Homo sapiens

28 known processes

HMGCL

3-hydroxymethyl-3-methylglutaryl-CoA lyase

(Aliases: HL)

HMGCL biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular amino acid metabolic process GO:0006520 116 0.618
organic acid catabolic process GO:0016054 71 0.557
carboxylic acid catabolic process GO:0046395 71 0.492
negative regulation of hepatocyte growth factor receptor signaling pathway GO:1902203 1 0.472
negative regulation of cellular response to hepatocyte growth factor stimulus GO:2001113 1 0.466
regulation of cellular response to hepatocyte growth factor stimulus GO:2001112 1 0.337
positive regulation of vascular endothelial growth factor signaling pathway GO:1900748 3 0.261
small molecule catabolic process GO:0044282 92 0.241
fatty acid metabolic process GO:0006631 115 0.229
lipid metabolic process GO:0006629 381 0.210
oxidation reduction process GO:0055114 396 0.206
cellular lipid metabolic process GO:0044255 303 0.199
proteoglycan catabolic process GO:0030167 3 0.174
lipid modification GO:0030258 84 0.145
cellular ketone metabolic process GO:0042180 80 0.119
monocarboxylic acid catabolic process GO:0072329 37 0.110
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.096
regulation of cellular ketone metabolic process GO:0010565 50 0.088
cellular macromolecule catabolic process GO:0044265 380 0.086
lipid catabolic process GO:0016042 84 0.085
fatty acid catabolic process GO:0009062 29 0.083
amine metabolic process GO:0009308 44 0.077
cellular protein catabolic process GO:0044257 261 0.076
enzyme linked receptor protein signaling pathway GO:0007167 303 0.075
cellular amino acid catabolic process GO:0009063 31 0.072
cofactor metabolic process GO:0051186 87 0.072
Rat
regulation of cellular amino acid metabolic process GO:0006521 6 0.071
branched chain amino acid metabolic process GO:0009081 4 0.069
peptide metabolic process GO:0006518 51 0.069
branched chain amino acid catabolic process GO:0009083 4 0.068
monocarboxylic acid metabolic process GO:0032787 185 0.065
neuroblast proliferation GO:0007405 4 0.063
cellular lipid catabolic process GO:0044242 65 0.059
single organism carbohydrate metabolic process GO:0044723 193 0.059
cellular amine metabolic process GO:0044106 41 0.058
regulation of cellular amine metabolic process GO:0033238 11 0.058
lipid biosynthetic process GO:0008610 177 0.054
glycoprotein metabolic process GO:0009100 110 0.053
cellular response to growth factor stimulus GO:0071363 197 0.052
negative regulation of multicellular organismal process GO:0051241 317 0.051
cytoplasmic transport GO:0016482 379 0.050
short chain fatty acid metabolic process GO:0046459 2 0.049
cellular response to endogenous stimulus GO:0071495 336 0.049
modification dependent macromolecule catabolic process GO:0043632 212 0.048
negative regulation of platelet aggregation GO:0090331 3 0.048
protein maturation GO:0051604 233 0.047
regulation of vascular endothelial growth factor signaling pathway GO:1900746 6 0.047
heart formation GO:0060914 2 0.047
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.046
fatty acid oxidation GO:0019395 31 0.045
negative regulation of developmental process GO:0051093 247 0.044
regulation of neural precursor cell proliferation GO:2000177 4 0.043
modification dependent protein catabolic process GO:0019941 209 0.042
post embryonic development GO:0009791 2 0.042
organic acid biosynthetic process GO:0016053 97 0.042
alcohol metabolic process GO:0006066 114 0.042
positive regulation of cellular amine metabolic process GO:0033240 7 0.041
pancreatic a cell differentiation GO:0003310 1 0.041
ubiquitin dependent protein catabolic process GO:0006511 206 0.041
negative regulation of hemostasis GO:1900047 22 0.040
small molecule biosynthetic process GO:0044283 157 0.039
protein processing GO:0016485 226 0.039
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.038
regulation of defense response GO:0031347 154 0.038
regulation of platelet aggregation GO:0090330 4 0.038
response to growth factor GO:0070848 205 0.038
cellular amide metabolic process GO:0043603 69 0.037
cellular modified amino acid metabolic process GO:0006575 64 0.036
salivary gland morphogenesis GO:0007435 4 0.035
carbohydrate metabolic process GO:0005975 207 0.034
negative regulation of cell differentiation GO:0045596 171 0.034
glutathione metabolic process GO:0006749 20 0.034
regulation of cell activation GO:0050865 125 0.034
metanephric nephron tubule morphogenesis GO:0072282 1 0.033
organic hydroxy compound metabolic process GO:1901615 147 0.033
negative regulation of homotypic cell cell adhesion GO:0034111 3 0.032
regulation of cell differentiation GO:0045595 393 0.032
sulfur compound metabolic process GO:0006790 101 0.031
Rat
lipid oxidation GO:0034440 33 0.031
regulation of neuroblast proliferation GO:1902692 3 0.030
organonitrogen compound biosynthetic process GO:1901566 200 0.030
multicellular organismal aging GO:0010259 3 0.030
positive regulation of transport GO:0051050 336 0.030
defense response GO:0006952 315 0.029
monocarboxylic acid biosynthetic process GO:0072330 67 0.029
single organism cellular localization GO:1902580 332 0.029
coenzyme metabolic process GO:0006732 65 0.029
Rat
female gamete generation GO:0007292 2 0.029
hindbrain development GO:0030902 3 0.028
intracellular protein transport GO:0006886 270 0.028
response to cytokine GO:0034097 232 0.027
organophosphate biosynthetic process GO:0090407 163 0.027
regulation of cellular response to growth factor stimulus GO:0090287 76 0.026
nerve development GO:0021675 4 0.026
epithelium development GO:0060429 227 0.026
protein oligomerization GO:0051259 173 0.026
thymus development GO:0048538 3 0.026
proteoglycan metabolic process GO:0006029 29 0.026
negative regulation of protein metabolic process GO:0051248 391 0.026
negative regulation of cell proliferation GO:0008285 228 0.026
protein ubiquitination GO:0016567 314 0.025
oogenesis GO:0048477 2 0.025
cytokine production GO:0001816 247 0.025
cranial nerve development GO:0021545 4 0.024
positive regulation of neural precursor cell proliferation GO:2000179 2 0.024
cell activation GO:0001775 213 0.024
astrocyte differentiation GO:0048708 4 0.023
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.023
adult locomotory behavior GO:0008344 1 0.023
cofactor biosynthetic process GO:0051188 31 0.023
skeletal system development GO:0001501 79 0.023
negative regulation of cellular protein metabolic process GO:0032269 353 0.023
protein catabolic process GO:0030163 325 0.023
locomotory behavior GO:0007626 1 0.022
s shaped body morphogenesis GO:0072050 4 0.022
calcium ion transport GO:0006816 147 0.022
sex determination GO:0007530 3 0.022
connective tissue development GO:0061448 39 0.021
organ formation GO:0048645 3 0.021
pituitary gland development GO:0021983 2 0.021
neuroendocrine cell differentiation GO:0061101 2 0.021
carboxylic acid biosynthetic process GO:0046394 97 0.021
neuron fate commitment GO:0048663 2 0.021
neural crest cell development GO:0014032 3 0.021
proteasomal protein catabolic process GO:0010498 176 0.021
response to decreased oxygen levels GO:0036293 96 0.021
fatty acid biosynthetic process GO:0006633 46 0.021
mitotic cell cycle process GO:1903047 286 0.020
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 0.020
regulation of anatomical structure morphogenesis GO:0022603 286 0.020
neural tube patterning GO:0021532 2 0.020
cellular response to dna damage stimulus GO:0006974 379 0.020
carbohydrate derivative biosynthetic process GO:1901137 207 0.020
determination of adult lifespan GO:0008340 2 0.020
membrane organization GO:0061024 292 0.020
cellular response to cytokine stimulus GO:0071345 181 0.019
nucleoside phosphate biosynthetic process GO:1901293 109 0.019
negative regulation of reactive oxygen species metabolic process GO:2000378 11 0.019
positive regulation of phosphorylation GO:0042327 394 0.019
negative regulation of cellular amine metabolic process GO:0033239 3 0.019
cell adhesion GO:0007155 325 0.019
cellular response to tumor necrosis factor GO:0071356 63 0.019
positive regulation of immune system process GO:0002684 283 0.018
regulation of cell cycle GO:0051726 393 0.018
regulation of organ formation GO:0003156 4 0.018
secretion GO:0046903 254 0.018
blastoderm segmentation GO:0007350 2 0.018
positive regulation of gliogenesis GO:0014015 4 0.018
negative regulation of glial cell proliferation GO:0060253 2 0.018
biological adhesion GO:0022610 331 0.018
negative regulation of catalytic activity GO:0043086 335 0.018
negative regulation of cell development GO:0010721 48 0.018
dephosphorylation GO:0016311 209 0.017
negative regulation of protein maturation GO:1903318 142 0.017
inflammatory response GO:0006954 79 0.017
ventricular septum morphogenesis GO:0060412 3 0.017
segmentation GO:0035282 4 0.017
apoptotic signaling pathway GO:0097190 268 0.017
alpha amino acid catabolic process GO:1901606 26 0.017
rostrocaudal neural tube patterning GO:0021903 1 0.017
protein localization to organelle GO:0033365 280 0.017
response to hypoxia GO:0001666 96 0.017
negative regulation of cellular component organization GO:0051129 235 0.017
regulation of response to external stimulus GO:0032101 222 0.017
immune response GO:0006955 307 0.017
regulation of protein transport GO:0051223 213 0.016
protein modification by small protein conjugation GO:0032446 342 0.016
coagulation GO:0050817 78 0.016
metal ion transport GO:0030001 272 0.016
regulation of reactive oxygen species metabolic process GO:2000377 41 0.016
very long chain fatty acid metabolic process GO:0000038 19 0.016
epithelial cell differentiation GO:0030855 141 0.016
peripheral nervous system development GO:0007422 2 0.016
negative regulation of phosphate metabolic process GO:0045936 267 0.016
pharyngeal system development GO:0060037 2 0.016
embryonic placenta development GO:0001892 1 0.016
negative regulation of intracellular signal transduction GO:1902532 183 0.016
hepatocyte growth factor receptor signaling pathway GO:0048012 8 0.016
regulation of glial cell differentiation GO:0045685 3 0.016
negative regulation of response to wounding GO:1903035 47 0.016
negative regulation of response to external stimulus GO:0032102 83 0.016
negative regulation of phosphorus metabolic process GO:0010563 267 0.015
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.015
regulation of protein localization GO:0032880 296 0.015
positive regulation of secretion by cell GO:1903532 108 0.015
response to external biotic stimulus GO:0043207 261 0.015
positive regulation of synaptic transmission GO:0050806 4 0.015
nucleocytoplasmic transport GO:0006913 176 0.015
single organism cell adhesion GO:0098602 179 0.015
fatty acid beta oxidation GO:0006635 22 0.015
regulation of secretion GO:0051046 194 0.015
response to wounding GO:0009611 168 0.015
positive regulation of neuroblast proliferation GO:0002052 2 0.015
positive regulation of secretion GO:0051047 116 0.015
regulation of proteolysis GO:0030162 293 0.015
cellular response to oxygen containing compound GO:1901701 276 0.015
protein acylation GO:0043543 138 0.014
establishment of protein localization to organelle GO:0072594 172 0.014
fatty acid beta oxidation using acyl coa dehydrogenase GO:0033539 3 0.014
epithelial cell fate commitment GO:0072148 3 0.014
secretion by cell GO:0032940 226 0.014
cell fate determination GO:0001709 3 0.014
regulation of mitotic cell cycle GO:0007346 189 0.014
dna repair GO:0006281 198 0.014
regulation of cellular component biogenesis GO:0044087 281 0.014
regulation of cell cycle process GO:0010564 266 0.014
negative regulation of immune system process GO:0002683 136 0.014
protein targeting GO:0006605 187 0.014
protein acetylation GO:0006473 116 0.014
multi organism cellular process GO:0044764 156 0.014
endothelium development GO:0003158 33 0.014
peptidyl lysine modification GO:0018205 144 0.014
store operated calcium entry GO:0002115 3 0.014
negative regulation of cell adhesion GO:0007162 64 0.014
response to tumor necrosis factor GO:0034612 76 0.014
regulation of lipid metabolic process GO:0019216 96 0.014
sensory perception of pain GO:0019233 4 0.014
peptide catabolic process GO:0043171 10 0.013
mitotic cell cycle GO:0000278 326 0.013
memory GO:0007613 3 0.013
regulation of protein maturation GO:1903317 150 0.013
interspecies interaction between organisms GO:0044419 156 0.013
histone modification GO:0016570 251 0.013
divalent inorganic cation transport GO:0072511 158 0.013
regulation of multi organism process GO:0043900 157 0.013
spermatid differentiation GO:0048515 4 0.013
regulation of hemostasis GO:1900046 42 0.013
reactive oxygen species metabolic process GO:0072593 75 0.013
regulation of cholesterol metabolic process GO:0090181 4 0.013
regulation of cellular response to stress GO:0080135 244 0.013
regulation of mitosis GO:0007088 63 0.013
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090100 41 0.013
negative regulation of glial cell differentiation GO:0045686 1 0.013
hemopoiesis GO:0030097 180 0.013
regulation of blood coagulation GO:0030193 42 0.013
immune system development GO:0002520 195 0.013
steroid metabolic process GO:0008202 94 0.013
cell morphogenesis GO:0000902 296 0.013
response to abiotic stimulus GO:0009628 336 0.013
negative regulation of cell death GO:0060548 345 0.013
cellular response to hepatocyte growth factor stimulus GO:0035729 6 0.013
cell projection organization GO:0030030 252 0.013
negative regulation of nervous system development GO:0051961 28 0.013
negative regulation of protein processing GO:0010955 142 0.013
regulation of response to wounding GO:1903034 101 0.013
hair cell differentiation GO:0035315 2 0.013
spermatid development GO:0007286 4 0.012
nuclear import GO:0051170 106 0.012
negative regulation of wound healing GO:0061045 25 0.012
hexose metabolic process GO:0019318 55 0.012
coenzyme a metabolic process GO:0015936 6 0.012
innate immune response GO:0045087 178 0.012
oocyte development GO:0048599 1 0.012
negative regulation of protein modification process GO:0031400 200 0.012
multicellular organismal metabolic process GO:0044236 34 0.012
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.012
regulation of glial cell proliferation GO:0060251 4 0.012
protein targeting to nucleus GO:0044744 104 0.012
ribonucleoside bisphosphate metabolic process GO:0033875 7 0.012
hematopoietic or lymphoid organ development GO:0048534 186 0.012
regulation of endothelial tube morphogenesis GO:1901509 1 0.012
cell matrix adhesion GO:0007160 85 0.012
purine containing compound catabolic process GO:0072523 411 0.012
metanephric nephron epithelium development GO:0072243 4 0.012
multi organism membrane organization GO:0044803 12 0.012
regulation of cell adhesion GO:0030155 166 0.012
positive regulation of cell differentiation GO:0045597 211 0.012
negative regulation of cell cycle GO:0045786 193 0.012
positive regulation of developmental process GO:0051094 314 0.012
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.012
regulation of calcium ion transport GO:0051924 79 0.012
response to other organism GO:0051707 261 0.012
glycosylation GO:0070085 71 0.012
protein homooligomerization GO:0051260 100 0.012
nuclear transport GO:0051169 179 0.012
alpha amino acid metabolic process GO:1901605 72 0.012
reactive nitrogen species metabolic process GO:2001057 3 0.012
coenzyme biosynthetic process GO:0009108 24 0.011
regulation of protein processing GO:0070613 150 0.011
regulation of cellular response to vascular endothelial growth factor stimulus GO:1902547 7 0.011
compound eye development GO:0048749 1 0.011
hemostasis GO:0007599 76 0.011
nitrogen compound transport GO:0071705 191 0.011
negative regulation of cellular catabolic process GO:0031330 83 0.011
cell cell signaling GO:0007267 155 0.011
peptidyl tyrosine phosphorylation GO:0018108 170 0.011
positive regulation of cellular component organization GO:0051130 376 0.011
regulation of inflammatory response GO:0050727 46 0.011
regulation of viral process GO:0050792 103 0.011
regulation of cell cell adhesion GO:0022407 57 0.011
regulation of secretion by cell GO:1903530 177 0.011
regulation of wound healing GO:0061041 56 0.011
negative regulation of blood coagulation GO:0030195 22 0.011
regulation of cell development GO:0060284 161 0.011
response to oxygen containing compound GO:1901700 369 0.011
Rat
negative regulation of cell activation GO:0050866 33 0.011
monosaccharide metabolic process GO:0005996 74 0.011
regulation of cytokine production GO:0001817 232 0.011
cellular carbohydrate metabolic process GO:0044262 84 0.011
maintenance of location GO:0051235 112 0.011
organelle fission GO:0048285 149 0.011
vascular endothelial growth factor production GO:0010573 15 0.011
reactive oxygen species biosynthetic process GO:1903409 4 0.011
negative regulation of phosphorylation GO:0042326 174 0.011
positive regulation of programmed cell death GO:0043068 249 0.011
response to bacterium GO:0009617 144 0.011
cellular chemical homeostasis GO:0055082 180 0.011
negative regulation of stem cell proliferation GO:2000647 3 0.011
positive regulation of apoptotic process GO:0043065 246 0.010
regulation of establishment of protein localization GO:0070201 242 0.010
protein localization to nucleus GO:0034504 136 0.010
cellular response to interleukin 1 GO:0071347 35 0.010
ras protein signal transduction GO:0007265 73 0.010
neuromuscular junction development GO:0007528 3 0.010
positive regulation of protein phosphorylation GO:0001934 313 0.010
cell part morphogenesis GO:0032990 137 0.010
positive regulation of cell death GO:0010942 263 0.010
negative regulation of programmed cell death GO:0043069 321 0.010
positive regulation of leukocyte activation GO:0002696 80 0.010
meiosis i GO:0007127 4 0.010
golgi vesicle transport GO:0048193 80 0.010
positive regulation of organelle organization GO:0010638 195 0.010
protein tetramerization GO:0051262 47 0.010
divalent metal ion transport GO:0070838 152 0.010
endosome transport via multivesicular body sorting pathway GO:0032509 3 0.010
viral life cycle GO:0019058 132 0.010
chemical homeostasis GO:0048878 306 0.010
regulation of body fluid levels GO:0050878 99 0.010
response to axon injury GO:0048678 1 0.010
cell substrate adhesion GO:0031589 132 0.010
cellular response to nutrient levels GO:0031669 69 0.010

HMGCL disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.243
inherited metabolic disorder DOID:655 242 0.243
amino acid metabolic disorder DOID:9252 50 0.056
carbohydrate metabolic disorder DOID:2978 55 0.027
cancer DOID:162 167 0.022
disease of cellular proliferation DOID:14566 174 0.022
organ system cancer DOID:0050686 164 0.022
central nervous system disease DOID:331 186 0.019
nervous system disease DOID:863 431 0.019
sensory system disease DOID:0050155 203 0.017
eye and adnexa disease DOID:1492 150 0.017
eye disease DOID:5614 149 0.017
neurodegenerative disease DOID:1289 102 0.014
musculoskeletal system disease DOID:17 223 0.013
cardiovascular system disease DOID:1287 106 0.011
urinary system disease DOID:18 40 0.011
myopathy DOID:423 104 0.011
muscular disease DOID:0080000 114 0.011
muscle tissue disease DOID:66 113 0.011
connective tissue disease DOID:65 109 0.011
organic acidemia DOID:0060159 14 0.011
retinal disease DOID:5679 118 0.010