Homo sapiens

14 known processes

HEXB

hexosaminidase B (beta polypeptide)

(Aliases: ENC-1AS)

HEXB biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
carbohydrate metabolic process GO:0005975 207 0.562
Mouse
cellular response to thyroid hormone stimulus GO:0097067 9 0.414
single organism carbohydrate metabolic process GO:0044723 193 0.293
Mouse
lipid catabolic process GO:0016042 84 0.167
Mouse
response to thyroid hormone GO:0097066 9 0.159
determination of adult lifespan GO:0008340 2 0.151
cellular response to endogenous stimulus GO:0071495 336 0.122
regulation of peptidase activity GO:0052547 180 0.106
positive regulation of transport GO:0051050 336 0.102
sulfur compound metabolic process GO:0006790 101 0.095
immune response GO:0006955 307 0.095
cellular ion homeostasis GO:0006873 168 0.092
Mouse
post embryonic development GO:0009791 2 0.084
lipid metabolic process GO:0006629 381 0.075
Mouse
positive regulation of exocytosis GO:0045921 35 0.063
monosaccharide metabolic process GO:0005996 74 0.061
vesicle mediated transport GO:0016192 371 0.060
regulation of secretion GO:0051046 194 0.059
protein catabolic process GO:0030163 325 0.058
innate immune response GO:0045087 178 0.058
cellular macromolecule catabolic process GO:0044265 380 0.056
signal transduction by phosphorylation GO:0023014 297 0.056
ion transmembrane transport GO:0034220 338 0.056
regulation of secretion by cell GO:1903530 177 0.054
regulation of natural killer cell mediated cytotoxicity GO:0042269 16 0.054
secretion GO:0046903 254 0.053
basement membrane organization GO:0071711 3 0.051
blood vessel morphogenesis GO:0048514 162 0.050
Zebrafish
vacuole organization GO:0007033 44 0.050
Mouse
cellular lipid catabolic process GO:0044242 65 0.048
Mouse
endosomal transport GO:0016197 129 0.048
cellular homeostasis GO:0019725 196 0.047
Mouse
collagen catabolic process GO:0030574 10 0.044
cellular amide metabolic process GO:0043603 69 0.044
response to bacterium GO:0009617 144 0.042
epithelium development GO:0060429 227 0.041
positive regulation of secretion by cell GO:1903532 108 0.040
regulation of phospholipase a2 activity GO:0032429 4 0.040
regulation of cellular component movement GO:0051270 334 0.040
cellular response to hormone stimulus GO:0032870 125 0.039
positive regulation of leukocyte degranulation GO:0043302 3 0.039
response to hormone GO:0009725 175 0.039
negative regulation of serine type peptidase activity GO:1902572 2 0.039
system process GO:0003008 349 0.038
Mouse
regulation of vesicle mediated transport GO:0060627 130 0.038
protein processing GO:0016485 226 0.037
locomotory behavior GO:0007626 1 0.037
Mouse
positive regulation of secretion GO:0051047 116 0.037
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.037
transmembrane transport GO:0055085 399 0.036
protein maturation GO:0051604 233 0.036
regulation of cell motility GO:2000145 299 0.035
lysosome organization GO:0007040 24 0.035
Mouse
multicellular organismal aging GO:0010259 3 0.035
epithelial cell proliferation GO:0050673 128 0.034
posttranscriptional regulation of gene expression GO:0010608 213 0.034
regulation of response to external stimulus GO:0032101 222 0.034
cellular chemical homeostasis GO:0055082 180 0.033
Mouse
negative regulation of programmed cell death GO:0043069 321 0.033
angiogenesis GO:0001525 147 0.033
Zebrafish
chemical homeostasis GO:0048878 306 0.033
Mouse
cation homeostasis GO:0055080 189 0.032
Mouse
proteoglycan metabolic process GO:0006029 29 0.032
cellular response to growth factor stimulus GO:0071363 197 0.032
cellular amino acid metabolic process GO:0006520 116 0.032
oogenesis GO:0048477 2 0.031
Mouse
exocytosis GO:0006887 71 0.031
cellular response to glucocorticoid stimulus GO:0071385 4 0.031
apoptotic signaling pathway GO:0097190 268 0.030
response to oxidative stress GO:0006979 121 0.030
vasculature development GO:0001944 181 0.030
Zebrafish
regulation of vasculature development GO:1901342 97 0.029
regulation of protein localization GO:0032880 296 0.029
regulation of cytokine production GO:0001817 232 0.029
epithelial cell differentiation GO:0030855 141 0.029
regulation of proteolysis GO:0030162 293 0.028
multicellular organismal metabolic process GO:0044236 34 0.028
cytokine production GO:0001816 247 0.028
positive regulation of cellular component organization GO:0051130 376 0.028
negative regulation of fibroblast growth factor receptor signaling pathway GO:0040037 2 0.027
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.027
regulation of systemic arterial blood pressure by circulatory renin angiotensin GO:0001991 4 0.027
cellular ketone metabolic process GO:0042180 80 0.026
negative regulation of cellular protein metabolic process GO:0032269 353 0.026
hemopoiesis GO:0030097 180 0.026
regulation of innate immune response GO:0045088 97 0.026
cytoplasmic transport GO:0016482 379 0.025
secretion by cell GO:0032940 226 0.024
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.024
natural killer cell degranulation GO:0043320 2 0.024
neural tube patterning GO:0021532 2 0.024
tissue regeneration GO:0042246 3 0.023
glycoside metabolic process GO:0016137 13 0.023
behavior GO:0007610 112 0.023
Mouse
female gamete generation GO:0007292 2 0.023
Mouse
inorganic ion transmembrane transport GO:0098660 231 0.023
regulation of exocytosis GO:0017157 46 0.023
hexose metabolic process GO:0019318 55 0.023
wnt signaling pathway GO:0016055 156 0.023
positive regulation of cell death GO:0010942 263 0.023
positive regulation of natural killer cell activation GO:0032816 8 0.023
circulatory system development GO:0072359 262 0.022
Zebrafish
regulation of immune response GO:0050776 201 0.022
peptide metabolic process GO:0006518 51 0.022
leukocyte activation involved in immune response GO:0002366 30 0.022
immune effector process GO:0002252 159 0.022
regulation of microtubule based process GO:0032886 74 0.021
cellular component morphogenesis GO:0032989 314 0.021
Mouse
response to growth factor GO:0070848 205 0.021
lytic vacuole organization GO:0080171 24 0.021
Mouse
autophagy GO:0006914 88 0.021
regulation of ion transport GO:0043269 189 0.021
negative regulation of peptidase activity GO:0010466 91 0.021
cellular cation homeostasis GO:0030003 163 0.021
Mouse
ganglioside catabolic process GO:0006689 3 0.021
Mouse
regulation of cellular response to stress GO:0080135 244 0.021
blood circulation GO:0008015 113 0.021
myeloid cell differentiation GO:0030099 117 0.021
establishment of tissue polarity GO:0007164 3 0.021
negative regulation of proteolysis GO:0045861 132 0.021
negative regulation of cell proliferation GO:0008285 228 0.020
regulation of protein maturation GO:1903317 150 0.020
response to abiotic stimulus GO:0009628 336 0.020
cellular protein catabolic process GO:0044257 261 0.020
regulation of angiogenesis GO:0045765 92 0.020
defense response GO:0006952 315 0.020
regulation of cellular amino acid metabolic process GO:0006521 6 0.020
negative regulation of cellular response to growth factor stimulus GO:0090288 41 0.020
diterpenoid metabolic process GO:0016101 20 0.020
growth GO:0040007 202 0.020
regulation of locomotion GO:0040012 329 0.020
granzyme mediated apoptotic signaling pathway GO:0008626 4 0.020
single organism membrane organization GO:0044802 268 0.020
liposaccharide metabolic process GO:1903509 27 0.020
Mouse
negative regulation of catalytic activity GO:0043086 335 0.020
regulation of immune effector process GO:0002697 91 0.019
negative regulation of protein processing GO:0010955 142 0.019
regulation of intracellular transport GO:0032386 195 0.019
adult locomotory behavior GO:0008344 1 0.019
regulation of protein stability GO:0031647 87 0.019
enzyme linked receptor protein signaling pathway GO:0007167 303 0.019
regulation of cell migration GO:0030334 289 0.019
negative regulation of serine type endopeptidase activity GO:1900004 2 0.019
negative regulation of cell motility GO:2000146 104 0.019
negative regulation of multicellular organismal process GO:0051241 317 0.019
protein localization to organelle GO:0033365 280 0.019
cell growth GO:0016049 160 0.019
positive regulation of apoptotic process GO:0043065 246 0.019
lysosomal transport GO:0007041 33 0.019
lipid biosynthetic process GO:0008610 177 0.018
Mouse
regeneration GO:0031099 4 0.018
negative regulation of cell death GO:0060548 345 0.018
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 0.018
cellular response to external stimulus GO:0071496 111 0.018
regulation of protein secretion GO:0050708 86 0.018
membrane organization GO:0061024 292 0.018
ion homeostasis GO:0050801 230 0.018
Mouse
negative regulation of locomotion GO:0040013 118 0.018
regulation of blood pressure GO:0008217 30 0.017
cholesterol homeostasis GO:0042632 28 0.017
osteoclast development GO:0036035 2 0.017
protein homooligomerization GO:0051260 100 0.017
cation transmembrane transport GO:0098655 238 0.017
intracellular protein transport GO:0006886 270 0.017
syncytium formation by plasma membrane fusion GO:0000768 2 0.017
regulation of mapk cascade GO:0043408 262 0.017
hormone metabolic process GO:0042445 61 0.017
positive regulation of programmed cell death GO:0043068 249 0.017
membrane lipid metabolic process GO:0006643 53 0.017
Mouse
regulation of epithelial cell proliferation GO:0050678 113 0.017
regulation of endopeptidase activity GO:0052548 170 0.017
sphingolipid metabolic process GO:0006665 38 0.017
Mouse
response to cytokine GO:0034097 232 0.017
regulation of establishment of protein localization GO:0070201 242 0.017
positive regulation of lymphocyte activation GO:0051251 73 0.016
regulation of ion transmembrane transport GO:0034765 132 0.016
positive regulation of defense response GO:0031349 87 0.016
inorganic cation transmembrane transport GO:0098662 194 0.016
ribonucleotide catabolic process GO:0009261 405 0.016
negative regulation of blood pressure GO:0045776 3 0.016
positive regulation of calcium ion transport GO:0051928 51 0.016
cellular metal ion homeostasis GO:0006875 146 0.016
Mouse
vasodilation GO:0042311 4 0.016
leukocyte activation GO:0045321 164 0.016
negative regulation of apoptotic process GO:0043066 316 0.016
anatomical structure formation involved in morphogenesis GO:0048646 284 0.016
Zebrafish
regulation of rubidium ion transport GO:2000680 3 0.016
myeloid leukocyte differentiation GO:0002573 60 0.016
cytokinesis completion of separation GO:0007109 3 0.016
glycoprotein metabolic process GO:0009100 110 0.016
blood vessel development GO:0001568 172 0.016
Zebrafish
cell activation GO:0001775 213 0.015
positive regulation of cell motility GO:2000147 177 0.015
response to other organism GO:0051707 261 0.015
multicellular organismal macromolecule metabolic process GO:0044259 29 0.015
regulation of membrane potential GO:0042391 95 0.015
Mouse
embryo development GO:0009790 123 0.015
ganglioside metabolic process GO:0001573 7 0.015
Mouse
eye pigmentation GO:0048069 1 0.015
regulation of cellular response to growth factor stimulus GO:0090287 76 0.015
endomembrane system organization GO:0010256 196 0.015
regulation of protein processing GO:0070613 150 0.015
amine metabolic process GO:0009308 44 0.015
single organism carbohydrate catabolic process GO:0044724 33 0.015
Mouse
single organism reproductive process GO:0044702 98 0.015
Mouse
regulation of hormone levels GO:0010817 125 0.015
regulated secretory pathway GO:0045055 20 0.015
morphogenesis of a polarized epithelium GO:0001738 3 0.015
epithelium migration GO:0090132 119 0.015
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.015
immune system development GO:0002520 195 0.015
positive regulation of wnt signaling pathway GO:0030177 54 0.015
regulation of cellular amine metabolic process GO:0033238 11 0.015
positive regulation of cellular catabolic process GO:0031331 284 0.015
negative regulation of cellular component movement GO:0051271 106 0.015
positive regulation of phosphorylation GO:0042327 394 0.015
endocytosis GO:0006897 159 0.015
nervous system development GO:0007399 293 0.014
Mouse
regulation of wnt signaling pathway GO:0030111 123 0.014
cation transport GO:0006812 331 0.014
regulation of receptor mediated endocytosis GO:0048259 32 0.014
carbohydrate catabolic process GO:0016052 36 0.014
Mouse
positive regulation of cell activation GO:0050867 81 0.014
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.014
negative regulation of cell growth GO:0030308 83 0.014
prostate gland development GO:0030850 3 0.014
peripheral nervous system development GO:0007422 2 0.014
negative regulation of cell migration GO:0030336 102 0.014
negative regulation of transport GO:0051051 176 0.014
defense response to bacterium GO:0042742 63 0.014
protein stabilization GO:0050821 64 0.014
establishment of planar polarity GO:0001736 3 0.014
establishment of protein localization to organelle GO:0072594 172 0.014
microtubule based process GO:0007017 210 0.014
regulation of angiotensin metabolic process GO:0060177 3 0.014
positive regulation of immune response GO:0050778 159 0.014
cellular response to oxidative stress GO:0034599 85 0.014
cell type specific apoptotic process GO:0097285 125 0.014
maintenance of location GO:0051235 112 0.014
Mouse
sequestering of metal ion GO:0051238 24 0.014
cellular hormone metabolic process GO:0034754 41 0.014
multicellular organismal catabolic process GO:0044243 12 0.014
regulation of interleukin 8 production GO:0032677 49 0.014
cell killing GO:0001906 34 0.014
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.014
transforming growth factor beta1 production GO:0032905 3 0.013
negative regulation of hydrolase activity GO:0051346 182 0.013
response to inorganic substance GO:0010035 127 0.013
monovalent inorganic cation transport GO:0015672 128 0.013
neurological system process GO:0050877 163 0.013
Mouse
cholesterol efflux GO:0033344 28 0.013
positive regulation of immune system process GO:0002684 283 0.013
regulation of cytokine secretion GO:0050707 57 0.013
monocarboxylic acid metabolic process GO:0032787 185 0.013
regulation of cellular ketone metabolic process GO:0010565 50 0.013
positive regulation of natural killer cell mediated cytotoxicity GO:0045954 11 0.013
response to axon injury GO:0048678 1 0.013
cholesterol transport GO:0030301 39 0.013
positive regulation of ion transmembrane transporter activity GO:0032414 29 0.013
interleukin 8 production GO:0032637 51 0.013
regulation of autophagy GO:0010506 52 0.013
oxidation reduction process GO:0055114 396 0.013
positive regulation of hydrolase activity GO:0051345 331 0.013
positive regulation of synaptic transmission GO:0050806 4 0.013
mapk cascade GO:0000165 288 0.013
cellular response to hydrogen peroxide GO:0070301 37 0.013
regulation of serine type peptidase activity GO:1902571 2 0.013
reactive oxygen species biosynthetic process GO:1903409 4 0.013
golgi vesicle transport GO:0048193 80 0.013
small molecule biosynthetic process GO:0044283 157 0.012
aging GO:0007568 66 0.012
positive regulation of organelle organization GO:0010638 195 0.012
heparan sulfate proteoglycan metabolic process GO:0030201 12 0.012
negative regulation of growth GO:0045926 97 0.012
positive regulation of cell migration GO:0030335 172 0.012
reactive nitrogen species metabolic process GO:2001057 3 0.012
extracellular matrix disassembly GO:0022617 16 0.012
dephosphorylation GO:0016311 209 0.012
circulatory system process GO:0003013 113 0.012
cell division GO:0051301 168 0.012
organic hydroxy compound metabolic process GO:1901615 147 0.012
lipid localization GO:0010876 106 0.012
Mouse
leukocyte degranulation GO:0043299 11 0.012
regulation of protein transport GO:0051223 213 0.012
negative regulation of cell cycle GO:0045786 193 0.012
positive regulation of ion transmembrane transport GO:0034767 40 0.012
glycoprotein biosynthetic process GO:0009101 91 0.012
leukocyte mediated immunity GO:0002443 59 0.012
neuromuscular process GO:0050905 15 0.012
Mouse
lymphocyte activation GO:0046649 133 0.012
response to oxygen containing compound GO:1901700 369 0.012
cytoskeleton dependent intracellular transport GO:0030705 21 0.012
blastoderm segmentation GO:0007350 2 0.012
small gtpase mediated signal transduction GO:0007264 78 0.012
keratinocyte differentiation GO:0030216 36 0.012
long term memory GO:0007616 2 0.012
oligosaccharide metabolic process GO:0009311 13 0.012
Mouse
regulation of transferase activity GO:0051338 355 0.012
organelle assembly GO:0070925 176 0.012
glycosyl compound catabolic process GO:1901658 413 0.012
reproductive process GO:0022414 106 0.012
Mouse
basement membrane disassembly GO:0034769 2 0.012
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 43 0.012
natural killer cell activation GO:0030101 12 0.011
pinocytosis GO:0006907 8 0.011
cellular lipid metabolic process GO:0044255 303 0.011
Mouse
protein oligomerization GO:0051259 173 0.011
cell morphogenesis GO:0000902 296 0.011
Mouse
response to biotic stimulus GO:0009607 276 0.011
negative regulation of vasculature development GO:1901343 43 0.011
regulation of growth GO:0040008 165 0.011
positive regulation of proteolysis GO:0045862 142 0.011
positive regulation of cellular amine metabolic process GO:0033240 7 0.011
negative regulation of protein maturation GO:1903318 142 0.011
spermatid differentiation GO:0048515 4 0.011
negative regulation of endopeptidase activity GO:0010951 84 0.011
regulation of defense response GO:0031347 154 0.011
response to wounding GO:0009611 168 0.011
retinoid metabolic process GO:0001523 18 0.011
regulation of purine nucleotide metabolic process GO:1900542 264 0.011
regulation of serine type endopeptidase activity GO:1900003 2 0.011
steroid metabolic process GO:0008202 94 0.011
peptide catabolic process GO:0043171 10 0.011
regulation of cell growth GO:0001558 135 0.011
proteasomal protein catabolic process GO:0010498 176 0.011
isoprenoid metabolic process GO:0006720 39 0.011
memory GO:0007613 3 0.011
cofactor metabolic process GO:0051186 87 0.011
positive regulation of vesicle fusion GO:0031340 4 0.011
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.011
cell cycle phase transition GO:0044770 173 0.011
organic hydroxy compound transport GO:0015850 63 0.011
cellular amine metabolic process GO:0044106 41 0.011
generation of neurons GO:0048699 152 0.011
regulation of transmembrane transport GO:0034762 139 0.011
response to external biotic stimulus GO:0043207 261 0.011
negative regulation of intracellular signal transduction GO:1902532 183 0.011
negative regulation of protein modification process GO:0031400 200 0.011
regulation of metal ion transport GO:0010959 120 0.010
calcium ion homeostasis GO:0055074 122 0.010
Mouse
reactive oxygen species metabolic process GO:0072593 75 0.010
divalent metal ion transport GO:0070838 152 0.010
negative regulation of cellular component organization GO:0051129 235 0.010
regulation of protein catabolic process GO:0042176 155 0.010
carboxylic acid biosynthetic process GO:0046394 97 0.010
cellular response to organic cyclic compound GO:0071407 127 0.010
negative regulation of phospholipase activity GO:0010519 3 0.010
purine containing compound catabolic process GO:0072523 411 0.010
kinin cascade GO:0002254 1 0.010
rubidium ion transport GO:0035826 4 0.010
membrane raft organization GO:0031579 10 0.010
negative regulation of secretion by cell GO:1903531 52 0.010
negative regulation of protein metabolic process GO:0051248 391 0.010
segmentation GO:0035282 4 0.010
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090100 41 0.010
negative regulation of interleukin 8 secretion GO:2000483 2 0.010
mating GO:0007618 1 0.010
Mouse
response to tumor necrosis factor GO:0034612 76 0.010
regulation of cysteine type endopeptidase activity GO:2000116 127 0.010

HEXB disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.998
inherited metabolic disorder DOID:655 242 0.998
lysosomal storage disease DOID:3211 47 0.997
lipid storage disease DOID:9455 28 0.818
cerebral degeneration DOID:1443 16 0.690
central nervous system disease DOID:331 186 0.690
brain disease DOID:936 73 0.690
nervous system disease DOID:863 431 0.690
neuronal ceroid lipofuscinosis DOID:14503 11 0.076
mucopolysaccharidosis DOID:12798 11 0.052
musculoskeletal system disease DOID:17 223 0.040
connective tissue disease DOID:65 109 0.037
immune system disease DOID:2914 155 0.028
sphingolipidosis DOID:1927 14 0.020
epilepsy syndrome DOID:1826 41 0.018
variable age at onset electroclinical syndrome DOID:0050706 8 0.018
electroclinical syndrome DOID:0050701 32 0.018
progressive myoclonus epilepsy DOID:891 8 0.018
retinal disease DOID:5679 118 0.017
sensory system disease DOID:0050155 203 0.017
eye and adnexa disease DOID:1492 150 0.017
eye disease DOID:5614 149 0.017
gastrointestinal system disease DOID:77 36 0.015
cancer DOID:162 167 0.013
disease of cellular proliferation DOID:14566 174 0.013
bone disease DOID:0080001 88 0.013
leukodystrophy DOID:10579 8 0.010
retinal degeneration DOID:8466 89 0.010
gangliosidosis DOID:2368 4 0.001
gangliosidosis gm2 DOID:3321 3 0.001