Homo sapiens

21 known processes

HLA-DMA

major histocompatibility complex, class II, DM alpha

(Aliases: DMA,RING6,D6S222E,HLADM)

HLA-DMA biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
dendritic cell antigen processing and presentation GO:0002468 1 1.000
peptide antigen assembly with mhc class ii protein complex GO:0002503 4 1.000
polysaccharide assembly with mhc class ii protein complex GO:0002506 2 0.999
Human
peptide antigen assembly with mhc protein complex GO:0002501 4 0.999
antigen processing and presentation of peptide antigen GO:0048002 18 0.998
antigen processing and presentation of peptide antigen via mhc class ii GO:0002495 11 0.998
antigen processing and presentation of peptide or polysaccharide antigen via mhc class ii GO:0002504 12 0.998
positive regulation of myeloid leukocyte cytokine production involved in immune response GO:0061081 1 0.996
mhc protein complex assembly GO:0002396 4 0.995
regulation of interleukin 10 secretion GO:2001179 4 0.992
antigen processing and presentation GO:0019882 33 0.990
mhc class ii protein complex assembly GO:0002399 4 0.990
negative regulation of antigen processing and presentation GO:0002578 5 0.970
Human
regulation of t cell proliferation GO:0042129 42 0.955
protein carbohydrate complex subunit organization GO:0071823 2 0.953
Human
cytokine production GO:0001816 247 0.926
positive regulation of lymphocyte proliferation GO:0050671 46 0.905
regulation of t cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cell GO:2001188 2 0.905
protein carbohydrate complex assembly GO:0065006 2 0.904
Human
lymphocyte proliferation GO:0046651 70 0.898
de novo protein folding GO:0006458 2 0.889
Mouse
mononuclear cell proliferation GO:0032943 71 0.881
regulation of lymphocyte proliferation GO:0050670 64 0.865
peptide secretion GO:0002790 51 0.853
t helper 1 type immune response GO:0042088 8 0.844
cellular protein complex assembly GO:0043623 188 0.844
negative regulation of antigen processing and presentation of peptide antigen via mhc class ii GO:0002587 2 0.835
Human
inflammatory response to antigenic stimulus GO:0002437 4 0.804
regulation of leukocyte proliferation GO:0070663 67 0.794
regulation of mononuclear cell proliferation GO:0032944 65 0.776
leukocyte proliferation GO:0070661 74 0.767
detection of biotic stimulus GO:0009595 21 0.755
regulation of interferon gamma production GO:0032649 36 0.750
regulation of lymphocyte activation GO:0051249 103 0.742
Mouse
cellular macromolecular complex assembly GO:0034622 324 0.727
peptide transport GO:0015833 74 0.722
humoral immune response GO:0006959 49 0.718
Mouse
regulation of cell activation GO:0050865 125 0.712
Mouse
t cell proliferation GO:0042098 45 0.690
regulation of t cell activation GO:0050863 77 0.687
Mouse
cell activation GO:0001775 213 0.672
Mouse
immune response GO:0006955 307 0.668
Mouse
t cell activation GO:0042110 99 0.663
Mouse
positive regulation of leukocyte activation GO:0002696 80 0.647
Mouse
antigen processing and presentation of exogenous peptide antigen GO:0002478 4 0.646
Mouse
lymphocyte activation GO:0046649 133 0.644
Mouse
positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 3 0.633
negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via mhc class ii GO:0002581 3 0.629
Human
positive regulation of lymphocyte activation GO:0051251 73 0.626
Mouse
regulation of immune effector process GO:0002697 91 0.594
negative regulation of inflammatory response to antigenic stimulus GO:0002862 2 0.586
regulation of cytokine production GO:0001817 232 0.579
positive regulation of immune response GO:0050778 159 0.565
Mouse
regulation of defense response GO:0031347 154 0.548
interferon gamma production GO:0032609 39 0.547
positive regulation of cell activation GO:0050867 81 0.544
Mouse
response to glucose GO:0009749 19 0.542
innate immune response GO:0045087 178 0.540
regulation of leukocyte activation GO:0002694 115 0.540
Mouse
leukocyte activation GO:0045321 164 0.536
Mouse
defense response GO:0006952 315 0.528
positive regulation of insulin secretion GO:0032024 10 0.521
detection of chemical stimulus involved in sensory perception GO:0050907 33 0.509
response to hexose GO:0009746 20 0.507
negative regulation of t cell activation GO:0050868 18 0.494
negative regulation of antigen processing and presentation of peptide antigen GO:0002584 3 0.480
Human
antigen processing and presentation of exogenous antigen GO:0019884 4 0.473
Mouse
negative regulation of leukocyte differentiation GO:1902106 24 0.455
regulation of immune response GO:0050776 201 0.453
Mouse
positive regulation of immune system process GO:0002684 283 0.453
Mouse
negative regulation of defense response GO:0031348 47 0.441
leukocyte mediated immunity GO:0002443 59 0.436
Mouse
positive regulation of t cell proliferation GO:0042102 33 0.412
positive regulation of hormone secretion GO:0046887 25 0.412
humoral immune response mediated by circulating immunoglobulin GO:0002455 5 0.411
negative regulation of multicellular organismal process GO:0051241 317 0.408
cellular homeostasis GO:0019725 196 0.403
cellular response to interferon gamma GO:0071346 24 0.398
secretion by cell GO:0032940 226 0.386
regulation of antigen processing and presentation GO:0002577 6 0.380
Human
positive regulation of leukocyte proliferation GO:0070665 48 0.377
negative regulation of immune system process GO:0002683 136 0.367
Human
positive regulation of lymphocyte differentiation GO:0045621 13 0.352
Mouse
cytokine secretion GO:0050663 64 0.351
positive regulation of mononuclear cell proliferation GO:0032946 47 0.345
positive regulation of t cell activation GO:0050870 54 0.330
Mouse
response to oxygen containing compound GO:1901700 369 0.328
positive regulation of t cell differentiation GO:0045582 11 0.325
Mouse
regulation of response to wounding GO:1903034 101 0.322
positive regulation of secretion by cell GO:1903532 108 0.314
hormone secretion GO:0046879 65 0.300
positive regulation of peptide secretion GO:0002793 15 0.296
nitrogen compound transport GO:0071705 191 0.293
regulation of cell migration GO:0030334 289 0.292
interleukin 10 production GO:0032613 17 0.282
t cell selection GO:0045058 4 0.275
Mouse
amide transport GO:0042886 76 0.271
detection of stimulus GO:0051606 85 0.260
cellular response to ammonium ion GO:0071242 4 0.240
positive regulation of peptide hormone secretion GO:0090277 15 0.238
b cell homeostasis GO:0001782 1 0.237
regulation of inflammatory response to antigenic stimulus GO:0002861 2 0.236
positive regulation of cell proliferation GO:0008284 301 0.236
negative regulation of cell proliferation GO:0008285 228 0.232
cellular glucose homeostasis GO:0001678 11 0.232
lymphocyte mediated immunity GO:0002449 48 0.223
Mouse
regulation of protein secretion GO:0050708 86 0.221
production of molecular mediator of immune response GO:0002440 37 0.220
detection of external biotic stimulus GO:0098581 19 0.219
detection of other organism GO:0098543 13 0.214
negative regulation of response to external stimulus GO:0032102 83 0.204
antigen processing and presentation of exogenous peptide antigen via mhc class ii GO:0019886 4 0.199
Mouse
regulation of cellular ketone metabolic process GO:0010565 50 0.195
regulation of secretion by cell GO:1903530 177 0.195
response to bacterium GO:0009617 144 0.194
cellular response to glucose stimulus GO:0071333 10 0.193
response to external biotic stimulus GO:0043207 261 0.192
signal release GO:0023061 70 0.191
regulation of secretion GO:0051046 194 0.183
negative regulation of cell activation GO:0050866 33 0.181
regulation of proteolysis GO:0030162 293 0.170
response to monosaccharide GO:0034284 20 0.170
regulation of protein transport GO:0051223 213 0.170
inflammatory response GO:0006954 79 0.170
secretion GO:0046903 254 0.169
glucose homeostasis GO:0042593 31 0.164
positive regulation of secretion GO:0051047 116 0.164
regulation of peptide hormone secretion GO:0090276 41 0.162
interleukin 4 production GO:0032633 7 0.155
lymphocyte activation involved in immune response GO:0002285 20 0.150
cellular response to oxygen containing compound GO:1901701 276 0.149
negative regulation of t cell proliferation GO:0042130 8 0.148
carbohydrate homeostasis GO:0033500 31 0.141
negative regulation of response to wounding GO:1903035 47 0.136
chemokine c x c motif ligand 2 production GO:0072567 3 0.127
protein maturation GO:0051604 233 0.126
regulation of interleukin 4 production GO:0032673 7 0.120
unsaturated fatty acid metabolic process GO:0033559 37 0.115
cell cell signaling GO:0007267 155 0.113
regulation of chemokine c x c motif ligand 2 production GO:2000341 2 0.110
erk1 and erk2 cascade GO:0070371 104 0.109
t cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cell GO:0002291 4 0.109
regulation of inflammatory response GO:0050727 46 0.105
positive regulation of protein kinase activity GO:0045860 190 0.105
regulation of protein processing GO:0070613 150 0.104
regulation of protein localization GO:0032880 296 0.102
positive regulation of transport GO:0051050 336 0.099
negative regulation of lymphocyte activation GO:0051250 24 0.098
peptide hormone secretion GO:0030072 50 0.098
fatty acid derivative metabolic process GO:1901568 35 0.090
cellular chemical homeostasis GO:0055082 180 0.088
mapk cascade GO:0000165 288 0.086
regulation of hormone levels GO:0010817 125 0.086
protein oligomerization GO:0051259 173 0.084
cellular response to molecule of bacterial origin GO:0071219 62 0.084
regulation of apoptotic signaling pathway GO:2001233 175 0.081
signal transduction by phosphorylation GO:0023014 297 0.081
cellular response to hexose stimulus GO:0071331 10 0.081
chaperone mediated protein folding requiring cofactor GO:0051085 1 0.079
Mouse
negative regulation of catalytic activity GO:0043086 335 0.078
b cell mediated immunity GO:0019724 10 0.077
Mouse
neurological system process GO:0050877 163 0.077
Human
regulation of leukocyte differentiation GO:1902105 61 0.076
Mouse
hormone transport GO:0009914 68 0.074
negative regulation of lymphocyte proliferation GO:0050672 15 0.073
response to cytokine GO:0034097 232 0.072
hematopoietic or lymphoid organ development GO:0048534 186 0.072
Mouse
regulation of cell motility GO:2000145 299 0.072
negative regulation of leukocyte proliferation GO:0070664 16 0.072
protein secretion GO:0009306 98 0.070
positive regulation of cellular amine metabolic process GO:0033240 7 0.070
negative regulation of peptidase activity GO:0010466 91 0.067
protein tetramerization GO:0051262 47 0.065
negative regulation of cell death GO:0060548 345 0.065
insulin secretion GO:0030073 39 0.064
prostaglandin metabolic process GO:0006693 17 0.064
negative regulation of inflammatory response GO:0050728 22 0.064
positive regulation of response to external stimulus GO:0032103 88 0.063
cellular response to cytokine stimulus GO:0071345 181 0.063
leukocyte activation involved in immune response GO:0002366 30 0.061
regulation of establishment of protein localization GO:0070201 242 0.058
negative regulation of hydrolase activity GO:0051346 182 0.058
negative regulation of b cell apoptotic process GO:0002903 4 0.058
positive regulation of cytokine production GO:0001819 167 0.057
regulation of insulin secretion GO:0050796 33 0.056
regulation of production of molecular mediator of immune response GO:0002700 25 0.056
cytokine mediated signaling pathway GO:0019221 109 0.055
negative regulation of immune response GO:0050777 40 0.054
negative regulation of homeostatic process GO:0032845 59 0.053
cellular amine metabolic process GO:0044106 41 0.051
regulation of hormone secretion GO:0046883 57 0.046
positive regulation of immune effector process GO:0002699 40 0.044
posttranscriptional regulation of gene expression GO:0010608 213 0.044
azole transport GO:0045117 4 0.043
fatty acid derivative biosynthetic process GO:1901570 18 0.043
immunoglobulin production GO:0002377 12 0.042
positive regulation of homeostatic process GO:0032846 47 0.041
cellular amino acid metabolic process GO:0006520 116 0.041
immunoglobulin mediated immune response GO:0016064 10 0.039
Mouse
t cell activation involved in immune response GO:0002286 13 0.039
regulation of kinase activity GO:0043549 314 0.039
regulation of antigen processing and presentation of peptide antigen via mhc class ii GO:0002586 3 0.037
Human
regulation of neutrophil migration GO:1902622 10 0.036
taxis GO:0042330 157 0.035
interleukin 10 secretion GO:0072608 5 0.034
cell projection organization GO:0030030 252 0.034
regulation of cytokine secretion GO:0050707 57 0.033
post embryonic development GO:0009791 2 0.033
positive regulation of cellular component movement GO:0051272 181 0.032
regeneration GO:0031099 4 0.032
positive regulation of kinase activity GO:0033674 204 0.032
positive regulation of interferon gamma production GO:0032729 26 0.031
regulation of mature b cell apoptotic process GO:0002905 1 0.031
response to lipid GO:0033993 206 0.030
positive regulation of cell death GO:0010942 263 0.030
protein processing GO:0016485 226 0.030
cellular lipid metabolic process GO:0044255 303 0.030
regulation of homeostatic process GO:0032844 121 0.029
monocarboxylic acid biosynthetic process GO:0072330 67 0.029
system process GO:0003008 349 0.028
Human
regulation of response to external stimulus GO:0032101 222 0.028
amine metabolic process GO:0009308 44 0.028
regulation of complement activation lectin pathway GO:0001868 2 0.028
positive regulation of t helper 1 type immune response GO:0002827 4 0.027
cellular response to carbohydrate stimulus GO:0071322 11 0.027
negative regulation of cell differentiation GO:0045596 171 0.027
multicellular organismal aging GO:0010259 3 0.026
pyrimidine containing compound transmembrane transport GO:0072531 4 0.025
negative regulation of mononuclear cell proliferation GO:0032945 15 0.025
response to interferon gamma GO:0034341 39 0.025
negative regulation of leukocyte activation GO:0002695 26 0.025
response to biotic stimulus GO:0009607 276 0.025
response to molecule of bacterial origin GO:0002237 82 0.025
chemical homeostasis GO:0048878 306 0.024
negative regulation of cellular component organization GO:0051129 235 0.024
negative regulation of phosphatidylinositol 3 kinase signaling GO:0014067 4 0.024
generation of neurons GO:0048699 152 0.024
negative regulation of programmed cell death GO:0043069 321 0.023
biological adhesion GO:0022610 331 0.023
regulation of cellular response to stress GO:0080135 244 0.022
negative regulation of apoptotic signaling pathway GO:2001234 97 0.022
regulation of transferase activity GO:0051338 355 0.021
response to fungus GO:0009620 4 0.021
oogenesis GO:0048477 2 0.021
detection of bacterium GO:0016045 13 0.020
monocarboxylic acid metabolic process GO:0032787 185 0.020
response to corticosteroid GO:0031960 15 0.020
cognition GO:0050890 43 0.020
Human
cellular response to dna damage stimulus GO:0006974 379 0.020
regulation of cell development GO:0060284 161 0.019
endocytosis GO:0006897 159 0.019
regulation of cellular amino acid metabolic process GO:0006521 6 0.019
negative regulation of apoptotic process GO:0043066 316 0.019
chemokine c c motif ligand 21 signaling pathway GO:0038116 1 0.019
cation transport GO:0006812 331 0.019
positive regulation of cell migration GO:0030335 172 0.019
immune response regulating cell surface receptor signaling pathway GO:0002768 51 0.019
inositol lipid mediated signaling GO:0048017 55 0.019
determination of adult lifespan GO:0008340 2 0.019
negative regulation of transport GO:0051051 176 0.019
regulation of mapk cascade GO:0043408 262 0.018
cellular cation homeostasis GO:0030003 163 0.018
regulation of protein stability GO:0031647 87 0.018
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.018
negative regulation of protein metabolic process GO:0051248 391 0.017
response to carbohydrate GO:0009743 21 0.017
carbohydrate metabolic process GO:0005975 207 0.017
regulation of leukocyte chemotaxis GO:0002688 46 0.017
compound eye development GO:0048749 1 0.017
regulation of nucleotide metabolic process GO:0006140 269 0.017
lymphocyte apoptotic process GO:0070227 20 0.017
positive regulation of locomotion GO:0040017 186 0.017
cellular response to hormone stimulus GO:0032870 125 0.016
protein catabolic process GO:0030163 325 0.016
regulation of protein maturation GO:1903317 150 0.016
cellular response to oxidative stress GO:0034599 85 0.016
negative regulation of phosphorus metabolic process GO:0010563 267 0.016
negative regulation of intracellular signal transduction GO:1902532 183 0.015
ameboidal type cell migration GO:0001667 135 0.015
negative regulation of dendritic cell differentiation GO:2001199 2 0.015
negative regulation of cytokine production GO:0001818 82 0.015
cell development GO:0048468 328 0.015
modification dependent protein catabolic process GO:0019941 209 0.015
small molecule biosynthetic process GO:0044283 157 0.015
regulation of peptide secretion GO:0002791 42 0.014
response to organic cyclic compound GO:0014070 204 0.014
negative regulation of protein processing GO:0010955 142 0.014
ribonucleoside triphosphate catabolic process GO:0009203 391 0.014
lipid metabolic process GO:0006629 381 0.014
ras protein signal transduction GO:0007265 73 0.014
mitotic cell cycle GO:0000278 326 0.014
cellular protein catabolic process GO:0044257 261 0.014
cell type specific apoptotic process GO:0097285 125 0.014
regulation of interleukin 10 production GO:0032653 16 0.013
cellular amide metabolic process GO:0043603 69 0.013
nucleoside phosphate catabolic process GO:1901292 412 0.013
insulin secretion involved in cellular response to glucose stimulus GO:0035773 7 0.013
intrinsic apoptotic signaling pathway GO:0097193 127 0.013
regulation of lipopolysaccharide mediated signaling pathway GO:0031664 13 0.013
nucleoside triphosphate catabolic process GO:0009143 394 0.013
regulation of locomotion GO:0040012 329 0.012
positive regulation of behavior GO:0048520 60 0.012
organelle assembly GO:0070925 176 0.012
small gtpase mediated signal transduction GO:0007264 78 0.012
negative regulation of cellular protein metabolic process GO:0032269 353 0.012
maintenance of location GO:0051235 112 0.012
negative regulation of cell development GO:0010721 48 0.012
nervous system development GO:0007399 293 0.012
regulation of type 2 immune response GO:0002828 5 0.012
reactive oxygen species metabolic process GO:0072593 75 0.012
regulation of peptidase activity GO:0052547 180 0.012
cell morphogenesis GO:0000902 296 0.012
negative regulation of interferon gamma production GO:0032689 9 0.012
positive regulation of mapk cascade GO:0043410 190 0.012
ubiquitin dependent protein catabolic process GO:0006511 206 0.012
negative regulation of phosphate metabolic process GO:0045936 267 0.012
regulation of camp metabolic process GO:0030814 52 0.012
regulation of vasculature development GO:1901342 97 0.012
cellular macromolecule catabolic process GO:0044265 380 0.012
cell cycle arrest GO:0007050 71 0.012
intracellular protein transport GO:0006886 270 0.012
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.011
regulation of cellular amine metabolic process GO:0033238 11 0.011
growth GO:0040007 202 0.011
epithelial cell proliferation GO:0050673 128 0.011
response to other organism GO:0051707 261 0.011
response to nitrogen compound GO:1901698 184 0.011
regulation of t helper 1 type immune response GO:0002825 5 0.011
regulation of neurogenesis GO:0050767 82 0.011
organophosphate catabolic process GO:0046434 430 0.011
multicellular organismal metabolic process GO:0044236 34 0.011
response to abiotic stimulus GO:0009628 336 0.011
positive regulation of cellular component organization GO:0051130 376 0.011
single organism carbohydrate metabolic process GO:0044723 193 0.011
regulation of cellular component movement GO:0051270 334 0.011
memory GO:0007613 3 0.011
positive regulation of adaptive immune response GO:0002821 21 0.011
Mouse
positive regulation of phosphorylation GO:0042327 394 0.011
response to dexamethasone GO:0071548 1 0.011
regulation of protein catabolic process GO:0042176 155 0.011
protein modification by small protein conjugation GO:0032446 342 0.011
cellular response to glucocorticoid stimulus GO:0071385 4 0.011
regulation of intracellular transport of viral material GO:1901252 2 0.011
regulation of anatomical structure size GO:0090066 101 0.011
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.011
cellular response to organonitrogen compound GO:0071417 124 0.011
regulation of t cell tolerance induction GO:0002664 4 0.011
mitotic cell cycle phase transition GO:0044772 162 0.010
regulation of chemotaxis GO:0050920 74 0.010
negative regulation of chemotaxis GO:0050922 13 0.010
protein ubiquitination GO:0016567 314 0.010
positive regulation of transferase activity GO:0051347 227 0.010
negative regulation of calcium ion import GO:0090281 1 0.010
neuron development GO:0048666 113 0.010
cell growth GO:0016049 160 0.010
protein polyubiquitination GO:0000209 110 0.010
cell activation involved in immune response GO:0002263 30 0.010

HLA-DMA disease predictions

Disease DO term ID Size Probability Func Analog Org
bone disease DOID:0080001 88 0.992
musculoskeletal system disease DOID:17 223 0.992
connective tissue disease DOID:65 109 0.992
immune system disease DOID:2914 155 0.991
Human
central nervous system disease DOID:331 186 0.929
neurodegenerative disease DOID:1289 102 0.929
nervous system disease DOID:863 431 0.929
hypersensitivity reaction disease DOID:0060056 25 0.836
Human
bone inflammation disease DOID:3342 10 0.104
arthritis DOID:848 8 0.104
rheumatoid arthritis DOID:7148 8 0.031
disease of metabolism DOID:0014667 295 0.028
inherited metabolic disorder DOID:655 242 0.025
primary immunodeficiency disease DOID:612 36 0.018
lysosomal storage disease DOID:3211 47 0.010