|
|
negative regulation of extrinsic apoptotic signaling pathway
|
GO:2001237 |
52 |
0.984
|
Human |
|
|
actin filament organization
|
GO:0007015 |
128 |
0.983
|
Human Fly |
|
|
actin filament based process
|
GO:0030029 |
224 |
0.977
|
|
|
|
positive regulation of immune system process
|
GO:0002684 |
283 |
0.971
|
Human |
|
|
cytokine production
|
GO:0001816 |
247 |
0.966
|
Human |
|
|
interferon gamma production
|
GO:0032609 |
39 |
0.956
|
Human |
|
|
vesicle mediated transport
|
GO:0016192 |
371 |
0.953
|
|
|
|
cellular response to transforming growth factor beta stimulus
|
GO:0071560 |
94 |
0.949
|
Human |
|
|
response to external biotic stimulus
|
GO:0043207 |
261 |
0.939
|
Mouse |
|
|
regulation of cytokine production
|
GO:0001817 |
232 |
0.934
|
Human |
|
|
regulation of actin cytoskeleton organization
|
GO:0032956 |
116 |
0.927
|
|
|
|
actin polymerization or depolymerization
|
GO:0008154 |
56 |
0.924
|
Fly |
|
|
positive regulation of lipid metabolic process
|
GO:0045834 |
50 |
0.920
|
Human |
|
|
regulation of cell migration
|
GO:0030334 |
289 |
0.915
|
Human |
|
|
activation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0006919 |
49 |
0.904
|
Human |
|
|
response to biotic stimulus
|
GO:0009607 |
276 |
0.899
|
Mouse |
|
|
response to other organism
|
GO:0051707 |
261 |
0.897
|
Mouse |
|
|
regulation of protein oligomerization
|
GO:0032459 |
26 |
0.882
|
Human |
|
|
cell activation
|
GO:0001775 |
213 |
0.878
|
Human |
|
|
integrin mediated signaling pathway
|
GO:0007229 |
32 |
0.875
|
Human |
|
|
caveolin mediated endocytosis
|
GO:0072584 |
4 |
0.869
|
Human |
|
|
positive regulation of response to interferon gamma
|
GO:0060332 |
2 |
0.868
|
Human |
|
|
memory
|
GO:0007613 |
3 |
0.863
|
Fly |
|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.860
|
Human Fly |
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
11 |
0.854
|
|
|
|
immune response regulating cell surface receptor signaling pathway
|
GO:0002768 |
51 |
0.841
|
Human |
|
|
actin cytoskeleton organization
|
GO:0030036 |
207 |
0.837
|
|
|
|
actin filament polymerization
|
GO:0030041 |
45 |
0.834
|
|
|
|
amide transport
|
GO:0042886 |
76 |
0.834
|
Human |
|
|
regulation of actin polymerization or depolymerization
|
GO:0008064 |
56 |
0.834
|
Fly |
|
|
zinc ion homeostasis
|
GO:0055069 |
12 |
0.824
|
Human |
|
|
leukocyte activation
|
GO:0045321 |
164 |
0.820
|
Human |
|
|
cellular amine metabolic process
|
GO:0044106 |
41 |
0.803
|
|
|
|
positive regulation of cell differentiation
|
GO:0045597 |
211 |
0.790
|
Human |
|
|
regulation of cellular component biogenesis
|
GO:0044087 |
281 |
0.790
|
|
|
|
negative regulation of peptidase activity
|
GO:0010466 |
91 |
0.786
|
Human |
|
|
tyrosine phosphorylation of stat3 protein
|
GO:0042503 |
20 |
0.773
|
Human |
|
|
defense response
|
GO:0006952 |
315 |
0.763
|
Human Mouse |
|
|
enzyme linked receptor protein signaling pathway
|
GO:0007167 |
303 |
0.754
|
Human |
|
|
lymphocyte activation
|
GO:0046649 |
133 |
0.749
|
Human |
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.747
|
|
|
|
regulation of extrinsic apoptotic signaling pathway
|
GO:2001236 |
85 |
0.745
|
Human |
|
|
positive regulation of cell motility
|
GO:2000147 |
177 |
0.741
|
|
|
|
regulation of leukocyte migration
|
GO:0002685 |
63 |
0.739
|
|
|
|
positive regulation of cytokine production
|
GO:0001819 |
167 |
0.737
|
Human |
|
|
regulation of cell motility
|
GO:2000145 |
299 |
0.736
|
Human |
|
|
t cell activation
|
GO:0042110 |
99 |
0.734
|
Human |
|
|
regulation of caveolin mediated endocytosis
|
GO:2001286 |
2 |
0.726
|
Human |
|
|
positive regulation of t cell activation
|
GO:0050870 |
54 |
0.723
|
Human |
|
|
cell chemotaxis
|
GO:0060326 |
112 |
0.722
|
|
|
|
positive regulation of apoptotic process
|
GO:0043065 |
246 |
0.717
|
Human |
|
|
positive regulation of cytoskeleton organization
|
GO:0051495 |
83 |
0.716
|
|
|
|
regulation of defense response
|
GO:0031347 |
154 |
0.713
|
Human |
|
|
endocytosis
|
GO:0006897 |
159 |
0.712
|
|
|
|
actin filament bundle assembly
|
GO:0051017 |
54 |
0.705
|
Human Fly |
|
|
jak stat cascade
|
GO:0007259 |
46 |
0.704
|
Human |
|
|
cellular response to cytokine stimulus
|
GO:0071345 |
181 |
0.701
|
Human |
|
|
peptide secretion
|
GO:0002790 |
51 |
0.700
|
Human |
|
|
leukocyte differentiation
|
GO:0002521 |
98 |
0.700
|
Human |
|
|
regulation of protein transport
|
GO:0051223 |
213 |
0.688
|
|
|
|
cell development
|
GO:0048468 |
328 |
0.678
|
Human Fly |
|
|
response to transforming growth factor beta
|
GO:0071559 |
94 |
0.673
|
Human |
|
|
secretion by cell
|
GO:0032940 |
226 |
0.669
|
Human |
|
|
regulation of nucleotide catabolic process
|
GO:0030811 |
205 |
0.668
|
|
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.663
|
Human |
|
|
regulation of protein complex assembly
|
GO:0043254 |
147 |
0.662
|
|
|
|
peptide transport
|
GO:0015833 |
74 |
0.660
|
Human |
|
|
hormone transport
|
GO:0009914 |
68 |
0.658
|
Human |
|
|
immune system development
|
GO:0002520 |
195 |
0.657
|
Human |
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.651
|
|
|
|
oogenesis
|
GO:0048477 |
2 |
0.641
|
Fly |
|
|
regulation of secretion by cell
|
GO:1903530 |
177 |
0.641
|
Human |
|
|
positive regulation of phosphatidylinositol 3 kinase signaling
|
GO:0014068 |
28 |
0.640
|
Human |
|
|
chemotaxis
|
GO:0006935 |
157 |
0.635
|
Fly |
|
|
extrinsic apoptotic signaling pathway
|
GO:0097191 |
119 |
0.634
|
Human |
|
|
positive regulation of interferon gamma production
|
GO:0032729 |
26 |
0.632
|
Human |
|
|
positive regulation of cell death
|
GO:0010942 |
263 |
0.628
|
Human |
|
|
negative regulation of cysteine type endopeptidase activity
|
GO:2000117 |
48 |
0.627
|
Human |
|
|
regulation of actin filament based process
|
GO:0032970 |
141 |
0.612
|
|
|
|
positive regulation of cell proliferation
|
GO:0008284 |
301 |
0.611
|
|
|
|
immune response regulating signaling pathway
|
GO:0002764 |
97 |
0.609
|
Human |
|
|
cellular ketone metabolic process
|
GO:0042180 |
80 |
0.603
|
|
|
|
hormone secretion
|
GO:0046879 |
65 |
0.594
|
Human |
|
|
positive regulation of cell activation
|
GO:0050867 |
81 |
0.583
|
Human |
|
|
positive regulation of cytokine mediated signaling pathway
|
GO:0001961 |
12 |
0.581
|
Human |
|
|
negative regulation of developmental process
|
GO:0051093 |
247 |
0.580
|
Fly |
|
|
regulation of lymphocyte activation
|
GO:0051249 |
103 |
0.572
|
Human |
|
|
single organismal cell cell adhesion
|
GO:0016337 |
148 |
0.571
|
Human Fly |
|
|
regulation of actin filament polymerization
|
GO:0030833 |
50 |
0.569
|
|
|
|
dephosphorylation
|
GO:0016311 |
209 |
0.566
|
Human |
|
|
cellular chemical homeostasis
|
GO:0055082 |
180 |
0.554
|
Human |
|
|
regulation of hormone secretion
|
GO:0046883 |
57 |
0.553
|
Human |
|
|
regulation of insulin secretion
|
GO:0050796 |
33 |
0.541
|
Human |
|
|
regulation of secretion
|
GO:0051046 |
194 |
0.540
|
Human |
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.534
|
Human |
|
|
myeloid leukocyte migration
|
GO:0097529 |
62 |
0.534
|
|
|
|
regulation of organelle assembly
|
GO:1902115 |
40 |
0.531
|
|
|
|
glycosyl compound catabolic process
|
GO:1901658 |
413 |
0.527
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.526
|
|
|
|
regulation of response to external stimulus
|
GO:0032101 |
222 |
0.524
|
|
|
|
negative regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043154 |
46 |
0.523
|
Human |
|
|
positive regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043280 |
69 |
0.522
|
Human |
|
|
cellular divalent inorganic cation homeostasis
|
GO:0072503 |
128 |
0.515
|
Human |
|
|
metal ion homeostasis
|
GO:0055065 |
169 |
0.514
|
Human |
|
|
regulation of mast cell degranulation
|
GO:0043304 |
3 |
0.506
|
|
|
|
regulation of anatomical structure size
|
GO:0090066 |
101 |
0.505
|
Fly |
|
|
cytokine mediated signaling pathway
|
GO:0019221 |
109 |
0.505
|
Human |
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.498
|
|
|
|
long term memory
|
GO:0007616 |
2 |
0.497
|
Fly |
|
|
positive regulation of proteolysis
|
GO:0045862 |
142 |
0.492
|
Human |
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
331 |
0.490
|
Human |
|
|
regulation of interferon gamma production
|
GO:0032649 |
36 |
0.488
|
Human |
|
|
positive regulation of intrinsic apoptotic signaling pathway
|
GO:2001244 |
28 |
0.484
|
Human |
|
|
cellular response to endogenous stimulus
|
GO:0071495 |
336 |
0.483
|
Human |
|
|
actin filament bundle organization
|
GO:0061572 |
54 |
0.480
|
Human Fly |
|
|
positive regulation of interferon gamma mediated signaling pathway
|
GO:0060335 |
2 |
0.475
|
Human |
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
6 |
0.475
|
|
|
|
granulocyte migration
|
GO:0097530 |
40 |
0.474
|
|
|
|
positive regulation of locomotion
|
GO:0040017 |
186 |
0.472
|
|
|
|
cellular transition metal ion homeostasis
|
GO:0046916 |
21 |
0.471
|
Human |
|
|
positive regulation of peptide secretion
|
GO:0002793 |
15 |
0.468
|
Human |
|
|
response to cytokine
|
GO:0034097 |
232 |
0.459
|
Human |
|
|
anatomical structure formation involved in morphogenesis
|
GO:0048646 |
284 |
0.456
|
Fly |
|
|
regulation of cellular component movement
|
GO:0051270 |
334 |
0.455
|
Human |
|
|
regulation of anatomical structure morphogenesis
|
GO:0022603 |
286 |
0.450
|
|
|
|
regulation of vesicle mediated transport
|
GO:0060627 |
130 |
0.445
|
|
|
|
early endosome to late endosome transport
|
GO:0045022 |
21 |
0.444
|
Human |
|
|
regulation of hormone levels
|
GO:0010817 |
125 |
0.441
|
Human |
|
|
cellular response to interferon gamma
|
GO:0071346 |
24 |
0.441
|
Human |
|
|
cellular cation homeostasis
|
GO:0030003 |
163 |
0.440
|
Human |
|
|
taxis
|
GO:0042330 |
157 |
0.436
|
Fly |
|
|
regulation of mitochondrial membrane potential
|
GO:0051881 |
23 |
0.432
|
Human |
|
|
negative regulation of mitochondrial depolarization
|
GO:0051902 |
2 |
0.432
|
Human |
|
|
immune response
|
GO:0006955 |
307 |
0.429
|
Human |
|
|
secretion
|
GO:0046903 |
254 |
0.428
|
Human |
|
|
response to oxygen containing compound
|
GO:1901700 |
369 |
0.408
|
Human |
|
|
regulation of proteolysis
|
GO:0030162 |
293 |
0.407
|
Human |
|
|
tyrosine phosphorylation of stat5 protein
|
GO:0042506 |
13 |
0.407
|
Human |
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.401
|
Human Fly |
|
|
regulation of intrinsic apoptotic signaling pathway
|
GO:2001242 |
72 |
0.399
|
Human |
|
|
hemopoiesis
|
GO:0030097 |
180 |
0.395
|
Human |
|
|
defense response to other organism
|
GO:0098542 |
129 |
0.388
|
Mouse |
|
|
positive regulation of cysteine type endopeptidase activity
|
GO:2001056 |
79 |
0.388
|
Human |
|
|
regulation of leukocyte proliferation
|
GO:0070663 |
67 |
0.388
|
|
|
|
leukocyte migration
|
GO:0050900 |
107 |
0.385
|
|
|
|
response to interferon gamma
|
GO:0034341 |
39 |
0.385
|
Human |
|
|
positive regulation of hormone secretion
|
GO:0046887 |
25 |
0.384
|
Human |
|
|
membrane organization
|
GO:0061024 |
292 |
0.384
|
|
|
|
protein oligomerization
|
GO:0051259 |
173 |
0.383
|
Human |
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
175 |
0.381
|
Human |
|
|
response to lipid
|
GO:0033993 |
206 |
0.380
|
Human |
|
|
regulation of intracellular transport
|
GO:0032386 |
195 |
0.377
|
Human |
|
|
response to bacterium
|
GO:0009617 |
144 |
0.377
|
Mouse |
|
|
cellular zinc ion homeostasis
|
GO:0006882 |
10 |
0.376
|
Human |
|
|
positive regulation of secretion by cell
|
GO:1903532 |
108 |
0.375
|
Human |
|
|
positive regulation of leukocyte activation
|
GO:0002696 |
80 |
0.373
|
Human |
|
|
biological adhesion
|
GO:0022610 |
331 |
0.372
|
Human Fly |
|
|
stress fiber assembly
|
GO:0043149 |
40 |
0.371
|
Human |
|
|
cell adhesion
|
GO:0007155 |
325 |
0.370
|
Human Fly |
|
|
cellular homeostasis
|
GO:0019725 |
196 |
0.369
|
Human |
|
|
negative regulation of cellular amine metabolic process
|
GO:0033239 |
3 |
0.369
|
|
|
|
mapk cascade
|
GO:0000165 |
288 |
0.368
|
|
|
|
regulation of cysteine type endopeptidase activity
|
GO:2000116 |
127 |
0.367
|
Human |
|
|
regulation of cytoskeleton organization
|
GO:0051493 |
177 |
0.362
|
|
|
|
regulation of endopeptidase activity
|
GO:0052548 |
170 |
0.359
|
Human |
|
|
positive regulation of peptide hormone secretion
|
GO:0090277 |
15 |
0.358
|
Human |
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.358
|
Human |
|
|
positive regulation of cellular component organization
|
GO:0051130 |
376 |
0.357
|
|
|
|
peptide hormone secretion
|
GO:0030072 |
50 |
0.356
|
Human |
|
|
small gtpase mediated signal transduction
|
GO:0007264 |
78 |
0.354
|
|
|
|
positive regulation of endopeptidase activity
|
GO:0010950 |
84 |
0.348
|
Human |
|
|
positive regulation of programmed cell death
|
GO:0043068 |
249 |
0.348
|
Human |
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.348
|
|
|
|
regulation of membrane depolarization
|
GO:0003254 |
19 |
0.345
|
Human |
|
|
regulation of cytokine mediated signaling pathway
|
GO:0001959 |
41 |
0.344
|
Human |
|
|
positive regulation of secretion
|
GO:0051047 |
116 |
0.340
|
Human |
|
|
negative regulation of proteolysis
|
GO:0045861 |
132 |
0.339
|
Human |
|
|
mononuclear cell proliferation
|
GO:0032943 |
71 |
0.335
|
|
|
|
myeloid cell differentiation
|
GO:0030099 |
117 |
0.333
|
|
|
|
positive regulation of t cell proliferation
|
GO:0042102 |
33 |
0.332
|
|
|
|
positive regulation of leukocyte chemotaxis
|
GO:0002690 |
38 |
0.329
|
|
|
|
interferon gamma mediated signaling pathway
|
GO:0060333 |
7 |
0.326
|
Human |
|
|
system process
|
GO:0003008 |
349 |
0.326
|
Fly |
|
|
positive regulation of response to cytokine stimulus
|
GO:0060760 |
13 |
0.320
|
Human |
|
|
positive regulation of cellular component biogenesis
|
GO:0044089 |
158 |
0.319
|
|
|
|
neurological system process
|
GO:0050877 |
163 |
0.318
|
Fly |
|
|
organ morphogenesis
|
GO:0009887 |
147 |
0.315
|
Fly |
|
|
negative regulation of cellular component organization
|
GO:0051129 |
235 |
0.315
|
Human Fly |
|
|
immune effector process
|
GO:0002252 |
159 |
0.314
|
|
|
|
regulation of immune response
|
GO:0050776 |
201 |
0.311
|
Human |
|
|
purine ribonucleoside triphosphate catabolic process
|
GO:0009207 |
391 |
0.309
|
|
|
|
positive regulation of peptidase activity
|
GO:0010952 |
88 |
0.306
|
Human |
|
|
cellular macromolecular complex assembly
|
GO:0034622 |
324 |
0.305
|
|
|
|
regulation of protein processing
|
GO:0070613 |
150 |
0.305
|
Human |
|
|
cell projection organization
|
GO:0030030 |
252 |
0.305
|
Human Fly |
|
|
regulation of ion homeostasis
|
GO:2000021 |
73 |
0.300
|
Human |
|
|
positive regulation of gtp catabolic process
|
GO:0033126 |
166 |
0.300
|
|
|
|
regulation of cell development
|
GO:0060284 |
161 |
0.300
|
Human |
|
|
cellular ion homeostasis
|
GO:0006873 |
168 |
0.298
|
Human |
|
|
regulation of lymphocyte proliferation
|
GO:0050670 |
64 |
0.295
|
|
|
|
plasma membrane organization
|
GO:0007009 |
115 |
0.294
|
|
|
|
cellular lipid metabolic process
|
GO:0044255 |
303 |
0.291
|
Human |
|
|
divalent inorganic cation homeostasis
|
GO:0072507 |
136 |
0.291
|
Human |
|
|
regulation of peptidase activity
|
GO:0052547 |
180 |
0.290
|
Human |
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.290
|
|
|
|
apoptotic signaling pathway
|
GO:0097190 |
268 |
0.284
|
Human |
|
|
negative regulation of apoptotic signaling pathway
|
GO:2001234 |
97 |
0.283
|
Human |
|
|
purine nucleoside catabolic process
|
GO:0006152 |
398 |
0.280
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.276
|
Human Fly |
|
|
purine nucleoside triphosphate catabolic process
|
GO:0009146 |
392 |
0.276
|
|
|
|
protein kinase b signaling
|
GO:0043491 |
69 |
0.275
|
Human |
|
|
regulation of innate immune response
|
GO:0045088 |
97 |
0.273
|
Human |
|
|
negative regulation of protein oligomerization
|
GO:0032460 |
8 |
0.272
|
Human |
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.272
|
|
|
|
regulation of leukocyte activation
|
GO:0002694 |
115 |
0.271
|
Human |
|
|
defense response to bacterium
|
GO:0042742 |
63 |
0.270
|
Mouse |
|
|
regulation of t cell activation
|
GO:0050863 |
77 |
0.270
|
Human |
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
7 |
0.269
|
|
|
|
regulation of peptide hormone secretion
|
GO:0090276 |
41 |
0.268
|
Human |
|
|
regulation of lipid kinase activity
|
GO:0043550 |
19 |
0.266
|
Human |
|
|
positive regulation of immune response
|
GO:0050778 |
159 |
0.265
|
Human |
|
|
endodermal cell fate commitment
|
GO:0001711 |
4 |
0.262
|
|
|
|
lymphocyte differentiation
|
GO:0030098 |
35 |
0.261
|
Human |
|
|
regulation of nucleoside metabolic process
|
GO:0009118 |
209 |
0.259
|
|
|
|
immune response activating signal transduction
|
GO:0002757 |
90 |
0.258
|
Human |
|
|
regulation of actin filament length
|
GO:0030832 |
56 |
0.256
|
Fly |
|
|
negative regulation of cell proliferation
|
GO:0008285 |
228 |
0.255
|
|
|
|
regulation of cytokine secretion
|
GO:0050707 |
57 |
0.255
|
|
|
|
regulation of protein secretion
|
GO:0050708 |
86 |
0.253
|
|
|
|
negative regulation of protein homooligomerization
|
GO:0032463 |
4 |
0.252
|
Human |
|
|
regulation of response to cytokine stimulus
|
GO:0060759 |
46 |
0.252
|
Human |
|
|
regulation of membrane potential
|
GO:0042391 |
95 |
0.249
|
Human |
|
|
regulation of cell activation
|
GO:0050865 |
125 |
0.248
|
Human |
|
|
positive regulation of lipid kinase activity
|
GO:0090218 |
13 |
0.245
|
Human |
|
|
positive regulation of rho gtpase activity
|
GO:0032321 |
56 |
0.245
|
|
|
|
protein processing
|
GO:0016485 |
226 |
0.243
|
Human |
|
|
organophosphate catabolic process
|
GO:0046434 |
430 |
0.243
|
|
|
|
protein maturation
|
GO:0051604 |
233 |
0.243
|
Human |
|
|
positive regulation of cell migration
|
GO:0030335 |
172 |
0.242
|
|
|
|
regulation of myeloid leukocyte differentiation
|
GO:0002761 |
39 |
0.242
|
|
|
|
hematopoietic or lymphoid organ development
|
GO:0048534 |
186 |
0.235
|
Human |
|
|
zymogen activation
|
GO:0031638 |
70 |
0.234
|
Human |
|
|
positive regulation of defense response
|
GO:0031349 |
87 |
0.233
|
Human |
|
|
nitrogen compound transport
|
GO:0071705 |
191 |
0.232
|
Human |
|
|
insulin secretion
|
GO:0030073 |
39 |
0.231
|
Human |
|
|
cellular metal ion homeostasis
|
GO:0006875 |
146 |
0.226
|
Human |
|
|
regulation of mononuclear cell proliferation
|
GO:0032944 |
65 |
0.223
|
|
|
|
azole transport
|
GO:0045117 |
4 |
0.223
|
|
|
|
regulation of myeloid cell differentiation
|
GO:0045637 |
81 |
0.221
|
|
|
|
endodermal cell fate specification
|
GO:0001714 |
4 |
0.219
|
|
|
|
peptidyl tyrosine phosphorylation
|
GO:0018108 |
170 |
0.211
|
|
|
|
lipid metabolic process
|
GO:0006629 |
381 |
0.210
|
Human |
|
|
positive regulation of transport
|
GO:0051050 |
336 |
0.210
|
Human |
|
|
regulation of establishment of protein localization
|
GO:0070201 |
242 |
0.199
|
|
|
|
salivary gland morphogenesis
|
GO:0007435 |
4 |
0.197
|
Fly |
|
|
cytokine secretion
|
GO:0050663 |
64 |
0.196
|
|
|
|
positive regulation of actin cytoskeleton reorganization
|
GO:2000251 |
9 |
0.196
|
|
|
|
generation of neurons
|
GO:0048699 |
152 |
0.196
|
Human Fly |
|
|
exocytosis
|
GO:0006887 |
71 |
0.195
|
|
|
|
positive regulation of mapk cascade
|
GO:0043410 |
190 |
0.195
|
|
|
|
negative regulation of protein processing
|
GO:0010955 |
142 |
0.193
|
Human |
|
|
mitotic cell cycle
|
GO:0000278 |
326 |
0.193
|
|
|
|
gtp metabolic process
|
GO:0046039 |
239 |
0.193
|
|
|
|
regulation of nucleotide metabolic process
|
GO:0006140 |
269 |
0.193
|
|
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
313 |
0.191
|
Fly |
|
|
regulation of cell morphogenesis
|
GO:0022604 |
153 |
0.190
|
|
|
|
phosphatidylinositol 3 kinase signaling
|
GO:0014065 |
48 |
0.190
|
Human |
|
|
negative regulation of protein maturation
|
GO:1903318 |
142 |
0.189
|
Human |
|
|
innate immune response
|
GO:0045087 |
178 |
0.189
|
Human |
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
391 |
0.187
|
Human |
|
|
podosome assembly
|
GO:0071800 |
6 |
0.185
|
|
|
|
transition metal ion homeostasis
|
GO:0055076 |
31 |
0.185
|
Human |
|
|
response to growth factor
|
GO:0070848 |
205 |
0.181
|
Human |
|
|
g protein coupled receptor signaling pathway
|
GO:0007186 |
207 |
0.174
|
|
|
|
hepoxilin biosynthetic process
|
GO:0051122 |
1 |
0.172
|
|
|
|
ribonucleoside triphosphate metabolic process
|
GO:0009199 |
412 |
0.170
|
|
|
|
nucleotide catabolic process
|
GO:0009166 |
408 |
0.168
|
|
|
|
positive regulation of insulin secretion
|
GO:0032024 |
10 |
0.167
|
Human |
|
|
purine nucleoside triphosphate metabolic process
|
GO:0009144 |
412 |
0.165
|
|
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
127 |
0.165
|
Human |
|
|
positive regulation of peptidyl tyrosine phosphorylation
|
GO:0050731 |
85 |
0.162
|
|
|
|
positive regulation of protein complex assembly
|
GO:0031334 |
86 |
0.162
|
|
|
|
single organism membrane organization
|
GO:0044802 |
268 |
0.161
|
|
|
|
cell morphogenesis
|
GO:0000902 |
296 |
0.161
|
|
|
|
single organism cellular localization
|
GO:1902580 |
332 |
0.159
|
|
|
|
activation of cysteine type endopeptidase activity
|
GO:0097202 |
57 |
0.158
|
Human |
|
|
myoblast fusion
|
GO:0007520 |
1 |
0.158
|
|
|
|
negative regulation of hydrolase activity
|
GO:0051346 |
182 |
0.155
|
Human |
|
|
purine ribonucleoside catabolic process
|
GO:0046130 |
398 |
0.155
|
|
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
190 |
0.155
|
Fly |
|
|
regulation of locomotion
|
GO:0040012 |
329 |
0.155
|
Human |
|
|
regulation of small gtpase mediated signal transduction
|
GO:0051056 |
156 |
0.155
|
|
|
|
leukocyte proliferation
|
GO:0070661 |
74 |
0.154
|
|
|
|
positive regulation of lymphocyte proliferation
|
GO:0050671 |
46 |
0.154
|
|
|
|
cellular response to oxygen containing compound
|
GO:1901701 |
276 |
0.153
|
Human |
|
|
cell activation involved in immune response
|
GO:0002263 |
30 |
0.153
|
|
|
|
purine containing compound catabolic process
|
GO:0072523 |
411 |
0.152
|
|
|
|
positive regulation of lymphocyte activation
|
GO:0051251 |
73 |
0.152
|
Human |
|
|
regulation of phagocytosis
|
GO:0050764 |
21 |
0.150
|
|
|
|
purine ribonucleotide catabolic process
|
GO:0009154 |
404 |
0.149
|
|
|
|
ion homeostasis
|
GO:0050801 |
230 |
0.148
|
Human |
|
|
immune response activating cell surface receptor signaling pathway
|
GO:0002429 |
45 |
0.148
|
Human |
|
|
response to acid chemical
|
GO:0001101 |
66 |
0.146
|
Human |
|
|
digestive system development
|
GO:0055123 |
75 |
0.144
|
|
|
|
cytosolic calcium ion homeostasis
|
GO:0051480 |
89 |
0.142
|
|
|
|
regulation of phosphatidylinositol 3 kinase signaling
|
GO:0014066 |
35 |
0.142
|
Human |
|
|
adaptive immune response
|
GO:0002250 |
49 |
0.141
|
|
|
|
cytoplasmic transport
|
GO:0016482 |
379 |
0.141
|
Human |
|
|
regulation of purine nucleotide catabolic process
|
GO:0033121 |
205 |
0.140
|
|
|
|
heterotypic cell cell adhesion
|
GO:0034113 |
28 |
0.139
|
|
|
|
regulation of cell cell adhesion
|
GO:0022407 |
57 |
0.138
|
Human |
|
|
phospholipid metabolic process
|
GO:0006644 |
99 |
0.136
|
Human |
|
|
positive regulation of nucleotide catabolic process
|
GO:0030813 |
185 |
0.135
|
|
|
|
cation transport
|
GO:0006812 |
331 |
0.133
|
|
|
|
neuron projection development
|
GO:0031175 |
106 |
0.131
|
Human Fly |
|
|
intracellular protein transport
|
GO:0006886 |
270 |
0.130
|
|
|
|
positive regulation of catabolic process
|
GO:0009896 |
310 |
0.129
|
|
|
|
cation homeostasis
|
GO:0055080 |
189 |
0.129
|
Human |
|
|
actomyosin structure organization
|
GO:0031032 |
59 |
0.128
|
Human Fly |
|
|
response to fungus
|
GO:0009620 |
4 |
0.127
|
|
|
|
osteoclast development
|
GO:0036035 |
2 |
0.127
|
|
|
|
cellular response to lipid
|
GO:0071396 |
127 |
0.127
|
Human |
|
|
nucleoside triphosphate metabolic process
|
GO:0009141 |
422 |
0.127
|
|
|
|
regulation of endocytosis
|
GO:0030100 |
72 |
0.125
|
|
|
|
b cell receptor signaling pathway
|
GO:0050853 |
18 |
0.124
|
Human |
|
|
negative regulation of multicellular organismal process
|
GO:0051241 |
317 |
0.124
|
Fly |
|
|
positive regulation of vasoconstriction
|
GO:0045907 |
3 |
0.124
|
|
|
|
regulation of leukocyte chemotaxis
|
GO:0002688 |
46 |
0.123
|
|
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
140 |
0.123
|
Human |
|
|
negative regulation of programmed cell death
|
GO:0043069 |
321 |
0.122
|
|
|
|
regulation of leukocyte mediated immunity
|
GO:0002703 |
38 |
0.122
|
|
|
|
leukocyte mediated immunity
|
GO:0002443 |
59 |
0.122
|
|
|
|
response to abiotic stimulus
|
GO:0009628 |
336 |
0.121
|
|
|
|
endosomal transport
|
GO:0016197 |
129 |
0.120
|
Human |
|
|
organelle assembly
|
GO:0070925 |
176 |
0.118
|
|
|
|
lymphocyte proliferation
|
GO:0046651 |
70 |
0.117
|
|
|
|
positive regulation of membrane protein ectodomain proteolysis
|
GO:0051044 |
13 |
0.117
|
|
|
|
positive regulation of gtpase activity
|
GO:0043547 |
166 |
0.116
|
|
|
|
tube development
|
GO:0035295 |
125 |
0.115
|
|
|
|
t cell proliferation
|
GO:0042098 |
45 |
0.113
|
|
|
|
mast cell degranulation
|
GO:0043303 |
4 |
0.113
|
|
|
|
regulation of protein tyrosine kinase activity
|
GO:0061097 |
36 |
0.113
|
Human |
|
|
endomembrane system organization
|
GO:0010256 |
196 |
0.113
|
|
|
|
peptidyl tyrosine modification
|
GO:0018212 |
170 |
0.113
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
183 |
0.112
|
Human |
|
|
granulocyte chemotaxis
|
GO:0071621 |
37 |
0.110
|
|
|
|
positive regulation of protein transport
|
GO:0051222 |
135 |
0.110
|
|
|
|
regulation of podosome assembly
|
GO:0071801 |
5 |
0.108
|
|
|
|
response to molecule of bacterial origin
|
GO:0002237 |
82 |
0.108
|
|
|
|
single organism cell adhesion
|
GO:0098602 |
179 |
0.108
|
Human Fly |
|
|
ribonucleoside triphosphate catabolic process
|
GO:0009203 |
391 |
0.108
|
|
|
|
calcium ion homeostasis
|
GO:0055074 |
122 |
0.108
|
|
|
|
female gamete generation
|
GO:0007292 |
2 |
0.107
|
Fly |
|
|
positive regulation of mononuclear cell proliferation
|
GO:0032946 |
47 |
0.107
|
|
|
|
positive regulation of organelle organization
|
GO:0010638 |
195 |
0.107
|
|
|
|
negative regulation of cellular amino acid metabolic process
|
GO:0045763 |
2 |
0.106
|
|
|
|
activation of immune response
|
GO:0002253 |
114 |
0.106
|
Human |
|
|
inflammatory response
|
GO:0006954 |
79 |
0.104
|
|
|
|
determination of adult lifespan
|
GO:0008340 |
2 |
0.104
|
|
|
|
digestive tract development
|
GO:0048565 |
75 |
0.104
|
|
|
|
mast cell activation involved in immune response
|
GO:0002279 |
4 |
0.103
|
|
|
|
regulation of cell differentiation
|
GO:0045595 |
393 |
0.102
|
Human |
|
|
regulation of cellular component size
|
GO:0032535 |
82 |
0.102
|
Fly |
|
|
divalent inorganic cation transport
|
GO:0072511 |
158 |
0.101
|
|
|
|
positive regulation of purine nucleotide catabolic process
|
GO:0033123 |
185 |
0.100
|
|
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
267 |
0.100
|
Human |
|
|
regulation of peptide transport
|
GO:0090087 |
62 |
0.098
|
Human |
|
|
negative regulation of endopeptidase activity
|
GO:0010951 |
84 |
0.097
|
Human |
|
|
cell cell signaling
|
GO:0007267 |
155 |
0.097
|
Human Fly |
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.097
|
Human |
|
|
regulation of peptide secretion
|
GO:0002791 |
42 |
0.096
|
Human |
|
|
myeloid leukocyte differentiation
|
GO:0002573 |
60 |
0.096
|
|
|
|
protein autophosphorylation
|
GO:0046777 |
123 |
0.095
|
|
|
|
epidermal growth factor activated receptor transactivation by g protein coupled receptor signaling pathway
|
GO:0035625 |
4 |
0.095
|
|
|
|
regulation of behavior
|
GO:0050795 |
82 |
0.094
|
|
|
|
regulation of response to interferon gamma
|
GO:0060330 |
7 |
0.094
|
Human |
|
|
negative regulation of protein complex assembly
|
GO:0031333 |
43 |
0.094
|
Human |
|
|
sensory perception of pain
|
GO:0019233 |
4 |
0.093
|
|
|
|
nucleoside phosphate catabolic process
|
GO:1901292 |
412 |
0.093
|
|
|
|
positive regulation of nervous system development
|
GO:0051962 |
54 |
0.092
|
Human |
|
|
regulation of immune effector process
|
GO:0002697 |
91 |
0.091
|
|
|
|
formation of primary germ layer
|
GO:0001704 |
42 |
0.091
|
|
|
|
regulation of protein maturation
|
GO:1903317 |
150 |
0.090
|
Human |
|
|
regulation of neurogenesis
|
GO:0050767 |
82 |
0.090
|
Human |
|
|
receptor transactivation
|
GO:0035624 |
4 |
0.090
|
|
|
|
divalent metal ion transport
|
GO:0070838 |
152 |
0.089
|
|
|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
181 |
0.089
|
|
|
|
associative learning
|
GO:0008306 |
1 |
0.089
|
Fly |
|
|
regulation of mitochondrial depolarization
|
GO:0051900 |
6 |
0.088
|
Human |
|
|
cell substrate adhesion
|
GO:0031589 |
132 |
0.088
|
|
|
|
response to interleukin 1
|
GO:0070555 |
47 |
0.088
|
Human |
|
|
cellular component morphogenesis
|
GO:0032989 |
314 |
0.088
|
|
|
|
transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0007178 |
125 |
0.087
|
Human |
|
|
membrane protein ectodomain proteolysis
|
GO:0006509 |
33 |
0.086
|
|
|
|
positive regulation of ras gtpase activity
|
GO:0032320 |
117 |
0.085
|
|
|
|
positive regulation of cellular component movement
|
GO:0051272 |
181 |
0.085
|
|
|
|
positive regulation of acute inflammatory response
|
GO:0002675 |
2 |
0.084
|
|
|
|
regulation of jak stat cascade
|
GO:0046425 |
44 |
0.084
|
|
|
|
erk1 and erk2 cascade
|
GO:0070371 |
104 |
0.083
|
|
|
|
positive regulation of actin filament polymerization
|
GO:0030838 |
38 |
0.083
|
|
|
|
syncytium formation by plasma membrane fusion
|
GO:0000768 |
2 |
0.083
|
|
|
|
regulation of ras protein signal transduction
|
GO:0046578 |
155 |
0.082
|
|
|
|
growth
|
GO:0040007 |
202 |
0.082
|
Fly |
|
|
regulation of growth
|
GO:0040008 |
165 |
0.082
|
Fly |
|
|
oocyte development
|
GO:0048599 |
1 |
0.082
|
|
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
411 |
0.081
|
|
|
|
cellular response to retinoic acid
|
GO:0071300 |
19 |
0.080
|
Human |
|
|
leukocyte chemotaxis
|
GO:0030595 |
76 |
0.079
|
|
|
|
regulation of myeloid leukocyte mediated immunity
|
GO:0002886 |
4 |
0.079
|
|
|
|
positive regulation of response to external stimulus
|
GO:0032103 |
88 |
0.079
|
|
|
|
negative regulation of alpha beta t cell activation
|
GO:0046636 |
3 |
0.078
|
|
|
|
regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043281 |
116 |
0.078
|
Human |
|
|
regulation of rho gtpase activity
|
GO:0032319 |
66 |
0.078
|
|
|
|
regulation of neuron differentiation
|
GO:0045664 |
70 |
0.077
|
Human |
|
|
regulation of leukocyte differentiation
|
GO:1902105 |
61 |
0.077
|
|
|
|
tyrosine phosphorylation of stat protein
|
GO:0007260 |
33 |
0.077
|
Human |
|
|
phosphatidylinositol mediated signaling
|
GO:0048015 |
55 |
0.076
|
Human |
|
|
regulation of cell cycle
|
GO:0051726 |
393 |
0.075
|
|
|
|
microtubule cytoskeleton organization
|
GO:0000226 |
176 |
0.074
|
|
|
|
negative regulation of kinase activity
|
GO:0033673 |
106 |
0.074
|
Human |
|
|
ribonucleotide catabolic process
|
GO:0009261 |
405 |
0.074
|
|
|
|
lymphocyte mediated immunity
|
GO:0002449 |
48 |
0.073
|
|
|
|
transforming growth factor beta receptor signaling pathway
|
GO:0007179 |
76 |
0.073
|
Human |
|
|
epithelial cell cell adhesion
|
GO:0090136 |
7 |
0.073
|
Fly |
|
|
regulation of exocytosis
|
GO:0017157 |
46 |
0.073
|
|
|
|
multicellular organismal aging
|
GO:0010259 |
3 |
0.073
|
|
|
|
positive regulation of neuron projection development
|
GO:0010976 |
34 |
0.073
|
Human |
|
|
positive regulation of behavior
|
GO:0048520 |
60 |
0.071
|
|
|
|
chemical homeostasis
|
GO:0048878 |
306 |
0.070
|
Human |
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
211 |
0.070
|
|
|
|
positive regulation of nucleoside metabolic process
|
GO:0045979 |
186 |
0.069
|
|
|
|
positive regulation of transferase activity
|
GO:0051347 |
227 |
0.069
|
Human Fly |
|
|
negative regulation of dendritic cell differentiation
|
GO:2001199 |
2 |
0.068
|
|
|
|
regulation of gtp catabolic process
|
GO:0033124 |
180 |
0.067
|
|
|
|
signal release
|
GO:0023061 |
70 |
0.067
|
Human |
|
|
regulation of cytoplasmic transport
|
GO:1903649 |
149 |
0.066
|
Human |
|
|
gtp catabolic process
|
GO:0006184 |
237 |
0.066
|
|
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
267 |
0.066
|
Human |
|
|
membrane protein proteolysis
|
GO:0033619 |
38 |
0.066
|
|
|
|
cell fate commitment involved in formation of primary germ layer
|
GO:0060795 |
6 |
0.066
|
|
|
|
leukocyte activation involved in immune response
|
GO:0002366 |
30 |
0.066
|
|
|
|
negative regulation of cellular component movement
|
GO:0051271 |
106 |
0.065
|
|
|
|
regulation of nucleocytoplasmic transport
|
GO:0046822 |
98 |
0.065
|
|
|
|
morphogenesis of an epithelium
|
GO:0002009 |
60 |
0.065
|
Fly |
|
|
nucleoside catabolic process
|
GO:0009164 |
408 |
0.065
|
|
|
|
positive regulation of chemotaxis
|
GO:0050921 |
57 |
0.064
|
|
|
|
regulation of cell shape
|
GO:0008360 |
48 |
0.064
|
|
|
|
regulation of neuron projection development
|
GO:0010975 |
57 |
0.064
|
Human |
|
|
nucleocytoplasmic transport
|
GO:0006913 |
176 |
0.064
|
|
|
|
ras protein signal transduction
|
GO:0007265 |
73 |
0.064
|
|
|
|
negative regulation of intrinsic apoptotic signaling pathway
|
GO:2001243 |
40 |
0.062
|
Human |
|
|
positive regulation of purine nucleotide metabolic process
|
GO:1900544 |
227 |
0.061
|
|
|
|
inositol lipid mediated signaling
|
GO:0048017 |
55 |
0.061
|
Human |
|
|
t cell differentiation
|
GO:0030217 |
29 |
0.061
|
Human |
|
|
regulation of actin cytoskeleton reorganization
|
GO:2000249 |
12 |
0.060
|
|
|
|
neuromuscular junction development
|
GO:0007528 |
3 |
0.060
|
Fly |
|
|
blood coagulation
|
GO:0007596 |
76 |
0.059
|
|
|
|
positive regulation of immune effector process
|
GO:0002699 |
40 |
0.059
|
|
|
|
wound healing
|
GO:0042060 |
115 |
0.059
|
|
|
|
regulation of epithelial cell migration
|
GO:0010632 |
93 |
0.058
|
Human |
|
|
neuron differentiation
|
GO:0030182 |
138 |
0.058
|
Human Fly |
|
|
negative regulation of nervous system development
|
GO:0051961 |
28 |
0.058
|
Fly |
|
|
metal ion transport
|
GO:0030001 |
272 |
0.058
|
|
|
|
response to lipopolysaccharide
|
GO:0032496 |
70 |
0.057
|
|
|
|
positive regulation of leukocyte proliferation
|
GO:0070665 |
48 |
0.056
|
|
|
|
response to organonitrogen compound
|
GO:0010243 |
156 |
0.056
|
|
|
|
protein secretion
|
GO:0009306 |
98 |
0.056
|
|
|
|
positive regulation of lymphocyte differentiation
|
GO:0045621 |
13 |
0.055
|
|
|
|
positive regulation of intracellular protein transport
|
GO:0090316 |
76 |
0.055
|
|
|
|
cellular protein complex assembly
|
GO:0043623 |
188 |
0.055
|
|
|
|
positive regulation of leukocyte differentiation
|
GO:1902107 |
37 |
0.054
|
|
|
|
regulation of gamma delta t cell activation involved in immune response
|
GO:2001191 |
1 |
0.054
|
|
|
|
nucleoside triphosphate catabolic process
|
GO:0009143 |
394 |
0.054
|
|
|
|
gland morphogenesis
|
GO:0022612 |
8 |
0.053
|
Fly |
|
|
rac protein signal transduction
|
GO:0016601 |
12 |
0.053
|
|
|
|
negative regulation of immune response
|
GO:0050777 |
40 |
0.053
|
|
|
|
tube morphogenesis
|
GO:0035239 |
95 |
0.053
|
|
|
|
regulation of actin filament bundle assembly
|
GO:0032231 |
36 |
0.053
|
|
|
|
negative regulation of protein kinase activity
|
GO:0006469 |
98 |
0.053
|
Human |
|
|
regulation of purine nucleotide metabolic process
|
GO:1900542 |
264 |
0.053
|
|
|
|
phagocytosis
|
GO:0006909 |
42 |
0.052
|
|
|
|
positive regulation of actin filament bundle assembly
|
GO:0032233 |
25 |
0.052
|
|
|
|
regulation of dendritic cell apoptotic process
|
GO:2000668 |
4 |
0.051
|
|
|
|
cell cell junction organization
|
GO:0045216 |
69 |
0.051
|
Fly |
|
|
positive regulation of stress activated mapk cascade
|
GO:0032874 |
60 |
0.051
|
|
|
|
positive regulation of protein secretion
|
GO:0050714 |
60 |
0.051
|
|
|
|
regulation of mapk cascade
|
GO:0043408 |
262 |
0.051
|
|
|
|
negative regulation of phosphorylation
|
GO:0042326 |
174 |
0.050
|
Human |
|
|
lipoxygenase pathway
|
GO:0019372 |
4 |
0.050
|
|
|
|
negative regulation of cytokine production
|
GO:0001818 |
82 |
0.050
|
|
|
|
renal system development
|
GO:0072001 |
63 |
0.050
|
|
|
|
cell cell junction assembly
|
GO:0007043 |
25 |
0.050
|
Fly |
|
|
cellular response to abiotic stimulus
|
GO:0071214 |
117 |
0.050
|
|
|
|
negative regulation of protein modification process
|
GO:0031400 |
200 |
0.049
|
Human |
|
|
mitotic cell cycle process
|
GO:1903047 |
286 |
0.049
|
|
|
|
regulation of receptor mediated endocytosis
|
GO:0048259 |
32 |
0.049
|
Human |
|
|
anoikis
|
GO:0043276 |
22 |
0.049
|
Human |
