Homo sapiens

22 known processes

HIST1H2BC

histone cluster 1, H2bc

(Aliases: MGC104246,dJ221C16.3,H2B/g,H2B/a,H2B/l,H2B.1,H2BFL,H2B/h,H2B/k)

HIST1H2BC biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
dna replication dependent nucleosome assembly GO:0006335 32 1.000
dna replication independent nucleosome organization GO:0034724 27 1.000
nucleosome assembly GO:0006334 50 1.000
dna replication independent nucleosome assembly GO:0006336 27 1.000
chromatin assembly GO:0031497 61 1.000
chromatin assembly or disassembly GO:0006333 78 0.999
Yeast
dna replication dependent nucleosome organization GO:0034723 32 0.999
regulation of hematopoietic progenitor cell differentiation GO:1901532 24 0.997
nucleosome organization GO:0034728 66 0.987
mucosal immune response GO:0002385 21 0.981
postreplication repair GO:0006301 12 0.979
Yeast
defense response to gram positive bacterium GO:0050830 29 0.948
chromatin organization GO:0006325 351 0.912
Yeast
negative regulation of megakaryocyte differentiation GO:0045653 16 0.911
chromatin disassembly GO:0031498 13 0.861
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.861
Yeast
antibacterial humoral response GO:0019731 24 0.804
nucleosome disassembly GO:0006337 12 0.744
dna repair GO:0006281 198 0.732
Yeast
dna conformation change GO:0071103 113 0.730
dna packaging GO:0006323 77 0.716
negative regulation of hematopoietic progenitor cell differentiation GO:1901533 18 0.701
cellular response to dna damage stimulus GO:0006974 379 0.683
Yeast
protein complex disassembly GO:0043241 52 0.578
defense response to bacterium GO:0042742 63 0.563
defense response to other organism GO:0098542 129 0.555
response to biotic stimulus GO:0009607 276 0.535
immune response GO:0006955 307 0.482
response to other organism GO:0051707 261 0.434
response to uv GO:0009411 73 0.385
response to bacterium GO:0009617 144 0.378
hemopoiesis GO:0030097 180 0.372
negative regulation of myeloid cell differentiation GO:0045638 42 0.364
myeloid cell differentiation GO:0030099 117 0.338
defense response GO:0006952 315 0.329
cellular macromolecular complex assembly GO:0034622 324 0.327
protein dna complex subunit organization GO:0071824 80 0.316
cellular response to uv GO:0034644 32 0.314
megakaryocyte differentiation GO:0030219 25 0.312
organ or tissue specific immune response GO:0002251 22 0.311
hematopoietic progenitor cell differentiation GO:0002244 38 0.307
regulation of cell differentiation GO:0045595 393 0.264
response to external biotic stimulus GO:0043207 261 0.250
histone modification GO:0016570 251 0.240
innate immune response in mucosa GO:0002227 20 0.175
cell cycle checkpoint GO:0000075 117 0.175
negative regulation of immune system process GO:0002683 136 0.161
humoral immune response GO:0006959 49 0.157
methylation GO:0032259 106 0.153
cellular response to abiotic stimulus GO:0071214 117 0.150
gene silencing GO:0016458 49 0.140
uv damage excision repair GO:0070914 7 0.137
response to light stimulus GO:0009416 87 0.137
negative regulation of multicellular organismal process GO:0051241 317 0.132
innate immune response GO:0045087 178 0.125
negative regulation of developmental process GO:0051093 247 0.117
regulation of gene expression epigenetic GO:0040029 73 0.110
antimicrobial humoral response GO:0019730 26 0.105
chromatin modification GO:0016568 298 0.105
rna processing GO:0006396 255 0.104
mrna processing GO:0006397 133 0.102
response to radiation GO:0009314 151 0.091
regulation of myeloid cell differentiation GO:0045637 81 0.085
macromolecular complex disassembly GO:0032984 60 0.083
hematopoietic or lymphoid organ development GO:0048534 186 0.070
negative regulation of cell differentiation GO:0045596 171 0.065
mrna metabolic process GO:0016071 175 0.064
dna damage checkpoint GO:0000077 68 0.058
response to abiotic stimulus GO:0009628 336 0.057
anatomical structure formation involved in morphogenesis GO:0048646 284 0.056
immune system development GO:0002520 195 0.053
post embryonic development GO:0009791 2 0.052
cellular response to radiation GO:0071478 65 0.052
macromolecule methylation GO:0043414 97 0.050
protein dna complex disassembly GO:0032986 12 0.049
dna integrity checkpoint GO:0031570 71 0.049
cellular component disassembly GO:0022411 92 0.047
protein localization to organelle GO:0033365 280 0.047
cellular amino acid metabolic process GO:0006520 116 0.043
amine metabolic process GO:0009308 44 0.041
regulation of cellular amino acid metabolic process GO:0006521 6 0.036
cellular ketone metabolic process GO:0042180 80 0.035
regulation of megakaryocyte differentiation GO:0045652 22 0.035
cellular amine metabolic process GO:0044106 41 0.035
protein dna complex assembly GO:0065004 64 0.034
determination of adult lifespan GO:0008340 2 0.033
regulation of cellular ketone metabolic process GO:0010565 50 0.033
positive regulation of cellular component organization GO:0051130 376 0.032
regulation of cellular amine metabolic process GO:0033238 11 0.032
regulation of cell cycle GO:0051726 393 0.031
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.029
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.028
locomotory behavior GO:0007626 1 0.028
mitotic cell cycle GO:0000278 326 0.026
positive regulation of cellular amine metabolic process GO:0033240 7 0.026
negative regulation of cellular protein metabolic process GO:0032269 353 0.026
regulation of growth GO:0040008 165 0.026
multicellular organismal aging GO:0010259 3 0.024
organophosphate catabolic process GO:0046434 430 0.024
small gtpase mediated signal transduction GO:0007264 78 0.024
segmentation GO:0035282 4 0.023
nucleoside triphosphate metabolic process GO:0009141 422 0.023
positive regulation of cellular catabolic process GO:0031331 284 0.023
regulation of proteolysis GO:0030162 293 0.023
purine nucleoside catabolic process GO:0006152 398 0.022
nucleotide catabolic process GO:0009166 408 0.022
memory GO:0007613 3 0.022
ras protein signal transduction GO:0007265 73 0.022
purine ribonucleoside metabolic process GO:0046128 437 0.022
ribonucleotide catabolic process GO:0009261 405 0.022
female gamete generation GO:0007292 2 0.022
cellular lipid metabolic process GO:0044255 303 0.022
purine nucleoside triphosphate metabolic process GO:0009144 412 0.022
neuromuscular junction development GO:0007528 3 0.022
regeneration GO:0031099 4 0.021
positive regulation of organelle organization GO:0010638 195 0.021
oogenesis GO:0048477 2 0.021
purine containing compound catabolic process GO:0072523 411 0.021
ribonucleoside triphosphate metabolic process GO:0009199 412 0.021
positive regulation of hydrolase activity GO:0051345 331 0.021
negative regulation of phosphorus metabolic process GO:0010563 267 0.021
negative regulation of protein metabolic process GO:0051248 391 0.021
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.020
regulation of meiotic cell cycle GO:0051445 4 0.020
purine ribonucleoside catabolic process GO:0046130 398 0.020
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.020
negative regulation of cell cycle GO:0045786 193 0.020
positive regulation of transport GO:0051050 336 0.020
purine nucleotide catabolic process GO:0006195 405 0.020
lipid metabolic process GO:0006629 381 0.020
negative regulation of catalytic activity GO:0043086 335 0.020
ribonucleoside triphosphate catabolic process GO:0009203 391 0.020
posttranscriptional regulation of gene expression GO:0010608 213 0.020
purine ribonucleotide catabolic process GO:0009154 404 0.019
vesicle mediated transport GO:0016192 371 0.019
transmembrane transport GO:0055085 399 0.019
protein catabolic process GO:0030163 325 0.019
regulation of cell growth GO:0001558 135 0.019
cellular macromolecule catabolic process GO:0044265 380 0.019
covalent chromatin modification GO:0016569 254 0.019
single organism membrane organization GO:0044802 268 0.019
oocyte differentiation GO:0009994 2 0.019
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.019
positive regulation of growth GO:0045927 58 0.019
cytoplasmic transport GO:0016482 379 0.019
biological adhesion GO:0022610 331 0.019
morphogenesis of embryonic epithelium GO:0016331 4 0.019
regulation of transferase activity GO:0051338 355 0.018
rho protein signal transduction GO:0007266 26 0.018
nucleoside catabolic process GO:0009164 408 0.018
regulation of gene silencing GO:0060968 24 0.018
cell adhesion GO:0007155 325 0.018
regulation of mitotic cell cycle GO:0007346 189 0.018
purine nucleoside triphosphate catabolic process GO:0009146 392 0.018
cell development GO:0048468 328 0.018
regulation of protein localization GO:0032880 296 0.018
positive regulation of meiotic cell cycle GO:0051446 2 0.018
negative regulation of phosphate metabolic process GO:0045936 267 0.018
nucleoside phosphate catabolic process GO:1901292 412 0.018
cell growth GO:0016049 160 0.018
actin filament based process GO:0030029 224 0.018
anterior posterior axis specification GO:0009948 2 0.018
nuclear division GO:0000280 128 0.018
hindbrain development GO:0030902 3 0.018
establishment of protein localization to organelle GO:0072594 172 0.018
protein alkylation GO:0008213 74 0.018
glycosyl compound catabolic process GO:1901658 413 0.017
regulation of cell cycle phase transition GO:1901987 126 0.017
blastoderm segmentation GO:0007350 2 0.017
membrane organization GO:0061024 292 0.017
regulation of cellular response to stress GO:0080135 244 0.017
meiotic chromosome segregation GO:0045132 4 0.017
nucleoside triphosphate catabolic process GO:0009143 394 0.017
regulation of nucleotide metabolic process GO:0006140 269 0.017
positive regulation of phosphorylation GO:0042327 394 0.017
regulation of kinase activity GO:0043549 314 0.017
single organism cellular localization GO:1902580 332 0.017
positive regulation of cell proliferation GO:0008284 301 0.017
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.017
protein maturation GO:0051604 233 0.017
regulation of anatomical structure morphogenesis GO:0022603 286 0.017
protein processing GO:0016485 226 0.017
organelle fission GO:0048285 149 0.017
regulation of synaptic plasticity GO:0048167 3 0.017
oocyte development GO:0048599 1 0.016
dephosphorylation GO:0016311 209 0.016
regulation of cellular component movement GO:0051270 334 0.016
positive regulation of programmed cell death GO:0043068 249 0.016
signal transduction by phosphorylation GO:0023014 297 0.016
negative regulation of programmed cell death GO:0043069 321 0.016
ion transmembrane transport GO:0034220 338 0.016
regulation of cell cycle process GO:0010564 266 0.016
positive regulation of catabolic process GO:0009896 310 0.016
organonitrogen compound biosynthetic process GO:1901566 200 0.016
chromatin silencing GO:0006342 12 0.016
carbohydrate derivative biosynthetic process GO:1901137 207 0.016
positive regulation of nucleotide metabolic process GO:0045981 230 0.016
intracellular protein transport GO:0006886 270 0.016
regulation of protein stability GO:0031647 87 0.016
regulation of protein kinase activity GO:0045859 289 0.016
embryonic epithelial tube formation GO:0001838 4 0.016
lipid biosynthetic process GO:0008610 177 0.015
cation transport GO:0006812 331 0.015
regulation of chromosome organization GO:0033044 103 0.015
apoptotic signaling pathway GO:0097190 268 0.015
chemical homeostasis GO:0048878 306 0.015
regulation of cell motility GO:2000145 299 0.015
ion homeostasis GO:0050801 230 0.015
organophosphate biosynthetic process GO:0090407 163 0.015
protein modification by small protein conjugation GO:0032446 342 0.015
positive regulation of protein phosphorylation GO:0001934 313 0.015
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.015
positive regulation of immune system process GO:0002684 283 0.015
secretion GO:0046903 254 0.015
response to oxygen containing compound GO:1901700 369 0.015
negative regulation of apoptotic process GO:0043066 316 0.015
negative regulation of cellular amine metabolic process GO:0033239 3 0.015
maintenance of location GO:0051235 112 0.015
ubiquitin dependent protein catabolic process GO:0006511 206 0.015
tripartite regional subdivision GO:0007351 2 0.015
endomembrane system organization GO:0010256 196 0.014
rhythmic behavior GO:0007622 2 0.014
positive regulation of cell death GO:0010942 263 0.014
guanosine containing compound catabolic process GO:1901069 239 0.014
substantia nigra development GO:0021762 45 0.014
cellular homeostasis GO:0019725 196 0.014
metal ion transport GO:0030001 272 0.014
regulation of purine nucleotide metabolic process GO:1900542 264 0.014
associative learning GO:0008306 1 0.014
negative regulation of cell death GO:0060548 345 0.014
negative regulation of protein modification process GO:0031400 200 0.014
positive regulation of transferase activity GO:0051347 227 0.014
cation transmembrane transport GO:0098655 238 0.014
cellular protein catabolic process GO:0044257 261 0.014
response to fungus GO:0009620 4 0.014
reactive nitrogen species metabolic process GO:2001057 3 0.014
growth GO:0040007 202 0.014
system process GO:0003008 349 0.014
reproductive process GO:0022414 106 0.014
response to axon injury GO:0048678 1 0.014
motor neuron axon guidance GO:0008045 2 0.014
spermatid development GO:0007286 4 0.013
circadian behavior GO:0048512 2 0.013
secretion by cell GO:0032940 226 0.013
guanosine containing compound metabolic process GO:1901068 244 0.013
regulation of establishment of protein localization GO:0070201 242 0.013
gtp metabolic process GO:0046039 239 0.013
regulation of neural precursor cell proliferation GO:2000177 4 0.013
proteasomal protein catabolic process GO:0010498 176 0.013
regulation of locomotion GO:0040012 329 0.013
regulation of chromatin modification GO:1903308 51 0.013
carbohydrate metabolic process GO:0005975 207 0.013
single organism cell adhesion GO:0098602 179 0.013
negative regulation of cell proliferation GO:0008285 228 0.013
spermatid differentiation GO:0048515 4 0.013
regulation of cytokine production GO:0001817 232 0.013
regulation of intracellular transport GO:0032386 195 0.013
cardiac muscle cell contraction GO:0086003 4 0.013
regulation of cellular component biogenesis GO:0044087 281 0.013
metencephalon development GO:0022037 2 0.013
actin mediated cell contraction GO:0070252 12 0.013
cellular chemical homeostasis GO:0055082 180 0.013
limbic system development GO:0021761 3 0.013
rna interference GO:0016246 4 0.013
mapk cascade GO:0000165 288 0.013
positive regulation of kinase activity GO:0033674 204 0.013
mating GO:0007618 1 0.013
protein methylation GO:0006479 74 0.013
neurotransmitter secretion GO:0007269 4 0.013
regulation of mapk cascade GO:0043408 262 0.013
compound eye development GO:0048749 1 0.013
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.013
modification dependent macromolecule catabolic process GO:0043632 212 0.013
regulation of secretion GO:0051046 194 0.013
ribonucleoside catabolic process GO:0042454 406 0.013
nervous system development GO:0007399 293 0.013
inner ear morphogenesis GO:0042472 4 0.013
regulation of nuclear division GO:0051783 65 0.013
negative regulation of hydrolase activity GO:0051346 182 0.013
adult locomotory behavior GO:0008344 1 0.013
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.013
positive regulation of nucleotide catabolic process GO:0030813 185 0.013
nucleoside monophosphate metabolic process GO:0009123 191 0.013
positive regulation of apoptotic process GO:0043065 246 0.013
protein oligomerization GO:0051259 173 0.013
positive regulation of nucleoside metabolic process GO:0045979 186 0.012
cell fate determination GO:0001709 3 0.012
regulation of response to external stimulus GO:0032101 222 0.012
cytokine production GO:0001816 247 0.012
mitotic cell cycle process GO:1903047 286 0.012
positive regulation of developmental process GO:0051094 314 0.012
regulation of protein transport GO:0051223 213 0.012
purine nucleoside monophosphate metabolic process GO:0009126 186 0.012
organ formation GO:0048645 3 0.012
cellular protein complex assembly GO:0043623 188 0.012
nitrogen compound transport GO:0071705 191 0.012
regulation of histone modification GO:0031056 47 0.012
regulation of nucleotide catabolic process GO:0030811 205 0.012
regulation of protein catabolic process GO:0042176 155 0.012
tissue regeneration GO:0042246 3 0.012
oxidation reduction process GO:0055114 396 0.012
cation homeostasis GO:0055080 189 0.012
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.012
enzyme linked receptor protein signaling pathway GO:0007167 303 0.012
chromosome segregation GO:0007059 114 0.012
multi organism cellular process GO:0044764 156 0.012
regulation of purine nucleotide catabolic process GO:0033121 205 0.012
response to lipid GO:0033993 206 0.012
sensory perception of pain GO:0019233 4 0.012
inorganic cation transmembrane transport GO:0098662 194 0.012
positive regulation of protein kinase activity GO:0045860 190 0.012
protein localization to membrane GO:0072657 160 0.012
regulation of cell migration GO:0030334 289 0.012
positive regulation of cellular component movement GO:0051272 181 0.012
cell division GO:0051301 168 0.012
atp metabolic process GO:0046034 176 0.012
stem cell division GO:0017145 2 0.012
peripheral nervous system development GO:0007422 2 0.012
nerve development GO:0021675 4 0.012
reactive oxygen species metabolic process GO:0072593 75 0.012
ribonucleoside monophosphate metabolic process GO:0009161 187 0.012
syncytium formation by plasma membrane fusion GO:0000768 2 0.012
cellular ion homeostasis GO:0006873 168 0.012
protein localization to chromatin GO:0071168 11 0.012
monocarboxylic acid metabolic process GO:0032787 185 0.011
negative regulation of cellular component organization GO:0051129 235 0.011
cellular response to light stimulus GO:0071482 34 0.011
gtp catabolic process GO:0006184 237 0.011
negative regulation of phosphorylation GO:0042326 174 0.011
small molecule biosynthetic process GO:0044283 157 0.011
neurological system process GO:0050877 163 0.011
reactive oxygen species biosynthetic process GO:1903409 4 0.011
protein stabilization GO:0050821 64 0.011
tube closure GO:0060606 3 0.011
negative regulation of protein processing GO:0010955 142 0.011
positive regulation of neural precursor cell proliferation GO:2000179 2 0.011
regulation of nucleoside metabolic process GO:0009118 209 0.011
positive regulation of cell cycle GO:0045787 140 0.011
regulation of secretion by cell GO:1903530 177 0.011
cellular response to oxygen containing compound GO:1901701 276 0.011
regulation of protein serine threonine kinase activity GO:0071900 179 0.011
microtubule based process GO:0007017 210 0.011
spinal cord development GO:0021510 4 0.011
morphogenesis of a polarized epithelium GO:0001738 3 0.011
long term memory GO:0007616 2 0.011
somatic stem cell maintenance GO:0035019 4 0.011
positive regulation of mapk cascade GO:0043410 190 0.011
cellular cation homeostasis GO:0030003 163 0.011
cellular response to endogenous stimulus GO:0071495 336 0.011
establishment of protein localization to membrane GO:0090150 121 0.011
protein targeting GO:0006605 187 0.011
cerebellum development GO:0021549 2 0.011
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.011
lung alveolus development GO:0048286 4 0.011
negative regulation of gliogenesis GO:0014014 3 0.011
negative regulation of organelle organization GO:0010639 126 0.011
somitogenesis GO:0001756 2 0.011
positive regulation of cell migration GO:0030335 172 0.011
negative regulation of mitotic cell cycle GO:0045930 102 0.011
cellular component morphogenesis GO:0032989 314 0.011
negative regulation of transport GO:0051051 176 0.011
reproduction GO:0000003 63 0.011
negative regulation of catabolic process GO:0009895 104 0.011
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.011
angiogenesis GO:0001525 147 0.011
regulation of endopeptidase activity GO:0052548 170 0.011
response to cytokine GO:0034097 232 0.011
visual behavior GO:0007632 2 0.011
modification dependent protein catabolic process GO:0019941 209 0.011
specification of organ identity GO:0010092 3 0.011
regulation of vesicle mediated transport GO:0060627 130 0.011
regulation of peptidase activity GO:0052547 180 0.011
mitotic cell cycle phase transition GO:0044772 162 0.011
response to activity GO:0014823 0 0.011
positive regulation of cellular component biogenesis GO:0044089 158 0.011
photoreceptor cell differentiation GO:0046530 2 0.011
cell projection organization GO:0030030 252 0.011
regulation of cytoskeleton organization GO:0051493 177 0.011
regulation of dna metabolic process GO:0051052 153 0.011
negative regulation of proteolysis GO:0045861 132 0.011
actin cytoskeleton organization GO:0030036 207 0.011
negative regulation of intracellular signal transduction GO:1902532 183 0.011
response to inorganic substance GO:0010035 127 0.011
cardiovascular system development GO:0072358 262 0.011
cell morphogenesis GO:0000902 296 0.011
regulation of ras protein signal transduction GO:0046578 155 0.011
regulation of gtpase activity GO:0043087 180 0.011
regulation of ras gtpase activity GO:0032318 128 0.011
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.011
sex determination GO:0007530 3 0.011
neuroblast proliferation GO:0007405 4 0.010
single organism carbohydrate metabolic process GO:0044723 193 0.010
cellular response to cytokine stimulus GO:0071345 181 0.010
response to hormone GO:0009725 175 0.010
positive regulation of cell differentiation GO:0045597 211 0.010
salivary gland morphogenesis GO:0007435 4 0.010
regulation of immune response GO:0050776 201 0.010
positive regulation of gtpase activity GO:0043547 166 0.010
regulation of cytoplasmic transport GO:1903649 149 0.010
organic acid biosynthetic process GO:0016053 97 0.010
actin filament based movement GO:0030048 17 0.010
t cell differentiation in thymus GO:0033077 4 0.010
metal ion homeostasis GO:0055065 169 0.010
cell projection assembly GO:0030031 126 0.010
response to organic cyclic compound GO:0014070 204 0.010
anterior posterior axis specification embryo GO:0008595 2 0.010
establishment or maintenance of bipolar cell polarity GO:0061245 2 0.010
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.010
nucleus localization GO:0051647 1 0.010
positive regulation of locomotion GO:0040017 186 0.010
intrinsic apoptotic signaling pathway GO:0097193 127 0.010
vasodilation GO:0042311 4 0.010
regulation of protein maturation GO:1903317 150 0.010
establishment or maintenance of apical basal cell polarity GO:0035088 2 0.010
epidermis morphogenesis GO:0048730 3 0.010
nucleocytoplasmic transport GO:0006913 176 0.010

HIST1H2BC disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.026
disease of cellular proliferation DOID:14566 174 0.020
musculoskeletal system disease DOID:17 223 0.019
cancer DOID:162 167 0.019
inherited metabolic disorder DOID:655 242 0.019
nervous system disease DOID:863 431 0.018
sensory system disease DOID:0050155 203 0.018
organ system cancer DOID:0050686 164 0.017
central nervous system disease DOID:331 186 0.017
retinal disease DOID:5679 118 0.013
eye and adnexa disease DOID:1492 150 0.013
eye disease DOID:5614 149 0.013
connective tissue disease DOID:65 109 0.013
neurodegenerative disease DOID:1289 102 0.013
muscle tissue disease DOID:66 113 0.012
muscular disease DOID:0080000 114 0.012
myopathy DOID:423 104 0.012
bone disease DOID:0080001 88 0.011
retinal degeneration DOID:8466 89 0.010
brain disease DOID:936 73 0.010