|
|
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
|
GO:1901030 |
3 |
0.997
|
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
249 |
0.928
|
|
|
|
apoptotic mitochondrial changes
|
GO:0008637 |
57 |
0.880
|
|
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
313 |
0.776
|
|
|
|
positive regulation of cell death
|
GO:0010942 |
263 |
0.766
|
|
|
|
activation of mapkkk activity
|
GO:0000185 |
7 |
0.758
|
|
|
|
signal transduction in response to dna damage
|
GO:0042770 |
57 |
0.750
|
|
|
|
cellular response to endogenous stimulus
|
GO:0071495 |
336 |
0.686
|
|
|
|
phosphatidic acid biosynthetic process
|
GO:0006654 |
4 |
0.667
|
|
|
|
covalent chromatin modification
|
GO:0016569 |
254 |
0.622
|
|
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.611
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.607
|
|
|
|
apoptotic signaling pathway
|
GO:0097190 |
268 |
0.589
|
|
|
|
positive regulation of mitochondrion organization
|
GO:0010822 |
30 |
0.569
|
|
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
391 |
0.523
|
Mouse |
|
|
canonical wnt signaling pathway involved in cardiac muscle cell fate commitment
|
GO:0061317 |
3 |
0.516
|
|
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
267 |
0.502
|
Mouse |
|
|
organelle fission
|
GO:0048285 |
149 |
0.485
|
|
|
|
positive regulation of apoptotic signaling pathway
|
GO:2001235 |
70 |
0.470
|
|
|
|
negative regulation of protein processing
|
GO:0010955 |
142 |
0.443
|
|
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
175 |
0.441
|
|
|
|
mitochondrial membrane organization
|
GO:0007006 |
40 |
0.440
|
|
|
|
cellular response to mechanical stimulus
|
GO:0071260 |
39 |
0.428
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.420
|
|
|
|
vasculature development
|
GO:0001944 |
181 |
0.393
|
|
|
|
regulation of cellular component biogenesis
|
GO:0044087 |
281 |
0.385
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
6 |
0.384
|
|
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.371
|
Mouse |
|
|
regulation of proteolysis
|
GO:0030162 |
293 |
0.363
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
41 |
0.362
|
|
|
|
mitochondrial outer membrane permeabilization
|
GO:0097345 |
15 |
0.329
|
|
|
|
epithelium development
|
GO:0060429 |
227 |
0.327
|
|
|
|
positive regulation of organelle organization
|
GO:0010638 |
195 |
0.307
|
|
|
|
positive regulation of stress activated mapk cascade
|
GO:0032874 |
60 |
0.305
|
|
|
|
mitotic cell cycle
|
GO:0000278 |
326 |
0.303
|
|
|
|
positive regulation of apoptotic process
|
GO:0043065 |
246 |
0.303
|
|
|
|
negative regulation of transcription from rna polymerase ii promoter
|
GO:0000122 |
281 |
0.300
|
|
|
|
glycerolipid metabolic process
|
GO:0046486 |
107 |
0.277
|
|
|
|
regulation of mitochondrion organization
|
GO:0010821 |
54 |
0.276
|
|
|
|
negative regulation of cell proliferation
|
GO:0008285 |
228 |
0.275
|
|
|
|
phosphatidic acid metabolic process
|
GO:0046473 |
5 |
0.269
|
|
|
|
protein maturation
|
GO:0051604 |
233 |
0.261
|
|
|
|
regulation of endopeptidase activity
|
GO:0052548 |
170 |
0.257
|
|
|
|
neurofilament bundle assembly
|
GO:0033693 |
2 |
0.255
|
|
|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.253
|
|
|
|
regulation of mitochondrial membrane permeability
|
GO:0046902 |
25 |
0.249
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.244
|
|
|
|
demethylation
|
GO:0070988 |
37 |
0.224
|
|
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.224
|
|
|
|
positive regulation of cellular component biogenesis
|
GO:0044089 |
158 |
0.218
|
|
|
|
protein processing
|
GO:0016485 |
226 |
0.215
|
|
|
|
negative regulation of protein maturation
|
GO:1903318 |
142 |
0.210
|
|
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
267 |
0.208
|
Mouse |
|
|
regeneration
|
GO:0031099 |
4 |
0.207
|
|
|
|
anatomical structure formation involved in morphogenesis
|
GO:0048646 |
284 |
0.205
|
|
|
|
cellular response to abiotic stimulus
|
GO:0071214 |
117 |
0.202
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
80 |
0.202
|
|
|
|
positive regulation of transferase activity
|
GO:0051347 |
227 |
0.201
|
|
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
379 |
0.200
|
|
|
|
protein folding
|
GO:0006457 |
38 |
0.199
|
|
|
|
chromatin modification
|
GO:0016568 |
298 |
0.199
|
|
|
|
protein demethylation
|
GO:0006482 |
17 |
0.196
|
|
|
|
defense response to other organism
|
GO:0098542 |
129 |
0.196
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.192
|
|
|
|
response to abiotic stimulus
|
GO:0009628 |
336 |
0.191
|
|
|
|
blood vessel morphogenesis
|
GO:0048514 |
162 |
0.189
|
|
|
|
regulation of mitochondrial membrane permeability involved in apoptotic process
|
GO:1902108 |
18 |
0.189
|
|
|
|
positive regulation of mitochondrial membrane permeability
|
GO:0035794 |
17 |
0.182
|
|
|
|
negative regulation of phosphorylation
|
GO:0042326 |
174 |
0.182
|
Mouse |
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.178
|
Mouse |
|
|
glycerolipid biosynthetic process
|
GO:0045017 |
51 |
0.177
|
|
|
|
hemopoiesis
|
GO:0030097 |
180 |
0.172
|
|
|
|
ion transmembrane transport
|
GO:0034220 |
338 |
0.170
|
|
|
|
intracellular receptor signaling pathway
|
GO:0030522 |
104 |
0.167
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
11 |
0.166
|
|
|
|
regulation of protein oligomerization
|
GO:0032459 |
26 |
0.166
|
|
|
|
positive regulation of proteolysis
|
GO:0045862 |
142 |
0.165
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
7 |
0.158
|
|
|
|
immune effector process
|
GO:0002252 |
159 |
0.157
|
|
|
|
response to hormone
|
GO:0009725 |
175 |
0.151
|
|
|
|
positive regulation of cellular component organization
|
GO:0051130 |
376 |
0.148
|
|
|
|
response to biotic stimulus
|
GO:0009607 |
276 |
0.147
|
|
|
|
lipid biosynthetic process
|
GO:0008610 |
177 |
0.147
|
|
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.143
|
|
|
|
cellular response to oxygen containing compound
|
GO:1901701 |
276 |
0.143
|
|
|
|
response to lithium ion
|
GO:0010226 |
2 |
0.139
|
|
|
|
regulation of cell cycle
|
GO:0051726 |
393 |
0.138
|
Mouse |
|
|
locomotory behavior
|
GO:0007626 |
1 |
0.135
|
|
|
|
regulation of cell cycle process
|
GO:0010564 |
266 |
0.135
|
|
|
|
nuclear division
|
GO:0000280 |
128 |
0.128
|
|
|
|
regulation of peptidase activity
|
GO:0052547 |
180 |
0.121
|
|
|
|
negative regulation of peptidase activity
|
GO:0010466 |
91 |
0.119
|
|
|
|
regulation of endothelial cell migration
|
GO:0010594 |
67 |
0.118
|
|
|
|
regulation of cellular response to stress
|
GO:0080135 |
244 |
0.118
|
|
|
|
response to organonitrogen compound
|
GO:0010243 |
156 |
0.118
|
|
|
|
cell cycle phase transition
|
GO:0044770 |
173 |
0.118
|
|
|
|
mitochondrial outer membrane permeabilization involved in programmed cell death
|
GO:1902686 |
16 |
0.117
|
|
|
|
regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043281 |
116 |
0.117
|
|
|
|
regulation of stress activated mapk cascade
|
GO:0032872 |
84 |
0.114
|
|
|
|
response to ionizing radiation
|
GO:0010212 |
65 |
0.112
|
|
|
|
regulation of gtp catabolic process
|
GO:0033124 |
180 |
0.111
|
|
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
211 |
0.111
|
|
|
|
regulation of membrane permeability
|
GO:0090559 |
25 |
0.111
|
|
|
|
tissue regeneration
|
GO:0042246 |
3 |
0.111
|
|
|
|
response to calcium ion
|
GO:0051592 |
46 |
0.109
|
|
|
|
histone demethylation
|
GO:0016577 |
15 |
0.108
|
|
|
|
protein polyubiquitination
|
GO:0000209 |
110 |
0.108
|
|
|
|
regulation of cysteine type endopeptidase activity
|
GO:2000116 |
127 |
0.107
|
|
|
|
negative regulation of protein modification process
|
GO:0031400 |
200 |
0.107
|
Mouse |
|
|
mitochondrial transport
|
GO:0006839 |
60 |
0.107
|
|
|
|
negative regulation of programmed cell death
|
GO:0043069 |
321 |
0.107
|
|
|
|
cellular response to hormone stimulus
|
GO:0032870 |
125 |
0.105
|
|
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.105
|
|
|
|
i kappab kinase nf kappab signaling
|
GO:0007249 |
166 |
0.104
|
|
|
|
establishment of protein localization to mitochondrion
|
GO:0072655 |
22 |
0.104
|
|
|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
181 |
0.104
|
|
|
|
regulation of mapk cascade
|
GO:0043408 |
262 |
0.103
|
|
|
|
response to uv
|
GO:0009411 |
73 |
0.103
|
|
|
|
response to oxygen containing compound
|
GO:1901700 |
369 |
0.103
|
|
|
|
regulation of cell differentiation
|
GO:0045595 |
393 |
0.102
|
|
|
|
regulation of establishment of protein localization
|
GO:0070201 |
242 |
0.102
|
|
|
|
response to drug
|
GO:0042493 |
81 |
0.101
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
204 |
0.100
|
|
|
|
response to other organism
|
GO:0051707 |
261 |
0.099
|
|
|
|
negative regulation of cell cycle
|
GO:0045786 |
193 |
0.098
|
|
|
|
negative regulation of transferase activity
|
GO:0051348 |
124 |
0.098
|
Mouse |
|
|
response to external biotic stimulus
|
GO:0043207 |
261 |
0.098
|
|
|
|
regulation of protein processing
|
GO:0070613 |
150 |
0.096
|
|
|
|
regulation of neuronal synaptic plasticity
|
GO:0048168 |
1 |
0.096
|
|
|
|
mitochondrion organization
|
GO:0007005 |
156 |
0.095
|
|
|
|
nucleotide catabolic process
|
GO:0009166 |
408 |
0.095
|
|
|
|
chromatin organization
|
GO:0006325 |
351 |
0.095
|
|
|
|
negative regulation of proteolysis
|
GO:0045861 |
132 |
0.093
|
|
|
|
positive regulation of cellular catabolic process
|
GO:0031331 |
284 |
0.091
|
|
|
|
muscle structure development
|
GO:0061061 |
98 |
0.090
|
|
|
|
positive regulation of cell proliferation
|
GO:0008284 |
301 |
0.089
|
|
|
|
mitotic cell cycle process
|
GO:1903047 |
286 |
0.089
|
|
|
|
histone lysine demethylation
|
GO:0070076 |
14 |
0.088
|
|
|
|
regulation of anatomical structure morphogenesis
|
GO:0022603 |
286 |
0.087
|
|
|
|
epithelial cell differentiation
|
GO:0030855 |
141 |
0.087
|
|
|
|
protein ubiquitination
|
GO:0016567 |
314 |
0.087
|
|
|
|
purine containing compound catabolic process
|
GO:0072523 |
411 |
0.087
|
|
|
|
protein dealkylation
|
GO:0008214 |
17 |
0.086
|
|
|
|
positive regulation of mitochondrial membrane permeability involved in apoptotic process
|
GO:1902110 |
16 |
0.083
|
|
|
|
inositol phosphate mediated signaling
|
GO:0048016 |
16 |
0.083
|
|
|
|
proteasomal protein catabolic process
|
GO:0010498 |
176 |
0.082
|
|
|
|
cell cycle checkpoint
|
GO:0000075 |
117 |
0.081
|
|
|
|
positive regulation of protein complex assembly
|
GO:0031334 |
86 |
0.081
|
|
|
|
cellular response to ionizing radiation
|
GO:0071479 |
32 |
0.081
|
|
|
|
circadian behavior
|
GO:0048512 |
2 |
0.081
|
|
|
|
astrocyte differentiation
|
GO:0048708 |
4 |
0.080
|
|
|
|
cell development
|
GO:0048468 |
328 |
0.079
|
|
|
|
response to growth factor
|
GO:0070848 |
205 |
0.079
|
|
|
|
establishment of protein localization to membrane
|
GO:0090150 |
121 |
0.078
|
|
|
|
reactive oxygen species metabolic process
|
GO:0072593 |
75 |
0.077
|
|
|
|
cellular protein catabolic process
|
GO:0044257 |
261 |
0.077
|
|
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
331 |
0.076
|
|
|
|
erk1 and erk2 cascade
|
GO:0070371 |
104 |
0.075
|
|
|
|
nucleoside catabolic process
|
GO:0009164 |
408 |
0.075
|
|
|
|
cellular response to external stimulus
|
GO:0071496 |
111 |
0.074
|
|
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.074
|
|
|
|
regulation of mitotic cell cycle
|
GO:0007346 |
189 |
0.073
|
|
|
|
negative regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043154 |
46 |
0.073
|
|
|
|
guanosine containing compound metabolic process
|
GO:1901068 |
244 |
0.073
|
|
|
|
glycerophospholipid metabolic process
|
GO:0006650 |
84 |
0.072
|
|
|
|
positive regulation of protein oligomerization
|
GO:0032461 |
17 |
0.072
|
|
|
|
regulation of reactive oxygen species metabolic process
|
GO:2000377 |
41 |
0.072
|
|
|
|
posttranscriptional regulation of gene expression
|
GO:0010608 |
213 |
0.072
|
|
|
|
circulatory system development
|
GO:0072359 |
262 |
0.072
|
|
|
|
negative regulation of apoptotic signaling pathway
|
GO:2001234 |
97 |
0.071
|
|
|
|
positive regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043280 |
69 |
0.071
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
183 |
0.071
|
|
|
|
post embryonic development
|
GO:0009791 |
2 |
0.070
|
|
|
|
protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
|
GO:0001844 |
2 |
0.069
|
|
|
|
regulation of cell motility
|
GO:2000145 |
299 |
0.069
|
|
|
|
regulation of intracellular transport
|
GO:0032386 |
195 |
0.069
|
|
|
|
defense response
|
GO:0006952 |
315 |
0.069
|
|
|
|
proteasome mediated ubiquitin dependent protein catabolic process
|
GO:0043161 |
156 |
0.068
|
|
|
|
cellular lipid metabolic process
|
GO:0044255 |
303 |
0.068
|
|
|
|
response to organic cyclic compound
|
GO:0014070 |
204 |
0.068
|
|
|
|
distal tubule development
|
GO:0072017 |
4 |
0.067
|
|
|
|
glycosyl compound catabolic process
|
GO:1901658 |
413 |
0.066
|
|
|
|
negative regulation of camp mediated signaling
|
GO:0043951 |
4 |
0.066
|
|
|
|
activation of mapkk activity
|
GO:0000186 |
18 |
0.065
|
|
|
|
nucleoside phosphate catabolic process
|
GO:1901292 |
412 |
0.065
|
|
|
|
positive regulation of intracellular transport
|
GO:0032388 |
104 |
0.065
|
|
|
|
positive regulation of reactive oxygen species metabolic process
|
GO:2000379 |
24 |
0.065
|
|
|
|
p38mapk cascade
|
GO:0038066 |
9 |
0.064
|
|
|
|
negative regulation of cellular component organization
|
GO:0051129 |
235 |
0.064
|
|
|
|
dna repair
|
GO:0006281 |
198 |
0.063
|
|
|
|
negative regulation of kinase activity
|
GO:0033673 |
106 |
0.063
|
Mouse |
|
|
cellular response to nitrogen compound
|
GO:1901699 |
144 |
0.063
|
|
|
|
negative regulation of transcription initiation from rna polymerase ii promoter
|
GO:0060633 |
3 |
0.061
|
|
|
|
positive regulation of transport
|
GO:0051050 |
336 |
0.061
|
|
|
|
ventral spinal cord development
|
GO:0021517 |
1 |
0.061
|
|
|
|
vesicle mediated transport
|
GO:0016192 |
371 |
0.060
|
|
|
|
aldehyde biosynthetic process
|
GO:0046184 |
3 |
0.060
|
|
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.060
|
|
|
|
system process
|
GO:0003008 |
349 |
0.059
|
|
|
|
negative regulation of cellular amine metabolic process
|
GO:0033239 |
3 |
0.059
|
|
|
|
heart morphogenesis
|
GO:0003007 |
48 |
0.059
|
|
|
|
peptidyl serine phosphorylation
|
GO:0018105 |
101 |
0.058
|
|
|
|
striated muscle tissue development
|
GO:0014706 |
59 |
0.058
|
|
|
|
cellular response to lithium ion
|
GO:0071285 |
2 |
0.057
|
|
|
|
innate immune response
|
GO:0045087 |
178 |
0.057
|
|
|
|
limbic system development
|
GO:0021761 |
3 |
0.057
|
|
|
|
oxidation reduction process
|
GO:0055114 |
396 |
0.057
|
|
|
|
peptidyl serine modification
|
GO:0018209 |
106 |
0.056
|
|
|
|
positive regulation of jnk cascade
|
GO:0046330 |
52 |
0.056
|
|
|
|
neural tube formation
|
GO:0001841 |
3 |
0.055
|
|
|
|
regulation of cell cycle phase transition
|
GO:1901987 |
126 |
0.055
|
|
|
|
spinal cord development
|
GO:0021510 |
4 |
0.055
|
|
|
|
regulation of i kappab kinase nf kappab signaling
|
GO:0043122 |
162 |
0.055
|
|
|
|
small molecule biosynthetic process
|
GO:0044283 |
157 |
0.054
|
|
|
|
somitogenesis
|
GO:0001756 |
2 |
0.054
|
|
|
|
segmentation
|
GO:0035282 |
4 |
0.054
|
|
|
|
regulation of mitotic cell cycle phase transition
|
GO:1901990 |
118 |
0.054
|
|
|
|
negative regulation of cysteine type endopeptidase activity
|
GO:2000117 |
48 |
0.054
|
|
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
411 |
0.053
|
|
|
|
regulation of intrinsic apoptotic signaling pathway
|
GO:2001242 |
72 |
0.053
|
|
|
|
response to metal ion
|
GO:0010038 |
84 |
0.053
|
|
|
|
rhythmic behavior
|
GO:0007622 |
2 |
0.053
|
|
|
|
regulation of calcium ion transport
|
GO:0051924 |
79 |
0.052
|
|
|
|
regulation of protein secretion
|
GO:0050708 |
86 |
0.052
|
|
|
|
negative regulation of sequence specific dna binding transcription factor activity
|
GO:0043433 |
89 |
0.051
|
|
|
|
single organism membrane organization
|
GO:0044802 |
268 |
0.051
|
|
|
|
keratinocyte differentiation
|
GO:0030216 |
36 |
0.050
|
|
|
|
regulation of cell development
|
GO:0060284 |
161 |
0.050
|
|
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
380 |
0.050
|
|
|
|
positive regulation of catabolic process
|
GO:0009896 |
310 |
0.049
|
|
|
|
negative regulation of epithelial cell proliferation
|
GO:0050680 |
48 |
0.049
|
|
|
|
positive regulation of gtp catabolic process
|
GO:0033126 |
166 |
0.049
|
|
|
|
syncytium formation by plasma membrane fusion
|
GO:0000768 |
2 |
0.048
|
|
|
|
cellular response to organic cyclic compound
|
GO:0071407 |
127 |
0.048
|
|
|
|
g1 s transition of mitotic cell cycle
|
GO:0000082 |
78 |
0.048
|
|
|
|
meiotic cell cycle
|
GO:0051321 |
13 |
0.048
|
|
|
|
positive regulation of peptidase activity
|
GO:0010952 |
88 |
0.047
|
|
|
|
regulation of nucleotide metabolic process
|
GO:0006140 |
269 |
0.047
|
|
|
|
response to inorganic substance
|
GO:0010035 |
127 |
0.046
|
|
|
|
protein oligomerization
|
GO:0051259 |
173 |
0.046
|
|
|
|
positive regulation of purine nucleotide metabolic process
|
GO:1900544 |
227 |
0.046
|
|
|
|
cell cycle g1 s phase transition
|
GO:0044843 |
80 |
0.046
|
|
|
|
chemotaxis
|
GO:0006935 |
157 |
0.046
|
|
|
|
response to bacterium
|
GO:0009617 |
144 |
0.046
|
|
|
|
protein insertion into mitochondrial membrane
|
GO:0051204 |
3 |
0.046
|
|
|
|
secretion by cell
|
GO:0032940 |
226 |
0.045
|
|
|
|
positive regulation of peptidyl threonine phosphorylation
|
GO:0010800 |
9 |
0.045
|
|
|
|
response to insulin
|
GO:0032868 |
45 |
0.045
|
|
|
|
negative regulation of chromosome organization
|
GO:2001251 |
48 |
0.045
|
|
|
|
rhythmic process
|
GO:0048511 |
31 |
0.045
|
|
|
|
internal peptidyl lysine acetylation
|
GO:0018393 |
97 |
0.044
|
|
|
|
single organism cellular localization
|
GO:1902580 |
332 |
0.044
|
|
|
|
organophosphate biosynthetic process
|
GO:0090407 |
163 |
0.044
|
|
|
|
response to vitamin d
|
GO:0033280 |
10 |
0.043
|
|
|
|
formaldehyde metabolic process
|
GO:0046292 |
1 |
0.043
|
|
|
|
compound eye development
|
GO:0048749 |
1 |
0.043
|
|
|
|
regulation of protein maturation
|
GO:1903317 |
150 |
0.043
|
|
|
|
activation of immune response
|
GO:0002253 |
114 |
0.043
|
|
|
|
negative regulation of secretion by cell
|
GO:1903531 |
52 |
0.043
|
|
|
|
dna damage response signal transduction by p53 class mediator
|
GO:0030330 |
44 |
0.043
|
|
|
|
ubiquitin dependent protein catabolic process
|
GO:0006511 |
206 |
0.042
|
|
|
|
lipid metabolic process
|
GO:0006629 |
381 |
0.042
|
|
|
|
developmental growth
|
GO:0048589 |
48 |
0.042
|
|
|
|
negative regulation of jun kinase activity
|
GO:0043508 |
4 |
0.041
|
|
|
|
protein modification by small protein conjugation
|
GO:0032446 |
342 |
0.041
|
|
|
|
cell fate determination
|
GO:0001709 |
3 |
0.040
|
|
|
|
central nervous system development
|
GO:0007417 |
123 |
0.040
|
|
|
|
muscle cell differentiation
|
GO:0042692 |
63 |
0.040
|
|
|
|
signal transduction by phosphorylation
|
GO:0023014 |
297 |
0.040
|
|
|
|
developmental programmed cell death
|
GO:0010623 |
3 |
0.040
|
|
|
|
blood vessel development
|
GO:0001568 |
172 |
0.040
|
|
|
|
myeloid cell differentiation
|
GO:0030099 |
117 |
0.039
|
|
|
|
mitotic cell cycle phase transition
|
GO:0044772 |
162 |
0.039
|
|
|
|
purine nucleoside triphosphate catabolic process
|
GO:0009146 |
392 |
0.039
|
|
|
|
regulation of protein transport
|
GO:0051223 |
213 |
0.039
|
|
|
|
negative regulation of hydrolase activity
|
GO:0051346 |
182 |
0.039
|
|
|
|
positive regulation of mapk cascade
|
GO:0043410 |
190 |
0.038
|
|
|
|
cellular component morphogenesis
|
GO:0032989 |
314 |
0.038
|
|
|
|
negative regulation of bile acid biosynthetic process
|
GO:0070858 |
3 |
0.038
|
|
|
|
positive regulation of cysteine type endopeptidase activity
|
GO:2001056 |
79 |
0.038
|
|
|
|
negative regulation of transport
|
GO:0051051 |
176 |
0.038
|
|
|
|
meiosis i
|
GO:0007127 |
4 |
0.038
|
|
|
|
regulation of cell growth
|
GO:0001558 |
135 |
0.037
|
|
|
|
positive regulation of cell cycle
|
GO:0045787 |
140 |
0.037
|
|
|
|
intracellular steroid hormone receptor signaling pathway
|
GO:0030518 |
61 |
0.037
|
|
|
|
negative regulation of cell motility
|
GO:2000146 |
104 |
0.037
|
|
|
|
negative regulation of organelle organization
|
GO:0010639 |
126 |
0.037
|
|
|
|
negative regulation of protein transport
|
GO:0051224 |
75 |
0.037
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
179 |
0.036
|
|
|
|
brain development
|
GO:0007420 |
97 |
0.036
|
|
|
|
calcium ion transport
|
GO:0006816 |
147 |
0.036
|
|
|
|
negative regulation of developmental process
|
GO:0051093 |
247 |
0.036
|
|
|
|
transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0007178 |
125 |
0.036
|
|
|
|
enzyme linked receptor protein signaling pathway
|
GO:0007167 |
303 |
0.036
|
|
|
|
regulation of nervous system development
|
GO:0051960 |
88 |
0.036
|
|
|
|
protein localization to organelle
|
GO:0033365 |
280 |
0.036
|
|
|
|
endothelial cell migration
|
GO:0043542 |
86 |
0.036
|
|
|
|
forebrain development
|
GO:0030900 |
26 |
0.035
|
|
|
|
positive regulation of immune system process
|
GO:0002684 |
283 |
0.035
|
|
|
|
translation
|
GO:0006412 |
132 |
0.035
|
|
|
|
protein localization to mitochondrion
|
GO:0070585 |
25 |
0.035
|
|
|
|
cellular response to insulin stimulus
|
GO:0032869 |
41 |
0.034
|
|
|
|
regulation of anatomical structure size
|
GO:0090066 |
101 |
0.034
|
|
|
|
membrane organization
|
GO:0061024 |
292 |
0.034
|
|
|
|
response to hyperoxia
|
GO:0055093 |
4 |
0.034
|
|
|
|
muscle tissue development
|
GO:0060537 |
62 |
0.034
|
|
|
|
regulation of nucleotide catabolic process
|
GO:0030811 |
205 |
0.034
|
|
|
|
meiotic chromosome segregation
|
GO:0045132 |
4 |
0.034
|
|
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
127 |
0.034
|
|
|
|
angiogenesis
|
GO:0001525 |
147 |
0.034
|
|
|
|
spermatid differentiation
|
GO:0048515 |
4 |
0.033
|
|
|
|
generation of neurons
|
GO:0048699 |
152 |
0.033
|
|
|
|
guanosine containing compound catabolic process
|
GO:1901069 |
239 |
0.033
|
|
|
|
cell cell signaling
|
GO:0007267 |
155 |
0.033
|
|
|
|
regulation of dna metabolic process
|
GO:0051052 |
153 |
0.033
|
|
|
|
embryonic epithelial tube formation
|
GO:0001838 |
4 |
0.033
|
|
|
|
regulation of synaptic plasticity
|
GO:0048167 |
3 |
0.033
|
|
|
|
regulation of growth
|
GO:0040008 |
165 |
0.033
|
|
|
|
positive regulation of gliogenesis
|
GO:0014015 |
4 |
0.033
|
|
|
|
negative regulation of secretion
|
GO:0051048 |
58 |
0.032
|
|
|
|
negative regulation of endopeptidase activity
|
GO:0010951 |
84 |
0.032
|
|
|
|
regulation of locomotion
|
GO:0040012 |
329 |
0.032
|
|
|
|
regulation of protein modification by small protein conjugation or removal
|
GO:1903320 |
107 |
0.032
|
|
|
|
photoreceptor cell differentiation
|
GO:0046530 |
2 |
0.032
|
|
|
|
cell morphogenesis
|
GO:0000902 |
296 |
0.032
|
|
|
|
positive regulation of endothelial cell migration
|
GO:0010595 |
39 |
0.032
|
|
|
|
response to salt stress
|
GO:0009651 |
3 |
0.032
|
|
|
|
growth
|
GO:0040007 |
202 |
0.031
|
|
|
|
de novo protein folding
|
GO:0006458 |
2 |
0.031
|
|
|
|
positive regulation of endopeptidase activity
|
GO:0010950 |
84 |
0.031
|
|
|
|
cellular response to steroid hormone stimulus
|
GO:0071383 |
37 |
0.031
|
|
|
|
extrinsic apoptotic signaling pathway
|
GO:0097191 |
119 |
0.031
|
|
|
|
meiotic nuclear division
|
GO:0007126 |
10 |
0.031
|
|
|
|
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
|
GO:1901028 |
9 |
0.031
|
|
|
|
cytoplasmic transport
|
GO:0016482 |
379 |
0.031
|
|
|
|
regulation of erk1 and erk2 cascade
|
GO:0070372 |
99 |
0.030
|
|
|
|
interspecies interaction between organisms
|
GO:0044419 |
156 |
0.030
|
|
|
|
maintenance of location
|
GO:0051235 |
112 |
0.030
|
|
|
|
endocardial cushion development
|
GO:0003197 |
3 |
0.030
|
|
|
|
cell activation
|
GO:0001775 |
213 |
0.030
|
|
|
|
cytokine secretion
|
GO:0050663 |
64 |
0.030
|
|
|
|
positive regulation of cell cycle process
|
GO:0090068 |
106 |
0.030
|
|
|
|
intermediate filament cytoskeleton organization
|
GO:0045104 |
17 |
0.030
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.030
|
|
|
|
mitotic nuclear division
|
GO:0007067 |
119 |
0.029
|
|
|
|
response to acid chemical
|
GO:0001101 |
66 |
0.029
|
|
|
|
response to cycloheximide
|
GO:0046898 |
1 |
0.029
|
|
|
|
negative regulation of cholesterol storage
|
GO:0010887 |
4 |
0.029
|
|
|
|
protein localization to membrane
|
GO:0072657 |
160 |
0.029
|
|
|
|
neuron differentiation
|
GO:0030182 |
138 |
0.029
|
|
|
|
glycerophospholipid biosynthetic process
|
GO:0046474 |
40 |
0.029
|
|
|
|
positive regulation of cell differentiation
|
GO:0045597 |
211 |
0.029
|
|
|
|
kidney development
|
GO:0001822 |
53 |
0.029
|
|
|
|
positive regulation of glial cell proliferation
|
GO:0060252 |
2 |
0.029
|
|
|
|
regulation of gtpase activity
|
GO:0043087 |
180 |
0.029
|
|
|
|
regulation of cell morphogenesis
|
GO:0022604 |
153 |
0.029
|
|
|
|
determination of adult lifespan
|
GO:0008340 |
2 |
0.029
|
|
|
|
morphogenesis of an epithelium
|
GO:0002009 |
60 |
0.028
|
|
|
|
hormone mediated signaling pathway
|
GO:0009755 |
22 |
0.028
|
|
|
|
regulation of cyclin dependent protein serine threonine kinase activity
|
GO:0000079 |
36 |
0.028
|
|
|
|
signal transduction by p53 class mediator
|
GO:0072331 |
72 |
0.028
|
|
|
|
response to radiation
|
GO:0009314 |
151 |
0.028
|
|
|
|
histone h3 k9 demethylation
|
GO:0033169 |
7 |
0.028
|
|
|
|
cellular response to interleukin 3
|
GO:0036016 |
1 |
0.028
|
|
|
|
immune response
|
GO:0006955 |
307 |
0.028
|
|
|
|
positive regulation of ras gtpase activity
|
GO:0032320 |
117 |
0.028
|
|
|
|
protein catabolic process
|
GO:0030163 |
325 |
0.028
|
|
|
|
striated muscle cell differentiation
|
GO:0051146 |
43 |
0.028
|
|
|
|
regulation of cell cycle g1 s phase transition
|
GO:1902806 |
42 |
0.028
|
|
|
|
regulation of cell activation
|
GO:0050865 |
125 |
0.028
|
|
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
244 |
0.028
|
|
|
|
cell substrate adhesion
|
GO:0031589 |
132 |
0.027
|
|
|
|
negative regulation of smoothened signaling pathway
|
GO:0045879 |
3 |
0.027
|
|
|
|
response to peptide
|
GO:1901652 |
65 |
0.027
|
|
|
|
positive regulation of cell migration
|
GO:0030335 |
172 |
0.027
|
|
|
|
mitotic g1 s transition checkpoint
|
GO:0044819 |
17 |
0.027
|
|
|
|
cytokine production
|
GO:0001816 |
247 |
0.027
|
|
|
|
response to virus
|
GO:0009615 |
126 |
0.027
|
|
|
|
glucose homeostasis
|
GO:0042593 |
31 |
0.027
|
|
|
|
response to steroid hormone
|
GO:0048545 |
80 |
0.027
|
|
|
|
dna biosynthetic process
|
GO:0071897 |
40 |
0.026
|
|
|
|
positive regulation of stress activated protein kinase signaling cascade
|
GO:0070304 |
61 |
0.026
|
|
|
|
regulation of organ morphogenesis
|
GO:2000027 |
24 |
0.026
|
|
|
|
regulation of cell proliferation involved in heart morphogenesis
|
GO:2000136 |
1 |
0.026
|
|
|
|
reproductive system development
|
GO:0061458 |
56 |
0.026
|
|
|
|
regulation of proteolysis involved in cellular protein catabolic process
|
GO:1903050 |
91 |
0.026
|
|
|
|
inorganic ion transmembrane transport
|
GO:0098660 |
231 |
0.026
|
|
|
|
golgi vesicle transport
|
GO:0048193 |
80 |
0.026
|
|
|
|
hexose metabolic process
|
GO:0019318 |
55 |
0.025
|
|
|
|
cardiovascular system development
|
GO:0072358 |
262 |
0.025
|
|
|
|
hippocampus development
|
GO:0021766 |
1 |
0.025
|
|
|
|
phospholipid biosynthetic process
|
GO:0008654 |
44 |
0.025
|
|
|
|
intracellular bile acid receptor signaling pathway
|
GO:0038185 |
1 |
0.025
|
|
|
|
cellular aldehyde metabolic process
|
GO:0006081 |
20 |
0.025
|
|
|
|
response to nitrogen compound
|
GO:1901698 |
184 |
0.025
|
|
|
|
histone modification
|
GO:0016570 |
251 |
0.025
|
|
|
|
regulation of meiosis
|
GO:0040020 |
3 |
0.025
|
|
|
|
positive regulation of protein serine threonine kinase activity
|
GO:0071902 |
119 |
0.025
|
|
|
|
positive regulation of gtpase activity
|
GO:0043547 |
166 |
0.024
|
|
|
|
immune system development
|
GO:0002520 |
195 |
0.024
|
|
|
|
negative regulation of erk1 and erk2 cascade
|
GO:0070373 |
14 |
0.024
|
|
|
|
cellular response to lipid
|
GO:0071396 |
127 |
0.024
|
|
|
|
positive regulation of nucleoside metabolic process
|
GO:0045979 |
186 |
0.024
|
|
|
|
negative regulation of growth
|
GO:0045926 |
97 |
0.024
|
|
|
|
divalent metal ion transport
|
GO:0070838 |
152 |
0.024
|
|
|
|
negative regulation of cell cycle process
|
GO:0010948 |
121 |
0.024
|
|
|
|
urogenital system development
|
GO:0001655 |
65 |
0.024
|
|
|
|
response to peptide hormone
|
GO:0043434 |
61 |
0.024
|
|
|
|
organophosphate catabolic process
|
GO:0046434 |
430 |
0.023
|
|
|
|
negative regulation of locomotion
|
GO:0040013 |
118 |
0.023
|
|
|
|
negative regulation of protein secretion
|
GO:0050709 |
29 |
0.023
|
|
|
|
positive regulation of leukocyte activation
|
GO:0002696 |
80 |
0.023
|
|
|
|
regulation of cellular component movement
|
GO:0051270 |
334 |
0.023
|
|
|
|
regulation of glial cell proliferation
|
GO:0060251 |
4 |
0.023
|
|
|
|
regulation of epidermal cell differentiation
|
GO:0045604 |
15 |
0.023
|
|
|
|
modification dependent protein catabolic process
|
GO:0019941 |
209 |
0.023
|
|
|
|
neuron projection regeneration
|
GO:0031102 |
1 |
0.023
|
|
|
|
cellular response to cytokine stimulus
|
GO:0071345 |
181 |
0.023
|
|
|
|
regulation of heart morphogenesis
|
GO:2000826 |
4 |
0.022
|
|
|
|
sodium ion transport
|
GO:0006814 |
61 |
0.022
|
|
|
|
dna replication
|
GO:0006260 |
116 |
0.022
|
|
|
|
regulation of protein complex assembly
|
GO:0043254 |
147 |
0.022
|
|
|
|
cellular response to organonitrogen compound
|
GO:0071417 |
124 |
0.022
|
|
|
|
organic acid biosynthetic process
|
GO:0016053 |
97 |
0.022
|
|
|
|
regulation of interleukin 8 production
|
GO:0032677 |
49 |
0.022
|
|
|
|
intrinsic apoptotic signaling pathway in response to dna damage
|
GO:0008630 |
50 |
0.022
|
|
|
|
metal ion transport
|
GO:0030001 |
272 |
0.022
|
|
|
|
positive regulation of protein catabolic process
|
GO:0045732 |
75 |
0.022
|
|
|
|
epithelial tube morphogenesis
|
GO:0060562 |
38 |
0.022
|
|
|
|
divalent inorganic cation transport
|
GO:0072511 |
158 |
0.022
|
|
|
|
nervous system development
|
GO:0007399 |
293 |
0.021
|
|
|
|
regulation of secretion
|
GO:0051046 |
194 |
0.021
|
|
|
|
regulation of body fluid levels
|
GO:0050878 |
99 |
0.021
|
|
|
|
skin development
|
GO:0043588 |
76 |
0.021
|
|
|
|
regulation of secretion by cell
|
GO:1903530 |
177 |
0.021
|
|
|
|
mitotic cell cycle checkpoint
|
GO:0007093 |
68 |
0.021
|
|
|
|
cellular carbohydrate metabolic process
|
GO:0044262 |
84 |
0.021
|
|
|
|
negative regulation of catabolic process
|
GO:0009895 |
104 |
0.021
|
|
|
|
microtubule based process
|
GO:0007017 |
210 |
0.021
|
Mouse |
|
|
response to estrogen
|
GO:0043627 |
47 |
0.021
|
|
|
|
regulation of purine nucleotide catabolic process
|
GO:0033121 |
205 |
0.021
|
|
|
|
wound healing
|
GO:0042060 |
115 |
0.021
|
|
|
|
morphogenesis of embryonic epithelium
|
GO:0016331 |
4 |
0.020
|
|
|
|
somatic stem cell maintenance
|
GO:0035019 |
4 |
0.020
|
|
|
|
cellular chemical homeostasis
|
GO:0055082 |
180 |
0.020
|
|
|
|
purine ribonucleoside triphosphate catabolic process
|
GO:0009207 |
391 |
0.020
|
|
|
|
regulation of keratinocyte proliferation
|
GO:0010837 |
11 |
0.020
|
|
|
|
ribonucleoside catabolic process
|
GO:0042454 |
406 |
0.020
|
|
|
|
phospholipid metabolic process
|
GO:0006644 |
99 |
0.020
|
|
|
|
monocarboxylic acid metabolic process
|
GO:0032787 |
185 |
0.020
|
|
|
|
internal protein amino acid acetylation
|
GO:0006475 |
101 |
0.020
|
|
|
|
cellular response to glucocorticoid stimulus
|
GO:0071385 |
4 |
0.020
|
|
|
|
positive regulation of axon extension
|
GO:0045773 |
4 |
0.020
|
|
|
|
positive regulation of dna metabolic process
|
GO:0051054 |
73 |
0.020
|
|
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
140 |
0.020
|
Mouse |
|
|
spermatid development
|
GO:0007286 |
4 |
0.020
|
|
|
|
regulation of lymphocyte proliferation
|
GO:0050670 |
64 |
0.020
|
|
|
|
tissue morphogenesis
|
GO:0048729 |
96 |
0.020
|
|
|
|
stress activated protein kinase signaling cascade
|
GO:0031098 |
94 |
0.020
|
|
|
|
cellular response to amino acid stimulus
|
GO:0071230 |
12 |
0.019
|
|
|
|
defense response to bacterium
|
GO:0042742 |
63 |
0.019
|
|
|
|
zymogen activation
|
GO:0031638 |
70 |
0.019
|
|
|
|
cell projection morphogenesis
|
GO:0048858 |
129 |
0.019
|
|
|
|
activation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0006919 |
49 |
0.019
|
|
|
|
small molecule catabolic process
|
GO:0044282 |
92 |
0.019
|
|
|
|
regulation of meiotic cell cycle
|
GO:0051445 |
4 |
0.019
|
|
|
|
myoblast fusion
|
GO:0007520 |
1 |
0.019
|
|
|
|
mitotic dna integrity checkpoint
|
GO:0044774 |
30 |
0.019
|
|
|
|
sister chromatid segregation
|
GO:0000819 |
54 |
0.019
|
|
|
|
regulation of vasculature development
|
GO:1901342 |
97 |
0.019
|
|
|
|
protein k48 linked ubiquitination
|
GO:0070936 |
38 |
0.019
|
|
|
|
secondary heart field specification
|
GO:0003139 |
2 |
0.019
|
|
|
|
cell projection organization
|
GO:0030030 |
252 |
0.019
|
|
|
|
negative regulation of dendrite development
|
GO:2000171 |
5 |
0.019
|
|
|
|
negative regulation of blood vessel morphogenesis
|
GO:2000181 |
41 |
0.019
|
|
|
|
chordate embryonic development
|
GO:0043009 |
34 |
0.019
|
|
|
|
muscle cell proliferation
|
GO:0033002 |
35 |
0.019
|
|
|
|
response to lipid
|
GO:0033993 |
206 |
0.018
|
|
|
|
protein secretion
|
GO:0009306 |
98 |
0.018
|
|
|
|
regulation of purine nucleotide metabolic process
|
GO:1900542 |
264 |
0.018
|
|
|
|
regulation of lymphocyte activation
|
GO:0051249 |
103 |
0.018
|
|
|
|
nitrogen compound transport
|
GO:0071705 |
191 |
0.018
|
|
|
|
negative regulation of cell cycle phase transition
|
GO:1901988 |
89 |
0.018
|
|
|
|
cell division
|
GO:0051301 |
168 |
0.018
|
|
|
|
peripheral nervous system development
|
GO:0007422 |
2 |
0.018
|
|
