Homo sapiens

0 known processes

GPX4

glutathione peroxidase 4 (phospholipid hydroperoxidase)

(Aliases: MCSP,PHGPx,snPHGPx,snGPx)

GPX4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
glutathione metabolic process GO:0006749 20 0.460
oxidation reduction process GO:0055114 396 0.440
reactive oxygen species metabolic process GO:0072593 75 0.434
negative regulation of cell death GO:0060548 345 0.356
response to oxygen containing compound GO:1901700 369 0.220
regulation of endopeptidase activity GO:0052548 170 0.219
post embryonic development GO:0009791 2 0.206
negative regulation of catalytic activity GO:0043086 335 0.195
determination of adult lifespan GO:0008340 2 0.173
mitochondrion organization GO:0007005 156 0.159
cellular response to reactive oxygen species GO:0034614 50 0.158
negative regulation of apoptotic process GO:0043066 316 0.154
regulation of protein catabolic process GO:0042176 155 0.139
cellular response to hydrogen peroxide GO:0070301 37 0.139
hydrogen peroxide metabolic process GO:0042743 20 0.132
cellular response to oxygen containing compound GO:1901701 276 0.128
negative regulation of protein metabolic process GO:0051248 391 0.119
regulation of peptidase activity GO:0052547 180 0.110
response to oxidative stress GO:0006979 121 0.110
response to inorganic substance GO:0010035 127 0.108
hydrogen peroxide catabolic process GO:0042744 13 0.103
cellular lipid metabolic process GO:0044255 303 0.102
negative regulation of cellular protein metabolic process GO:0032269 353 0.095
cellular response to oxidative stress GO:0034599 85 0.094
protein processing GO:0016485 226 0.094
response to reactive oxygen species GO:0000302 61 0.092
protein maturation GO:0051604 233 0.090
negative regulation of programmed cell death GO:0043069 321 0.089
detection of muramyl dipeptide GO:0032498 1 0.087
response to hydrogen peroxide GO:0042542 40 0.085
regulation of cysteine type endopeptidase activity GO:2000116 127 0.083
lipid metabolic process GO:0006629 381 0.082
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.079
cellular amino acid metabolic process GO:0006520 116 0.078
regulation of protein maturation GO:1903317 150 0.077
bleb assembly GO:0032060 6 0.074
negative regulation of cysteine type endopeptidase activity GO:2000117 48 0.074
transmembrane transport GO:0055085 399 0.072
response to abiotic stimulus GO:0009628 336 0.068
negative regulation of apoptotic signaling pathway GO:2001234 97 0.066
membrane organization GO:0061024 292 0.066
release of cytochrome c from mitochondria GO:0001836 35 0.065
phospholipid metabolic process GO:0006644 99 0.064
mitotic cell cycle GO:0000278 326 0.063
multicellular organismal aging GO:0010259 3 0.060
regulation of protein processing GO:0070613 150 0.060
cellular protein catabolic process GO:0044257 261 0.058
lipid catabolic process GO:0016042 84 0.057
negative regulation of protein maturation GO:1903318 142 0.055
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.055
inorganic cation transmembrane transport GO:0098662 194 0.053
cation transport GO:0006812 331 0.053
negative regulation of peptidase activity GO:0010466 91 0.051
protein catabolic process GO:0030163 325 0.051
regulation of cellular component biogenesis GO:0044087 281 0.050
system process GO:0003008 349 0.049
cellular homeostasis GO:0019725 196 0.049
negative regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043154 46 0.048
positive regulation of cell death GO:0010942 263 0.047
cellular lipid catabolic process GO:0044242 65 0.047
positive regulation of phosphorylation GO:0042327 394 0.046
cellular ketone metabolic process GO:0042180 80 0.046
mapk cascade GO:0000165 288 0.045
positive regulation of kinase activity GO:0033674 204 0.045
vesicle mediated transport GO:0016192 371 0.045
cellular amide metabolic process GO:0043603 69 0.045
positive regulation of cellular amine metabolic process GO:0033240 7 0.044
cellular modified amino acid metabolic process GO:0006575 64 0.043
regulation of mitochondrion organization GO:0010821 54 0.043
signal transduction by phosphorylation GO:0023014 297 0.043
negative regulation of proteolysis GO:0045861 132 0.042
regulation of cellular protein catabolic process GO:1903362 96 0.042
phospholipid catabolic process GO:0009395 12 0.042
regulation of mapk cascade GO:0043408 262 0.041
negative regulation of hydrolase activity GO:0051346 182 0.039
inorganic ion transmembrane transport GO:0098660 231 0.038
regulation of body fluid levels GO:0050878 99 0.038
organonitrogen compound biosynthetic process GO:1901566 200 0.037
protein localization to organelle GO:0033365 280 0.036
positive regulation of transport GO:0051050 336 0.035
wnt signaling pathway GO:0016055 156 0.035
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.035
mitochondrial transport GO:0006839 60 0.034
response to lipid GO:0033993 206 0.034
carbohydrate derivative biosynthetic process GO:1901137 207 0.034
extrinsic apoptotic signaling pathway GO:0097191 119 0.034
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.033
regulation of cell cycle GO:0051726 393 0.033
negative regulation of endopeptidase activity GO:0010951 84 0.033
blood coagulation GO:0007596 76 0.033
regulation of proteolysis GO:0030162 293 0.033
cellular macromolecular complex assembly GO:0034622 324 0.033
regulation of transferase activity GO:0051338 355 0.032
positive regulation of mapk cascade GO:0043410 190 0.032
regulation of proteasomal protein catabolic process GO:0061136 87 0.032
intracellular protein transport GO:0006886 270 0.032
regulation of reactive oxygen species metabolic process GO:2000377 41 0.032
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.031
negative regulation of phosphorus metabolic process GO:0010563 267 0.031
apoptotic signaling pathway GO:0097190 268 0.031
small molecule biosynthetic process GO:0044283 157 0.030
peptide metabolic process GO:0006518 51 0.030
positive regulation of cell proliferation GO:0008284 301 0.029
carbohydrate metabolic process GO:0005975 207 0.029
negative regulation of protein processing GO:0010955 142 0.029
single organism cellular localization GO:1902580 332 0.029
proteasomal protein catabolic process GO:0010498 176 0.029
epithelial cell proliferation GO:0050673 128 0.029
regulation of cell motility GO:2000145 299 0.029
regulation of apoptotic signaling pathway GO:2001233 175 0.028
regulation of cell differentiation GO:0045595 393 0.028
cytoplasmic transport GO:0016482 379 0.027
positive regulation of cellular component biogenesis GO:0044089 158 0.027
ion transmembrane transport GO:0034220 338 0.027
regulation of canonical wnt signaling pathway GO:0060828 88 0.027
positive regulation of developmental process GO:0051094 314 0.027
negative regulation of multicellular organismal process GO:0051241 317 0.026
regulation of wnt signaling pathway GO:0030111 123 0.026
positive regulation of catabolic process GO:0009896 310 0.026
regulation of kinase activity GO:0043549 314 0.026
hemostasis GO:0007599 76 0.026
canonical wnt signaling pathway GO:0060070 116 0.025
regulation of cellular amine metabolic process GO:0033238 11 0.025
response to bacterium GO:0009617 144 0.025
response to wounding GO:0009611 168 0.025
regulation of mitotic cell cycle GO:0007346 189 0.025
positive regulation of protein phosphorylation GO:0001934 313 0.025
negative regulation of cellular component organization GO:0051129 235 0.024
heart contraction GO:0060047 62 0.024
coenzyme metabolic process GO:0006732 65 0.024
immune response GO:0006955 307 0.024
positive regulation of protein kinase activity GO:0045860 190 0.023
positive regulation of programmed cell death GO:0043068 249 0.023
modification dependent macromolecule catabolic process GO:0043632 212 0.023
single organism membrane organization GO:0044802 268 0.023
microtubule cytoskeleton organization GO:0000226 176 0.023
mitotic cell cycle process GO:1903047 286 0.023
regulation of anatomical structure morphogenesis GO:0022603 286 0.023
positive regulation of hydrolase activity GO:0051345 331 0.023
heart process GO:0003015 62 0.023
ras protein signal transduction GO:0007265 73 0.022
positive regulation of transferase activity GO:0051347 227 0.022
enzyme linked receptor protein signaling pathway GO:0007167 303 0.022
regulation of protein kinase activity GO:0045859 289 0.022
protein targeting GO:0006605 187 0.022
epithelium development GO:0060429 227 0.022
response to hormone GO:0009725 175 0.021
single organism carbohydrate metabolic process GO:0044723 193 0.021
regulation of purine nucleotide metabolic process GO:1900542 264 0.021
neuroblast proliferation GO:0007405 4 0.021
regeneration GO:0031099 4 0.021
response to cytokine GO:0034097 232 0.021
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.021
female gamete generation GO:0007292 2 0.021
response to biotic stimulus GO:0009607 276 0.021
thymus development GO:0048538 3 0.021
positive regulation of cellular component organization GO:0051130 376 0.021
cell activation GO:0001775 213 0.021
regulation of immune response GO:0050776 201 0.020
cell projection assembly GO:0030031 126 0.020
negative regulation of organelle organization GO:0010639 126 0.020
defense response GO:0006952 315 0.020
organophosphate catabolic process GO:0046434 430 0.020
wound healing GO:0042060 115 0.020
organophosphate biosynthetic process GO:0090407 163 0.020
cellular macromolecule catabolic process GO:0044265 380 0.020
protein ubiquitination GO:0016567 314 0.020
negative regulation of phosphate metabolic process GO:0045936 267 0.020
regulation of epithelial cell proliferation GO:0050678 113 0.020
coagulation GO:0050817 78 0.020
mitochondrial membrane organization GO:0007006 40 0.019
negative regulation of protein modification process GO:0031400 200 0.019
oxidoreduction coenzyme metabolic process GO:0006733 19 0.019
regulation of map kinase activity GO:0043405 108 0.019
cation transmembrane transport GO:0098655 238 0.019
secretion by cell GO:0032940 226 0.019
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.019
regulation of glomerulus development GO:0090192 3 0.019
response to light stimulus GO:0009416 87 0.018
regulation of cellular amino acid metabolic process GO:0006521 6 0.018
positive regulation of cellular component movement GO:0051272 181 0.018
regulation of protein localization GO:0032880 296 0.018
endomembrane system organization GO:0010256 196 0.018
regulation of protein serine threonine kinase activity GO:0071900 179 0.018
cellular response to lipid GO:0071396 127 0.018
erk1 and erk2 cascade GO:0070371 104 0.018
positive regulation of immune system process GO:0002684 283 0.018
cellular protein complex assembly GO:0043623 188 0.018
cellular cation homeostasis GO:0030003 163 0.018
positive regulation of locomotion GO:0040017 186 0.017
secretion GO:0046903 254 0.017
divalent inorganic cation transport GO:0072511 158 0.017
protein deubiquitination GO:0016579 79 0.017
response to oxygen levels GO:0070482 100 0.017
positive regulation of protein catabolic process GO:0045732 75 0.017
activation of protein kinase activity GO:0032147 90 0.017
response to hypoxia GO:0001666 96 0.017
segmentation GO:0035282 4 0.017
regulation of cell cycle process GO:0010564 266 0.017
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.017
reactive nitrogen species metabolic process GO:2001057 3 0.017
organic acid biosynthetic process GO:0016053 97 0.016
regulation of secretion GO:0051046 194 0.016
regulation of erk1 and erk2 cascade GO:0070372 99 0.016
response to mercury ion GO:0046689 4 0.016
response to molecule of bacterial origin GO:0002237 82 0.016
calcium ion transport GO:0006816 147 0.016
cell adhesion GO:0007155 325 0.016
regulation of response to wounding GO:1903034 101 0.016
cardiac muscle cell contraction GO:0086003 4 0.016
single organism cell adhesion GO:0098602 179 0.016
regulation of locomotion GO:0040012 329 0.016
apoptotic mitochondrial changes GO:0008637 57 0.016
regulation of cellular component movement GO:0051270 334 0.016
cellular chemical homeostasis GO:0055082 180 0.016
tissue homeostasis GO:0001894 63 0.016
modification dependent protein catabolic process GO:0019941 209 0.016
cofactor metabolic process GO:0051186 87 0.015
purine ribonucleoside metabolic process GO:0046128 437 0.015
embryo development GO:0009790 123 0.015
ribonucleoside triphosphate metabolic process GO:0009199 412 0.015
endocytosis GO:0006897 159 0.015
cellular response to cytokine stimulus GO:0071345 181 0.015
regulation of cellular ketone metabolic process GO:0010565 50 0.015
microtubule based process GO:0007017 210 0.015
regulation of ion transmembrane transport GO:0034765 132 0.015
cell growth GO:0016049 160 0.015
regulation of cell activation GO:0050865 125 0.014
cellular response to endogenous stimulus GO:0071495 336 0.014
maintenance of location in cell GO:0051651 62 0.014
negative regulation of intracellular signal transduction GO:1902532 183 0.014
peptidyl serine modification GO:0018209 106 0.014
pyridine nucleotide metabolic process GO:0019362 14 0.014
regulation of ras protein signal transduction GO:0046578 155 0.014
adult locomotory behavior GO:0008344 1 0.014
establishment of protein localization to organelle GO:0072594 172 0.014
cell projection organization GO:0030030 252 0.014
peptidyl tyrosine modification GO:0018212 170 0.014
negative regulation of transferase activity GO:0051348 124 0.014
small molecule catabolic process GO:0044282 92 0.014
metencephalon development GO:0022037 2 0.014
central nervous system development GO:0007417 123 0.014
anatomical structure homeostasis GO:0060249 100 0.014
response to other organism GO:0051707 261 0.014
positive regulation of secretion by cell GO:1903532 108 0.014
maintenance of location GO:0051235 112 0.013
posttranscriptional regulation of gene expression GO:0010608 213 0.013
multicellular organismal homeostasis GO:0048871 67 0.013
regulation of neural precursor cell proliferation GO:2000177 4 0.013
amine metabolic process GO:0009308 44 0.013
circulatory system process GO:0003013 113 0.013
cellular response to nitrogen compound GO:1901699 144 0.013
peptidyl serine phosphorylation GO:0018105 101 0.013
establishment of protein localization to membrane GO:0090150 121 0.013
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 42 0.013
positive regulation of proteolysis GO:0045862 142 0.013
regulation of protein transport GO:0051223 213 0.013
protein localization to membrane GO:0072657 160 0.013
response to decreased oxygen levels GO:0036293 96 0.013
regulation of growth GO:0040008 165 0.013
negative regulation of cell proliferation GO:0008285 228 0.013
nucleotide biosynthetic process GO:0009165 109 0.013
hematopoietic or lymphoid organ development GO:0048534 186 0.013
purine nucleotide catabolic process GO:0006195 405 0.013
protein homooligomerization GO:0051260 100 0.013
mitochondrial respiratory chain complex assembly GO:0033108 23 0.013
divalent metal ion transport GO:0070838 152 0.013
positive regulation of necrotic cell death GO:0010940 4 0.012
biological adhesion GO:0022610 331 0.012
energy derivation by oxidation of organic compounds GO:0015980 43 0.012
rna interference GO:0016246 4 0.012
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.012
epithelial cell migration GO:0010631 119 0.012
hexose metabolic process GO:0019318 55 0.012
nadph oxidation GO:0070995 3 0.012
innate immune response GO:0045087 178 0.012
positive regulation of cell differentiation GO:0045597 211 0.012
metal ion transport GO:0030001 272 0.012
response to drug GO:0042493 81 0.012
response to metal ion GO:0010038 84 0.012
negative regulation of cell cycle GO:0045786 193 0.012
positive regulation of organelle organization GO:0010638 195 0.012
regulation of gene expression epigenetic GO:0040029 73 0.012
epithelial cell differentiation GO:0030855 141 0.012
regulation of cellular response to stress GO:0080135 244 0.012
acetylcholine transport GO:0015870 1 0.012
fibroblast proliferation GO:0048144 33 0.012
cell substrate adhesion GO:0031589 132 0.012
negative regulation of wnt signaling pathway GO:0030178 69 0.012
sequestering of metal ion GO:0051238 24 0.011
negative regulation of growth GO:0045926 97 0.011
regulation of mhc class i biosynthetic process GO:0045343 4 0.011
immune effector process GO:0002252 159 0.011
autophagy GO:0006914 88 0.011
protein oligomerization GO:0051259 173 0.011
regulation of multi organism process GO:0043900 157 0.011
tissue regeneration GO:0042246 3 0.011
purine containing compound biosynthetic process GO:0072522 88 0.011
regulation of wound healing GO:0061041 56 0.011
response to axon injury GO:0048678 1 0.011
response to external biotic stimulus GO:0043207 261 0.011
purine containing compound catabolic process GO:0072523 411 0.011
dephosphorylation GO:0016311 209 0.011
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.011
protein localization to plasma membrane GO:0072659 93 0.011
cellular metal ion homeostasis GO:0006875 146 0.011
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.011
sex differentiation GO:0007548 45 0.011
positive regulation of secretion GO:0051047 116 0.011
regulation of response to external stimulus GO:0032101 222 0.011
chemical homeostasis GO:0048878 306 0.011
cation homeostasis GO:0055080 189 0.011
regulation of chromosome organization GO:0033044 103 0.011
negative regulation of cell growth GO:0030308 83 0.011
regulation of nucleotide metabolic process GO:0006140 269 0.011
striated muscle contraction GO:0006941 52 0.011
platelet activation GO:0030168 44 0.010
compound eye development GO:0048749 1 0.010
actin filament based process GO:0030029 224 0.010
regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 24 0.010
single organism reproductive process GO:0044702 98 0.010
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.010
negative regulation of cell cycle phase transition GO:1901988 89 0.010
regulation of cell growth GO:0001558 135 0.010
reproductive system development GO:0061458 56 0.010
regulation of cell cycle phase transition GO:1901987 126 0.010
negative regulation of response to external stimulus GO:0032102 83 0.010
nucleoside phosphate catabolic process GO:1901292 412 0.010
cellular amine metabolic process GO:0044106 41 0.010
mitotic cell cycle phase transition GO:0044772 162 0.010

GPX4 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.044
cancer DOID:162 167 0.019
disease of cellular proliferation DOID:14566 174 0.019
disease of mental health DOID:150 70 0.013
central nervous system disease DOID:331 186 0.012
nervous system disease DOID:863 431 0.012
sensory system disease DOID:0050155 203 0.011
eye and adnexa disease DOID:1492 150 0.011
eye disease DOID:5614 149 0.011