Homo sapiens

230 known processes

HLA-DRB1

major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1

(Aliases: FLJ76359,HLA-DRB,HLA-DRB1*,SS1,HLA-DR1B,DRw10,FLJ75017,DRB1)

HLA-DRB1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
dendritic cell antigen processing and presentation GO:0002468 1 1.000
peptide antigen assembly with mhc protein complex GO:0002501 4 1.000
antigen processing and presentation of peptide antigen via mhc class ii GO:0002495 11 1.000
peptide antigen assembly with mhc class ii protein complex GO:0002503 4 1.000
polysaccharide assembly with mhc class ii protein complex GO:0002506 2 1.000
antigen processing and presentation of peptide antigen GO:0048002 18 1.000
negative regulation of antigen processing and presentation GO:0002578 5 1.000
antigen processing and presentation of peptide or polysaccharide antigen via mhc class ii GO:0002504 12 0.999
protein carbohydrate complex subunit organization GO:0071823 2 0.999
antigen processing and presentation GO:0019882 33 0.999
antigen processing and presentation of exogenous peptide antigen via mhc class ii GO:0019886 4 0.998
mhc protein complex assembly GO:0002396 4 0.997
positive regulation of myeloid leukocyte cytokine production involved in immune response GO:0061081 1 0.995
mhc class ii protein complex assembly GO:0002399 4 0.994
regulation of antigen processing and presentation of peptide antigen via mhc class ii GO:0002586 3 0.994
de novo protein folding GO:0006458 2 0.992
antigen processing and presentation of polysaccharide antigen via mhc class ii GO:0002505 2 0.992
regulation of interleukin 10 secretion GO:2001179 4 0.987
cellular response to ammonium ion GO:0071242 4 0.975
humoral immune response GO:0006959 49 0.968
regulation of t cell proliferation GO:0042129 42 0.966
lymphocyte mediated immunity GO:0002449 48 0.937
peptide transport GO:0015833 74 0.935
lymphocyte proliferation GO:0046651 70 0.916
positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 3 0.909
negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via mhc class ii GO:0002581 3 0.909
positive regulation of lymphocyte proliferation GO:0050671 46 0.908
regulation of cell activation GO:0050865 125 0.894
positive regulation of leukocyte proliferation GO:0070665 48 0.890
regulation of lymphocyte proliferation GO:0050670 64 0.889
regulation of t cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cell GO:2001188 2 0.886
cellular macromolecular complex assembly GO:0034622 324 0.882
leukocyte mediated immunity GO:0002443 59 0.882
regulation of leukocyte proliferation GO:0070663 67 0.868
cytokine production GO:0001816 247 0.868
antigen processing and presentation of exogenous peptide antigen GO:0002478 4 0.861
positive regulation of t cell activation GO:0050870 54 0.836
regulation of defense response GO:0031347 154 0.831
cellular protein complex assembly GO:0043623 188 0.829
positive regulation of immune response GO:0050778 159 0.826
t helper 1 type immune response GO:0042088 8 0.809
immune response GO:0006955 307 0.807
regulation of lymphocyte activation GO:0051249 103 0.796
cellular homeostasis GO:0019725 196 0.795
positive regulation of lymphocyte differentiation GO:0045621 13 0.785
nitrogen compound transport GO:0071705 191 0.778
positive regulation of lymphocyte activation GO:0051251 73 0.771
negative regulation of response to external stimulus GO:0032102 83 0.758
regulation of cytokine production GO:0001817 232 0.744
cell activation GO:0001775 213 0.728
regulation of response to wounding GO:1903034 101 0.716
peptide secretion GO:0002790 51 0.707
leukocyte activation GO:0045321 164 0.707
negative regulation of defense response GO:0031348 47 0.705
t cell activation GO:0042110 99 0.704
signal release GO:0023061 70 0.699
negative regulation of antigen processing and presentation of peptide antigen via mhc class ii GO:0002587 2 0.698
positive regulation of leukocyte activation GO:0002696 80 0.697
regulation of t cell activation GO:0050863 77 0.689
positive regulation of hormone secretion GO:0046887 25 0.681
positive regulation of cell activation GO:0050867 81 0.679
detection of other organism GO:0098543 13 0.677
humoral immune response mediated by circulating immunoglobulin GO:0002455 5 0.672
negative regulation of antigen processing and presentation of peptide antigen GO:0002584 3 0.670
immunoglobulin mediated immune response GO:0016064 10 0.664
t cell selection GO:0045058 4 0.660
regulation of interleukin 4 production GO:0032673 7 0.653
secretion GO:0046903 254 0.642
detection of external biotic stimulus GO:0098581 19 0.640
positive regulation of leukocyte differentiation GO:1902107 37 0.633
detection of biotic stimulus GO:0009595 21 0.627
leukocyte proliferation GO:0070661 74 0.621
lymphocyte activation GO:0046649 133 0.610
regulation of immune response GO:0050776 201 0.610
positive regulation of cytokine production GO:0001819 167 0.588
positive regulation of peptide hormone secretion GO:0090277 15 0.587
regulation of leukocyte activation GO:0002694 115 0.581
response to hexose GO:0009746 20 0.580
hormone secretion GO:0046879 65 0.567
cellular glucose homeostasis GO:0001678 11 0.565
positive regulation of t cell differentiation GO:0045582 11 0.559
positive regulation of adaptive immune response GO:0002821 21 0.549
cellular lipid metabolic process GO:0044255 303 0.547
cellular response to interferon gamma GO:0071346 24 0.542
regulation of insulin secretion GO:0050796 33 0.532
innate immune response GO:0045087 178 0.527
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 29 0.505
regulation of interferon gamma production GO:0032649 36 0.504
cellular response to glucose stimulus GO:0071333 10 0.502
defense response GO:0006952 315 0.490
positive thymic t cell selection GO:0045059 1 0.484
positive regulation of immune system process GO:0002684 283 0.483
regulation of protein transport GO:0051223 213 0.482
thymic t cell selection GO:0045061 2 0.465
mononuclear cell proliferation GO:0032943 71 0.454
regulation of cell migration GO:0030334 289 0.453
interleukin 4 production GO:0032633 7 0.416
positive regulation of secretion GO:0051047 116 0.396
leukocyte differentiation GO:0002521 98 0.389
inflammatory response to antigenic stimulus GO:0002437 4 0.388
detection of chemical stimulus involved in sensory perception GO:0050907 33 0.379
regulation of chemotaxis GO:0050920 74 0.356
regulation of antigen processing and presentation GO:0002577 6 0.349
negative regulation of immune system process GO:0002683 136 0.341
positive regulation of insulin secretion GO:0032024 10 0.339
hematopoietic or lymphoid organ development GO:0048534 186 0.334
cellular response to oxygen containing compound GO:1901701 276 0.326
system process GO:0003008 349 0.311
negative regulation of lymphocyte activation GO:0051250 24 0.298
positive regulation of mononuclear cell proliferation GO:0032946 47 0.298
response to fungus GO:0009620 4 0.291
positive regulation of t cell proliferation GO:0042102 33 0.281
t cell proliferation GO:0042098 45 0.268
b cell homeostasis GO:0001782 1 0.264
de novo posttranslational protein folding GO:0051084 2 0.251
response to oxygen containing compound GO:1901700 369 0.242
regulation of antigen processing and presentation of peptide or polysaccharide antigen via mhc class ii GO:0002580 4 0.238
regulation of cell differentiation GO:0045595 393 0.210
response to bacterium GO:0009617 144 0.210
hemopoiesis GO:0030097 180 0.195
immune system development GO:0002520 195 0.189
cytokine secretion GO:0050663 64 0.185
positive regulation of protein kinase activity GO:0045860 190 0.175
prostaglandin biosynthetic process GO:0001516 11 0.169
interleukin 10 production GO:0032613 17 0.169
positive regulation of cell proliferation GO:0008284 301 0.152
negative regulation of immune response GO:0050777 40 0.151
regulation of adaptive immune response GO:0002819 33 0.147
cellular amine metabolic process GO:0044106 41 0.146
lymphocyte differentiation GO:0030098 35 0.145
positive regulation of peptide secretion GO:0002793 15 0.144
protein maturation GO:0051604 233 0.142
unsaturated fatty acid biosynthetic process GO:0006636 21 0.140
antigen processing and presentation of exogenous antigen GO:0019884 4 0.139
negative regulation of cell proliferation GO:0008285 228 0.137
fibroblast proliferation GO:0048144 33 0.132
protein oligomerization GO:0051259 173 0.128
cell projection organization GO:0030030 252 0.126
regulation of secretion by cell GO:1903530 177 0.120
response to cytokine GO:0034097 232 0.120
regulation of protein secretion GO:0050708 86 0.118
negative regulation of t cell activation GO:0050868 18 0.114
regulation of leukocyte differentiation GO:1902105 61 0.110
neurological system process GO:0050877 163 0.109
chaperone mediated protein folding GO:0061077 13 0.103
chaperone mediated protein folding requiring cofactor GO:0051085 1 0.102
positive regulation of developmental process GO:0051094 314 0.101
chemokine c x c motif ligand 2 production GO:0072567 3 0.098
protein secretion GO:0009306 98 0.094
regulation of apoptotic signaling pathway GO:2001233 175 0.093
cytokine mediated signaling pathway GO:0019221 109 0.088
negative regulation of catalytic activity GO:0043086 335 0.087
regulation of peptide hormone secretion GO:0090276 41 0.087
regulation of cellular ketone metabolic process GO:0010565 50 0.086
positive regulation of neutrophil chemotaxis GO:0090023 7 0.086
regulation of immune effector process GO:0002697 91 0.084
regulation of hormone levels GO:0010817 125 0.083
positive regulation of cellular amine metabolic process GO:0033240 7 0.079
negative regulation of peptidase activity GO:0010466 91 0.078
cellular response to cytokine stimulus GO:0071345 181 0.076
t cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cell GO:0002291 4 0.075
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 19 0.074
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 37 0.072
negative regulation of inflammatory response to antigenic stimulus GO:0002862 2 0.068
unsaturated fatty acid metabolic process GO:0033559 37 0.067
immunoglobulin production GO:0002377 12 0.064
regulation of inflammatory response GO:0050727 46 0.064
negative regulation of lymphocyte apoptotic process GO:0070229 8 0.063
positive t cell selection GO:0043368 2 0.063
cellular response to molecule of bacterial origin GO:0071219 62 0.061
response to external biotic stimulus GO:0043207 261 0.059
fatty acid derivative metabolic process GO:1901568 35 0.059
mapk cascade GO:0000165 288 0.058
detection of bacterium GO:0016045 13 0.058
leukocyte activation involved in immune response GO:0002366 30 0.058
cellular response to monosaccharide stimulus GO:0071326 10 0.057
regulation of complement activation lectin pathway GO:0001868 2 0.055
positive regulation of humoral immune response GO:0002922 3 0.054
regulation of neutrophil migration GO:1902622 10 0.054
negative regulation of b cell apoptotic process GO:0002903 4 0.054
regulation of anatomical structure morphogenesis GO:0022603 286 0.051
negative regulation of cell activation GO:0050866 33 0.051
hormone transport GO:0009914 68 0.051
secretion by cell GO:0032940 226 0.050
taxis GO:0042330 157 0.050
regulation of secretion GO:0051046 194 0.049
negative regulation of cell differentiation GO:0045596 171 0.049
positive regulation of t helper 1 type immune response GO:0002827 4 0.049
cellular amino acid metabolic process GO:0006520 116 0.046
actin filament based process GO:0030029 224 0.045
amine metabolic process GO:0009308 44 0.045
amide transport GO:0042886 76 0.045
b cell mediated immunity GO:0019724 10 0.044
t cell activation involved in immune response GO:0002286 13 0.043
insulin secretion GO:0030073 39 0.042
positive regulation of transport GO:0051050 336 0.041
glucose homeostasis GO:0042593 31 0.041
post embryonic development GO:0009791 2 0.040
regulation of kinase activity GO:0043549 314 0.040
intrinsic apoptotic signaling pathway GO:0097193 127 0.039
monocarboxylic acid biosynthetic process GO:0072330 67 0.039
regulation of establishment of protein localization GO:0070201 242 0.039
negative regulation of hydrolase activity GO:0051346 182 0.038
positive regulation of kinase activity GO:0033674 204 0.037
posttranscriptional regulation of gene expression GO:0010608 213 0.037
positive regulation of secretion by cell GO:1903532 108 0.036
regulation of peptidase activity GO:0052547 180 0.036
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 85 0.035
regulation of leukocyte chemotaxis GO:0002688 46 0.035
positive regulation of cell migration GO:0030335 172 0.034
regulation of protein localization GO:0032880 296 0.033
protein tetramerization GO:0051262 47 0.033
negative regulation of multicellular organismal process GO:0051241 317 0.033
positive regulation of phosphorylation GO:0042327 394 0.032
peptide hormone secretion GO:0030072 50 0.032
sensory perception of chemical stimulus GO:0007606 38 0.032
regulation of lymphocyte differentiation GO:0045619 22 0.032
response to corticosteroid GO:0031960 15 0.032
positive regulation of response to external stimulus GO:0032103 88 0.032
chemical homeostasis GO:0048878 306 0.031
receptor metabolic process GO:0043112 81 0.031
response to carbohydrate GO:0009743 21 0.031
negative regulation of t cell proliferation GO:0042130 8 0.030
negative regulation of apoptotic process GO:0043066 316 0.029
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.029
regulation of cellular amine metabolic process GO:0033238 11 0.029
regulation of protein kinase activity GO:0045859 289 0.029
t cell differentiation in thymus GO:0033077 4 0.029
regulation of proteolysis GO:0030162 293 0.028
negative regulation of cytolysis GO:0045918 3 0.028
azole transport GO:0045117 4 0.028
response to organic cyclic compound GO:0014070 204 0.027
regulation of cell motility GO:2000145 299 0.027
positive regulation of production of molecular mediator of immune response GO:0002702 11 0.027
negative regulation of cellular component organization GO:0051129 235 0.027
regulation of inflammatory response to antigenic stimulus GO:0002861 2 0.027
prostanoid biosynthetic process GO:0046457 11 0.027
response to biotic stimulus GO:0009607 276 0.027
negative regulation of cellular protein metabolic process GO:0032269 353 0.026
fatty acid derivative biosynthetic process GO:1901570 18 0.026
cation transport GO:0006812 331 0.025
negative regulation of leukocyte proliferation GO:0070664 16 0.025
negative regulation of cell death GO:0060548 345 0.025
response to other organism GO:0051707 261 0.024
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.024
endocytosis GO:0006897 159 0.023
carbohydrate homeostasis GO:0033500 31 0.023
multicellular organismal aging GO:0010259 3 0.023
negative regulation of leukocyte differentiation GO:1902106 24 0.023
regulation of transferase activity GO:0051338 355 0.023
positive regulation of cell death GO:0010942 263 0.023
regulation of mononuclear cell proliferation GO:0032944 65 0.023
response to interferon gamma GO:0034341 39 0.023
interspecies interaction between organisms GO:0044419 156 0.023
production of molecular mediator of immune response GO:0002440 37 0.022
negative regulation of apoptotic signaling pathway GO:2001234 97 0.022
cognition GO:0050890 43 0.022
cellular cation homeostasis GO:0030003 163 0.021
negative regulation of programmed cell death GO:0043069 321 0.021
cell type specific apoptotic process GO:0097285 125 0.021
protein ubiquitination GO:0016567 314 0.021
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.021
protein processing GO:0016485 226 0.021
nucleoside triphosphate catabolic process GO:0009143 394 0.021
cellular response to dna damage stimulus GO:0006974 379 0.021
regulation of cellular component movement GO:0051270 334 0.020
immune effector process GO:0002252 159 0.020
cell cell signaling GO:0007267 155 0.019
regulation of cell development GO:0060284 161 0.019
regulation of peptide secretion GO:0002791 42 0.019
signal transduction by phosphorylation GO:0023014 297 0.019
negative regulation of leukocyte activation GO:0002695 26 0.019
positive regulation of locomotion GO:0040017 186 0.019
inositol lipid mediated signaling GO:0048017 55 0.019
lipid metabolic process GO:0006629 381 0.018
protein modification by small protein conjugation GO:0032446 342 0.018
generation of neurons GO:0048699 152 0.018
positive regulation of cell differentiation GO:0045597 211 0.018
negative regulation of protein metabolic process GO:0051248 391 0.018
t cell differentiation GO:0030217 29 0.018
biological adhesion GO:0022610 331 0.018
response to molecule of bacterial origin GO:0002237 82 0.017
leukocyte migration GO:0050900 107 0.017
ras protein signal transduction GO:0007265 73 0.017
positive regulation of transferase activity GO:0051347 227 0.017
sensory organ development GO:0007423 52 0.017
positive regulation of b cell activation GO:0050871 17 0.017
regulation of humoral immune response GO:0002920 11 0.017
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.017
cell adhesion GO:0007155 325 0.017
response to wounding GO:0009611 168 0.017
cell development GO:0048468 328 0.017
cellular chemical homeostasis GO:0055082 180 0.017
positive regulation of ion transport GO:0043270 87 0.017
regulation of locomotion GO:0040012 329 0.016
negative regulation of response to wounding GO:1903035 47 0.016
negative regulation of locomotion GO:0040013 118 0.016
negative regulation of phosphorus metabolic process GO:0010563 267 0.016
regulation of cellular response to stress GO:0080135 244 0.016
regulation of protein stability GO:0031647 87 0.016
negative regulation of chemotaxis GO:0050922 13 0.016
negative regulation of proteolysis GO:0045861 132 0.016
cellular response to oxidative stress GO:0034599 85 0.016
positive regulation of cellular component organization GO:0051130 376 0.015
regulation of cytokine secretion GO:0050707 57 0.015
negative regulation of transport GO:0051051 176 0.015
regulation of endopeptidase activity GO:0052548 170 0.015
carbohydrate metabolic process GO:0005975 207 0.015
b cell proliferation GO:0042100 22 0.015
oogenesis GO:0048477 2 0.015
regulation of gtpase activity GO:0043087 180 0.014
regulation of antigen processing and presentation of peptide antigen GO:0002583 4 0.014
regulation of protein maturation GO:1903317 150 0.014
ameboidal type cell migration GO:0001667 135 0.014
negative regulation of intracellular signal transduction GO:1902532 183 0.014
positive regulation of cell motility GO:2000147 177 0.014
regulation of vesicle mediated transport GO:0060627 130 0.014
determination of adult lifespan GO:0008340 2 0.014
response to dexamethasone GO:0071548 1 0.014
intracellular protein transport GO:0006886 270 0.014
regulation of protein processing GO:0070613 150 0.014
response to glucose GO:0009749 19 0.014
detection of stimulus GO:0051606 85 0.014
cellular response to dexamethasone stimulus GO:0071549 1 0.014
purine ribonucleoside catabolic process GO:0046130 398 0.014
regulation of protein serine threonine kinase activity GO:0071900 179 0.014
negative regulation of protein maturation GO:1903318 142 0.013
monocarboxylic acid metabolic process GO:0032787 185 0.013
apoptotic signaling pathway GO:0097190 268 0.013
tissue homeostasis GO:0001894 63 0.013
regulation of b cell proliferation GO:0030888 18 0.013
positive regulation of immune effector process GO:0002699 40 0.013
detection of chemical stimulus GO:0009593 55 0.013
small gtpase mediated signal transduction GO:0007264 78 0.013
mitotic cell cycle phase transition GO:0044772 162 0.013
purine ribonucleoside metabolic process GO:0046128 437 0.013
negative regulation of inflammatory response GO:0050728 22 0.013
growth GO:0040007 202 0.013
regulation of cytoskeleton organization GO:0051493 177 0.013
negative regulation of cell cycle GO:0045786 193 0.012
protein catabolic process GO:0030163 325 0.012
regulation of intracellular transport of viral material GO:1901252 2 0.012
negative regulation of cellular catabolic process GO:0031330 83 0.012
nervous system development GO:0007399 293 0.012
regulation of acute inflammatory response to antigenic stimulus GO:0002864 1 0.012
regulation of cell projection organization GO:0031344 107 0.012
cellular protein catabolic process GO:0044257 261 0.012
cell activation involved in immune response GO:0002263 30 0.012
protein folding GO:0006457 38 0.012
cellular response to glucocorticoid stimulus GO:0071385 4 0.012
adaptive immune response GO:0002250 49 0.012
regulation of transmembrane transport GO:0034762 139 0.011
purine containing compound catabolic process GO:0072523 411 0.011
organic acid biosynthetic process GO:0016053 97 0.011
mitotic cell cycle GO:0000278 326 0.011
regulation of t cell differentiation GO:0045580 19 0.011
negative regulation of phosphate metabolic process GO:0045936 267 0.011
regulation of peptide transport GO:0090087 62 0.011
cell growth GO:0016049 160 0.011
nucleoside phosphate catabolic process GO:1901292 412 0.011
positive regulation of programmed cell death GO:0043068 249 0.011
regulation of syncytium formation by plasma membrane fusion GO:0060142 2 0.011
vesicle mediated transport GO:0016192 371 0.011
negative regulation of protein processing GO:0010955 142 0.011
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 40 0.011
positive regulation of homeostatic process GO:0032846 47 0.011
regulation of intracellular protein transport GO:0033157 123 0.011
cellular response to nitrogen compound GO:1901699 144 0.011
sprouting angiogenesis GO:0002040 29 0.011
negative regulation of cellular component movement GO:0051271 106 0.011
positive regulation of b cell proliferation GO:0030890 12 0.011
small molecule biosynthetic process GO:0044283 157 0.011
organelle assembly GO:0070925 176 0.010
positive regulation of apoptotic signaling pathway GO:2001235 70 0.010
modification dependent protein catabolic process GO:0019941 209 0.010
cellular response to endogenous stimulus GO:0071495 336 0.010
transmission of nerve impulse GO:0019226 11 0.010
interferon gamma production GO:0032609 39 0.010
regulation of innate immune response GO:0045088 97 0.010
guanosine containing compound catabolic process GO:1901069 239 0.010
lymphocyte homeostasis GO:0002260 4 0.010
anatomical structure formation involved in morphogenesis GO:0048646 284 0.010
reactive oxygen species metabolic process GO:0072593 75 0.010
mitotic cell cycle process GO:1903047 286 0.010
small molecule catabolic process GO:0044282 92 0.010

HLA-DRB1 disease predictions

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 155 0.620
hypersensitivity reaction disease DOID:0060056 25 0.576
central nervous system disease DOID:331 186 0.118
nervous system disease DOID:863 431 0.118
brain disease DOID:936 73 0.014
Human
musculoskeletal system disease DOID:17 223 0.012
disease of metabolism DOID:0014667 295 0.012
disease of cellular proliferation DOID:14566 174 0.012
bone disease DOID:0080001 88 0.007
connective tissue disease DOID:65 109 0.007
neurodegenerative disease DOID:1289 102 0.007
bone inflammation disease DOID:3342 10 0.001
rheumatoid arthritis DOID:7148 8 0.001
arthritis DOID:848 8 0.001
demyelinating disease DOID:3213 4 0.001
multiple sclerosis DOID:2377 4 0.001
hypersensitivity reaction type iv disease DOID:2916 6 0.000
sarcoidosis DOID:11335 3 0.000