|
|
regulation of ion transmembrane transport
|
GO:0034765 |
132 |
0.835
|
Human |
|
|
inorganic ion transmembrane transport
|
GO:0098660 |
231 |
0.782
|
Human Rat |
|
|
gtp catabolic process
|
GO:0006184 |
237 |
0.782
|
Human Yeast |
|
|
actin filament based process
|
GO:0030029 |
224 |
0.743
|
Fly |
|
|
ion transmembrane transport
|
GO:0034220 |
338 |
0.677
|
Human Rat |
|
|
purine ribonucleotide catabolic process
|
GO:0009154 |
404 |
0.566
|
Human Yeast |
|
|
regulation of transmembrane transport
|
GO:0034762 |
139 |
0.563
|
Human |
|
|
inorganic cation transmembrane transport
|
GO:0098662 |
194 |
0.526
|
Human Rat |
|
|
nucleotide catabolic process
|
GO:0009166 |
408 |
0.483
|
Human Yeast |
|
|
mitotic cell cycle
|
GO:0000278 |
326 |
0.466
|
Worm |
|
|
nucleus localization
|
GO:0051647 |
1 |
0.464
|
Worm |
|
|
purine ribonucleoside catabolic process
|
GO:0046130 |
398 |
0.454
|
Human Yeast |
|
|
regulation of ion transport
|
GO:0043269 |
189 |
0.420
|
Human |
|
|
positive regulation of secretion by cell
|
GO:1903532 |
108 |
0.416
|
|
|
|
ribonucleotide catabolic process
|
GO:0009261 |
405 |
0.416
|
Human Yeast |
|
|
negative regulation of cation channel activity
|
GO:2001258 |
12 |
0.407
|
Human |
|
|
gtp metabolic process
|
GO:0046039 |
239 |
0.390
|
Human Yeast |
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
411 |
0.373
|
Human Yeast |
|
|
endomembrane system organization
|
GO:0010256 |
196 |
0.370
|
|
|
|
canonical wnt signaling pathway
|
GO:0060070 |
116 |
0.365
|
|
|
|
single organism cellular localization
|
GO:1902580 |
332 |
0.365
|
Worm |
|
|
secretion
|
GO:0046903 |
254 |
0.363
|
|
|
|
mitotic cell cycle process
|
GO:1903047 |
286 |
0.357
|
Worm |
|
|
secretion by cell
|
GO:0032940 |
226 |
0.352
|
|
|
|
purine nucleoside catabolic process
|
GO:0006152 |
398 |
0.349
|
Human Yeast |
|
|
post embryonic development
|
GO:0009791 |
2 |
0.343
|
|
|
|
single organism membrane organization
|
GO:0044802 |
268 |
0.318
|
|
|
|
regulation of voltage gated calcium channel activity
|
GO:1901385 |
7 |
0.317
|
Human |
|
|
purine nucleoside triphosphate catabolic process
|
GO:0009146 |
392 |
0.312
|
Human Yeast |
|
|
regulation of cell communication by electrical coupling
|
GO:0010649 |
3 |
0.292
|
|
|
|
organophosphate catabolic process
|
GO:0046434 |
430 |
0.290
|
Human Yeast |
|
|
regulation of cell motility
|
GO:2000145 |
299 |
0.283
|
|
|
|
calcium ion transport
|
GO:0006816 |
147 |
0.282
|
Human Rat |
|
|
nitrogen compound transport
|
GO:0071705 |
191 |
0.277
|
|
|
|
ras protein signal transduction
|
GO:0007265 |
73 |
0.272
|
|
|
|
purine containing compound catabolic process
|
GO:0072523 |
411 |
0.271
|
Human Yeast |
|
|
cell projection assembly
|
GO:0030031 |
126 |
0.263
|
|
|
|
vesicle mediated transport
|
GO:0016192 |
371 |
0.261
|
|
|
|
regulation of cell cycle
|
GO:0051726 |
393 |
0.259
|
|
|
|
actin cytoskeleton organization
|
GO:0030036 |
207 |
0.255
|
Fly |
|
|
positive regulation of transport
|
GO:0051050 |
336 |
0.255
|
|
|
|
positive regulation of actin filament polymerization
|
GO:0030838 |
38 |
0.236
|
|
|
|
positive regulation of cell death
|
GO:0010942 |
263 |
0.233
|
|
|
|
actin filament polymerization
|
GO:0030041 |
45 |
0.231
|
|
|
|
guanosine containing compound catabolic process
|
GO:1901069 |
239 |
0.228
|
Human Yeast |
|
|
stem cell division
|
GO:0017145 |
2 |
0.227
|
Fly |
|
|
cell adhesion
|
GO:0007155 |
325 |
0.226
|
Fly |
|
|
transposition rna mediated
|
GO:0032197 |
0 |
0.223
|
Yeast |
|
|
ribonucleoside catabolic process
|
GO:0042454 |
406 |
0.223
|
Human Yeast |
|
|
circulatory system development
|
GO:0072359 |
262 |
0.222
|
Fly |
|
|
regulation of cellular component size
|
GO:0032535 |
82 |
0.214
|
|
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
313 |
0.213
|
|
|
|
purine ribonucleoside metabolic process
|
GO:0046128 |
437 |
0.213
|
Human Yeast |
|
|
regulation of transporter activity
|
GO:0032409 |
82 |
0.212
|
Human |
|
|
regulation of anatomical structure size
|
GO:0090066 |
101 |
0.210
|
|
|
|
transmembrane transport
|
GO:0055085 |
399 |
0.210
|
Human Rat |
|
|
cation transport
|
GO:0006812 |
331 |
0.208
|
Human Rat |
|
|
cell communication by electrical coupling involved in cardiac conduction
|
GO:0086064 |
3 |
0.196
|
|
|
|
regulation of cellular component biogenesis
|
GO:0044087 |
281 |
0.188
|
|
|
|
small gtpase mediated signal transduction
|
GO:0007264 |
78 |
0.188
|
|
|
|
regulation of gtp catabolic process
|
GO:0033124 |
180 |
0.187
|
Yeast |
|
|
cellular response to endogenous stimulus
|
GO:0071495 |
336 |
0.187
|
|
|
|
negative regulation of ion transmembrane transport
|
GO:0034766 |
26 |
0.186
|
Human |
|
|
nucleoside catabolic process
|
GO:0009164 |
408 |
0.181
|
Human Yeast |
|
|
purine nucleotide catabolic process
|
GO:0006195 |
405 |
0.179
|
Human Yeast |
|
|
response to abiotic stimulus
|
GO:0009628 |
336 |
0.178
|
|
|
|
regulation of relaxation of muscle
|
GO:1901077 |
3 |
0.177
|
|
|
|
actin filament organization
|
GO:0007015 |
128 |
0.177
|
Fly |
|
|
negative regulation of calcium ion transmembrane transporter activity
|
GO:1901020 |
11 |
0.175
|
Human |
|
|
regulation of cellular component movement
|
GO:0051270 |
334 |
0.173
|
|
|
|
cation transmembrane transport
|
GO:0098655 |
238 |
0.169
|
Human Rat |
|
|
purine nucleoside triphosphate metabolic process
|
GO:0009144 |
412 |
0.167
|
Human Yeast |
|
|
signal release
|
GO:0023061 |
70 |
0.165
|
|
|
|
regulation of rubidium ion transmembrane transporter activity
|
GO:2000686 |
2 |
0.163
|
|
|
|
embryo development
|
GO:0009790 |
123 |
0.163
|
Worm |
|
|
negative regulation of protein modification process
|
GO:0031400 |
200 |
0.163
|
|
|
|
regulation of canonical wnt signaling pathway
|
GO:0060828 |
88 |
0.157
|
|
|
|
nucleoside triphosphate metabolic process
|
GO:0009141 |
422 |
0.155
|
Human Yeast |
|
|
microtubule based process
|
GO:0007017 |
210 |
0.154
|
Worm |
|
|
glycosyl compound catabolic process
|
GO:1901658 |
413 |
0.153
|
Human Yeast |
|
|
cardiac muscle cell contraction
|
GO:0086003 |
4 |
0.152
|
|
|
|
regulation of actin filament based process
|
GO:0032970 |
141 |
0.148
|
|
|
|
positive regulation of gtpase activity
|
GO:0043547 |
166 |
0.148
|
|
|
|
neuroblast division
|
GO:0055057 |
1 |
0.146
|
Fly |
|
|
positive regulation of necrotic cell death
|
GO:0010940 |
4 |
0.144
|
|
|
|
regulation of homeostatic process
|
GO:0032844 |
121 |
0.142
|
|
|
|
regulation of metal ion transport
|
GO:0010959 |
120 |
0.141
|
Human |
|
|
regulation of anatomical structure morphogenesis
|
GO:0022603 |
286 |
0.137
|
|
|
|
negative regulation of transport
|
GO:0051051 |
176 |
0.136
|
Human |
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
267 |
0.134
|
|
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.131
|
|
|
|
cell projection organization
|
GO:0030030 |
252 |
0.128
|
|
|
|
nucleoside triphosphate catabolic process
|
GO:0009143 |
394 |
0.125
|
Human Yeast |
|
|
protein polymerization
|
GO:0051258 |
71 |
0.125
|
|
|
|
regulation of hormone secretion
|
GO:0046883 |
57 |
0.124
|
|
|
|
somatic stem cell division
|
GO:0048103 |
1 |
0.123
|
Fly |
|
|
regulation of actin filament polymerization
|
GO:0030833 |
50 |
0.122
|
|
|
|
regulation of ion transmembrane transporter activity
|
GO:0032412 |
72 |
0.121
|
Human |
|
|
hormone secretion
|
GO:0046879 |
65 |
0.119
|
|
|
|
biological adhesion
|
GO:0022610 |
331 |
0.119
|
Fly |
|
|
epithelium development
|
GO:0060429 |
227 |
0.118
|
|
|
|
cellular chemical homeostasis
|
GO:0055082 |
180 |
0.115
|
|
|
|
cellular protein complex disassembly
|
GO:0043624 |
36 |
0.114
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
7 |
0.113
|
|
|
|
cell division
|
GO:0051301 |
168 |
0.113
|
Fly |
|
|
wnt signaling pathway
|
GO:0016055 |
156 |
0.112
|
|
|
|
cell communication by electrical coupling
|
GO:0010644 |
5 |
0.112
|
|
|
|
regulation of secretion by cell
|
GO:1903530 |
177 |
0.111
|
|
|
|
regulation of calcium ion transport
|
GO:0051924 |
79 |
0.108
|
Human |
|
|
positive regulation of cellular component organization
|
GO:0051130 |
376 |
0.106
|
|
|
|
carbohydrate derivative biosynthetic process
|
GO:1901137 |
207 |
0.105
|
|
|
|
positive regulation of cell cycle
|
GO:0045787 |
140 |
0.105
|
|
|
|
regulation of locomotion
|
GO:0040012 |
329 |
0.105
|
Worm |
|
|
guanosine containing compound metabolic process
|
GO:1901068 |
244 |
0.104
|
Human Yeast |
|
|
negative regulation of phosphorylation
|
GO:0042326 |
174 |
0.104
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
289 |
0.104
|
|
|
|
vesicle organization
|
GO:0016050 |
62 |
0.104
|
|
|
|
nervous system development
|
GO:0007399 |
293 |
0.103
|
Human Fly |
|
|
mapk cascade
|
GO:0000165 |
288 |
0.102
|
|
|
|
multicellular organismal signaling
|
GO:0035637 |
34 |
0.100
|
|
|
|
regulation of ras gtpase activity
|
GO:0032318 |
128 |
0.098
|
|
|
|
regulation of cell migration
|
GO:0030334 |
289 |
0.095
|
|
|
|
regulation of actin polymerization or depolymerization
|
GO:0008064 |
56 |
0.095
|
|
|
|
organelle localization
|
GO:0051640 |
84 |
0.093
|
Worm |
|
|
amide transport
|
GO:0042886 |
76 |
0.092
|
|
|
|
membrane organization
|
GO:0061024 |
292 |
0.092
|
|
|
|
divalent inorganic cation transport
|
GO:0072511 |
158 |
0.091
|
Human Rat |
|
|
posttranscriptional regulation of gene expression
|
GO:0010608 |
213 |
0.091
|
|
|
|
regulation of gtpase activity
|
GO:0043087 |
180 |
0.090
|
Yeast |
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.090
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.088
|
|
|
|
cell cell junction organization
|
GO:0045216 |
69 |
0.088
|
|
|
|
regulation of high voltage gated calcium channel activity
|
GO:1901841 |
1 |
0.086
|
|
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.086
|
|
|
|
purine ribonucleoside triphosphate catabolic process
|
GO:0009207 |
391 |
0.085
|
Human Yeast |
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
380 |
0.085
|
|
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.085
|
|
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
190 |
0.083
|
|
|
|
i kappab kinase nf kappab signaling
|
GO:0007249 |
166 |
0.082
|
|
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.080
|
|
|
|
regulation of cytoskeleton organization
|
GO:0051493 |
177 |
0.078
|
|
|
|
regulation of cell morphogenesis
|
GO:0022604 |
153 |
0.076
|
|
|
|
positive regulation of cellular component biogenesis
|
GO:0044089 |
158 |
0.075
|
|
|
|
regulation of mapk cascade
|
GO:0043408 |
262 |
0.075
|
|
|
|
response to hormone
|
GO:0009725 |
175 |
0.075
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.073
|
|
|
|
regulation of cellular response to stress
|
GO:0080135 |
244 |
0.070
|
|
|
|
regulation of small gtpase mediated signal transduction
|
GO:0051056 |
156 |
0.069
|
|
|
|
chemical homeostasis
|
GO:0048878 |
306 |
0.069
|
|
|
|
nuclear import
|
GO:0051170 |
106 |
0.069
|
|
|
|
anterograde axon cargo transport
|
GO:0008089 |
1 |
0.069
|
|
|
|
reproduction
|
GO:0000003 |
63 |
0.068
|
Yeast Worm |
|
|
purine nucleoside monophosphate catabolic process
|
GO:0009128 |
158 |
0.067
|
|
|
|
protein import into nucleus
|
GO:0006606 |
104 |
0.066
|
|
|
|
anatomical structure formation involved in morphogenesis
|
GO:0048646 |
284 |
0.066
|
|
|
|
regulation of erk1 and erk2 cascade
|
GO:0070372 |
99 |
0.065
|
|
|
|
protein targeting
|
GO:0006605 |
187 |
0.065
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.064
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
80 |
0.064
|
|
|
|
ribonucleoside triphosphate metabolic process
|
GO:0009199 |
412 |
0.063
|
Human Yeast |
|
|
endocytosis
|
GO:0006897 |
159 |
0.061
|
|
|
|
positive regulation of cellular catabolic process
|
GO:0031331 |
284 |
0.060
|
|
|
|
establishment of protein localization to membrane
|
GO:0090150 |
121 |
0.060
|
|
|
|
microtubule cytoskeleton organization
|
GO:0000226 |
176 |
0.060
|
Worm |
|
|
cell cycle arrest
|
GO:0007050 |
71 |
0.059
|
|
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.059
|
|
|
|
cardiovascular system development
|
GO:0072358 |
262 |
0.058
|
Fly |
|
|
cell cell signaling
|
GO:0007267 |
155 |
0.058
|
|
|
|
cellular response to hormone stimulus
|
GO:0032870 |
125 |
0.058
|
|
|
|
regulation of actin filament length
|
GO:0030832 |
56 |
0.058
|
|
|
|
nuclear transport
|
GO:0051169 |
179 |
0.058
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
11 |
0.058
|
|
|
|
glycoprotein metabolic process
|
GO:0009100 |
110 |
0.058
|
|
|
|
golgi vesicle transport
|
GO:0048193 |
80 |
0.057
|
|
|
|
response to oxygen containing compound
|
GO:1901700 |
369 |
0.057
|
|
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.057
|
|
|
|
protein localization to organelle
|
GO:0033365 |
280 |
0.056
|
|
|
|
regulation of wnt signaling pathway
|
GO:0030111 |
123 |
0.056
|
|
|
|
cell fate determination
|
GO:0001709 |
3 |
0.055
|
|
|
|
response to decreased oxygen levels
|
GO:0036293 |
96 |
0.054
|
|
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
140 |
0.054
|
|
|
|
protein targeting to nucleus
|
GO:0044744 |
104 |
0.054
|
|
|
|
positive regulation of nucleotide metabolic process
|
GO:0045981 |
230 |
0.052
|
|
|
|
cyclic purine nucleotide metabolic process
|
GO:0052652 |
60 |
0.052
|
|
|
|
ion homeostasis
|
GO:0050801 |
230 |
0.052
|
|
|
|
regulation of establishment of protein localization
|
GO:0070201 |
242 |
0.052
|
|
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.052
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.051
|
|
|
|
determination of adult lifespan
|
GO:0008340 |
2 |
0.051
|
|
|
|
negative regulation of multicellular organismal process
|
GO:0051241 |
317 |
0.050
|
|
|
|
regulation of cell projection organization
|
GO:0031344 |
107 |
0.050
|
|
|
|
negative regulation of organelle organization
|
GO:0010639 |
126 |
0.050
|
|
|
|
regulation of actin cytoskeleton organization
|
GO:0032956 |
116 |
0.050
|
|
|
|
myosin filament organization
|
GO:0031033 |
2 |
0.049
|
|
|
|
divalent metal ion transport
|
GO:0070838 |
152 |
0.049
|
Human Rat |
|
|
actin polymerization or depolymerization
|
GO:0008154 |
56 |
0.049
|
|
|
|
nucleoside phosphate catabolic process
|
GO:1901292 |
412 |
0.049
|
Human Yeast |
|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.049
|
|
|
|
cytoplasmic transport
|
GO:0016482 |
379 |
0.048
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
179 |
0.048
|
|
|
|
plasma membrane organization
|
GO:0007009 |
115 |
0.048
|
|
|
|
cellular protein catabolic process
|
GO:0044257 |
261 |
0.048
|
|
|
|
response to calcium ion
|
GO:0051592 |
46 |
0.048
|
|
|
|
muscle structure development
|
GO:0061061 |
98 |
0.048
|
|
|
|
neuron differentiation
|
GO:0030182 |
138 |
0.048
|
|
|
|
cellular response to external stimulus
|
GO:0071496 |
111 |
0.047
|
|
|
|
blood vessel endothelial cell migration
|
GO:0043534 |
42 |
0.047
|
|
|
|
positive regulation of transporter activity
|
GO:0032411 |
32 |
0.047
|
|
|
|
female gamete generation
|
GO:0007292 |
2 |
0.047
|
|
|
|
cation homeostasis
|
GO:0055080 |
189 |
0.046
|
|
|
|
response to hypoxia
|
GO:0001666 |
96 |
0.046
|
|
|
|
protein autophosphorylation
|
GO:0046777 |
123 |
0.046
|
|
|
|
organelle assembly
|
GO:0070925 |
176 |
0.046
|
|
|
|
organelle fission
|
GO:0048285 |
149 |
0.046
|
|
|
|
behavior
|
GO:0007610 |
112 |
0.046
|
Worm |
|
|
regulation of nucleotide catabolic process
|
GO:0030811 |
205 |
0.045
|
Yeast |
|
|
exocytosis
|
GO:0006887 |
71 |
0.045
|
|
|
|
positive regulation of cell differentiation
|
GO:0045597 |
211 |
0.044
|
|
|
|
regulation of secretion
|
GO:0051046 |
194 |
0.044
|
|
|
|
negative regulation of blood circulation
|
GO:1903523 |
4 |
0.044
|
|
|
|
chromosome segregation
|
GO:0007059 |
114 |
0.044
|
|
|
|
regulation of system process
|
GO:0044057 |
101 |
0.042
|
|
|
|
establishment of nucleus localization
|
GO:0040023 |
1 |
0.042
|
Worm |
|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
181 |
0.042
|
|
|
|
ribonucleoside triphosphate catabolic process
|
GO:0009203 |
391 |
0.041
|
Human Yeast |
|
|
protein localization to membrane
|
GO:0072657 |
160 |
0.041
|
|
|
|
regulation of cell projection assembly
|
GO:0060491 |
47 |
0.040
|
|
|
|
peripheral nervous system development
|
GO:0007422 |
2 |
0.040
|
|
|
|
regulation of ras protein signal transduction
|
GO:0046578 |
155 |
0.040
|
|
|
|
blood vessel morphogenesis
|
GO:0048514 |
162 |
0.040
|
|
|
|
signal transduction by phosphorylation
|
GO:0023014 |
297 |
0.039
|
|
|
|
regulation of purine nucleotide metabolic process
|
GO:1900542 |
264 |
0.039
|
Yeast |
|
|
cellular response to oxygen containing compound
|
GO:1901701 |
276 |
0.039
|
|
|
|
positive regulation of purine nucleotide catabolic process
|
GO:0033123 |
185 |
0.039
|
|
|
|
homotypic cell cell adhesion
|
GO:0034109 |
47 |
0.038
|
|
|
|
cellular response to peptide hormone stimulus
|
GO:0071375 |
56 |
0.038
|
|
|
|
erk1 and erk2 cascade
|
GO:0070371 |
104 |
0.038
|
|
|
|
myosin filament assembly
|
GO:0031034 |
2 |
0.038
|
|
|
|
cell cycle phase transition
|
GO:0044770 |
173 |
0.038
|
|
|
|
negative regulation of transmembrane transport
|
GO:0034763 |
29 |
0.038
|
Human |
|
|
cellular response to abiotic stimulus
|
GO:0071214 |
117 |
0.038
|
|
|
|
cell part morphogenesis
|
GO:0032990 |
137 |
0.038
|
|
|
|
negative regulation of cellular amine metabolic process
|
GO:0033239 |
3 |
0.038
|
|
|
|
mitotic nuclear division
|
GO:0007067 |
119 |
0.038
|
|
|
|
establishment of protein localization to organelle
|
GO:0072594 |
172 |
0.037
|
|
|
|
peptidyl threonine modification
|
GO:0018210 |
45 |
0.037
|
|
|
|
protein localization to plasma membrane
|
GO:0072659 |
93 |
0.037
|
|
|
|
negative regulation of heart rate
|
GO:0010459 |
2 |
0.037
|
|
|
|
organonitrogen compound biosynthetic process
|
GO:1901566 |
200 |
0.036
|
|
|
|
cellular response to insulin stimulus
|
GO:0032869 |
41 |
0.036
|
|
|
|
protein catabolic process
|
GO:0030163 |
325 |
0.035
|
|
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
331 |
0.035
|
|
|
|
regulation of transmembrane transporter activity
|
GO:0022898 |
74 |
0.035
|
Human |
|
|
insulin secretion
|
GO:0030073 |
39 |
0.035
|
|
|
|
negative regulation of transferase activity
|
GO:0051348 |
124 |
0.034
|
|
|
|
pattern specification process
|
GO:0007389 |
43 |
0.034
|
|
|
|
regulation of epithelial cell migration
|
GO:0010632 |
93 |
0.034
|
|
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
391 |
0.034
|
|
|
|
blood vessel development
|
GO:0001568 |
172 |
0.034
|
|
|
|
calcium ion transmembrane transport
|
GO:0070588 |
76 |
0.034
|
Human Rat |
|
|
regulation of endocytosis
|
GO:0030100 |
72 |
0.034
|
|
|
|
second messenger mediated signaling
|
GO:0019932 |
78 |
0.033
|
|
|
|
regulation of proteolysis involved in cellular protein catabolic process
|
GO:1903050 |
91 |
0.033
|
|
|
|
constitutive secretory pathway
|
GO:0045054 |
3 |
0.033
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
41 |
0.033
|
|
|
|
intracellular protein transport
|
GO:0006886 |
270 |
0.032
|
|
|
|
sex differentiation
|
GO:0007548 |
45 |
0.032
|
|
|
|
positive regulation of gtp catabolic process
|
GO:0033126 |
166 |
0.032
|
|
|
|
metal ion transport
|
GO:0030001 |
272 |
0.032
|
Human Rat |
|
|
positive regulation of programmed cell death
|
GO:0043068 |
249 |
0.032
|
|
|
|
regulation of cell differentiation
|
GO:0045595 |
393 |
0.032
|
|
|
|
lymphocyte homeostasis
|
GO:0002260 |
4 |
0.031
|
|
|
|
regulation of protein complex assembly
|
GO:0043254 |
147 |
0.031
|
|
|
|
wound healing
|
GO:0042060 |
115 |
0.031
|
|
|
|
response to peptide
|
GO:1901652 |
65 |
0.031
|
|
|
|
regulation of vesicle mediated transport
|
GO:0060627 |
130 |
0.031
|
|
|
|
regulation of map kinase activity
|
GO:0043405 |
108 |
0.031
|
|
|
|
cellular lipid metabolic process
|
GO:0044255 |
303 |
0.031
|
|
|
|
regulation of blood circulation
|
GO:1903522 |
59 |
0.030
|
|
|
|
regulation of mitotic cell cycle
|
GO:0007346 |
189 |
0.030
|
|
|
|
regulation of protein polymerization
|
GO:0032271 |
63 |
0.030
|
|
|
|
protein stabilization
|
GO:0050821 |
64 |
0.030
|
|
|
|
regulation of nucleoside metabolic process
|
GO:0009118 |
209 |
0.030
|
Yeast |
|
|
positive regulation of cytoplasmic transport
|
GO:1903651 |
82 |
0.030
|
|
|
|
rac protein signal transduction
|
GO:0016601 |
12 |
0.030
|
|
|
|
regulation of proteasomal ubiquitin dependent protein catabolic process
|
GO:0032434 |
71 |
0.030
|
|
|
|
positive regulation of protein complex assembly
|
GO:0031334 |
86 |
0.030
|
|
|
|
relaxation of muscle
|
GO:0090075 |
7 |
0.030
|
|
|
|
cellular macromolecular complex assembly
|
GO:0034622 |
324 |
0.030
|
|
|
|
rho protein signal transduction
|
GO:0007266 |
26 |
0.029
|
|
|
|
regulation of muscle contraction
|
GO:0006937 |
45 |
0.029
|
|
|
|
negative regulation of transporter activity
|
GO:0032410 |
25 |
0.029
|
Human |
|
|
midbrain development
|
GO:0030901 |
45 |
0.029
|
Human |
|
|
establishment of protein localization to plasma membrane
|
GO:0090002 |
68 |
0.029
|
|
|
|
nucleoside phosphate biosynthetic process
|
GO:1901293 |
109 |
0.029
|
|
|
|
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger
|
GO:0007187 |
43 |
0.029
|
|
|
|
regulation of peptide transport
|
GO:0090087 |
62 |
0.029
|
|
|
|
cellular component morphogenesis
|
GO:0032989 |
314 |
0.029
|
|
|
|
regulation of cell cycle process
|
GO:0010564 |
266 |
0.029
|
|
|
|
protein glycosylation
|
GO:0006486 |
62 |
0.029
|
|
|
|
positive regulation of cell proliferation
|
GO:0008284 |
301 |
0.028
|
|
|
|
regulation of reactive oxygen species metabolic process
|
GO:2000377 |
41 |
0.028
|
|
|
|
endothelial cell migration
|
GO:0043542 |
86 |
0.028
|
|
|
|
reproductive process
|
GO:0022414 |
106 |
0.028
|
Yeast Worm |
|
|
regulation of cytoplasmic transport
|
GO:1903649 |
149 |
0.028
|
|
|
|
positive regulation of ras gtpase activity
|
GO:0032320 |
117 |
0.028
|
|
|
|
ubiquitin dependent protein catabolic process
|
GO:0006511 |
206 |
0.028
|
|
|
|
positive regulation of apoptotic process
|
GO:0043065 |
246 |
0.028
|
|
|
|
positive regulation of cyclic nucleotide biosynthetic process
|
GO:0030804 |
38 |
0.028
|
|
|
|
adenylate cyclase activating adrenergic receptor signaling pathway
|
GO:0071880 |
3 |
0.027
|
|
|
|
generation of neurons
|
GO:0048699 |
152 |
0.027
|
Fly |
|
|
single organism carbohydrate metabolic process
|
GO:0044723 |
193 |
0.027
|
|
|
|
defense response
|
GO:0006952 |
315 |
0.027
|
|
|
|
positive regulation of lipase activity
|
GO:0060193 |
28 |
0.027
|
|
|
|
negative regulation of heart contraction
|
GO:0045822 |
3 |
0.027
|
|
|
|
protein maturation
|
GO:0051604 |
233 |
0.027
|
|
|
|
negative regulation of cellular component organization
|
GO:0051129 |
235 |
0.027
|
|
|
|
ossification
|
GO:0001503 |
121 |
0.027
|
|
|
|
positive regulation of mapk cascade
|
GO:0043410 |
190 |
0.027
|
|
|
|
modification dependent protein catabolic process
|
GO:0019941 |
209 |
0.027
|
|
|
|
negative regulation of kinase activity
|
GO:0033673 |
106 |
0.027
|
|
|
|
lipid localization
|
GO:0010876 |
106 |
0.026
|
|
|
|
phosphatidic acid biosynthetic process
|
GO:0006654 |
4 |
0.026
|
|
|
|
cellular cation homeostasis
|
GO:0030003 |
163 |
0.026
|
|
|
|
cell activation
|
GO:0001775 |
213 |
0.026
|
|
|
|
epithelial cell migration
|
GO:0010631 |
119 |
0.026
|
|
|
|
negative regulation of protein modification by small protein conjugation or removal
|
GO:1903321 |
41 |
0.026
|
|
|
|
g protein coupled receptor signaling pathway
|
GO:0007186 |
207 |
0.025
|
Yeast |
|
|
positive regulation of protein polymerization
|
GO:0032273 |
45 |
0.025
|
|
|
|
cell substrate adherens junction assembly
|
GO:0007045 |
30 |
0.025
|
|
|
|
negative regulation of cell cycle
|
GO:0045786 |
193 |
0.025
|
|
|
|
negative regulation of hydrolase activity
|
GO:0051346 |
182 |
0.025
|
|
|
|
peptidyl threonine phosphorylation
|
GO:0018107 |
41 |
0.025
|
|
|
|
regulation of insulin secretion
|
GO:0050796 |
33 |
0.025
|
|
|
|
cellular response to organonitrogen compound
|
GO:0071417 |
124 |
0.025
|
|
|
|
cellular response to peptide
|
GO:1901653 |
59 |
0.025
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
183 |
0.025
|
|
|
|
multicellular organism reproduction
|
GO:0032504 |
42 |
0.025
|
Worm |
|
|
reactive oxygen species metabolic process
|
GO:0072593 |
75 |
0.025
|
|
|
|
regulation of actin filament based movement
|
GO:1903115 |
24 |
0.025
|
|
|
|
cellular protein complex assembly
|
GO:0043623 |
188 |
0.024
|
|
|
|
cellular component disassembly
|
GO:0022411 |
92 |
0.024
|
|
|
|
negative regulation of ion transport
|
GO:0043271 |
39 |
0.024
|
Human |
|
|
ruffle organization
|
GO:0031529 |
18 |
0.024
|
|
|
|
organophosphate biosynthetic process
|
GO:0090407 |
163 |
0.024
|
|
|
|
regulation of exocytosis
|
GO:0017157 |
46 |
0.024
|
|
|
|
glycoprotein biosynthetic process
|
GO:0009101 |
91 |
0.024
|
|
|
|
locomotory behavior
|
GO:0007626 |
1 |
0.024
|
|
|
|
eye development
|
GO:0001654 |
42 |
0.024
|
|
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
379 |
0.024
|
|
|
|
peptide secretion
|
GO:0002790 |
51 |
0.024
|
|
|
|
skin development
|
GO:0043588 |
76 |
0.023
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
204 |
0.023
|
|
|
|
response to nitrogen compound
|
GO:1901698 |
184 |
0.023
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
6 |
0.023
|
|
|
|
receptor metabolic process
|
GO:0043112 |
81 |
0.023
|
|
|
|
regulation of cation channel activity
|
GO:2001257 |
33 |
0.023
|
Human |
|
|
response to biotic stimulus
|
GO:0009607 |
276 |
0.022
|
|
|
|
regulation of meiotic cell cycle
|
GO:0051445 |
4 |
0.022
|
|
|
|
circulatory system process
|
GO:0003013 |
113 |
0.022
|
|
|
|
positive regulation of transferase activity
|
GO:0051347 |
227 |
0.022
|
|
|
|
cell type specific apoptotic process
|
GO:0097285 |
125 |
0.022
|
|
|
|
oogenesis
|
GO:0048477 |
2 |
0.022
|
|
|
|
cellular component assembly involved in morphogenesis
|
GO:0010927 |
73 |
0.022
|
|
|
|
regulation of growth
|
GO:0040008 |
165 |
0.022
|
|
|
|
positive regulation of cytoskeleton organization
|
GO:0051495 |
83 |
0.022
|
|
|
|
internal protein amino acid acetylation
|
GO:0006475 |
101 |
0.022
|
|
|
|
macromolecular complex disassembly
|
GO:0032984 |
60 |
0.022
|
|
|
|
glucosylceramide metabolic process
|
GO:0006678 |
3 |
0.022
|
|
|
|
nucleocytoplasmic transport
|
GO:0006913 |
176 |
0.022
|
|
|
|
response to insulin
|
GO:0032868 |
45 |
0.021
|
|
|
|
protein import
|
GO:0017038 |
130 |
0.021
|
|
|
|
regulation of membrane potential
|
GO:0042391 |
95 |
0.021
|
|
|
|
dephosphorylation
|
GO:0016311 |
209 |
0.021
|
|
|
|
regulation of heart rate
|
GO:0002027 |
38 |
0.021
|
|
|
|
regulation of glucose import
|
GO:0046324 |
21 |
0.021
|
|
|
|
positive regulation of secretion
|
GO:0051047 |
116 |
0.021
|
|
|
|
macromolecule glycosylation
|
GO:0043413 |
63 |
0.021
|
|
|
|
positive regulation of protein transport
|
GO:0051222 |
135 |
0.021
|
|
|
|
cell substrate adhesion
|
GO:0031589 |
132 |
0.021
|
|
|
|
anion transport
|
GO:0006820 |
161 |
0.021
|
|
|
|
enzyme linked receptor protein signaling pathway
|
GO:0007167 |
303 |
0.021
|
|
|
|
positive regulation of catabolic process
|
GO:0009896 |
310 |
0.021
|
|
|
|
hemopoiesis
|
GO:0030097 |
180 |
0.021
|
|
|
|
positive regulation of wnt signaling pathway
|
GO:0030177 |
54 |
0.020
|
|
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
267 |
0.020
|
|
|
|
regulation of protein stability
|
GO:0031647 |
87 |
0.020
|
|
|
|
cytokine production
|
GO:0001816 |
247 |
0.020
|
|
|
|
regulation of jnk cascade
|
GO:0046328 |
73 |
0.020
|
|
|
|
segmentation
|
GO:0035282 |
4 |
0.020
|
|
|
|
cardiac muscle contraction
|
GO:0060048 |
34 |
0.020
|
|
|
|
regulation of i kappab kinase nf kappab signaling
|
GO:0043122 |
162 |
0.020
|
|
|
|
hair cell differentiation
|
GO:0035315 |
2 |
0.020
|
|
|
|
response to metal ion
|
GO:0010038 |
84 |
0.020
|
|
|
|
positive regulation of neuron differentiation
|
GO:0045666 |
40 |
0.020
|
|
|
|
positive regulation of cell projection organization
|
GO:0031346 |
64 |
0.020
|
|
|
|
negative regulation of protein kinase activity
|
GO:0006469 |
98 |
0.020
|
|
|
|
sensory organ development
|
GO:0007423 |
52 |
0.020
|
|
|
|
negative regulation of cellular amino acid metabolic process
|
GO:0045763 |
2 |
0.020
|
|
|
|
regulation of protein localization to plasma membrane
|
GO:1903076 |
40 |
0.020
|
|
|
|
negative regulation of cell migration
|
GO:0030336 |
102 |
0.020
|
|
|
|
single fertilization
|
GO:0007338 |
11 |
0.020
|
Worm |
|
|
positive regulation of establishment of protein localization to plasma membrane
|
GO:0090004 |
18 |
0.020
|
|
|
|
epithelial cell differentiation
|
GO:0030855 |
141 |
0.020
|
|
|
|
negative regulation of phosphatase activity
|
GO:0010923 |
61 |
0.019
|
|
|
|
cellular response to oxygen levels
|
GO:0071453 |
55 |
0.019
|
|
|
|
negative regulation of voltage gated calcium channel activity
|
GO:1901386 |
4 |
0.019
|
Human |
|
|
mitotic cell cycle phase transition
|
GO:0044772 |
162 |
0.019
|
|
|
|
response to organonitrogen compound
|
GO:0010243 |
156 |
0.019
|
|
|
|
response to oxygen levels
|
GO:0070482 |
100 |
0.019
|
|
|
|
smoothened signaling pathway
|
GO:0007224 |
14 |
0.019
|
|
|
|
negative regulation of locomotion
|
GO:0040013 |
118 |
0.019
|
Worm |
|
|
cellular transition metal ion homeostasis
|
GO:0046916 |
21 |
0.019
|
|
|
|
adenylate cyclase activating g protein coupled receptor signaling pathway
|
GO:0007189 |
18 |
0.019
|
|
|
|
glycosylation
|
GO:0070085 |
71 |
0.019
|
|
|
|
angiogenesis
|
GO:0001525 |
147 |
0.019
|
|
|
|
system process
|
GO:0003008 |
349 |
0.019
|
|
|
|
cell morphogenesis
|
GO:0000902 |
296 |
0.019
|
|
|
|
glucose import
|
GO:0046323 |
24 |
0.019
|
|
|
|
organ morphogenesis
|
GO:0009887 |
147 |
0.019
|
Fly |
|
|
cell communication involved in cardiac conduction
|
GO:0086065 |
18 |
0.019
|
|
|
|
compound eye development
|
GO:0048749 |
1 |
0.019
|
|
|
|
positive regulation of protein serine threonine kinase activity
|
GO:0071902 |
119 |
0.019
|
|
|
|
embryo development ending in birth or egg hatching
|
GO:0009792 |
34 |
0.019
|
Worm |
|
|
asymmetric neuroblast division
|
GO:0055059 |
1 |
0.018
|
Fly |
|
|
protein ubiquitination
|
GO:0016567 |
314 |
0.018
|
|
|
|
regulation of transposition
|
GO:0010528 |
7 |
0.018
|
Yeast |
|
|
regulation of nucleocytoplasmic transport
|
GO:0046822 |
98 |
0.018
|
|
|
|
positive regulation of cell motility
|
GO:2000147 |
177 |
0.018
|
|
|
|
regulation of protein transport
|
GO:0051223 |
213 |
0.018
|
|
|
|
peptidyl serine autophosphorylation
|
GO:0036289 |
2 |
0.018
|
|
|
|
regulation of dephosphorylation
|
GO:0035303 |
96 |
0.018
|
|
|
|
lipid metabolic process
|
GO:0006629 |
381 |
0.018
|
|
|
|
cell junction organization
|
GO:0034330 |
79 |
0.018
|
|
|
|
cell matrix adhesion
|
GO:0007160 |
85 |
0.018
|
|
|
|
neuromuscular junction development
|
GO:0007528 |
3 |
0.018
|
|
|
|
regulation of neuron death
|
GO:1901214 |
56 |
0.018
|
|
|
|
actin filament based movement
|
GO:0030048 |
17 |
0.018
|
|
|
|
central nervous system development
|
GO:0007417 |
123 |
0.018
|
Human |
|
|
receptor mediated endocytosis
|
GO:0006898 |
84 |
0.018
|
|
|
|
activation induced cell death of t cells
|
GO:0006924 |
2 |
0.018
|
|
|
|
innate immune response
|
GO:0045087 |
178 |
0.017
|
|
|
|
establishment of organelle localization
|
GO:0051656 |
59 |
0.017
|
Worm |
|
|
motor neuron axon guidance
|
GO:0008045 |
2 |
0.017
|
|
|
|
regeneration
|
GO:0031099 |
4 |
0.017
|
|
|
|
negative regulation of programmed cell death
|
GO:0043069 |
321 |
0.017
|
|
|
|
regulation of purine nucleotide biosynthetic process
|
GO:1900371 |
50 |
0.017
|
|
|
|
nucleoside monophosphate metabolic process
|
GO:0009123 |
191 |
0.017
|
|
|
|
central nervous system projection neuron axonogenesis
|
GO:0021952 |
3 |
0.017
|
|
|
|
response to nutrient levels
|
GO:0031667 |
81 |
0.017
|
|
|
|
ectodermal placode development
|
GO:0071696 |
1 |
0.017
|
|
|
|
epithelial tube morphogenesis
|
GO:0060562 |
38 |
0.017
|
|
|
|
monosaccharide transport
|
GO:0015749 |
32 |
0.017
|
|
|
|
cellular response to nitrogen compound
|
GO:1901699 |
144 |
0.017
|
|
|
|
protein localization to nucleus
|
GO:0034504 |
136 |
0.017
|
|
|
|
multicellular organismal aging
|
GO:0010259 |
3 |
0.017
|
|
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
211 |
0.016
|
|
|
|
protein complex disassembly
|
GO:0043241 |
52 |
0.016
|
|
|
|
lipid biosynthetic process
|
GO:0008610 |
177 |
0.016
|
|
|
|
regulation of necrotic cell death
|
GO:0010939 |
9 |
0.016
|
|
|
|
negative regulation of mapk cascade
|
GO:0043409 |
56 |
0.016
|
|
|
|
response to peptide hormone
|
GO:0043434 |
61 |
0.016
|
|
|
|
regulation of cardiac muscle cell contraction
|
GO:0086004 |
23 |
0.016
|
|
|
|
hyperosmotic response
|
GO:0006972 |
4 |
0.016
|
|
|
|
hormone transport
|
GO:0009914 |
68 |
0.016
|
|
|
|
protein secretion
|
GO:0009306 |
98 |
0.016
|
|
|
|
chromatin modification
|
GO:0016568 |
298 |
0.016
|
|
|
|
striated muscle cell apoptotic process
|
GO:0010658 |
3 |
0.016
|
|
|
|
cell development
|
GO:0048468 |
328 |
0.015
|
|
|
|
regulation of cardiac muscle contraction
|
GO:0055117 |
33 |
0.015
|
|
|
|
negative regulation of cellular component movement
|
GO:0051271 |
106 |
0.015
|
|
|
|
growth hormone secretion
|
GO:0030252 |
4 |
0.015
|
|
|
|
chromatin organization
|
GO:0006325 |
351 |
0.015
|
|
|
|
vasculature development
|
GO:0001944 |
181 |
0.015
|
|
|
|
cell projection morphogenesis
|
GO:0048858 |
129 |
0.015
|
|
|
|
multi organism reproductive process
|
GO:0044703 |
54 |
0.015
|
Yeast Worm |
|
|
regulation of protein targeting
|
GO:1903533 |
91 |
0.015
|
|
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
244 |
0.015
|
|
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
175 |
0.015
|
|
|
|
response to parathyroid hormone
|
GO:0071107 |
3 |
0.015
|
|
|
|
cellular response to hypoxia
|
GO:0071456 |
51 |
0.015
|
|
|
|
negative regulation of transcription from rna polymerase ii promoter
|
GO:0000122 |
281 |
0.015
|
|
|
|
peptide hormone secretion
|
GO:0030072 |
50 |
0.015
|
|
|
|
response to fungus
|
GO:0009620 |
4 |
0.015
|
|
|
|
regulation of glucose transport
|
GO:0010827 |
23 |
0.015
|
|
|
|
positive regulation of nucleoside metabolic process
|
GO:0045979 |
186 |
0.015
|
|
|
|
epithelium migration
|
GO:0090132 |
119 |
0.015
|
|
|
|
nucleotide biosynthetic process
|
GO:0009165 |
109 |
0.015
|
|
|
|
positive regulation of erk1 and erk2 cascade
|
GO:0070374 |
75 |
0.015
|
|
|
|
regulation of nucleotide metabolic process
|
GO:0006140 |
269 |
0.015
|
Yeast |
|
|
heart process
|
GO:0003015 |
62 |
0.015
|
|
|
|
oocyte differentiation
|
GO:0009994 |
2 |
0.015
|
|
|
|
positive regulation of intracellular transport
|
GO:0032388 |
104 |
0.015
|
|
