Homo sapiens

199 known processes

HIF1A

hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

(Aliases: HIF1,MOP1,PASD8,HIF1-ALPHA,bHLHe78,HIF-1alpha)

HIF1A biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
gas homeostasis GO:0033483 4 1.000
response to nitric oxide GO:0071731 4 1.000
oxygen homeostasis GO:0032364 4 1.000
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 1.000
Rat
regulation of transcription from rna polymerase ii promoter in response to hypoxia GO:0061418 7 0.999
positive regulation of hormone biosynthetic process GO:0046886 4 0.999
protein hydroxylation GO:0018126 9 0.996
embryonic placenta development GO:0001892 1 0.996
Mouse
cell type specific apoptotic process GO:0097285 125 0.995
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.994
oogenesis GO:0048477 2 0.994
Fly
response to decreased oxygen levels GO:0036293 96 0.993
positive regulation of programmed cell death GO:0043068 249 0.992
Rat
blood vessel morphogenesis GO:0048514 162 0.990
Mouse
positive regulation of transcription from rna polymerase ii promoter in response to hypoxia GO:0061419 2 0.988
monocarboxylic acid metabolic process GO:0032787 185 0.986
Mouse
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 49 0.986
negative regulation of transcription from rna polymerase ii promoter in response to hypoxia GO:0061428 4 0.985
response to oxidative stress GO:0006979 121 0.984
regulation of reactive oxygen species metabolic process GO:2000377 41 0.984
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.983
4 hydroxyproline metabolic process GO:0019471 5 0.981
response to oxygen levels GO:0070482 100 0.978
response to hypoxia GO:0001666 96 0.978
activation of cysteine type endopeptidase activity GO:0097202 57 0.977
cellular response to dna damage stimulus GO:0006974 379 0.977
Fly
response to reactive oxygen species GO:0000302 61 0.976
Rat
cellular modified amino acid metabolic process GO:0006575 64 0.975
regulation of neuron apoptotic process GO:0043523 35 0.974
response to abiotic stimulus GO:0009628 336 0.972
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.971
apoptotic signaling pathway GO:0097190 268 0.970
positive regulation of apoptotic process GO:0043065 246 0.970
Rat
zymogen activation GO:0031638 70 0.967
response to oxygen containing compound GO:1901700 369 0.964
Zebrafish Mouse Rat Fly
positive regulation of protein catabolic process GO:0045732 75 0.958
female gamete generation GO:0007292 2 0.958
Fly
alpha amino acid metabolic process GO:1901605 72 0.956
cell development GO:0048468 328 0.955
Mouse Fly
cellular response to oxygen levels GO:0071453 55 0.954
regulation of dna templated transcription in response to stress GO:0043620 18 0.951
cellular response to hypoxia GO:0071456 51 0.951
protein catabolic process GO:0030163 325 0.946
angiogenesis GO:0001525 147 0.941
Mouse
response to nitrogen compound GO:1901698 184 0.931
Rat Fly
organ morphogenesis GO:0009887 147 0.930
Mouse
regulation of oxidative stress induced cell death GO:1903201 24 0.928
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.928
myeloid cell homeostasis GO:0002262 34 0.925
Mouse
cellular amino acid metabolic process GO:0006520 116 0.924
positive regulation of peptidase activity GO:0010952 88 0.924
regulation of cell cycle GO:0051726 393 0.919
Fly
positive regulation of catabolic process GO:0009896 310 0.910
Fly
chordate embryonic development GO:0043009 34 0.908
Mouse
cyclic nucleotide metabolic process GO:0009187 82 0.905
positive regulation of proteolysis GO:0045862 142 0.903
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.897
cardiovascular system development GO:0072358 262 0.893
Mouse
multicellular organismal aging GO:0010259 3 0.893
Worm
regulation of cellular ketone metabolic process by positive regulation of transcription from rna polymerase ii promoter GO:0072366 1 0.892
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 17 0.886
neuron apoptotic process GO:0051402 39 0.882
regulation of endopeptidase activity GO:0052548 170 0.864
peptidyl proline modification GO:0018208 15 0.858
positive regulation of cell death GO:0010942 263 0.856
Rat
determination of adult lifespan GO:0008340 2 0.855
Worm
camp metabolic process GO:0046058 61 0.842
regulation of peptidase activity GO:0052547 180 0.835
regulation of cysteine type endopeptidase activity GO:2000116 127 0.826
post embryonic development GO:0009791 2 0.817
erythrocyte homeostasis GO:0034101 31 0.807
Mouse
cellular response to decreased oxygen levels GO:0036294 51 0.806
circulatory system development GO:0072359 262 0.799
Mouse
regulation of erythrocyte differentiation GO:0045646 17 0.797
Mouse
negative regulation of oxidative stress induced cell death GO:1903202 17 0.786
protein processing GO:0016485 226 0.784
regulation of hormone levels GO:0010817 125 0.778
microtubule based movement GO:0007018 32 0.778
regulation of protein catabolic process GO:0042176 155 0.770
circadian behavior GO:0048512 2 0.751
thymocyte apoptotic process GO:0070242 2 0.736
Mouse
regulation of receptor biosynthetic process GO:0010869 15 0.736
cell death in response to oxidative stress GO:0036473 29 0.726
anatomical structure formation involved in morphogenesis GO:0048646 284 0.724
Mouse
blood vessel development GO:0001568 172 0.720
Mouse
response to inorganic substance GO:0010035 127 0.711
Rat
cellular response to starvation GO:0009267 58 0.710
Worm
positive regulation of endopeptidase activity GO:0010950 84 0.703
axon cargo transport GO:0008088 2 0.702
neuron death GO:0070997 65 0.698
intrinsic apoptotic signaling pathway GO:0097193 127 0.697
chemical homeostasis GO:0048878 306 0.694
response to organonitrogen compound GO:0010243 156 0.689
Rat Fly
regulation of proteolysis GO:0030162 293 0.686
positive regulation of hydrolase activity GO:0051345 331 0.680
regulation of vasculature development GO:1901342 97 0.667
glycoprotein biosynthetic process GO:0009101 91 0.650
immune system development GO:0002520 195 0.637
Mouse
negative regulation of apoptotic signaling pathway GO:2001234 97 0.635
homeostasis of number of cells GO:0048872 40 0.628
Mouse
wnt signaling pathway GO:0016055 156 0.627
protein maturation GO:0051604 233 0.619
embryo development GO:0009790 123 0.606
Mouse
regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902175 16 0.600
behavior GO:0007610 112 0.584
Mouse
peptidyl proline hydroxylation to 4 hydroxy l proline GO:0018401 4 0.579
cellular response to oxidative stress GO:0034599 85 0.573
regulation of transcription from rna polymerase ii promoter in response to oxidative stress GO:0043619 5 0.557
negative regulation of cell death GO:0060548 345 0.542
embryo development ending in birth or egg hatching GO:0009792 34 0.533
Mouse
neuron development GO:0048666 113 0.527
neuron projection development GO:0031175 106 0.525
cell morphogenesis GO:0000902 296 0.519
Mouse
regulation of striated muscle tissue development GO:0016202 26 0.519
regulation of angiogenesis GO:0045765 92 0.517
epithelium development GO:0060429 227 0.516
Mouse
negative regulation of catalytic activity GO:0043086 335 0.514
histone acetylation GO:0016573 93 0.513
regulation of camp metabolic process GO:0030814 52 0.509
myeloid cell differentiation GO:0030099 117 0.502
Mouse
skin development GO:0043588 76 0.502
cell projection organization GO:0030030 252 0.491
regulation of apoptotic signaling pathway GO:2001233 175 0.490
regulation of cell differentiation GO:0045595 393 0.471
Mouse
camp catabolic process GO:0006198 8 0.467
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902176 10 0.466
regulation of autophagy GO:0010506 52 0.461
Fly
neuron death in response to oxidative stress GO:0036475 9 0.460
cellular response to endogenous stimulus GO:0071495 336 0.459
Rat Fly
regulation of cellular response to oxidative stress GO:1900407 26 0.448
positive regulation of cell differentiation GO:0045597 211 0.444
Mouse
regulation of system process GO:0044057 101 0.443
Rat
macromolecule glycosylation GO:0043413 63 0.438
protein acetylation GO:0006473 116 0.436
organ formation GO:0048645 3 0.433
internal peptidyl lysine acetylation GO:0018393 97 0.432
nervous system development GO:0007399 293 0.426
Mouse
glycoprotein metabolic process GO:0009100 110 0.424
Mouse
cardiac chamber morphogenesis GO:0003206 26 0.422
Mouse
hemopoiesis GO:0030097 180 0.421
Mouse
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 10 0.409
cellular response to peptide GO:1901653 59 0.409
Rat Fly
carbohydrate metabolic process GO:0005975 207 0.407
Mouse
positive regulation of myoblast differentiation GO:0045663 6 0.406
ventricular septum morphogenesis GO:0060412 3 0.405
neurogenesis GO:0022008 169 0.402
Mouse
negative regulation of camp metabolic process GO:0030815 9 0.400
glycosylation GO:0070085 71 0.395
myoblast fusion GO:0007520 1 0.391
response to hormone GO:0009725 175 0.389
Rat Fly
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.384
regulation of striated muscle cell differentiation GO:0051153 25 0.382
neuron differentiation GO:0030182 138 0.374
Mouse
mitochondrion organization GO:0007005 156 0.367
carbohydrate derivative biosynthetic process GO:1901137 207 0.358
lens morphogenesis in camera type eye GO:0002089 2 0.357
cellular carbohydrate metabolic process GO:0044262 84 0.357
Mouse
peptidyl proline hydroxylation GO:0019511 6 0.349
response to hyperoxia GO:0055093 4 0.344
peptidyl tyrosine modification GO:0018212 170 0.340
cardiac muscle tissue development GO:0048738 39 0.340
reproductive structure development GO:0048608 55 0.335
Mouse
reproductive system development GO:0061458 56 0.334
Mouse
purine ribonucleotide biosynthetic process GO:0009152 79 0.331
regulation of muscle cell differentiation GO:0051147 31 0.331
response to activity GO:0014823 0 0.330
Mouse Rat
protein modification by small protein conjugation GO:0032446 342 0.329
cellular response to nutrient levels GO:0031669 69 0.323
Worm
positive regulation of dna templated transcription elongation GO:0032786 18 0.323
epidermis development GO:0008544 59 0.321
protein localization to organelle GO:0033365 280 0.317
embryonic organ development GO:0048568 36 0.312
Mouse
hormone metabolic process GO:0042445 61 0.310
positive regulation of transcription from rna polymerase ii promoter in response to stress GO:0036003 9 0.310
response to insulin GO:0032868 45 0.308
Rat Fly
myoblast differentiation GO:0045445 21 0.308
regulation of anatomical structure size GO:0090066 101 0.307
Rat
cellular response to external stimulus GO:0071496 111 0.307
Rat Worm
methylation dependent chromatin silencing GO:0006346 3 0.306
cell morphogenesis involved in differentiation GO:0000904 144 0.306
Mouse
signal transduction by phosphorylation GO:0023014 297 0.304
cellular homeostasis GO:0019725 196 0.303
Mouse Rat
response to peptide GO:1901652 65 0.303
Rat Fly
regulation of secretion by cell GO:1903530 177 0.301
Mouse
negative regulation of phosphate metabolic process GO:0045936 267 0.297
cyclic nucleotide catabolic process GO:0009214 9 0.291
bmp signaling pathway involved in heart development GO:0061312 3 0.289
negative regulation of t cell apoptotic process GO:0070233 4 0.286
Mouse
muscle structure development GO:0061061 98 0.281
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.280
somitogenesis GO:0001756 2 0.274
rhythmic behavior GO:0007622 2 0.273
regulation of myoblast differentiation GO:0045661 12 0.272
cellular amine metabolic process GO:0044106 41 0.271
circadian regulation of gene expression GO:0032922 8 0.268
carbon catabolite activation of transcription GO:0045991 3 0.263
receptor biosynthetic process GO:0032800 18 0.263
urogenital system development GO:0001655 65 0.259
memory GO:0007613 3 0.253
regulation of cell migration GO:0030334 289 0.253
Mouse Fly
aging GO:0007568 66 0.252
Worm
response to increased oxygen levels GO:0036296 4 0.248
rhythmic process GO:0048511 31 0.247
striated muscle tissue development GO:0014706 59 0.245
negative regulation of cell proliferation GO:0008285 228 0.244
cellular component morphogenesis GO:0032989 314 0.240
Mouse
positive regulation of developmental process GO:0051094 314 0.239
Mouse
cell morphogenesis involved in neuron differentiation GO:0048667 44 0.234
transmembrane transport GO:0055085 399 0.233
heart morphogenesis GO:0003007 48 0.233
Mouse
tube development GO:0035295 125 0.232
Mouse
internal protein amino acid acetylation GO:0006475 101 0.231
positive regulation of muscle cell differentiation GO:0051149 15 0.227
negative regulation of response to oxidative stress GO:1902883 18 0.227
cellular response to hormone stimulus GO:0032870 125 0.227
Rat Fly
camp biosynthetic process GO:0006171 47 0.226
regulation of canonical wnt signaling pathway GO:0060828 88 0.226
response to purine containing compound GO:0014074 40 0.225
Rat
regulation of heart contraction GO:0008016 50 0.224
positive regulation of transcription by galactose GO:0000411 1 0.223
metal ion transport GO:0030001 272 0.219
muscle tissue development GO:0060537 62 0.216
regulation of neuron death GO:1901214 56 0.215
regulation of cellular amine metabolic process GO:0033238 11 0.214
regulation of cellular component biogenesis GO:0044087 281 0.213
segmentation GO:0035282 4 0.212
response to nutrient levels GO:0031667 81 0.211
Worm
regulation of cellular response to stress GO:0080135 244 0.206
lung development GO:0030324 20 0.204
oxidation reduction process GO:0055114 396 0.196
circulatory system process GO:0003013 113 0.196
Rat
cellular response to cytokine stimulus GO:0071345 181 0.195
cellular response to organonitrogen compound GO:0071417 124 0.194
Rat Fly
regulation of viral process GO:0050792 103 0.189
hematopoietic or lymphoid organ development GO:0048534 186 0.189
Mouse
regulation of response to external stimulus GO:0032101 222 0.186
dendrite development GO:0016358 24 0.184
hormone biosynthetic process GO:0042446 22 0.183
muscle cell differentiation GO:0042692 63 0.182
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 40 0.180
cellular response to interleukin 1 GO:0071347 35 0.176
regulation of blood circulation GO:1903522 59 0.175
Rat
carbon catabolite activation of transcription from rna polymerase ii promoter GO:0000436 3 0.172
regulation of ossification GO:0030278 58 0.170
Mouse
cellular polysaccharide metabolic process GO:0044264 27 0.169
negative regulation of phosphorus metabolic process GO:0010563 267 0.166
regulation of muscle organ development GO:0048634 27 0.164
generation of neurons GO:0048699 152 0.163
Mouse
regulation of methylation dependent chromatin silencing GO:0090308 3 0.160
leukocyte apoptotic process GO:0071887 31 0.159
Mouse
muscle organ development GO:0007517 56 0.159
syncytium formation by plasma membrane fusion GO:0000768 2 0.159
response to biotic stimulus GO:0009607 276 0.158
Rat
regulation of cell development GO:0060284 161 0.157
Mouse
lipid transport GO:0006869 90 0.157
regulation of carbohydrate metabolic process GO:0006109 54 0.156
Mouse
regulation of cyclic nucleotide phosphodiesterase activity GO:0051342 4 0.155
single organism carbohydrate metabolic process GO:0044723 193 0.154
Mouse
positive regulation of transcription initiation from rna polymerase ii promoter GO:0060261 4 0.154
organonitrogen compound biosynthetic process GO:1901566 200 0.154
locomotory behavior GO:0007626 1 0.152
response to cytokine GO:0034097 232 0.149
multi organism cellular process GO:0044764 156 0.148
regulation of cytokine production GO:0001817 232 0.146
response to metal ion GO:0010038 84 0.144
Rat
cation homeostasis GO:0055080 189 0.144
Mouse
trophectodermal cell differentiation GO:0001829 3 0.142
epidermal cell differentiation GO:0009913 45 0.141
vasculature development GO:0001944 181 0.141
Mouse
response to ionizing radiation GO:0010212 65 0.140
Rat
neuron intrinsic apoptotic signaling pathway in response to oxidative stress GO:0036480 7 0.138
cellular response to insulin stimulus GO:0032869 41 0.138
Rat Fly
somatic muscle development GO:0007525 1 0.132
ossification GO:0001503 121 0.130
Mouse
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 37 0.129
regulation of response to oxidative stress GO:1902882 26 0.127
peptidyl lysine acetylation GO:0018394 101 0.125
ventricular septum development GO:0003281 5 0.124
system process GO:0003008 349 0.124
Mouse Rat
histone modification GO:0016570 251 0.124
protein dna complex assembly GO:0065004 64 0.124
pituitary gland development GO:0021983 2 0.123
regulation of transforming growth factor beta production GO:0071634 13 0.123
cytoplasmic transport GO:0016482 379 0.123
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.118
protein ubiquitination GO:0016567 314 0.117
cellular protein complex assembly GO:0043623 188 0.117
epithelial cell differentiation GO:0030855 141 0.116
Mouse
regulation of wnt signaling pathway GO:0030111 123 0.116
neurological system process GO:0050877 163 0.114
Mouse
negative regulation of cellular response to oxidative stress GO:1900408 18 0.113
chromatin modification GO:0016568 298 0.111
leukocyte differentiation GO:0002521 98 0.111
cellular response to peptide hormone stimulus GO:0071375 56 0.108
Rat Fly
regulation of oxidative stress induced neuron death GO:1903203 9 0.108
secretory granule organization GO:0033363 2 0.108
embryonic camera type eye morphogenesis GO:0048596 2 0.107
viral life cycle GO:0019058 132 0.107
osteoblast differentiation GO:0001649 92 0.103
regulation of dendrite development GO:0050773 18 0.102
digestive system development GO:0055123 75 0.102
Mouse
kidney development GO:0001822 53 0.102
developmental process involved in reproduction GO:0003006 66 0.101
Mouse Fly
covalent chromatin modification GO:0016569 254 0.100
maintenance of location GO:0051235 112 0.100
camera type eye development GO:0043010 25 0.099
Mouse
phospholipid catabolic process GO:0009395 12 0.097
regulation of homeostatic process GO:0032844 121 0.094
Mouse
heart development GO:0007507 95 0.094
Mouse
embryonic skeletal system development GO:0048706 13 0.094
protein import GO:0017038 130 0.093
negative regulation of peptidase activity GO:0010466 91 0.092
cellular ketone metabolic process GO:0042180 80 0.092
regulation of stress activated mapk cascade GO:0032872 84 0.091
regulation of transcription involved in g2 m transition of mitotic cell cycle GO:0000117 1 0.090
regulation of lymphocyte apoptotic process GO:0070228 15 0.089
Mouse
regulation of cellular component movement GO:0051270 334 0.087
Mouse Fly
dendrite morphogenesis GO:0048813 14 0.086
response to other organism GO:0051707 261 0.086
Rat
mapk cascade GO:0000165 288 0.086
peptidyl tyrosine phosphorylation GO:0018108 170 0.086
positive regulation vascular endothelial growth factor production GO:0010575 12 0.086
norepinephrine metabolic process GO:0042415 1 0.086
negative regulation of thymocyte apoptotic process GO:0070244 1 0.085
Mouse
regulation of protein localization GO:0032880 296 0.085
multi organism metabolic process GO:0044033 41 0.085
ameboidal type cell migration GO:0001667 135 0.083
Mouse
neuron projection morphogenesis GO:0048812 50 0.083
regulation of cell projection organization GO:0031344 107 0.083
protein targeting GO:0006605 187 0.083
glucan metabolic process GO:0044042 22 0.082
visual perception GO:0007601 27 0.082
negative regulation of cellular amine metabolic process GO:0033239 3 0.082
positive regulation of neuron differentiation GO:0045666 40 0.082
regulation of anatomical structure morphogenesis GO:0022603 286 0.081
regulation of cell cycle process GO:0010564 266 0.080
positive regulation of cellular component biogenesis GO:0044089 158 0.080
negative regulation of locomotion GO:0040013 118 0.079
cell projection morphogenesis GO:0048858 129 0.079
reproduction GO:0000003 63 0.078
Rat Fly
protein autophosphorylation GO:0046777 123 0.077
apoptotic mitochondrial changes GO:0008637 57 0.076
regulation of secretion GO:0051046 194 0.076
Mouse
blood vessel remodeling GO:0001974 2 0.075
intracellular protein transport GO:0006886 270 0.075
cellular protein catabolic process GO:0044257 261 0.075
cell part morphogenesis GO:0032990 137 0.075
regulation of fat cell differentiation GO:0045598 23 0.074
regulation of cell motility GO:2000145 299 0.074
Mouse Fly
regulation of cyclic nucleotide metabolic process GO:0030799 63 0.074
reactive oxygen species biosynthetic process GO:1903409 4 0.074
regulation of transcription by galactose GO:0000409 1 0.074
establishment of protein localization to organelle GO:0072594 172 0.073
actin cytoskeleton organization GO:0030036 207 0.073
reproductive process GO:0022414 106 0.072
Mouse Rat Fly
cellular senescence GO:0090398 34 0.071
protein localization to nucleus GO:0034504 136 0.071
carbohydrate biosynthetic process GO:0016051 42 0.071
chemical homeostasis within a tissue GO:0048875 3 0.070
posttranscriptional regulation of gene expression GO:0010608 213 0.070
cellular macromolecular complex assembly GO:0034622 324 0.070
negative regulation of growth GO:0045926 97 0.070
Mouse Fly
regulation of heart growth GO:0060420 4 0.070
chromatin organization GO:0006325 351 0.070
intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator GO:0042771 23 0.069
heart contraction GO:0060047 62 0.069
generation of precursor metabolites and energy GO:0006091 68 0.067
Mouse
plasma membrane organization GO:0007009 115 0.067
positive regulation of cell size GO:0045793 3 0.067
Rat
regulation of myeloid cell differentiation GO:0045637 81 0.067
Mouse
blood circulation GO:0008015 113 0.067
Rat
reactive oxygen species metabolic process GO:0072593 75 0.066
reactive nitrogen species metabolic process GO:2001057 3 0.065
response to drug GO:0042493 81 0.065
Rat
cardiac chamber development GO:0003205 30 0.065
Mouse
positive regulation of secretion by cell GO:1903532 108 0.064
Mouse
regulation of mitotic cell cycle GO:0007346 189 0.064
modulation by host of viral transcription GO:0043921 20 0.064
regulation of meiotic cell cycle GO:0051445 4 0.063
negative regulation of ossification GO:0030279 21 0.062
Mouse
transforming growth factor beta production GO:0071604 14 0.062
positive regulation of gluconeogenesis GO:0045722 1 0.062
placenta development GO:0001890 10 0.062
Mouse
vesicle organization GO:0016050 62 0.061
cellular response to oxygen containing compound GO:1901701 276 0.061
Mouse Rat Fly
negative regulation of intracellular signal transduction GO:1902532 183 0.061
regulation of ion transport GO:0043269 189 0.061
regulation of neuron differentiation GO:0045664 70 0.060
positive regulation of myeloid cell apoptotic process GO:0033034 2 0.060
lipid localization GO:0010876 106 0.060
regulation of metal ion transport GO:0010959 120 0.058
negative regulation of multicellular organismal process GO:0051241 317 0.058
Mouse Rat
regulation of transcription by chromatin organization GO:0034401 1 0.058
chondroitin sulfate proteoglycan biosynthetic process GO:0050650 10 0.057
positive regulation of glucose metabolic process GO:0010907 12 0.057
fibroblast proliferation GO:0048144 33 0.057
regulation of cardiac muscle tissue development GO:0055024 13 0.057
post embryonic organ development GO:0048569 1 0.057
negative regulation of binding GO:0051100 57 0.057
tube morphogenesis GO:0035239 95 0.057
Mouse
response to heat GO:0009408 21 0.057
Worm
regulation of cellular component size GO:0032535 82 0.056
Rat
single organism reproductive process GO:0044702 98 0.056
Mouse Rat Fly
autophagy GO:0006914 88 0.056
Fly
ectoderm development GO:0007398 3 0.056
myotube differentiation GO:0014902 22 0.056
positive regulation of cellular component organization GO:0051130 376 0.055
positive regulation of cell cycle GO:0045787 140 0.055
negative regulation of apoptotic process GO:0043066 316 0.055
blood vessel endothelial cell migration GO:0043534 42 0.055
positive regulation of feeding behavior GO:2000253 1 0.054
long term memory GO:0007616 2 0.054
kidney morphogenesis GO:0060993 19 0.054
proteasomal protein catabolic process GO:0010498 176 0.054
regulation of b cell activation GO:0050864 24 0.054
defense response GO:0006952 315 0.054
Mouse
negative regulation of reactive oxygen species biosynthetic process GO:1903427 1 0.054
multicellular organismal reproductive process GO:0048609 40 0.053
Rat Fly
negative regulation of cell differentiation GO:0045596 171 0.053
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.053
mating GO:0007618 1 0.052
g protein coupled receptor signaling pathway GO:0007186 207 0.052
trachea development GO:0060438 1 0.052
Fly
lymphocyte homeostasis GO:0002260 4 0.052
Mouse
carbon catabolite regulation of transcription from rna polymerase ii promoter GO:0000429 3 0.051
cellular response to nitrogen compound GO:1901699 144 0.051
Rat Fly
trabecula morphogenesis GO:0061383 2 0.050
cyclic purine nucleotide metabolic process GO:0052652 60 0.050
regulation of multi organism process GO:0043900 157 0.050
cellular macromolecule catabolic process GO:0044265 380 0.050
ion homeostasis GO:0050801 230 0.050
Mouse
peptidyl lysine modification GO:0018205 144 0.049
chondroitin sulfate proteoglycan metabolic process GO:0050654 10 0.049
cellular biogenic amine metabolic process GO:0006576 34 0.049
response to molecule of bacterial origin GO:0002237 82 0.049
Rat
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.048
rna polymerase ii transcriptional preinitiation complex assembly GO:0051123 4 0.048
response to tumor necrosis factor GO:0034612 76 0.048
chemotaxis GO:0006935 157 0.047
purine ribonucleoside metabolic process GO:0046128 437 0.047
regeneration GO:0031099 4 0.047
response to calcium ion GO:0051592 46 0.047
regulation of leukocyte apoptotic process GO:2000106 25 0.046
Mouse
negative regulation of hydrolase activity GO:0051346 182 0.046
blastocyst development GO:0001824 3 0.046
response to bacterium GO:0009617 144 0.046
Rat
negative regulation of endopeptidase activity GO:0010951 84 0.045
erythrocyte differentiation GO:0030218 28 0.045
Mouse
mononuclear cell proliferation GO:0032943 71 0.045
glycogen metabolic process GO:0005977 22 0.045
protein glycosylation GO:0006486 62 0.045
regulation of glucocorticoid receptor signaling pathway GO:2000322 2 0.045
organ induction GO:0001759 4 0.045
blastocyst formation GO:0001825 3 0.045
myeloid leukocyte differentiation GO:0002573 60 0.044
regulation of growth rate GO:0040009 1 0.044
positive regulation of skeletal muscle cell differentiation GO:2001016 1 0.044
positive regulation of defense response GO:0031349 87 0.044
response to lipid GO:0033993 206 0.044
Rat
protein acylation GO:0043543 138 0.044
response to xenobiotic stimulus GO:0009410 30 0.044
cellular response to extracellular stimulus GO:0031668 72 0.043
Worm
superoxide metabolic process GO:0006801 20 0.043
positive regulation of glucocorticoid receptor signaling pathway GO:2000324 1 0.043
modification dependent protein catabolic process GO:0019941 209 0.043
positive regulation of cell projection organization GO:0031346 64 0.042
anterior posterior axis specification embryo GO:0008595 2 0.042
digestive tract development GO:0048565 75 0.041
Mouse
transition metal ion homeostasis GO:0055076 31 0.041
Mouse
negative regulation of neuron apoptotic process GO:0043524 23 0.041
lung saccule development GO:0060430 2 0.041
b cell proliferation GO:0042100 22 0.041
stem cell maintenance GO:0019827 19 0.041
negative regulation of lymphocyte apoptotic process GO:0070229 8 0.040
Mouse
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.040
single organism behavior GO:0044708 28 0.040
Mouse
cellular response to hydrogen peroxide GO:0070301 37 0.040
Rat
regulation of glial cell differentiation GO:0045685 3 0.040
regulation of locomotion GO:0040012 329 0.040
Mouse Fly
response to organic cyclic compound GO:0014070 204 0.039
Rat
response to organophosphorus GO:0046683 41 0.039
heart induction GO:0003129 4 0.039
regulation of transforming growth factor beta2 production GO:0032909 6 0.039
striated muscle cell differentiation GO:0051146 43 0.039
regulation of tube size GO:0035150 18 0.039
Rat
mitochondrial transport GO:0006839 60 0.039
regulation of lipid transport by regulation of transcription from rna polymerase ii promoter GO:0072367 4 0.039
muscle cell development GO:0055001 29 0.038
regulation of hormone metabolic process GO:0032350 14 0.038

HIF1A disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 174 0.252
renal cell carcinoma DOID:4450 8 0.213
organ system cancer DOID:0050686 164 0.213
kidney cancer DOID:263 11 0.213
hereditary renal cell carcinoma DOID:4455 6 0.213
nonpapillary renal cell carcinoma DOID:0050387 6 0.213
renal carcinoma DOID:4451 8 0.213
urinary system cancer DOID:3996 15 0.213
cancer DOID:162 167 0.213