Homo sapiens

60 known processes

GOT1

glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)

(Aliases: GIG18)

GOT1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
post embryonic development GO:0009791 2 0.527
cellular amino acid metabolic process GO:0006520 116 0.471
dicarboxylic acid biosynthetic process GO:0043650 4 0.321
Yeast Mouse
dicarboxylic acid metabolic process GO:0043648 29 0.282
glutamate metabolic process GO:0006536 10 0.280
Mouse
tricarboxylic acid cycle GO:0006099 4 0.245
tricarboxylic acid metabolic process GO:0072350 4 0.224
citrate metabolic process GO:0006101 2 0.210
cellular amino acid biosynthetic process GO:0008652 30 0.203
Yeast Mouse
female gamete generation GO:0007292 2 0.192
oxidation reduction process GO:0055114 396 0.181
dicarboxylic acid catabolic process GO:0043649 9 0.176
cellular amino acid catabolic process GO:0009063 31 0.153
oogenesis GO:0048477 2 0.123
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 49 0.107
positive regulation of hydrolase activity GO:0051345 331 0.104
nervous system development GO:0007399 293 0.104
multicellular organismal aging GO:0010259 3 0.100
positive regulation of proteolysis GO:0045862 142 0.094
alpha amino acid metabolic process GO:1901605 72 0.093
regulation of peptidase activity GO:0052547 180 0.091
small molecule biosynthetic process GO:0044283 157 0.087
Yeast Mouse
positive regulation of peptidase activity GO:0010952 88 0.085
zymogen activation GO:0031638 70 0.081
sulfur compound metabolic process GO:0006790 101 0.080
vesicle mediated transport GO:0016192 371 0.079
trna aminoacylation GO:0043039 12 0.078
determination of adult lifespan GO:0008340 2 0.078
alpha amino acid catabolic process GO:1901606 26 0.076
protein processing GO:0016485 226 0.075
embryo development GO:0009790 123 0.073
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.072
regulation of cysteine type endopeptidase activity GO:2000116 127 0.069
sulfur compound biosynthetic process GO:0044272 38 0.068
regulation of endopeptidase activity GO:0052548 170 0.067
organonitrogen compound biosynthetic process GO:1901566 200 0.067
Yeast Mouse
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.064
aerobic respiration GO:0009060 7 0.059
cation transmembrane transport GO:0098655 238 0.055
chemical homeostasis GO:0048878 306 0.055
Mouse
nadh dehydrogenase complex assembly GO:0010257 16 0.054
carboxylic acid catabolic process GO:0046395 71 0.053
protein maturation GO:0051604 233 0.052
negative regulation of apoptotic process GO:0043066 316 0.051
mitochondrial respiratory chain complex i biogenesis GO:0097031 16 0.050
regulation of proteolysis GO:0030162 293 0.048
carbohydrate metabolic process GO:0005975 207 0.047
Mouse
cofactor biosynthetic process GO:0051188 31 0.047
amine metabolic process GO:0009308 44 0.047
purine nucleoside triphosphate metabolic process GO:0009144 412 0.046
positive regulation of cell death GO:0010942 263 0.045
coenzyme metabolic process GO:0006732 65 0.044
positive regulation of programmed cell death GO:0043068 249 0.043
neuromuscular junction development GO:0007528 3 0.043
thioester biosynthetic process GO:0035384 6 0.042
carboxylic acid biosynthetic process GO:0046394 97 0.041
Yeast Mouse
positive regulation of cellular component organization GO:0051130 376 0.041
cation transport GO:0006812 331 0.041
activation of cysteine type endopeptidase activity GO:0097202 57 0.041
regulation of cellular amine metabolic process GO:0033238 11 0.040
generation of precursor metabolites and energy GO:0006091 68 0.040
cellular protein complex assembly GO:0043623 188 0.040
system process GO:0003008 349 0.039
purine ribonucleoside metabolic process GO:0046128 437 0.039
acyl coa biosynthetic process GO:0071616 6 0.039
single organism carbohydrate metabolic process GO:0044723 193 0.038
Mouse
positive regulation of catabolic process GO:0009896 310 0.038
protein oligomerization GO:0051259 173 0.036
cellular macromolecule catabolic process GO:0044265 380 0.036
cellular ion homeostasis GO:0006873 168 0.035
posttranscriptional regulation of gene expression GO:0010608 213 0.035
nucleoside triphosphate metabolic process GO:0009141 422 0.034
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.033
pyridine nucleotide metabolic process GO:0019362 14 0.033
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.032
spermatid differentiation GO:0048515 4 0.032
organic acid biosynthetic process GO:0016053 97 0.031
Yeast Mouse
cellular response to cytokine stimulus GO:0071345 181 0.031
isocitrate metabolic process GO:0006102 1 0.030
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.030
glutamate biosynthetic process GO:0006537 3 0.030
maintenance of location GO:0051235 112 0.030
positive regulation of endopeptidase activity GO:0010950 84 0.030
ion transmembrane transport GO:0034220 338 0.030
regulation of membrane potential GO:0042391 95 0.029
energy derivation by oxidation of organic compounds GO:0015980 43 0.029
ribonucleoside triphosphate metabolic process GO:0009199 412 0.029
cellular amine metabolic process GO:0044106 41 0.029
glutamine family amino acid metabolic process GO:0009064 17 0.028
Mouse
regulation of cellular amino acid metabolic process GO:0006521 6 0.028
cellular component disassembly GO:0022411 92 0.027
cellular cation homeostasis GO:0030003 163 0.027
anatomical structure formation involved in morphogenesis GO:0048646 284 0.027
response to abiotic stimulus GO:0009628 336 0.027
carbohydrate derivative biosynthetic process GO:1901137 207 0.027
blood vessel morphogenesis GO:0048514 162 0.027
negative regulation of cell death GO:0060548 345 0.027
glutamine family amino acid biosynthetic process GO:0009084 5 0.027
cellular macromolecular complex assembly GO:0034622 324 0.027
metal ion transport GO:0030001 272 0.026
negative regulation of programmed cell death GO:0043069 321 0.026
pyruvate metabolic process GO:0006090 26 0.026
actin filament based process GO:0030029 224 0.026
positive regulation of organelle organization GO:0010638 195 0.026
calcium ion transport GO:0006816 147 0.026
protein acylation GO:0043543 138 0.025
cofactor metabolic process GO:0051186 87 0.025
cellular respiration GO:0045333 21 0.025
atp metabolic process GO:0046034 176 0.025
negative regulation of intracellular signal transduction GO:1902532 183 0.025
regulation of cellular component biogenesis GO:0044087 281 0.024
hindbrain development GO:0030902 3 0.024
anion transport GO:0006820 161 0.024
cellular ketone metabolic process GO:0042180 80 0.023
positive regulation of immune system process GO:0002684 283 0.023
immune response GO:0006955 307 0.023
positive regulation of apoptotic process GO:0043065 246 0.023
purine ribonucleoside catabolic process GO:0046130 398 0.023
ribonucleotide catabolic process GO:0009261 405 0.022
cellular chemical homeostasis GO:0055082 180 0.022
mitochondrial respiratory chain complex assembly GO:0033108 23 0.022
response to oxygen containing compound GO:1901700 369 0.022
oxidoreduction coenzyme metabolic process GO:0006733 19 0.022
inorganic cation transmembrane transport GO:0098662 194 0.022
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.022
regeneration GO:0031099 4 0.022
segmentation GO:0035282 4 0.021
purine ribonucleotide catabolic process GO:0009154 404 0.021
rna interference GO:0016246 4 0.021
translation GO:0006412 132 0.021
regulation of immune response GO:0050776 201 0.021
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.021
organic acid transport GO:0015849 65 0.021
regulation of protein complex assembly GO:0043254 147 0.021
regulation of protein maturation GO:1903317 150 0.021
monocarboxylic acid metabolic process GO:0032787 185 0.021
aspartate family amino acid catabolic process GO:0009068 5 0.021
carboxylic acid transport GO:0046942 63 0.021
regulation of ion transport GO:0043269 189 0.021
inorganic ion transmembrane transport GO:0098660 231 0.020
secretion GO:0046903 254 0.020
response to cytokine GO:0034097 232 0.020
cardiovascular system development GO:0072358 262 0.020
positive regulation of cellular catabolic process GO:0031331 284 0.020
spinal cord development GO:0021510 4 0.020
defense response GO:0006952 315 0.020
anterior posterior axis specification GO:0009948 2 0.020
cell cell signaling GO:0007267 155 0.019
negative regulation of phosphorus metabolic process GO:0010563 267 0.019
biological adhesion GO:0022610 331 0.019
negative regulation of hydrolase activity GO:0051346 182 0.019
receptor metabolic process GO:0043112 81 0.019
organophosphate biosynthetic process GO:0090407 163 0.019
secretion by cell GO:0032940 226 0.019
negative regulation of phosphate metabolic process GO:0045936 267 0.019
endocytosis GO:0006897 159 0.019
cellular homeostasis GO:0019725 196 0.019
immune system development GO:0002520 195 0.019
organelle assembly GO:0070925 176 0.018
innate immune response GO:0045087 178 0.018
organophosphate catabolic process GO:0046434 430 0.018
regulation of cellular ketone metabolic process GO:0010565 50 0.018
apoptotic mitochondrial changes GO:0008637 57 0.018
tissue regeneration GO:0042246 3 0.018
myosin filament assembly GO:0031034 2 0.018
fatty acid transport GO:0015908 25 0.018
neurological system process GO:0050877 163 0.018
transmembrane transport GO:0055085 399 0.018
nucleotide catabolic process GO:0009166 408 0.018
dna catabolic process GO:0006308 49 0.018
metencephalon development GO:0022037 2 0.018
phototransduction GO:0007602 3 0.017
protein tetramerization GO:0051262 47 0.017
regulation of nucleotide catabolic process GO:0030811 205 0.017
regulation of purine nucleotide catabolic process GO:0033121 205 0.017
angiogenesis GO:0001525 147 0.017
divalent inorganic cation homeostasis GO:0072507 136 0.017
nadh metabolic process GO:0006734 1 0.017
negative regulation of cellular protein metabolic process GO:0032269 353 0.017
positive regulation of cellular amine metabolic process GO:0033240 7 0.017
regulation of nucleoside metabolic process GO:0009118 209 0.017
cell morphogenesis GO:0000902 296 0.017
nerve development GO:0021675 4 0.017
lipid transport GO:0006869 90 0.017
membrane organization GO:0061024 292 0.016
negative regulation of phosphorylation GO:0042326 174 0.016
coenzyme biosynthetic process GO:0009108 24 0.016
nucleoside catabolic process GO:0009164 408 0.016
blastoderm segmentation GO:0007350 2 0.016
aspartate metabolic process GO:0006531 4 0.016
amino acid activation GO:0043038 12 0.016
cytokine production GO:0001816 247 0.016
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.016
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.016
single organism membrane organization GO:0044802 268 0.016
spermatid development GO:0007286 4 0.016
purine containing compound catabolic process GO:0072523 411 0.016
microtubule based process GO:0007017 210 0.015
protein refolding GO:0042026 14 0.015
cellular metal ion homeostasis GO:0006875 146 0.015
reproductive process GO:0022414 106 0.015
divalent inorganic cation transport GO:0072511 158 0.015
hemopoiesis GO:0030097 180 0.015
memory GO:0007613 3 0.015
microtubule cytoskeleton organization GO:0000226 176 0.015
regulation of hormone levels GO:0010817 125 0.015
growth GO:0040007 202 0.015
reproduction GO:0000003 63 0.015
negative regulation of catalytic activity GO:0043086 335 0.015
hematopoietic or lymphoid organ development GO:0048534 186 0.015
patterning of blood vessels GO:0001569 2 0.015
organic anion transport GO:0015711 103 0.015
regulation of protein processing GO:0070613 150 0.015
ion homeostasis GO:0050801 230 0.015
Mouse
negative regulation of protein modification process GO:0031400 200 0.014
cytokine mediated signaling pathway GO:0019221 109 0.014
cell development GO:0048468 328 0.014
sleep GO:0030431 2 0.014
regulation of purine nucleotide metabolic process GO:1900542 264 0.014
positive regulation of developmental process GO:0051094 314 0.014
cellular component morphogenesis GO:0032989 314 0.014
organic hydroxy compound metabolic process GO:1901615 147 0.014
Mouse
receptor mediated endocytosis GO:0006898 84 0.014
cellular protein catabolic process GO:0044257 261 0.014
small molecule catabolic process GO:0044282 92 0.014
ribonucleoside monophosphate metabolic process GO:0009161 187 0.014
purine nucleoside catabolic process GO:0006152 398 0.014
vasculature development GO:0001944 181 0.014
synaptic transmission GO:0007268 61 0.014
trna aminoacylation for protein translation GO:0006418 8 0.014
2 oxoglutarate metabolic process GO:0006103 4 0.014
Mouse
nucleoside triphosphate catabolic process GO:0009143 394 0.014
cellular amide metabolic process GO:0043603 69 0.014
monovalent inorganic cation transport GO:0015672 128 0.014
circulatory system development GO:0072359 262 0.014
blood vessel development GO:0001568 172 0.014
nucleotide biosynthetic process GO:0009165 109 0.014
apoptotic signaling pathway GO:0097190 268 0.014
negative regulation of proteolysis GO:0045861 132 0.014
locomotory behavior GO:0007626 1 0.014
nicotinamide nucleotide metabolic process GO:0046496 14 0.014
monocarboxylic acid transport GO:0015718 32 0.013
regulation of cell adhesion GO:0030155 166 0.013
regulation of nucleotide metabolic process GO:0006140 269 0.013
purine nucleotide catabolic process GO:0006195 405 0.013
neuron differentiation GO:0030182 138 0.013
dephosphorylation GO:0016311 209 0.013
response to hormone GO:0009725 175 0.013
purine nucleoside triphosphate catabolic process GO:0009146 392 0.013
ribose phosphate biosynthetic process GO:0046390 82 0.013
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.013
one carbon metabolic process GO:0006730 1 0.013
generation of neurons GO:0048699 152 0.013
epithelium development GO:0060429 227 0.013
negative regulation of protein metabolic process GO:0051248 391 0.013
regulation of atpase activity GO:0043462 25 0.013
regulation of neural precursor cell proliferation GO:2000177 4 0.013
reactive oxygen species metabolic process GO:0072593 75 0.013
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.013
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.013
syncytium formation by plasma membrane fusion GO:0000768 2 0.013
cell differentiation in spinal cord GO:0021515 1 0.013
regulation of defense response GO:0031347 154 0.013
response to lipid GO:0033993 206 0.013
divalent metal ion transport GO:0070838 152 0.013
purine nucleoside monophosphate metabolic process GO:0009126 186 0.013
cellular calcium ion homeostasis GO:0006874 117 0.013
ribonucleoside catabolic process GO:0042454 406 0.012
neuroblast proliferation GO:0007405 4 0.012
negative regulation of protein maturation GO:1903318 142 0.012
regulation of kinase activity GO:0043549 314 0.012
central nervous system development GO:0007417 123 0.012
nucleoside monophosphate metabolic process GO:0009123 191 0.012
regulation of cell development GO:0060284 161 0.012
guanosine containing compound catabolic process GO:1901069 239 0.012
tripartite regional subdivision GO:0007351 2 0.012
apoptotic nuclear changes GO:0030262 13 0.012
cell adhesion GO:0007155 325 0.012
tissue homeostasis GO:0001894 63 0.012
protein homooligomerization GO:0051260 100 0.012
negative regulation of multicellular organismal process GO:0051241 317 0.012
protein stabilization GO:0050821 64 0.012
lipid metabolic process GO:0006629 381 0.012
positive regulation of dna metabolic process GO:0051054 73 0.012
negative regulation of cellular amine metabolic process GO:0033239 3 0.012
reactive oxygen species biosynthetic process GO:1903409 4 0.012
cell activation GO:0001775 213 0.012
nucleoside phosphate catabolic process GO:1901292 412 0.012
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.012
multicellular organismal reproductive process GO:0048609 40 0.011
wound healing GO:0042060 115 0.011
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.011
metal ion homeostasis GO:0055065 169 0.011
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.011
cellular response to oxygen containing compound GO:1901701 276 0.011
negative regulation of cellular component organization GO:0051129 235 0.011
internal protein amino acid acetylation GO:0006475 101 0.011
cell projection organization GO:0030030 252 0.011
homeostasis of number of cells GO:0048872 40 0.011
ribonucleoside triphosphate catabolic process GO:0009203 391 0.011
negative regulation of protein processing GO:0010955 142 0.011
regulation of cytokine production GO:0001817 232 0.011
cell growth GO:0016049 160 0.011
glucose metabolic process GO:0006006 45 0.011
positive regulation of mitochondrion organization GO:0010822 30 0.011
embryo development ending in birth or egg hatching GO:0009792 34 0.011
purine containing compound biosynthetic process GO:0072522 88 0.011
regulation of cytoskeleton organization GO:0051493 177 0.011
anatomical structure homeostasis GO:0060249 100 0.011
cellular component disassembly involved in execution phase of apoptosis GO:0006921 13 0.011
reproductive structure development GO:0048608 55 0.011
protein catabolic process GO:0030163 325 0.011
head development GO:0060322 108 0.011
acetyl coa biosynthetic process from pyruvate GO:0006086 4 0.011
myeloid cell differentiation GO:0030099 117 0.011
cation homeostasis GO:0055080 189 0.011
regulation of innate immune response GO:0045088 97 0.011
ventral spinal cord development GO:0021517 1 0.011
regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902108 18 0.011
cerebellum development GO:0021549 2 0.010
response to interferon gamma GO:0034341 39 0.010
positive regulation of phosphorylation GO:0042327 394 0.010
negative regulation of transferase activity GO:0051348 124 0.010
positive regulation of cell differentiation GO:0045597 211 0.010
rho protein signal transduction GO:0007266 26 0.010
single organism cellular localization GO:1902580 332 0.010
response to wounding GO:0009611 168 0.010
positive regulation of immune response GO:0050778 159 0.010
protein acetylation GO:0006473 116 0.010
oocyte development GO:0048599 1 0.010
reactive nitrogen species metabolic process GO:2001057 3 0.010
striated muscle myosin thick filament assembly GO:0071688 2 0.010

GOT1 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.191
inherited metabolic disorder DOID:655 242 0.191
nervous system disease DOID:863 431 0.158
neuropathy DOID:870 52 0.158
immune system disease DOID:2914 155 0.119
neuromuscular disease DOID:440 38 0.106
amino acid metabolic disorder DOID:9252 50 0.074
hematopoietic system disease DOID:74 100 0.071
central nervous system disease DOID:331 186 0.050
sensory system disease DOID:0050155 203 0.046
leigh disease DOID:3652 16 0.045
mitochondrial metabolism disease DOID:700 29 0.045
coenzyme q10 deficiency disease DOID:0050730 6 0.040
eye and adnexa disease DOID:1492 150 0.029
eye disease DOID:5614 149 0.029
neurodegenerative disease DOID:1289 102 0.018
cancer DOID:162 167 0.017
disease of cellular proliferation DOID:14566 174 0.017
organ system cancer DOID:0050686 164 0.017
retinal disease DOID:5679 118 0.015
carbohydrate metabolic disorder DOID:2978 55 0.014