Homo sapiens

65 known processes

HSD17B4

hydroxysteroid (17-beta) dehydrogenase 4

(Aliases: DBP,MFE-2,MPF-2,SDR8C1)

HSD17B4 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
oxidation reduction process GO:0055114 396 0.780
lipid modification GO:0030258 84 0.680
organic acid catabolic process GO:0016054 71 0.673
lipid oxidation GO:0034440 33 0.625
multicellular organismal aging GO:0010259 3 0.605
Worm
steroid metabolic process GO:0008202 94 0.591
determination of adult lifespan GO:0008340 2 0.545
Worm
cellular lipid metabolic process GO:0044255 303 0.538
monocarboxylic acid metabolic process GO:0032787 185 0.498
peroxisome organization GO:0007031 28 0.377
organic hydroxy compound metabolic process GO:1901615 147 0.336
monocarboxylic acid catabolic process GO:0072329 37 0.287
alcohol metabolic process GO:0006066 114 0.284
lipid metabolic process GO:0006629 381 0.273
protein homooligomerization GO:0051260 100 0.226
carboxylic acid catabolic process GO:0046395 71 0.154
cellular amino acid metabolic process GO:0006520 116 0.140
small molecule catabolic process GO:0044282 92 0.135
post embryonic development GO:0009791 2 0.129
response to metal ion GO:0010038 84 0.123
acylglycerol metabolic process GO:0006639 27 0.109
cellular modified amino acid metabolic process GO:0006575 64 0.105
protein tetramerization GO:0051262 47 0.103
small molecule biosynthetic process GO:0044283 157 0.097
lipid biosynthetic process GO:0008610 177 0.095
triglyceride metabolic process GO:0006641 23 0.095
cellular ketone metabolic process GO:0042180 80 0.081
reactive oxygen species metabolic process GO:0072593 75 0.080
sulfur compound metabolic process GO:0006790 101 0.075
fatty acid beta oxidation GO:0006635 22 0.070
cellular hormone metabolic process GO:0034754 41 0.070
protein oligomerization GO:0051259 173 0.069
neutral lipid metabolic process GO:0006638 27 0.068
terpenoid metabolic process GO:0006721 27 0.066
negative regulation of cell death GO:0060548 345 0.066
response to inorganic substance GO:0010035 127 0.065
fatty acid metabolic process GO:0006631 115 0.064
response to oxidative stress GO:0006979 121 0.062
response to oxygen containing compound GO:1901700 369 0.061
positive regulation of transport GO:0051050 336 0.061
glycerolipid metabolic process GO:0046486 107 0.059
fatty acid catabolic process GO:0009062 29 0.058
hemoglobin metabolic process GO:0020027 3 0.054
regulation of cellular ketone metabolic process GO:0010565 50 0.053
response to abiotic stimulus GO:0009628 336 0.052
response to reactive oxygen species GO:0000302 61 0.049
lipid catabolic process GO:0016042 84 0.048
response to radiation GO:0009314 151 0.048
protein homotetramerization GO:0051289 28 0.048
amine metabolic process GO:0009308 44 0.047
cellular response to oxygen containing compound GO:1901701 276 0.046
response to organic cyclic compound GO:0014070 204 0.045
female gamete generation GO:0007292 2 0.045
organic acid biosynthetic process GO:0016053 97 0.044
endosomal transport GO:0016197 129 0.044
lipid localization GO:0010876 106 0.043
Worm
phospholipid transport GO:0015914 23 0.042
response to biotic stimulus GO:0009607 276 0.041
Worm
secretion by cell GO:0032940 226 0.041
cellular response to oxidative stress GO:0034599 85 0.041
system process GO:0003008 349 0.040
purine nucleoside triphosphate metabolic process GO:0009144 412 0.040
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.039
response to external biotic stimulus GO:0043207 261 0.037
Worm
lipid transport GO:0006869 90 0.037
energy derivation by oxidation of organic compounds GO:0015980 43 0.037
single organism membrane organization GO:0044802 268 0.036
response to other organism GO:0051707 261 0.036
Worm
primary alcohol metabolic process GO:0034308 17 0.036
hydrogen peroxide metabolic process GO:0042743 20 0.035
negative regulation of apoptotic process GO:0043066 316 0.035
cellular amine metabolic process GO:0044106 41 0.035
negative regulation of programmed cell death GO:0043069 321 0.035
organic hydroxy compound biosynthetic process GO:1901617 71 0.035
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.034
anion transport GO:0006820 161 0.034
fatty acid oxidation GO:0019395 31 0.034
cellular lipid catabolic process GO:0044242 65 0.033
vesicle mediated transport GO:0016192 371 0.033
carboxylic acid biosynthetic process GO:0046394 97 0.033
single organism cellular localization GO:1902580 332 0.033
cellular response to hydrogen peroxide GO:0070301 37 0.032
generation of precursor metabolites and energy GO:0006091 68 0.032
diterpenoid metabolic process GO:0016101 20 0.032
immune response GO:0006955 307 0.032
Worm
purine ribonucleoside metabolic process GO:0046128 437 0.031
fatty acid beta oxidation using acyl coa dehydrogenase GO:0033539 3 0.031
organophosphate biosynthetic process GO:0090407 163 0.031
positive regulation of catabolic process GO:0009896 310 0.031
glycosyl compound catabolic process GO:1901658 413 0.031
response to uv GO:0009411 73 0.031
response to light stimulus GO:0009416 87 0.030
glutathione metabolic process GO:0006749 20 0.030
positive regulation of phosphatidylinositol 3 kinase signaling GO:0014068 28 0.030
response to lipid GO:0033993 206 0.030
organic anion transport GO:0015711 103 0.029
maintenance of location GO:0051235 112 0.029
Worm
ribonucleoside catabolic process GO:0042454 406 0.029
nervous system development GO:0007399 293 0.029
defense response GO:0006952 315 0.029
Worm
innate immune response GO:0045087 178 0.029
Worm
response to hormone GO:0009725 175 0.028
cellular amide metabolic process GO:0043603 69 0.028
hydrogen peroxide catabolic process GO:0042744 13 0.028
memory GO:0007613 3 0.028
positive regulation of nf kappab transcription factor activity GO:0051092 81 0.028
inositol lipid mediated signaling GO:0048017 55 0.028
sterol transport GO:0015918 39 0.028
regulation of cellular amine metabolic process GO:0033238 11 0.028
regulation of cellular amino acid metabolic process GO:0006521 6 0.027
cell part morphogenesis GO:0032990 137 0.027
nucleoside catabolic process GO:0009164 408 0.026
response to steroid hormone GO:0048545 80 0.026
associative learning GO:0008306 1 0.026
ribonucleotide catabolic process GO:0009261 405 0.026
regulation of hormone levels GO:0010817 125 0.026
peripheral nervous system development GO:0007422 2 0.026
cellular respiration GO:0045333 21 0.026
cellular component morphogenesis GO:0032989 314 0.026
ossification GO:0001503 121 0.026
cellular response to reactive oxygen species GO:0034614 50 0.025
mitotic cell cycle GO:0000278 326 0.025
purine ribonucleotide catabolic process GO:0009154 404 0.025
cell morphogenesis GO:0000902 296 0.025
purine ribonucleoside catabolic process GO:0046130 398 0.025
ribonucleoside triphosphate metabolic process GO:0009199 412 0.025
organophosphate ester transport GO:0015748 32 0.025
neuromuscular junction development GO:0007528 3 0.025
regulation of cell cycle GO:0051726 393 0.025
cell projection organization GO:0030030 252 0.024
oocyte differentiation GO:0009994 2 0.024
tricarboxylic acid metabolic process GO:0072350 4 0.024
intracellular protein transport GO:0006886 270 0.024
organophosphate catabolic process GO:0046434 430 0.024
sterol metabolic process GO:0016125 28 0.024
membrane organization GO:0061024 292 0.024
apoptotic signaling pathway GO:0097190 268 0.024
regulation of phosphatidylinositol 3 kinase signaling GO:0014066 35 0.024
positive regulation of cellular amine metabolic process GO:0033240 7 0.023
negative regulation of catalytic activity GO:0043086 335 0.023
steroid biosynthetic process GO:0006694 46 0.023
segmentation GO:0035282 4 0.023
plasma membrane organization GO:0007009 115 0.023
chemotaxis GO:0006935 157 0.023
organic hydroxy compound transport GO:0015850 63 0.023
endocytosis GO:0006897 159 0.023
alcohol biosynthetic process GO:0046165 52 0.023
oogenesis GO:0048477 2 0.022
negative regulation of protein metabolic process GO:0051248 391 0.022
cytoplasmic transport GO:0016482 379 0.022
locomotory behavior GO:0007626 1 0.022
purine nucleotide catabolic process GO:0006195 405 0.022
negative regulation of cellular protein metabolic process GO:0032269 353 0.022
purine containing compound catabolic process GO:0072523 411 0.022
cholesterol transport GO:0030301 39 0.022
blastoderm segmentation GO:0007350 2 0.022
response to transition metal nanoparticle GO:1990267 29 0.022
cofactor metabolic process GO:0051186 87 0.021
ribonucleoside triphosphate catabolic process GO:0009203 391 0.021
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.021
regulation of intracellular transport GO:0032386 195 0.021
aging GO:0007568 66 0.021
Worm
endomembrane system organization GO:0010256 196 0.021
cell development GO:0048468 328 0.021
Mouse
neurological system process GO:0050877 163 0.021
purine nucleoside triphosphate catabolic process GO:0009146 392 0.021
nucleotide catabolic process GO:0009166 408 0.021
positive regulation of hydrolase activity GO:0051345 331 0.021
regulation of secretion GO:0051046 194 0.020
neuron development GO:0048666 113 0.020
protein localization to plasma membrane GO:0072659 93 0.020
protein maturation GO:0051604 233 0.020
taxis GO:0042330 157 0.020
regulation of lipid metabolic process GO:0019216 96 0.020
purine nucleoside catabolic process GO:0006152 398 0.020
nucleoside triphosphate catabolic process GO:0009143 394 0.020
oocyte development GO:0048599 1 0.020
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.020
positive regulation of lipid biosynthetic process GO:0046889 22 0.020
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.019
organonitrogen compound biosynthetic process GO:1901566 200 0.019
protein processing GO:0016485 226 0.019
cation homeostasis GO:0055080 189 0.019
nucleoside monophosphate metabolic process GO:0009123 191 0.019
secretion GO:0046903 254 0.019
response to hydrogen peroxide GO:0042542 40 0.019
regulation of transferase activity GO:0051338 355 0.018
single organism reproductive process GO:0044702 98 0.018
Mouse
neurogenesis GO:0022008 169 0.018
dicarboxylic acid metabolic process GO:0043648 29 0.018
cellular response to endogenous stimulus GO:0071495 336 0.018
nucleoside triphosphate metabolic process GO:0009141 422 0.018
cell projection morphogenesis GO:0048858 129 0.018
regulation of proteolysis GO:0030162 293 0.018
negative regulation of cell cycle GO:0045786 193 0.018
negative regulation of transport GO:0051051 176 0.018
single organism carbohydrate metabolic process GO:0044723 193 0.018
coenzyme metabolic process GO:0006732 65 0.018
ribonucleoside monophosphate metabolic process GO:0009161 187 0.018
transmembrane transport GO:0055085 399 0.018
response to bacterium GO:0009617 144 0.018
Worm
regulation of kinase activity GO:0043549 314 0.017
guanosine containing compound metabolic process GO:1901068 244 0.017
carbohydrate metabolic process GO:0005975 207 0.017
cholesterol metabolic process GO:0008203 28 0.017
cell morphogenesis involved in differentiation GO:0000904 144 0.017
positive regulation of nucleotide metabolic process GO:0045981 230 0.017
actin filament based process GO:0030029 224 0.017
negative regulation of cellular component organization GO:0051129 235 0.017
positive regulation of cellular catabolic process GO:0031331 284 0.017
cellular macromolecule catabolic process GO:0044265 380 0.017
mitotic cell cycle process GO:1903047 286 0.017
engulfment of apoptotic cell GO:0043652 2 0.017
cardiac muscle cell contraction GO:0086003 4 0.017
negative regulation of nf kappab transcription factor activity GO:0032088 51 0.017
ras protein signal transduction GO:0007265 73 0.017
response to copper ion GO:0046688 8 0.017
rho protein signal transduction GO:0007266 26 0.017
regeneration GO:0031099 4 0.016
microtubule based process GO:0007017 210 0.016
protein localization to organelle GO:0033365 280 0.016
peptide metabolic process GO:0006518 51 0.016
protein localization to membrane GO:0072657 160 0.016
mitochondrion organization GO:0007005 156 0.016
regulation of endopeptidase activity GO:0052548 170 0.016
neuron differentiation GO:0030182 138 0.016
positive regulation of cellular component organization GO:0051130 376 0.016
negative regulation of cellular amine metabolic process GO:0033239 3 0.016
cell activation GO:0001775 213 0.016
tripartite regional subdivision GO:0007351 2 0.016
phosphatidylinositol 3 kinase signaling GO:0014065 48 0.016
regulation of cellular component biogenesis GO:0044087 281 0.016
cellular response to dna damage stimulus GO:0006974 379 0.016
positive regulation of lipid metabolic process GO:0045834 50 0.015
nucleoside phosphate catabolic process GO:1901292 412 0.015
anterior posterior axis specification embryo GO:0008595 2 0.015
negative regulation of phosphorus metabolic process GO:0010563 267 0.015
c21 steroid hormone biosynthetic process GO:0006700 11 0.015
reproductive process GO:0022414 106 0.015
Mouse
cellular homeostasis GO:0019725 196 0.015
regulation of cell cycle process GO:0010564 266 0.015
regulation of protein localization GO:0032880 296 0.015
regulation of steroid metabolic process GO:0019218 32 0.015
generation of neurons GO:0048699 152 0.015
regulation of protein maturation GO:1903317 150 0.015
anterior posterior axis specification GO:0009948 2 0.015
polyol metabolic process GO:0019751 32 0.015
defense response to other organism GO:0098542 129 0.015
Worm
very long chain fatty acid metabolic process GO:0000038 19 0.015
Mouse
regulation of cell differentiation GO:0045595 393 0.015
regulation of protein kinase activity GO:0045859 289 0.014
adult locomotory behavior GO:0008344 1 0.014
regulation of cellular response to stress GO:0080135 244 0.014
nucleoside monophosphate catabolic process GO:0009125 159 0.014
purine nucleoside monophosphate metabolic process GO:0009126 186 0.014
chemical homeostasis GO:0048878 306 0.014
cellular macromolecular complex assembly GO:0034622 324 0.014
rna processing GO:0006396 255 0.014
2 oxoglutarate metabolic process GO:0006103 4 0.014
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.014
regulation of secretion by cell GO:1903530 177 0.014
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.014
meiosis i GO:0007127 4 0.013
monocarboxylic acid biosynthetic process GO:0072330 67 0.013
negative regulation of hydrolase activity GO:0051346 182 0.013
positive regulation of nucleotide catabolic process GO:0030813 185 0.013
negative regulation of protein processing GO:0010955 142 0.013
mitotic cell cycle phase transition GO:0044772 162 0.013
cell cell signaling GO:0007267 155 0.013
protein catabolic process GO:0030163 325 0.013
dna repair GO:0006281 198 0.013
c21 steroid hormone metabolic process GO:0008207 17 0.013
spermatid development GO:0007286 4 0.013
small gtpase mediated signal transduction GO:0007264 78 0.013
negative regulation of protein maturation GO:1903318 142 0.013
regulation of cellular component movement GO:0051270 334 0.013
central nervous system development GO:0007417 123 0.013
negative regulation of cell cycle process GO:0010948 121 0.013
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.013
regulation of establishment of protein localization GO:0070201 242 0.013
response to nitrogen compound GO:1901698 184 0.013
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.013
epithelium development GO:0060429 227 0.013
Mouse
regulation of cytokine production GO:0001817 232 0.013
negative regulation of intracellular signal transduction GO:1902532 183 0.013
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.012
negative regulation of phosphate metabolic process GO:0045936 267 0.012
organelle fission GO:0048285 149 0.012
guanosine containing compound catabolic process GO:1901069 239 0.012
golgi vesicle transport GO:0048193 80 0.012
isoprenoid metabolic process GO:0006720 39 0.012
regulation of purine nucleotide metabolic process GO:1900542 264 0.012
embryo development GO:0009790 123 0.012
alpha amino acid metabolic process GO:1901605 72 0.012
positive regulation of immune system process GO:0002684 283 0.012
regulation of protein transport GO:0051223 213 0.012
spermatid differentiation GO:0048515 4 0.012
cellular response to organic cyclic compound GO:0071407 127 0.012
positive regulation of apoptotic process GO:0043065 246 0.012
purine nucleoside monophosphate catabolic process GO:0009128 158 0.012
cellular metal ion homeostasis GO:0006875 146 0.012
cellular aldehyde metabolic process GO:0006081 20 0.012
immune effector process GO:0002252 159 0.012
protein targeting GO:0006605 187 0.012
unsaturated fatty acid metabolic process GO:0033559 37 0.012
positive regulation of organelle organization GO:0010638 195 0.012
regulation of vesicle mediated transport GO:0060627 130 0.011
regulation of protein processing GO:0070613 150 0.011
neuron projection development GO:0031175 106 0.011
positive regulation of programmed cell death GO:0043068 249 0.011
long chain fatty acid metabolic process GO:0001676 30 0.011
ion transmembrane transport GO:0034220 338 0.011
negative regulation of organelle organization GO:0010639 126 0.011
regulation of purine nucleotide catabolic process GO:0033121 205 0.011
circulatory system development GO:0072359 262 0.011
cellular protein catabolic process GO:0044257 261 0.011
compound eye development GO:0048749 1 0.011
negative regulation of proteolysis GO:0045861 132 0.011
regulation of cysteine type endopeptidase activity GO:2000116 127 0.011
cell cycle phase transition GO:0044770 173 0.011
inorganic ion transmembrane transport GO:0098660 231 0.011
ribonucleoside monophosphate catabolic process GO:0009158 158 0.011
organelle fusion GO:0048284 36 0.011
positive regulation of secretion GO:0051047 116 0.011
biological adhesion GO:0022610 331 0.011
positive regulation of developmental process GO:0051094 314 0.011
regulation of peptidase activity GO:0052547 180 0.011
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.011
negative regulation of protein modification process GO:0031400 200 0.011
cellular carbohydrate metabolic process GO:0044262 84 0.011
positive regulation of cell differentiation GO:0045597 211 0.011
reactive oxygen species biosynthetic process GO:1903409 4 0.011
negative regulation of multicellular organismal process GO:0051241 317 0.011
regulation of synaptic plasticity GO:0048167 3 0.011
monosaccharide metabolic process GO:0005996 74 0.011
cellular chemical homeostasis GO:0055082 180 0.011
hormone metabolic process GO:0042445 61 0.010
long term memory GO:0007616 2 0.010
regulation of nucleotide catabolic process GO:0030811 205 0.010
anterograde axon cargo transport GO:0008089 1 0.010
atp catabolic process GO:0006200 157 0.010
enzyme linked receptor protein signaling pathway GO:0007167 303 0.010
regulation of nucleotide metabolic process GO:0006140 269 0.010
positive regulation of intracellular transport GO:0032388 104 0.010
reactive nitrogen species metabolic process GO:2001057 3 0.010
establishment of protein localization to organelle GO:0072594 172 0.010
hematopoietic or lymphoid organ development GO:0048534 186 0.010
limbic system development GO:0021761 3 0.010
eye photoreceptor cell differentiation GO:0001754 2 0.010
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.010
regulation of dna metabolic process GO:0051052 153 0.010

HSD17B4 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.874
inherited metabolic disorder DOID:655 242 0.874
disease of cellular proliferation DOID:14566 174 0.094
glycogen storage disease DOID:2747 10 0.075
carbohydrate metabolic disorder DOID:2978 55 0.075
glycogen metabolism disorder DOID:0050728 10 0.075
amino acid metabolic disorder DOID:9252 50 0.067
cancer DOID:162 167 0.037
central nervous system disease DOID:331 186 0.019
nervous system disease DOID:863 431 0.019
immune system disease DOID:2914 155 0.013
hematopoietic system disease DOID:74 100 0.013
sensory system disease DOID:0050155 203 0.012
cardiovascular system disease DOID:1287 106 0.010
eye and adnexa disease DOID:1492 150 0.010
perrault syndrome DOID:0050857 4 0.001