO:0032890 |
8 |
0.090
|
|
|
|
generation of neurons
|
GO:0048699 |
152 |
0.089
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.089
|
|
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.088
|
|
|
|
mapk cascade
|
GO:0000165 |
288 |
0.088
|
|
|
|
hindbrain development
|
GO:0030902 |
3 |
0.088
|
|
|
|
regulation of camp biosynthetic process
|
GO:0030817 |
45 |
0.087
|
Fly |
|
|
purine nucleoside monophosphate metabolic process
|
GO:0009126 |
186 |
0.087
|
|
|
|
cell development
|
GO:0048468 |
328 |
0.086
|
|
|
|
negative regulation of voltage gated calcium channel activity
|
GO:1901386 |
4 |
0.084
|
|
|
|
response to disaccharide
|
GO:0034285 |
1 |
0.084
|
|
|
|
cellular response to oxygen containing compound
|
GO:1901701 |
276 |
0.083
|
|
|
|
purine ribonucleoside monophosphate metabolic process
|
GO:0009167 |
186 |
0.082
|
|
|
|
positive regulation of transport
|
GO:0051050 |
336 |
0.081
|
|
|
|
atp metabolic process
|
GO:0046034 |
176 |
0.080
|
|
|
|
regulation of nervous system development
|
GO:0051960 |
88 |
0.080
|
|
|
|
cell projection organization
|
GO:0030030 |
252 |
0.080
|
|
|
|
regulation of nucleotide biosynthetic process
|
GO:0030808 |
50 |
0.074
|
Fly |
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
267 |
0.072
|
Fly |
|
|
cell morphogenesis
|
GO:0000902 |
296 |
0.071
|
|
|
|
guanosine containing compound metabolic process
|
GO:1901068 |
244 |
0.070
|
|
|
|
regulation of nucleoside metabolic process
|
GO:0009118 |
209 |
0.070
|
|
|
|
ion homeostasis
|
GO:0050801 |
230 |
0.070
|
|
|
|
regulation of system process
|
GO:0044057 |
101 |
0.070
|
|
|
|
organ morphogenesis
|
GO:0009887 |
147 |
0.067
|
|
|
|
regulation of secretion
|
GO:0051046 |
194 |
0.066
|
Fly |
|
|
head development
|
GO:0060322 |
108 |
0.066
|
|
|
|
regulation of mapk cascade
|
GO:0043408 |
262 |
0.066
|
|
|
|
regulation of short term neuronal synaptic plasticity
|
GO:0048172 |
1 |
0.063
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.062
|
|
|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.062
|
|
|
|
anatomical structure formation involved in morphogenesis
|
GO:0048646 |
284 |
0.062
|
|
|
|
establishment of protein localization to membrane
|
GO:0090150 |
121 |
0.062
|
|
|
|
central nervous system development
|
GO:0007417 |
123 |
0.062
|
|
|
|
endomembrane system organization
|
GO:0010256 |
196 |
0.061
|
|
|
|
positive regulation of synaptic transmission
|
GO:0050806 |
4 |
0.061
|
|
|
|
response to abiotic stimulus
|
GO:0009628 |
336 |
0.061
|
|
|
|
regulation of cellular component movement
|
GO:0051270 |
334 |
0.059
|
|
|
|
purine ribonucleoside triphosphate catabolic process
|
GO:0009207 |
391 |
0.059
|
|
|
|
cellular response to endogenous stimulus
|
GO:0071495 |
336 |
0.059
|
|
|
|
post embryonic development
|
GO:0009791 |
2 |
0.059
|
|
|
|
neuromuscular junction development
|
GO:0007528 |
3 |
0.058
|
|
|
|
organonitrogen compound biosynthetic process
|
GO:1901566 |
200 |
0.058
|
Fly |
|
|
regulation of gtp catabolic process
|
GO:0033124 |
180 |
0.058
|
|
|
|
regulation of exocytosis
|
GO:0017157 |
46 |
0.057
|
Fly |
|
|
endocytosis
|
GO:0006897 |
159 |
0.057
|
|
|
|
adenylate cyclase inhibiting g protein coupled glutamate receptor signaling pathway
|
GO:0007196 |
4 |
0.056
|
|
|
|
protein localization to plasma membrane
|
GO:0072659 |
93 |
0.056
|
|
|
|
regulation of small gtpase mediated signal transduction
|
GO:0051056 |
156 |
0.056
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
289 |
0.055
|
|
|
|
positive regulation of cellular catabolic process
|
GO:0031331 |
284 |
0.055
|
|
|
|
actin filament based process
|
GO:0030029 |
224 |
0.054
|
|
|
|
cellular response to disaccharide stimulus
|
GO:0071324 |
1 |
0.054
|
|
|
|
regulation of neurotransmitter secretion
|
GO:0046928 |
3 |
0.054
|
Fly |
|
|
positive regulation of purine nucleotide catabolic process
|
GO:0033123 |
185 |
0.054
|
|
|
|
blood circulation
|
GO:0008015 |
113 |
0.054
|
|
|
|
organ formation
|
GO:0048645 |
3 |
0.053
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
179 |
0.052
|
|
|
|
spinal cord development
|
GO:0021510 |
4 |
0.052
|
|
|
|
forebrain generation of neurons
|
GO:0021872 |
3 |
0.052
|
|
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
190 |
0.052
|
|
|
|
autophagic vacuole assembly
|
GO:0000045 |
19 |
0.051
|
|
|
|
divalent inorganic cation transport
|
GO:0072511 |
158 |
0.051
|
|
|
|
regulation of acrosome reaction
|
GO:0060046 |
4 |
0.049
|
|
|
|
regulation of metal ion transport
|
GO:0010959 |
120 |
0.049
|
|
|
|
divalent inorganic cation homeostasis
|
GO:0072507 |
136 |
0.049
|
|
|
|
blood vessel development
|
GO:0001568 |
172 |
0.048
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.048
|
|
|
|
peripheral nervous system development
|
GO:0007422 |
2 |
0.048
|
|
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
313 |
0.048
|
|
|
|
fibroblast growth factor receptor signaling pathway involved in mammary gland specification
|
GO:0060595 |
1 |
0.047
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
80 |
0.047
|
|
|
|
chemical homeostasis
|
GO:0048878 |
306 |
0.046
|
|
|
|
adult locomotory behavior
|
GO:0008344 |
1 |
0.045
|
|
|
|
regulation of cell migration
|
GO:0030334 |
289 |
0.045
|
|
|
|
neuron differentiation
|
GO:0030182 |
138 |
0.045
|
|
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.044
|
|
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.044
|
|
|
|
atp catabolic process
|
GO:0006200 |
157 |
0.043
|
|
|
|
purine ribonucleoside catabolic process
|
GO:0046130 |
398 |
0.043
|
|
|
|
synaptic vesicle endocytosis
|
GO:0048488 |
2 |
0.043
|
|
|
|
calcium ion transport
|
GO:0006816 |
147 |
0.043
|
|
|
|
brain development
|
GO:0007420 |
97 |
0.043
|
|
|
|
positive regulation of camp biosynthetic process
|
GO:0030819 |
35 |
0.043
|
|
|
|
cell projection morphogenesis
|
GO:0048858 |
129 |
0.042
|
|
|
|
ribose phosphate biosynthetic process
|
GO:0046390 |
82 |
0.042
|
Fly |
|
|
regulation of cell differentiation
|
GO:0045595 |
393 |
0.042
|
|
|
|
protein complex disassembly
|
GO:0043241 |
52 |
0.042
|
|
|
|
positive regulation of gtp catabolic process
|
GO:0033126 |
166 |
0.042
|
|
|
|
establishment of protein localization to plasma membrane
|
GO:0090002 |
68 |
0.042
|
|
|
|
positive regulation of ras gtpase activity
|
GO:0032320 |
117 |
0.042
|
|
|
|
regulation of map kinase activity
|
GO:0043405 |
108 |
0.042
|
|
|
|
organic hydroxy compound metabolic process
|
GO:1901615 |
147 |
0.042
|
|
|
|
positive regulation of transferase activity
|
GO:0051347 |
227 |
0.041
|
|
|
|
metal ion homeostasis
|
GO:0055065 |
169 |
0.041
|
|
|
|
cellular homeostasis
|
GO:0019725 |
196 |
0.041
|
|
|
|
behavior
|
GO:0007610 |
112 |
0.041
|
Fly |
|
|
negative regulation of transport
|
GO:0051051 |
176 |
0.041
|
Fly |
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
379 |
0.040
|
|
|
|
cellular component disassembly
|
GO:0022411 |
92 |
0.040
|
|
|
|
metencephalon development
|
GO:0022037 |
2 |
0.040
|
|
|
|
negative regulation of multicellular organismal process
|
GO:0051241 |
317 |
0.040
|
|
|
|
vasculature development
|
GO:0001944 |
181 |
0.040
|
|
|
|
regulation of homeostatic process
|
GO:0032844 |
121 |
0.040
|
|
|
|
regulation of ion transmembrane transporter activity
|
GO:0032412 |
72 |
0.039
|
|
|
|
negative regulation of programmed cell death
|
GO:0043069 |
321 |
0.039
|
|
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
391 |
0.039
|
|
|
|
sequestering of metal ion
|
GO:0051238 |
24 |
0.039
|
|
|
|
signal transduction by phosphorylation
|
GO:0023014 |
297 |
0.039
|
|
|
|
ribonucleoside catabolic process
|
GO:0042454 |
406 |
0.038
|
|
|
|
cerebellum development
|
GO:0021549 |
2 |
0.038
|
|
|
|
cell adhesion
|
GO:0007155 |
325 |
0.037
|
|
|
|
rho protein signal transduction
|
GO:0007266 |
26 |
0.037
|
|
|
|
camp mediated signaling
|
GO:0019933 |
23 |
0.036
|
|
|
|
regeneration
|
GO:0031099 |
4 |
0.036
|
|
|
|
associative learning
|
GO:0008306 |
1 |
0.036
|
|
|
|
cellular macromolecular complex assembly
|
GO:0034622 |
324 |
0.036
|
|
|
|
regulation of transporter activity
|
GO:0032409 |
82 |
0.036
|
|
|
|
detection of stimulus
|
GO:0051606 |
85 |
0.035
|
|
|
|
negative regulation of cellular amine metabolic process
|
GO:0033239 |
3 |
0.035
|
|
|
|
adenylate cyclase inhibiting g protein coupled receptor signaling pathway
|
GO:0007193 |
22 |
0.035
|
Human |
|
|
cellular response to corticotropin releasing hormone stimulus
|
GO:0071376 |
1 |
0.035
|
|
|
|
positive regulation of nucleotide biosynthetic process
|
GO:0030810 |
38 |
0.035
|
|
|
|
regulation of neurogenesis
|
GO:0050767 |
82 |
0.035
|
|
|
|
cardiovascular system development
|
GO:0072358 |
262 |
0.035
|
|
|
|
intracellular protein transport
|
GO:0006886 |
270 |
0.034
|
|
|
|
positive regulation of mapk cascade
|
GO:0043410 |
190 |
0.034
|
|
|
|
positive regulation of purine nucleotide biosynthetic process
|
GO:1900373 |
38 |
0.034
|
|
|
|
cellular metal ion homeostasis
|
GO:0006875 |
146 |
0.034
|
|
|
|
purine nucleoside monophosphate catabolic process
|
GO:0009128 |
158 |
0.034
|
|
|
|
multicellular organismal response to stress
|
GO:0033555 |
1 |
0.034
|
|
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.034
|
|
|
|
positive regulation of cyclic nucleotide biosynthetic process
|
GO:0030804 |
38 |
0.034
|
|
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.034
|
|
|
|
gtp catabolic process
|
GO:0006184 |
237 |
0.034
|
|
|
|
lipid metabolic process
|
GO:0006629 |
381 |
0.034
|
|
|
|
positive regulation of gtpase activity
|
GO:0043547 |
166 |
0.034
|
|
|
|
cation homeostasis
|
GO:0055080 |
189 |
0.033
|
|
|
|
calcium ion transmembrane transport
|
GO:0070588 |
76 |
0.033
|
|
|
|
cell part morphogenesis
|
GO:0032990 |
137 |
0.033
|
|
|
|
positive regulation of growth hormone secretion
|
GO:0060124 |
2 |
0.033
|
|
|
|
regulation of atrial cardiac muscle cell membrane repolarization
|
GO:0060372 |
4 |
0.033
|
|
|
|
epithelial tube branching involved in lung morphogenesis
|
GO:0060441 |
4 |
0.033
|
|
|
|
forebrain neuron differentiation
|
GO:0021879 |
3 |
0.033
|
|
|
|
morphogenesis of embryonic epithelium
|
GO:0016331 |
4 |
0.033
|
|
|
|
mitotic cell cycle
|
GO:0000278 |
326 |
0.033
|
|
|
|
response to lipid
|
GO:0033993 |
206 |
0.032
|
|
|
|
golgi organization
|
GO:0007030 |
38 |
0.032
|
|
|
|
gtp metabolic process
|
GO:0046039 |
239 |
0.032
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
183 |
0.032
|
|
|
|
specification of organ identity
|
GO:0010092 |
3 |
0.032
|
|
|
|
negative regulation of developmental process
|
GO:0051093 |
247 |
0.032
|
|
|
|
cellular potassium ion transport
|
GO:0071804 |
60 |
0.031
|
|
|
|
blood vessel morphogenesis
|
GO:0048514 |
162 |
0.031
|
|
|
|
forebrain regionalization
|
GO:0021871 |
3 |
0.031
|
|
|
|
neuroblast proliferation
|
GO:0007405 |
4 |
0.031
|
|
|
|
negative regulation of protein modification process
|
GO:0031400 |
200 |
0.031
|
|
|
|
female gamete generation
|
GO:0007292 |
2 |
0.031
|
|
|
|
circulatory system development
|
GO:0072359 |
262 |
0.031
|
|
|
|
macroautophagy
|
GO:0016236 |
39 |
0.030
|
|
|
|
cellular response to starvation
|
GO:0009267 |
58 |
0.030
|
|
|
|
regulation of ras protein signal transduction
|
GO:0046578 |
155 |
0.030
|
|
|
|
startle response
|
GO:0001964 |
3 |
0.030
|
|
|
|
cellular response to external stimulus
|
GO:0071496 |
111 |
0.030
|
|
|
|
response to sucrose
|
GO:0009744 |
1 |
0.030
|
|
|
|
single organism cellular localization
|
GO:1902580 |
332 |
0.030
|
|
|
|
cell growth
|
GO:0016049 |
160 |
0.030
|
|
|
|
second messenger mediated signaling
|
GO:0019932 |
78 |
0.030
|
|
|
|
muscle system process
|
GO:0003012 |
81 |
0.029
|
|
|
|
bud outgrowth involved in lung branching
|
GO:0060447 |
1 |
0.029
|
|
|
|
response to corticotropin releasing hormone
|
GO:0043435 |
1 |
0.029
|
|
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
331 |
0.029
|
|
|
|
protein homooligomerization
|
GO:0051260 |
100 |
0.029
|
|
|
|
positive regulation of cellular component movement
|
GO:0051272 |
181 |
0.029
|
|
|
|
motor neuron axon guidance
|
GO:0008045 |
2 |
0.029
|
|
|
|
negative regulation of synaptic transmission
|
GO:0050805 |
2 |
0.029
|
Fly |
|
|
sensory perception of pain
|
GO:0019233 |
4 |
0.029
|
|
|
|
regulation of cell morphogenesis
|
GO:0022604 |
153 |
0.028
|
|
|
|
regulation of calcium ion transport
|
GO:0051924 |
79 |
0.028
|
|
|
|
rhythmic behavior
|
GO:0007622 |
2 |
0.028
|
|
|
|
segmentation
|
GO:0035282 |
4 |
0.028
|
|
|
|
cellular response to organonitrogen compound
|
GO:0071417 |
124 |
0.028
|
|
|
|
oogenesis
|
GO:0048477 |
2 |
0.028
|
|
|
|
inner ear morphogenesis
|
GO:0042472 |
4 |
0.028
|
|
|
|
regulation of cell motility
|
GO:2000145 |
299 |
0.028
|
|
|
|
cell fate determination
|
GO:0001709 |
3 |
0.028
|
|
|
|
cellular component morphogenesis
|
GO:0032989 |
314 |
0.028
|
|
|
|
peptidyl tyrosine modification
|
GO:0018212 |
170 |
0.028
|
|
|
|
receptor internalization
|
GO:0031623 |
43 |
0.028
|
|
|
|
multicellular organismal aging
|
GO:0010259 |
3 |
0.028
|
|
|
|
positive regulation of purine nucleotide metabolic process
|
GO:1900544 |
227 |
0.027
|
|
|
|
purine ribonucleoside monophosphate catabolic process
|
GO:0009169 |
158 |
0.027
|
|
|
|
positive regulation of protein complex assembly
|
GO:0031334 |
86 |
0.027
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
204 |
0.027
|
|
|
|
positive regulation of acrosome reaction
|
GO:2000344 |
4 |
0.027
|
|
|
|
muscle contraction
|
GO:0006936 |
73 |
0.027
|
|
|
|
golgi vesicle transport
|
GO:0048193 |
80 |
0.027
|
|
|
|
sequestering of calcium ion
|
GO:0051208 |
17 |
0.027
|
|
|
|
nerve development
|
GO:0021675 |
4 |
0.026
|
|
|
|
regulation of protein complex assembly
|
GO:0043254 |
147 |
0.026
|
|
|
|
sodium ion transmembrane transport
|
GO:0035725 |
59 |
0.026
|
|
|
|
determination of adult lifespan
|
GO:0008340 |
2 |
0.026
|
|
|
|
organelle localization
|
GO:0051640 |
84 |
0.026
|
Fly |
|
|
synaptic vesicle recycling
|
GO:0036465 |
3 |
0.026
|
|
|
|
activation of protein kinase activity
|
GO:0032147 |
90 |
0.026
|
|
|
|
regulation of cellular response to stress
|
GO:0080135 |
244 |
0.026
|
|
|
|
positive regulation of cell motility
|
GO:2000147 |
177 |
0.026
|
|
|
|
neuron projection regeneration
|
GO:0031102 |
1 |
0.026
|
|
|
|
circulatory system process
|
GO:0003013 |
113 |
0.025
|
|
|
|
regulation of ras gtpase activity
|
GO:0032318 |
128 |
0.025
|
|
|
|
negative regulation of cell differentiation
|
GO:0045596 |
171 |
0.025
|
|
|
|
positive regulation of cell development
|
GO:0010720 |
92 |
0.025
|
|
|
|
dephosphorylation
|
GO:0016311 |
209 |
0.025
|
|
|
|
cellular response to nutrient levels
|
GO:0031669 |
69 |
0.025
|
|
|
|
regulation of vesicle mediated transport
|
GO:0060627 |
130 |
0.025
|
Fly |
|
|
neuron development
|
GO:0048666 |
113 |
0.025
|
|
|
|
action potential
|
GO:0001508 |
34 |
0.025
|
|
|
|
positive regulation of cell proliferation
|
GO:0008284 |
301 |
0.024
|
|
|
|
chromatin modification
|
GO:0016568 |
298 |
0.024
|
|
|
|
negative regulation of cellular amino acid metabolic process
|
GO:0045763 |
2 |
0.024
|
|
|
|
single organism cell adhesion
|
GO:0098602 |
179 |
0.024
|
|
|
|
cell differentiation in spinal cord
|
GO:0021515 |
1 |
0.024
|
|
|
|
cell cycle phase transition
|
GO:0044770 |
173 |
0.024
|
|
|
|
mitotic cell cycle process
|
GO:1903047 |
286 |
0.024
|
|
|
|
positive regulation of camp metabolic process
|
GO:0030816 |
41 |
0.024
|
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
249 |
0.024
|
|
|
|
positive regulation of locomotion
|
GO:0040017 |
186 |
0.024
|
|
|
|
macromolecular complex disassembly
|
GO:0032984 |
60 |
0.024
|
|
|
|
mating
|
GO:0007618 |
1 |
0.024
|
|
|
|
regulation of ion homeostasis
|
GO:2000021 |
73 |
0.023
|
|
|
|
positive regulation of protein serine threonine kinase activity
|
GO:0071902 |
119 |
0.023
|
|
|
|
epithelium development
|
GO:0060429 |
227 |
0.023
|
|
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
380 |
0.023
|
|
|
|
cytosolic calcium ion homeostasis
|
GO:0051480 |
89 |
0.023
|
|
|
|
regulation of cell cycle process
|
GO:0010564 |
266 |
0.023
|
|
|
|
anterior posterior axis specification
|
GO:0009948 |
2 |
0.023
|
|
|
|
protein localization to membrane
|
GO:0072657 |
160 |
0.023
|
|
|
|
regulation of heart contraction
|
GO:0008016 |
50 |
0.023
|
|
|
|
divalent metal ion transport
|
GO:0070838 |
152 |
0.023
|
|
|
|
positive regulation of blood pressure
|
GO:0045777 |
3 |
0.023
|
|
|
|
positive regulation of ion transport
|
GO:0043270 |
87 |
0.023
|
|
|
|
developmental growth
|
GO:0048589 |
48 |
0.023
|
|
|
|
positive regulation of cytosolic calcium ion concentration
|
GO:0007204 |
82 |
0.022
|
|
|
|
synaptic vesicle exocytosis
|
GO:0016079 |
3 |
0.022
|
Fly |
|
|
neural crest cell development
|
GO:0014032 |
3 |
0.022
|
|
|
|
negative regulation of cellular component organization
|
GO:0051129 |
235 |
0.022
|
Fly |
|
|
covalent chromatin modification
|
GO:0016569 |
254 |
0.022
|
|
|
|
sodium ion transport
|
GO:0006814 |
61 |
0.022
|
|
|
|
gamma aminobutyric acid signaling pathway
|
GO:0007214 |
3 |
0.022
|
|
|
|
negative regulation of transcription from rna polymerase ii promoter
|
GO:0000122 |
281 |
0.022
|
|
|
|
negative regulation of cell motility
|
GO:2000146 |
104 |
0.022
|
|
|
|
positive regulation of cell differentiation
|
GO:0045597 |
211 |
0.021
|
|
|
|
negative regulation of phosphorylation
|
GO:0042326 |
174 |
0.021
|
|
|
|
regulation of transmission of nerve impulse
|
GO:0051969 |
2 |
0.021
|
|
|
|
cellular protein catabolic process
|
GO:0044257 |
261 |
0.021
|
|
|
|
regulation of neuron differentiation
|
GO:0045664 |
70 |
0.021
|
|
|
|
cellular cation homeostasis
|
GO:0030003 |
163 |
0.021
|
|
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
140 |
0.021
|
|
|
|
negative regulation of hydrolase activity
|
GO:0051346 |
182 |
0.021
|
|
|
|
synaptic vesicle localization
|
GO:0097479 |
5 |
0.021
|
Fly |
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
211 |
0.021
|
|
|
|
protein catabolic process
|
GO:0030163 |
325 |
0.021
|
|
|
|
oocyte development
|
GO:0048599 |
1 |
0.021
|
|
|
|
protein modification by small protein conjugation
|
GO:0032446 |
342 |
0.021
|
|
|
|
regulation of anatomical structure morphogenesis
|
GO:0022603 |
286 |
0.021
|
|
|
|
positive regulation of nucleotide catabolic process
|
GO:0030813 |
185 |
0.021
|
|
|
|
cellular ion homeostasis
|
GO:0006873 |
168 |
0.021
|
|
|
|
thymus development
|
GO:0048538 |
3 |
0.020
|
|
|
|
cell division
|
GO:0051301 |
168 |
0.020
|
|
|
|
protein ubiquitination
|
GO:0016567 |
314 |
0.020
|
|
|
|
regulation of purine nucleotide catabolic process
|
GO:0033121 |
205 |
0.020
|
|
|
|
mitotic cell cycle phase transition
|
GO:0044772 |
162 |
0.020
|
|
|
|
regulation of synaptic vesicle transport
|
GO:1902803 |
3 |
0.020
|
Fly |
|
|
actin cytoskeleton organization
|
GO:0030036 |
207 |
0.020
|
|
|
|
axon regeneration
|
GO:0031103 |
1 |
0.020
|
|
|
|
enzyme linked receptor protein signaling pathway
|
GO:0007167 |
303 |
0.020
|
|
|
|
cell projection assembly
|
GO:0030031 |
126 |
0.020
|
|
|
|
forelimb morphogenesis
|
GO:0035136 |
4 |
0.020
|
|
|
|
regulation of synaptic vesicle exocytosis
|
GO:2000300 |
2 |
0.020
|
Fly |
|
|
cellular response to nitrogen compound
|
GO:1901699 |
144 |
0.020
|
|
|
|
peptidyl tyrosine phosphorylation
|
GO:0018108 |
170 |
0.020
|
|
|
|
reactive oxygen species biosynthetic process
|
GO:1903409 |
4 |
0.020
|
|
|
|
regulation of proteolysis
|
GO:0030162 |
293 |
0.020
|
|
|
|
neuropeptide signaling pathway
|
GO:0007218 |
19 |
0.020
|
|
|
|
small molecule biosynthetic process
|
GO:0044283 |
157 |
0.020
|
|
|
|
protein localization to organelle
|
GO:0033365 |
280 |
0.019
|
|
|
|
calcium ion transport into cytosol
|
GO:0060402 |
48 |
0.019
|
|
|
|
cellular chemical homeostasis
|
GO:0055082 |
180 |
0.019
|
|
|
|
cellular response to organic cyclic compound
|
GO:0071407 |
127 |
0.019
|
|
|
|
positive regulation of cyclic nucleotide metabolic process
|
GO:0030801 |
49 |
0.019
|
|
|
|
regulation of male gonad development
|
GO:2000018 |
4 |
0.019
|
|
|
|
epithelial cell differentiation
|
GO:0030855 |
141 |
0.019
|
|
|
|
organelle assembly
|
GO:0070925 |
176 |
0.019
|
|
|
|
cellular protein complex disassembly
|
GO:0043624 |
36 |
0.019
|
|
|
|
taxis
|
GO:0042330 |
157 |
0.019
|
|
|
|
maintenance of location
|
GO:0051235 |
112 |
0.019
|
|
|
|
cell proliferation in forebrain
|
GO:0021846 |
1 |
0.019
|
|
|
|
neuron projection development
|
GO:0031175 |
106 |
0.019
|
|
|
|
positive regulation of aldosterone metabolic process
|
GO:0032346 |
2 |
0.019
|
|
|
|
negative regulation of gliogenesis
|
GO:0014014 |
3 |
0.019
|
|
|
|
microtubule based process
|
GO:0007017 |
210 |
0.019
|
|
|
|
positive regulation of catabolic process
|
GO:0009896 |
310 |
0.019
|
|
|
|
single organism membrane fusion
|
GO:0044801 |
37 |
0.019
|
Fly |
|
|
sex determination
|
GO:0007530 |
3 |
0.019
|
|
|
|
positive regulation of keratinocyte migration
|
GO:0051549 |
4 |
0.019
|
|
|
|
positive regulation of monocyte chemotactic protein 1 production
|
GO:0071639 |
3 |
0.019
|
|
|
|
protein o linked glycosylation via serine
|
GO:0018242 |
3 |
0.018
|
|
|
|
cardiac right ventricle morphogenesis
|
GO:0003215 |
3 |
0.018
|
|
|
|
limbic system development
|
GO:0021761 |
3 |
0.018
|
|
|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
181 |
0.018
|
|
|
|
positive regulation of sequence specific dna binding transcription factor activity
|
GO:0051091 |
131 |
0.018
|
|
|
|
histone modification
|
GO:0016570 |
251 |
0.018
|
|
|
|
cardiac muscle cell contraction
|
GO:0086003 |
4 |
0.018
|
|
|
|
negative regulation of transferase activity
|
GO:0051348 |
124 |
0.018
|
|
|
|
sensory perception of sound
|
GO:0007605 |
37 |
0.018
|
|
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
244 |
0.018
|
|
|
|
steroid metabolic process
|
GO:0008202 |
94 |
0.018
|
|
|
|
positive regulation of adenylate cyclase activity
|
GO:0045762 |
12 |
0.018
|
|
|
|
potassium ion transmembrane transport
|
GO:0071805 |
60 |
0.018
|
|
