Homo sapiens

53 known processes

H3F3A

H3 histone, family 3A

(Aliases: MGC87783,MGC87782,H3F3,H3F3B,H3.3A)

H3F3A biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
nucleosome organization GO:0034728 66 0.975
dna replication independent nucleosome organization GO:0034724 27 0.968
nucleosome assembly GO:0006334 50 0.962
chromatin organization GO:0006325 351 0.962
chromatin assembly or disassembly GO:0006333 78 0.941
chromatin assembly GO:0031497 61 0.833
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.784
chromatin modification GO:0016568 298 0.756
protein dna complex subunit organization GO:0071824 80 0.616
dna replication independent nucleosome assembly GO:0006336 27 0.581
dna conformation change GO:0071103 113 0.555
protein dna complex assembly GO:0065004 64 0.511
dna replication dependent nucleosome assembly GO:0006335 32 0.470
Human
covalent chromatin modification GO:0016569 254 0.410
histone modification GO:0016570 251 0.298
dna packaging GO:0006323 77 0.284
positive regulation of cellular amine metabolic process GO:0033240 7 0.224
protein modification by small protein conjugation GO:0032446 342 0.215
cellular ketone metabolic process GO:0042180 80 0.209
chromatin remodeling GO:0006338 55 0.200
cellular macromolecular complex assembly GO:0034622 324 0.163
cellular amino acid metabolic process GO:0006520 116 0.163
macromolecule methylation GO:0043414 97 0.153
peptidyl lysine modification GO:0018205 144 0.148
regulation of cellular amine metabolic process GO:0033238 11 0.144
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.140
regulation of cellular ketone metabolic process GO:0010565 50 0.134
immune system development GO:0002520 195 0.126
amine metabolic process GO:0009308 44 0.123
dna replication dependent nucleosome organization GO:0034723 32 0.122
Human
negative regulation of cell death GO:0060548 345 0.118
negative regulation of apoptotic process GO:0043066 316 0.115
cellular amine metabolic process GO:0044106 41 0.111
regulation of cellular amino acid metabolic process GO:0006521 6 0.107
myeloid cell differentiation GO:0030099 117 0.105
cellular response to dna damage stimulus GO:0006974 379 0.094
dna replication GO:0006260 116 0.088
female gamete generation GO:0007292 2 0.078
regulation of cell differentiation GO:0045595 393 0.078
positive regulation of organelle organization GO:0010638 195 0.075
positive regulation of developmental process GO:0051094 314 0.074
cellular response to endogenous stimulus GO:0071495 336 0.072
methylation GO:0032259 106 0.070
positive regulation of cellular component organization GO:0051130 376 0.070
histone lysine methylation GO:0034968 50 0.066
regulation of cellular component biogenesis GO:0044087 281 0.064
hematopoietic or lymphoid organ development GO:0048534 186 0.063
protein acetylation GO:0006473 116 0.061
protein alkylation GO:0008213 74 0.061
regulation of cell cycle process GO:0010564 266 0.060
immune response GO:0006955 307 0.058
histone methylation GO:0016571 60 0.057
regulation of chromatin organization GO:1902275 56 0.055
multicellular organismal aging GO:0010259 3 0.053
Worm
protein ubiquitination GO:0016567 314 0.053
negative regulation of phosphorus metabolic process GO:0010563 267 0.053
biological adhesion GO:0022610 331 0.052
Fly
regulation of cell cycle GO:0051726 393 0.052
oogenesis GO:0048477 2 0.051
negative regulation of cell differentiation GO:0045596 171 0.050
positive regulation of cell proliferation GO:0008284 301 0.047
negative regulation of apoptotic signaling pathway GO:2001234 97 0.047
defense response GO:0006952 315 0.046
negative regulation of multicellular organismal process GO:0051241 317 0.046
apoptotic signaling pathway GO:0097190 268 0.045
negative regulation of intracellular signal transduction GO:1902532 183 0.044
cellular response to oxygen containing compound GO:1901701 276 0.044
mitotic cell cycle GO:0000278 326 0.044
osteoblast differentiation GO:0001649 92 0.043
hemopoiesis GO:0030097 180 0.043
negative regulation of cell cycle GO:0045786 193 0.041
negative regulation of protein metabolic process GO:0051248 391 0.040
negative regulation of phosphate metabolic process GO:0045936 267 0.040
response to other organism GO:0051707 261 0.039
ameboidal type cell migration GO:0001667 135 0.039
negative regulation of programmed cell death GO:0043069 321 0.039
cell projection organization GO:0030030 252 0.039
response to oxygen containing compound GO:1901700 369 0.038
protein acylation GO:0043543 138 0.037
protein methylation GO:0006479 74 0.037
ossification GO:0001503 121 0.037
vasculature development GO:0001944 181 0.037
nervous system development GO:0007399 293 0.037
cell cycle phase transition GO:0044770 173 0.036
intracellular protein transport GO:0006886 270 0.035
negative regulation of cellular protein metabolic process GO:0032269 353 0.035
carbohydrate derivative biosynthetic process GO:1901137 207 0.034
negative regulation of cell cycle phase transition GO:1901988 89 0.034
hematopoietic progenitor cell differentiation GO:0002244 38 0.034
protein localization to organelle GO:0033365 280 0.034
positive regulation of apoptotic process GO:0043065 246 0.034
regulation of protein kinase activity GO:0045859 289 0.033
response to cytokine GO:0034097 232 0.033
positive regulation of phosphorylation GO:0042327 394 0.033
cell development GO:0048468 328 0.033
signal transduction by phosphorylation GO:0023014 297 0.032
cell morphogenesis GO:0000902 296 0.032
Fly
response to biotic stimulus GO:0009607 276 0.032
regulation of peptidase activity GO:0052547 180 0.032
cardiovascular system development GO:0072358 262 0.032
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.031
enzyme linked receptor protein signaling pathway GO:0007167 303 0.031
protein oligomerization GO:0051259 173 0.031
cellular macromolecule catabolic process GO:0044265 380 0.031
negative regulation of phosphorylation GO:0042326 174 0.031
regulation of dna metabolic process GO:0051052 153 0.031
muscle structure development GO:0061061 98 0.031
positive regulation of cellular component biogenesis GO:0044089 158 0.030
cellular component morphogenesis GO:0032989 314 0.030
Fly
positive regulation of chromatin modification GO:1903310 30 0.030
reproductive process GO:0022414 106 0.030
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.029
gene silencing GO:0016458 49 0.029
Human
post embryonic development GO:0009791 2 0.029
Worm
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.029
positive regulation of protein phosphorylation GO:0001934 313 0.028
regulation of myeloid cell differentiation GO:0045637 81 0.028
regulation of chromatin modification GO:1903308 51 0.028
cell adhesion GO:0007155 325 0.027
Fly
regulation of kinase activity GO:0043549 314 0.027
megakaryocyte differentiation GO:0030219 25 0.027
growth GO:0040007 202 0.027
atp dependent chromatin remodeling GO:0043044 25 0.027
response to growth factor GO:0070848 205 0.027
regulation of transferase activity GO:0051338 355 0.027
regulation of gene expression epigenetic GO:0040029 73 0.026
regulation of mitotic cell cycle phase transition GO:1901990 118 0.026
ribonucleoside monophosphate metabolic process GO:0009161 187 0.026
spermatid differentiation GO:0048515 4 0.026
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.026
neurogenesis GO:0022008 169 0.026
response to external biotic stimulus GO:0043207 261 0.026
purine nucleoside monophosphate metabolic process GO:0009126 186 0.026
mapk cascade GO:0000165 288 0.025
negative regulation of catalytic activity GO:0043086 335 0.025
nucleoside triphosphate metabolic process GO:0009141 422 0.025
positive regulation of cell death GO:0010942 263 0.025
mitotic cell cycle process GO:1903047 286 0.025
interspecies interaction between organisms GO:0044419 156 0.025
reactive oxygen species metabolic process GO:0072593 75 0.025
negative regulation of cell cycle process GO:0010948 121 0.025
system process GO:0003008 349 0.025
regulation of mitotic cell cycle GO:0007346 189 0.024
gastrulation GO:0007369 51 0.024
mitotic cell cycle phase transition GO:0044772 162 0.024
positive regulation of programmed cell death GO:0043068 249 0.024
cell growth GO:0016049 160 0.024
dna repair GO:0006281 198 0.024
ribonucleoside monophosphate catabolic process GO:0009158 158 0.024
negative regulation of protein modification process GO:0031400 200 0.024
positive regulation of kinase activity GO:0033674 204 0.024
regulation of proteolysis GO:0030162 293 0.023
blood vessel morphogenesis GO:0048514 162 0.023
cell projection morphogenesis GO:0048858 129 0.023
purine nucleoside monophosphate catabolic process GO:0009128 158 0.023
response to inorganic substance GO:0010035 127 0.023
peptidyl lysine acetylation GO:0018394 101 0.023
memory GO:0007613 3 0.023
cytoplasmic transport GO:0016482 379 0.023
regulation of cellular response to stress GO:0080135 244 0.023
epithelium migration GO:0090132 119 0.023
regulation of apoptotic signaling pathway GO:2001233 175 0.023
neuron differentiation GO:0030182 138 0.023
nucleoside monophosphate catabolic process GO:0009125 159 0.023
negative regulation of mitotic cell cycle GO:0045930 102 0.023
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.023
cellular homeostasis GO:0019725 196 0.022
transcription elongation from rna polymerase ii promoter GO:0006368 18 0.022
response to organic cyclic compound GO:0014070 204 0.022
intracellular receptor signaling pathway GO:0030522 104 0.022
cellular response to cytokine stimulus GO:0071345 181 0.022
anatomical structure homeostasis GO:0060249 100 0.022
cytokine production GO:0001816 247 0.022
viral life cycle GO:0019058 132 0.022
ribonucleotide catabolic process GO:0009261 405 0.022
regulation of cell cycle phase transition GO:1901987 126 0.022
negative regulation of cell proliferation GO:0008285 228 0.022
ribonucleoside triphosphate metabolic process GO:0009199 412 0.021
positive regulation of protein kinase activity GO:0045860 190 0.021
regulation of chromosome organization GO:0033044 103 0.021
regeneration GO:0031099 4 0.021
posttranscriptional regulation of gene expression GO:0010608 213 0.021
multi organism cellular process GO:0044764 156 0.021
response to lipid GO:0033993 206 0.021
response to hormone GO:0009725 175 0.021
regulation of multi organism process GO:0043900 157 0.021
regulation of histone modification GO:0031056 47 0.021
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.021
histone acetylation GO:0016573 93 0.021
regulation of anatomical structure morphogenesis GO:0022603 286 0.021
Fly
protein catabolic process GO:0030163 325 0.021
cellular response to growth factor stimulus GO:0071363 197 0.021
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.020
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.020
organophosphate biosynthetic process GO:0090407 163 0.020
atp metabolic process GO:0046034 176 0.020
protein complex disassembly GO:0043241 52 0.020
ion homeostasis GO:0050801 230 0.020
positive regulation of transport GO:0051050 336 0.020
positive regulation of transferase activity GO:0051347 227 0.020
innate immune response GO:0045087 178 0.020
dna templated transcription elongation GO:0006354 25 0.020
behavior GO:0007610 112 0.019
spermatid development GO:0007286 4 0.019
determination of adult lifespan GO:0008340 2 0.019
Worm
circulatory system development GO:0072359 262 0.019
nuclear transport GO:0051169 179 0.019
cellular component disassembly GO:0022411 92 0.019
ribonucleoside catabolic process GO:0042454 406 0.019
purine ribonucleoside metabolic process GO:0046128 437 0.019
regulation of endopeptidase activity GO:0052548 170 0.019
regulation of cellular component movement GO:0051270 334 0.019
tube morphogenesis GO:0035239 95 0.018
positive regulation of cell cycle GO:0045787 140 0.018
protein targeting GO:0006605 187 0.018
segmentation GO:0035282 4 0.018
negative regulation of megakaryocyte differentiation GO:0045653 16 0.018
negative regulation of organelle organization GO:0010639 126 0.018
nucleoside phosphate catabolic process GO:1901292 412 0.018
rna splicing GO:0008380 131 0.018
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.018
neuron projection development GO:0031175 106 0.018
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.018
single organism cellular localization GO:1902580 332 0.018
regulation of intracellular transport GO:0032386 195 0.017
nucleoside phosphate biosynthetic process GO:1901293 109 0.017
organonitrogen compound biosynthetic process GO:1901566 200 0.017
purine ribonucleoside catabolic process GO:0046130 398 0.017
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 52 0.017
carbohydrate metabolic process GO:0005975 207 0.017
small gtpase mediated signal transduction GO:0007264 78 0.017
regulation of cell migration GO:0030334 289 0.017
regulation of growth GO:0040008 165 0.017
mitotic cell cycle checkpoint GO:0007093 68 0.017
chemical homeostasis GO:0048878 306 0.017
regulation of protein ubiquitination GO:0031396 95 0.017
vesicle mediated transport GO:0016192 371 0.017
cellular response to nitrogen compound GO:1901699 144 0.017
purine nucleoside triphosphate catabolic process GO:0009146 392 0.016
cellular response to oxidative stress GO:0034599 85 0.016
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 0.016
nucleoside catabolic process GO:0009164 408 0.016
chromatin silencing GO:0006342 12 0.016
cell part morphogenesis GO:0032990 137 0.016
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.016
nucleoside monophosphate metabolic process GO:0009123 191 0.016
anatomical structure formation involved in morphogenesis GO:0048646 284 0.016
regulation of mapk cascade GO:0043408 262 0.016
regulation of cytoplasmic transport GO:1903649 149 0.016
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.016
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.016
regulation of protein stability GO:0031647 87 0.015
blood vessel development GO:0001568 172 0.015
ribonucleoside triphosphate catabolic process GO:0009203 391 0.015
regulation of cell growth GO:0001558 135 0.015
neuromuscular junction development GO:0007528 3 0.015
dna integrity checkpoint GO:0031570 71 0.015
regulation of dna templated transcription elongation GO:0032784 23 0.015
compound eye development GO:0048749 1 0.015
establishment of protein localization to organelle GO:0072594 172 0.015
cell activation GO:0001775 213 0.015
neuron projection morphogenesis GO:0048812 50 0.015
single organism cell adhesion GO:0098602 179 0.015
negative regulation of protein maturation GO:1903318 142 0.015
maintenance of location GO:0051235 112 0.015
regulation of establishment of protein localization GO:0070201 242 0.014
regulation of response to external stimulus GO:0032101 222 0.014
positive regulation of hydrolase activity GO:0051345 331 0.014
regulation of cytoskeleton organization GO:0051493 177 0.014
regulation of protein complex assembly GO:0043254 147 0.014
regulation of protein transport GO:0051223 213 0.014
hindbrain development GO:0030902 3 0.014
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.014
response to abiotic stimulus GO:0009628 336 0.014
internal protein amino acid acetylation GO:0006475 101 0.014
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.014
cell division GO:0051301 168 0.014
digestive tract morphogenesis GO:0048546 56 0.014
nucleotide biosynthetic process GO:0009165 109 0.014
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.014
response to decreased oxygen levels GO:0036293 96 0.014
associative learning GO:0008306 1 0.014
renal system development GO:0072001 63 0.014
positive regulation of cell cycle process GO:0090068 106 0.014
blastoderm segmentation GO:0007350 2 0.014
negative regulation of catabolic process GO:0009895 104 0.014
negative regulation of protein processing GO:0010955 142 0.014
extrinsic apoptotic signaling pathway GO:0097191 119 0.014
muscle organ development GO:0007517 56 0.014
proteasomal protein catabolic process GO:0010498 176 0.014
purine ribonucleotide catabolic process GO:0009154 404 0.014
regulation of protein maturation GO:1903317 150 0.014
positive regulation of cell differentiation GO:0045597 211 0.014
regulation of protein catabolic process GO:0042176 155 0.014
regulation of cell division GO:0051302 116 0.013
cellular protein catabolic process GO:0044257 261 0.013
purine containing compound catabolic process GO:0072523 411 0.013
single organism reproductive process GO:0044702 98 0.013
regulation of anatomical structure size GO:0090066 101 0.013
positive regulation of histone modification GO:0031058 29 0.013
response to wounding GO:0009611 168 0.013
protein processing GO:0016485 226 0.013
negative regulation of hydrolase activity GO:0051346 182 0.013
regulation of protein localization GO:0032880 296 0.013
negative regulation of dna metabolic process GO:0051053 57 0.013
cation transport GO:0006812 331 0.013
response to hypoxia GO:0001666 96 0.013
nucleotide catabolic process GO:0009166 408 0.013
mrna metabolic process GO:0016071 175 0.013
positive regulation of proteolysis GO:0045862 142 0.013
response to alcohol GO:0097305 64 0.013
protein localization to nucleus GO:0034504 136 0.013
embryo development GO:0009790 123 0.013
Worm
positive regulation of growth GO:0045927 58 0.013
peripheral nervous system development GO:0007422 2 0.013
negative regulation of growth GO:0045926 97 0.013
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.013
embryonic morphogenesis GO:0048598 85 0.013
negative regulation of transferase activity GO:0051348 124 0.013
head development GO:0060322 108 0.013
negative regulation of immune system process GO:0002683 136 0.013
response to transforming growth factor beta GO:0071559 94 0.012
single organism carbohydrate metabolic process GO:0044723 193 0.012
regulation of defense response GO:0031347 154 0.012
regulation of protein processing GO:0070613 150 0.012
internal peptidyl lysine acetylation GO:0018393 97 0.012
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.012
neural tube formation GO:0001841 3 0.012
regulation of protein targeting GO:1903533 91 0.012
positive regulation of protein complex assembly GO:0031334 86 0.012
regulation of angiogenesis GO:0045765 92 0.012
protein maturation GO:0051604 233 0.012
cell cycle g1 s phase transition GO:0044843 80 0.012
cell morphogenesis involved in differentiation GO:0000904 144 0.012
regulation of hematopoietic progenitor cell differentiation GO:1901532 24 0.012
generation of neurons GO:0048699 152 0.012
glycoprotein metabolic process GO:0009100 110 0.012
positive regulation of cellular component movement GO:0051272 181 0.012
actin filament based process GO:0030029 224 0.012
nucleocytoplasmic transport GO:0006913 176 0.012
regulation of cell adhesion GO:0030155 166 0.012
modification dependent protein catabolic process GO:0019941 209 0.012
ras protein signal transduction GO:0007265 73 0.012
locomotory behavior GO:0007626 1 0.012
positive regulation of peptidase activity GO:0010952 88 0.012
viral process GO:0016032 146 0.012
response to oxygen levels GO:0070482 100 0.012
positive regulation of immune system process GO:0002684 283 0.012
positive regulation of cellular catabolic process GO:0031331 284 0.012
t cell activation GO:0042110 99 0.012
cellular ion homeostasis GO:0006873 168 0.012
cellular cation homeostasis GO:0030003 163 0.012
regulation of dephosphorylation GO:0035303 96 0.012
brain development GO:0007420 97 0.012
anterior posterior axis specification GO:0009948 2 0.012
epithelial cell migration GO:0010631 119 0.012
dna damage checkpoint GO:0000077 68 0.012
tissue migration GO:0090130 119 0.012
ribose phosphate biosynthetic process GO:0046390 82 0.012
nitrogen compound transport GO:0071705 191 0.012
glycosyl compound catabolic process GO:1901658 413 0.012
positive regulation of catabolic process GO:0009896 310 0.012
cellular response to lipid GO:0071396 127 0.011
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.011
positive regulation of nucleotide metabolic process GO:0045981 230 0.011
regulation of translation GO:0006417 89 0.011
embryonic organ development GO:0048568 36 0.011
homeostasis of number of cells GO:0048872 40 0.011
i kappab kinase nf kappab signaling GO:0007249 166 0.011
cell fate determination GO:0001709 3 0.011
response to metal ion GO:0010038 84 0.011
macromolecular complex disassembly GO:0032984 60 0.011
regulation of cell development GO:0060284 161 0.011
protein homooligomerization GO:0051260 100 0.011
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.011
negative regulation of kinase activity GO:0033673 106 0.011
positive regulation of dna metabolic process GO:0051054 73 0.011
negative regulation of cellular component organization GO:0051129 235 0.011
oocyte development GO:0048599 1 0.011
cellular protein complex assembly GO:0043623 188 0.011
protein import GO:0017038 130 0.011
divalent inorganic cation transport GO:0072511 158 0.011
protein polyubiquitination GO:0000209 110 0.011
regulation of neurogenesis GO:0050767 82 0.011
regulation of dna replication GO:0006275 68 0.011
regulation of osteoblast differentiation GO:0045667 38 0.011
response to bacterium GO:0009617 144 0.011
regulation of secretion by cell GO:1903530 177 0.011
positive regulation of endopeptidase activity GO:0010950 84 0.011
dephosphorylation GO:0016311 209 0.011
regulation of secretion GO:0051046 194 0.011
endocytosis GO:0006897 159 0.011
negative regulation of proteolysis GO:0045861 132 0.011
positive regulation of cell growth GO:0030307 48 0.011
cellular response to hormone stimulus GO:0032870 125 0.011
angiogenesis GO:0001525 147 0.011
negative regulation of myeloid cell differentiation GO:0045638 42 0.011
epithelium development GO:0060429 227 0.011
nerve development GO:0021675 4 0.011
response to oxidative stress GO:0006979 121 0.011
nuclear import GO:0051170 106 0.011
cell morphogenesis involved in neuron differentiation GO:0048667 44 0.011
embryonic placenta development GO:0001892 1 0.011
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.011
regulation of neural precursor cell proliferation GO:2000177 4 0.010
negative regulation of protein kinase activity GO:0006469 98 0.010
endochondral bone morphogenesis GO:0060350 3 0.010
translation GO:0006412 132 0.010
epithelial cell differentiation GO:0030855 141 0.010
limbic system development GO:0021761 3 0.010
purine nucleotide biosynthetic process GO:0006164 84 0.010
central nervous system development GO:0007417 123 0.010
metal ion transport GO:0030001 272 0.010
negative regulation of multi organism process GO:0043901 92 0.010
positive regulation of chromosome organization GO:2001252 41 0.010
regulation of nucleocytoplasmic transport GO:0046822 98 0.010
lymphocyte activation GO:0046649 133 0.010
stress activated protein kinase signaling cascade GO:0031098 94 0.010
meiosis i GO:0007127 4 0.010
ion transmembrane transport GO:0034220 338 0.010
cell cell signaling GO:0007267 155 0.010
neuron development GO:0048666 113 0.010
cellular response to reactive oxygen species GO:0034614 50 0.010
rna processing GO:0006396 255 0.010
response to nitrogen compound GO:1901698 184 0.010
metencephalon development GO:0022037 2 0.010
organelle assembly GO:0070925 176 0.010
mitotic dna integrity checkpoint GO:0044774 30 0.010

H3F3A disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.015
cancer DOID:162 167 0.015
disease of cellular proliferation DOID:14566 174 0.015
organ system cancer DOID:0050686 164 0.015
central nervous system disease DOID:331 186 0.013
nervous system disease DOID:863 431 0.013