Homo sapiens

61 known processes

HLA-E

major histocompatibility complex, class I, E

(Aliases: QA1,EA2.1,HLA-6.2,EA1.2,MHC,DKFZp686P19218)

HLA-E biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
detection of chemical stimulus involved in sensory perception GO:0050907 33 1.000
Human
immune response inhibiting cell surface receptor signaling pathway GO:0002767 4 1.000
Human
antigen processing and presentation via mhc class ib GO:0002475 3 1.000
positive regulation of natural killer cell mediated immunity GO:0002717 12 1.000
detection of external biotic stimulus GO:0098581 19 1.000
Human
detection of chemical stimulus GO:0009593 55 1.000
Human
regulation of regulatory t cell differentiation GO:0045589 4 0.999
Human
positive regulation of t cell tolerance induction GO:0002666 2 0.999
Human
sensory perception of taste GO:0050909 36 0.999
Human
regulation of dendritic cell differentiation GO:2001198 3 0.998
Human
regulation of natural killer cell mediated cytotoxicity GO:0042269 16 0.998
positive regulation of regulatory t cell differentiation GO:0045591 3 0.998
Human
sensory perception of chemical stimulus GO:0007606 38 0.996
Human
sensory perception of bitter taste GO:0050913 28 0.991
Human
negative regulation of natural killer cell mediated cytotoxicity GO:0045953 5 0.974
antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway GO:0002484 3 0.958
Human
antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway tap independent GO:0002486 3 0.952
Human
dendritic cell differentiation GO:0097028 13 0.944
Human
tolerance induction GO:0002507 6 0.932
Human
immune response inhibiting signal transduction GO:0002765 4 0.929
Human
positive regulation of cytokine production GO:0001819 167 0.929
Human
iron ion import into cell GO:0097459 2 0.927
Human
detection of biotic stimulus GO:0009595 21 0.918
Human
antigen processing and presentation of peptide antigen via mhc class i GO:0002474 6 0.900
Human
negative regulation of cell proliferation GO:0008285 228 0.899
Human
antigen processing and presentation of peptide antigen via mhc class ib GO:0002428 2 0.895
regulation of leukocyte mediated immunity GO:0002703 38 0.886
positive regulation of lymphocyte differentiation GO:0045621 13 0.883
Human
response to external biotic stimulus GO:0043207 261 0.877
Human
negative regulation of t cell proliferation GO:0042130 8 0.872
Human
regulation of cell killing GO:0031341 22 0.870
detection of stimulus GO:0051606 85 0.861
Human
regulation of cytokine production GO:0001817 232 0.851
Human
response to other organism GO:0051707 261 0.847
Human
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 19 0.838
Human
positive regulation of immune response GO:0050778 159 0.833
antigen processing and presentation of endogenous antigen GO:0019883 7 0.828
negative regulation of lymphocyte mediated immunity GO:0002707 12 0.823
retina homeostasis GO:0001895 42 0.822
Human
regulation of t cell mediated cytotoxicity GO:0001914 8 0.821
Human
positive regulation of interleukin 12 production GO:0032735 8 0.819
Human
immune effector process GO:0002252 159 0.818
type i interferon signaling pathway GO:0060337 11 0.817
negative regulation of leukocyte mediated immunity GO:0002704 14 0.811
detection of chemical stimulus involved in sensory perception of taste GO:0050912 31 0.799
Human
natural killer cell mediated immunity GO:0002228 23 0.790
lymphocyte mediated immunity GO:0002449 48 0.786
negative regulation of leukocyte activation GO:0002695 26 0.785
Human
memory t cell activation GO:0035709 1 0.780
Human
response to bacterium GO:0009617 144 0.779
Human
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.779
regulation of adaptive immune response GO:0002819 33 0.768
Human
immune response GO:0006955 307 0.760
regulation of t cell proliferation GO:0042129 42 0.747
Human
regulation of natural killer cell mediated immunity GO:0002715 16 0.747
defense response GO:0006952 315 0.746
leukocyte activation GO:0045321 164 0.740
Human
negative regulation of leukocyte differentiation GO:1902106 24 0.726
Human
cytokine production GO:0001816 247 0.725
Human
innate immune response GO:0045087 178 0.724
regulation of innate immune response GO:0045088 97 0.718
positive regulation of innate immune response GO:0045089 79 0.714
inorganic cation import into cell GO:0098659 2 0.703
Human
natural killer cell mediated cytotoxicity GO:0042267 23 0.701
positive regulation of tolerance induction GO:0002645 2 0.694
Human
response to biotic stimulus GO:0009607 276 0.689
Human
regulation of t cell activation GO:0050863 77 0.685
Human
detection of bacterium GO:0016045 13 0.683
Human
negative regulation of immune response GO:0050777 40 0.677
regulation of interleukin 12 production GO:0032655 15 0.675
Human
multicellular organismal homeostasis GO:0048871 67 0.670
Human
detection of other organism GO:0098543 13 0.668
Human
positive regulation of immune system process GO:0002684 283 0.662
regulation of immune response GO:0050776 201 0.660
positive regulation of leukocyte activation GO:0002696 80 0.657
Human
positive regulation of t cell mediated immunity GO:0002711 12 0.657
Human
transition metal ion transport GO:0000041 23 0.648
Human
negative regulation of defense response GO:0031348 47 0.641
import into cell GO:0098657 2 0.636
Human
antigen processing and presentation of endogenous peptide antigen via mhc class i GO:0019885 5 0.636
Human
regulation of leukocyte activation GO:0002694 115 0.627
Human
cell killing GO:0001906 34 0.625
regulation of t cell tolerance induction GO:0002664 4 0.620
Human
negative regulation of dendritic cell differentiation GO:2001199 2 0.600
Human
negative regulation of cell killing GO:0031342 5 0.596
positive regulation of interferon gamma production GO:0032729 26 0.592
Human
positive regulation of leukocyte differentiation GO:1902107 37 0.587
Human
positive regulation of leukocyte mediated immunity GO:0002705 24 0.580
positive regulation of adaptive immune response GO:0002821 21 0.568
Human
t cell tolerance induction GO:0002517 4 0.567
Human
anatomical structure homeostasis GO:0060249 100 0.556
Human
positive regulation of t cell activation GO:0050870 54 0.553
Human
regulation of leukocyte proliferation GO:0070663 67 0.539
Human
positive regulation of cell differentiation GO:0045597 211 0.537
Human
tissue homeostasis GO:0001894 63 0.521
Human
t cell activation GO:0042110 99 0.506
Human
protection from natural killer cell mediated cytotoxicity GO:0042270 3 0.504
antigen processing and presentation of peptide antigen GO:0048002 18 0.489
immune response regulating signaling pathway GO:0002764 97 0.489
Human
positive regulation of leukocyte mediated cytotoxicity GO:0001912 16 0.485
Human
positive regulation of defense response GO:0031349 87 0.483
regulation of mononuclear cell proliferation GO:0032944 65 0.482
Human
negative regulation of cell differentiation GO:0045596 171 0.481
Human
negative regulation of developmental process GO:0051093 247 0.480
Human
t cell differentiation GO:0030217 29 0.479
Human
regulation of lymphocyte mediated immunity GO:0002706 33 0.478
regulation of lymphocyte proliferation GO:0050670 64 0.463
Human
metal ion transport GO:0030001 272 0.462
Human
iron ion transport GO:0006826 12 0.457
Human
lymphocyte proliferation GO:0046651 70 0.454
Human
leukocyte proliferation GO:0070661 74 0.446
Human
regulation of leukocyte mediated cytotoxicity GO:0001910 19 0.435
mononuclear cell proliferation GO:0032943 71 0.434
Human
positive regulation of memory t cell activation GO:2000568 1 0.433
Human
negative regulation of leukocyte mediated cytotoxicity GO:0001911 5 0.432
cell activation GO:0001775 213 0.428
Human
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 29 0.420
Human
biological adhesion GO:0022610 331 0.415
Human
regulation of defense response GO:0031347 154 0.403
antigen processing and presentation GO:0019882 33 0.393
interleukin 12 production GO:0032615 15 0.393
Human
leukocyte mediated cytotoxicity GO:0001909 27 0.389
positive regulation of developmental process GO:0051094 314 0.386
Human
cell adhesion GO:0007155 325 0.385
Human
regulation of lymphocyte activation GO:0051249 103 0.377
Human
adaptive immune response GO:0002250 49 0.375
Human
negative regulation of multicellular organismal process GO:0051241 317 0.371
Human
negative regulation of immune effector process GO:0002698 38 0.363
negative regulation of natural killer cell mediated immunity GO:0002716 5 0.361
regulation of tolerance induction GO:0002643 4 0.349
Human
regulation of interferon gamma production GO:0032649 36 0.348
Human
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 40 0.342
Human
leukocyte differentiation GO:0002521 98 0.329
Human
regulation of t cell mediated immunity GO:0002709 18 0.327
Human
positive regulation of cell killing GO:0031343 19 0.327
Human
negative regulation of immune system process GO:0002683 136 0.326
positive regulation of cell activation GO:0050867 81 0.320
Human
hemopoiesis GO:0030097 180 0.316
Human
regulation of cell differentiation GO:0045595 393 0.307
Human
immune system development GO:0002520 195 0.306
Human
response to interferon gamma GO:0034341 39 0.304
detection of stimulus involved in sensory perception GO:0050906 43 0.301
Human
regulation of cell activation GO:0050865 125 0.300
Human
regulation of t cell differentiation GO:0045580 19 0.296
Human
antigen processing and presentation of endogenous peptide antigen via mhc class ib GO:0002476 2 0.291
cation transport GO:0006812 331 0.284
Human
interferon gamma production GO:0032609 39 0.272
Human
regulation of leukocyte differentiation GO:1902105 61 0.257
Human
immune response regulating cell surface receptor signaling pathway GO:0002768 51 0.252
Human
neurological system process GO:0050877 163 0.240
Human
regulation of lymphocyte differentiation GO:0045619 22 0.223
Human
antigen processing and presentation of endogenous peptide antigen GO:0002483 6 0.223
positive regulation of t cell differentiation GO:0045582 11 0.215
Human
lymphocyte activation GO:0046649 133 0.212
Human
sensory perception GO:0007600 103 0.211
Human
positive regulation of t cell mediated cytotoxicity GO:0001916 7 0.202
Human
negative regulation of cell activation GO:0050866 33 0.202
Human
positive regulation of lymphocyte activation GO:0051251 73 0.197
Human
leukocyte mediated immunity GO:0002443 59 0.196
negative regulation of leukocyte proliferation GO:0070664 16 0.176
Human
inorganic ion import into cell GO:0099587 2 0.176
Human
regulation of immune effector process GO:0002697 91 0.176
hematopoietic or lymphoid organ development GO:0048534 186 0.176
Human
t cell mediated immunity GO:0002456 25 0.166
Human
negative regulation of mononuclear cell proliferation GO:0032945 15 0.156
Human
lymphocyte differentiation GO:0030098 35 0.154
Human
positive regulation of immune effector process GO:0002699 40 0.150
negative regulation of lymphocyte proliferation GO:0050672 15 0.146
Human
system process GO:0003008 349 0.138
Human
viral life cycle GO:0019058 132 0.138
viral process GO:0016032 146 0.135
purine ribonucleoside metabolic process GO:0046128 437 0.134
t cell mediated cytotoxicity GO:0001913 9 0.131
Human
positive regulation of lymphocyte mediated immunity GO:0002708 23 0.123
negative regulation of t cell activation GO:0050868 18 0.109
Human
negative regulation of innate immune response GO:0045824 18 0.095
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.092
regulation of cellular amino acid metabolic process GO:0006521 6 0.083
response to virus GO:0009615 126 0.074
t cell proliferation GO:0042098 45 0.071
Human
response to type i interferon GO:0034340 14 0.070
negative regulation of lymphocyte activation GO:0051250 24 0.065
Human
regulation of memory t cell activation GO:2000567 1 0.064
Human
post embryonic development GO:0009791 2 0.062
cytoplasmic transport GO:0016482 379 0.060
negative regulation of cellular protein metabolic process GO:0032269 353 0.059
interleukin 6 production GO:0032635 37 0.056
interaction with host GO:0051701 42 0.055
detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 28 0.054
Human
interleukin 13 biosynthetic process GO:0042231 1 0.050
entry into host GO:0044409 25 0.047
defense response to other organism GO:0098542 129 0.046
regulation of apoptotic signaling pathway GO:2001233 175 0.046
cellular response to cytokine stimulus GO:0071345 181 0.045
regulation of viral transcription GO:0046782 34 0.045
entry into host cell GO:0030260 25 0.045
cytokine mediated signaling pathway GO:0019221 109 0.041
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.041
multi organism metabolic process GO:0044033 41 0.041
positive regulation of interleukin 4 biosynthetic process GO:0045404 1 0.041
regulation of cell migration GO:0030334 289 0.037
defense response to virus GO:0051607 71 0.037
negative regulation of viral entry into host cell GO:0046597 12 0.036
viral transcription GO:0019083 35 0.034
cell projection organization GO:0030030 252 0.034
regulatory t cell differentiation GO:0045066 5 0.033
Human
cellular response to oxidative stress GO:0034599 85 0.032
regulation of angiogenesis GO:0045765 92 0.032
purine containing compound catabolic process GO:0072523 411 0.031
negative regulation of multi organism process GO:0043901 92 0.031
mapk cascade GO:0000165 288 0.031
intracellular protein transport GO:0006886 270 0.030
cellular response to interferon gamma GO:0071346 24 0.029
response to organonitrogen compound GO:0010243 156 0.029
ribonucleotide catabolic process GO:0009261 405 0.028
regulation of cell cycle GO:0051726 393 0.027
t cell differentiation in thymus GO:0033077 4 0.027
secretion by cell GO:0032940 226 0.027
viral gene expression GO:0019080 35 0.026
positive regulation of interleukin 13 production GO:0032736 4 0.026
interspecies interaction between organisms GO:0044419 156 0.025
regulation of viral genome replication GO:0045069 48 0.025
response to cytokine GO:0034097 232 0.024
cellular response to type i interferon GO:0071357 12 0.024
ossification GO:0001503 121 0.024
amine metabolic process GO:0009308 44 0.023
multi organism cellular process GO:0044764 156 0.022
cellular response to dna damage stimulus GO:0006974 379 0.021
nucleoside catabolic process GO:0009164 408 0.021
protein maturation GO:0051604 233 0.021
osteoblast differentiation GO:0001649 92 0.020
response to oxygen containing compound GO:1901700 369 0.020
negative regulation of viral process GO:0048525 66 0.020
negative regulation of catalytic activity GO:0043086 335 0.019
ribonucleoside triphosphate metabolic process GO:0009199 412 0.019
regulation of secretion GO:0051046 194 0.019
multicellular organismal aging GO:0010259 3 0.019
regulation of viral process GO:0050792 103 0.019
blood vessel morphogenesis GO:0048514 162 0.019
purine nucleoside monophosphate metabolic process GO:0009126 186 0.019
cardiovascular system development GO:0072358 262 0.019
nucleoside phosphate catabolic process GO:1901292 412 0.018
regulation of protein localization GO:0032880 296 0.018
regulation of locomotion GO:0040012 329 0.018
immune response activating signal transduction GO:0002757 90 0.018
dna catabolic process exonucleolytic GO:0000738 17 0.018
regulation of cellular component movement GO:0051270 334 0.018
negative regulation of cell motility GO:2000146 104 0.018
determination of adult lifespan GO:0008340 2 0.018
negative regulation of intracellular signal transduction GO:1902532 183 0.018
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.018
response to interferon beta GO:0035456 11 0.018
negative regulation of cell migration GO:0030336 102 0.017
secretion GO:0046903 254 0.017
maintenance of location in cell GO:0051651 62 0.017
negative regulation of viral transcription GO:0032897 23 0.017
cellular macromolecule catabolic process GO:0044265 380 0.016
positive regulation of cellular catabolic process GO:0031331 284 0.016
regulation of cellular ketone metabolic process GO:0010565 50 0.016
epithelial cell proliferation GO:0050673 128 0.016
purine nucleoside catabolic process GO:0006152 398 0.016
rna catabolic process GO:0006401 71 0.016
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.016
regulation of osteoblast differentiation GO:0045667 38 0.016
entry into other organism involved in symbiotic interaction GO:0051828 25 0.016
regulation of multi organism process GO:0043900 157 0.015
positive regulation of ossification GO:0045778 32 0.015
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.015
i kappab kinase nf kappab signaling GO:0007249 166 0.015
signal transduction by phosphorylation GO:0023014 297 0.014
ribonucleoside triphosphate catabolic process GO:0009203 391 0.014
negative regulation of protein metabolic process GO:0051248 391 0.014
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.014
regulation of establishment of protein localization GO:0070201 242 0.014
negative regulation of transport GO:0051051 176 0.014
viral entry into host cell GO:0046718 24 0.014
interleukin 4 biosynthetic process GO:0042097 2 0.013
negative regulation of cell death GO:0060548 345 0.013
negative regulation of protein activation cascade GO:2000258 7 0.013
regulation of cell motility GO:2000145 299 0.013
blastoderm segmentation GO:0007350 2 0.013
purine ribonucleotide catabolic process GO:0009154 404 0.013
chemical homeostasis GO:0048878 306 0.013
negative regulation of protein processing GO:0010955 142 0.012
cellular amine metabolic process GO:0044106 41 0.012
regulation of vasculature development GO:1901342 97 0.012
negative regulation of phosphorus metabolic process GO:0010563 267 0.012
regulation of purine nucleotide metabolic process GO:1900542 264 0.012
negative regulation of locomotion GO:0040013 118 0.012
positive regulation of programmed cell death GO:0043068 249 0.012
regulation of transferase activity GO:0051338 355 0.012
nucleotide catabolic process GO:0009166 408 0.012
movement in host environment GO:0052126 25 0.012
negative regulation of antigen processing and presentation GO:0002578 5 0.012
negative regulation of cellular component movement GO:0051271 106 0.012
intracellular transport of viral protein in host cell GO:0019060 4 0.012
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.012
modification dependent protein catabolic process GO:0019941 209 0.012
purine nucleotide catabolic process GO:0006195 405 0.011
negative regulation of cell cycle GO:0045786 193 0.011
regulation of protein maturation GO:1903317 150 0.011
neuron development GO:0048666 113 0.011
positive regulation of cell death GO:0010942 263 0.011
cellular response to oxygen containing compound GO:1901701 276 0.011
positive regulation of cellular amine metabolic process GO:0033240 7 0.011
circulatory system development GO:0072359 262 0.011
positive regulation of apoptotic process GO:0043065 246 0.011
apoptotic signaling pathway GO:0097190 268 0.011
negative regulation of phosphorylation GO:0042326 174 0.011
regulation of viral entry into host cell GO:0046596 17 0.011
protein localization to organelle GO:0033365 280 0.011
negative regulation of protein modification process GO:0031400 200 0.010
interleukin 13 production GO:0032616 7 0.010
cellular amino acid metabolic process GO:0006520 116 0.010
cellular protein catabolic process GO:0044257 261 0.010
regulation of actin filament based process GO:0032970 141 0.010
response to mechanical stimulus GO:0009612 51 0.010
positive regulation of hydrolase activity GO:0051345 331 0.010
prostate gland development GO:0030850 3 0.010
regulation of cellular amine metabolic process GO:0033238 11 0.010
response to peptidoglycan GO:0032494 3 0.010

HLA-E disease predictions

Disease DO term ID Size Probability Func Analog Org
disease by infectious agent DOID:0050117 34 0.320
Human
viral infectious disease DOID:934 13 0.320
Human
acquired immunodeficiency syndrome DOID:635 13 0.303
Human
human immunodeficiency virus infectious disease DOID:526 13 0.303
Human
musculoskeletal system disease DOID:17 223 0.200
immune system disease DOID:2914 155 0.031
primary immunodeficiency disease DOID:612 36 0.029
severe combined immunodeficiency DOID:627 10 0.029
combined t cell and b cell immunodeficiency DOID:628 12 0.029
connective tissue disease DOID:65 109 0.013
skin disease DOID:37 33 0.011
Human
integumentary system disease DOID:16 43 0.011
Human